OHARA NAOKO 大原直子

… Alternative Names

OHHARA Naoko 大原直子

OHARA Naoko 大原直子

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Researcher Number	80301365
Other IDs
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 岡山大学, 医歯薬学域, 准教授 2017 – 2020: 岡山大学, 大学病院, 講師 2016: 岡山大学, 医歯薬学総合研究科, 助教 2012 – 2016: 岡山大学, 医歯(薬)学総合研究科, 助教 2013: 岡山大学, 大学院医歯薬学総合研究科, 助教 … More 2010 – 2012: 岡山大学, 大学院・医歯薬学総合研究科, 助教 2009 – 2010: Nihon University, 歯学部, 助教 2005 – 2006: 長崎大学, 大学院医歯薬学総合研究科, 助手 2002 – 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助手 2003: Nagasaki University, GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, Lecturer, 大学院・医歯薬学総合研究所, 助手 1998 – 2001: 長崎大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Conservative dentistry / Conservative dentistry / Basic Section 57080:Social dentistry-related / Basic Section 57030:Conservative dentistry-related / Prosthetic dentistry Except Principal Investigator Conservative dentistry / Pathobiological dentistry/Dental radiology / Basic Section 57020:Oral pathobiological science-related / Bacteriology (including mycology) / Conservative dentistry / Morphological basic dentistry / Prosthetic dentistry
Keywords	Principal Investigator 根面う蝕 / う蝕 / う蝕細菌 / う蝕誘発モデル / 石灰化 / アルカリフォスファテース / 酵素反応 / 根面齲蝕 / 放線菌 / プラークコントロール … More / アルギニンデイミナーゼシステム / アクチノマイセス属細菌 / う蝕管理法 / アクチノマイセス / 化合物 / 象牙質接着 / レジンセメント / 16SrRNA / 口腔細菌 / 感染象牙質 / Actinomyces / PCR / 根尖性歯周炎 / 骨吸収 / 感染 / CD137 / 破骨細胞 / 細菌 / アルカリファスファテース / 遺伝子組換え / GFP / 歯髄細胞 … More Except Principal Investigator キトサン / 病原因子 / ジンジパイン / 歯周病 / シグナル伝達 / 歯周病細菌 / 歯周病原細菌 / 細菌 / osteocalcin / ALP / リアルタイムPCR / 間葉系幹細胞 / タンパク質分解酵素 / 炎症 / 感染症 / プロスタグランジンE2 (PGE2) / カルシウムシグナリング / 細胞内シグナル伝達 / プロスタグランジンE2 / Porphyromonas gingivalis / シクロオキシゲナーゼ-2 / アラキドン酸代謝 / 細胞内カルシウム / 歯周炎 / カルシウム / porphyromonas gingivalis / Porphyromonas gingipain / 増殖速度 / BCG / 結核 / 葉酸代謝 / 増殖 / マイコバクテリウム / PI3K/Akt経路 / PI3K/Akt / real-time PCR / BMP- / cDNA microarray / bone marrow-derived progenitor cells / hard tissue regeneration / chitosan / 培養骨芽細胞 / BMP-2 / cDNAマイクロアレイ / 硬組織再生 / ELECTROPORATION / CELL DIFFERENTIATION・PROLIFERATION / INTRODUCTION OF GENE / SIGNAL TRANSDUCTION / CELL ACTIVATION / CHITOSAN / 象牙質再生 / ジーンデリバリーシステム / エレクトロポレーション / 細胞分化・増殖 / 遺伝子導入 / 細胞賦活作用 / Alkaline phosnhatase / Osteoblasts / Microgravity / Chitosan / バイオマテリアル / 齲蝕治療 / 齲蝕予防 / 生物学的石灰化 / キトサンオリゴ糖 / 水溶性キトサン / アルカリフォスファターゼ / 骨芽細胞 / 微小重力 / 接着歯学 / 細菌学 / 歯科保存修復学 / 歯学 / gingivalis / 感染 / 嫌気性菌 / Porphyromonas / 細胞内寄生 / 冠橋義歯学 / クラウンブリッジ / 自己学習プログラム / 支台歯形成 / 遺伝子増幅 / 細胞性石灰化 / 細胞分化 / 間歯系幹細胞 Less

歯周病細菌主要病原因子ジンジパインの宿主直接作用と必須新奇オペロンの解明
- Principal Investigator
  
  大原直也
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Okayama University
細菌の酵素反応を基盤とした根面う蝕管理法の開発Principal Investigator
- Principal Investigator
  
  大原直子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Okayama University
Establishment of a method for caries management using alkali-producing Actinomyces bacteriaPrincipal Investigator
- Principal Investigator
  
  OHARA Naoko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Okayama University
Understanding the pathogenicity of periodontal disease onset and systemic disease exacerbation caused by periodontal bacteria
- Principal Investigator
  
  OHARA Naoya
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Okayama University
Analysis the virulence of Mycobacterium tuberculosis based of rapid-growing BCG
- Principal Investigator
  
  Ohara Naoya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Okayama University
Development of a novel root caries treatment by bacterial inactivation factorPrincipal Investigator
- Principal Investigator
  
  OHARA Naoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Okayama University
Molecular mechanisms of periodontal diseases and systematic diseases associated with periodontal diseases by periodontal pathogens
- Principal Investigator
  
  OHARA Naoya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Okayama University
Kinetic analysis of cariogenic bacteria on root dentin cariesPrincipal Investigator
- Principal Investigator
  
  OHARA NAOKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Okayama University
The application of bacterial biomineralization to sealed restoration
- Principal Investigator
  
  YOSHIYAMA MASAHIRO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Conservative dentistry
- Research Institution
  Okayama University
Study on the survival strategies for periodontal bacteria in host cells and their role in the pathogenesis of periodontal diseases
- Principal Investigator
  
  OHARA Naoya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Okayama University
Application of chemical compound to improve the bond strength of resin cementPrincipal Investigator
- Principal Investigator
  
  OHARA Naoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Okayama University
  Nihon University
Development of self-learning training program for tooth preparation and its practical effects
- Principal Investigator
  
  KAKEHASHI Yoshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Nihon University
歯科保存領域での効果的な細胞移植再生治療の新規開発に関する基礎的研究
- Principal Investigator
  
  HAYASHI Yoshihiko
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
根面う蝕原性細菌の検出・定量化と多様性解析の試みPrincipal Investigator
- Principal Investigator
  
  大原直子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
Creation and clinical application of the three-dimensional cultured cell transplantation for hard tissue regeneration
- Principal Investigator
  
  IKEDA Takeshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
DEVELOPMENT OF DENTINE REGENERATION THERAPY BY GENE DELIVARY SYSTEM USING NATURAL BIOACTIVE MATERIAL, CHITOSAN
- Principal Investigator
  
  HAYASHI Yoshihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
根尖性歯周炎に対する免疫分子をベースとした骨吸収抑制剤開発の試みPrincipal Investigator
- Principal Investigator
  
  大原直子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
APPLICATION OF NATURAL ORGANIC BIOACTIVE MATERIAL, CHITOSAN TO PREVENTION AND CURE FOR DENTAL CARIES
- Principal Investigator
  
  HAYASHI Yoshihiko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
アルカリフォスファテース遺伝子導入によるう蝕原性細菌の人為的石灰化法の開発Principal Investigator
- Principal Investigator
  
  大原直子
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
アルカリフォスファテース遺伝子導入による培養歯髄細胞の硬組織形成能Principal Investigator
- Principal Investigator
  
  大原直子
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University

[Journal Article] Roles of Porphyromonas gulae proteases in bacterial and host cell biology2021
- Author(s)
  Urmi AS, Inaba H, Nomura R, Yoshida S, Ohara N, Asai F, Nakano K, Matsumoto-Nakano M
- Journal Title
  
  Cellular Microbiology
  
  Volume: in press Issue: 8
- DOI
  10.1111/cmi.13312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09918, KAKENHI-PROJECT-17H04378, KAKENHI-PROJECT-20H03897, KAKENHI-PROJECT-21K17182
[Journal Article] Construction and Characterization of the PGN_0296 Mutant of Porphyromonas gingivalis2020
- Author(s)
  Abu Saleh Muhammad Shahriar, Shintaro Ono, Masaaki Nakayama, Naoko Ohara, Naoya Ohara
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 62 Issue: 4 Pages: 322-326
- DOI
  10.1016/j.job.2020.09.007
- NAID
  120007163671
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11668, KAKENHI-PROJECT-20K18475, KAKENHI-PROJECT-17H04378
[Journal Article] Construction and Characterization of a PGN_0297 Mutant of Porphyromonas gingivalis: Evidence of the Contribution of PGN_0297 to Gingipain Activity2019
- Author(s)
  Shintaro Ono, Masaaki Nakayama, Masato Tachibana, Abu Saleh Muhammad Shahriar, Wang Heling, Shogo Takashiba, and Naoya Ohara
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 73 Issue: 4 Pages: 315-323
- DOI
  10.18926/AMO/56933
- NAID
  120006713034
- URL
  https://ousar.lib.okayama-u.ac.jp/56933
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11668, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-17H04378
[Journal Article] Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Porphyromonas gingivalis Gingipains RgpA, RgpB, and Kgp2015
- Author(s)
  Nakayama M, Inoue T, Naito M, Nakayama K, Ohara N
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Issue: 8 Pages: 5190-5202
- DOI
  10.1074/jbc.m114.591610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592765, KAKENHI-PROJECT-26293401, KAKENHI-PROJECT-26861573
[Journal Article] Involvement of an Skp-Like Protein, PGN_0300, in the Type IX Secretion System of Porphyromonas gingivalis.2015
- Author(s)
  Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K, Takashiba S, Ohara N.
- Journal Title
  
  Infection and Immunity
  
  Volume: 84 Issue: 1 Pages: 230-40
- DOI
  10.1128/iai.01308-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20598, KAKENHI-PROJECT-26861573, KAKENHI-PROJECT-25462866, KAKENHI-PROJECT-25293375, KAKENHI-PROJECT-26293401
[Journal Article] Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis ATCC 332772015
- Author(s)
  Inoue T, Nakayama M, Taguchi Y, Kano K, Ono M, Shimizu Y, Kuroda T, Ohara N.
- Journal Title
  
  New Microbiol
  
  Volume: 38 Pages: 97-103
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293401
[Journal Article] Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis2015
- Author(s)
  Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T, Hasegawa H
- Journal Title
  
  BMC Oral Health
  
  Volume: 15 Issue: 1 Pages: 4-4
- DOI
  10.1186/1472-6831-15-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592778, KAKENHI-PROJECT-26463171, KAKENHI-PROJECT-26861573, KAKENHI-PROJECT-26293401
[Journal Article] Development of a novel plasmid vector pTIO-1 adapted for electrotransformation of Porphyromonas gingivalis.2014
- Author(s)
  Tagawa J, Inoue T, Naito M, Sato K, Kuwahara T, Nakayama M, Nakayama K, Yamashiro T, Ohara N.
- Journal Title
  
  J Microbiol Methods
  
  Volume: 105 Pages: 174-179
- DOI
  10.1016/j.mimet.2014.07.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293401, KAKENHI-PROJECT-26460530, KAKENHI-PROJECT-26861573
[Journal Article] Chitosan monomer accelerates alkaline phosphatase activity on human osteoblastic cells under hypofunctional conditions2007
- Author(s)
  Yamada S, Ganno T, Ohara N, Hayashi Y
- Journal Title
  
  Journal of Biomedical materials Research A (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer2007
- Author(s)
  Ganno T, Yamada S, Ohara N, Matsunaga T, Yanagiguchi K, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research In press
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Chewing chitosan-containing gum effectively inhibits the growth of cariogenic bacteria2007
- Author(s)
  Hayashi Y, Ohara N, Ganno T, Yamaguchi K, Ishizaki H, Nakamura T, Sato M
- Journal Title
  
  Archives of Oral Biology 52・3
  
  Pages: 290-294
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer2007
- Author(s)
  Ganno T, Yamada S, Ohara N, Matsunaga T, Yanagiguchi K, Ikeda T, Ishizaki H, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research A 82
  
  Pages: 188-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659600
[Journal Article] Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer2007
- Author(s)
  Ganno T, Yamada S, Ohara N, Matsunaga T, Yanagiguchi K, Ikeda T, Ishizaki H, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research A (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Chewing chitosan-containing gum effectively inhibits the growth of cariogenic bacteria2007
- Author(s)
  Hayashi Y, Ohara N, Ganno T, Yamaguchi K, Ishizaki H, Nakamura T, Sato M
- Journal Title
  
  Archives of Oral Biology 52(3)
  
  Pages: 290-294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Chitosan monomer accelerates alkaline phosphatase activity on human osteoblastic cells under hypofunctional conditions2007
- Author(s)
  Yamada S, Ganno T, Ohara N, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research (in press)
- Data Source
  KAKENHI-PROJECT-17659600
[Journal Article] Chitosan monomer accelerates alkaline phosphatase activity on human osteoblastic cells under hypofunctional conditions2007
- Author(s)
  Yamada S, Ganno T, Ohara N, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research A 83
  
  Pages: 290-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659600
[Journal Article] Chitosan monomer accelerates alkaline phosphatase activity on human osteoblastic cells under hypofunctional conditions2007
- Author(s)
  Yamada S, Ganno T, Ohara N, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research A (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer2007
- Author(s)
  Ganno T, Yamadia S, Ohara N, Matsunaga T, Yanagiguchi K, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research (in press)
- Data Source
  KAKENHI-PROJECT-17659600
[Journal Article] Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer2007
- Author(s)
  Tomoko Ganno, Shizuka Yamada, Naoko Ohara, Tsunenori Matsunaga, Kajiro Yanagiguchi, Takeshi Ikeda, Hidetaka Ishizaki, Yoshihiko Hayashi
- Journal Title
  
  Jornal of Biomedical Materials Reserch (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591996
[Journal Article] Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer2007
- Author(s)
  Ganno T, Yamada S, Ohara N, Matsunaga T, Yanagiguchi K, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical materials Research A (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Chitosan monomer accelerates alkaline phosphatase activity on human osteoblastic cells under hypofunctional conditions2007
- Author(s)
  Shizuka Yamada, Tomoko Ganno, Naoko Ohara, Yoshihiko Hayashi
- Journal Title
  
  Jornal of Biomedical Materials Reserch (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591996
[Journal Article] Chitosan monomer promotes tissue regeneration on dental pulp wounds2006
- Author(s)
  Matsunaga T, Yanagiguchi K, Yamada S, Ohara N, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research 76A(4)
  
  Pages: 711-720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Chitosan monomer promotes tissue regeneration on dental pulp wounds2006
- Author(s)
  Matsunaga T, Yanagiguchi K, Yamada S, Ohara N, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research 76A(4)
  
  Pages: 711-720
- Data Source
  KAKENHI-PROJECT-17659600
[Journal Article] Chitosan monomer promotes tissue regeneration on dental pulp wounds2006
- Author(s)
  Matsunaga T, Yanagiguchi K, Yamada S, Ohara N, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical materials Research A 76・4
  
  Pages: 711-720
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Chitosan monomer promotes tissue regeneration on dental pulp wounds.2006
- Author(s)
  T.Matsunaga, K.Yanagiguchi, S.Yamada, N.Ohara, T Ikeda, Y.Hayashi
- Journal Title
  
  Jornal of Biomedical Materials Reserch 76A
  
  Pages: 711-720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591996
[Journal Article] Chitosan monomer promotes regeneration on dental pulp wounds2006
- Author(s)
  Matsunaga T, Yanagiguchi, Yamada S, Ohara N, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials research 76・4
  
  Pages: 711-720
- Data Source
  KAKENHI-PROJECT-17659600
[Journal Article] Chitosan monomer promotes tissue regeneration on dental pulp wounds2006
- Author(s)
  Matsunaga T, Yanagiguchi K, Yamada S, Ohara N, Ikeda T, Hayashi Y
- Journal Title
  
  Journal of Biomedical Materials Research 76・4
  
  Pages: 711-720
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Immunohistochemical and electron microscopic study of the biodegradation processes of chitin and chitosan implanted in rat alveolar bone2005
- Author(s)
  Ikeda T, Yanagiguchi K, Matsunaga T, Yamada S, Ohara N, Ganno T, Hayashi Y
- Journal Title
  
  Oral Medicine ＆ Pathology 10・4
  
  Pages: 131-138
- NAID
  130004509478
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Immunohistochemical and electron microscopic study of the biodegradation processes of chitin and chitosan implanted in rat alveolar bone.2005
- Author(s)
  T.Ikeda, K.Yanagiguchi, T.Matsunaga, S.Yamada, N Ohara, T.Ganno, Y.Hayashi
- Journal Title
  
  Oral Medicine ＆ Pathology 10(4)
  
  Pages: 131-138
- NAID
  130004509478
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591996
[Journal Article] Immunohistochemical and electron microscopic study of the biodegradation processes of chitin and chitosan implanted in rat alveolar bone2005
- Author(s)
  Ikeda T, Yanagiguchi K, Matsunaga T, Yamada S, Ohara N, Ganno T, Hayashi Y
- Journal Title
  
  Oral Medicine ＆ Pathology 10(4)
  
  Pages: 131-138
- NAID
  130004509478
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Early gene expression analyzed by cDNA microarray and RT-PCR in osteoblasts cultured with water-soluble and low molecular chitooligosaccharide2004
- Author(s)
  N.Ohara, Y.Hayashi, S.Yamada, S-K.Kim, T.Matsunaga, K.Yanagoguchi, T.Ikeda
- Journal Title
  
  Biomaterials 25・10
  
  Pages: 1749-1754
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Early gene expression analyzed by cDNA microarray and RT-PCR in osteoblasts cultured with water-soluble and low molecular chitooligosaccharide2004
- Author(s)
  Ohara N, Hayashi Y, Yamada S, Kim S-K, Matsunaga T, Yanagiguchi K, Ikeda T
- Journal Title
  
  Biomaterials 25・10
  
  Pages: 1749-1754
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Journal Article] Early gene expression analyzed by cDNA microarray and RT-PCR in osteoblasts cultured with water-soluble and low molecular chitooligosaccharide2004
- Author(s)
  Ohara N, Hayashi Y, Yamada S, Kim S-K, Matsunaga T, Yanagiguchi K, Ikeda T
- Journal Title
  
  Biomaterials 25(10)
  
  Pages: 1749-1754
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390547
[Patent] 特許2007
- Inventor(s)
  林善彦, 大原直子
- Industrial Property Rights Holder
  長崎大学
- Industrial Property Number
  2007-126868
- Filing Date
  2007-05-11
- Data Source
  KAKENHI-PROJECT-17659600
[Presentation] P. gingivalisジンジパインによる COX-2 発現における細胞外カルシウム流入の重要性2021
- Author(s)
  中山真彰，内藤真理子，中山浩次，大原直也
- Organizer
  第94回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] P. gingivalis ジンジパイン誘導性COX-2発現における細胞外カルシウム流入の関与2020
- Author(s)
  中山真彰, 内藤真理子, 中山浩次, 大原直也
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] P. gingivalisジンジパインによる COX-2 発現と細胞外カルシウム流入の分子機序2020
- Author(s)
  中山真彰，内藤真理子，中山浩次，大原直也
- Organizer
  第62回歯科基礎医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] Involvement of intracellular calcium on Porphyromonas gingivalis gingipains-induced COX-2 expression and PGE2 production2019
- Author(s)
  中山真彰, 内藤真理子, 中山浩次, 大原直也
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] 歯周病菌が産生するジンジパインによるCOX-2発現におけるカルシウムの役割2019
- Author(s)
  中山真彰, 内藤真理子, 中山浩次, 大原直也
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] P. gingivalis ジンジパインによるCOX-2発現誘導における細胞内Ca2+の関与2019
- Author(s)
  中山真彰, 内藤真理子, 中山浩次, 大原直也
- Organizer
  第72回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] Porphyromonas gingivalis PGN_0301 の機能解析の試み2018
- Author(s)
  王鶴齢，中山真彰，小野晋太郎，Abu Saleh Muhammad Shahriar、中山真彰、橘理人、大原直也
- Organizer
  第60回歯科基礎医学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] Investigation of genes involved in promoting the growth rate of BCG2018
- Author(s)
  竜門亜矢子，中山真彰，和田崇之，橘理人，阿戸学，中島千絵，鈴木定彦，小崎弘貴，大原直也
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] Inhibitory mechanism of JTY3476 expression by JTY3475 in BCG Tokyo2018
- Author(s)
  Masaaki Nakayama, Kaori Shirasaki, Masato Tachibana, Saburo Yamamoto, Takemasa Takii, Mayuko Okabe, Manabu Ato, Naoya Ohara
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] 歯周病細菌Porphyromonas gingivalisが産生するプロテアーゼによるPGE2産生の分子機序2018
- Author(s)
  大原直也
- Organizer
  第92回日本感染症学会学術講演会・第66回日本化学療法学会総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] Porphyromonas gingivalis gingipains によるMEK/ERK/AP-1およびIKK/NF-kBp65 の活性化を介したCOX-2 発現およびPGE2 産生の誘導機構2018
- Author(s)
  中山真彰、内藤真理子、橘理人、中山浩次、大原直也
- Organizer
  第60回歯科基礎医学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] Porphyromonas gingivalisジンジパインによるCOX-2発現誘導を介したPGE2 産生の分子解析2017
- Author(s)
  中山真彰，内藤真理子，橘理人，中山浩次，大原直也
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] BCGに存在する転写抑制因子Rv3405cの解析2017
- Author(s)
  白崎かおり, 中山真彰, 橘理人, 山本三郎, 瀧井猛将, 岡部真裕子, 阿戸学, 竜門亜矢子,小崎弘貴 , 上岡寛, 大原直也
- Organizer
  第70回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] 直接覆髄にBMP配合アルギン酸ゲルを用いた場合の硬組織反応2017
- Author(s)
  山路公造, 横山章人, 松崎久美子, 大原直子, 島田康史, 神農泰生, 高橋圭, 田畑泰彦, 吉山昌宏
- Organizer
  第15回日本再生歯科医学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] Porphyromonas gingivalisジンジパインによるCOX-2発現とPGE2産生の分子解析2017
- Author(s)
  中山真彰、内藤真理子、橘理人、中山浩次、大原直也
- Organizer
  第70回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] 口腔乾燥症モデル作製のための基礎的研究　吸水および乾燥による充填用材料の質量変化2017
- Author(s)
  澁谷和彦, 松崎久美子, 大原直子, 島田康史, 吉山昌宏
- Organizer
  147回日本歯科保存学会秋季学術大会
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] 充填用コンポジットレジンの経時的色調変化2017
- Author(s)
  小野瀬里奈，大原直子，松﨑久美子，澁谷和彦，横山章人，高橋圭，神農泰生，山路公造，島田康史，吉山昌宏
- Organizer
  第 38 回岡山歯学会学術集会
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] 歯周病におけるP. gingivalisジンジパインの重要性2017
- Author(s)
  中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] 充填用コンポジットレジンの色調に関する検討2017
- Author(s)
  大原直子，小野瀬里奈，松﨑久美子，澁谷和彦，横山章人，神農泰生，山路公造，吉山昌宏
- Organizer
  第146回日本歯科保存学会春季学術大会
- Place of Presentation
  リンクステーションホール青森（青森市）
- Year and Date
  2017-06-08
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] 口腔細菌と全身疾患の関連性2017
- Author(s)
  大原直也
- Organizer
  第87回日本感染症学会西日本地方会学術集会, 第60回日本感染症学会中日本地方会学術集会, 第65回日本化学療法学会西日本支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] BCG Tokyo 172-1に存在するサブポピュレーションI型とII型に関する新たな知見2017
- Author(s)
  田村庄平，白崎かおり，中山真彰，藤原永年，和田崇之，瀧井猛将，山本三郎，岡部真裕子，阿戸学，小崎弘貴，竜門亜矢子，大原直也
- Organizer
  第87回実験結核研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] Porphyromonas gingivalisジンジパインによるPGE2産生の分子機序2017
- Author(s)
  中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] BCG ThyA，ThyX変異株の解析2017
- Author(s)
  竜門亜矢子，中山真彰，橘理人，小崎弘貴，大原直也
- Organizer
  第59回歯科基礎医学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] Porphyromonas gingivalisジンジパインによるCOX-2発現とPGE2産生の分子機序2017
- Author(s)
  中山真彰、橘理人、内藤真理子、中山浩次、大原直也
- Organizer
  第59回歯科基礎医学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04378
[Presentation] チミジル酸合成酵素ThyXの過剰発現はBCGの増殖を促進する2016
- Author(s)
  竜門亜矢子、中山真彰、有村友紀、阿戸学、中島千絵、鈴木定彦、小崎弘貴、大原直也
- Organizer
  第69回日本細菌学会中国・四国支部総会
- Place of Presentation
  高松
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] Porphyromonas gingivalis　ECF シグマ因子変異株の性状解析2016
- Author(s)
  菊池有一郎，藤瀬和隆，柴山和子，国分栄仁，大原直也，中山浩次，石原和幸
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪市
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] P. gingivalis ジンジパインによるPI3K/Akt 経路撹乱の分子解析2016
- Author(s)
  中山真彰，内藤真理子，中山浩次，大原直也
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪市
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] P. gingivalisジンジパインの宿主細胞応答を介した病原性機能解析2016
- Author(s)
  中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第69回日本細菌学会中国・四国支部総会
- Place of Presentation
  高松
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] BCG thyXを用いた抗酸菌のPAS 耐性機序の解析2016
- Author(s)
  大原直也、阿戸学、鈴木定彦、小林和夫
- Organizer
  第91回日本結核病学会総会
- Place of Presentation
  金沢
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-16K15277
[Presentation] PI3K/Akt経路に対するP. gingivalis ジンジパインの役割2016
- Author(s)
  中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第58回歯科基礎医学会学術集会・総会
- Place of Presentation
  札幌
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] 咬耗面積・接触面積・咬合接触点による咬耗症例の解析2016
- Author(s)
  神農泰生，大原直子，松崎久美子，高橋圭，山路公造，吉山昌宏
- Organizer
  第145回日本歯科保存学会秋季学術大会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] Porphyromonas gingivalis　におけるsigma-54の機能2015
- Author(s)
  加野小奈美，井上哲圭，中山真彰，内藤真理子，田川淳平，中山浩次，上岡寛，大原直也
- Organizer
  第68回日本細菌学会総会中国・四国支部総会
- Place of Presentation
  岡山市
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] セルフアドヒーシブセメント中のMDP濃度が接着強さに及ぼす影響2015
- Author(s)
  大原直子, 田中久美子, 澁谷和彦, 横山章人, 竹内晶子, 山路公造, 西谷佳浩, 吉山昌宏
- Organizer
  第143回日本歯科保存学会学術大会
- Place of Presentation
  文京シビックホール（東京都文京区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K11113
[Presentation] Porphyromonas gingivalis ECFシグマ因子変異株の性状解析2015
- Author(s)
  菊池有一郎、柴山和子、国分栄二、大原直也、中山浩次、石原和幸
- Organizer
  第57回歯科基礎医学会学術大会・総会
- Place of Presentation
  新潟市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] Porphyromonas gingivalis　におけるsigma-54の機能2015
- Author(s)
  加野小奈美，井上哲圭，中山真彰，内藤真理子，田川淳平，中山浩次，上岡寛，大原直也
- Organizer
  第68回日本細菌学会総会中国・四国支部総会
- Place of Presentation
  岡山市
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] Porphyromonas gingivalis ジンジパインによるPI3K/Akt経路の抑制効果とその意義2015
- Author(s)
  中山真彰，内藤真理子，中山浩次，大原直也
- Organizer
  第57回歯科基礎医学会学術大会・総会
- Place of Presentation
  新潟市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] P. gingivalis ジンジパインによるPI3K/Akt 経路撹乱の分子解析2015
- Author(s)
  中山真彰，内藤真理子，中山浩次，大原直也
- Organizer
  第68回日本細菌学会総会中国・四国支部総会
- Place of Presentation
  岡山市
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] P. gingivalisジンジパインによるPI3K/Akt経路の抑制機序2013
- Author(s)
  中山真彰、井上哲圭、大原直也
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 細菌バイオミネラリゼーション誘導の試み2013
- Author(s)
  大原直子
- Organizer
  第139回日本歯科保存学会学術大会
- Place of Presentation
  秋田市
- Year and Date
  2013-10-17
- Data Source
  KAKENHI-PROJECT-24659847
[Presentation] P. gingivalisのECFシグマ因子PG1318変異株はミューテーター形質を示す2013
- Author(s)
  菊池有一郎，柴山和子，国分栄仁，大原直也，中山浩次，石原和幸
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 細菌バイオミネラリゼーション誘導の試み2013
- Author(s)
  大原直子、大原直也、田中久美子、澁谷和彦、横山章人、山路公造、西谷佳浩、吉山昌宏
- Organizer
  日本歯科保存学会　2013年度秋季学術大会
- Place of Presentation
  秋田市
- Data Source
  KAKENHI-PROJECT-24592866
[Presentation] 細菌バイオミネラリゼーション誘導の試み2013
- Author(s)
  大原直子, 大原直也, 田中久美子, 澁谷和彦, 横山章人, 山路公造, 西谷佳浩, 吉山昌宏
- Organizer
  第139回日本歯科保存学会
- Place of Presentation
  秋田県秋田市
- Data Source
  KAKENHI-PROJECT-24659847
[Presentation] P. gingivalisのECFシグマ因子PG1318 変異株はミューテーター形質を示す2013
- Author(s)
  菊池有一郎、柴山和子、国分栄二、大原直也、中山浩次、石原和幸
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] P. gingivalisジンジパインによるPI3K/Akt経路の抑制機序2013
- Author(s)
  中山真彰，井上哲圭，内藤真理子，中山浩次，大原直也
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] Porphyromonas gingivalisによる薬剤排出ポンプ様遺伝子破壊株の薬剤感受性2013
- Author(s)
  井上哲圭，中山真彰，大原直也
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] New aspect of signaling events in Porphyromonas gingivalispathogenesis2012
- Author(s)
  大原直也
- Organizer
  First International Conference on Porphyromonas gingivalisand related Bacterial Species
- Place of Presentation
  長崎市
- Year and Date
  2012-08-27
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] The significance of Akt dephosphorylation of Porphyromonas gingivalis2012
- Author(s)
  中山真彰，大原直也
- Organizer
  First International Conference on Porphyromonas gingivalis and related Bacterial Species
- Place of Presentation
  長崎大学良順会館（長崎市）
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 口腔連鎖球菌による歯根象牙質う蝕の誘発2012
- Author(s)
  大原直子、田中久美子、澁谷和彦、西谷佳浩、大原直也、吉山昌宏
- Organizer
  日本歯科保存学会　2012年度秋季学術大会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-24592866
[Presentation] 口腔連鎖細菌による歯根象牙質う蝕の誘発2012
- Author(s)
  大原直子
- Organizer
  第137回日本歯科保存学会学術大会
- Place of Presentation
  広島市
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-24659847
[Presentation] 歯肉上皮細胞におけるPorphyromonas gingivalis HbRによるIL-8産生機序2012
- Author(s)
  大原直也
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] Porphyromonas gingivali によるAkt/GSK3 beta pathwayの制御2012
- Author(s)
  中山真彰,井上哲圭,大原直也
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  郡山市
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 歯周病原細菌およびその病原性因子の全身疾患への影響2012
- Author(s)
  大原直也
- Organizer
  第60回日本化学療法学会学術集会
- Place of Presentation
  長崎市
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] Roles of the extracytoplasmic function sigma factors in Porphyromonas gingivalis2011
- Author(s)
  Ohara, N.
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology, International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] Roles of the extracytoplasmic function sigma factors in Porphyromonas gingivalis.2011
- Author(s)
  Kikuchi Y, Onozawa S, Kiso A, Miyashita M, Ueda O, Hirai K, Shibata Y, Ohara N, Nakayama K, Fujimura S
- Organizer
  XIII International Congress of Bacteriology and Applied MicrobiologyXIII International Congress of Bacteriology and Applied Microbiology, International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] Inhibition of RANK ligand- induced osteoclast differentiation by Porphyromonas gingivalis.2011
- Author(s)
  Nakayama M, Nakayama K, Kobayashi K, Ohara N
- Organizer
  XIII International Congress of Bacteriology and Applied MicrobiologyXIII International Congress of Bacteriology and Applied Microbiology, International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] MDPおよびフッ化ナトリウムの配合が試作レジンセメントの象牙質接着強さに及ぼす影響2011
- Author(s)
  渋谷和彦、大原直子、吉山昌宏, 他
- Organizer
  平成23年度日本歯科保存学会春季学術大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-21592477
[Presentation] マウスモデルから考える歯周病原細菌の病原性2011
- Author(s)
  大原直也
- Organizer
  第81回日本感染症学会西日本地方会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] MDPおよびフッ化ナトリウムの配合が試作レジンセメントの象牙質接着強さに及ぼす影響2011
- Author(s)
  澁谷和彦、大原直子、星加知宏、田中久美子、西谷佳浩、吉山昌宏
- Organizer
  第134回日本歯科保存学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-21592477
[Presentation] 歯肉上皮細胞の歯周病原細菌取り込みに対するキトサンの影響2011
- Author(s)
  大原直子
- Organizer
  第64回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] Porphyromonas gingivalis HbRによる歯肉上皮細胞のIL-8産生機序2011
- Author(s)
  大原直也
- Organizer
  第64回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] キトサンオリゴマーを配合した接着性レジンセメントの抗菌性の検討2010
- Author(s)
  大原直子、大原直也、田中久美子、渋谷和彦、伊澤俊次、山路公造、西谷佳浩、林善彦、吉山昌宏
- Organizer
  第8回日本再生歯科医学会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-21592477
[Presentation] 歯周病原細菌Porphyromonas gingivalisの新たな病原性に関する研究2010
- Author(s)
  大原直也
- Organizer
  第31回岡山歯学会総会・学術集会
- Place of Presentation
  岡山市(招待講演)
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 歯周病原細菌Porphyromonas gingivalisの新たな病原性に関する研究.特別講演2010
- Author(s)
  大原直也
- Organizer
  第31回岡山歯学会総会・学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] キトサンオリゴマーを配合した接着性レジンセメントの抗菌性の検討2010
- Author(s)
  大原直子
- Organizer
  第8回日本再生歯科医学会学術大会
- Place of Presentation
  愛知学院大学歯学部(名古屋市)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21592477
[Presentation] 歯周病原細菌およびその病原性因子の全身疾患への影響
- Author(s)
  大原直也
- Organizer
  第60回日本化学療法学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 口腔連鎖細菌による歯根象牙質う蝕の誘発
- Author(s)
  大原直子、田中久美子、渋谷和彦、西谷佳浩、大原直也、吉山昌宏
- Organizer
  第137回日本歯科保存学会学術大会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-24659847
[Presentation] Actinomyces属3菌種による歯根象牙質う蝕の誘発
- Author(s)
  大原直子、大原直也、田中久美子、山路公造、西谷佳浩、吉山昌宏
- Organizer
  日本歯科保存学会
- Place of Presentation
  滋賀県大津市
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24592866
[Presentation] Porphyromonas gingivalis ATCC33277株における細胞外プロテアーゼ活性に関わる新規遺伝子について
- Author(s)
  田口裕子、井上哲圭、佐藤啓子、雪竹英治、加野小奈美、中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡県　福岡市
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] Porphyromonas gingivalisによるAkt/GSK3beta pathwayの制御
- Author(s)
  中山真彰，井上哲圭，大原直也
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  奥羽大学（郡山市）
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 細菌感染による免疫応答が破骨細胞分化に与える影響
- Author(s)
  中山真彰、井上哲圭、中山浩次、大原直也
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡県　福岡市
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] Porphyromonas gingivalisの表層蛋白質の修飾と機能に関与する分子の解析
- Author(s)
  田口裕子、佐藤啓子、雪竹英治、井上哲圭、中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県　岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] 歯周病原細菌の感染による免疫応答と破骨細胞分化制御の相関性
- Author(s)
  中山真彰、井上哲圭、中山浩次、大原直也
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県　岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] Porphyromonas gingivalis ATCC 33277株rpoN低発現株の性状解析
- Author(s)
  加野小奈美、井上哲圭、田口裕子、田川淳平、中山真彰、内藤真理子、中山浩次、大原直也
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県　岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] 細菌感染によるTLR2を介した破骨細胞分化制御とその意義
- Author(s)
  中山真彰、井上哲圭、中山浩次、大原直也
- Organizer
  第67回日本細菌学会中国・四国支部総会
- Place of Presentation
  徳島県　徳島市
- Year and Date
  2014-10-26 – 2014-10-27
- Data Source
  KAKENHI-PROJECT-26293401
[Presentation] New aspect of signaling events in Porphyromonas gingivalis pathogenesis
- Author(s)
  大原直也
- Organizer
  First International Conference on Porphyromonas gingivalis and related Bacterial Species
- Place of Presentation
  長崎大学良順会館（長崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-22390342
[Presentation] 細菌感染による破骨細胞分化への自然免疫応答の重要性
- Author(s)
  中山真彰、井上哲圭、中山浩次、大原直也
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県　岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293401

1. OHARA Naoya (70223930)

# of Collaborated Projects: 10 results

# of Collaborated Products: 76 results
2. YOSHIYAMA Masahiro (10201071)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
3. NAKAYAMA Masaaki (10579105)

# of Collaborated Projects: 5 results

# of Collaborated Products: 48 results
4. YANAGIGUCHI Kajiro (50264255)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
5. HAYASHI Yoshihiko (20150477)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
6. 松崎久美子 (50550802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAKEHASHI Yoshiyuki (80160993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KAMIMOTO Atsushi (30386114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOISUMI Hiroyasu (20339229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NISHITANI Yoshihiro (60325123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. IKEDA Takeshi (90244079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 山田志津香 (00363458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 井上哲圭 (20223258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
14. 橘理人 (20636831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 横山章人 (90806069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大森一弘 (20549860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐藤啓子 (70410579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 武部克希 (61000104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TAGUCHI Yuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. KANO Konami

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
21. KOSAKI Hirotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. RYUMON Ayako

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
23. KONDO Yoshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. KOKUBU Eitoyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 稲葉裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 石原和幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 菊池有一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHARA NAOKO 大原 直子

OHHARA Naoko 大原 直子

OHARA Naoko 大原 直子

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細菌の酵素反応を基盤とした根面う蝕管理法の開発Principal Investigator

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Establishment of a method for caries management using alkali-producing Actinomyces bacteriaPrincipal Investigator

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Development of a novel root caries treatment by bacterial inactivation factorPrincipal Investigator

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Kinetic analysis of cariogenic bacteria on root dentin cariesPrincipal Investigator

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Application of chemical compound to improve the bond strength of resin cementPrincipal Investigator

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根面う蝕原性細菌の検出・定量化と多様性解析の試みPrincipal Investigator

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OHARA NAOKO 大原直子

OHHARA Naoko 大原直子

OHARA Naoko 大原直子