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KOHYAMA Kuniko  神山 邦子

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… Alternative Names

神山 邦子  コウヤマ クニコ

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Researcher Number 80301795
Other IDs
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Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主任研究員
2025: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主任研究員
Affiliation (based on the past Project Information) *help 2014: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 基盤技術研究職員
2012: (財)東京都医学総合研究所, その他部局等, 研究員
2011: 財団法人東京都医学総合研究所, 基盤技術研究センター, 基盤技術研究職員
2010: (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2009: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 … More
2008: (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2007: Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員
2005 – 2006: (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2004: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2003: (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2001 – 2002: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2001: Tokyo Metropolitan Inst. for Neurosci., 東京都神経科学総合研究所, 研究員
2000: (財)東京都医学研究機構, 東京都神経科学総合研究所・神経病理研究部門, 主事研究員
2000: Tokyo Metropolitan Inst. for Neurosci., 東京都神経科学総合研究所・神経病理研究部門, 研究員
1999: Tokyo Metropolitan Inst. for Neurosci., 東京都神経科学総合研究所, 主事研究員
1999: 財団法人 東京都医学研究機構, 東京都神経科学総合研究所, 主事研究員
1998: (財)東京都神経科学総合研究所, 神経病理研究部門, 主事研究員 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Neurology / Neurology
Except Principal Investigator
Neurology / Neurology / Nerve anatomy/Neuropathology
Keywords
Principal Investigator
C蛋白 / 拡張型心筋症 / 自己免疫性心筋炎 / DNAワクチン / 筋炎惹起抗原 / T細胞レセプター / 自己免疫性筋炎 / C-protein / T cell receptor / myositogenic antigen … More / polymositis / タウ / アミロイドβ / アルツハイマー病治療 / MMP / 遺伝子治療 / DNAワクチン療法 / 筋炎惹起性抗原 … More
Except Principal Investigator
DNAワクチン / アルツハイマー病 / Aベータ / Central nervous system / STAT / T細胞レセプター / 免疫性神経疾患 / DNA vaccine / therapy / Alzheimer's disease / 治療 / DNA avaccine / CDR3 spectratyping / T cell receptor / Autoimmune disease / CDR3領域スペクトラタイピング / In situ hybridization / Glia / Autoimmune encephalomyelitis / Cytokine / Competitive PCR / in situ RT-PCR / インサイチュウハイブリダイゼーション / グリア細胞 / 自己免疫性脳脊髄炎 / サイトカイン / 競合PCR / 中枢神経 / DNAワクチン療法 / Aβ Less
  • Research Projects

    (12 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (13 People)
  •  Generation of new DNA vaccine plasmid for the therapy of Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      KOHYAMA Kuniko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Development of a new and effective DNA vaccine for Alzheimer's disease

    • Principal Investigator
      OKURA Yosio
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      財団法人東京都医学総合研究所
      Tokyo Metropolitan Organization for Medical Research
  •  Analysis of Abeta reduction mechanisms by non-viral DNA vaccine therapy for Alzheimer's disesase

    • Principal Investigator
      OKURA Yosio
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  ラット拡張型心筋症モデルにおける蛋白分解酵素MMPの作用機序解析及び治療法の開発Principal Investigator

    • Principal Investigator
      神山 邦子
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Development of non-viral A beta DNA vaccines against Alzheimer's disease

    • Principal Investigator
      OKURA Yoshio
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  C蛋白で誘発した心筋炎・拡張型心筋症の発症機序の解明と特異免疫療法の開発Principal Investigator

    • Principal Investigator
      神山 邦子
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  アルツハイマー病モデルの治療に有効なAβ・DNAワクチンの創製

    • Principal Investigator
      松本 陽
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  組み換えC蛋白で誘発した実験的多発筋炎の発症機構の解明と特異免疫療法の開発Principal Investigator

    • Principal Investigator
      神山 邦子
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Analysis on pathogenesis of experimetnal autoimmune polymyositis and development of gene thrapyPrincipal Investigator

    • Principal Investigator
      KOHYAMA Kuniko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  免疫性神経疾患の予防・治療に有効な遺伝子ワクチンの創製

    • Principal Investigator
      MATSUMOTO Yoh
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Characterization of T cell receptor (TCR) of neurological autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines

    • Principal Investigator
      MATSUMOTO Yoh
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Neurology
    • Research Institution
      Tokyo metropolitan Institute for Neuroscience
      Tokyo Metropolitan Institute for Neuroscience
  •  Role of cytokines in the lesion repair in the central nervous system

    • Principal Investigator
      MATSUMOTO Yoh
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

All 2015 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Alzheimer’s disease and immunotherapy: what is wrong with clinical trials?2015

    • Author(s)
      Kohyama K, Matsumoto Y
    • Journal Title

      ImmunoTargets and Therapy

      Volume: 4 Pages: 27-27

    • DOI

      10.2147/itt.s49923

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591283
  • [Journal Article] Assessment of non-viral AβDNA vaccines on Aβreduction and safety in rhesus monkeys2010

    • Author(s)
      Tokita Y, Kaji K, Lu J, Okura Y, Kohyama K, Matsumoto Y
    • Journal Title

      J Alzheimer Dis

      Volume: 22 Pages: 1351-1361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591103
  • [Journal Article] Assessment of non-viral Aβ DNA vaccines on Aβ reduction and safety in rhesus monkeys2010

    • Author(s)
      Tokita Y, Kaji K, Lu J, Okura Y, Kohyama K, Matsumoto Y.
    • Journal Title

      J Alz Dis

      Volume: 22 Pages: 1351-1361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591103
  • [Journal Article] Matrix metalloproteinase(MMP)-9, but not MMP-2, is involved in the development and progression of C-protein-induced myocarditis and subsequent dilated cardiomyopathy2009

    • Author(s)
      Matsumoto, Y, Park, I., Kohyama, K.
    • Journal Title

      J Immunol 183

      Pages: 4773-4781

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591103
  • [Journal Article] Non-viral DNA vaccination augments microglial phagocytosis of Aβ deposits as a major Aβ clearance pathway in an Alzheimer disease model mice2008

    • Author(s)
      Okura, Y., Kohyama K., Park, I., Matsumoto, Y.
    • Journal Title

      J Neuropathol Exp Neurol 67

      Pages: 1063-1071

    • Data Source
      KAKENHI-PROJECT-19591023
  • [Journal Article] Non-viral DNA vaccination augments microglial phagocytosis of Ass deposits as a major Ass clearance pathway in an Alzheimer disease model mice2008

    • Author(s)
      Okura, Y., Kohyama K., Park, I., Matsumoto, Y.
    • Journal Title

      J Neuropathol Exp Neurol 67

      Pages: 1063-1071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591023
  • [Journal Article] B cell epitope spreading is a critical step forthe switch from C-protein-induced myocarditis to dilated cardiomyopathy.2007

    • Author(s)
      Matsumoto, Y., Park, I., Kohyama, K.
    • Journal Title

      Am. J. Pathol. 170・(1)

      Pages: 43-51

    • Data Source
      KAKENHI-PROJECT-18790519
  • [Journal Article] Quantitationofmyelinoligodendrocyteglycoproteinandmyelin basic protein in the thymus and central nervous system and its relationship to the clinicopathological features of autoimmune encephalomyelitis.2006

    • Author(s)
      Sakuma, H., Park, I., Kohyama, K., Feng, D., Matsumoto, Y.
    • Journal Title

      J. Neurosci. Res. 84・(3)

      Pages: 606-613

    • Data Source
      KAKENHI-PROJECT-18790519
  • [Journal Article] Non-viral A beta DNA vaccine therapy against Alzheimer's disease: Long term-effects and safety2006

    • Author(s)
      Okura, Y., Miyakoshi, A., Kohyama, K., Staufenbiel, M., Matsumoto, Y.
    • Journal Title

      Proc Natl Acad Sci USA 103

      Pages: 9619-9624

    • Data Source
      KAKENHI-PROJECT-19591023
  • [Journal Article] Non-viral A beta DNA vaccine therapy against Alzheimer's disease : Long term-effects and safety2006

    • Author(s)
      Okura, Y., Miyakoshi, A., Kohyama, K., Staufenbiel, M., Matsumoto, Y
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 9619-9624

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590909
  • [Journal Article] Non-viral A beta DNA vaccine therapy against Alzheimer's disease : Long term-effects and safety2006

    • Author(s)
      Okura, Y., Miyakoshi, A., Kohyama, K., Staufenbiel, M., Matsumoto, Y
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 9619-9624

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590909
  • [Journal Article] アルツハイマー病に対する非ウイルス性Aβ-DNAワクチン療法の開発2005

    • Author(s)
      大倉良夫, 宮越陽, 神山邦子, Matthias Staufenbiel, 松本陽
    • Journal Title

      Dementia Japan 13

      Pages: 36-36

    • Data Source
      KAKENHI-PROJECT-17590909
  • [Journal Article] Characterization of relapsing autoimmune encephalomyelitis and its treatment with decoy chemokine receptor gene2005

    • Author(s)
      Matsumoto, Y., Sakuma, H., Miyakoshi, A., Tsukada, Y., Kohyama, K., Park, I., Naoyuki, T.
    • Journal Title

      J.Neuroimmunol. 170

      Pages: 49-61

    • Data Source
      KAKENHI-PROJECT-17590909
  • [Presentation] Aベータ亜種、及びアミロイド原性脳内蛋白に対応する非ウイルス性DNAワクチンの開発2010

    • Author(s)
      松本陽、神山邦子、加地健太郎
    • Organizer
      日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-21591103
  • [Presentation] 老齢アカゲザルを用いたアルツハイマー病に対する非ウイルス性DNAワクチンの薬効と安全性試験2009

    • Author(s)
      松本陽、時田偉子、神山邦子、大倉良夫
    • Organizer
      第21回日本神経免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-15
    • Data Source
      KAKENHI-PROJECT-21591103
  • [Presentation] アルツハイマー病に対する非ウイルス性DNAワクチン療法の作用機序に関する解析2008

    • Author(s)
      松本陽, 大倉良夫, 神山邦子, 平木啓子
    • Organizer
      日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2008-04-12
    • Data Source
      KAKENHI-PROJECT-19591023
  • [Presentation] ラット心筋炎におけるマトリクスメタロプロテアーゼ(MMP)産生細胞の特性解析2007

    • Author(s)
      神山 邦子
    • Organizer
      第37回日本菟疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Data Source
      KAKENHI-PROJECT-18790519
  • [Presentation] アルツハイマー病に対する非ウイルス性DNAワクチン療法の作用機序に関する解析2007

    • Author(s)
      松本陽、大倉良夫、神山邦子、平木啓子
    • Organizer
      第19回日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-19591023
  • [Presentation] アルツハイマー病に対する非ウイルス性DNAワクチン療法の効果と作用機序に関する解析2007

    • Author(s)
      松本陽、大倉良夫、朴一権、神山邦子
    • Organizer
      第48回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591023
  • [Presentation] アルツハイマー病に対する非ウイルス性DNAワクチン療法の作用機序に関する解析2007

    • Author(s)
      松本 陽, 大倉 良夫, 神山 邦子, 平木 啓子
    • Organizer
      日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Data Source
      KAKENHI-PROJECT-19591023
  • 1.  MATSUMOTO Yoh (90173921)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 15 results
  • 2.  TANUMA Naoyuki (00281676)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  OKURA Yosio (10392367)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 4.  MATSUBARA Shiro (00143884)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  WARABI Yoko (30399464)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KOHYAMA Kuniok (83031795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NIIMI Naoko (90405043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KAWAZOE Yoko (60281705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  小島 崇 (30225429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  佐久間 啓
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  尹 元基
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  池 映欣
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  JEE Youngheun
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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