OKURA Takashi 黄倉崇

… Alternative Names

黄倉崇オオクラタカシ

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Researcher Number	80326123
Other IDs
Affiliation (Current)	2025: 帝京大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 帝京大学, 薬学部, 教授 2016 – 2023: 帝京大学, 薬学部, 教授 2010 – 2015: Teikyo University, 薬学部, 准教授 2007 – 2009: Teikyo University, 薬学部, 講師 2004 – 2006: 帝京大学, 薬学部, 助手 2002 – 2003: 静岡県立大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学 Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator 血液脳関門 / トランスポーター / オキシコドン / 有機カチオン / 相互作用 / 薬物動態学 / 鎮痛補助薬 / 受容体占有 / 薬歴データベース / 薬剤性認知機能障害 … More / ポリファーマシー / 認知機能障害 / 認知症 / 過活動膀胱治療薬 / 抗コリン薬 / 過活動膀胱 / ムスカリン受容体 / 受容体占有率 / 薬剤服用歴情報 / 脳微小透析法 / オピオイド受容体 / オピオイド鎮痛薬 / オピオイド / transporter / opioid / siRNA / OCTN2 / carnitne / organic cation / blood-brain barrier / 交換輸送体 / カチオン / 鎮痛薬 / RNA干渉 / 脳移行 / プロトンアンチポーター / ヒト / 脳関門 / アミトリプチリン / オキシコン / モノアミン / PMAT / 脳内分布 / 脊髄 / 鎮痛作用 / モルヒネ-6-グルクロナイド / 膜透過 / P糖タンパク質 / グルタミン酸 / 微小透析法 / 鎮痛耐性 / モルヒネ … More Except Principal Investigator トランスポーター / 血液脳関門 / 血液脳関門モデル細胞 / ヒト血液脳関門モデル細胞 / ヒト脳移行性 / 有機カチオン性薬物 / 有機カチオントランスポーター / 有機カチオン-プロトン交換輸送系 / ヒトiPS細胞 / 塩基性薬物 / 基質認識性 / ヒト不死化脳毛細血管内皮細胞 / ヒトiPS細胞由来脳毛細血管内皮細胞 / プロトン-有機カチオン交換輸送系 / ヒトiPS由来脳毛細血管内皮細胞 / ヒト脳毛細血管モデル / 薬物認識性 / 有機カチオン輸送系 / フロー培養システム / 循環培養システム / 発現解析 / 輸送特性 / 遺伝子抑制 / RNAiライブラリー / ヒト由来不死化細胞株 / スケールアップ / 遺伝子解析 / 脳移行性 / カチオン性薬物 / ヒト細胞株 / OCTN2 / siRNA / TR-BBB13 / PMAT / モノアミン / 有機カチオン性物質 / PAMT / ピリラミン / 不死化細胞株 / 薬物動態学 Less

薬剤性認知症回避を目指した抗コリン薬の新規リスク指標開発Principal Investigator
- Principal Investigator
  
  黄倉崇
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo University
Clinical-basic integrated research on drug interactions for preventing dementia caused by polypharmacyPrincipal Investigator
- Principal Investigator
  
  Okura Takashi
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo University
Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrier
- Principal Investigator
  
  Deguchi Yoshiharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesicsPrincipal Investigator
- Principal Investigator
  
  Okura Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human
- Principal Investigator
  
  DEGUCHI YOSHIHARU
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in the Central Nervous SystemPrincipal Investigator
- Principal Investigator
  
  OKURA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Prediction of the human brain distribution for the central nervous system drugs using a novel human immortalized brain capillary endothelial cells
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Transport mechanisms of opioid analgesics across the blood-brain barrierPrincipal Investigator
- Principal Investigator
  
  OKURA Takashi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Identification and Functional Characterization of Pyrilamine Transporter, an Organic Cation Transporter
- Principal Investigator
  
  DEGUCHI Yoshlharu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Blood-brain barrier transport of opioid agonists mediated by organic cation-sensitive transporterPrincipal Investigator
- Principal Investigator
  
  OKURA Takashi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
麻薬性鎮痛薬の適正使用を指向した生体内動態と鎮痛作用の統合的研究Principal Investigator
- Principal Investigator
  
  黄倉崇
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
微小透析法を用いたオピオイド鎮痛薬の作用部位における薬物濃度と薬理作用の解析Principal Investigator
- Principal Investigator
  
  黄倉崇
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Teikyo University
  University of Shizuoka

[Book] 薬物分布実験法　脳関門2014
- Author(s)
  黄倉崇、出口芳春
- Total Pages
  13
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25460199
[Book] 細胞工学　トロイの木馬抗体を用いた中枢作用型タンパク質・遺伝子医薬開発の最前線2013
- Author(s)
  黄倉崇、出口芳春
- Total Pages
  2
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-25460199
[Book] コンパス生物薬剤学2010
- Author(s)
  岩城正宏、伊藤智夫編、黄倉崇, 他
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21790162
[Book] オピオイド研究の進歩と展望(鎮痛薬・オピオイドペプチド研究会編)2004
- Author(s)
  黄倉崇, 山田静雄
- Total Pages
  7
- Publisher
  ネオメディカル
- Data Source
  KAKENHI-PROJECT-14771338
[Journal Article] Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model2015
- Author(s)
  Higuchi K, Kitamura A, Okura T, Deguchi Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 30 Issue: 2 Pages: 182-187
- DOI
  10.1016/j.dmpk.2014.12.006
- NAID
  210000180315
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460199
[Journal Article] The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in CNS2015
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 135 Issue: 5 Pages: 697-702
- DOI
  10.1248/yakushi.14-00234-2
- NAID
  130005066918
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2015-05-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-15K08080, KAKENHI-PROJECT-25460199
[Journal Article] Proton-Coupled Organic Cation Antiporter-Mediated Uptake of Apomorphine Enantiomers in Human Brain Capillary Endothelial Cell Line hCMEC/D32014
- Author(s)
  Okura T, Higuchi K, Kitamura A, Deguchi Y
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 2 Pages: 286-291
- DOI
  10.1248/bpb.b13-00773
- NAID
  130003382121
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-25460199
[Journal Article] Endothelin-1 Receptors in Rat Tissues: Characterization by Bosentan, Ambrisentan and CI-10202014
- Author(s)
  Yokoyama Y, Osano A, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 3 Pages: 461-465
- DOI
  10.1248/bpb.b13-00881
- NAID
  130003390952
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460199
[Journal Article] Functional Expression of Organic Cation/carnitine Transporter 2 (OCTN2/<i>SLC22A5)</i> in Human Brain Capillary Endothelial Cell Line hCMEC/D3, a Human Blood-brain Barrier Model2014
- Author(s)
  Okura T, Kato S, Deguchi Y
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29 Issue: 1 Pages: 69-74
- DOI
  10.2133/dmpk.DMPK-13-RG-058
- NAID
  130004463347
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-25460199
[Journal Article] Functional expression of a protoncoupled organic cation (H^+/OC) antiporter in humam brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model2013
- Author(s)
  Shimomura K, Okura T, Deguchi Y, et al
- Journal Title
  
  Fluids. Barrier. CNS
  
  Volume: 10:8 Pages: 1-10
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo.2011
- Author(s)
  Muhammad Waqas Sadiq, Takashi Okura, et al
- Journal Title
  
  J.Pharm.Sci.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Functional characterization of rat plasma membrane monoamine transporter (PMAT) in the blood-brain and blood-cerebrospinal fluid barriers.2011
- Author(s)
  Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguchi
- Journal Title
  
  J.Pharm.Sci. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo.2011
- Author(s)
  Muhammad Waqas Sadiq, Annika Borgs, Takashi Okura, Keita Shimomura, Sayaka Kato, Yoshiharu Deguchi, Britt Janssonl, Sven Bjorkman, Tetsuya Terasaki, Margareta Hammarlund-Udenaes
- Journal Title
  
  J.Pharm.Sci. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers2011
- Author(s)
  Okura T and Deguchi Y et al
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 100 Pages: 3923-3938
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.2010
- Author(s)
  Yusuke Nakazawa, Takashi Okura, et al
- Journal Title
  
  J.Pharm.Sci. 99
  
  Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.2010
- Author(s)
  Takashi Okura, et al
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 255-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Muscarinic receptor binding and plasma drug concentration after oral administration of propiverine in mice.2010
- Author(s)
  Yoshihiko Ito, Takashi Okura, et al
- Journal Title
  
  Lower Urinary Tract Symptoms
  
  Volume: 2 Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier and antinociceptive effect2010
- Author(s)
  Okura T, and Deguchi Y, et al
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 99 Pages: 467-474
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] A possible mechanism for the decrease in serum thyroxine level by a TCDD-like PCB congener, 3,3',4,4',5- pentachlorobiphenyl in mice.2010
- Author(s)
  Yoshihisa Kato, Takashi Okura, et al
- Journal Title
  
  Drug Metab. Dispos. 38
  
  Pages: 150-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.2010
- Author(s)
  Takashi Okura, Michiko Ibe, Keizo Umegaki, Kazumasa Shinozuka, Shizuo Yamada
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 255-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.2010
- Author(s)
  Yusuke Nakazawa, Takashi Okura, Keita Shimomura, Tetsuya Terasaki, Yoshiharu Deguchi
- Journal Title
  
  J.Pharm.Sci. 99
  
  Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier and antinociceptive effect.2010
- Author(s)
  Okura T, Deguchi Y, et al.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 99 Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590144
[Journal Article] Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine.2009
- Author(s)
  Takashi Okura, Tadahiro Ozawa, Michiko Ibe, Yuko Taki, Midori Kimura, Yoshiyuki Kagawa, Yoshihisa Kato, Shizuo Yamada
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1571-1575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Effects of quinidine on antinociception and pharmacokinetics of morphine in rats2009
- Author(s)
  Takashi Okura, Yuki Morita, Yoshihiko Ito, Yoshiyuki Kagawa, Shizuo Yamada
- Journal Title
  
  J. Pharm. Pharmacol 61
  
  Pages: 593-597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine.2009
- Author(s)
  Takashi Okura, et al
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1571-1575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Effects of quinidine on antinociception and pharmacokinetics of morphine in rats.2009
- Author(s)
  Takashi Okura, Yuki Morita, Yoshihiko Ito, Yoshiyuki Kagawa, Shizuo Yamada
- Journal Title
  
  J.Pharm.Pharmacol. 61
  
  Pages: 593-597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Effects of quinidine on antinociception and pharmacokinetics of morphinem rats.2009
- Author(s)
  Takashi Okura, et al
- Journal Title
  
  J.Pharm.Pharmacol. 61
  
  Pages: 593-597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790162
[Journal Article] Effects of quinidine on antinociception and pharmacokinetics of morphine in rats2009
- Author(s)
  Takashi Okura, et.al.
- Journal Title
  
  J. Pharm. Pharmacol (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxvcodone2008
- Author(s)
  Takashi Okura, et.al.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 2005-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone2008
- Author(s)
  Takashi Okura, Asami Hattori, Yusuke Takano, Takenori Sato, Margareta Hammarlund- Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 2005-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone2008
- Author(s)
  Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 2005-2005
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Enhancement by grapefruit juice of morphine antinociception2008
- Author(s)
  Takashi Okura, et.al.
- Journal Title
  
  Biol. Pharm. Bull 31
  
  Pages: 2338-2341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Involvement of the pyrilamine transporter, a putative organic cationtransporter, in blood-brain barrier transport of oxycodone.2008
- Author(s)
  Okura T, Deguchi Y, et al.
- Journal Title
  
  Drug Metab. Dispos. 36
  
  Pages: 2005-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Enhancement by grapefruit juice of morphine antinociception2008
- Author(s)
  Takashi Okura, Tadahiro Ozawa, Yoshihiko Ito, Midori Kimura, Yoshiyuki Kagawa, Shizuo Yamada
- Journal Title
  
  Biol. Pharm. Bull 31
  
  Pages: 2338-2341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Comparative evaluation of antinociceptive potency of morphine and morphine-6β-glucuronide by simultaneous measurements of spinal concentration.2007
- Author(s)
  Takashi Okura
- Journal Title
  
  Life Sciences (in press)
  
  Pages: 8-8
- Data Source
  KAKENHI-PROJECT-17790131
[Journal Article] Prediction of α_1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.2007
- Author(s)
  Shizuo, Yamada・Takashi, Okura, et. al.
- Journal Title
  
  Biol. Pharm. Bull. 30
  
  Pages: 1237-1241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790136
[Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D_2 agonist.2007
- Author(s)
  Takashi Okura
- Journal Title
  
  Life Sciences (in press)
  
  Pages: 8-8
- Data Source
  KAKENHI-PROJECT-17790131
[Journal Article] Comparative evaluation of antinociceptive potency of morphine and morphine-6ss-glucuronide by simultaneous measurements of spinal concentration2007
- Author(s)
  Okura T, Komiyama N, Morita Y, Deguchi Y, Yamada S.
- Journal Title
  
  Life Sci 80
  
  Pages: 1319-1319
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D2 agonist2007
- Author(s)
  Okura T. Ito R, Ishiguro N, Tamai I, Deguchi Y.
- Journal Title
  
  Life Sci. 80
  
  Pages: 1564-1564
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Different effects of morphine and morphine-6β-glucuronide on formalin-evoked spinal glutamate release in conscious and freely-moving rats.2007
- Author(s)
  Takashi Okura
- Journal Title
  
  Neuroscience Letters (in press)
  
  Pages: 5-5
- Data Source
  KAKENHI-PROJECT-17790131
[Journal Article] Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6b-glucuronide in rats2007
- Author(s)
  Okura T, Deguchi Y, et. al.
- Journal Title
  
  Life Science 80
  
  Pages: 1319-1326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590161
[Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D2 agonist2007
- Author(s)
  Okura T, Deguchi Y, et. al.
- Journal Title
  
  Life Science 80
  
  Pages: 1564-1571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 過活動膀胱抗ムスカリン薬の認知症関連有害事象の医薬品副作用データベース解析とラット脳内ムスカリン受容体占有解析2023
- Author(s)
  志保美月、田中紫茉子、赤下学、中谷絵理子、黄倉崇
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] Pharmacokinetic and pharmacodynamic interactions of levomepromazine with risperidone or quetiapine in rats2022
- Author(s)
  Gaku Akashita, Eriko Nakatani, Takashi Okura
- Organizer
  第37回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] 薬剤服用歴情報を用いた過活動膀胱治療薬の認知症発症リスク評価2022
- Author(s)
  古川正樹、赤下学、山戸淳、熊谷瞬、中谷絵理子、志保美月、黄倉崇
- Organizer
  第55回日本薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] Prediction of muscarinic receptor occupancy in the human bladder and parotid gland from plasma and urinary concentrations of antimuscarinic agents used to treat overactive bladder2022
- Author(s)
  Mizuki Shiho, Anna Ishii, Gaku Akashita, Eriko Nakatani, Shimako Tanaka, Shizuo Yamada, Takashi Okura
- Organizer
  第37回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] 過活動膀胱治療薬の尿中排泄とムスカリン受容体占有率予測に基づく膀胱選択性評価2021
- Author(s)
  黄倉　崇、志保美月、石井杏奈、赤下　学、中谷絵理子、山田静雄
- Organizer
  第28回日本排尿機能学会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] Prediction of muscarinic receptor occupancy and bladder selectivity based on urinary concentrations of antimuscarinic agents to treat overactive bladder.2021
- Author(s)
  Mizuki Shiho, Anna Ishii, Gaku Akashita, Eriko Nakatani, Shizuo Yamada, Takashi Okura
- Organizer
  第36回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] ポリファーマシーの相互作用メカニズム解明を目指した臨床と基礎の薬剤学的統合研究2020
- Author(s)
  黄倉　崇、志保美月、中谷絵理子、赤下学、山田静雄
- Organizer
  第30回日本医療薬学会年会シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] LC-MS/MSを用いた抗精神病薬の標的となる複数受容体の同時測定法の開発2020
- Author(s)
  林　祐輔、櫻井誉子、赤下　学、中谷絵理子、伊藤拓海、小高　竣、黄倉　崇
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] 過活動膀胱治療薬の尿中薬物濃度に基づいた膀胱受容体占有率の予測2020
- Author(s)
  伊藤拓海、赤下学、岩切孝樹、中谷絵理子、山田静雄、黄倉崇
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] 服用時点変更による高齢者施設における服薬介助の適正化の可能性2019
- Author(s)
  島袋智生、中谷絵理子、杉本修康、原　和夫、臼井順信、黄倉　崇
- Organizer
  第3回日本老年薬学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] 過活動膀胱治療薬のムスカリン性受容体結合活性および生体内薬物濃度に基づくヒト膀胱と耳下腺の受容体占有率の予測2019
- Author(s)
  黄倉　崇、赤下　学、岩切孝樹、中谷絵理子、山田静雄
- Organizer
  第26回日本排尿機能学会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] 多剤併用による副作用発現回避を目指した臨床-基礎融合研究による相互作用解析法の確立2019
- Author(s)
  中谷絵理子、轟　涼介、島袋智生、樋口一樹、原　和夫、臼井順信、山田静雄、黄倉　崇
- Organizer
  第3回日本老年薬学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06796
[Presentation] Characterization of mesoridazine transport in human cerebral microvessel endothelial cells, hCMEC/D32018
- Author(s)
  6.Yasuyuki Debori1, Tomoko Igari, Masanori Nakakariya, Nobuyuki Amano, Yuma Tega, Kei Higuchi, Takashi Okura and Yoshiharu Deguchi
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門プロトン/有機カチオンアンチポーターの機能制御因子の解析2017
- Author(s)
  樋口　慧、近藤麻美、上松祐貴、黒澤俊樹、黄倉　崇、出口芳春
- Organizer
  日本薬学会第137年回
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門プロトン/有機カチオンアンチポーターの機能制御因子の解析2017
- Author(s)
  〇樋口　慧、近藤麻美、上松祐貴、黒澤俊樹、黄倉　崇、出口芳春
- Organizer
  日本薬学会第137年会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] 血液脳関門におけるバレニクリンの輸送解析2016
- Author(s)
  樋口　慧、黒澤俊樹、黄倉　崇、楠原洋之、出口芳春
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム（名古屋）
- Place of Presentation
  名古屋
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Transport characteristics of varenicline in the blood-brain barrier2016
- Author(s)
  Kurosawa T, Higuchi K, Okura T, Kusuhara H, Deguchi Y.
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  長野県松本市キッセイ文化ホール
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Transport characteristics of varenicline in the blood-brain barrier2016
- Author(s)
  Toshiki Kurosawa, Kei Higuchi, Takashi Okura, Hiroyuki Kusuhara, and Yoshiharu Deguchi
- Organizer
  第31日本薬物動態学会年会（松本）
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Histamine H1-receptor signaling in human blood-brain barrier cells2015
- Author(s)
  Takashi Okura, Kei Higuchi, Manami Ueno , Hironao Ito, Asami Kondo, Yoshiharu Deguchi
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Blood-to-brain transport of apomorphine enantiomers by proton-coupled organic cation antiporter at the blood-brain barrier2015
- Author(s)
  Okura T, Higuchi K, Kitamura A, Deguchi Y
- Organizer
  11th International Conference on Cerebral Vascular Biology
- Place of Presentation
  Paris (France)
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Gene expression profiles in hCMEC/D3 cells with different transport activities of proton/organic cation antiporter2015
- Author(s)
  Kei Higuchi, Takashi Okura, Yuki Uematsu, Asami Kondo, Hironao Ito, Yoshiharu Deguchi
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Histamine H1-receptor signaling in human blood-brain barrier cells2015
- Author(s)
  Okura T, Higuchi K, Ueno M, Ito H, Kondo A, Deguchi Y
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Analysis of gene expression profiles related to the transport activity of the proton/organic cation antiport system in hCMEC/D3 cells2015
- Author(s)
  Higuchi K, Okura T, Uematsu Y, Kondo A, Ito H, Deguchi Y
- Organizer
  Barcelona BioMed Conference, Blood Brain Barrier
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2015-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Gene expression profiles in hCMEC/D3 cells with different transport activities of proton/organic cation antiporter2015
- Author(s)
  Higuchi K, Okura T, Uematsu Y, Kondo A, Ito H, Deguchi Y
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Memantine uptake mediated by a functionally diverse proton-coupled organic cation antiporter in human brain endothelial cells2015
- Author(s)
  Higuchi K, Okura T, Deguchi Y
- Organizer
  The Asian Federation for Pharmaceutical Sciences (AFPS) Conference 2015
- Place of Presentation
  Bangkok (Thailand)
- Year and Date
  2015-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Involvement of functionally diverse proton-coupled organic cation antiporter in blood-brain barrier transport of memantine2015
- Author(s)
  Kei Higuchi, Atsushi Kitamura, Takashi Okura, Yoshiharu Deguchi
- Organizer
  11th Cerebral Vascular Biology International Conference
- Place of Presentation
  パリ
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Blood-to-brain transport of apomorphine enantiomers by proton-coupled organic cation antiporter at the blood-brain barrier2015
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  11th Cerebral Vascular Biology International Conference
- Place of Presentation
  パリ
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Involvement of functionally diverse proton-coupled organic cation antiporter in blood-brain barrier transport of memantine2015
- Author(s)
  Higuchi K, Kitamura A, Okura T, Deguchi Y
- Organizer
  11th International Conference on Cerebral Vascular Biology
- Place of Presentation
  Paris (France)
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 麻薬性鎮痛薬の中枢効果を制御する血液脳関門輸送機構2014
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Organizer
  日本薬学会第134年会シンポジウム
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] アポモルヒネの高い脳移行性を担う血液脳関門輸送のインビボ解析2014
- Author(s)
  黄倉　崇、佐藤樹夏、樋口　慧、北村　敦、柄谷礼人、久保敬史、小林俊生、櫻庭美菜子、出口芳春
- Organizer
  第58回薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] hCMEC/D3細胞を用いたカクテル法によるH+/有機カチオン交換輸送体基質探索の基礎的検討2014
- Author(s)
  樋口　慧、北村　敦、黄倉　崇、出口芳春
- Organizer
  日本薬学会第13４年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 脳マイクロダイアリシス法による薬物カクテルの脳移行性評価2014
- Author(s)
  北村敦、黒澤俊樹、樋口慧、黄倉崇、福島貴人、祖父江佳奈、出口芳春
- Organizer
  第58回薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] A proton-coupled organic cation antiporter mediated transport of apomorphine in human brain endothelial cell line hCMEC/D32013
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] R(-)-Apomorphine transport into human brain endothelial cells by a proton-coupled organic cation antiporter2013
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第28回日本薬物動態学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] ヒト血液脳関門におけるアポモルヒネのプロトン交換輸送機構2013
- Author(s)
  黄倉　崇、樋口慧、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインク愛知（名古屋）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] トランスポーターを利用した薬物の脳移行　－ヒト血液脳関門におけるメマンチンの輸送機構解析－2013
- Author(s)
  樋口　慧、黄倉　崇、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインク愛知（名古屋）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] ヒト血液脳関門におけるアポモルヒネのプロトン交換輸送機構2013
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] ヒト血液脳関門細胞hCMEC/D3におけるメマンチンの輸送特性2013
- Author(s)
  樋口　慧、北村敦、黄倉　崇、出口芳春
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Investigation of the organic cation/carnitine transporter in human brain endothelial cells by small interfering RNA2012
- Author(s)
  Okura T and Deguchi Y
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞(hCMEC/D3) を用いた有機カチオン/カルニチントランスポーターの機能解析2012
- Author(s)
  黄倉崇、加藤清香、出口芳春
- Organizer
  日本薬剤学会第27 年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株（hCMEC/D3）を用いた有機カチオン/カルニチントランスポーターの機能解析2012
- Author(s)
  黄倉　崇、加藤清香、出口芳春
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] Investigation of the organic cation/carnitine transporter in human brain endothelial cells by small interfering RNA2012
- Author(s)
  Takashi Okura, Yoshiharu Deguchi
- Organizer
  第27回日本薬物動態学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] ヒト脳毛細血管内皮細胞株 hCMEC/D3 を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉崇、樋口慧、出口芳春ら
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株hCMEC/D3を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉　崇、下村慶太、樋口慧、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] ヒト脳毛細血管内皮細胞(hCMEC/D3)を用いた有機カチオン/カルニチントランスポーターの機能解析2012
- Author(s)
  黄倉崇、加藤清香、出口芳春
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト脳毛細血管内皮細胞株hCMEC/D3を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉崇、下村慶太、樋口　慧、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA干渉法を用いたヒト血液脳関門細胞における有機カチオン輸送体の機能解析2011
- Author(s)
  黄倉崇、加藤清香、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] ヒト血液脳関門細胞における有機カチオン関連トランスポーターの発現と機能2011
- Author(s)
  黄倉崇、出口芳春, ら
- Organizer
  日本薬学会131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA干渉法を用いたヒト血液脳関門細胞における有機カチオン輸送体の機能解析2011
- Author(s)
  黄倉崇、出口芳春, ら
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA 干渉法を用いたヒト血液脳関門細胞で機能する有機カチオン輸送体の探索2011
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA 干渉法を用いたヒト血液脳関門細胞における有機カチオン輸送体の機能解析2011
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  日本薬剤学会第26 年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒト血液脳関門細胞における有機カチオン関連トランスポーターの発現と機能2011
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  日本薬学会 131 年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] RNA干渉法を用いたヒト血液脳関門細胞で機能する有機カチオン輸送体の探索2011
- Author(s)
  黄倉崇、出口芳春, ら
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] 脳関門システムにおけるカチオントランスポーターの局在解析2011
- Author(s)
  森本理代、加藤清香、黄倉崇、加藤将夫、森山芳則、出口芳春
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] ヒト血液脳関門細胞における有機カチオン関連トランスポーターの発現と機能2011
- Author(s)
  黄倉崇、加藤清香、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] オキシコドンの薬効発現に寄与する血液脳関門のトランスポーター2010
- Author(s)
  黄倉崇、加藤清香、Pierre-Olver Couraud, 出口芳春
- Organizer
  第4回日本緩和医療薬学会年会
- Place of Presentation
  鹿児島
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] RNA interference of organic cation transporters in hCMEC/D3 human brain endothelial cells.2010
- Author(s)
  Takashi Okura, Sayaka Kato, Yoshiharu Deguchi
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] ヒト血液脳関門細胞を用いた有機カチオン/プロトン交換輸送体の機能解析2010
- Author(s)
  下村慶太、黄倉崇、加藤清香、Pierre-Oliver Couraud, 寺崎哲也、出口芳春
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Involvement of an organic cation/proton antiporter in transport of clinically-used cationic drugs in the human brain endothelial cell line (hCMEC/D3)2010
- Author(s)
  Takashi Okura, Sayaka Kato, Keita Shimomura, Pierre-Oliver Couraud, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Transport of uric acid across brain barrier system.2010
- Author(s)
  Sayaka Kato, Takashi Okura, Yoshiharu Deguchi
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] RNA interference of organic cation transporters in hCMEC/D3 human brain endothelial cells2010
- Author(s)
  Takashi Okura, et al
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Drug-drug interactions between oxycodone and adjuvant analgesics at the blood-brain barrier2009
- Author(s)
  Takashi Okura, Yusuke Nakazawa, Asami Hattori, Tetsuya Terasaki and Yoshiharu Deguchi
- Organizer
  8th ISSX/22th JSSX Joint Meeting
- Place of Presentation
  abstract
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Organic cation transport across the blood-brain barrier.2009
- Author(s)
  Takashi Okura, Yoshiharu Deguchi
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] ラット脳関門における有機カチオントランスポーターPMATの発現解析2009
- Author(s)
  加藤清香、黄倉崇、佐藤武則、若山友彦、大槻純男、寺崎哲也、出口芳春
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Characterization of the CNS-acting cationic drug transport at the human blood-brain barrier using human immortalized brain capillary endothelial cells (hCMEC/D3)2009
- Author(s)
  Keita Shimomura, Takashi Okura, et al
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] The human blood-brain barrier in vitro model (hCMEC/D3) expresses functionally active organic cation/proton antiporter for CNS-acting cationic drugs2009
- Author(s)
  Takashi Okura, et al
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] ヒト血液脳関門モデル細胞を用いた有機カチオン性薬物の輸送解析2009
- Author(s)
  下村慶太、黄倉崇、加藤清香、Margareta Hammarlund-Udenaes, 寺崎哲也、出口芳春
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Transport function and expression of PMAT in brain barrier system2009
- Author(s)
  Sayaka Kato, Takashi Okura, et al
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Characterization of the CNS-acting cationic drug transport at the human blood-brain barrier using human immortalized brain capillary endothelial cells (hCMEC/D3).2009
- Author(s)
  Keita Shimomura, Takashi Okura, Sayaka Kato, Margareta Hammarlund-Udenaes, Pierre-Oliver Couraud, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] The human blood-brain barrier in vitro model (hCMEC/D3) expresses functionally active organic cation/proton antiporter for CNS- acting cationic drugs.2009
- Author(s)
  Takashi Okura, Keita Shimomura, Sayaka Kato, Pierre-Oliver Couraud, Margareta Hammarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Organic cation transport across the blood-brain barrier(招待講演)2009
- Author(s)
  Takashi Okura, Yoshiharu Deguchi
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Transport function and expression of PMAT in brain barrier system.2009
- Author(s)
  Sayaka Kato, Takashi Okura, Takenori Sato, Tomohiko Wakayama, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-21790162
[Presentation] Blood-brain barrier transport and pharmacological effect of opioids2008
- Author(s)
  Takashi Okura, Asami Hattori, Yusuke Takano, Takenori Sato, Margareta Hammarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  11th International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  Amsterdam
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Expression and functional characterization of plasma membrane monoamine transporter (PMAT) in therat blood-brain barrier2008
- Author(s)
  Yoshiharu Deguchi, Takashi Okura, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Sumio Ohtsuki, Tetsuya Terasaki
- Organizer
  11th International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  Amsterdam
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Plasma membrane monoamine transporter (PMAT) mediates the efflux t ransport of organic cations in the brain barrier system2008
- Author(s)
  Takenori Sato, Takashi Okura, et.al.
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Expression and functional characterization of plasma membrane monoamine transporter (PMAT) in the rat blood-brain barrier2008
- Author(s)
  Takenori Sato, Sayaka Kato, Takashi Okura, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] The pyrilamine transporter functions as the multispecific organic cation transporter at the blood-brain barrier2008
- Author(s)
  Takashi Okura, Keita Shimomura, Sayaka Kato, Margareta Hummarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Expression and functional characterization of plasma membrane monoamine transporter (PMAT) in the rat blood-brain barrier2008
- Author(s)
  Yoshiharu Deguchi, Takashi Okura, et.al.
- Organizer
  11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Blood-brain barrier transport and pharmacological effect of opioids2008
- Author(s)
  Takashi Okura, et.al.
- Organizer
  11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] 血液脳関門に高発現する新規有機カチオントランスポーター(PMAT)のクローニングと輸送機能解析2008
- Author(s)
  高野祐輔、黄倉崇、出口芳春ら
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Blood-brain barrier transport and pharmacological effect of opioids2008
- Author(s)
  Takashi Okura, Yoshiharu Deguchi, et al
- Organizer
  11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
- Place of Presentation
  オランダ・アムステルダム
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] カチオントランスポーターPMATの脳関門における発現と輸送機能解析2008
- Author(s)
  佐藤武則、黄倉崇、高野祐輔、山下純、寺崎哲也、出口芳春
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Drug-drug interactions between oxycodone and adjuvant analgesics at the blood-brain barrier2007
- Author(s)
  Takashi Okura, Yusuke Nakazawa, Asami Hattori, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Blood-brain barrier transport of cationic drugs2007
- Author(s)
  Takashi Okura
- Organizer
  APSTJ Global Education Seminar
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] 麻薬性鎮痛薬オキシコドンと鎮痛補助薬の相互作用解析2007
- Author(s)
  黄倉崇、中澤佑介、服部麻美、寺崎哲也、出口芳春
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Blood-brain barrier transport of oxycodone, and opiooid receptor agonist2007
- Author(s)
  Y, Deguchi, ・T, Okura, et. al.
- Organizer
  The 5th International Symposium on Membrane Receptors, Signal Transduction and Drug Action
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Blood-brain barrier transport of cationic drugs2007
- Author(s)
  Takashi, Okura
- Organizer
  APSTJ Global Education Seminar 2007
- Place of Presentation
  東京
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Blood-brain barrier transport of oxycodone, an opioid receptor agonist2007
- Author(s)
  Asami Hattori, Takashi Okura, Yusuke Nakazawa Margareta Hammarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  The 5th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects, Shizuoka p.95
- Place of Presentation
  abstract form
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Drug-drug interactions between oxycodone and adjuvant analgesics at the blood-brain barrier2007
- Author(s)
  Takashi, Okura, et. al.
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] 脳冠門におけるrat plasma membrane transporter (rPMAT)の発現と輸送機能2007
- Author(s)
  黄倉崇, 他
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] Expression and transport function of ratplasma membrane transporter(rPMAT)in the brain barrler system2007
- Author(s)
  黄倉崇、出口芳春ら
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 血液脳関門におけるカチオン性薬物トランスポーターの機能および輸送分子の解析2007
- Author(s)
  出口芳春、黄倉崇、服部麻美、鈴木俊英、寺崎哲也
- Organizer
  講演要旨集.p.405(2007)
- Place of Presentation
  日本薬剤学会(大宮)
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] 麻薬性鎮痛薬オキシコドンと鎮痛補助薬の相互作用解析2007
- Author(s)
  黄倉崇、中澤佑介、服部麻美、寺崎哲也、出口芳春
- Organizer
  講演要旨集, p.343(2007)
- Place of Presentation
  日本薬剤学会(大宮)
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] H+/organic cation antiporter is involved in the blood-brain barrier transport of cationic drugs2007
- Author(s)
  Yoshiharu Deguchi, Takashi Okura, et.al.
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  Kanazawa
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Blood-brain barrier transport of oxycodone, an opioid receptor agonist2007
- Author(s)
  Asami Hattori, Takashi Okura, Yusuke Nakazawa, Margareta Hammarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
- Organizer
  The 5th International Symposium on Membrane Receptors, Signal Transduction and Drug Action
- Place of Presentation
  Shizuoka
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] 脳関門におけるrat plasmame mebrane transporter(rPMAT)の発現と輸送機能2007
- Author(s)
  高野祐輔、黄倉崇、出口芳春ら
- Organizer
  トランスポーター研究会第1回関東部会
- Place of Presentation
  横浜
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19590161
[Presentation] Expression and transport function of rat plasma membrane transporter (rPMAT) in the brain barrier system2007
- Author(s)
  黄倉崇、高野祐輔、佐藤武則、山下純、大槻純男、寺崎哲也、出口芳春
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790136
[Presentation] ヒト血液脳関門のトラマドール輸送における
- Author(s)
  北村　敦、樋口　慧、黄倉　崇、出口　芳春
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学板橋キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] IN VIVO AND IN VITRO TRANSPORT OF APOMORPHINE ENANTIOMERS ACROSS THE BLOOD-BRAIN BARRIER
- Author(s)
  Kitamura A, Higuchi K, Okura T, Deguchi Y
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 脳マイクロダイアリシス法を用いたカクテル投与による薬物の脳移行性評価
- Author(s)
  北村敦、樋口慧、黄倉崇、祖父江佳奈、福島貴人、出口芳春
- Organizer
  日本薬剤学会第29年回
- Place of Presentation
  埼玉
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] A proton-coupled organic cation antiporter mediated transport of apomorphine in human brain capillary endothelial cell line hCMEC/D3
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東北大学片平キャンパス(仙台）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] TRANSPORT CHARACTERISTICS OF TRAMADOL AT THE BLOOD-BRAIN BARRIER
- Author(s)
  Yoshiharu Deguchi, Atsushi Kitamura, Kei Higuchi, Takashi Okura
- Organizer
  19ｔｈ North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] TRANSPORT CHARACTERISTICS OF TRAMADOL AT THE BLOOD-BRAIN BARRIER
- Author(s)
  Deguchi Y, Kitamura A, Higuchi K, Okura T
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] IN VIVO AND IN VITRO TRANSPORT OF APOMORPHINE ENANTIOMERS ACROSS THE BLOOD-BRAIN BARRIER
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  19ｔｈ North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590213
[Presentation] プロトン交換輸送体によるアポモルヒネのヒト血液脳関門輸送
- Author(s)
  黄倉　崇、樋口　慧、北村敦、出口芳春
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀（東京
- Data Source
  KAKENHI-PROJECT-25460199
[]
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1. DEGUCHI Yoshlharu (40254255)

# of Collaborated Projects: 6 results

# of Collaborated Products: 70 results
2. HIGUCHI Kei (10625304)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
3. 平田圭一 (80424852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 中谷絵理子 (90803916)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. KATO Sayaka (70505940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. HOSOYAMADA MAKOTO (00291659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 赤下学 (90781542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. Kawabata Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Yamaguchi Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Kusuhara Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

OKURA Takashi 黄倉 崇

黄倉 崇 オオクラ タカシ

Research Projects

Research Products

Co-Researchers

薬剤性認知症回避を目指した抗コリン薬の新規リスク指標開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical-basic integrated research on drug interactions for preventing dementia caused by polypharmacyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrier

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in the Central Nervous SystemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of the human brain distribution for the central nervous system drugs using a novel human immortalized brain capillary endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transport mechanisms of opioid analgesics across the blood-brain barrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and Functional Characterization of Pyrilamine Transporter, an Organic Cation Transporter

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Blood-brain barrier transport of opioid agonists mediated by organic cation-sensitive transporterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

麻薬性鎮痛薬の適正使用を指向した生体内動態と鎮痛作用の統合的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

微小透析法を用いたオピオイド鎮痛薬の作用部位における薬物濃度と薬理作用の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 薬物分布実験法 脳関門2014

Author(s)

Total Pages

OKURA Takashi 黄倉崇

黄倉崇オオクラタカシ

[Book] 薬物分布実験法　脳関門2014

[Book] 細胞工学　トロイの木馬抗体を用いた中枢作用型タンパク質・遺伝子医薬開発の最前線2013