Rai Tatemitsu 頼建光

… Alternative Names

RAI TATEMITSU 頼建光

RAI Tatemitsu 頼建光

頼建光ライタテミツ

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Researcher Number	80334431
Other IDs	https://orcid.org/0000-0001-7695-778X
Affiliation (Current)	2024: 獨協医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 獨協医科大学, 医学部, 教授 2016 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 2010 – 2013: 東京医科歯科大学, 医学部附属病院, 准教授 2008: Tokyo Medical and Dental University, 医学部附属病院, 准教授 2006 – 2007: 東京医科歯科大学, 医学部附属病院, 講師 2002 – 2004: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related / Basic Section 52010:General internal medicine-related / Kidney internal medicine Except Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator WNKキナーゼ / NKCC1 / 高血圧 / SPAK / OSR1 / 偽性低アルドステロン症II型 / ループ利尿薬 / FOXO4 / NCC / ユビキチン … More / Cullin3 / KLHL3 / 偽性低アルドステロン血症II型 / 遺伝子改変マウス / ノックアウトマウス / アクアポリン2 / Na-K-2Cl共輸送体1 (NKCC1) / Na-K-Cl共輸送体1 (NKCC1) / 慢性腎臓病 / BMI / 体格指数 / シグナル伝達 / トランスレーショナルリサーチ / 生理学 / 内科 / PHAII / サルコペニア / 偽性低アルドステロン症II型（PHAII） / cullin3 / ELISA / Slc12a輸送体 / 蛍光相関分光法 / NKCC2 / SLC12A輸送体 / 遺伝性高血圧 / Na-Cl共輸送体(NCC) / Na-K-Cl 共輸送体 / Cullin 3 / angiotensin II / Na-K-Cl共輸送体 / MDCK細胞 / claudin / 偽性低アルドステオン症II型 / Na-Cl共輸送体 / ノックインマウス / 腎臓 / コンディショナルノックアウト / 特異的発現 / トランスジェニックマウス / KLF / 水チャネル / クロライドチャネル … More Except Principal Investigator 脳浮腫治療薬 / 水利尿薬 / 水チャネル阻害薬 / ナノディスク / アクアポリン / 骨格筋 / サルコペニア / 糖尿病性腎症 Less

Novel therapies for chemotherapy-induced fluid disorders via targeting water channelsPrincipal Investigator
- Principal Investigator
  
  頼建光
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Dokkyo Medical University
Elucidating the mechanism of exercise-drug combination in preventing severe diabetic nephropathy
- Principal Investigator
  
  田村由馬
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Dokkyo Medical University
Discovery of direct water channel inhibitors using aquaporin nanodisc technology
- Principal Investigator
  
  野田裕美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the molecular pathogenesis of sarcopenia and development of novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  頼建光
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Dokkyo Medical University
  Tokyo Medical and Dental University
Novel functions and regulation of WNK signaling cascadePrincipal Investigator
- Principal Investigator
  
  Rai Tatemitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Development of novel hypertensive drugs based on inhibition of protein interactionPrincipal Investigator
- Principal Investigator
  
  RAI Tatemitsu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Analysis of WNK-NCC signaling cascade, a novel blood pressure controlling system, in the kidneyPrincipal Investigator
- Principal Investigator
  
  RAI TATEMITSU
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Analysis of WNK kinases and the molecular pathophysiology of hypertensionPrincipal Investigator
- Principal Investigator
  
  RAI Tatemitsu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
腎臓における時間空間的に制御可能な臓器細胞特異的遺伝子変異導入システムの開発Principal Investigator
- Principal Investigator
  
  頼建光
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University

[Journal Article] A case of unexpected diagnosis of fibronectin glomerulopathy with histological features of membranoproliferative glomerulonephritis2024
- Author(s)
  Hata Misa、Mori Takayasu、Hirose Yurika、Nishida Yuriko、Mandai Shintaro、Ando Fumiaki、Susa Koichiro、Iimori Soichiro、Naito Shotaro、Sohara Eisei、Rai Tatemitsu、Taguchi Towako、Tomii Shohei、Ohashi Kenichi、Uchida Shinichi
- Journal Title
  
  BMC Nephrology
  
  Volume: 25 Issue: 1 Pages: 25-25
- DOI
  10.1186/s12882-024-03456-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03556
[Journal Article] Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study2023
- Author(s)
  Mandai S, Koide T, Fujiki T, Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T
- Journal Title
  
  JMA Journal
  
  Volume: 6 Issue: 4 Pages: 404-413
- DOI
  10.31662/jmaj.2022-0188
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2023-10-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03556
[Journal Article] Crescentic glomerulonephritis associated with syphilis: a case report and review of the?literature2023
- Author(s)
  Kaiga Akiko、Sato Yuka、Arakawa Haruna、Rai Tatemitsu、Tojo Akihiro
- Journal Title
  
  Journal of Medical Case Reports
  
  Volume: 17 Issue: 1 Pages: 549-549
- DOI
  10.1186/s13256-023-04293-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03556
[Journal Article] National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 20192023
- Author(s)
  Matsuki Hisazumi、Genma Taku、Mandai Shintaro、Fujiki Tamami、Mori Yutaro、Ando Fumiaki、Mori Takayasu、Susa Koichiro、Iimori Soichiro、Naito Shotaro、Sohara Eisei、Rai Tatemitsu、Fushimi Kiyohide、Uchida Shinichi
- Journal Title
  
  Hypertension
  
  Volume: 80 Issue: 12 Pages: 2591-2600
- DOI
  10.1161/hypertensionaha.123.21880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556
[Journal Article] Generation of NPHP1 knockout human pluripotent stem cells by a practical biallelic gene deletion strategy using CRISPR/Cas9 and ssODN2022
- Author(s)
  Nakano Yuta、Susa Koichiro、Yanagi Tomoki、Hiraoka Yuichi、Suzuki Takefumi、Mori Takayasu、Ando Fumiaki、Mandai Shintaro、Fujiki Tamami、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  In Vitro Cellular & Developmental Biology - Animal
  
  Volume: 58 Issue: 2 Pages: 85-95
- DOI
  10.1007/s11626-022-00655-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21K08223, KAKENHI-PROJECT-19H03672
[Journal Article] Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis2021
- Author(s)
  Fujimaru Takuya、Kawanishi Kunio、et al.
- Journal Title
  
  Kidney International Reports
  
  Volume: 未定 Issue: 5 Pages: 1346-1354
- DOI
  10.1016/j.ekir.2021.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17730, KAKENHI-PROJECT-19K17699, KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-20H03697, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672
[Journal Article] Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney2021
- Author(s)
  Takahashi Naohiro、Kikuchi Hiroaki、Usui Ayaka、Furusho Taisuke、Fujimaru Takuya、Fujiki Tamami、Yanagi Tomoki、Matsuura Yoshiaki、Asano Kenichi、Yamamoto Kouhei、Ando Fumiaki、Susa Koichiro、Mandai Shintaro、Mori Takayasu、Rai Tatemitsu、Uchida Shinichi、Arita Makoto、Sohara Eisei
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 25 Issue: 5 Pages: 445-455
- DOI
  10.1007/s10157-021-02021-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21K06877, KAKENHI-PROJECT-21K16181, KAKENHI-PROJECT-21K20710, KAKENHI-PROJECT-19H03672
[Journal Article] Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)2021
- Author(s)
  Nanamatsu Azuma、Mori Takayasu、Ando Fumiaki、Furusho Taisuke、Mandai Shintaro、Susa Koichiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Hypertension
  
  Volume: epub Issue: 6 Pages: 1953-1963
- DOI
  10.1161/hypertensionaha.121.17127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672
[Journal Article] Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study2021
- Author(s)
  Mandai Shintaro、Ando Fumiaki、Mori Takayasu、Susa Koichiro、Iimori Soichiro、Naito Shotaro、Sohara Eisei、Uchida Shinichi、Fushimi Kiyohide、Rai Tatemitsu
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 11 Pages: 0258846-0258846
- DOI
  10.1371/journal.pone.0258846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03556
[Journal Article] WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages2020
- Author(s)
  Arai Yohei、Asano Kenichi、Mandai Shintaro、Ando Fumiaki、Susa Koichiro、Mori Takayasu、Nomura Naohiro、Rai Tatemitsu、Tanaka Masato、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 533 Issue: 4 Pages: 1290-1297
- DOI
  10.1016/j.bbrc.2020.10.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K16686, KAKENHI-PROJECT-20H03473
[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020
- Author(s)
  Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S
- Journal Title
  
  Kidney International
  
  Volume: 97 Issue: 4 Pages: 713-727
- DOI
  10.1016/j.kint.2019.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672
[Journal Article] Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study2020
- Author(s)
  Mandai Shintaro、Sato Hidehiko、Iimori Soichiro、Naito Shotaro、Tanaka Haruna、Ando Fumiaki、Susa Koichiro、Isobe Kiyoshi、Mori Takayasu、Nomura Naohiro、Sohara Eisei、Okado Tomokazu、Uchida Shinichi、Fushimi Kiyohide、Rai Tatemitsu
- Journal Title
  
  Bone
  
  Volume: 130 Pages: 115122-115122
- DOI
  10.1016/j.bone.2019.115122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K15970
[Journal Article] Phenotypic differences of mutation‐negative cases in Gitelman syndrome clinically diagnosed in adulthood2020
- Author(s)
  Mori Takayasu、Chiga Motoko、Fujimaru Takuya、Kawamoto Ryosuke、Mandai Shintaro、Nanamatsu Azuma、Nomura Naohiro、Ando Fumiaki、Susa Koichiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Human Mutation
  
  Volume: 42 Issue: 3 Pages: 300-309
- DOI
  10.1002/humu.24159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-21K08249
[Journal Article] Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia2020
- Author(s)
  Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S.
- Journal Title
  
  PLoS One.
  
  Volume: 15(6) Issue: 6 Pages: 0235360-0235360
- DOI
  10.1371/journal.pone.0235360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16509, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K23982
[Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease2019
- Author(s)
  Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Kidney international
  
  Volume: 95 Issue: 1 Pages: 123-137
- DOI
  10.1016/j.kint.2018.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H04723
[Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019
- Author(s)
  Matsuura Yoshiaki、Nomura Naohiro、Shoda Wakana、Mori Takayasu、Isobe Kiyoshi、Susa Koichiro、Ando Fumiaki、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Issue: 2 Pages: 364-368
- DOI
  10.1016/j.bbrc.2019.07.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995
[Journal Article] Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation2019
- Author(s)
  Fujiki Tamami、Ando Fumiaki、Murakami Kana、Isobe Kiyoshi、Mori Takayasu、Susa Koichiro、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9245-9245
- DOI
  10.1038/s41598-019-45539-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16501, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970
[Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018
- Author(s)
  Hashimoto Hiroko、Nomura Naohiro、Shoda Wakana、Isobe Kiyoshi、Kikuchi Hiroaki、Yamamoto Kouhei、Fujimaru Takuya、Ando Fumiaki、Mori Takayasu、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Metabolism
  
  Volume: 85 Pages: 23-31
- DOI
  10.1016/j.metabol.2018.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314
[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018
- Author(s)
  Ando Fumiaki、Mori Shuichi、Yui Naofumi、Morimoto Tetsuji、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Sasaki Sei、Kondo Yoshiaki、Kagechika Hiroyuki、Uchida Shinichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1411-1411
- DOI
  10.1038/s41467-018-03771-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-18K08233, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06656, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K09642
[Journal Article] Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo2018
- Author(s)
  Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Bomont P, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Clinical and experimental nephrology
  
  Volume: 22 Issue: 6 Pages: 1251-1257
- DOI
  10.1007/s10157-018-1593-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642
[Journal Article] WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO42018
- Author(s)
  Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S
- Journal Title
  
  Scientific reports
  
  Volume: 8 Issue: 1 Pages: 9101-9101
- DOI
  10.1038/s41598-018-27414-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-16K09642
[Journal Article] Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease2018
- Author(s)
  Ishikawa Seiko、Naito Shotaro、Iimori Soichiro、Takahashi Daiei、Zeniya Moko、Sato Hidehiko、Nomura Naohiro、Sohara Eisei、Okado Tomokazu、Uchida Shinichi、Rai Tatemitsu
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 2 Pages: e0192990-e0192990
- DOI
  10.1371/journal.pone.0192990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09642
[Journal Article] WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL32017
- Author(s)
  Susa Koichiro、Sohara Eisei、Takahashi Daiei、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 491 Issue: 3 Pages: 727-732
- DOI
  10.1016/j.bbrc.2017.07.121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K15467
[Journal Article] 【腎臓学　この一年の進歩】　尿細管生理2017
- Author(s)
  頼建光、内田信一
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 50 Pages: 28-34
- Data Source
  KAKENHI-PROJECT-16K09642
[Journal Article] Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.2017
- Author(s)
  Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487 Issue: 2 Pages: 368-374
- DOI
  10.1016/j.bbrc.2017.04.068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-16K19478
[Journal Article] 【腎臓医が知っておきたい分子遺伝学の進歩】　疾患編 Bartter/Gitelman症候群、Liddle症候群、PHAII2017
- Author(s)
  頼建光
- Journal Title
  
  腎と透析
  
  Volume: 82 Pages: 431-439
- Data Source
  KAKENHI-PROJECT-16K09642
[Journal Article] KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.2017
- Author(s)
  Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 27 Issue: 7 Pages: 1-13
- DOI
  10.1128/mcb.00508-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-16H06772, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-17K16076
[Journal Article] Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells.2017
- Author(s)
  Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 46580-46580
- DOI
  10.1038/srep46580
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15K14431, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642, KAKENHI-PLANNED-26110006, KAKENHI-PROJECT-15H04812, KAKENHI-PROJECT-17H04068
[Journal Article] WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.2017
- Author(s)
  Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S.
- Journal Title
  
  EBioMedicine
  
  Volume: 18 Pages: 118-27
- DOI
  10.1016/j.ebiom.2017.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15H06184, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-17K16077, KAKENHI-PUBLICLY-17H05500, KAKENHI-PROJECT-15K09423, KAKENHI-PROJECT-16K15234
[Journal Article] Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy.2017
- Author(s)
  Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 46369-46369
- DOI
  10.1038/srep46369
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K16489, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642
[Journal Article] Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus2015
- Author(s)
  Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 26 Issue: 9 Pages: 2129-2138
- DOI
  10.1681/asn.2014070639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860628
[Journal Article] Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice2014
- Author(s)
  Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S
- Journal Title
  
  Hum Mol Genet
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168
[Journal Article] WNK4 is the major WNK kinase positively regulating NCC in the mouse kidney2014
- Author(s)
  Takahashi D, Mori T, Nomura N, Khan MZ, Araki Y, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biosci Rep
  
  Volume: 34 (3) Issue: 3 Pages: 195-205
- DOI
  10.1042/bsr20140047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428
[Journal Article] WNK4 is the major WNK kinase positively regulating NCC in the mouse kidney2014
- Author(s)
  Takahashi D, Mori T, Nomura N, Khan MZ, Araki Y, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biosci Rep
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168
[Journal Article] Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters2014
- Author(s)
  Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 26 Issue: 7 Pages: 1525-1536
- DOI
  10.1681/asn.2014060560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-26670428
[Journal Article] Regulation of with-no-lysine kinase signaling by Kelch-like proteins2014
- Author(s)
  Uchida S, Sohara E, Rai T, Sasaki S
- Journal Title
  
  Biol Cell
  
  Volume: 106 (2) Pages: 45-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412
[Journal Article] Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice2014
- Author(s)
  Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 (19) Issue: 19 Pages: 5052-60
- DOI
  10.1093/hmg/ddu217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860628, KAKENHI-PROJECT-221S0001
[Journal Article] Regulation of with-no-lysine kinase signaling by Kelch-like proteins2014
- Author(s)
  Uchida S, Sohara E, Rai T, Sasaki S
- Journal Title
  
  Biol Cell
  
  Volume: 106(2) Issue: 2 Pages: 45-56
- DOI
  10.1111/boc.201300069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II2013
- Author(s)
  Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Hypertension
  
  Volume: 62(5) Issue: 5 Pages: 872-8
- DOI
  10.1161/hypertensionaha.113.01543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23590319, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PUBLICLY-25136722, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25460350, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-25860670
[Journal Article] KLHL2 interacts with and ubiquitinates WNK kinases2013
- Author(s)
  Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 437(3) Issue: 3 Pages: 457-62
- DOI
  10.1016/j.bbrc.2013.06.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement2013
- Author(s)
  Isobe K, Mori T, Asano T, Kawaguchi H, Nonoyama S, Kumagai N, Kamada F, Morimoto T, Hayashi M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 305(9) Issue: 9 Pages: F1374-F1381
- DOI
  10.1152/ajprenal.00208.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24790836
[Journal Article] Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.2013
- Author(s)
  Mori, T.; Kikuchi, E.; Watanabe, Y.; Fujii, S.; Ishigami-Yuasa, M.; Kagechika, H.; Sohara, E.; Rai, T.; Sasaki, S.; Uchida, S.
- Journal Title
  
  Biochem. J.
  
  Volume: 455 Issue: 3 Pages: 339-345
- DOI
  10.1042/bj20130597
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136013, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25670406
[Journal Article] Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms2013
- Author(s)
  Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 439(1) Issue: 1 Pages: 30-4
- DOI
  10.1016/j.bbrc.2013.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.2013
- Author(s)
  Wakabayashi M
- Journal Title
  
  Cell Rep.
  
  Volume: 28 Issue: 3 Pages: 858-868
- DOI
  10.1016/j.celrep.2013.02.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Effect of heterozygous deletion of WNK1 on the WNK-OSR1 / SPAK-NCC / NKCC1 / NKCC2 signal cascade in the kidney and blood vessels2012
- Author(s)
  Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 16(4) Pages: 530-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168
[Journal Article] A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo2012
- Author(s)
  Oi K
- Journal Title
  
  Biology Open
  
  Volume: Vol.1 Issue: 2 Pages: 120-127
- DOI
  10.1242/bio.2011048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK - OSR1/SPAK - NCC phosphorylation cascade in hyperinsulinemic db/db Mice2012
- Author(s)
  Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Hypertension
  
  Volume: 60(4) Pages: 981-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168
[Journal Article] Does a β2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney?2012
- Author(s)
  Uchida S
- Journal Title
  
  Nat. Med.
  
  Volume: 18 Issue: 9 Pages: 1324-1325
- DOI
  10.1038/nm.2809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.2012
- Author(s)
  Hossain Khan MZ
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 425 Issue: 2 Pages: 456-461
- DOI
  10.1016/j.bbrc.2012.07.124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone.2012
- Author(s)
  Susa K
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 427 Issue: 4 Pages: 743-747
- DOI
  10.1016/j.bbrc.2012.09.130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade2011
- Author(s)
  Chiga M
- Journal Title
  
  J. Cell Sci.
  
  Volume: Vol.124 Issue: 9 Pages: 1391-5
- DOI
  10.1242/jcs.084111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Regulation of WNK1 kinase by extracellular potassium2011
- Author(s)
  Naito S
- Journal Title
  
  Clin. Exp. Nephrol.
  
  Volume: Vol.15 Issue: 2 Pages: 195-202
- DOI
  10.1007/s10157-010-0378-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney2011
- Author(s)
  Sohara E
- Journal Title
  
  PLoS One
  
  Volume: Vol.6 Issue: 8 Pages: e24277-e24277
- DOI
  10.1371/journal.pone.0024277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice2010
- Author(s)
  Yang SS, Hsu YJ, Chiga M, Rai T, Sasaki S, Uchida S, Lin SH
- Journal Title
  
  Endocrinology
  
  Volume: 151(4) Issue: 4 Pages: 1829-36
- DOI
  10.1210/en.2009-0951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168
[Journal Article] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney2010
- Author(s)
  Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 393(4) Issue: 4 Pages: 844-8
- DOI
  10.1016/j.bbrc.2010.02.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168
[Journal Article] Dietarysalt regulates the phosphorylation ofOSR1/SPAK kinases and the sodiumchloride cotransporter throughaldosterone2008
- Author(s)
  Chiga M, Rai T, Yang SS, Ohta A,Takizawa T, Sasaki S, Uchida S
- Journal Title
  
  Kidney Int 74
  
  Pages: 1403-1409
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Barttin binds to the outerlateral surface of the ClC-K2 chloride channel2007
- Author(s)
  Tajima M, Hayama A, Rai T, Sasaki S,Uchida S
- Journal Title
  
  Biochem Biophys Res Commun 362(4)
  
  Pages: 858-64
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Molecular pathogenesis ofpseudohypoaldosteronism type II : generation and analysis of a Wnk4^<D561A/+> knockin mouse model2007
- Author(s)
  Yang SS, Morimoto T, Rai T, Chiga M,Sohara E, Ohno M, Uchida K, Lin SH,Moriguchi T, Shibuya H, Kondo Y, SasakiS, Uchida S
- Journal Title
  
  Cell Metab 5(5)
  
  Pages: 331-44
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Intracellular localization of ClCchloride channels and their ability toform hetero-oligomers2006
- Author(s)
  Suzuki T, Rai T, Hayama A, Sohara E,Suda S, Itoh T, Sasaki S, Uchida S
- Journal Title
  
  J Cell Physiol 206(3)
  
  Pages: 792-8
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Pathogenesis andtreatment of autosomal-dominantnephrogenic diabetes insipidus caused by an aquaporin 2 mutation.2006
- Author(s)
  Sohara E, Rai T, Yang SS, Uchida K,Nitta K, Horita S, Ohno M, Harada A,Sasaki S, Uchida S
- Journal Title
  
  Proc Natl Acad Sci U S A 103(38)
  
  Pages: 14217-22
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal2006
- Author(s)
  Rai T
- Journal Title
  
  Am J Physiol Cell Physiol 290
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Overexpression ofhuman WNK1 increases paracellularchloride permeability and phosphorylation of claudin-4 in MDCKII cells2006
- Author(s)
  Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun 349(2)
  
  Pages: 804-8
- Data Source
  KAKENHI-PROJECT-18590883
[Journal Article] Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.2004
- Author(s)
  Yamauchi K, Rai T, Uchida S, et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 101
  
  Pages: 4690-4694
- Data Source
  KAKENHI-PROJECT-14770548
[Journal Article] Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells.
- Author(s)
  Yang S, Rai T, Uchida S, et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. (in press)
- Data Source
  KAKENHI-PROJECT-14770548
[Journal Article] Identification of a novel water channel, AQP12, expressed in pancreatic acinar cells.
- Author(s)
  Itoh T, Rai T, Uchida S, et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. (in press)
- Data Source
  KAKENHI-PROJECT-14770548
[Presentation] AMP感知機構をバイパスしたAMPK活性化によるCKDの新規治療戦略の発見2023
- Author(s)
  柳智貴, 蘇原映誠, 菊池寛昭, 竹内恒, 須佐紘一郎, 藤木珠美, 森雄太郎, 安藤史顕, 萬代新太郎, 森崇寧, 本田真也, 鳥居暁, 清水重臣, 頼建光, 内田信一
- Organizer
  第６６回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 当院における高齢血液透析導入患者の予後2023
- Author(s)
  荒川春奈、阿部誠、頼建光、石光晃、藤乘嗣泰
- Organizer
  第68回日本透析医学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Alox15 knock-outマウスは、腎臓におけるPGD2の増加を介してCKDの腎障害及び線維化を改善する2021
- Author(s)
  高橋直宏, 蘇原映誠, 有田誠, 菊池寛昭, 安藤史顕, 須佐紘一郎, 萬代新太郎, 森崇寧, 頼建光, 内田信一
- Organizer
  第６４回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 尿細管基底膜の厚い二重化は、成人ネフロン癆の遺伝学的診断根拠となり得る2021
- Author(s)
  藤丸拓也, 蘇原映誠, 川西邦夫, 森崇寧, 千賀宗子, 萬代新太郎, 安藤史顕, 須佐紘一郎, 飯盛聡一郎, 内藤省太郎, 頼建光, 長田道夫, 内田信一
- Organizer
  第６４回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 遺伝性腎臓病が疑われた症例において嚢胞性腎疾患を除く約半数にCOL4A遺伝子群の希少変異を認めた2021
- Author(s)
  河本亮介, 森崇寧, 安藤史顕, 萬代新太郎, 須佐紘一郎, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第６４回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] バゾプレシンはPKA活性化を介してuromodulin尿中分泌を促進する2021
- Author(s)
  七松東, 森崇寧, 安藤史顕, 古荘泰佑, 萬代新太郎, 須佐紘一郎, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第６４回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] PKA活性化薬は白色脂肪のベージュ化を促進し、高脂肪食負荷マウスで体重増加を抑制する2021
- Author(s)
  藤木珠美, 安藤史顕, 萬代新太郎, 須佐紘一郎, 森崇寧, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第６４回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 腎生検にてネフロン癆が疑われた成人症例における臨床・病理所見と遺伝的背景の関係2020
- Author(s)
  藤丸拓也, 蘇原映誠, 森崇寧, 萬代新太郎, 千賀宗子, 菊池寛昭, 安藤史顕, 森雄太郎, 岡戸丈和, 頼建光, 川西邦夫, 内田信一
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] PKA活性化薬は高脂肪食負荷マウスにおいて熱産生を亢進し体重増加を抑制する2020
- Author(s)
  藤木珠美, 安藤史顕, 萬代新太郎, 磯部清志, 須佐紘一郎, 森崇寧, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Alox15 KO マウスはCKD の腎障害及び線維化に抵抗性を示す2020
- Author(s)
  高橋直宏、蘇原映誠、有田誠、菊池寛昭、安藤史顕、磯部清志、須佐紘一郎、萬代新太郎、森崇寧、頼建光、内田信一
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] PKA は hepsin の活性に影響し uromodulin の細胞外分泌を促進する2020
- Author(s)
  七松東, 森崇寧, 安藤史顕, 萬代新太郎, 磯部清志, 須佐紘一郎, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] TNFαは腎臓でのWNK1分解を抑制し慢性腎臓病の塩分感受性を亢進させる2020
- Author(s)
  古荘泰佑、蘇原映誠、萬代新太郎、菊池寛昭、高橋直宏、藤丸拓也、橋本博子、新井洋平、安藤史顕、銭谷慕子、森崇寧、須佐紘一郎、磯部清志、野村尚弘、岡戸丈和、頼建光、内田信一
- Organizer
  第30回バゾプレシン研究会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Gitelman 症候群と臨床診断された成人患者の遺伝的背景と変異陰性例における表現系の検討2020
- Author(s)
  森崇寧, 千賀宗子, 藤丸拓也, 萬代新太郎, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] AMPK activation bypassing AMP sensing mechanism is a novel therapeutic strategy for chronic kidney disease2020
- Author(s)
  Kikuchi H, Sohara E, Nomura N, Mori T, Minamishima YA, Takahashi N, Furusho T, Ando F, Isobe K, Susa K, Rai T, Uchida S
- Organizer
  第8回 Chronic Kidney Disease Frontier Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 12/15-Lipoxygenase Knockout Mice Exhibit a Resistance to Kidney Damage in CKD2019
- Author(s)
  Takahashi N, Kikuchi H, Arita M, Ando F, Mandai S, Isobe K, Susa K, Mori T, Nomura N, Rai T, Uchida S, Sohara E.
- Organizer
  American Society of Nephrology Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] TNFαは腎臓でのWNK1分解を抑制して塩分感受性を亢進させる2019
- Author(s)
  古荘泰佑、蘇原映誠、萬代新太郎、菊池寛昭、新井洋平、安藤史顕、銭谷慕子、森崇寧、須佐絋一郎、磯部清志、野村尚弘、岡戸丈和、頼建光、内田信一
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Derivatives of FMP-API-1/27 Robustly Activate AQP2 Water Channels Independently of Vasopressin2019
- Author(s)
  Ando F, Yui N, Mandai S, Isobe K, Mori T, Susa K, Nomura N, Sohara E, Rai T, Uchida S.
- Organizer
  American Society of Nephrology Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 骨折部位と死亡率の関連は透析患者と一般集団で異なる2019
- Author(s)
  萬代新太郎、佐藤英彦、飯盛聡一郎、内藤省太郎、田中春奈、安藤史顕、須佐紘一郎、磯部清志、森崇寧、野村尚弘、蘇原映誠、岡戸丈和、内田信一、伏見清秀、頼建光
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] ω3系脂肪酸合成酵素fat-1 トランスジェニックマウスは薬剤性CKDモデルに抵抗性である2019
- Author(s)
  高橋直宏、菊池寛昭、有田誠、古荘泰佑、安藤史顕、磯部清志、須佐紘一郎、森崇寧、野村尚弘、頼建光、内田信一、蘇原映誠
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] 低タンパク食はAMPKのAMP/ATP比感知障害改善を介して腎保護効果を発揮する2019
- Author(s)
  菊池寛昭、蘇原映誠、野村尚弘、森崇寧、頼建光、内田信一
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] トルバプタンはPERKのリン酸化を介してNrf2/HO-1を活性化する2019
- Author(s)
  藤木珠美、安藤史顕、磯部清志、須佐紘一郎、森崇寧、野村尚弘、蘇原映誠、頼建光、内田信一
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] PKA活性化薬の開発と先天性腎性尿崩症治療への応用2019
- Author(s)
  安藤史顕、磯部清志、森崇寧、須佐紘一郎、野村尚弘、蘇原映誠、頼　建光、内田　信一
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Tacrolimus Improved Symptoms of Type 4 Bartter Syndrome Model Mice2019
- Author(s)
  Matsuura Y, Nomura N, Shoda W, Sohara E, Rai Tatemitsu, Uchida S.
- Organizer
  American Society of Nephrology Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Tolvaptan and Bardoxolone Methyl Synergistically Activate the Nrf2/HO-1 Pathway2019
- Author(s)
  Fujiki T, Ando F, Mandai S, Isobe K, Susa K, Mori T, Nomura N, Sohara E, Rai T, Uchida S.
- Organizer
  American Society of Nephrology Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] Renal TNFα Activates WNK Phosphorylation Cascade and Contributes to Salt-Sensitive Hypertension in CKD2019
- Author(s)
  Furusho T, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Mori T, Susa K, Isobe K, Nomura N, Okado T, Rai T, Yamamoto K, Uchida S, Sohara E.
- Organizer
  American Society of Nephrology Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] NCX1を介したNCCの脱リン酸化と尿中カリウム排泄機構の解明2019
- Author(s)
  正田若菜、野村尚弘、安藤史顕、田頭秀章、岩本隆宏、太田哲人、磯部清志、森崇寧、須佐紘一郎、蘇原映誠、頼建光、内田信一
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03556
[Presentation] WNK1-OSR1/SPAK-NCCシグナルの亢進が慢性腎臓病モデルマウスの塩分感受性高血圧に関与する2018
- Author(s)
  古荘泰佑、蘇原映誠、萬代新太郎、菊池寛昭、銭谷慕子、野村尚弘、森崇寧、頼建光、内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] 高カリウム負荷によるナトリウム-クロライド共輸送体の脱リン酸化機構の解明2018
- Author(s)
  正田若菜、野村尚弘、安藤史顕、磯部清志、森崇寧、蘇原映誠、頼建光、内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK1-SPAK-NCC Signaling Cascade Is Involved in Salt Sensitive Hypertension Induced by Aristolochic Acid Nephropathy2018
- Author(s)
  Furusho T, Uchida S, Sohara E, Mandai S, Kikuchi H, Ando F, Zeniya M, Mori T, Nomura N, Rai T
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] AKAPs-PKA結合阻害薬はバゾプレシン非依存性に強力にAQP2水チャネルを活性化する2018
- Author(s)
  安藤史顕、森修一、油井直史、森本哲司、野村尚弘、蘇原映誠、頼建光、佐々木成、根東義明、影近弘之、内田信一
- Organizer
  第9回分子腎臓フォーラム
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK1キナーゼはFOXO4の細胞核内局在，転写活性を調節し，骨格筋肥大を制御する2018
- Author(s)
  萬代新太郎、森崇寧、野村尚弘、古荘泰佑、新井洋平、菊池寛昭、佐々木絵美、蘇原映誠、頼建光、内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Metformin Has Natriuretic Effects Through Reduction of the Sodium-Chloride Cotransporter Phosphorylation2018
- Author(s)
  Hashimoto H, Okado T, Rai T, Uchida S, Sohara E, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, Fujimaru T, Ando F, Mori T
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK1はマクロファージにおいてLPS誘導性サイトカイン産生を抑制する2018
- Author(s)
  新井洋平、蘇原映誠、浅野謙一、田中正人、頼建光、内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK1 Regulates Skeletal Muscle Hypertrophy by Modulating Phosphorylation, Nuclear Localization, and Transcriptional Activity of FoxO42018
- Author(s)
  Mandai S, Uchida S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] AKAPs-PKA Disruptors Robustly Increase AQP2 Activity Independently of Vasopressin2018
- Author(s)
  Ando F, Yui N, Nomura N, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] FMP-API-1はバゾプレシンに匹敵するAQP2水チャネル活性化作用を持つ―新規腎性尿崩症治療薬の開発―2018
- Author(s)
  安藤史顕、油井直史、森本哲司、野村尚弘、蘇原映誠、頼建光、佐々木成、根東義明、内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] メトホルミンは腎NCCのリン酸化を低下させ塩分排泄を促進する2018
- Author(s)
  橋本博子、蘇原映誠、野村尚宏、正田若菜、磯部清志、菊池寛昭、安藤史顕、森崇寧、頼建光、内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Molecular Mechanism of High-Potassium Induced Na-Cl Cotransporter Dephosphorylation2018
- Author(s)
  Shoda W, Nomura N, Ando F, Isobe K, Mori T, Sohara E, Rai T, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Generation and analysis of KLHL2 knockout mice2017
- Author(s)
  Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] 塩は近位尿細管細胞においてJAK/STAT系を介してIFNgamma関連ケモカインを抑制する2017
- Author(s)
  新井洋平、蘇原映誠、高橋大栄、浅野謙一、田中正人、小田真由美、洪繁、洪実、萬代新太郎、野村尚弘、頼建光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK1はマクロファージにおけるLPS誘導性サイトカイン産生を抑制する2017
- Author(s)
  新井洋平、蘇原映誠、浅野謙一、田中正人、頼建光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] 変異CUL3によるPHAIIの発症にはKLHL3の発現低下が関与する2017
- Author(s)
  吉田紗矢香、蘇原映誠、荒木雄也、笠木祐里、佐々木絵美、須佐紘一郎、森崇寧、井上佑一、磯部清志、頼建光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] ループ利尿薬はマウス骨格筋細胞分化および運動による筋肥大効果を抑制する2017
- Author(s)
  萬代新太郎、古川晋、小高愛未、畑裕、森崇寧、野村尚弘、蘇原映誠、頼建光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK4 deletion inhibits adipogenesis in vitro and in vivo2017
- Author(s)
  Takahashi D, Mori T, Sohara E, Miyako Tanaka M, Inoue Y, Nomura N, Chiga M, Zeniya M, Suganami T, Rai T, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] KLHL2は腎臓でWNK4蛋白の分解を行う2017
- Author(s)
  笠木祐里、蘇原映誠、相田知海、高橋大栄、西田秀範、野村尚弘、銭谷慕子、森崇寧、佐々木絵美、安藤史顕、頼建光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK4は脂肪細胞分化の制御因子である2017
- Author(s)
  高橋大栄、森崇寧、蘇原映誠、田中都、千賀宗子、井上佑一、野村尚弘、銭谷慕子、越智広樹、竹田秀、菅波孝祥、頼建光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] WNK4は脂肪細胞分化の制御因子である2017
- Author(s)
  高橋大栄、森崇寧、蘇原映誠、田中都、千賀宗子、井上佑一、野村尚弘、銭谷慕子、越智広樹、竹田秀、菅波孝洋、頼建光、内田信一
- Organizer
  第8回分子腎臓フォーラム
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] A high salt diet suppressed CXCL9 and CXCL10 in proximal tubules through the IFNγ-JAK1-STAT1 signaling pathway2017
- Author(s)
  Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SB, Ko MS, Mandai S, Nomura N, Rai T, Uchida S, Sohara E
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Decreased protein expression of KLHL3 is involved in the pathogenesis of PHAII caused by CUL3 mutation in vivo2017
- Author(s)
  Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Rai T, Uchida S, Sohara E
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] The pseudohypoaldosteronism type II-causing mutant Cul3 protein forms dimer with KLHL3 and inhibits the degradation of WNK4 with a dominant-negative effect.2016
- Author(s)
  Araki Y, Tatemitsu Rai T, Sohara E, Mori T, Inoue Y, Mori Y, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2016
- Place of Presentation
  Chicago USA
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] 変異KLHL3による偽性低アルドステロン症II型の発症にはWNK4が必要である2016
- Author(s)
  須佐紘一郎、蘇原　映誠、高橋　大栄1、頼　建光、内田　信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター　　神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Generation of p62/SQSTM1 (p62) KO cell lines using CRISPR/Cas9 -The role of p62 on WNK1 regulation by changes of extracellular potassium concentration-.2016
- Author(s)
  Mori Y, Mandai S, Mori T, Sohara E, Rai T, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2016
- Place of Presentation
  Chicago USA
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] CaMK1gはWNK4 S1190をリン酸化する2016
- Author(s)
  新井洋平、蘇原　映誠、高橋　大栄、小田　真由美、洪　繁、洪　実、頼　建光、内田　信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター　神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] CRISPR/Cas9システムを用いたp62ノックアウト細胞の作成とその解析-カリウムによるWNK1制御におけるp62の役割-2016
- Author(s)
  森雄太郎、小川　祥、萬代　新太郎、森　崇寧、蘇原　映誠、頼　建光、内田　信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター　神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] 血管平滑筋のカリウムによるKLHL2を介したWNK3シグナル制御機構解明2016
- Author(s)
  Wang　Yuanlong、蘇原　映誠、銭谷　慕子、森　雄太郎、内藤　省太郎、頼　建光、内田　信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター　神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Drug repositioning screening for the discovery of inhibitors of Keap1-Nrf2 interaction using fluorescent correlation spectroscopy.2016
- Author(s)
  Yoshizaki Y, Sohara E, Mori T, Kikuchi E, Takahashi D, Zeniya M, Araki Y, Mori Y, Ando F, Nomura N, Rai T, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2016
- Place of Presentation
  Chicago USA
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] KLHL3ノックアウトマウスの作製と解析2016
- Author(s)
  佐々木絵美、蘇原　映誠、須佐　紘一郎、森　崇寧、磯部　清志、荒木　雄也、井上　佑一、頼　建光、内田　信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター　神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] CRISPR/Cas9システムを用いた高血圧関連遺伝子多型STK39 rs3754777ノックイン細胞の樹立と解析2016
- Author(s)
  萬代新太郎、森　崇寧、蘇原　映誠、頼　建光、内田　信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜会議センター　神奈川県横浜市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Generation and Analysis of KLHL3 Knockout Mice.2016
- Author(s)
  Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Rai T, Uchida S, Sohara E.
- Organizer
  American Society of Nephrology Kidney Week 2016
- Place of Presentation
  Chicago USA
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09642
[Presentation] Impaired KHLH3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases - NaCl cotransporter (NCC) signaling and causes hypertension2013
- Author(s)
  Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Impaired KHLH3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases-NaCl cotransporter (NCC) signaling and causes hypertension2013
- Author(s)
  Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] Clinical significance of urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement by newly developed enzyme-linked immunosorbent assays2013
- Author(s)
  Isobe K, Mori T, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Analyses of KHLH3 mutants that cause Pseudohypoaldosteronism type II2013
- Author(s)
  Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] Impaired KHLH3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases-NaCl cotransporter (NCC) signaling and causes hypertension2013
- Author(s)
  Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Chemical library screening for WNK signaling inhibitors by using fluorescent correlation spectroscopy2013
- Author(s)
  Mori T, Kikuchi E, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] KHLH2 interacts with and ubiquitinates WNK4 kinases2013
- Author(s)
  Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Rai T, Sohara E, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] Low salt intake decreased transcription and protein level of KLHL3 in mouse kidney2013
- Author(s)
  Susa K, Sohara E, Zeniya M, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Chemical library screening for WNK signaling inhibitors by using fluorescent correlation spectroscopy2013
- Author(s)
  Mori T, Kikuchi E, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] WNK3 regulates blood pressure through the regulation of vascular OSR1 / SPAK-NKCC1 phosphorylation cascade2013
- Author(s)
  Zeniya M, Sohara E, Oi K, Chiga M, Susa K, Mori T, Takahashi D, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] WNK3 regulates blood pressure through the regulation of vascular OSR1/SPAK-NKCC1 phosphorylation cascade2013
- Author(s)
  Zeniya M, Sohara E, Oi K, Chiga M, Susa K, Mori T, Takahashi D, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Analyses of KHLH3 mutants that cause Pseudohypoaldosteronism type II2013
- Author(s)
  Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] WNK3 regulates blood pressure through the regulation of vascular OSR1/SPAK-NKCC1 phosphorylation cascade2013
- Author(s)
  Zeniya M, Sohara E, Oi K, Chiga M, Susa K, Mori T, Takahashi D, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] KHLH2 interacts with and ubiquitinates WNK4 kinases2013
- Author(s)
  Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Rai T, Sohara E, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2013
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Development of sandwich enzyme linked immunosorbent assay for measurement of urinary total and phosphorylated Na-Cl cotransporter protein2012
- Author(s)
  Isobe K, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Generation and analysis of WT-WNK4 transgenic mice reveal the physiological role of WNK42012
- Author(s)
  Mori T, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] WNK4 - OSR1/SPAK - NCC signal cascade has circadian rhythm dependent on aldosterone2012
- Author(s)
  Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Dietary salt intake and angiotensin II regulates WNK - SPAK - NKCC1 phosphorylation cascade in mouse aorta2012
- Author(s)
  Zeniya M, Sohara E, Oi K, Chiga M, Susa K, Mori T, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination2012
- Author(s)
  Kahn MZH, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Chemical library screening for direct SPAK inhibitors by a newly devoloped ELISA2012
- Author(s)
  Kikuchi E, Mori T, Isobe K, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2012
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Development of new systems to measure total and phosphorylated Na-Cl cotransporter (NCC) protein in human urine2011
- Author(s)
  Isobe K, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney2011
- Author(s)
  Sohara E, Rai T, Yang SS, Ohta A, Lin SH, Vandewalle A, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] WNK - OSR1/SPAK - SLC12A phosphorylation cascade in the WNK1 (+/-) mice2011
- Author(s)
  Susa K, Sohara E, Rai T, Kita S, Iwamoto T, Alessi D, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia, U.S.A
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Urinary excretion of Na-Cl cotransporter in exosomes is increased by high salt diet as well as low salt diet2011
- Author(s)
  Kahn MZH, Sohara E, Ohta A, Naito S, Chiga M, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Increased Na-Cl cotransporter phosphorylation in hyperinsulinemic db/db mice is regulated by insulin/PI3K pathway2011
- Author(s)
  Nishida H, Sohara E, Alessi D, Nomura N, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia, U.S.A
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Acute Insulin Stimulation Induces Phosphorylation of the Na-Cl Cotransporter in Cultured Distal mpkDCT Cells and Mouse Kidney2011
- Author(s)
  Rai T
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] Increased protein abundance of the mutant WNK4 may be a cause of the increased WNK4 kinase activity in the mouse model of pseudohypoaldosteronism type II(PHA II).2011
- Author(s)
  Wakabayashi M, Naito S, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2011
- Place of Presentation
  Philadelphia, U.S.A.
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] 偽性低アルドステロン症II型モデルマウスにおけるNCCのリン酸化充進はOSR1とSPAKキナーゼの活性に依存する2010
- Author(s)
  頼建光
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22390168
[Presentation] WNK1 Activity to OSR1 in COS Cells IsRegulated Not by Hypotonicity but byLow Chloride2008
- Author(s)
  Shotaro Naito, Tatemitsu Rai, 他5名
- Organizer
  Renal Week 2008
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] 低浸透圧ストレスはOSR1/SPAKを持続的にリン酸化する2008
- Author(s)
  内藤省太郎, 頼建光, 他4名
- Organizer
  第51回日本腎臓学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] Targeted Disruption of the Wnk4 GeneReduced the Phosphorylation ofOSR/SPAK and Na-Cl Cotransporter in Mice2008
- Author(s)
  Akihito Ohta, Tatemitsu Rai, 他6名
- Organizer
  Renal Week 2008
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] Na-Cl共輸送体(NCC)のリン酸化は WNK4-OSR1/SPAK-NCCリン酸化刺激伝達系を介し経口NaCl摂取量により制御される2008
- Author(s)
  千賀宗子, 頼建光, 他5名
- Organizer
  第51回日本腎臓学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] WNK4ノックアウトマウス、作製と解析2008
- Author(s)
  太田哲人, 頼建光, 他6名
- Organizer
  第14回分子腎臓研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] Generation andanalysis of Wnk4D561A/+ knock-in mice2007
- Author(s)
  Yang S, Rai T, 他11名
- Organizer
  ISN-Nature Genetics ForefrontsSymposium on Nephrogenetics : fromDevelopment to Physiology
- Place of Presentation
  Danvers USA
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] Molecularpathogenesis of pseudohypoaldosteronism tupe II : generation and analysis of a Wnk4D561A/+knock-in mouse model2007
- Author(s)
  Yang S, Rai T, 他11名
- Organizer
  第50回日本腎臓学会学術総会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] Molecularpathogenesis ofpseudohypoaldosteronism type II : analysis of a Wnk4D561A/+ knock-in mice2007
- Author(s)
  Rai T, 他12名
- Organizer
  第13回分子腎臓研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] WNK1発現MDCKII細胞におけるparacellularのCl透過性とclaudin4のに関する検討2006
- Author(s)
  太田哲人,頼建光, 他3名
- Organizer
  第12回分子腎臓研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] WNK1遺伝子の強発現により細胞間のchloride透過性は亢進し、claudin4はリン酸化が増加する2006
- Author(s)
  太田哲人, 頼建光, 他3名
- Organizer
  第49回日本腎臓学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590883
[Presentation] Impaired degradation of WNK1 and WNK4 kinases causes PHAII in Mutant KLHL3 knock-in mice
- Author(s)
  Sohara E, Susa K, Rai T, Zeniya M, Mori Y, Sasaki S, Uchida S
- Organizer
  The 14th Asian Pacific Congress of Nephrology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] KLHL2 Mediates Angiotensin II-WNK3 Signaling Involved in the Regulation of Vascular Tonus.
- Author(s)
  Zeniya M, Takahashi D, Mori Y, Mori T, Ando F, Nomura N, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2014
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] p62-Mediated Selective Autophagy Is Involved in KLHL3-Dependent WNK4 Degradation
- Author(s)
  Mori Y, Wakabayashi M, Takayasu Mori T, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2014
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] Phosphorylation of KLHL3 in the Kelch-Repeat Regulates Its Binding Ability to WNK4
- Author(s)
  Yoshizaki Y, Sohara E, Mori T, Mori Y, Wakabayashi M, Rai T, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2014
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-24659412
[Presentation] Molecular Pathogenesis of PHAII in KLHL3R528H/+ Knock-In Mice
- Author(s)
  Susa K, Sohara E, Tatemitsu Rai T, Zeniya M, Mori Y, Takayasu Mori T, Chiga M, Takahashi D, Inoue Y, Isobe K, Takeda N, Sasaki S, Uchida S
- Organizer
  American Society of Nephrology Kidney Week 2014
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-24659412

1. 野田裕美 (30372436)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 田村由馬 (60727585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 橋本弘史 (10454935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 安隆則 (40265278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 美津島隆 (80279348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 亀川亜希子 (50867554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐々木成 (60170677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
9. 川西邦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 森崇寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 藤井晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 影近弘之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 藤丸拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 越智広樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 安藤史顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田頭秀章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Rai Tatemitsu 頼 建光

RAI TATEMITSU 頼 建光

RAI Tatemitsu 頼 建光

頼 建光 ライ タテミツ

Research Projects

Research Products

Co-Researchers

Novel therapies for chemotherapy-induced fluid disorders via targeting water channelsPrincipal Investigator

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Elucidating the mechanism of exercise-drug combination in preventing severe diabetic nephropathy

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Discovery of direct water channel inhibitors using aquaporin nanodisc technology

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Elucidation of the molecular pathogenesis of sarcopenia and development of novel therapeutic strategiesPrincipal Investigator

Principal Investigator

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Review Section

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Novel functions and regulation of WNK signaling cascadePrincipal Investigator

Principal Investigator

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Development of novel hypertensive drugs based on inhibition of protein interactionPrincipal Investigator

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Analysis of WNK-NCC signaling cascade, a novel blood pressure controlling system, in the kidneyPrincipal Investigator

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Analysis of WNK kinases and the molecular pathophysiology of hypertensionPrincipal Investigator

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腎臓における時間空間的に制御可能な臓器細胞特異的遺伝子変異導入システムの開発Principal Investigator

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[Journal Article] A case of unexpected diagnosis of fibronectin glomerulopathy with histological features of membranoproliferative glomerulonephritis2024

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[Journal Article] Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study2023

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[Journal Article] Crescentic glomerulonephritis associated with syphilis: a case report and review of the?literature2023

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[Journal Article] National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 20192023

Rai Tatemitsu 頼建光

RAI TATEMITSU 頼建光

RAI Tatemitsu 頼建光

頼建光ライタテミツ