NAGAI Hiroshi 永井宏

Researcher Number	80335447
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2018: 神戸大学, 医学研究科, 准教授 2010 – 2015: 神戸大学, 医学部附属病院, 講師 2005: 神戸大学, 大学院医学研究科, 助手 2001 – 2004: 神戸大学, 大学院・医学系研究科, 助手
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology / Urology
Keywords	Principal Investigator 乾癬 / 悪性黒色腫 / IL-27 / サイトカイン / インターロイキン23 / メラノーマ / IL-12 / 抗CD25抗体 Except Principal Investigator IL-18 / 表皮角化細胞 … More / 活性酸素 / 小胞体ストレス / UVB / ロドデノール / グルタチオン / 色素細胞 / アポトーシス / 酸化ストレス / N-アセチルシステイン / 白斑 / ERストレス / 美白剤 / 紫外線 / メラノサイト / renal cell carcinoma / Immune gene therapy / 腎細胞癌 / 遺伝子治療 Less

Role of oxidative stress in the cytotoxicity caused by skin whitening agents
- Principal Investigator
  
  Nishigori Chikako
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasisPrincipal Investigator
- Principal Investigator
  
  NAGAI HIROSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
Basic studies on therapeutic utilities ofIL-27 for malignant melanoma, psoriasis and alopecia areata.Principal Investigator
- Principal Investigator
  
  NAGAI Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
IL-23によるマウスB16F10メラノーマに対する免疫遺伝子療法Principal Investigator
- Principal Investigator
  
  永井宏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
IL-12産生メラノーマ担癌マウスにおけるCD25陽性抑制性T細胞の役割Principal Investigator
- Principal Investigator
  
  永井宏
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
Secreted type of modified interleukin-18 gene transduced into mouse renal cell carcinoma cells induces systemic tumor immunity
- Principal Investigator
  
  HARA Isao
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kobe University Graduate School of Medicine

All 2018 2016 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 皮膚科臨床アセット 112012
- Author(s)
  永井宏
- Publisher
  メラノーマに伴う白斑の病態・診断・鑑別診断
- Data Source
  KAKENHI-PROJECT-22591220
[Book] 皮膚科臨床アセット2012
- Author(s)
  永井宏
- Publisher
  Sutton 白斑の病態・診断・鑑別診断
- Data Source
  KAKENHI-PROJECT-22591220
[Journal Article] 4-(4-Hydroxyphenyl)-2-butanol (rhododendrol)-induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress2018
- Author(s)
  Goto Noriko、Tsujimoto Mariko、Nagai Hiroshi、Masaki Taro、Ito Shosuke、Wakamatsu Kazumasa、Nishigori Chikako
- Journal Title
  
  Experimental Dermatology
  
  Volume: Epub Issue: 7 Pages: 754-762
- DOI
  10.1111/exd.13555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10156
[Journal Article] Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist.2014
- Author(s)
  Fujiwara, S., Nagai, H., Shimoura, N., Oniki, S., Yoshimoto, T., and Nishigori, C.
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 134 Issue: 7 Pages: 1884-1892
- DOI
  10.1038/jid.2014.42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24659595, KAKENHI-PUBLICLY-25118727, KAKENHI-PROJECT-25461692
[Journal Article] Interleukin(IL)-17 versus IL-27: Opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes2012
- Author(s)
  S. Fujiwara, H. Nagai, S. Oniki, T. Yoshimoto, and C. Nishigori
- Journal Title
  
  Exp. Dermatol
  
  Volume: 21 Issue: 1 Pages: 70-72
- DOI
  10.1111/j.1600-0625.2011.01384.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591220, KAKENHI-PROJECT-24370058
[Journal Article] IL-17 versus IL-27 : Opposite effects on TNF-α-induced chemokine production in human keratinocytes2012
- Author(s)
  Fujiwara S, Nagai H, Oniki S, Yoshimoto T, Nishigori C
- Journal Title
  
  Experimental Dermatology
  
  Volume: 21 Pages: 70-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591220
[Journal Article] IL-23 gene therapy for mouse bladder tumor cell lines2011
- Author(s)
  T. Kuramoto, R Fujii, H. Nagai, M.L.Belladonna, T. Yoshimoto, Y. Kohjimoto, T. Inagaki, and I. Hara.
- Journal Title
  
  BJU int
  
  Volume: 108 Issue: 6 Pages: 914-921
- DOI
  10.1111/j.1464-410x.2010.10025.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591220
[Journal Article] Antimelanoma immunotherapy: clinical and preclinical applications of IL-12 family members2010
- Author(s)
  H. Nagai, S. Oniki, S. Fujiwara, T. Yoshimoto, and C. Nishigori
- Journal Title
  
  Immunotherapy.
  
  Volume: 2 Issue: 5 Pages: 697-709
- DOI
  10.2217/imt.10.46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591220
[Presentation] N-acetylcysteine (NAC)は紫外線によるロドデノールの色素細胞障害性増強効果を軽減する2016
- Author(s)
  後藤典子, 辻本昌理子, 永井宏, 正木太朗, 伊藤祥輔, 若松一雅, 錦織千佳子
- Organizer
  第27回日本色素細胞学会年次学術大会
- Place of Presentation
  岐阜大学サテライトキャンパス（岐阜県岐阜市）
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-16K10156
[Presentation] メラノーマ組織内CD4+T細胞除去による抗腫瘍免疫反応機序の解析2013
- Author(s)
  永井　宏、藤原　進、下浦典子、善本隆之、錦織千佳子
- Organizer
  第２５回日本色素細胞学会学術大会
- Place of Presentation
  大阪大学銀杏会館
- Data Source
  KAKENHI-PROJECT-25461692
[Presentation] Interleukin-17 and interleukin-27 exert opposite effects on tumor necrosis factor-alpha -mediated psoriasis related chemokine production in human keratinocytes2012
- Author(s)
  Susumu Fujiwara, Hiroshi Nagai, Shuntaro Oniki, Takayuki Yoshimoto, and Chikako Nishigori
- Organizer
  2ndEasetern Asia Dermatology Congress
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-22591220
[Presentation] IL-17 versus IL-27 : opposite effects on TNF-α-induced chemokine production in human keratinocytes2011
- Author(s)
  Fujiwara S, Nagai H, Oniki S, Yoshimoto T, Nishigori C
- Organizer
  日本研究皮膚科学会第36回年次学術大会・総会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22591220
[Presentation] IL-17 versus IL-27: Opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes2011
- Author(s)
  Susumu Fujiwara, Hiroshi Nagai, Shuntaro Oniki, Takayuki Yoshimoto, and Chikako Nishigori
- Organizer
  日本研究皮膚科学会第36回年次学術大会・総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591220
[Presentation] Intratumoral CD4+ cell depletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist
- Author(s)
  Susumu Fujiwara, Hiroshi Nagai, Noriko Shimoura, Shuntaro Oniki, Takayuki Yoshimoto,Chikako Nishigori
- Organizer
  日本研究皮膚科学会　第39回年次学術大会・総会
- Place of Presentation
  大阪
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25461692

1. YOSHIMOTO Takayuki (80202406)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. HARA Isao (10263378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Nishigori Chikako (50198454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

NAGAI Hiroshi 永井 宏

Research Projects

Research Products

Co-Researchers

Role of oxidative stress in the cytotoxicity caused by skin whitening agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic studies on therapeutic utilities ofIL-27 for malignant melanoma, psoriasis and alopecia areata.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-23によるマウスB16F10メラノーマに対する免疫遺伝子療法Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-12産生メラノーマ担癌マウスにおけるCD25陽性抑制性T細胞の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Secreted type of modified interleukin-18 gene transduced into mouse renal cell carcinoma cells induces systemic tumor immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 皮膚科臨床アセット 112012

Author(s)

Publisher

Data Source

[Book] 皮膚科臨床アセット2012

Author(s)

Publisher

Data Source

[Journal Article] 4-(4-Hydroxyphenyl)-2-butanol (rhododendrol)-induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin(IL)-17 versus IL-27: Opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-17 versus IL-27 : Opposite effects on TNF-α-induced chemokine production in human keratinocytes2012

Author(s)

Journal Title

Data Source

[Journal Article] IL-23 gene therapy for mouse bladder tumor cell lines2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antimelanoma immunotherapy: clinical and preclinical applications of IL-12 family members2010

Author(s)

Journal Title

DOI

Data Source

[Presentation] N-acetylcysteine (NAC)は紫外線によるロドデノールの色素細胞障害性増強効果を軽減する2016

Author(s)

Organizer

NAGAI Hiroshi 永井宏