TSUNEYOSHI Naoko 常吉直子

Researcher Number	80336114
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2012: 佐賀大学, 医学部, 研究員 2010 – 2012: 佐賀大学, 医学部, 客員研究員 2007: Saga University, 医学部, 客員研究員 2003 – 2006: 佐賀大学, 医学部, 助手 2002: 佐賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Laboratory medicine Except Principal Investigator Hematology / Immunology
Keywords	Principal Investigator プロテインC / レセプター / 血管内皮 / 抗体 / ELISA / エンドトキシン / 自然免疫 / 感染症 / 血管病変 / 乳癌 … More Except Principal Investigator … More 血管内皮 / モノクローナル抗体 / PAR / LPS / MD-2 / inflammation / receptor / endothelial cell / protein C / 受容体 / トロンビン / 炎症 / レセプター / プロテインC / pCAGG-S1 vector / epitope / NF κ B reporter gene / E coli expression / fusion protein / pET32 vector / pCAG-S1ベクター / pCAGG-S1ベクター / エピトープ / NFκBレポーター遺伝子 / 大腸菌発現系 / 融合蛋白 / pET32ベクター / blood coagulation / monoclonal antibody / endothelial / thrombosis / 血液凝固 / 血栓 / 抗体 / アゴニスト / 敗血症 / TLR / TLR4 / ストレスシグナル / 粗面小胞体 / 血液免疫学 Less

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
MD-2血中濃度測定法の開発Principal Investigator
- Principal Investigator
  
  常吉直子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Saga University
Structural and Functional Analysis of the MD-2 protein
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Regulation mechanism for inflammation mediated by endothelial cell protein C receptor
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
可溶型血管内皮プロテインCレセプター測定系による血管病変の解析Principal Investigator
- Principal Investigator
  
  常吉直子
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Saga University
Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodies
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
  佐賀医科大学
血管内皮プロテインCレセプターの発現を指標とした乳癌スクリーニング法の開発Principal Investigator
- Principal Investigator
  
  常吉直子
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  佐賀医科大学

All 2013 2011 2010 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2013
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume: 190(1) Pages: 195-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] nhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013
- Author(s)
  Nurlaely MR, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Yanagibashi T, Nagai Y, Takatsu K, Ohta S, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume: 25(2) Pages: 117-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 271-80
- NAID
  10027392279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.2007
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology 244(1)
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790371
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.2007
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology 244(1)
  
  Pages: 57-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591001
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.2006
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology 244(1)
  
  Pages: 57-64
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590439
[Journal Article] The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  J Immunol. 174(1)
  
  Pages: 340-344
- Data Source
  KAKENHI-PROJECT-17590439
[Journal Article] Preparation and characterization of monoclonal antibodies to thrombomodulin.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Hybridoma 24(4)
  
  Pages: 189-196
- Data Source
  KAKENHI-PROJECT-17590439
[Journal Article] The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  J Immunol. 174
  
  Pages: 340-344
- Data Source
  KAKENHI-PROJECT-16790316
[Journal Article] Preparation and characterization of monoclonal antibodies to thrombomodulin.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Hybridoma 24(4)
  
  Pages: 189-196
- Data Source
  KAKENHI-PROJECT-16790316
[Journal Article] The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  J Immunol. 174
  
  Pages: 340-344
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591011
[Journal Article] The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  J Immunol. 174(1)
  
  Pages: 340-344
- Data Source
  KAKENHI-PROJECT-17591001
[Journal Article] Preparation and characterization of monoclonal antibodies to thrombomodulin.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Hybridoma 24(4)
  
  Pages: 189-196
- Data Source
  KAKENHI-PROJECT-17591001
[Journal Article] プロテインCとその受容体の機能2005
- Author(s)
  常吉直子
- Journal Title
  
  血管医学 6(3)
  
  Pages: 245-252
- Data Source
  KAKENHI-PROJECT-16790316
[Journal Article] The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.2005
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  J Immunol. 174(1)
  
  Pages: 340-344
- Data Source
  KAKENHI-PROJECT-16790316
[Journal Article] プロテインCとその受容体の機能2005
- Author(s)
  常吉直子
- Journal Title
  
  血管医学 6(3)
  
  Pages: 245-252
- Data Source
  KAKENHI-PROJECT-17591001
[Journal Article] MD-2のLPS結合におけるヒトとマウスの違い2004
- Author(s)
  常吉直子
- Journal Title
  
  日本免疫学会総会誌 34
  
  Pages: 48-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591011
[Journal Article] MAb PS7 against human protein S2004
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Hybridoma and Hybridomics 23
  
  Pages: 389-389
- Data Source
  KAKENHI-PROJECT-16790316
[Journal Article] MD-2のLPS結合におけるヒトとマウスの違い2004
- Author(s)
  常吉直子
- Journal Title
  
  日本免疫学会総会誌 34
  
  Pages: 48-48
- Data Source
  KAKENHI-PROJECT-16790316
[Journal Article] Expression of MD-1 protein in CHO cells.2003
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  生化学 75
  
  Pages: 873-873
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591011
[Journal Article] Expression of MD-1 protein in CHO cells.2003
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Seikagaku 75
  
  Pages: 873-873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591011
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology (in press)
- Data Source
  KAKENHI-PROJECT-17590439
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591001
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology (in press)
- Data Source
  KAKENHI-PROJECT-18790371
[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction
- Author(s)
  Tsuneyoshi N
- Journal Title
  
  Cellular Immunology in press
- Data Source
  KAKENHI-PROJECT-17591001
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody.2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Lipopolysaccharidebindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064

1. FUKUDOME Kenji (50284625)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. KIMOTO Masao (40153225)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. WATANABE Keiichi (40191754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MOTOSHIMA Hiroyuki (20312275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUNEYOSHI Naoko 常吉 直子

Research Projects

Research Products

Co-Researchers

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MD-2血中濃度測定法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and Functional Analysis of the MD-2 protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation mechanism for inflammation mediated by endothelial cell protein C receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

可溶型血管内皮プロテインCレセプター測定系による血管病変の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管内皮プロテインCレセプターの発現を指標とした乳癌スクリーニング法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2013

Author(s)

Journal Title

Data Source

[Journal Article] nhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013

Author(s)

Journal Title

Data Source

[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.2007

Author(s)

Journal Title

Data Source

[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomelization of TLR4 required for signal transduction.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.2005

Author(s)

Journal Title

Data Source

[Journal Article] Preparation and characterization of monoclonal antibodies to thrombomodulin.2005

Author(s)

Journal Title

TSUNEYOSHI Naoko 常吉直子