Ishihara Keiichi 石原慶一

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ISHIHARA Keiichi 石原慶一

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Researcher Number	80340446
Other IDs
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 京都薬科大学, 薬学部, 准教授 2018: 京都薬科大学, 薬学部, 講師 2013 – 2016: 京都薬科大学, 薬学部, 講師 2010 – 2011: 京都薬科大学, 薬学部, 講師 2009: The Institute of Physical and Chemical Research, 薬学部, 助教 2008: The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員 2001 – 2004: 京都薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Complex systems / Basic Section 49030:Experimental pathology-related / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Pharmacology in pharmacy / Neurology / Neurology
Keywords	Principal Investigator ダウン症候群 / マウスモデル / 脳発達 / 炎症 / モデルマウス / 責任遺伝子 / 銅 / 知的障害 / 生命金属 / ミクログリア … More / 炎症性細胞 / 原因遺伝子 / 炎症細胞 / ダウン症 / 神経伝達物質 / 認知機能 / 初期エンドソーム / 記憶学習障害 / 炎症関連遺伝子 / 生体必須微量元素 / 脳 / 発達遅滞 / 血管形成 / 血管 / 脳マクロファージ / 網羅的遺伝子発現解析 / 神経新生 / 記憶学習 / マイクロアレイ解析 / プロテオミクス解析 / DNAマイクロアレイ / 胎仔脳 / オミクス解析 / 酸化ストレス … More Except Principal Investigator SBMA / Hsp70 / Hsp105 / NSAIDs / Apoptosis / Polygultamine disease / Molecular chaperone / アポトーシス / Hsp40 / ポリグルタミン病 / 分子シャペロン / Smad2/3 / 移植 / 造血幹細胞 / TGF-β1 / 線条体 / ヒト人工多能性幹細胞 / 多様性 / 貪食 / イメージング / 化合物 / 生薬成分 / 病態 / 老化 / 脳内免疫環境 / ヒトiPS細胞 / ホットスポット / 疾患関連ミクログリア / iPS細胞 / 神経保護 / 神経細胞死 / アミロイドβ / オルガノイド / 脳免疫 / ミクログリア / アルツハイマー病 / 炎症反応 / 肝線維化 / 炎症 / マクロファージ / ホスホリパーゼA2 / 非アルコール性脂肪肝炎 Less

Understanding the mechanisms underlying bran developmental retardation in Down syndromePrincipal Investigator
- Principal Investigator
  
  石原慶一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kyoto Pharmaceutical University
Understanding the mechanisms underlying copper accumulation in the brain with Down syndromePrincipal Investigator
- Principal Investigator
  
  石原慶一
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto Pharmaceutical University
Identification of responsible gene(s) for accumulation of copper in the brain of Down syndrome and its role in intellectual disabilityPrincipal Investigator
- Principal Investigator
  
  石原慶一
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto Pharmaceutical University
Elucidation of the pathophysiology of Alzheimer's disease by analysis of changes in the immune environment in the brain and its application to the treatment
- Principal Investigator
  
  Takata Kazuyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto Pharmaceutical University
A study on abnormal cerebrovascular function and accelerated inflammation in the developing brain with Down syndromePrincipal Investigator
- Principal Investigator
  
  Ishihara Keiichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto Pharmaceutical University
Involvement of group IVA phospholipase A2 in the development and progression of non-alcoholic steatohepatitis
- Principal Investigator
  
  Akiba Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Molecular mechanisms and enhanced inflammtion in retardation of brain development and cognitive impairment in a mouse model of Down synromePrincipal Investigator
- Principal Investigator
  
  Ishihara Keiichi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Role of oxidative stress and inflammation on the deficits of memory and learning in mouse model for Down syndromePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Keiichi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Neurochemical disturbance in a mouse model of Down syndromePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Keiichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
Studies of polyQ diseases : possible mechanisms of cell death and its prevention by molecular chaperone
- Principal Investigator
  
  HATAYAMA Takumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Pharmaceutical University
Effects of molecular chaperones on polyQ-mediated cell death and toxicity using cellular model of SBMA
- Principal Investigator
  
  HATAYAMA Takumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Pharmaceutical University

[Journal Article] Suppression of<i>Sleeping Beauty</i>-induced Gliomagenicity in Ts1Cje Mice, a Model of Down Syndrome2024
- Author(s)
  ISHIHARA KEIICHI、SAKODA RYUTO、MIZOGUCHI MASAKO、FUJITA MITSUGU、MOYAMA CHIAMI、OKUTANI YURI、TAKATA KAZUYUKI、TANAKA MIWA、MINAMI TAKASHI、SAGO HARUHIKO、YAMAKAWA KAZUHIRO、NAKAMURA TAKURO、KAWASHITA ERI、AKIBA SATOSHI、NAKATA SUSUMU
- Journal Title
  
  Anticancer Research
  
  Volume: 44 Issue: 2 Pages: 489-495
- DOI
  10.21873/anticanres.16836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07033, KAKENHI-PROJECT-22K07653, KAKENHI-PROJECT-23K06642, KAKENHI-PROJECT-23K08554, KAKENHI-PROJECT-21K09167, KAKENHI-PUBLICLY-22H04822
[Journal Article] ダウン症候群の認知機能障害と生命金属恒常性破綻2023
- Author(s)
  石原慶一
- Journal Title
  
  ファルマシア
  
  Volume: 59 Pages: 206-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07033
[Journal Article] Bio-Metal Dyshomeostasis-Associated Acceleration of Aging and Cognitive Decline in Down Syndrome2023
- Author(s)
  Ishihara Keiichi、Kawashita Eri、Akiba Satoshi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 9 Pages: 1169-1175
- DOI
  10.1248/bpb.b23-00131
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Journal Article] Plantainoside B in <i>Bacopa monniera</i> Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ2023
- Author(s)
  Fukuda Aina、Nakashima Souichi、Oda Yoshimi、Nishimura Kaneyasu、Kawashima Hidekazu、Kimura Hiroyuki、Ohgita Takashi、Kawashita Eri、Ishihara Keiichi、Hanaki Aoi、Okazaki Mizuki、Matsuda Erika、Tanaka Yui、Nakamura Seikou、Matsumoto Takahiro、Akiba Satoshi、Saito Hiroyuki、Matsuda Hisashi、Takata Kazuyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 320-333
- DOI
  10.1248/bpb.b22-00797
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06637, KAKENHI-PROJECT-22K06556, KAKENHI-PROJECT-22K07382, KAKENHI-PROJECT-21K15245, KAKENHI-PROJECT-20H03569
[Journal Article] Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases2023
- Author(s)
  Ishihara K., Takata K. & Mizutani K.
- Journal Title
  
  Life
  
  Volume: 13 Issue: 1 Pages: 221-221
- DOI
  10.3390/life13010221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06802, KAKENHI-PROJECT-22K07033, KAKENHI-PUBLICLY-22H04822
[Journal Article] ダウン症候群の認知機能障害と生命金属恒常性破綻2023
- Author(s)
  石原慶一
- Journal Title
  
  ファルマシア
  
  Volume: 59 Pages: 206-211
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Journal Article] Erg遺伝子とDown症候群に対する胎児治療の可能性2022
- Author(s)
  石原慶一、左合治彦
- Journal Title
  
  周産期医学
  
  Volume: 52 Pages: 1001-1003
- Data Source
  KAKENHI-PROJECT-22K07033
[Journal Article] ダウン症候群の知的障害における脳炎症の関連の可能性2022
- Author(s)
  石原慶一
- Journal Title
  
  糖尿病・内分泌代謝科
  
  Volume: 54 Pages: 35-41
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Journal Article] Erg遺伝子とDown症候群に対する胎児治療の可能性2022
- Author(s)
  石原慶一
- Journal Title
  
  周産期医学
  
  Volume: 52 Pages: 1001-1003
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Journal Article] The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment2022
- Author(s)
  Ishihara Keiichi
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 71 Issue: 1 Pages: 16-21
- DOI
  10.3164/jcbn.21-155
- NAID
  130008159803
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05521, KAKENHI-PROJECT-22K07033, KAKENHI-PUBLICLY-22H04822
[Journal Article] Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice2022
- Author(s)
  Kawashita E., Ozaki T., Ishihara K., Kashiwada C., AkibaS.
- Journal Title
  
  Life Sciences
  
  Volume: 294 Pages: 120355-120355
- DOI
  10.1016/j.lfs.2022.120355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07077, KAKENHI-PUBLICLY-22H04822
[Journal Article] Brain oxidative stress and pathophysiological significance in Down syndrome2021
- Author(s)
  Ishihara Keiichi
- Journal Title
  
  Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet
  
  Volume: - Pages: 83-91
- DOI
  10.1016/b978-0-12-817986-4.00008-0
- ISBN
  9780128179864
- Data Source
  KAKENHI-PUBLICLY-20H05521
[Journal Article] Brain Development Coordinated by Interactions between Neurons, Glial Cells and Central Vascular System, and Disease Caused by Its Disturbance2021
- Author(s)
  石原慶一、水谷健一
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 3 Pages: 333-334
- DOI
  10.1248/yakushi.20-00198-F
- NAID
  130007992977
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-03-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07259, KAKENHI-PROJECT-18K06940
[Journal Article] Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome2021
- Author(s)
  Yoshino Seiko、Tanaka Miwa、Sunami Yoshitaka、Takahara Tomoko、Yamazaki Yukari、Homme Mizuki、Niibori-Nambu Akiko、Osato Motomi、Minami Takashi、Ishihara Keiichi、Nakamura Takuro
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 2 Pages: 558-561
- DOI
  10.1038/s41375-021-01384-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-19K07702, KAKENHI-PROJECT-20K16318, KAKENHI-PROJECT-20K17389, KAKENHI-PUBLICLY-20H05521, KAKENHI-PROJECT-19H01035, KAKENHI-PROJECT-21H02917, KAKENHI-PROJECT-17K07199, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-18KK0440
[Journal Article] Is Neuron-Vascular Communication Disturbed in the Delayed Prenatal Brain Development of a Mouse Model of Down Syndrome?2021
- Author(s)
  Ishihara Keiichi
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 3 Pages: 369-373
- DOI
  10.1248/yakushi.20-00198-5
- NAID
  130007992978
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-03-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06940
[Journal Article] Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of Down syndrome mouse models.2021
- Author(s)
  Shimizu R, Ishihara K, Kawashita E, Sago H, Yamakawa K, Mizutani K, & Akiba S.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 535 Pages: 87-92
- DOI
  10.1016/j.bbrc.2020.12.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07259, KAKENHI-PUBLICLY-20H05521, KAKENHI-PROJECT-18K06940
[Journal Article] Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome.2020
- Author(s)
  Ishihara K, Shimizu R, Takata K, Kawashita E, Amano K, Shimohata A, Low D, Nabe T, Sago H, Alexander WS, Ginhoux F, Yamakawa K, Akiba S.
- Journal Title
  
  Brain Pathology
  
  Volume: 30 Issue: 1 Pages: 75-91
- DOI
  10.1111/bpa.12758
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06940
[Journal Article] Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome.2019
- Author(s)
  Ishihara K, Kawashita E, Shimizu R, Nagasawa K, Yasui H, Sago H, Yamakawa K, Akiba S.
- Journal Title
  
  Free Radic Biol Med.
  
  Volume: 134 Pages: 248-259
- DOI
  10.1016/j.freeradbiomed.2019.01.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06940, KAKENHI-PROJECT-16K08284
[Journal Article] Copper accumulation in the brain of Down syndrome model mice and its pathophysiological significance2019
- Author(s)
  石原慶一，河下映里，秋葉　聡
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 154 Issue: 6 Pages: 335-339
- DOI
  10.1254/fpj.154.335
- NAID
  130007754367
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06940
[Journal Article] Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.2017
- Author(s)
  Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.
- Journal Title
  
  Exp Neurol
  
  Volume: S0014-4886(17) Pages: 30069-9
- DOI
  10.1016/j.expneurol.2017.03.009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06462, KAKENHI-PROJECT-25242078, KAKENHI-PROJECT-25460077, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-15K09848
[Journal Article] A Comprehensive Diverse '-omics' Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome.2017
- Author(s)
  Ishihara K, Akiba S.
- Journal Title
  
  Brain Sciences
  
  Volume: 44 Issue: 4 Pages: 1-14
- DOI
  10.3390/brainsci7040044
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460077
[Journal Article] ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease.2015
- Author(s)
  Kanai S, Ishihara K, Kawashita E, Tomoo T, Nagahira K, Hayashi Y, Akiba S.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 356 Issue: 3 Pages: 604-614
- DOI
  10.1124/jpet.115.229906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460077, KAKENHI-PROJECT-26460110
[Journal Article] Group IVA phospholipase A2 deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.2015
- Author(s)
  Ishihara K, Kanai S, Tanaka K, Kawashita E, Akiba S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 471 Issue: 1 Pages: 15-20
- DOI
  10.1016/j.bbrc.2016.01.186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460077, KAKENHI-PROJECT-26460110
[Journal Article] Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome.2014
- Author(s)
  Keiichi Ishihara, Shiho Kanai, Hatuhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba
- Journal Title
  
  Neuroscience
  
  Volume: 281 Pages: 1-15
- DOI
  10.1016/j.neuroscience.2014.09.039
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460077
[Journal Article] Identification of Molecules with Altered Expression in the Brain of Mouse Model for Down Syndrome by Comprehensive Analyses2013
- Author(s)
  Keiichi Ishihara
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 133 Issue: 9 Pages: 989-994
- DOI
  10.1248/yakushi.13-00167
- NAID
  130003361985
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2013-09-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-25460077
[Journal Article] Triacylglycerol Deposition with Group IVC Phospholipase A2 Expression in Oleate- and Linoleate-Stimulated Huh-7 Hepatocytes2011
- Author(s)
  Ishihara K, Tachibana K, Kuroda A, Terakawa A, Baba S, Kanai S, Akiba S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 34 Issue: 2 Pages: 191-196
- DOI
  10.1248/bpb.34.191
- NAID
  130000402188
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790091
[Journal Article] Regulation of macrophage differentiation and polarization by group IVC phospholipase A_2. Biochem2011
- Author(s)
  Ishihara K., Kuroda A., Sugihara K., Kanai S., Nabe T., Akiba S
- Journal Title
  
  Biophys. Res. Commun
  
  Volume: 416 Pages: 325-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790091
[Journal Article] Triacylglycerol deposition with group IVC phospholipase A_2 expression in oleate-and linoleate-stimulated Huh-7 hepatocytes2011
- Author(s)
  Ishihara K., Tachibana K., Kuroda A., Terakawa A., Baba S., Kanai S., Akiba S
- Volume
  34
- Pages
  191-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790091
[Journal Article] Regulation of macrophage differentiation and polarization by group IVC phospholipase A22011
- Author(s)
  Ishihara K, Kuroda A, Sugihara K, Kanai S, Nabe T, Akiba S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 416 Issue: 3-4 Pages: 325-330
- DOI
  10.1016/j.bbrc.2011.11.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790091, KAKENHI-PROJECT-23590093
[Journal Article] Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome2010
- Author(s)
  Keiichi Ishihara
- Journal Title
  
  Cerebral Cortex VOL.20
  
  Pages: 1131-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790089
[Journal Article] Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.2010
- Author(s)
  Keiichi Ishihara, Kenji Amano, Eiichi Takaki, Atsushi Shimohata, Haruhiko Sago, Charles J. Epstein, Kazuhiro Yamakawa
- Journal Title
  
  Cerebral Cortex Vol.20
  
  Pages: 1131-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790089
[Journal Article] Increased lipid peroxidation in Down syndrome mouse models2009
- Author(s)
  Keiichi Ishihara
- Journal Title
  
  Journal of Neurochemistry VOL.110
  
  Pages: 1965-1976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790089
[Journal Article] Increased lipid peroxidation in Down's syndrome mouse models.2009
- Author(s)
  Keiichi Ishihara, Kenji Amano, Eiichi Takaki, Abdul S. Ebrahim, Atsushi Shimohata, Noriko Shibazaki, Ikuyo Inoue, Mayuko Takaki, Yuto Ueda, Haruhiko Sago, Charles J. Epstein, Kazuhiro Yamakawa
- Journal Title
  
  Journal of Neurochemistry Vol.110
  
  Pages: 1965-1976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790089
[Journal Article] Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs.2004
- Author(s)
  Keiichi Ishihara
- Journal Title
  
  Eur.J.Biochem. 271
  
  Pages: 4552-4558
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590915
[Journal Article] Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs.2004
- Author(s)
  Keiichi Ishihara, et al.
- Journal Title
  
  Eur.J.Biochem. 271
  
  Pages: 4552-4558
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590915
[Journal Article] Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells.2003
- Author(s)
  Keiichi Ishihara
- Journal Title
  
  Eur.J.Biochem. 270
  
  Pages: 3461-3468
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590915
[Journal Article] Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells2003
- Author(s)
  Keiichi Ishihara, et al.
- Journal Title
  
  Eur.J.Biochem. 270
  
  Pages: 3461-3468
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590915
[Journal Article] Hsp105α suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity.2003
- Author(s)
  Keiichi Ishihara
- Journal Title
  
  J.Biol.Chem 278
  
  Pages: 25143-25150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590915
[Journal Article] Hsp105α suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity2003
- Author(s)
  Keiichi Ishihara, et al.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 25143-25150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590915
[Presentation] ゲノム編集法により作製した染色体欠失マウスを用いたダウン症モデルマウス脳での銅蓄積責任遺伝子座の同定2024
- Author(s)
  巽友理奈、斉藤美知子、高田修治、河下映里、山川和弘、秋葉　聡、石原慶一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Presentation] ダウン症候群モデルマウスの脳における銅蓄積は情動記憶障害を引き起こすのか？2024
- Author(s)
  川上陽菜、千代華歩、河下映里、山川和弘、秋葉　聡、石原慶一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Presentation] Bacopa monnieraに含有されるAβ結合物質plantainoside BによるAβ凝集体の検出と神経保護作用2023
- Author(s)
  福田愛菜, 中嶋聡一, 尾田好美, 西村周泰, 河嶋秀和, 木村寛之, 扇田隆司, 河下映里, 石原慶一, 花木葵, 岡崎瑞紀, 松田英里香, 田中雪衣, 中村誠宏, 松本崇宏, 秋葉聡, 斎藤博幸, 松田久司, 高田和幸
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] ダウン症モデルマウス脳でのエンドソーム異常による銅蓄積の可能性2023
- Author(s)
  石原慶一
- Organizer
  メタルバイオサイエンス研究会2023
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Presentation] Effects of Down syndrome genes on amyloid-β aggregation in mice2022
- Author(s)
  Keiichi Ishihara, Eri Kawashita, Kaneyasu Nishimura, Michiko Saito, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba, Kazuyuki Takata
- Organizer
  The 65th Annual Meeting of the Japanese Society for Neurochemistry
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] Possible involvement of brain copper accumulation in emotional memory disturbance in multiple mouse models of Down syndrome2022
- Author(s)
  K. Ishihara, E. Kawashita, H. Sago, K. Yamakawa, S.
- Organizer
  The 8th International Symposium on Metallomics
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Presentation] Brain copper accumulation-associated cognitive impairment in mouse models of Down syndrome2022
- Author(s)
  Keiichi Ishihara
- Organizer
  10th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07033
[Presentation] Possible involvement of brain copper accumulation in emotional memory disturbance in multiple mouse models of Down syndrome.2022
- Author(s)
  Keiichi Ishihara, Eri Kawashita, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba.
- Organizer
  The 8th International Symposium on Metallomic
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07033
[Presentation] Suppressive effects of Down syndrome genes on amyloid-β aggregation and mortality in a mouse model of Alzheimer’s disease2022
- Author(s)
  Keiichi Ishihara, Eri Kawashita, Mizuki Katsuda, Michiko Saito, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba1, Kazuyuki Takata
- Organizer
  The 67th Annual Meeting of the Japan Society of Human Genetics
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] Brain Copper Accumulation-Associated Cognitive Impairment in Mouse Models of Down Syndrome2022
- Author(s)
  K. Ishihara
- Organizer
  10th Asian Biological Inorganic Chemistry Conference (AsBIC10)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04822
[Presentation] ダウン症候群での生命金属恒常性の破綻2021
- Author(s)
  石原慶一
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05521
[Presentation] ダウン症の脳発生における神経血管ユニットの破綻の可能性2021
- Author(s)
  石原慶一
- Organizer
  第64回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05521
[Presentation] ダウン症の胎生期脳発達遅滞における神経-血管相互作用異常の可能性2020
- Author(s)
  石原慶一
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] ダウン症モデルマウスの脳および肝臓を用いたメタロミクス解析2020
- Author(s)
  石原慶一、河下映里、山川和弘、左合治彦、秋葉　聡
- Organizer
  生命金属に関する合同年会
- Data Source
  KAKENHI-PUBLICLY-20H05521
[Presentation] メタロミクス解析により明らかとなったダウン症モデルマウス脳での銅蓄積とその意義2020
- Author(s)
  石原慶一
- Organizer
  フォーラム2020 衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05521
[Presentation] ダウン症モデルマウス成体脳での銅蓄積~新規治療標的としての可能性~2020
- Author(s)
  石原慶一
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] ダウン症モデルマウスと病態研究について2020
- Author(s)
  石原慶一
- Organizer
  第2回日本ダウン症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] ダウン症モデルマウスと病態研究について2020
- Author(s)
  石原慶一
- Organizer
  第2回日本ダウン症学会学術大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05521
[Presentation] ダウン症モデルマウスにおける血管新生調節転写因子の３コピー化による胎生期ニューロン新生異常.2019
- Author(s)
  石原慶一
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] Comparative elementomic analysis reveals copper accumulation in the brain in Ts1Cje, a mouse model of Down syndrome2019
- Author(s)
  Keiichi Ishihara, Eri Kawashita, Ryohei Shimizu, Hiroyuki Yasui, Kazuki Nagasawa, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba
- Organizer
  3rd International Conference of the Trisomy 21 Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] ダウン症中枢症状の治療標的候補としての銅蓄積の同定2019
- Author(s)
  石原慶一
- Organizer
  第30回日本微量元素学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] Elementomics reveals the accumulation of copper in the brain of a Down syndrome model mouse and its pathophysiological significance.2019
- Author(s)
  Keiichi Ishihara
- Organizer
  The 92nd Annual Meeting of the Japanese Pharmacological Society
- Invited
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] ダウン症モデルマウスにおける炎症性細胞数異常および大脳皮質発達遅延とその原因遺伝子の同定.2018
- Author(s)
  石原慶一、清水涼平、河下映里、ウォレンアレキサンダー、左合治彦、山川和弘、秋葉　聡
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06940
[Presentation] 細胞培養系を用いたNASH病態進展におけるIVA型phospholipase A2の機能解析．2017
- Author(s)
  今田百南，河下映里，石原慶一，江川奈生，木原　望，倉田麻未，種草大貴，秋葉　聡
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] 酸化ストレス誘発性肝線維化の進展過程におけるIVA型ホスホリパーゼA2の役割の解明．2017
- Author(s)
  福本紗与，河下映里，石原慶一，泰地健芳，秋葉　聡
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] ダウン症マウスモデル脳の異常表現型と発現変動分子2016
- Author(s)
  石原慶一
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] Comparative metallo- and element-omics profiling reveals aberrant copper contents in the brain of Ts1Cje, a mouse model for Down syndrome.2016
- Author(s)
  Ishihara K, Kawashita E, Yamakawa K, Sago H, Akiba S
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] 創薬標的の同定を目的としたダウン症マウス脳での変動分子の網羅的解析2016
- Author(s)
  石原慶一、河下映里、左合治彦、山川和弘、秋葉聡
- Organizer
  日本薬学会　136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] 酸化ストレス誘発性肝障害におけるIVA型ホスホリパーゼA2の役割．2016
- Author(s)
  藤井美恵子、河下映里、石原慶一、秋葉　聡
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] NASH進展に関与する肝細胞及びマクロファージにおける IVA型phospholipase A2の役割．2016
- Author(s)
  種草大貴、河下映里、石原慶一、秋葉聡
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  高槻
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] Characterization of abnormalities in the brain of Ts1Cje, a mouse model of Down syndrome, by multiple “-omics” techniques2015
- Author(s)
  Keiichi Ishihara1, Lisa Beppu1, Ryosuke Takekoshi1, Haruhiko Sago2, Kazuhiro Yamakawa3, Satoshi Akiba1
- Organizer
  T21RS International Conference 2015
- Place of Presentation
  Brain and Spine Institute (ICM) at the Pitié-Salpêtrière hospital (Paris)
- Year and Date
  2015-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] 動脈硬化症におけるM2型マクロファージ極性化へのIVA型ホスホリパーゼA2の関与．2015
- Author(s)
  木原　望、金井志帆、厚味厳一、河下映里、石原慶一、秋葉　聡
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] IVA型ホスホリパーゼA2の欠損による肝細胞オートファジーの促進．2015
- Author(s)
  田中紀久子、和田尚子、吉田彩奈加、河下映里、石原慶一、秋葉　聡
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪府富田林市
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] 脂肪肝形成に対する経口性IVA型ホスホリパーゼA2阻害剤の抑制効果．2014
- Author(s)
  金井志帆、倉井悠貴、古庄由佳、西川瑞稀、石原慶一、秋葉　聡
- Organizer
  第61回日本生化学会近畿支部例会
- Place of Presentation
  京都市
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] ダウン症モデルマウスの脳プロテオミクス解析による発現変動タンパク質の同定2014
- Author(s)
  竹腰良輔、石原慶一、山本美帆、金井志帆、左合治彦、山川和弘、秋葉　聡
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] ダウン症モデルマウス胎児脳において変動する分子の検索2014
- Author(s)
  古川琴江，石原慶一，金井志帆，山川和弘，左合治彦，秋葉　聡
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] ダウン症モデルマウス胎児脳における抑制性ニューロン新生異常2014
- Author(s)
  別府梨沙、石原慶一、谷口麻実、金井志帆、左合治彦、山川和弘、秋葉聡
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] 肝線維化誘発 IVA型Phospholipase A2欠損マウスにおける脾臓肥大．2014
- Author(s)
  松岡秀明、大西健太、石原慶一、金井志帆、秋葉聡
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] IVA型Phospholipase A2欠損による薬剤誘発性肝障害の抑制．2014
- Author(s)
  和田尚子、金井志帆、石原慶一、秋葉聡
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] ダウン症モデルマウスの脳プロテオミクス解析2013
- Author(s)
  石原慶一，川﨑愛弓，金井志帆，左合治彦，山川和弘，秋葉　聡
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] ダウン症候群モデルマウスの異常表現型解析2012
- Author(s)
  石原慶一、金井志帆、秋葉聡、山川和弘
- Organizer
  生物分子システムに基づく創薬科学フロンティア研究成果発表会
- Place of Presentation
  生物分子システムに基づく創薬科学フロンティア研究成果発表会
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-22790091
[Presentation] ダウン症候群モデルマウスの異常表現型解析2012
- Author(s)
  石原慶一、金井志帆、秋葉聡、山川和弘
- Organizer
  生物分子システムに基づく創薬科学フロンティア研究成果発表会
- Place of Presentation
  生物分子システムに基づく創薬科学フ京都薬科大学京都
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-22790091
[Presentation] ダウン症マウスモデルの脳における神経伝達物質量の異常と代謝異常2010
- Author(s)
  石原慶一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20790089
[Presentation] ダウン症記憶障害の治療のための新しい候補ターゲットシグナル!?(ハイライトポスター)2010
- Author(s)
  石原慶一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20790089
[Presentation] ダウン症マウスモデルの脳における神経伝達物質量の異常と代謝異常2010
- Author(s)
  石原慶一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20790089
[Presentation] ダウン症モデルマウス脳における銅濃度の増加
- Author(s)
  竹腰良輔, 金井志帆, 左合治彦, 山川和弘, 秋葉　聡, 石原慶一
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] IVA型ホスホリパーゼA2の阻害による非アルコール性脂肪肝炎の抑制作用．
- Author(s)
  金井志帆、倉井悠貴、石原慶一、秋葉　聡
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] Comparative proteomic profiling reveals aberrant cell proliferation in the embryonic brain of Ts1Cje, a mouse model for Down syndrome.
- Author(s)
  Keiichi Ishihara, Shiho Kanai, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, D.C., USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25460077
[Presentation] Suppressive effects of group IVA phospholipase A2-deficiency on the liver injury and hepatic fibrosis induced by oxidative stress in mice.
- Author(s)
  Shiho Kanai, Keiichi Ishihara, and Satoshi Akiba
- Organizer
  The Liver Meeting 2014
- Place of Presentation
  ボストン（米国）
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26460110
[Presentation] ダウン症モデルマウス胎児脳における変動分子の網羅的解析
- Author(s)
  石原慶一
- Organizer
  第63回日本薬学会近畿支部大会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25460077

1. HATAYAMA Takumi (10094484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. YAMAGISHI Nobuyuki (60298685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Takata Kazuyuki (10434664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. KANAI SHIHO (40582630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. OHTSUKA Kenzo (40150213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Akiba Satoshi (70231826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
7. KAWASHITA Eri (80509266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 西村周泰 (90527889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. MIZUTANI Kenichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 宮川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 大里元美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 南敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishihara Keiichi 石原 慶一

ISHIHARA Keiichi 石原 慶一

Research Projects

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Understanding the mechanisms underlying bran developmental retardation in Down syndromePrincipal Investigator

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Understanding the mechanisms underlying copper accumulation in the brain with Down syndromePrincipal Investigator

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Identification of responsible gene(s) for accumulation of copper in the brain of Down syndrome and its role in intellectual disabilityPrincipal Investigator

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Elucidation of the pathophysiology of Alzheimer's disease by analysis of changes in the immune environment in the brain and its application to the treatment

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A study on abnormal cerebrovascular function and accelerated inflammation in the developing brain with Down syndromePrincipal Investigator

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Involvement of group IVA phospholipase A2 in the development and progression of non-alcoholic steatohepatitis

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Molecular mechanisms and enhanced inflammtion in retardation of brain development and cognitive impairment in a mouse model of Down synromePrincipal Investigator

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Role of oxidative stress and inflammation on the deficits of memory and learning in mouse model for Down syndromePrincipal Investigator

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Neurochemical disturbance in a mouse model of Down syndromePrincipal Investigator

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Studies of polyQ diseases : possible mechanisms of cell death and its prevention by molecular chaperone

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Effects of molecular chaperones on polyQ-mediated cell death and toxicity using cellular model of SBMA

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[Journal Article] Suppression of<i>Sleeping Beauty</i>-induced Gliomagenicity in Ts1Cje Mice, a Model of Down Syndrome2024

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[Journal Article] ダウン症候群の認知機能障害と生命金属恒常性破綻2023

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Ishihara Keiichi 石原慶一

ISHIHARA Keiichi 石原慶一