HAGIHARA Shinya 萩原伸也

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HAGIHARA Shinnya 萩原伸也

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Researcher Number	80373348
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー 2018 – 2021: 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー 2016 – 2017: 名古屋大学, 理学研究科, 准教授 2015: 名古屋大学, 理学研究科(WPI), 特任准教授 2013 – 2014: 名古屋大学, 理学研究科(WPI), 准教授 2009 – 2012: 東北大学, 多元物質科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Medium-sized Section 37:Biomolecular chemistry and related fields / Bio-related chemistry / Science and Engineering / Biological Sciences / Chemistry related to living body Except Principal Investigator Chemistry related to living body
Keywords	Principal Investigator 植物ケミカルバイオロジー / ケミカルバイオロジー / 植物科学 / 植物ホルモン / 植物 / リードスルー / ナンセンス変異 / 架橋性核酸 / miRNA / 植物ケミカルバイロジー … More / ジベレリン / サイトカイニン / 花成制御 / 花成 / 遺伝情報変換 / 生体分子 / リボソーム結合分子 / 糖 / 核酸 / アンチセンス / 核酸医薬 / 革新的遺伝子治療 / 遺伝子治療 / 遺伝子疾患 / PTCリードスルー / アミノグリコシド / 核酸関連化学 … More Except Principal Investigator インテリジェント核酸 / 遺伝子発現制御 / RNA標的 / In Cell Chemistry / miRNA / オリゴDNA / クロスリンク / クロスリンク反応 / 核酸・蛋白質・糖化学 Less

Development of chemicals that improve the efficiency of plant transformationPrincipal Investigator
- Principal Investigator
  
  萩原伸也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
植物における標的タンパク質の選択的分解法Principal Investigator
- Principal Investigator
  
  萩原伸也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
Regulation of plant flowering by synthetic moleculesPrincipal Investigator
- Principal Investigator
  
  Hagihara Shinya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
Precise regulation of plant hormone perceptionPrincipal Investigator
- Principal Investigator
  
  Hagihara Shinya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
Dissection and Regulation of Plant Function with Synthetic MoleculesPrincipal Investigator
- Principal Investigator
  
  Hagihara Shinya
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Institute of Physical and Chemical Research
  Nagoya University
Amino acid substitution without genetic modificationPrincipal Investigator
- Principal Investigator
  
  Hagihara Shinya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Nagoya University
Sequence-specific read through of premature termination codonPrincipal Investigator
- Principal Investigator
  
  HAGIHARA Shinya
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bio-related chemistry
- Research Institution
  Nagoya University
架橋性核酸を用いた非コードＲＮＡ作用マシナリーの機能解析Principal Investigator
- Principal Investigator
  
  萩原伸也
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
  Tohoku University
Activation of target genes with crosslink-forming oligonucleotidePrincipal Investigator
- Principal Investigator
  
  HAGIHARA Shinya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tohoku University
Development of the Functional Molecules for Genome Targeting Chemistry
- Principal Investigator
  
  NAGATSUGI Fumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tohoku University

All 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] Development of 1,8-naphthalimide dyes for rapid imaging of subcellular compartments in plants2022
- Author(s)
  Kusano Shuhei、Nakamura Sakuya、Izumi Masanori、Hagihara Shinya
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 11 Pages: 1685-1688
- DOI
  10.1039/d1cc05798g
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06350, KAKENHI-PUBLICLY-20H04916, KAKENHI-PUBLICLY-20H05352, KAKENHI-PROJECT-19J01681, KAKENHI-PROJECT-20K15501
[Journal Article] Development of potent inhibitors for strigolactone receptor DWARF 142020
- Author(s)
  Yoshimura Masahiko、Kim Sojung F.、Takise Ryosuke、Kusano Shuhei、Nakamura Sakuya、Izumi Masanori、Yagi Akiko、Itami Kenichiro、Hagihara Shinya
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 94 Pages: 14917-14919
- DOI
  10.1039/d0cc01989e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15501, KAKENHI-PROJECT-19H05463, KAKENHI-PLANNED-17H06350, KAKENHI-PUBLICLY-20H05352, KAKENHI-PROJECT-19J01681
[Journal Article] A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair.2020
- Author(s)
  Kohei Nishimura , Ryotaro Yamada , Shinya Hagihara , Rie Iwasaki , Naoyuki Uchida , Takumi Kamura , Koji Takahashi , Keiko U Torii , Tatsuo Fukagawa
- Journal Title
  
  Nucleic acids research
  
  Volume: 48 Issue: 18 Pages: e108-e108
- DOI
  10.1093/nar/gkaa748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06611, KAKENHI-PROJECT-20K21395, KAKENHI-PROJECT-20K21422, KAKENHI-PROJECT-20K21423, KAKENHI-PROJECT-17H06167, KAKENHI-PLANNED-17H06350, KAKENHI-PLANNED-17H06476, KAKENHI-PUBLICLY-20H04883, KAKENHI-PUBLICLY-20H05389, KAKENHI-PUBLICLY-20H05409, KAKENHI-PROJECT-19H00990, KAKENHI-PROJECT-17H03695, KAKENHI-PROJECT-18H02085, KAKENHI-PROJECT-20H03208, KAKENHI-ORGANIZER-19H05670, KAKENHI-PROJECT-17KT0017
[Journal Article] A super strong engineered auxin-TIR1 pair.2018
- Author(s)
  Yamada R, Murai K, Uchida N, Takahashi K, Iwasaki R, Tada Y, Kinoshita T, Itami K, Torii KU and Hagihara S
- Journal Title
  
  Plant Cell Physiol.
  
  Volume: 59 Issue: 8 Pages: 1538-1544
- DOI
  10.1093/pcp/pcy127
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0017, KAKENHI-PLANNED-15H05956, KAKENHI-PLANNED-17H06350, KAKENHI-PLANNED-17H06476, KAKENHI-PUBLICLY-18H04777, KAKENHI-PROJECT-17H03695, KAKENHI-PROJECT-18H02085
[Journal Article] Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair2018
- Author(s)
  Uchida N, Takahashi K, Iwasaki R, Yamada R, Yoshimura M, Endo TA, Kimura S, Zhang H, Nomoto M, Tada Y, Kinoshita T, Itami K, Hagihara S and Torii KU
- Journal Title
  
  Nature Chem. Biol.
  
  Volume: 14 Issue: 3 Pages: 299-305
- DOI
  10.1038/nchembio.2555
- NAID
  120006473593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0017, KAKENHI-PROJECT-16K07408, KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05956, KAKENHI-PUBLICLY-16H01462, KAKENHI-PUBLICLY-16H01472, KAKENHI-PROJECT-15H04386, KAKENHI-PROJECT-17H03695, KAKENHI-PROJECT-15J04926, KAKENHI-PLANNED-17H06350, KAKENHI-PLANNED-17H06476, KAKENHI-PROJECT-18H02085
[Journal Article] Harnessing synthetic chemistry to probe and hijack auxin signaling.2018
- Author(s)
  Torii KU, Hagihara S, Uchida N and Takahashi K
- Journal Title
  
  New Phytol.
  
  Volume: 202 Issue: 2 Pages: 417-424
- DOI
  10.1111/nph.15337
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0017, KAKENHI-PLANNED-17H06350, KAKENHI-PLANNED-17H06476, KAKENHI-PUBLICLY-18H04777, KAKENHI-PROJECT-17H03695
[Journal Article] Rapid and reversible root growth inhibition by TIR1 auxin signalling2018
- Author(s)
  Fendrych Maty??、Akhmanova Maria、Merrin Jack、Glanc Matou?、Hagihara Shinya、Takahashi Koji、Uchida Naoyuki、Torii Keiko U.、Friml Ji??
- Journal Title
  
  Nature Plants
  
  Volume: 4 Issue: 7 Pages: 453-459
- DOI
  10.1038/s41477-018-0190-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06350, KAKENHI-PLANNED-17H06476, KAKENHI-PUBLICLY-18H04777
[Journal Article] The dynamics of strigolactone perception in Striga hermonthica: a working hypothesis2018
- Author(s)
  Tsuchiya Yuichiro、Yoshimura Masahiko、Hagihara Shinya
- Journal Title
  
  Journal of Experimental Botany
  
  Volume: 69 Issue: 9 Pages: 2281-2290
- DOI
  10.1093/jxb/ery061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0031, KAKENHI-PROJECT-15J04926, KAKENHI-PROJECT-15K07102, KAKENHI-PLANNED-17H06350, KAKENHI-PROJECT-18H02459
[Journal Article] Discovery of shoot branching regulator targeting strigolactone receptor DWARF14.2018
- Author(s)
  Yoshimura M, Sato A, Kuwata K, Inukai Y, Kinoshita T, Itami K, Tsuchiya Y, Hagihara S
- Journal Title
  
  ACS Central Science
  
  Volume: 4 Issue: 2 Pages: 230-234
- DOI
  10.1021/acscentsci.7b00554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05956, KAKENHI-PROJECT-15H04386, KAKENHI-PROJECT-15J04926, KAKENHI-PLANNED-17H06350
[Journal Article] Key Structural Elements of Unsymmetrical Cyanine Dyes for Highly Sensitive Fluorescence Turn-on DNA Probes2017
- Author(s)
  Kakishi Uno, Taeko Sasaki, Nagisa Sugimoto, Hideto Ito, Taishi Nishihara, Shinya Hagihara, Tetsuya Higashiyama, Narie Sasaki, Yoshikatsu Sato and Kenichiro Itami
- Journal Title
  
  Chem. Asian J.
  
  Volume: 12 Issue: 2 Pages: 233-238
- DOI
  10.1002/asia.201601430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00907, KAKENHI-PROJECT-15H05491, KAKENHI-PROJECT-26810057, KAKENHI-PROJECT-15K14559, KAKENHI-PROJECT-15K14542, KAKENHI-PROJECT-16H06280
[Journal Article] Synthetic small molecules that enhance the number of stomatal: C-H Functionalization chemistry for plant biology2017
- Author(s)
  Ziadi, A, Uchida, N., Kato, H., Hisamatsu, R., Sato, Y., Hagihara, S., *Itami, K., and *Torii, K.U.
- Journal Title
  
  Chem Commun
  
  Volume: 53 Issue: 69 Pages: 9632-9632
- DOI
  10.1039/c7cc04526c
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01237, KAKENHI-PLANNED-17H06350
[Journal Article] High-throughput Assay for Quantification of Aminoglycoside&-Ribosome Interaction2016
- Author(s)
  Shun Yamashita, Dominik Bergmann, Ayato Sato, Mika Nomoto, Yasuomi Tada, Hans-Ulrich Humpf, Kenichiro Itami and Shinya Hagihara
- Journal Title
  
  Chem. Lett.
  
  Volume: 45 Issue: 9 Pages: 1048-1050
- DOI
  10.1246/cl.160508
- NAID
  130005549100
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05491
[Journal Article] Probing strigolactone receptors in Striga hermonthica with fluorescence.2015
- Author(s)
  Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
- Journal Title
  
  Science
  
  Volume: 349 Issue: 6250 Pages: 864-869
- DOI
  10.1126/science.aab3831
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0031, KAKENHI-PROJECT-15K07102, KAKENHI-INTERNATIONAL-15K21750, KAKENHI-PLANNED-15H05956, KAKENHI-PROJECT-15H05491, KAKENHI-PROJECT-15J04926, KAKENHI-ORGANIZER-15H05955
[Journal Article] Development of the crosslinking reactions to RNA triggered by oxidation2014
- Author(s)
  Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Shinya Hagihara, Fumi Nagatsugi
- Journal Title
  
  Chem. Commun.
  
  Volume: 50 Issue: 30 Pages: 3951-3954
- DOI
  10.1039/c3cc49463b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J09123, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24102508, KAKENHI-PROJECT-25288073, KAKENHI-PROJECT-25620122, KAKENHI-PUBLICLY-26102710
[Journal Article] The crosslink formation of 2'-OMe oligonucleotide containing 2-amino-6-vinyl-purine protects mRNA from miRNA-mediated silencing2013
- Author(s)
  Shinya Hagihara, Wei-Chen Lin, Shuhei Kusano, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto, Fumi Nagatsugi
- Journal Title
  
  Chem Bio Chem
  
  Volume: 14 Issue: 12 Pages: 1427-1429
- DOI
  10.1002/cbic.201300382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J09123, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24102508, KAKENHI-PUBLICLY-24115701, KAKENHI-PROJECT-25288073
[Journal Article] Production of truncated protein by the crosslink formation of mRNA with 2’-OMe oligoribonucleotide containing 2-amino-6-vinylpurine2012
- Author(s)
  Hagihara, S., Kusano, S., Lin, W.C., Chao, X.G., Hori, T., Imoto, S., Nagatsugi, F.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 12 Pages: 3870-3872
- DOI
  10.1016/j.bmcl.2012.04.123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659002, KAKENHI-PROJECT-23750180, KAKENHI-PROJECT-23790146, KAKENHI-PUBLICLY-24102508, KAKENHI-PUBLICLY-24115701
[Journal Article] Alteration of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects2010
- Author(s)
  S. Imoto, T. Hori, S. Hagihara, Y. Taniguchi, S. Sasaki, F. Nagatsugi
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 20 Pages: 6121-6124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350086
[Journal Article] Alteration of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects2010
- Author(s)
  Imoto, S.; Hori, T.; Hagihara, S.; Taniguchi, Y.; Sasaki, S.; Nagatsugi, F
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 20 Pages: 6121-6124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350086
[Journal Article] Production of truncated protein by the crosslink formation of mRNA with 2'-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
- Author(s)
  Hagihara, S., Kusano, S., Lin, W. C., Chao, X. G., Hori, T., Imoto, S., Nagatsugi, F.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350086
[Patent] デンプンまたはグリコーゲン検出用試薬およびキット、デンプンまたはグリコーゲンの検出方法、ならびに新規の化合物2022
- Inventor(s)
  草野修平、中村咲耶、泉正範、萩原伸也
- Industrial Property Rights Holder
  草野修平、中村咲耶、泉正範、萩原伸也
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Development of Chemical Tools for Plant Science2022
- Author(s)
  萩原伸也
- Organizer
  CMCB2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] 植物ホルモン受容体の機能制御2021
- Author(s)
  萩原伸也
- Organizer
  酵素工学研究会第85回講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02085
[Presentation] 分子で実現する迅速育種技術2021
- Author(s)
  萩原伸也
- Organizer
  日本植物バイオテクノロジー学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Precise regulation of plant hormone signaling by combining synthetic chemistry and biology2021
- Author(s)
  萩原伸也
- Organizer
  Pacifichem 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] 植物ホルモン受容体の機能制御2021
- Author(s)
  萩原伸也
- Organizer
  酵素工学研究会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] 植物ホルモン受容体を介したシグナル伝達の精密制御2018
- Author(s)
  萩原伸也
- Organizer
  第18回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Regulation of plant hormone signaling with synthetic molecules2018
- Author(s)
  萩原伸也
- Organizer
  ACS on Campus University of Tokyo & RIKEN
- Invited
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] 植物ホルモンシグナルの人工的制御2018
- Author(s)
  萩原伸也
- Organizer
  日本農芸化学会2018年度大会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Synthetic approach toward site-specific control of plant hormone signaling2018
- Author(s)
  山田遼太郎・Letitia Sarah・岩崎理恵・高橋宏二・打田直行・木下俊則・鳥居啓子・伊丹健一郎・萩原伸也
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Sequence-specific Readthrough of Termination Codon by Antisense Oligonucleotides2018
- Author(s)
  YAMASHITA, Shun; ITAMI, Kenichiro; HAGIHARA, Shinya
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-15H05491
[Presentation] 人工分子を用いた植物の機能制御2018
- Author(s)
  萩原伸也
- Organizer
  第一回分子夾雑関東地区シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] 人工分子を用いた植物ホルモンシグナルの制御2018
- Author(s)
  萩原伸也
- Organizer
  第2回植物成長調節物質若手研究会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Probing auxin signaling with synthetic auxin-engineered receptor pair2017
- Author(s)
  Ryotaro Yamada, Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Masahiko Yoshimura, Hua Zhang, Toshinori Kinoshita, Kenichiro Itami, Keiko U. Torii, Shinya Hagihara
- Organizer
  The Second International Symposium on Biofunctional Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] 新規リボソーム結合性分子の迅速スクリーニング2017
- Author(s)
  山下　隼・佐藤　綾人・伊丹　健一郎・萩原　伸也
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶応大学
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15H05491
[Presentation] Small molecules that regulate plant hormone signaling2017
- Author(s)
  Shinya Hagihara
- Organizer
  The Second International Symposium on Biofunctional Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] Discovery of germination inhibitor for parasitic plant Striga2017
- Author(s)
  Masahiko Yoshimura, Yuichiro Tsuchiya, Ayato Sato, Yoshikatsu Sato, Keiko Kuwata, Toshinori Kinoshita, Kenichiro Itami, Shinya Hagihara
- Organizer
  The Second International Symposium on Biofunctional Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06350
[Presentation] High throughput screening for the novel translation regulator2017
- Author(s)
  Shun Yamashita, Ayato Sato, Kenichiro Itami, Shinya Hagihara
- Organizer
  グリーン自然科学国際教育研究プログラム IGER 2016年度年次報告会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-15H05491
[Presentation] 新規翻訳制御分子の探索に向けたスクリーニング法の開発2015
- Author(s)
  山下隼・佐藤綾人・野元美佳・多田安臣・伊丹健一郎・萩原伸也
- Organizer
  第3回バイオ関連化学シンポジウム若手フォーラム
- Place of Presentation
  熊本
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-15H05491
[Presentation] 新規リボソーム結合性分子の探索2015
- Author(s)
  山下隼・萩原伸也・佐藤綾人・野元美佳・多田安臣・伊丹健一郎
- Organizer
  第9回バイオ関連化学シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-15H05491
[Presentation] 立体配座を固定化した新規架橋性分子の開発2013
- Author(s)
  井田裕太、草野修平、岩本直生、萩原伸也、永次史
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学
- Year and Date
  2013-03-25
- Data Source
  KAKENHI-PROJECT-23750180
[Presentation] Development of the Oxidation Induced Cross-link Reaction2013
- Author(s)
  Shuhei Kusano, Takuya Haruyama, Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PUBLICLY-24115701
[Presentation] 架橋性オリゴ核酸を用いた細胞内遺伝子発現制御2013
- Author(s)
  萩原伸也
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学
- Data Source
  KAKENHI-PROJECT-23750180
[Presentation] 架橋性オリゴ核酸を用いた細胞内遺伝子発現制御2013
- Author(s)
  萩原伸也、草野修平、井田裕太、岩本直生、永次史
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学
- Year and Date
  2013-03-25
- Data Source
  KAKENHI-PROJECT-23750180
[Presentation] 架橋性塩基を導入したPNAオリゴマーの合成および反応性評価2012
- Author(s)
  石澤悠樹、佐々木要、萩原伸也、永次史
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶應義塾大学、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 糖部修飾型架橋反応性ピリミジン誘導体の合成と評価2012
- Author(s)
  草野修平、萩原伸也、茂木琢磨、永次史
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶應義塾大学、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Development of Crosslink Forming Oligonucleotides for Intracellular Gene Regulation2012
- Author(s)
  Shinya Hagihara
- Organizer
  第３９回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PUBLICLY-24115701
[Presentation] 機能性オリゴ核酸のRNAへの架橋形成による遺伝子発現制御2012
- Author(s)
  萩原伸也、草野修平、鈔暁光、岩本直生、永次史
- Organizer
  第92日本化学会春季年会
- Place of Presentation
  神奈川
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-23750180
[Presentation] 架橋反応性核酸を用いた効率的蛋白質発現阻害2012
- Author(s)
  永次史、萩原伸也、草野修平、井本修平
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学、北海道
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 機能性オリゴ核酸のRNAへの架橋形成による遺伝子発現制御2012
- Author(s)
  萩原伸也、草野修平、Chao Xio Guang, 岩本直生、永次史
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶應義塾大学、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 2'-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011
- Author(s)
  萩原伸也、井本修平、鈔暁光、堀恒晃、草野修平、永次史
- Organizer
  第38際核酸化学シンポウム
- Place of Presentation
  札幌
- Year and Date
  2011-11-09
- Data Source
  KAKENHI-PROJECT-23750180
[Presentation] 架橋反応性ピリミジン誘導体の合成と評価2011
- Author(s)
  草野修平、萩原伸也、永次史
- Organizer
  第5回バイオ関連化学シンポジウム
- Place of Presentation
  つくば国際会議場「エポカルつくば」、茨城県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Development of Cross-linking Agents with Highly Selective Reactivity to a Target Base2011
- Author(s)
  F. Nagatsugi, S. Hagihara, S. Kusano, C. X. Guang
- Organizer
  6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Cambridge, United Kingdom
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] グリコシル化を鍵反応とした架橋反応性を有するピリミジン誘導体の合成と評価2011
- Author(s)
  草野修平、萩原伸也、永次史
- Organizer
  第22回万有仙台シンポジウム
- Place of Presentation
  仙台国際センター,宮城県
- Year and Date
  2011-12-22
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Development of Acyclic Nucleoside Analogs with Selective Cross-linking to Guanine2011
- Author(s)
  S.Kusano, S.Hagihara, T.Moki, F.Nagatsugi
- Organizer
  The 38th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 架橋反応性を有する直鎖状ヌクレオシド類縁体の開発2011
- Author(s)
  草野修平、萩原伸也、茂木琢真、永次史
- Organizer
  第11回多元物質科学研究所研究発表会
- Place of Presentation
  東北大学片平キャンパス・さくらホール、宮城県
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 細胞内遺伝子発現制御に向けた架橋性核酸の開発2011
- Author(s)
  萩原伸也、井本修平、堀常晃、X. Chao、永次史
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 核酸医薬を目指したチミン選択的クロスリンク剤の開発2011
- Author(s)
  永次史、井本修平、萩原伸也、堀常晃、Cho Xio. Guang
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡大学、静岡県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 架橋反応性ピリミジン誘導体の合成と評価2011
- Author(s)
  草野修平、萩原伸也、永次史
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2011
- Place of Presentation
  大阪大学、大阪府
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Design of the novel artificial molecules for the control of gene expression2011
- Author(s)
  F. Nagatsugi, S. Hagihara, S. Kusano
- Organizer
  International Symposium on Engineering Neo-Biomimetics II-Soft Nanomaterials and Soft Robotics-
- Place of Presentation
  AIST Tsukuba Central, Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 細胞内における遺伝子発現制御を目指した自己活性化架橋反応性核酸の開発2011
- Author(s)
  永次史、萩原伸也、草野修平、Chao Xiao Guang、茂木琢真
- Organizer
  第60回高分子討論会
- Place of Presentation
  岡山大学、岡山県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] グリコシル化を鍵反応とした架橋反応性を有するピリミジン誘導体の合成2011
- Author(s)
  草野修平、萩原伸也、永次史
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 2'-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011
- Author(s)
  萩原伸也、井本修平、鈔暁光、堀恒晃、草野修平、永次史
- Organizer
  第38回国際核酸化学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23750180
[Presentation] Evaluation of the Antisense Effects Using the Reactive Oligonucleotides with High Selectivity to the Target Base2011
- Author(s)
  F.Nagatsugi, T.Hori, S.Kusano, S.Imoto, S.Hagihara, C.H.Guang
- Organizer
  AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 架橋性オリゴ核酸による遺伝子発現制御2011
- Author(s)
  萩原伸也、井本修平、堀常晃、鈔暁光、永次史
- Organizer
  第6回日本ケミカルバイオロジー年会
- Place of Presentation
  東京工業大学大岡山キャンパス、東京都
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Dependency of the Cross-linking Reactivity with 2-Amino-6-vinylpurine on the Neighboring Bases2011
- Author(s)
  S. Hagihara, S. Kusano, C. X. Guang, F. Nagatsugi
- Organizer
  7th Anual Meeting of the oligonucleotides theraputic society
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 架橋性核酸を用いたmRNAの機能制御2011
- Author(s)
  萩原伸也、草野修平、岩本直生、Chao Xiao Guang、永次史
- Organizer
  第11回多元物質科学研究所研究発表会
- Place of Presentation
  東北大学片平キャンパス・さくらホール、宮城県
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] グアニンを標的とした架橋反応性ピリミジン誘導体の開発2011
- Author(s)
  草野修平、萩原伸也、茂木琢真、永次史
- Organizer
  グローバルCOEプログラム分子系高次構造体化学国際教育研究拠点シンポジウム2011
- Place of Presentation
  東北大学片平キャンパス・さくらホール、宮城県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Evaluation of the Antisense Effects Using the Reactive Oligonucleotides with High Selectivity to the Target Base2011
- Author(s)
  F. Nagatsugi, T. Hori, S. Kusano, S. Imoto, S. Hagihara, C. H. Guang
- Organizer
  8th AFMC International Medicinal Chemistry Symposium"Frontier of Medicinal Science"
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 2'-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011
- Author(s)
  S. Hagihara, S. Imoto, C. X. Guang, S. Kusano, F. Nagatsugi
- Organizer
  The 38th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 架橋反応性の制御因子解明を目指したビニルプリン誘導体の合成2011
- Author(s)
  櫻庭誠也、Chao Xiao Guang、萩原伸也、永次史
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Crosslink forming oligonucleotide that enhances translation in cells2010
- Author(s)
  S. Hagihara, W.-C. Lin, S. Imoto, T. Hori, F. Nagatsugi
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Hamagin Hall"VIA MARE", Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] チミンとの架橋反応性を有する新規人工核酸の開発2010
- Author(s)
  井本修平、服部恵一、草野修平、廣濱智哉、萩原伸也、永次史
- Organizer
  第5回日本ケミカルバイオロジー年会
- Place of Presentation
  慶應義塾大学日吉キャンパス、神奈川県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 反応性核酸を導入した2'-OMeオリゴRNAを用いたアンチセンス効果及びmiRNAの阻害2010
- Author(s)
  永次史、萩原伸也、堀常晃、井本修平
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学ポートアイランドキャンパス
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Development of the Effective Cross-linking Reaction to Target Gene2010
- Author(s)
  F.Nagatsugi, T.Hori, S.Kusano, S.Imoto, S.Hagihara
- Organizer
  Pacifichem 2010
- Place of Presentation
  Hawaii, USA
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Cross-linking reactions with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects2010
- Author(s)
  S. Imoto, T. Hori, C. X. Guang, S. Hagihara, Y. Taniguchi, S. Sasaki., F. Nagatsugi
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Hamagin Hall"VIA MARE", Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Crosslink forming oligonucleotide that enhances translation in cells (The 37th International Symposium on Nucleic Acids Chemistry2010
- Author(s)
  S.Hagihara, W.-C.Lin, S.Imoto, T.Hori, F.Nagatsugi
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Hamagin Hall "VIA MARE", Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] チミンとの架橋反応性を有する新規人工核酸の開発2010
- Author(s)
  井本修平、服部恵一、草野修平、廣濱智哉、萩原伸也、永次史
- Organizer
  第5回日本ケミカルバイオロジー年会
- Place of Presentation
  慶應義塾大学日吉キャンパス協生館
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 2本鎖形成により活性化されるクロスリンク反応の開発2010
- Author(s)
  永次史、井本修平、堀常晃、萩原伸也、谷口陽祐、佐々木茂貴
- Organizer
  第59回高分子討論会
- Place of Presentation
  北海道大学高等教育機能開発総合センター
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 2本鎖形成により活性化されるクロスリンク反応の開発2010
- Author(s)
  永次史、井本修平、堀常晃、萩原伸也、谷口陽祐、佐々木茂貴
- Organizer
  第59回高分子討論会
- Place of Presentation
  北海道大学高等教育機能開発総合センター、北海道
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 新規反応性核酸の開発及びmiRNA阻害に向けた検討2010
- Author(s)
  永次史、堀常晃、井本修平、草野修平、萩原伸也
- Organizer
  第10回遺伝子デリバリー研究会シンポジウム
- Place of Presentation
  北海道大学学術交流会館、北海道
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Development of the effective cross-linking reaction to target gene2010
- Author(s)
  F. Nagatsugi., T. Hori, S. Kusano, S. Imoto, S. Hagihara
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 架橋性核酸を用いた遺伝子発現制御2010
- Author(s)
  萩原伸也、井本修平、堀常晃、永次史
- Organizer
  第10回多元物質科学研究所研究発表会
- Place of Presentation
  東北大学片平キャンパス・さくらホール仙台
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Cross-linking Reactions with the 2'-OMe Analogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense Effects2010
- Author(s)
  S.Imoto, T.Hori, C.X.Guang, S.Hagihara, Y.Taniguchi, S.Sasaki, F.Nagatsug
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Hamagin Hall "VIA MARE", Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] チミン選択的クロスリンク剤の合成と評価2010
- Author(s)
  櫻庭誠也、萩原伸也、永次史
- Organizer
  第10回多元物質科学研究所研究発表会
- Place of Presentation
  東北大学片平キャンパス・さくらホール仙台
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 反応性核酸を導入した2'-OMeオリゴRNAを用いたアンチセンス効果及びmiRNAの阻害2010
- Author(s)
  永次史、萩原伸也、堀常晃、井本修平
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学ポートアイランドキャンパス、兵庫県
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] Development of the cross-linking reactions to thymine with high selectivity2010
- Author(s)
  S. Imoto, T. Hori, K. Hattori, S. Kusano, S. Hagihara, Y. Taniguchi, S. Sasaki, F. Nagatsugi
- Organizer
  IRT 2010-XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 新規反応性核酸の開発及びmiRNA阻害に向けた検討2010
- Author(s)
  永次史、堀常晃、井本修平、草野修平、萩原伸也
- Organizer
  第10回遺伝子デリバリー研究会シンポジウム
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-21350086
[Presentation] 2'修飾型反応性核酸の合成2009
- Author(s)
  堀常晃、井本修平、萩原伸也、永次史
- Organizer
  第9回多元物質科学研究所研究発表会
- Place of Presentation
  東北大学片平キャンパス・さくらホール(仙台)
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21350086

1. IMOTO Syuhei (20447189)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
2. NAGATSUGI Fumi (90208025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 44 results
3. YAMASHITA Shun

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. UCHIDA Naoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. KUWATA Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SATO Ayato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中村咲耶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 伊藤英人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 西村浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 鳥居啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 土屋雄一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 望田啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 木下俊則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAGIHARA Shinya 萩原 伸也

HAGIHARA Shinnya 萩原 伸也

Research Projects

Research Products

Co-Researchers

Development of chemicals that improve the efficiency of plant transformationPrincipal Investigator

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植物における標的タンパク質の 選択的分解法Principal Investigator

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Regulation of plant flowering by synthetic moleculesPrincipal Investigator

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Precise regulation of plant hormone perceptionPrincipal Investigator

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Dissection and Regulation of Plant Function with Synthetic MoleculesPrincipal Investigator

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Amino acid substitution without genetic modificationPrincipal Investigator

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Sequence-specific read through of premature termination codonPrincipal Investigator

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架橋性核酸を用いた非コードＲＮＡ作用マシナリーの機能解析Principal Investigator

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Activation of target genes with crosslink-forming oligonucleotidePrincipal Investigator

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Development of the Functional Molecules for Genome Targeting Chemistry

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[Journal Article] Development of 1,8-naphthalimide dyes for rapid imaging of subcellular compartments in plants2022

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[Journal Article] Development of potent inhibitors for strigolactone receptor DWARF 142020

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[Journal Article] A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair.2020

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HAGIHARA Shinya 萩原伸也

HAGIHARA Shinnya 萩原伸也

植物における標的タンパク質の選択的分解法Principal Investigator