NAKAMURA Kiminori 中村公則

Researcher Number	80381276
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 先端生命科学研究院, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北海道大学, 先端生命科学研究院, 教授 2016 – 2022: 北海道大学, 先端生命科学研究院, 准教授 2015: 北海道大学, 大学院先端生命科学研究院, 准教授 2015: 北海道大学, 大学院先端生命科学研究院自然免疫研究室, 准教授 2013 – 2015: 北海道大学, 先端生命科学研究科(研究院), 准教授 … More 2012: 北海道大学, 先端生命科学研究科(研究院), 助教 2011 – 2012: 北海道大学, 大学院・先端生命科学研究院, 助教 2010: 北海道大学, 大学院・先端生命科学研究院, 特任助教 2009: 札幌医大, 医学部, 講師 2004 – 2009: 札幌医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Pathobiological dentistry/Dental radiology / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 59040:Nutrition science and health science-related / Morphological basic dentistry / Surgical dentistry Except Principal Investigator Biological Sciences / Basic Section 53020:Cardiology-related / Food science / Applied biochemistry / Radiation science / Gastroenterology
Keywords	Principal Investigator Paneth細胞 / αディフェンシン / 自然免疫 / 幹細胞 / 腸管上皮細胞 / 腸内環境 / 母乳オリゴ糖 / 先制医療 / 共生 / 腸内細菌 … More / 炎症 / 感染 / 免疫 / α-defensin / 細胞・組織 / 新規腫瘍マーカー … More Except Principal Investigator 自然免疫 / 膵癌 / 腸内細菌叢 / 腸内細菌 / αディフェンシン / アデノウイルスベクター / 遺伝子治療 / モノクローナル抗体 / 前立腺癌 / B細胞系の腫瘍 / 悪性神経膠腫 / 悪性黒色腫 / IoT / ICT / パーソナルヘルスレコード / 心血管病 / 機械学習モデル / デジタルヘルス / パーソナル・ヘルス・レコード / ミネラル / 制御 / 再生・分化 / 代謝 / 神経系 / 栄養吸収 / パネト細胞 / 腸内環境 / 悪性化 / 医食同源 / 膵がん / 膵腸相関 / 血中シトルリン / αdefensin / 放射線性腸炎 / 陽子線治療 / 強度変調放射線治療 / α-defensin / 放射線腸炎 / αデイフェンシン / 抗菌ペプチド / 潰瘍性大腸炎 / クローン病 / 炎症性腸疾患 / アテノイルスベクター / 遺伝子冶療 / 標的化遺伝子導入 / 標的化抗体 / アデノウィルスベクター / ファイバー / がん / ペプチドリガンド / 受容体 / 悪性脳腫瘍 / 安全性評価 / 膀胱癌 / 口腔癌 / NG2 / モノクローン抗体 / 分子標的 / がん治療 / ファイバー変異型 / アデノウイルス / アデノウルスベクター Less

Elucidation of the mechanism of development of the intestinal environment via intestinal epithelial stem cell niche activity mediated by milk oligosaccharides.Principal Investigator
- Principal Investigator
  
  Nakamura Kiminori
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Hokkaido University
PHRを活用した機械学習モデルによる心血管病の重症化予防を目指した研究
- Principal Investigator
  
  横田卓
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hokkaido University
Understanding mechanisms of disease development via disrupted Paneth cell development involving maturation and formation of intestinal microbiotaPrincipal Investigator
- Principal Investigator
  
  Nakamura Kiminori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hokkaido University
Elucidation of homeostatic mechanism via intestinal environment regulated by oral bacteriaPrincipal Investigator
- Principal Investigator
  
  Nakamura Kiminori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University
Pancreatic-Intestinal Crosstalk: a novel approach to elucidate the tumorigenic process of PDAC
- Principal Investigator
  
  ONO Yusuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied biochemistry
- Research Institution
  Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital
Elucidation of the interplay between oral bacteria and intestinal innate immunity using Paneth cells in organoid culturesPrincipal Investigator
- Principal Investigator
  
  Nakamura Kiminori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University
Paneth cells and their networks as headquarters for clarifying food function
- Principal Investigator
  
  Sakuragi Naoya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Food science
- Research Institution
  Hokkaido University
To investigate the clinical application of alpha-defensin in stool in the objective evaluation of radiation enteritis
- Principal Investigator
  
  Onodera Shunsuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido Cancer Center(Department of Clinical Research)
  Hokkaido University
αディフェンシンによる腸内細菌の統御機構からみた炎症性腸疾患の病因解明と新規治療
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
Effect of oral bacteria on intestinal innate immunityPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Kiminori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hokkaido University
口腔癌の分子標的化よる新規治療法・診断法の開発Principal Investigator
- Principal Investigator
  
  中村公則
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University
Selective targeted drug and gene delivery for cancer treatment
- Principal Investigator
  
  HAMADA Hirohumi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
腫瘍の特異的標的化を目指した遺伝子治療法の開発
- Principal Investigator
  
  HAMADA Hirohumi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University

[Journal Article] Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice2024
- Author(s)
  YONOICHI Sakura、HARA Yukako、ISHIDA Yuya、SHODA Asuka、KIMURA Mako、MURATA Midori、NUNOBIKI Sarika、ITO Makiko、YOSHIMOTO Ayano、MANTANI Youhei、YOKOYAMA Toshifumi、HIRANO Tetsushi、IKENAKA Yoshinori、YOKOI Yuki、AYABE Tokiyoshi、NAKAMURA Kiminori、HOSHI Nobuhiko
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 86 Issue: 3 Pages: 277-284
- DOI
  10.1292/jvms.23-0514
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19846, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K25004
[Journal Article] Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions2023
- Author(s)
  Wang Yi、Song Yuchi、Yan Shaonan、Hiramine Rina、Ohnishi Yuki、Yokoi Yuki、Nakamura Kiminori、Kikukawa Takashi、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Antibiotics
  
  Volume: 12 Issue: 6 Pages: 1047-1047
- DOI
  10.3390/antibiotics12061047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Associations between Maternal Diet, Human Milk Macronutrients, and Breast-Fed Infant Growth during the First Month of Life in the SMILE Iwamizawa in Japan2023
- Author(s)
  Komatsu Yosuke、Wada Yasuaki、Tabata Fuka、Kawakami Satomi、Takeda Yasuhiro、Nakamura Kiminori、Ayabe Tokiyoshi、Nakamura Koshi、Kimura Takashi、Tamakoshi Akiko
- Journal Title
  
  Nutrients
  
  Volume: 15 Issue: 3 Pages: 654-654
- DOI
  10.3390/nu15030654
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891
[Journal Article] A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites2023
- Author(s)
  Gan Li、Inamura Yuga、Shimizu Yu、Yokoi Yuki、Ohnishi Yuki、Song Zihao、Kumaki Yasuhiro、Kikukawa Takashi、Demura Makoto、Ito Masaaki、Ayabe Tokiyoshi、Nakamura Kiminori、Aizawa Tomoyasu
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 9 Pages: 1003-1003
- DOI
  10.3390/metabo13091003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04849, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production2023
- Author(s)
  Shimizu Yu、Yamamura Ryodai、Yokoi Yuki、Ayabe Tokiyoshi、Ukawa Shigekazu、Nakamura Koshi、Okada Emiko、Imae Akihiro、Nakagawa Takafumi、Tamakoshi Akiko、Nakamura Kiminori
- Journal Title
  
  Gut Microbes
  
  Volume: 15 Issue: 1 Pages: 2190306-2190306
- DOI
  10.1080/19490976.2023.2190306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-21H02891
[Journal Article] Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis2023
- Author(s)
  Song Zihao、Ohnishi Yuki、Osada Seiji、Gan Li、Jiang Jiaxi、Hu Zhiyan、Kumeta Hiroyuki、Kumaki Yasuhiro、Yokoi Yuki、Nakamura Kiminori、Ayabe Tokiyoshi、Yamauchi Kazuo、Aizawa Tomoyasu
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 5 Pages: 611-611
- DOI
  10.3390/metabo13050611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation2023
- Author(s)
  Song Yuchi、Wang Yi、Yan Shaonan、Nakamura Kiminori、Kikukawa Takashi、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Microbial Cell Factories
  
  Volume: 22 Issue: 1 Pages: 9-9
- DOI
  10.1186/s12934-023-02016-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PUBLICLY-22H05389, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K23843
[Journal Article] Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota2023
- Author(s)
  Nakamura Shunta、Nakamura Kiminori、Yokoi Yuki、Shimizu Yu、Ohira Shuya、Hagiwara Mizu、Song Zihao、Gan Li、Aizawa Tomoyasu、Hashimoto Daigo、Teshima Takanori、Ouellette Andre J.、Ayabe Tokiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3953-3953
- DOI
  10.1038/s41598-023-30997-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08409, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0054, KAKENHI-PROJECT-20K21610, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-23K21439
[Journal Article] Oral frailty and carriage of oral Candida in community‐dwelling older adults (Check‐up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa)2022
- Author(s)
  Baba Haruhisa, Watanabe Yutaka, Miura Kazuhito, Ozaki Kimiya, Matsushita Takae, Kondoh Miyako, Okada Kazutaka, Hasebe Akira, Ayabe Tokiyoshi, Nakamura Kiminori, Nakaoka Shinji, Ogasawara Katsuhiko, Suzuki Teppei, Saito Hiroshi, Kimura Takashi, Tamakoshi Akiko, Yamazaki Yutaka
- Journal Title
  
  Gerodontology
  
  Volume: 39 Issue: 1 Pages: 49-58
- DOI
  10.1111/ger.12621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09903, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K20331, KAKENHI-PROJECT-23K20334
[Journal Article] Efficient and simple genetic engineering of enteroids using mouse isolated crypts for investigating intestinal functions2022
- Author(s)
  Ohira Shuya、Yokoi Yuki、Ayabe Tokiyoshi、Nakamura Kiminori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 637 Pages: 153-160
- DOI
  10.1016/j.bbrc.2022.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0054
[Journal Article] Ingestion of miso regulates immunological robustness in mice2022
- Author(s)
  Kotake Kunihiko、Kumazawa Toshihiko、Nakamura Kiminori、Shimizu Yu、Ayabe Tokiyoshi、Adachi Takahiro
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 1 Pages: e0261680-e0261680
- DOI
  10.1371/journal.pone.0261680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891
[Journal Article] Intestinal commensal microbiota and cytokines regulate Fut2 <sup>+</sup> Paneth cells for gut defense2022
- Author(s)
  Kamioka Mariko、Goto Yoshiyuki、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Ohira Shuya、Kurashima Yosuke、Umemoto Shingo、Sato Shintaro、Kunisawa Jun、Takahashi Yu、Domino Steven E.、Renauld Jean-Christophe、Nakae Susumu、Iwakura Yoichiro、Ernst Peter B.、Ayabe Tokiyoshi、Kiyono Hiroshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 3 Pages: 1-10
- DOI
  10.1073/pnas.2115230119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-21H02963, KAKENHI-PROJECT-20J11528, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21K19494, KAKENHI-PROJECT-19K17452, KAKENHI-PROJECT-18H05280
[Journal Article] Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota2022
- Author(s)
  Chen Xuanzhong、Hashimoto Daigo、Ebata Ko、Takahashi Shuichiro、Shimizu Yu、Shinozaki Ryuga、Hasegawa Yuta、Kikuchi Ryo、Senjo Hajime、Yoneda Kazuki、Zhang Zixuan、Harada Shinpei、Hayase Eiko、Ara Takahide、Ohigashi Hiroyuki、Iwakura Yoichiro、Nakamura Kiminori、Ayabe Tokiyoshi、Teshima Takanori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 48 Pages: 1-10
- DOI
  10.1073/pnas.2211230119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08409, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K16259, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0033, KAKENHI-PROJECT-20K21610, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-23K21439
[Journal Article] Hemodynamic response to intestinal pH stimulation measured with spectroscopic video imaging2022
- Author(s)
  Funane Tsukasa、Yokoi Yuki、Kikuchi Masashi、Shinozaki Ryuga、Ayabe Tokiyoshi、Atsumori Hirokazu、Nishimura Ayako、Nakamura Kiminori、Kandori Akihiko
- Journal Title
  
  Biomedical Physics & Engineering Express
  
  Volume: 9 Issue: 1 Pages: 017001-017001
- DOI
  10.1088/2057-1976/aca20a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0033
[Journal Article] Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption2022
- Author(s)
  Sato Yuji、Wang Yi、Song Yuchi、Geng Weiming、Yan Shaonan、Nakamura Kiminori、Kikukawa Takashi、Demura Makoto、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Amino Acids
  
  Volume: 54 Issue: 2 Pages: 289-297
- DOI
  10.1007/s00726-021-03115-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891
[Journal Article] Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method2021
- Author(s)
  Yokoi Y, Adachi T, Sugimoto R, Kikuchi M, Ayabe T, Nakamura K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 545 Pages: 14-19
- DOI
  10.1016/j.bbrc.2021.01.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-20J11528
[Journal Article] Disease progression-associated alterations in fecal metabololies in SAMP1/YitFc mice, a Crohn’s disease model2020
- Author(s)
  Komatsu Y, Shimizu Y, Yamano M, Kikuchi M, Nakamura K, Ayabe T, Aizawa T
- Journal Title
  
  Metabolomics
  
  Volume: 16 Issue: 4 Pages: 48-48
- DOI
  10.1007/s11306-020-01671-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098
[Journal Article] Mycotoxin deoxynivalenol has different impacts on intestinal barrier and stem cells by its route of exposure2020
- Author(s)
  Hanyu H, Yokoi Y, Nakamura K, Ayabe T, Tanaka K, Uno K, Miyajima K, Saito Y, Iwatsuki K, Shimizu M, Tadaishi M, Kobayashi-Hattori K
- Journal Title
  
  Toxins
  
  Volume: 12 Issue: 10 Pages: 610-610
- DOI
  10.3390/toxins12100610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-18K05480
[Journal Article] Expression and localization of Paneth cells and their alpha-defensins in the small intestine of adult mouse2020
- Author(s)
  Nakamura K, Yokoi Y, Fukaya R, Ohira S, Shinozaki R, Nishida T, Kikuchi M, Ayabe T
- Journal Title
  
  Front Immunol
  
  Volume: 11 Pages: 570296-570296
- DOI
  10.3389/fimmu.2020.570296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999
[Journal Article] Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-Switching LC-MS/MS2020
- Author(s)
  Hirabayashi Y, Nakamura K, Sonehara T, Suzuki D, Hanzawa S, Shimizu Y, Aizawa T, Nakamura K, Tamakoshi A, Ayabe T
- Journal Title
  
  Mass Spectrometry
  
  Volume: 9 Issue: 1 Pages: A0081-A0081
- DOI
  10.5702/massspectrometry.A0081
- NAID
  130007823248
- ISSN
  2186-5116, 2187-137X
- Year and Date
  2020-03-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-20H04098
[Journal Article] Paneth cell alpha-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice2020
- Author(s)
  Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, Nakamura S, Ohira S, Sugimoto R, Ayabe T
- Journal Title
  
  Life Science Alliance
  
  Volume: 3 Issue: 6 Pages: e201900592-e201900592
- DOI
  10.26508/lsa.201900592
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-20J11528
[Journal Article] Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids2020
- Author(s)
  Yamamura R, Nakamura K, Kitada N, Aizawa T, Shimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 39 Issue: 1 Pages: 11-17
- DOI
  10.12938/bmfh.19-010
- NAID
  130007788976
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-20H04098
[Journal Article] Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.2019
- Author(s)
  Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
- Journal Title
  
  PLoS One
  
  Volume: 26;14(2):e0211244 Issue: 2 Pages: 1-21
- DOI
  10.1371/journal.pone.0211244
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-18H02788
[Journal Article] A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice2019
- Author(s)
  Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A
- Journal Title
  
  In Vitro Cell Dev Biol - Animal
  
  Volume: 55 Issue: 6 Pages: 436-444
- DOI
  10.1007/s11626-019-00359-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K11661
[Journal Article] Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells2019
- Author(s)
  Takakuwa Akiko、Nakamura Kiminori、Kikuchi Mani、Sugimoto Rina、Ohira Shuya、Yokoi Yuki、Ayabe Tokiyoshi
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 11 Pages: 2817-2817
- DOI
  10.3390/nu11112817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17931, KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-17K11661
[Journal Article] Essential role of IFN-γ in T cell?associated intestinal inflammation2018
- Author(s)
  Eriguchi Yoshihiro、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Takahashi Shuichiro、Hashimoto Daigo、Teshima Takanori、Ayabe Tokiyoshi、Selsted Michael E.、Ouellette Andre J.
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 18 Pages: 1-18
- DOI
  10.1172/jci.insight.121886
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09945, KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-17H04206, KAKENHI-PROJECT-18H02788
[Journal Article] Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells.2018
- Author(s)
  Yaguchi K, Yamamoto T, Shimada M, Sugimoto R, Nakamura K, Ayabe T, Uehara R.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 504 Issue: 1 Pages: 231-231
- DOI
  10.1016/j.bbrc.2018.08.160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K15111
[Journal Article] Entamoeba histolytica Alters ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency.2018
- Author(s)
  Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K
- Journal Title
  
  Infect Immiune
  
  Volume: 21;86(10) Issue: 10
- DOI
  10.1128/iai.00564-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11661
[Journal Article] R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease2017
- Author(s)
  Hayase E, Hashimoto D, Nakamura K, Noizat C, Ogasawara R, Takahashi S, Ohigashi H, Yokoi Y, Sugimoto R, Matsuoka S, Ara T, Yokoyama E, Yamakawa T, Ebata K, Kondo T, Hiramine R, Aizawa T, Ogura Y, Hayashi T, Mori H, Kurokawa K, Tomizuka K, Ayabe T, Teshima T
- Journal Title
  
  J Exp Med
  
  Volume: 214 Issue: 12 Pages: 3507-3518
- DOI
  10.1084/jem.20170418
- NAID
  120006394569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09945, KAKENHI-PROJECT-17K11661
[Journal Article] Paneth cell α-defensins and enteric microbiota in health and disease2016
- Author(s)
  Nakamura K, Sakuragi N, Takakuwa A, Ayabe T.
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 35 Issue: 2 Pages: 57-67
- DOI
  10.12938/bmfh.2015-019
- NAID
  130005150071
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26660100, KAKENHI-PROJECT-26462831
[Journal Article] Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization.2015
- Author(s)
  Tomisawa S, Sato Y, Kamiya M, Kumaki Y, Kikukawa T, Kawano K, Demura M, Nakamura K, Ayabe T, Aizawa T.
- Journal Title
  
  Protein Expr Purif.
  
  Volume: 112 Pages: 21-28
- DOI
  10.1016/j.pep.2015.04.007
- NAID
  120005820696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01805, KAKENHI-PROJECT-26440072, KAKENHI-PROJECT-26462831
[Journal Article] Stiff Substrates Increase YAP-Signaling-Mediated Matrix Metalloproteinase-7 Expression2015
- Author(s)
  A. Nukuda, C. Sasaki, S. Ishihara, T. Mizutani, K. Nakamura, T. Ayabe, K. Kawabata, and H. Haga
- Journal Title
  
  Oncogenesis
  
  Volume: 4 Issue: 9 Pages: e165-e165
- DOI
  10.1038/oncsis.2015.24
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430104, KAKENHI-PROJECT-26462831, KAKENHI-PROJECT-25287106
[Journal Article] 腸における排除と共生 ―抗菌ペプチドと腸内細菌―2015
- Author(s)
  綾部時芳、櫻木直也、中村公則
- Journal Title
  
  家畜感染症学会学会誌
  
  Volume: 4 Pages: 133-141
- NAID
  40021598126
- Data Source
  KAKENHI-PROJECT-26660100
[Journal Article] Bacterial cell wall components regulate adipokine secretion from visceral adipocytes2015
- Author(s)
  Taira R,Yamaguchi S, Shimizu K,Nakamura K, Ayabe T,Taira T.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 56 Issue: 2 Pages: 149-154
- DOI
  10.3164/jcbn.14-74
- NAID
  130004879378
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462831
[Journal Article] Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope.2015
- Author(s)
  Ikeda M, Yamaguchi M, Kato K, Nakamura K, Shiina S, Ichikawa-Ando T, Misaka H, Myojo K, Nakamura K, Sugimoto Y, Hamada H.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 458 Pages: 877-882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462831
[Journal Article] Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope.2015
- Author(s)
  Ikeda M, Yamaguchi M, Kato K, Nakamura K, Shiina S, Ichikawa-Ando T, Misaka H, Myojo K, Nakamura K, Sugimoto Y, Hamada H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 458(4) Pages: 877-882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462831
[Journal Article] 腸上皮細胞の抗菌ペプチドによる自然免疫.2015
- Author(s)
  中村公則, 綾部時芳.
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 64 Pages: 20-25
- Data Source
  KAKENHI-PROJECT-26462831
[Journal Article] Decreased secretion of Paneth cell α-defensins in graft-versus-host disease.2015
- Author(s)
  Eriguchi Y, Nakamura K, Hashimoto D, Shimoda S, Shimono N, Akashi K, Ayabe T, Teshima T
- Journal Title
  
  Transplant Infectious Disease
  
  Volume: 17 Issue: 5 Pages: 702-706
- DOI
  10.1111/tid.12423
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461438, KAKENHI-PROJECT-26462831
[Journal Article] Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells.2014
- Author(s)
  Yamaguchi M, Nishii Y, Nakamura K, Aoki H, Hirai S, Uchida H, Sakuma Y, Hamada H.
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 454 Issue: 4 Pages: 600-603
- DOI
  10.1016/j.bbrc.2014.10.133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059, KAKENHI-PROJECT-26462831
[Journal Article] Intracellular superoxide dismutase activity defines invasiveness of the murine T-lymphoma cell line L5187Y-ML25 in vitro and in vivo.2013
- Author(s)
  Tanaka M
- Journal Title
  
  Leuk Res
  
  Volume: 37 Issue: 1 Pages: 89-92
- DOI
  10.1016/j.leukres.2012.07.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193, KAKENHI-PROJECT-24390147, KAKENHI-PROJECT-24590700
[Journal Article] Intracellular superoxide dismutase activity defines invasiveness of the murine T-lymphoma cell line L5187Y-ML25 in vitro and in vivo2013
- Author(s)
  Tanaka M, Kuribayashi K, Kogawa K, NakamuraK , Watanabe N
- Journal Title
  
  Leuk Res
  
  Volume: 37(1) Pages: 89-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Graft-versus-host disease disrup ts intestinal microbial ecology by i nhibiting Paneth cell production of α-defensins2012
- Author(s)
  Eriguchi Y, Takashima S 他10名
- Journal Title
  
  Blood
  
  Volume: 120巻 Issue: 1 Pages: 223-231
- DOI
  10.1182/blood-2011-12-401166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390295, KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193, KAKENHI-PROJECT-23659490, KAKENHI-PROJECT-24790977
[Journal Article] Paneth cells and stem cells in tne intestinal stem cell niche and their association with inflammatory bowel disease2012
- Author(s)
  Nakamura K, Ayabe T
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 32 Pages: 53-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390193
[Journal Article] Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease2012
- Author(s)
  NakamuraK , Ayabe T
- Journal Title
  
  Inflammation Regeneration.
  
  Volume: 32 Pages: 53-60
- NAID
  130004482294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Paneth cells and stem cells in the intestinal stem-cell niche and their association with inflamatory bowel disease2012
- Author(s)
  Nakamura K, Ayabe T
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 32 Pages: 53-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins2012
- Author(s)
  Eriguchi Y, Takashima S, Oka H, Shimoji S, Nakamura K , Uryu H, Shimoda S, Iwasaki H, Shimono N, Ayabe T, Akashi K, Teshima T
- Journal Title
  
  Blood
  
  Volume: 120 (1) Pages: 223-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] 腸内環境を制御するPaneth細胞αディフェンシン2012
- Author(s)
  綾部時芳、中村公則
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 57(1) Pages: 25-31
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Regulation of microbiota by antimicrobial peptides in the gut2011
- Author(s)
  Masuda K, Nakamura K, Yoshioka S, Fukaya R, Sakai N, Ayabe T
- Journal Title
  
  Adv Otorhinolaryngol
  
  Volume: 72 Pages: 97-99
- DOI
  10.1159/000324625
- ISBN
  9783805597227, 9783805597234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193
[Journal Article] Bactericidal activity of mouse α-defensin cryptdin-4 predominantly affects noncommensal bacteria2011
- Author(s)
  Masuda K, Sakai N, Nakamura K, Yoshioka S, Ayabe T
- Journal Title
  
  J Innate Immun
  
  Volume: 3 Issue: 3 Pages: 315-326
- DOI
  10.1159/000322037
- NAID
  120002989233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193
[Journal Article] αディフェンシンによる腸内細菌制御2011
- Author(s)
  中村公則、綾部時芳
- Journal Title
  
  実験医学
  
  Volume: 29(18) Pages: 2955-2961
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Regulation of microbiota by antimicrobial peptides in the gut2011
- Author(s)
  Masuda K, NakamuraK , Yoshioka S, Fukaya R, Sakai N, Ayabe T
- Journal Title
  
  Adv Otorhinolaryngol
  
  Volume: 72 Pages: 97-9
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus2011
- Author(s)
  Kawashima R, Abei M, Fukuda K, NakamuraK , Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK
- Journal Title
  
  Int J Cancer
  
  Volume: 129 (5) Pages: 1244-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy2011
- Author(s)
  Takahashi S, Kato K, NakamuraK , Nakano R, Kubota K, Hamada H
- Journal Title
  
  Cancer Sci
  
  Volume: 102(4) Pages: 808-14
- NAID
  10029292451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Bactericidal activity of mouse α-defensin cryptdin-4 predominantly affects noncommensal bacteria2011
- Author(s)
  Masuda K, Sakai N, NakamuraK , Yoshioka S, Ayabe T
- Journal Title
  
  J Innate Immun
  
  Volume: 3(3) Pages: 315-26
- NAID
  120002989233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029
[Journal Article] Gene transfer of CD40-ligand to dendritic cells stimulates interferon-γproduction to induce growth arrest and apoptosis of tumor cells.2008
- Author(s)
  Tomihara K, Kato K, Masuta Y, Nakamura K, Uchida H, Sasaki K, Tanaka T, Huang J, Hiratsuka H, Hamada H
- Journal Title
  
  Gene Therapy 15
  
  Pages: 203-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016059
[Journal Article] Selective gene transfer into neurons via Na, K-ATPase beta1. Targeting gene transfer with monoclonal antibody and adenovirus vector.2008
- Author(s)
  Ishii K, Nakamura K, Kawaguchi S, Li R, Hirai S, Sakuragi N, Wada T, Kato K, Yamashita T, Hamada H
- Journal Title
  
  J. Gene Med. 10(6)
  
  Pages: 597-609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016059
[Journal Article] Gene transfer of the CD40-ligand to human dendritic cells induces NK-mediated antitumor effects against human carcinoma cells.2007
- Author(s)
  Tomihara K, Kato K, Masuta Y, Nakamura K, Tanaka T, Hiratsuka H, Hamada H
- Journal Title
  
  Int. J. Cancer 120(7)
  
  Pages: 1491-1498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016059
[Journal Article] Gene transfer of noncleavable cell surface mutants of human CD154 induces the immune response and diminishes systemic inflammatory reactions.2007
- Author(s)
  Masuta Y, Kato K, Tomihara K, Nakamura K, Sasaki K, Takahashi S, Hamada H
- Journal Title
  
  J. Immunother. 30(7)
  
  Pages: 694-704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016059
[Journal Article] Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model.2005
- Author(s)
  Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Ishii K, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O, Houkin K, Date I, Hamada H
- Journal Title
  
  Mol. Ther. 11(1)
  
  Pages: 96-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016059
[Journal Article] Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rat.2005
- Author(s)
  Huang J, Nakamura K, Ito Y, Uzuka T, Morikawa M, Hirai S, Tomihara K, Tanaka T, Masuta Y, Ishii K, Kato K, Hamada H
- Journal Title
  
  Circulation 112(1)
  
  Pages: 76-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016059
[Patent] IL-13Ra2に対する抗体およびこれを含む診断・治療薬2009
- Inventor(s)
  濱田洋文、加藤和則、中村公則
- Industrial Property Rights Holder
  札幌医大
- Industrial Property Number
  2007-147478
- Filing Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-17016059
[Patent] PAP2aに対する抗体ならびにその診断的および治療的使用2008
- Inventor(s)
  濱田洋文、加藤和則、中村公則
- Industrial Property Rights Holder
  札幌医大
- Acquisition Date
  2008-03-21
- Data Source
  KAKENHI-PROJECT-17016059
[Patent] PAP2aに対する抗体ならびにその診断的および治療的使用2008
- Inventor(s)
  濱田加藤中村
- Industrial Property Rights Holder
  札幌医大
- Acquisition Date
  2008-03-21
- Data Source
  KAKENHI-PROJECT-17016059
[Patent] PAP2aに対する抗体ならびにその診断的および治療的使用2007
- Inventor(s)
  濱田加藤中村
- Industrial Property Rights Holder
  札幌医大
- Filing Date
  2007-12-10
- Overseas
- Data Source
  KAKENHI-PROJECT-17016059
[Patent] PAP2aに対する抗体ならびにその診断的および治療的使用2006
- Inventor(s)
  濱田, 加藤, 中村
- Industrial Property Rights Holder
  北海道
- Filing Date
  2006
- Data Source
  KAKENHI-PROJECT-17016059
[Presentation] Selective Paneth cell granule secretion in response to pathogenic and commensal bacteria in enteric mucosal immunity2024
- Author(s)
  Yuki Yokoi, Shuya Ohir, Haruto Matsuoka, Shota Takemi, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] Paneth細胞αディフェンシンが担う腸内細菌叢の形成からみた母子の疾患リスク上昇メカニズムの理解2023
- Author(s)
  中村公則
- Organizer
  第77回日本栄養・食糧学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] 小腸上皮細胞機能の分子メカニズム解明に向けた高効率かつ簡便な遺伝子改変enteroidの作製法の確立2023
- Author(s)
  松下稜, 横井友樹, 大平修也, 松岡温音, 竹見祥大, 中村公則
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] Paneth細胞・αディフェンシンによる自然免疫機能を介した腸内細菌叢制御2023
- Author(s)
  中村公則
- Organizer
  日本食品免疫学会第19回学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] 高齢者におけるPaneth細胞α-defensin分泌量の低さは加齢に伴う腸内細菌叢の遷移に関連する2022
- Author(s)
  清水由宇, 中村公則, 菊池摩仁, 鵜川重和, 中村幸志, 岡田恵美子, 今江章宏, 中川貴史, 山村凌大, 玉腰暁子, 綾部時芳
- Organizer
  第26回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] 抗菌ペプチドαディフェンシンによる腸内細菌制御と健康．2022
- Author(s)
  綾部時芳、横井友樹、清水由宇、中村公則
- Organizer
  日本食品・機械研究会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 食品が誘導するPaneth細胞αディフェンシンによる免疫と共生2022
- Author(s)
  綾部時芳, 横井友樹, 高桑暁子, 中村公則
- Organizer
  第18回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] High-efficient genetic engineering of enteroids using mouse isolated crypts revealing the intestinal function2022
- Author(s)
  大平修也, 横井友樹, 海堀唯人, 清水由宇, 綾部時芳, 中村公則
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 腸管恒常性維持における病原菌と常在菌の選択的センシングによるPaneth細胞顆粒分泌調節2022
- Author(s)
  横井友樹, 大平修也, 松岡温音, 海堀唯人, 篠崎竜我, 綾部時芳, 中村公則
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] High-efficient genetic engineering of enteroids using mouse isolated crypts revealing the intestinal function2022
- Author(s)
  大平修也, 横井友樹, 海堀唯人, 清水由宇, 綾部時芳, 中村公則
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] 高齢者におけるPaneth細胞α-defensin分泌量の低さは加齢に伴う腸内細菌叢の遷移に関連する2022
- Author(s)
  清水由宇, 中村公則, 菊池摩仁, 鵜川重和, 中村幸志, 岡田恵美子, 今江章宏, 中川貴史, 山村凌大, 玉腰暁子, 綾部時芳
- Organizer
  第26回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 腸管恒常性維持における病原菌と常在菌の選択的センシングによるPaneth細胞顆粒分泌調節2022
- Author(s)
  横井友樹, 大平修也, 松岡温音, 海堀唯人, 篠崎竜我, 綾部時芳, 中村公則
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] 食品が誘導するPaneth細胞αディフェンシンによる免疫と共生2022
- Author(s)
  綾部時芳, 横井友樹, 高桑暁子, 中村公則
- Organizer
  第18回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19120
[Presentation] Paneth細胞顆粒分泌応答からみた食機能評価系の確立2021
- Author(s)
  横井友樹、中村公則、高桑暁子、菊池摩仁,綾部時芳
- Organizer
  第17回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Dynamics of Paneth Cell Granule Secretory Responses to Bacteria in Innate Enteric Immunity2021
- Author(s)
  Yuki Yokoi, Kiminori Nakamura, Shuya Ohira, Ryuga Shinozaki, Mani Kikuchi, Tokiyoshi Ayabe
- Organizer
  World Microbe Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Simple and efficient genetic engineering of enteroids by using mouse isolated crypts．2021
- Author(s)
  Shuya Ohira, Yuki Yokoi, Mani Kikuchi, Natsumi Yatsuzuka, Tokiyoshi Ayabe, Kiminori Nakamura．
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] ER-Stress-Associated Misfolding of Paneth cell α-defensin Induces Dysbiosis and ileitis in a Murine Model of Crohn’s Disease2021
- Author(s)
  Yu Shimizu, Kiminori Nakamura, Aki Yoshii, Yuki Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, Tokiyoshi Ayabe
- Organizer
  World Microbe Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 母親の高脂肪食摂取が子のPaneth細胞の発達に与える作用メカニズム2021
- Author(s)
  八塚夏美、杉本理菜、大平修也、横井友樹、菊池摩仁、綾部時芳、中村公則
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Paneth細胞αディフェンシンによる腸内細菌形成からみた健康と病気2021
- Author(s)
  中村公則
- Organizer
  東洋大学ライフイノベーション研究所シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Paneth細胞の機能異常は腸内細菌叢の破綻を介してNASH発症に関与する2020
- Author(s)
  中村駿太、中村公則、菊池摩仁、横井友樹、大平修也、清水由宇、西田琢人、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 膵癌初期発生における膵腸相関2020
- Author(s)
  小野裕介、中村公則、清水由宇、横井友樹、杉本理菜、早川祐子、佐藤裕基、水上裕輔、奥村利勝、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 腸内環境がα-defensin isoformの殺菌活性に及ぼす影響2020
- Author(s)
  篠崎竜我、中村公則、清水由宇、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] クローン病モデルマウスSAMP1/YitFcの慢性回腸炎の免疫病態2020
- Author(s)
  村山綾菜、中村公則、菊池摩仁、横井友樹、綾部時芳
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Paneth細胞αディフェンシンによる腸内細菌叢制御を介した生体恒常性の維持機構2020
- Author(s)
  中村公則、綾部時芳
- Organizer
  第75回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] 出生早期からのPaneth細胞発達により制御される腸内細菌定着機構2020
- Author(s)
  西田琢人、中村公則、横井友樹、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Paneth細胞が担う腸内細菌叢の形成からみた疾患リスク上昇メカニズムの理解2020
- Author(s)
  中村公則、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04098
[Presentation] Acetylcholine-induced Paneth Cell Granule Secretion Via Muscarinic M3 Receptor In Mouse Small Intestine2019
- Author(s)
  Yuki Yokoi, Kiminori Nakamura, Rina Sugimoto, Shuya Ohira, Mani Kikuchi, Tokiyoshi Ayabe
- Organizer
  ASCB EMBO 2019 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] 母親の高脂肪食摂取が子のPaneth細胞α-defensinによる腸内環境制御に与える影響2019
- Author(s)
  杉本理菜、中村公則、嶋七海、清水由宇、横井友樹、綾部時芳
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] 多様なα-defensin isoformに対するin vitroにおける効率的なS-S結合導入法の確立2019
- Author(s)
  篠崎竜我、中村公則、清水由宇、綾部時芳
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] Paneth cell dysfunction in pathophysiology of nonalcoholic steatohepatitis.2019
- Author(s)
  Shunta Nakamura, Kiminori Nakamura, Mani Kikuchi, Yuki Yokoi, Shuya Ohira, Yu Shimizu, Takuto Nishida, Tokiyoshi Ayabe
- Organizer
  ASCB EMBO 2019 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] 母親の高脂肪食摂取が子の腸管上皮幹細胞ニッシェに与える影響2019
- Author(s)
  嶋七海、中村公則、杉本理菜、横井友樹、綾部時芳
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] Enteroidを用いたPaneth細胞が制御する腸内環境の機能解明2018
- Author(s)
  中村公則、横井友樹、米田司、綾部時芳
- Organizer
  日本農芸化学会2018年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] レスベラトロール摂取によるα-defensin 分泌量と腸内細菌叢への影響2018
- Author(s)
  中村公則、杉本理菜、横井友樹、清水由宇、菊池摩仁、綾部時芳
- Organizer
  日本食品免疫学会第14回学術大会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] 腸管organoidを用いたPaneth細胞分化制御機構の解析2018
- Author(s)
  大平修也、中村公則、菊池摩仁、横井友樹、杉本理菜、綾部時芳
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] Involvement of Paneth cell alpha-defensin misfolding in disease progression of SAMP1/YitFc, a murine model of Crohn's disease.2018
- Author(s)
  Yu Shimizu, Kiminori Nakamura, Mani Kikuchi, Tokiyoshi Ayabe
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] Evaluation system for receptor expression and function in the intestinal stem cell niche2017
- Author(s)
  Rina Sugimoto, Naoya Sakuragi, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] クローン病モデルマウスSAMP1/YitFcにおけるPaneth細胞α-defensinのmisfolding2017
- Author(s)
  清水由宇、中村公則、菊池摩仁、櫻木直也、綾部時芳
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] 高純度ソーティング由来cDNAライブラリーを用いたPaneth細胞の新規機能探索2017
- Author(s)
  櫻木直也、中村公則、横井友樹、菊池摩仁、綾部時芳
- Organizer
  日本食品免疫学会第13回学術大会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] Enteroid内腔へのマイクロインジェクションによるPaneth細胞顆粒分泌評価システムの確立と応用2017
- Author(s)
  米田司、中村公則、横井友樹、大平修也、菊池摩仁、櫻木直也、綾部時芳
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K11661
[Presentation] クローン病モデルマウスSAMP1/YitFcの病態形成に伴うdysbiosisとα-defensinの高次構造異常との関連2016
- Author(s)
  清水由宇, 中村公則, 吉井彩季, 菊池摩仁, 櫻木直也, 綾部時芳
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] Enteroidを用いたPaneth細胞の機能可視化～顆粒分泌･再形成および免疫系クロストーク2016
- Author(s)
  綾部時芳、横井友樹、櫻木直也、中村公則
- Organizer
  日本農芸化学会2016年度大会シンポジウム
- Place of Presentation
  札幌コンベンションセンター (北海道・札幌市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] Enteroidを用いたPaneth細胞顆粒分泌反応の可視化解析による機序解明2016
- Author(s)
  横井友樹, 中村公則, 櫻木直也, 菊池摩仁, 綾部時芳
- Organizer
  第12回日本食品免疫学会学術大会
- Place of Presentation
  伊藤謝恩ホール（東京都・文京区）
- Year and Date
  2016-11-09
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] 腸からみれば！食品と免疫と腸内細菌がつくる“腸内環境”の解明と実用化2016
- Author(s)
  綾部時芳、櫻木直也、中村公則
- Organizer
  日本農芸化学会2016年度大会　フォーラム
- Place of Presentation
  札幌コンベンションセンター (北海道・札幌市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] 同位体顕微鏡で小腸の吸収機能を視る．2015
- Author(s)
  櫻木直也、中村公則、綾部時芳、永田康祐、坂本直哉、圦本尚義
- Organizer
  第6回安定同位元素イメージング技術による産業イノベーションシンポジウム
- Place of Presentation
  北海道大学学術交流会館（北海道　札幌市）
- Year and Date
  2015-03-02
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] 同位体顕微鏡で小腸の吸収機能を視る2015
- Author(s)
  櫻木直也、中村公則、綾部時芳、永田康祐、坂本直哉、圦本尚義
- Organizer
  第6回安定同位元素イメージング技術による産業イノベーションシンポジウム
- Place of Presentation
  北海道大学学術交流会館（北海道　札幌市）
- Year and Date
  2015-03-02
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] クローン病モデルマウスSAMP1/Yitの病態進行とq-defensinの分泌異常2015
- Author(s)
  中村公則、櫻木直也、綾部時芳
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] 大麦若葉末がαディフェンシン分泌に与える影響2015
- Author(s)
  森川琢海、北村整一、鍔田仁人、山口和也、高橋欣也、櫻木直也、中村公則、綾部時芳
- Organizer
  日本食品化学工学会第62回大会
- Place of Presentation
  北里大学コンベンションホール (東京都・港区)
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] クローン病モデルマウス SAMP1/YitFc の病態形成における Paneth 細胞の関与2015
- Author(s)
  吉井彩季、櫻木直也、中村公則、綾部時芳
- Organizer
  第19回腸内細菌学会
- Place of Presentation
  仙台国際センター (宮城県・仙台市)
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] 放射線腸炎の指標としての便中α-ディフェンシンの可能性～マウスでの研究結果から～2015
- Author(s)
  小野寺俊輔、中村公則、西山典明、綾部時芳、白土博樹
- Organizer
  第133回日本医学放射線学会　北日本地方会
- Place of Presentation
  仙台市　艮陵会館
- Year and Date
  2015-10-23
- Data Source
  KAKENHI-PROJECT-25461899
[Presentation] 腸管星細胞株を用いた腸管線維化機序の解析2015
- Author(s)
  菅原徹也、中村公則、櫻木直也、綾部時芳
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場 (兵庫県・神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] クローン病モデルマウスSAMP1/YitFcの病態形成におけるα-defensinの関与2015
- Author(s)
  吉井彩季、中村公則、櫻木直也、綾部時芳
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場 (兵庫県・神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] クローン病モデルマウスSAMP1/Yitの病態進行とα-defensinの分泌異常2015
- Author(s)
  中村公則、櫻木直也、綾部時芳
- Organizer
  第19回腸内細菌学会　シンポジウム
- Place of Presentation
  仙台国際センター (宮城県・仙台市)
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] Deficiency of secreted cryptdin-4 detected in a mouse model of Crohn ' s disease using a new sandwich ELISA2012
- Author(s)
  Nakamura K
- Organizer
  Experimental Biology 2012
- Place of Presentation
  San Diego Convention Center (USA)
- Year and Date
  2012-04-25
- Data Source
  KAKENHI-PROJECT-22592029
[Presentation] Selection and regulation of intestinal microbiota by Paneth cell α-defensins2011
- Author(s)
  Ayabe T, Nakamura K
- Organizer
  XIII International Union of Microbiological Societies 2011 Congress (IUMS2011)
- Place of Presentation
  札幌コンベンションセンター(北海道)(招待講演)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] Foods-induced innate immune responses of Paneth cell ・ -defensin uncover novel functions of foods2011
- Author(s)
  Ayabe T, Kuroichi A, Kobayashi M, Nakamura K
- Organizer
  International Society for Nutraceuticais and Functional Foods Annual Conference (ISNFF2011)
- Place of Presentation
  ロイトン札幌(北海道)(招待講演)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] 腸内細菌を制御するαディフェンシンから疾病を眺める
- Author(s)
  綾部時芳、櫻木直也、中村公則
- Organizer
  第51回日本消化器免疫学会総会
- Place of Presentation
  京都大学医学部芝蘭会館（京都府　京都市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] 抗菌ペプチドαディフェンシンによる腸内環境の恒常性制御と疾病．
- Author(s)
  綾部時芳、櫻木直也、中村公則
- Organizer
  第20回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  順天堂大学（東京都　文京区）
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] 抗菌ペプチドαディフェンシンによる腸内環境の恒常性制御と疾病
- Author(s)
  綾部時芳、櫻木直也、中村公則
- Organizer
  第20回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  順天堂大学（東京都　文京区）
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] Deficiency of secreted cryptdin-4 detected in a mouse model of Crohn’s disease using a new sandwich ELISA.
- Author(s)
  Nakamura K
- Organizer
  Experimental Biology 2012
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-22592029
[Presentation] Paneth細胞α-defensinによる腸内細菌叢制御と疾患との関連の解明．
- Author(s)
  中村公則、櫻木直也、綾部時芳
- Organizer
  生理学研究所研究会「粘膜免疫学と膜輸送生理学の融合」
- Place of Presentation
  自然科学研究機構生理学研究所（愛知県　岡崎市）
- Year and Date
  2014-10-27 – 2014-10-28
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] Development of antifibrotic therapy targeted to stellate cells for intestinal fibrosis in Crohn's disease
- Author(s)
  Konno M, Nakamura K, Maruyama K, Ayabe T.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] Paneth細胞α-defensinによる腸内細菌叢制御と疾患との関連の解明
- Author(s)
  中村公則、櫻木直也、綾部時芳
- Organizer
  2014年度生理学研究所研究会
- Place of Presentation
  自然科学研究機構生理学研究所（愛知県　岡崎市）
- Year and Date
  2014-10-27 – 2014-10-28
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] 高脂肪食による肥満における抗菌ペプチドα-defensin分泌の関与
- Author(s)
  川田綾香、中村公則、櫻木直也、綾部時芳
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県　横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26660100
[Presentation] 高脂肪食による肥満における抗菌ペプチドα-defensin分泌の関与．
- Author(s)
  川田綾香、中村公則、櫻木直也、綾部時芳
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県　横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] 組織常在型M2マクロファージ細胞の培養系の確立と間葉系細胞への影響について．
- Author(s)
  藤岡明博、櫻木直也、中村公則、古澤和也、佐々木直樹、綾部時芳、福井彰雅
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県　横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] 腸内細菌を制御するαディフェンシンから疾病を眺める．
- Author(s)
  綾部時芳、櫻木直也、中村公則
- Organizer
  第51回日本消化器免疫学会総会
- Place of Presentation
  京都大学医学部芝蘭会館（京都府　京都市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26462831
[Presentation] Deficiency of secreted cryptdin-4 detected in a mouse model of Crohn’s disease using a new sandwich ELISA
- Author(s)
  Nakamura K, Kuroishi A, Kono M, Kobayashi M, Ayabe T.
- Organizer
  Experimental Biology 2012
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23390193

1. HAMADA Hirohumi (00189614)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. KATO Kazunori (60233780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. HAMA Susumu (60438041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. YAMAGUCHI Miki (10530454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Onodera Shunsuke (30374458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ONO Yusuke (40742648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Sakuragi Naoya (80420660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
8. 本望修 (90285007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤克礼 (80332914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐々木勝則 (60336394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 綾部時芳 (90301019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. 水上裕輔 (30400089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 前本篤男 (40400113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 横田卓 (90374321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中岡慎治 (30512040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKASHIMA Shuichirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. AIZAWA Tomoyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. ABE Takae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. KONDOH Miyako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. ITO Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. SATO Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 河野敬一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 芳賀永

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 橋本大吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
25. 山崎裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 岡田和隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 高桑暁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 内田宏昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAMURA Kiminori 中村 公則

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of development of the intestinal environment via intestinal epithelial stem cell niche activity mediated by milk oligosaccharides.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PHRを活用した機械学習モデルによる心血管病の重症化予防を目指した研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding mechanisms of disease development via disrupted Paneth cell development involving maturation and formation of intestinal microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of homeostatic mechanism via intestinal environment regulated by oral bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pancreatic-Intestinal Crosstalk: a novel approach to elucidate the tumorigenic process of PDAC

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the interplay between oral bacteria and intestinal innate immunity using Paneth cells in organoid culturesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Paneth cells and their networks as headquarters for clarifying food function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

To investigate the clinical application of alpha-defensin in stool in the objective evaluation of radiation enteritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

αディフェンシンによる腸内細菌の統御機構からみた炎症性腸疾患の病因解明と新規治療

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of oral bacteria on intestinal innate immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔癌の分子標的化よる新規治療法・診断法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Selective targeted drug and gene delivery for cancer treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍の特異的標的化を目指した遺伝子治療法の開発

Principal Investigator

Project Period (FY)

Research Category

NAKAMURA Kiminori 中村公則