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horibata yasuhiro  堀端 康博

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HORIBATA YASUHIRO  堀端 康博

HORIBATA Yasuhiro  堀端 康博

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Researcher Number 80392116
Other IDs
Affiliation (Current) 2025: 獨協医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2024: 獨協医科大学, 医学部, 准教授
2017 – 2019: 獨協医科大学, 医学部, 講師
2012 – 2015: 獨協医科大学, 医学部, 助教
2009: Dokkyo Medical University, 医学部, 助教
2008 – 2009: Dokkyo Medical University, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 48040:Medical biochemistry-related / Structural biochemistry / General medical chemistry
Except Principal Investigator
General medical chemistry
Keywords
Principal Investigator
リン脂質 / ミトコンドリア / 骨格筋 / 脂質輸送 / 脂質 / ミオパチー / 細胞内脂質輸送 / CPT1 / CERT / EPT1 … More / アルキルアシルグリセロール / プラズマローゲン / 細胞内輸送 / ホスファチジルコリン / 筋分化 / 呼吸鎖 / lipid / mitochondria / phospholipid / 生体分子 / StarD / ホスプアチジルコリン … More
Except Principal Investigator
YY1 / HMG-CoA reductase / 25-hydroxycholesterol / Cytidylyltransferase / CTP:phosphoethanolamine / Phosphatidylethanolamine / Yin Yang1 / コレステロール / ホスファチジルエタノールアミン / 25-ヒドロキシコレステロール / NF-Y / HMG-CoAレダクターゼ / シチジリルトランスフェラーゼ / ホスホエタノールアミン / オキシステロール Less
  • Research Projects

    (6 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (9 People)
  •  ミトコンドリアにおける新規リン脂質輸送タンパク質の破綻とミオパチー発症機構の解明Principal Investigator

    • Principal Investigator
      堀端 康博
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Dokkyo Medical University
  •  抗酸化リン脂質生合成における新規基盤と破綻による神経変性の解明Principal Investigator

    • Principal Investigator
      堀端 康博
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Dokkyo Medical University
  •  Molecular mechanism of novel phospholipid transport proteins and its relationship with mitochondrial diseasesPrincipal Investigator

    • Principal Investigator
      HORIBATA YASUHIRO
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Dokkyo Medical University
  •  Relationship between intracellular phospholipid trafficking and mitochondrial functionPrincipal Investigator

    • Principal Investigator
      Horibata Yasuhiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Dokkyo Medical University
  •  Identification of novel transcriptional factors and their roles for homeostasis of lipid composition of cell membrane

    • Principal Investigator
      Sugimoto Hiroyuki
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Dokkyo Medical University
  •  Study on a nove暮Iipid transfer protein that mediates the intraceHular trafficking of phosphoJipid to mitochondriaPrincipal Investigator

    • Principal Investigator
      HORIBATA Yasuhiro
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Dokkyo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] The ceramide transport protein CERT is involved in alkylacylglycerol transfer from the ER to the Golgi for the biosynthesis of ether phospholipid2024

    • Author(s)
      Horibata Yasuhiro、Sugimoto Hiroyuki
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 752 Pages: 109871-109871

    • DOI

      10.1016/j.abb.2023.109871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Journal Article] Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS2022

    • Author(s)
      Shinohara Y, Ando H, Maekawa M, Arai M, Horibata Y, Satou M, Jojima T, Usui I, Aso Y, Sugimoto H.
    • Journal Title

      Biochim Biopys Acta Mol Cell Biol Lipids

      Volume: 1867(6) Issue: 6 Pages: 159136-159136

    • DOI

      10.1016/j.bbalip.2022.159136

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07314, KAKENHI-PROJECT-20K07329, KAKENHI-PROJECT-21K06824, KAKENHI-PROJECT-20K08893
  • [Journal Article] Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells2022

    • Author(s)
      Shimizu Hiroaki、Horibata Yasuhiro、Amano Izuki、Ritter Megan J.、Domae Mariko、Ando Hiromi、Sugimoto Hiroyuki、Cohen Ronald N.、Hollenberg Anthony N.
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 12 Pages: e0277830-e0277830

    • DOI

      10.1371/journal.pone.0277830

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06824, KAKENHI-PROJECT-21K07347
  • [Journal Article] Metabolic changes induced by TGF-β1 via reduced expression of phosphatidylserine decarboxylase during myofibroblast transition2022

    • Author(s)
      15.Nobuhiko Uchida, Yasuo Shimizu, Mio Fujimaki, Yasuhiro Horibata, Yusuke Nakamura, Yukiko Horigane, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Seiji Niho
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 70 Issue: 2 Pages: 108-116

    • DOI

      10.3164/jcbn.21-121

    • NAID

      130008165943

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17644, KAKENHI-PROJECT-21K06824
  • [Journal Article] Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipids.2021

    • Author(s)
      Horibata, Y. and Sugimoto, H.
    • Journal Title

      J. Lipid Res.

      Volume: 62 Pages: 100100-100100

    • DOI

      10.1016/j.jlr.2021.100100

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Journal Article] Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids.2020

    • Author(s)
      Horibata Y, Ando H, Sugimoto H.
    • Journal Title

      Journal of Lipid Research

      Volume: 61 Issue: 8 Pages: 1221-1231

    • DOI

      10.1194/jlr.ra120000898

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07314, KAKENHI-PROJECT-17K08642
  • [Journal Article] The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts.2020

    • Author(s)
      Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama C, Ando H, Sugimoto H
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2845-2845

    • DOI

      10.1038/s41598-020-59444-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08642, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-20K07314
  • [Journal Article] Ethanolamine phosphotransferase 1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in human.2018

    • Author(s)
      Horibata Y, Elpeleg O, Eran A, Hirabayashi Y, Savitzki D, Tal G, Mandel H, Sugimoto H
    • Journal Title

      Journal of Lipid Research

      Volume: 59 Issue: 6 Pages: 1-12

    • DOI

      10.1194/jlr.p081620

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08284, KAKENHI-PROJECT-17K08642
  • [Journal Article] Changes of plasmalogen phospholipid levels during differentiation of induced pluripotent stem cells 409B2 to endothelial phenotype cells2017

    • Author(s)
      Yusuke Nakamura, Yasuo Shimizu, Yasuhiro Horibata, Rinna Tei, Ryosuke Koike1, Meitetsu Masawa, Taiji Watanabe, Taichi Shiobara, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Yoshiki Ishii
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-017-09980-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08284, KAKENHI-PROJECT-16K09553, KAKENHI-PROJECT-17K08642
  • [Journal Article] Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer.2017

    • Author(s)
      Horibata Y, Ando H, Satou M, Shimizu H, Mitsuhashi S, Shimizu Y, Itoh M, Sugimoto H
    • Journal Title

      Scientific Reports

      Volume: 7(1) Issue: 1 Pages: 8793-8793

    • DOI

      10.1038/s41598-017-09205-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08158, KAKENHI-PROJECT-15K08284, KAKENHI-PROJECT-17K08642
  • [Journal Article] Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 12015

    • Author(s)
      Ando H, Aoyama C, Horibata Y, Satou M, Mitsuhashi S, Itoh M, Hosaka K, Sugimoto H
    • Journal Title

      Biochemical Journal

      Volume: 471 Issue: 3 Pages: 369-379

    • DOI

      10.1042/bj20150318

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08158, KAKENHI-PROJECT-15K08284, KAKENHI-PROJECT-23590242, KAKENHI-PROJECT-24590358, KAKENHI-PROJECT-25870668
  • [Journal Article] The Structural and Functional Organization of the Podocyte Filtration Slits Is Regulated by Tjp1/ZO-1.2014

    • Author(s)
      Itoh M, Nakadate K, Horibata Y, Matsusaka T, Xu J, Hunziker W, Sugimoto H.
    • Journal Title

      PLoS One.

      Volume: 9・9 Issue: 9 Pages: e106621-e106621

    • DOI

      10.1371/journal.pone.0106621

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-23590242, KAKENHI-PROJECT-24590358, KAKENHI-PROJECT-25870668, KAKENHI-PROJECT-26460283
  • [Journal Article] Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT122013

    • Author(s)
      Horibata Y, Ando H, Itoh M, Sugimoto H.
    • Journal Title

      Journal of Lipid Research

      Volume: 54(8) Issue: 8 Pages: 2049-2059

    • DOI

      10.1194/jlr.m030163

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590242, KAKENHI-PROJECT-24590358, KAKENHI-PROJECT-25870668
  • [Journal Article] StarD7 mediates the intracellular trafficking of phosphatidylcholine tomitochondria.2010

    • Author(s)
      Horibata, Yasuhiro, Sugimoto, Hiroyuki
    • Journal Title

      Journal of Biological Chemistry. Vol.285

      Pages: 7358-7365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770091
  • [Journal Article] StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondrla.2010

    • Author(s)
      Horibata, Y., Sugimoto, H.
    • Journal Title

      J. Biol. Chem 285

      Pages: 7358-7365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770091
  • [Presentation] コリン/エタノールアミンリン脂質を新規合成する最終酵素の基質特異性とその構造基盤2023

    • Author(s)
      堀端康博, Jacquelyn Roberts, Melanie Ohi, 前田将司, 杉本博之
    • Organizer
      第96回日本生化学会
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Presentation] コリン及びエタノールアミンリン脂質合成における最終酵素CPT1、CEPT1及びEPT1の分子種特異性の検討2022

    • Author(s)
      堀端康博, 杉本博之
    • Organizer
      第95回日本生化学会
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Presentation] 新たに見出された先天性リン脂質合成酵素異常症の生化学的解析2022

    • Author(s)
      堀端康博, 杉本博之
    • Organizer
      第50回獨協医学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Presentation] CDP-コリン経路における最終酵素CPT1とCEPT1の細胞内局在とコリンリン脂質合成分子種の相違2021

    • Author(s)
      堀端康博, 杉本博之
    • Organizer
      第63回日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Presentation] CDP-エタノールアミン経路の最終酵素EPT1とCEPT1は異なるエタノールアミンリン脂質分子種の合成に寄与する2021

    • Author(s)
      堀端康博, 杉本博之
    • Organizer
      第94回日本生化学会
    • Data Source
      KAKENHI-PROJECT-21K06824
  • [Presentation] リン脂質輸送タンパク質StarD7がミトコンドリアにおいて果たす役割2020

    • Author(s)
      堀端康博, 杉本博之
    • Organizer
      第62回日本脂質生化学会プレシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] Kennedy経路における最終酵素EPT1とCEPT1の細胞内局在およびこれらの酵素が合成するエタノールアミンリン脂質分子種の相違2020

    • Author(s)
      堀端康博, 杉本博之
    • Organizer
      第62回日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] ミトコンドリアのリン脂質恒常性に関わる輸送タンパク質STARD7は骨格筋分化に必須である2019

    • Author(s)
      堀端 康博、三橋 里美、清水 裕晶、青山 智英子、杉本 博之
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] Identification, characterization, and functional analysis of a novel phospholipid carrier protein to mitochondria in mammalian cells.2019

    • Author(s)
      Horibata Yasuhiro and Sugimoto Hiroyuki
    • Organizer
      27th FAOBMB & 44th MSBMB Conference IUBMB Special Symposia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] 筋分化におけるホスファチジルコリン輸送タンパク質STARD7の役割の解析2019

    • Author(s)
      堀端 康博、三橋 里美、青山 智英子、清水 裕晶、杉本 博之
    • Organizer
      第61回日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] プラズマローゲンの保持におけるEPT1の役割とその変異による脳変性疾患2018

    • Author(s)
      堀端康博, Orly Elpeleg, 平林義雄, Hanna Mandel, 杉本博之
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] EPT1はエタノールアミンプラズマローゲンの産生と維持に主要な役割を担い、脳神経系の正常な発達を司る2018

    • Author(s)
      堀端康博, Orly Elpeleg, 平林義雄, Hanna Mandel, 杉本博之
    • Organizer
      第60回日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] ホスファチジルコリン輸送タンパク質StarD7は、ミトコンドリア外膜の外葉に局在する2017

    • Author(s)
      堀端康博, 安戸博美, 佐藤元康, 清水裕晶, 三橋里美, 清水泰生, 伊藤雅彦, 杉本博之
    • Organizer
      第90回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] StarD7が有する膜貫通領域の同定とミトコンドリア局在およびPC輸送における役割2017

    • Author(s)
      堀端康博, 安戸博美, 青山智英子, 佐藤元康, 清水泰生, 伊藤雅彦, 杉本博之
    • Organizer
      第59回日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-17K08642
  • [Presentation] StarD7によるミトコンドリアのホスファチジルコリン組成および機能と形態形成の維持2016

    • Author(s)
      堀端康博、伊藤雅彦、Peixiang Zhang、 Laurent Vergnes、安戸博美、青山智恵子、Karen, Reue、杉本博之
    • Organizer
      第58回日本脂質生化学会
    • Place of Presentation
      秋田
    • Year and Date
      2016-06-09
    • Data Source
      KAKENHI-PROJECT-25870668
  • [Presentation] Oxysterol delivertives and transcriptional factors regulating phosphatidylethanolamine and cholesterol biosynthesis2015

    • Author(s)
      Hiromi Ando, Chieko Aoyama, Yasuhiro Horibata, Motoyasu Satou, Masahiko Itoh, Hiroyuki Sugimoto
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会・合同会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-24590358
  • [Presentation] 膵臓β細胞株βTC3を用いたスタチンによる糖尿病発症機序の解明2015

    • Author(s)
      堀端康博、Peixiang Zhang、Karen Reue
    • Organizer
      第38回分子生物学会年会/第88回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25870668
  • [Presentation] ホスファチジルエタノールアミン合成を制御するオキシステロール代謝産物と転写因子の同定2013

    • Author(s)
      安戸博美、青山智英子、山下智子、堀端康博、佐藤元康、三橋里美、杉本博之
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24590358
  • [Presentation] 脂質生合成を制御する細胞質アセチルCoA分解酵素Acyl-CoAチオエステラーゼ12(ACOT12)の活性調節機構の解析2013

    • Author(s)
      堀端康博、安戸博美、伊藤雅彦、杉本博之
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24590358
  • [Presentation] 脂質生合成を制御する細胞質アセチルCoA分解酵素Acyl-CoAチオエステラーゼ12(ACOT12)の活性調節機構の解析2013

    • Author(s)
      堀端康博、安戸博美、伊藤雅彦、杉本博之
    • Organizer
      第86回日本生化学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25870668
  • [Presentation] ミトコンドリア恒常性維持における新規リン脂質輸送分子の役割2013

    • Author(s)
      堀端康博
    • Organizer
      第41回獨協医学会
    • Place of Presentation
      栃木
    • Data Source
      KAKENHI-PROJECT-25870668
  • [Presentation] リン脂質をミトコンドリア-輸送する新規タンパク質の機能解明2009

    • Author(s)
      堀端康博
    • Organizer
      第3 7回濁協医学会
    • Place of Presentation
      栃木
    • Data Source
      KAKENHI-PROJECT-20770091
  • [Presentation] リン脂質をミトコンドリアへ輸送する新規タンパク質の機能解明2009

    • Author(s)
      堀端康博
    • Organizer
      第37回獨協医学会
    • Place of Presentation
      栃木
    • Year and Date
      2009-12-05
    • Data Source
      KAKENHI-PROJECT-20770091
  • [Presentation] リン脂質輸送タンパク質StarD7の生化学的解析と細胞内局在2008

    • Author(s)
      堀端康博
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      徳島
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-20770091
  • [Presentation] リン脂質輸送タンパク質starD7の生化学的解析と細胞内局在2008

    • Author(s)
      堀端康博、杉本博之
    • Organizer
      第50回日本脂質生化学会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-20770091
  • [Presentation] Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase and HMG-CoA reductase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang1.

    • Author(s)
      Ando H, Aoyama C, Horibata Y, Sugimoto H.
    • Organizer
      Deuel Conference on Lipids
    • Place of Presentation
      Monterey, California
    • Year and Date
      2015-03-03 – 2015-03-06
    • Data Source
      KAKENHI-PROJECT-24590358
  • [Presentation] Regulatory systems of acyl-CoA thioesterase 12 (ACOT12) that control cytosolic acetyl-CoA degradation and the lipid biosynthesis.

    • Author(s)
      Horibata Y, Ando H, Itoh M, Sugimoto H.
    • Organizer
      Deuel Conference on Lipids
    • Place of Presentation
      Monterey, California
    • Year and Date
      2015-03-03 – 2015-03-06
    • Data Source
      KAKENHI-PROJECT-24590358
  • 1.  Sugimoto Hiroyuki (00235897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 2.  AOYAMA Chieko (90420778)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  SATOU Motoyasu (20418891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  ANDO Hiromi (10704885)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 5.  Reue Karen
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  Zhang Peixiang
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  Vergnes Laurent
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  伊藤 雅彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  松阪 泰二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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