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NAKAYAMA-MUGURUMA YUKARI  中山 ゆかり

ORCIDConnect your ORCID iD *help
… Alternative Names

六車ゆかり

中山 ゆかり(六車ゆかり)  ナカヤマ ユカリ

中山 ゆかり  ナカヤマ ユカリ

MUGURUMA Yukari  六車 ゆかり

NAKAYAMA Yukari  中山 ゆかり

六車 ゆかり  ムグルマ ユカリ

Less
Researcher Number 80398750
Affiliation (based on the past Project Information) *help 2013 – 2016: 東海大学, 医学部, 助教
2010 – 2012: Tokai University, 医学部, 特定研究員
2008 – 2010: Tokai University, 医学部, 研究員
2006: 東海大学, 医学部, 特定研究員
Review Section/Research Field
Principal Investigator
Laboratory animal science / Laboratory animal science / General medical chemistry
Except Principal Investigator
General medical chemistry
Keywords
Principal Investigator
Notch / 骨芽細胞 / 骨代謝 / niche / cell cycle / cord blood / intra-bone marrow transplantation / mesehcnymal stem cells / humanized mouse / hematopoietic stern cells … More / 造血制御 / 造血環境 / ヒトビモデンレマウス / 細胞周期 / 臍帯血 / 骨髄内移植 / 間葉系幹細胞 / ヒト化モデルマウス / ニッチ / 造血幹細胞 / Delta-like 1 / リモデリング / Delta-like1 / Jagged1 / リガンド特異性 / Notchシグナル / 骨髄微小環境 / 多発性骨髄腫 / microenvironment / xenograft / humanized mice / multiple myeloma / 破骨細胞 / 造骨細胞 / 造血代謝 / 造血恒常性 / 骨と骨髄 / 再生医学 … More
Except Principal Investigator
間系幹細胞 / 細胞周期 / 再生医療 / 骨髄移植 / 間葉系幹細胞 / ヒト化モデルマウス / クローン解析 / ニッチ / 造血幹細胞 Less
  • Research Projects

    (5 results)
  • Research Products

    (47 results)
  • Co-Researchers

    (6 People)
  •  Maintenance of bone homeostasis by DLL1-mediated Notch activationPrincipal Investigator

    • Principal Investigator
      NAKAYAMA-MUGURUMA YUKARI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokai University
  •  Analysis of Multiple myeloma pahtophysiology using xenograft model having humanized BM microenvironmentPrincipal Investigator

    • Principal Investigator
      MUGURUMA Yukari
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokai University
  •  Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasisPrincipal Investigator

    • Principal Investigator
      NAKAYAMA Yukari
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokai University
  •  Analysis of repopulating dynamics of human hematopoietic stem cells

    • Principal Investigator
      YAHATA Takashi
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokai University
  •  Establishment of human hematopoietic system model mouse for understanding the regulatory mechanisms of human hematopoiesis.Principal Investigator

    • Principal Investigator
      YAHATA Takashi, 中山 ゆかり (六車 ゆかり)
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokai University

All 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

  • [Journal Article] Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling.2017

    • Author(s)
      Muguruma Y, Hozumi K, Warita H, Yahata T, Uno T, Ito M, Ando K.
    • Journal Title

      J Cell Physiol.

      Volume: 印刷中 Issue: 9 Pages: 2569-2580

    • DOI

      10.1002/jcp.25647

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-26430094, KAKENHI-PROJECT-17H03572
  • [Journal Article] Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice2014

    • Author(s)
      Matsushita, H. Yahata, T. Sheng, Y. Nakamura, Y. Muguruma, Y. Matsuzawa, H. Tanaka, M. Hayashi, H. Sato, T. Damdinsuren, A. Onizuka, M. Ito, M. Miyachi, H. Pandolfi, P. P. Ando, K.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e111082-e111082

    • DOI

      10.1371/journal.pone.0111082

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-24591411, KAKENHI-PROJECT-26430094
  • [Journal Article] Establishment of a xenograft model of human myelodysplastic syndromes.2011

    • Author(s)
      Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
    • Journal Title

      Haematologica. 96(4)

      Pages: 543-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Journal Article] Establishment of a xenograft model of human myelodysplastic syndromes2011

    • Author(s)
      Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
    • Journal Title

      Haematologica

      Volume: 96(4) Pages: 543-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011

    • Author(s)
      Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
    • Journal Title

      Blood

      Volume: 118(11) Pages: 2941-50

    • NAID

      40019489714

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011

    • Author(s)
      Yahata, T.
    • Journal Title

      Blood

      Volume: 118 Issue: 11 Pages: 2941-2950

    • DOI

      10.1182/blood-2011-01-330050

    • NAID

      40019489714

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22790299, KAKENHI-PROJECT-23500501
  • [Journal Article] Establishment of xenograft model of human myelodysplastic syndromes2011

    • Author(s)
      Muguruma Y, Matsushita H, Yahata H, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
    • Journal Title

      Haematologica

      Volume: 96 Issue: 4 Pages: 543-551

    • DOI

      10.3324/haematol.2010.027557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591224, KAKENHI-PROJECT-22790299, KAKENHI-PROJECT-23500501
  • [Journal Article] Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo : advantages over bone marrow-derived mesenchymal stem cells.2010

    • Author(s)
      Nakao N, Nakayama T, Yahata T, Muguruma Y, Saito S, Miyata Y, Yamamoto K, Naoe T.
    • Journal Title

      Am J Pathol. 177(2)

      Pages: 547-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Journal Article] FACSを用いたヒト造血幹細胞の生体内における性状解析2009

    • Author(s)
      八幡崇、六車ゆかり、安藤潔
    • Journal Title

      Cytometry Research 19(2)

      Pages: 19-23

    • NAID

      10026084405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008

    • Author(s)
      Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K.
    • Journal Title

      Stem Cells. 26(12)

      Pages: 3228-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Journal Article] Humanizing bone marrow in immune-deficient mice.2008

    • Author(s)
      Ando K, Muguruma Y, Yahata T
    • Journal Title

      Curr Top Microbiol Immunol. 324(Review)

      Pages: 77-86

    • Data Source
      KAKENHI-PROJECT-20590289
  • [Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008

    • Author(s)
      Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K.
    • Journal Title

      Stem Cells. 26(12)

      Pages: 3228-3236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Journal Article] Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment2006

    • Author(s)
      Muguruma, Y et al.
    • Journal Title

      Blood 107・5

      Pages: 1878-1887

    • Data Source
      KAKENHI-PROJECT-18500332
  • [Journal Article] Adipocyte-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo: advantages over bone marrow-derived mesenchymal stem cells.

    • Author(s)
      Nakao N, Nakayama T, Yahata T, Muguruma Y, Miyata Y, Naoe T.
    • Journal Title

      Am J Pathol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Journal Article] Establishment of xenograft model of human myelodysplastic syndromes.

    • Author(s)
      Muguruma Y., et al.
    • Journal Title

      Haematologica

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Jagged1-Notch interaction in the niche is responsible for acquisition of drug-resistance2016

    • Author(s)
      Muguruma Y, Hozumi K, Warita H, Yahata T, Uno T, Ito M, Ando K
    • Organizer
      日本血液学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-14
    • Data Source
      KAKENHI-PROJECT-26430094
  • [Presentation] Intracellular PAI1 is a critical regulator of stem cell localization in the niche2016

    • Author(s)
      Takashi Yahata, Abd Aziz Ibrahim, Yukari Muguruma, Toshio Miyata, Kiyosi Ando
    • Organizer
      Gordon Conference
    • Place of Presentation
      Four Points Sheraton (CA, USA)
    • Year and Date
      2016-02-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430094
  • [Presentation] Identification of molecular interactions in MM nich in vivo2015

    • Author(s)
      Yukari Muguruma, Takashi Yahata, Takayuki Warita, Yoshihiko Nakamura, Rikio Suzuki, Shumpei Ishikawa, Takayuki Isagawa,Kiyoshi Ando
    • Organizer
      日本血液学会
    • Place of Presentation
      ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-26430094
  • [Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012

    • Author(s)
      Takashi Yahata, Tomoni Takanashi, Yukari Muguruma, Abd Aziz Ibrahim, Hiedyuki Matsuzawa, Tomoko Uno, Yin Sheng, Makoto Onizuka, Mamoru Ito, Shyunichi Kato, Kiyoshi Ando
    • Organizer
      日本血液学会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2012

    • Author(s)
      Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Ando K
    • Organizer
      JSH International Symposium
    • Place of Presentation
      川越プリンスホテル
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012

    • Author(s)
      Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
    • Organizer
      第74回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Presentation] CD34+/CD38+ cells from human cord blood onotoate APL by induction of PML-RARA2012

    • Author(s)
      Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, et al.
    • Organizer
      JSH International Symposium
    • Place of Presentation
      Kawagoe Prince Hotel
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2011

    • Author(s)
      Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Ando K
    • Organizer
      第73回日本血液学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010

    • Author(s)
      六車ゆかり
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010

    • Author(s)
      六車ゆかり、八幡崇、弓野静、盛音、穂積勝人、安藤潔
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010

    • Author(s)
      六車ゆかり、八幡崇、穂積勝人、安藤潔
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 造血幹細胞制御におけるNotchシグナルの役割2010

    • Author(s)
      六車ゆかり
    • Organizer
      第10回血液フォーラム21
    • Place of Presentation
      東京
    • Year and Date
      2010-03-06
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010

    • Author(s)
      六車ゆかり
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis.2009

    • Author(s)
      Muguruma Y, Yahata T, Yumino S, et al.
    • Organizer
      The 26th Naito Conference on Osteobiology
    • Place of Presentation
      Awaji, Japan
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signals in maintaining hematopoietic homeostasis.2009

    • Author(s)
      六車ゆかり、八幡崇
    • Organizer
      内藤カンファレンスosteobiology
    • Place of Presentation
      夢舞台(淡路)
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis2009

    • Author(s)
      六車ゆかり
    • Organizer
      Stem Cell Conference
    • Place of Presentation
      泉ガーデン(東京)
    • Year and Date
      2009-05-16
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis2009

    • Author(s)
      六車ゆかり、八幡崇
    • Organizer
      日本血液学会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009

    • Author(s)
      八幡崇、高梨朋美、盛音、宇野トモ子、六車ゆかり, 他
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009

    • Author(s)
      八幡崇, 六車ゆかり
    • Organizer
      日本血液学会
    • Place of Presentation
      国際会議場(京都)
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis.2009

    • Author(s)
      Muguruma Y, Yahata T, Sheng Y, et al.
    • Organizer
      The 7th Stem Cell Research Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signaling in maintaining hematopoietic homeostasis.2009

    • Author(s)
      Muguruma Y, Yahata Y, Sheng Y, et al.
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signals in maintaining hematopoietic homeostasis.2009

    • Author(s)
      六車ゆかり
    • Organizer
      内藤カンファレンスosteobiology
    • Place of Presentation
      夢舞台(淡路)
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Importance of Notch signals in hematopoietic homeostasis2009

    • Author(s)
      六車ゆかり
    • Organizer
      日本血液学会
    • Place of Presentation
      国際会議場(京都)
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 骨髄異形成症候群in vivoモデルの確立2008

    • Author(s)
      六車 ゆかり, 他
    • Organizer
      日本血液学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2008-10-11
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 骨髄造血微小環境の恒常性維持におけるJagged1分子の重要性2008

    • Author(s)
      六車 ゆかり, 他
    • Organizer
      日本血液学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-10-11
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Presentation] 骨髄異形成症候群のin vivoモデルの確立2008

    • Author(s)
      六車ゆかり、他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Data Source
      KAKENHI-PROJECT-20790238
  • [Presentation] 骨髄異形成症候群in vivoモデルの確立2008

    • Author(s)
      六車ゆかり, 他
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 骨髄造血微小環境の恒常性維持におけるJagged-1分子の重要性2008

    • Author(s)
      八幡崇、六車ゆかり, 他
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] In vivo model for human red blood cell maturation analysis2007

    • Author(s)
      Muguruma, Y, et. al.
    • Organizer
      Japanese Society of Hematology Meeting
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500332
  • [Presentation] In Vivo Analysis of PML-RARA in a Humanized Mouse Model

    • Author(s)
      Hiromichi Matsushita, Takashi Yahata,, Yin Sheng, Yoshihiko Nakamura, Yukari Muguruma, Hideyuki Matsuzawa, Masayuki Tanaka, Hideki Hayashi, Tadayuki Sato, Anar Damdinsuren, Makoto Onizuka, Mamoru Ito, Hayato Miyachi,, Pier Paolo Pandolfi, Kiyoshi Ando
    • Organizer
      America Society of Hematology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-26430094
  • [Presentation] CD34+/CD38+cells from human cord blood initiate APL by induction of PML-RARA

    • Author(s)
      Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, Hideyuki MAtsuzawa, Tomoko Uno, Tomomi Takanashi, Kiyoshi Ando
    • Organizer
      日本血液学会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23500501
  • [Presentation] Jagged1-Notch signal supports human myeloma cell survival

    • Author(s)
      Yukari Muguruma, Takashi Yahata, Mamoru Itoh, Katsuto Hozumi, Mika Yamaguchi, Kiyoshi Ando
    • Organizer
      日本血液学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-26430094
  • 1.  YAHATA Takashi (10398753)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 34 results
  • 2.  ANDO Kiyoshi (70176014)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 22 results
  • 3.  HOZUMI Katsuto (30246079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  ITO Ryoji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  伊藤 守
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  松下 弘道
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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