INUI Naoki 乾直輝

… Alternative Names

Inui Naoki 乾直輝

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Researcher Number	80402254
Other IDs
Affiliation (Current)	2025: 浜松医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 浜松医科大学, 医学部, 教授 2014 – 2019: 浜松医科大学, 医学部, 准教授 2008 – 2012: Hamamatsu University School of Medicine, 医学部, 助教 2010: Hamamatsu University School of Medicine, 医学部・臨床薬理学, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Applied pharmacology Except Principal Investigator Medical pharmacy / Basic Section 53030:Respiratory medicine-related / Basic Section 47060:Clinical pharmacy-related / Applied pharmacology
Keywords	Principal Investigator ブレオマイシン / 線維化 / 肺線維化 / 肺線維症 / 血管内皮細胞 / 繊維化 / 間質性肺炎 / 抗癌剤S1 / CYP2A6 / 肺癌 … More / 抗癌剤S-1 / 個別化治療 / 薬物代謝酵素 / 薬物治療学 … More Except Principal Investigator 臨床試験 / 薬物相互作用 / PAI-1 / 慢性閉塞性肺疾患（COPD） / 動脈硬化 / 肺気腫 / COPD / 服用性 / がん / 口内炎 / 製剤学的評価 / 院内製剤 / 口腔粘膜炎 / フォーム製剤 / シトクロムP450 / カクテル試験 / 近赤外線時間分解分光法 / 反応性充血 / 血管内皮機能 / 降圧薬 / 健康食品 / 血漿中濃度 / カルシウム拮抗薬 / グレープフルーツジュース / 臨床効果 / 相互作用 / 臨床薬学 Less

Novel therapeutic strategies for COPD targeting the fibrinolysis inhibitor PAI-1
- Principal Investigator
  
  安井秀樹
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hamamatsu University School of Medicine
線維化解除をターゲットとした肺線維化病態の解明と創薬への展開Principal Investigator
- Principal Investigator
  
  乾直輝
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hamamatsu University School of Medicine
Preparation and clinical evaluation of foam formulations for the treatment of oral mucositis.
- Principal Investigator
  
  Uchida Shinya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Hypoxia on Pulmonary Endothelial Cells from Bleomycin-Induced Fibrosis MicePrincipal Investigator
- Principal Investigator
  
  Inui Naoki
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hamamatsu University School of Medicine
Changes in pulmonary endothelial cell and fibroblast properties during bleomycin-induced pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  Inui Naoki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hamamatsu University School of Medicine
Development and validation of the cocktail study for the method in detection of drug-drug interactions
- Principal Investigator
  
  UCHIDA shinya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological tool
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers
- Principal Investigator
  
  UCHIDA Shinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
The usefulness of chemotherapy with S-1 for Japanese patients with non-small-cell lung cancer based on CYP2A6*4 gene polymorphismPrincipal Investigator
- Principal Investigator
  
  INUI Naoki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine

[Journal Article] Prevalence and clinical features of progressive pulmonary fibrosis in patients with unclassifiable idiopathic interstitial pneumonia: A post hoc analysis of prospective multicenter registry2025
- Author(s)
  Kono Masato、Enomoto Noriyuki、Inoue Yusuke, Suda Takafumi
- Journal Title
  
  Respiratory Investigation
  
  Volume: 63 Issue: 2 Pages: 216-223
- DOI
  10.1016/j.resinv.2025.01.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02456, KAKENHI-PROJECT-23K07598
[Journal Article] Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts2025
- Author(s)
  Fukada Atsuki、Enomoto Yasunori、Horiguchi Ryo、Aoshima Yoichiro、Meguro Shiori、Kawasaki Hideya、Kosugi Isao、Fujisawa Tomoyuki、Enomoto Noriyuki、Inui Naoki、Suda Takafumi、Iwashita Toshihide
- Journal Title
  
  Respiratory Research
  
  Volume: 26 Issue: 1 Pages: 14-14
- DOI
  10.1186/s12931-025-03103-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07390, KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-21K07816, KAKENHI-PROJECT-24K02249, KAKENHI-PROJECT-23K07598, KAKENHI-PROJECT-24K11361
[Journal Article] Need for reassessment of the diagnosis of interstitial lung disease using a multidisciplinary discussion approach2025
- Author(s)
  Inui Naoki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 63 Issue: 1 Pages: 33-34
- DOI
  10.1016/j.resinv.2024.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08539
[Journal Article] The role of arterial stiffness as assessed by the cardio-ankle vascular index in patients with chronic obstructive pulmonary disease2025
- Author(s)
  Oishi K, Yasui H, Inoue Y, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Suda T.
- Journal Title
  
  Respir Med.
  
  Volume: 241 Pages: 108078-108078
- DOI
  10.1016/j.rmed.2025.108078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K11340
[Journal Article] Antifibrotics and mortality in idiopathic pulmonary fibrosis: external validity and avoidance of immortal time bias2024
- Author(s)
  Hozumi Hironao、Miyashita Koichi、Nakatani Eiji、Inoue Yusuke、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Suda Takafumi
- Journal Title
  
  Respiratory Research
  
  Volume: 25 Issue: 1
- DOI
  10.1186/s12931-024-02922-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-24K11312
[Journal Article] Neutrophil-lymphocyte ratio being associated with mortality risk in patients receiving antifibrotic therapy2024
- Author(s)
  Takuma Sho、Suzuki Yuzo、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Mori Kazutaka、Shimizu Mikihiro、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Suda Takafumi
- Journal Title
  
  Respiratory Medicine
  
  Volume: 223 Pages: 107542-107542
- DOI
  10.1016/j.rmed.2024.107542
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08279, KAKENHI-PROJECT-23K07598, KAKENHI-PROJECT-21K08176
[Journal Article] CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling2024
- Author(s)
  Naoi Hyogo、Suzuki Yuzo、Miyagi Asuka、Horiguchi Ryo、Aono Yuya、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Mii Shinji、Ichihara Masatoshi、Takahashi Masahide、Suda Takafumi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 212 Issue: 7 Pages: 1221-1231
- DOI
  10.4049/jimmunol.2300285
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08279, KAKENHI-PROJECT-23K08306, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-22K07000, KAKENHI-PROJECT-23K07598, KAKENHI-PROJECT-24K11312
[Journal Article] Impact of preexisting interstitial lung disease on mortality in COVID-19 patients from the early pandemic to the delta variant epidemic: a nationwide population-based study2024
- Author(s)
  Miyashita Koichi、Hozumi Hironao、Furuhashi Kazuki、Nakatani Eiji、Inoue Yusuke、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Ojima Toshiyuki、Suda Takafumi
- Journal Title
  
  Respiratory Research
  
  Volume: 25 Issue: 1 Pages: 95-95
- DOI
  10.1186/s12931-024-02723-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-21K08176
[Journal Article] CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study2024
- Author(s)
  Enomoto N、Nakai S、Yazawa S、Mochizuka Y、Fukada A、Tanaka Y、Naoi H、Inoue Y、Yasui H、Karayama M、Suzuki Y、Hozumi H、Furuhashi K、Toyoshima M、Kono M、Imokawa S、Fujii M、Akamatsu T、Koshimizu N、Yokomura K、Matsuda H、Kaida Y、Nakamura Y、Shirai M、Mori K、Masuda M、Fujisawa T、Inui N、Sugiura H
- Journal Title
  
  Respiratory Research
  
  Volume: 25 Issue: 1
- DOI
  10.1186/s12931-024-02982-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07598
[Journal Article] A predictive model for acute exacerbation of idiopathic interstitial pneumonias2023
- Author(s)
  Karayama Masato、Aoshima Yoichiro、Suzuki Takahito、Mori Kazutaka、Yoshizawa Nobuko、Ichikawa Shintaro、Kato Shinpei、Yokomura Koshi、Kono Masato、Hashimoto Dai、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Goshima Satoshi、Inui Naoki、Suda Takafumi
- Journal Title
  
  European Respiratory Journal
  
  Volume: 61 Issue: 5 Pages: 2201634-2201634
- DOI
  10.1183/13993003.01634-2022
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07388, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-23K07598, KAKENHI-PROJECT-20K08539
[Journal Article] Geriatric Nutritional Risk Index is a predictor of tolerability of antifibrotic therapy and mortality risk in patients with idiopathic pulmonary fibrosis2023
- Author(s)
  Mochizuka Yasutaka、Suzuki Yuzo、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Hidenori、Suda Takafumi
- Journal Title
  
  Respirology
  
  Volume: 28 Issue: 8 Pages: 775-783
- DOI
  10.1111/resp.14523
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-22K08279, KAKENHI-PROJECT-23K07598, KAKENHI-PROJECT-21K08176
[Journal Article] Neutrophil?lymphocyte ratio in patients with idiopathic pleuroparenchymal fibroelastosis2023
- Author(s)
  Suzuki Yuzo、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Imokawa Shiro、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Suda Takafumi
- Journal Title
  
  BMJ Open Respiratory Research
  
  Volume: 10 Issue: 1 Pages: e001763-e001763
- DOI
  10.1136/bmjresp-2023-001763
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-22K08279, KAKENHI-PROJECT-21K08176
[Journal Article] CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation2023
- Author(s)
  Aono Yuya、Suzuki Yuzo、Horiguchi Ryo、Inoue Yusuke、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Mii Shinji、Takahashi Masahide、Suda Takafumi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 68 Issue: 2 Pages: 201-212
- DOI
  10.1165/rcmb.2022-0109oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-22K07000, KAKENHI-PROJECT-22K08279, KAKENHI-PROJECT-19K17671
[Journal Article] Effect of Hypoxia on Pulmonary Endothelial Cells from Bleomycin-Induced Pulmonary Fibrosis Model Mice2022
- Author(s)
  Akahori Daisuke、Inui Naoki、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Suda Takafumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 16 Pages: 8996-8996
- DOI
  10.3390/ijms23168996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-20K08539
[Journal Article] Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: mortality and its prediction model2022
- Author(s)
  Hozumi Hironao、Kono Masato、Hasegawa Hirotsugu、Kato Shinpei、Inoue Yusuke、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
- Journal Title
  
  Respiratory Research
  
  Volume: 23 Issue: 1 Pages: 57-57
- DOI
  10.1186/s12931-022-01978-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08623, KAKENHI-PROJECT-19K17632, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-20K08539
[Journal Article] Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma2022
- Author(s)
  Suzuki Yuzo、Aono Yuya、Akiyama Norimichi、Horiike Yasuoki、Naoi Hyogo、Horiguchi Ryo、Shibata Kiyoshi、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
- Journal Title
  
  Autophagy
  
  Volume: － Issue: 9 Pages: 1-13
- DOI
  10.1080/15548627.2022.2025571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17632, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-19K17671
[Journal Article] Impact of antifibrotic therapy on lung cancer development in idiopathic pulmonary fibrosis2022
- Author(s)
  Naoi Hyogo、Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
- Journal Title
  
  Thorax
  
  Volume: in press Issue: 7 Pages: 1-1
- DOI
  10.1136/thoraxjnl-2021-218281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17632, KAKENHI-PROJECT-21K07388, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-20K08539
[Journal Article] Idiopathic pleuroparenchymal fibroelastosis: three-dimensional computed tomography assessment of upper-lobe lung volume2022
- Author(s)
  Fukada Atsuki、Suzuki Yuzo、Mori Kazutaka、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Imokawa Shiro、Tanaka Yuko、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Fujino Yoshihisa、Nakamura Hidenori、Suda Takafumi
- Journal Title
  
  European Respiratory Journal
  
  Volume: 60 Issue: 6 Pages: 2200637-2200637
- DOI
  10.1183/13993003.00637-2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08539, KAKENHI-PROJECT-21K07388, KAKENHI-PROJECT-21K08176, KAKENHI-PROJECT-22K08279
[Journal Article] Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway2021
- Author(s)
  Inui, N., Sakai, S., Kitagawa, M
- Journal Title
  
  Int. J. Mol. Sci
  
  Volume: 22 Issue: 11 Pages: 6107-6107
- DOI
  10.3390/ijms22116107
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-20K08539
[Journal Article] CD248 and integrin alpha-8 are candidate markers for differentiating lung fibroblast subtypes2020
- Author(s)
  Matsushima Sayomi、Aoshima Yoichiro、Akamatsu Taisuke、Enomoto Yasunori、Meguro Shiori、Kosugi Isao、Kawasaki Hideya、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Funai Kazuhito、Suda Takafumi、Iwashita Toshihide
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 20 Issue: 1 Pages: 1-1
- DOI
  10.1186/s12890-020-1054-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08784, KAKENHI-PROJECT-17K09609, KAKENHI-PROJECT-18H02818
[Journal Article] Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary fibrosis.2019
- Author(s)
  Akiyama N, Hozumi H, Isayama T, Okada J, Sugiura K, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
- Journal Title
  
  Respirology
  
  Volume: 0 Issue: 7 Pages: 0-0
- DOI
  10.1111/resp.13707
- NAID
  120007097006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09609, KAKENHI-PROJECT-18K15947, KAKENHI-PROJECT-19K17632, KAKENHI-PROJECT-18H02818
[Journal Article] Changes in pulmonary endothelial cell properties during bleomycin-induced pulmonary fibrosis.2018
- Author(s)
  Kato S, Inui N*, Hakamata A, Suzuki Y, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
- Journal Title
  
  Respir Res.
  
  Volume: 19 Issue: 1 Pages: 127-127
- DOI
  10.1186/s12931-018-0831-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09609, KAKENHI-PROJECT-16K19448
[Journal Article] カクテル試験を用いた薬物相互作用の網羅的解析法の確立と応用2014
- Author(s)
  田中紫茉子、内田信也、乾直輝、渡邉裕司、並木徳之
- Journal Title
  
  PROGRESS IN DRUG DELIVERY SYSTEM
  
  Volume: XXIII Pages: 21-26
- Data Source
  KAKENHI-PROJECT-26460202
[Journal Article] Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam : an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers2011
- Author(s)
  Shingen Misaka, Reiko Nakamura, Shinya Uchida, Kazuhiko Takeuchi, Norio Takahashi, Naoki Inui, Kazuhiro Kosuge, Shizuo Yamada, Hiroshi Watanabe
- Journal Title
  
  Clin. Ther
  
  Volume: 33 Pages: 246-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590171
[Journal Article] Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes2010
- Author(s)
  Shinya Uchida, Kayoko Shimada, Shingen Misaka, Hiromitu Imai, Yasuhiro Katoh, Naoki Inui, Kazuhiko Takeuchi, Takashi Ishizaki, Shizuo Yamada, Kyoichi Ohashi, Noriyuki Namiki, Hiroshi Watanabe
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 605-610
- NAID
  10027743998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590171
[Journal Article] Pharmacokinetics and pharmacodynamics of midazolam administered intravenously and orally at low doses to healthy volunteers2010
- Author(s)
  Shingen Misaka, Shinya Uchida, Hiromitsu Imai, Naoki Inui, Shinichiro Nishio, Kyoichi Ohashi, Hiroshi Watanabe, Shizuo Yamada
- Journal Title
  
  Clin. Exp. Pharmacol. Physiol
  
  Volume: 37 Pages: 290-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590171
[Journal Article] Phase II study of combination chemotherapy with S-1 and weekly cisplatin in patients with previously untreated advanced non-small cell lung cancer.2009
- Author(s)
  Ozawa Y, Inui N, Naitoh T, Yasuda K, Nagayama M, Shirai T, Suganuma H, Fujii M, Nakamura H, Suda T, Chida K.
- Journal Title
  
  Lung Cancer. 63
  
  Pages: 68-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] Effects of statins on the pharmacokinetics of midazolam in healthy volunteers.2009
- Author(s)
  Kokudai M, Inui N, Takeuchi K, Sakaeda T, Kagawa Y, Watanabe H.
- Journal Title
  
  J Clin Pharmacol. 49
  
  Pages: 568-573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] Effect of thyroid hormone on the activity of CYP3A enzyme in humans.2009
- Author(s)
  Takahashi N, Inui N, Morita H, Takeuchi K, Uchida S, Watanabe H, Nakamura H.
- Journal Title
  
  J Clin Pharmacol. 50
  
  Pages: 88-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer2008
- Author(s)
  Kaida Y, Inui N, Suda T, Nakamura H, Watanabe H, Chida K
- Journal Title
  
  Clin Pharmacol Ther 83
  
  Pages: 589-594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] 非小細胞肺癌患者における薬物代謝酵素CYP2A6遺伝子多型の存在とS-1の薬物動態に及ぼす影響2008
- Author(s)
  貝田勇介, 乾直輝, 渡邉裕司
- Journal Title
  
  臨床薬理の進歩 29
  
  Pages: 81-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] Response to "The Unanswered Question : What Is the Determinant of S-1 Pharmacokinetics?2008
- Author(s)
  Kaida Y, Inui N, Suda T, Watanabe H, Chida K.
- Journal Title
  
  Clin Pharmacol Ther 84
  
  Pages: 204-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Presentation] CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling2024
- Author(s)
  Naoi H, Suzuki Y, Miyagi A, Horiguchi R, Aono Y, Inoue Y, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Mii S, Ichihara M, Takahashi M, Suda T
- Organizer
  American Thoracic Society 2024 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08539
[Presentation] Prevalence and Clinical Significance of Pulmonary Progressive Fibrosis in Myositis-associated Interstitial Lung Disease.2024
- Author(s)
  Fujisawa T, Kitahara Y, Fukada A, Inoue Y, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Inui N, Suda T, and Hamamatsu PMDM-ILD study group
- Organizer
  American Thoracic Society 2024 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08539
[Presentation] サルコイドーシスの診断基準について―本邦におけるこれまでの変遷と海外の状況ー2024
- Author(s)
  乾直輝
- Organizer
  第123回　日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08539
[Presentation] Clinical Utility of Serum S100 Calcium Binding Protein A4 in Idiopathic Pulmonary Fibrosis2019
- Author(s)
  Akiyama N, Hozumi H, Yasui H, Kono M, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T
- Organizer
  American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09609
[Presentation] ブレオマイシン誘発性肺線維症モデルマウスにおける肺血管内皮細胞の変化2019
- Author(s)
  加藤慎平、乾直輝、袴田晃央、鈴木勇三、榎本紀之、藤澤朋幸、中村祐太郎、渡邊裕司、須田隆文
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09609
[Presentation] カクテル試験の薬物相互作用検出法としての妥当性の検証2017
- Author(s)
  野神優月、田中紫茉子、内田信也、篠原美紀、三浦基靖、袴田晃央、小田切圭一、乾直輝、渡邉裕司、並木徳之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] カクテル試験での1ポイント採血における血漿中濃度及び尿中代謝比とAUCとの関係―caffeine、losartan及びomeprazoleにおける検討―2016
- Author(s)
  4.篠原美紀、芝切若奈、内田信也、田中紫茉子、袴田晃央、小田切圭一、乾直輝、渡邉裕司、並木徳之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] カクテル試験での1ポイント採血における血漿中濃度および尿中代謝比とAUCとの関係―dextromethorphanおよびmidazolamにおける検討―2016
- Author(s)
  5.芝切若奈、篠原美紀、内田信也、田中紫茉子、袴田晃央、小田切圭一、乾直輝、渡邉裕司、並木徳之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] CYP1A2, CYP2C9, 2C19, 2D6および3Aの基質薬の血中濃度と, 薬物による誘導・阻害の影響の関連性2015
- Author(s)
  2.小田切圭一、袴田晃央、片山直紀、宮川幸子、乾直輝、田中紫茉子、内田信也、並木徳之、渡邉裕司
- Organizer
  第36回日本臨床薬理学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] カクテル試験における基質薬物の血漿中濃度とAUCとの相関性2015
- Author(s)
  3.田中紫茉子、浜咲理子、乾直輝、渡邉裕司、内田信也、並木徳之
- Organizer
  第36回日本臨床薬理学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] シトクロムP450酵素誘導の経時的変化2014
- Author(s)
  乾直輝、内田信也、渡邉裕司
- Organizer
  第35回日本薬理学会学術総会
- Place of Presentation
  松山
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] カクテル試験を用いた薬物相互作用の網羅的解析法の確立と応用2014
- Author(s)
  田中紫茉子、内田信也、乾直輝、渡邉裕司、並木徳之
- Organizer
  第23回 DDSカンファランス 2014
- Place of Presentation
  静岡
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] Simultaneous LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 substrate drugs and their metabolites2014
- Author(s)
  Shimako Tanaka, Shinya Uchida, Naoki Inui, Kazuhiko Takeuchi, Hiroshi Watanabe, Noriyuki Namiki
- Organizer
  5th FIP Pharmaceutical Sciences World Congress 2014
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-04-16
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] LC-MS/MSを用いたカクテル試験による薬物相互作用の同時解析2014
- Author(s)
  内田信也、乾直輝、田中紫茉子、小田切圭一、袴田晃央、渡邉裕司、並木徳之
- Organizer
  第35回日本薬理学会学術総会
- Place of Presentation
  松山
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-26460202
[Presentation] 薬物相互作用検出のためのin vivoでのラットおよび健常人対象試験2011
- Author(s)
  内田信也、田中紫茉子、乾直輝、竹内和彦、渡邉裕司、大橋京一、並木徳之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590171
[Presentation] Inhibitory effects of Omega-6 polyunsaturated fatty acids on endothelial function2011
- Author(s)
  Wei J, Takeuchi K, Inui N, Watanabe H
- Organizer
  The 5th China-Japan Joint Meeting of Basic and Clinical Pharmacology
- Place of Presentation
  Urumqi, China
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] ω6-polyunsatulated fatty acids, but not other free fatty acids, evoke endothelial dysfunction by inhibiting store-operated Caentries.2010
- Author(s)
  竹内和彦、Wei Jiazhang、乾直輝、渡邉裕司
- Organizer
  16th World congress on Basic and Clinical Pharmacology
- Place of Presentation
  デンマーク
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] The Influence of CYP2A6 Gene Polymorphism on S-1 Therapy in Non-Small-Cell Lung Cancer Patients.2008
- Author(s)
  Kaida Y, Inui N.
- Organizer
  American Thoracic Society.
- Place of Presentation
  Toronto
- Data Source
  KAKENHI-PROJECT-20590536
[Presentation] 非小細胞肺癌患者におけるCYP2A6遺伝子多型とS-1の薬物動態2008
- Author(s)
  乾直輝
- Organizer
  日本臨床薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590536

1. 須田隆文 (30291397)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. UCHIDA Shinya (80372522)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. TANAKA Shimako (10559925)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. WATANABE Hiroshi (50262803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. IMAI Hiromitsu (30398250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. TAKEUCHI Kazuhiko (00419425)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 小田切圭一 (70529213)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. CHIDA Kingo (40197611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. YAMADA Hiroshi (40265252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KOSUGE Kazuhiro (00283375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 袴田晃央 (60788280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 小幡由佳子 (90432210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 柏倉康治 (70746403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 安井秀樹 (60804937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 岩城孝行 (70509463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 鈴木優子 (20345812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. MIURA Tomoyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. SASANO Tomomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OZAWA Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHINOHARA Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. NOGAMI Yuzuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. FUJISAWA Tomouki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. NAKAMURA Yutaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 穗積宏尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 鈴木勇三

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
26. 森雅紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 河崎秀陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 北川雅敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INUI Naoki 乾 直輝

Inui Naoki 乾 直輝

Research Projects

Research Products

Co-Researchers

Novel therapeutic strategies for COPD targeting the fibrinolysis inhibitor PAI-1

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線維化解除をターゲットとした肺線維化病態の解明と創薬への展開Principal Investigator

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Preparation and clinical evaluation of foam formulations for the treatment of oral mucositis.

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Hypoxia on Pulmonary Endothelial Cells from Bleomycin-Induced Fibrosis MicePrincipal Investigator

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Review Section

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Changes in pulmonary endothelial cell and fibroblast properties during bleomycin-induced pulmonary fibrosisPrincipal Investigator

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Development and validation of the cocktail study for the method in detection of drug-drug interactions

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Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological tool

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Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers

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The usefulness of chemotherapy with S-1 for Japanese patients with non-small-cell lung cancer based on CYP2A6*4 gene polymorphismPrincipal Investigator

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[Journal Article] Prevalence and clinical features of progressive pulmonary fibrosis in patients with unclassifiable idiopathic interstitial pneumonia: A post hoc analysis of prospective multicenter registry2025

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[Journal Article] Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts2025

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[Journal Article] Need for reassessment of the diagnosis of interstitial lung disease using a multidisciplinary discussion approach2025

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[Journal Article] The role of arterial stiffness as assessed by the cardio-ankle vascular index in patients with chronic obstructive pulmonary disease2025

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[Journal Article] Antifibrotics and mortality in idiopathic pulmonary fibrosis: external validity and avoidance of immortal time bias2024

INUI Naoki 乾直輝

Inui Naoki 乾直輝