WATANABE Hiroshi 渡邉裕司

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… Alternative Names

渡邉裕司ワタナベヒロシ

渡邊裕司ワタナベヒロシ

WATANABE Hirosi 渡邉裕司

渡邉浩司ワタナベヒロシ

渡辺裕司ワタナベヒロシ

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Researcher Number	50262803
External Links
Affiliation (Current)	2025: 浜松医科大学, 医学部, 理事
Affiliation (based on the past Project Information) *help	2019 – 2020: 浜松医科大学, 医学部, 理事 2018: 浜松医科大学, 医学部, 理事・副学長 2006 – 2018: 浜松医科大学, 医学部, 教授 2008: 浜松医科大学, 医学部・臨床薬理学, 教授 2007: 浜松医科大学, 教授 … More 2004: Hamamatsu University School of Medicine, Clinical Pharmacology and Ther apeutics, Professor, 医学部, 教授 2004: 浜松医科大学, 医学部, 教授 2002 – 2003: 浜松医科大学, 医学部, 助教授 1998 – 2000: 浜松医科大学, 医学部, 助教授 1997: 浜松医科大学, 医学部・附属病院, 文部教官助手 1997: Hamamatsu University School of Medicine, Internal Medicine III,Research Associate, 医学部附属病院, 助手 1995 – 1996: 浜松医科大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Applied pharmacology / General pharmacology Except Principal Investigator Applied pharmacology / Gastroenterology / Circulatory organs internal medicine / Applied health science / General internal medicine(including psychosomatic medicine) / Laboratory medicine / Rehabilitation science/Welfare engineering / General pharmacology
Keywords	Principal Investigator カルシウム / 血管内皮細胞 / ミオシン軽鎖キナーゼ / Calcium / カルシウムイオン / 遺伝子多型 / パラオキソナーゼ(PON)3 / 肥満 / 動脈硬化 / 民族差 … More / パロキソナーゼ3 / 遺伝的多型 / 抗動脈硬化作用 / 薬物動態 / シンバスタチン / パラオキソナーゼ / 臨床薬理学 / caspase / ER stress / calcium / endothelial cell / apoptosis / PI3キナーゼ / Akt / カスパーゼ / 小胞体ストレス / アポトーシス / Endothelium-derived hyperpolarizing factor / Nitric Oxide / Endothelial cell / Myosin light chain kinase / 内皮依存性血管拡張因子 / 内皮依存性過分極反応 / 一酸化窒素 / 内皮依存性過分極因子 / 一酸化窒素(NO) / Myosin Light-Chain / Fluid flow / Thapsigargin / Bradykinin / Myosin Light-Chain Kinase / Endothelial Cells / 蛍光色素法 / 細胞内pH / 細胞内カルシウムイオン / 細胞骨格 / シェアストレス / ミオシン軽鎖 / 流れ負荷 / サプシガ-ゲン / ブラジキニン / 血管内皮細い胞 / 創薬 / ゲノム / 循環 / マクロファージ … More Except Principal Investigator 血管内皮細胞 / 高齢者 / CYP2C9 / NSAID / 薬物代謝酵素 / 線溶活性 / 健康長寿 / 閉経後高齢女性 / ADL / 東アジア / 高齢者総合機能評価 / ホルモン補充療法 / 閉経後女性 / 後期高齢女性 / 動脈硬化性疾患 / 生活習慣病 / 薬剤反応性 / 老年内科学 / 性差医療 / ２型糖尿病 / 高血糖 / 脂質異常症 / 糖尿病 / 内皮細胞老化 / 老化物質 / 糖尿病血管合併症 / 血管老化 / 老年医学 / 動脈硬化症 / 一酸化窒素 / 細胞老化 / 薬理学 / 液体クロマトグラフィー質量分析法 / 薬物相互作用 / 治療薬物モニタリング / 薬物濃度 / 肺高血圧症 / HPLC / 液体クロマトグラフィー質量分析法 / Prostaglandin / 13CO2 / Naproxen / NSAIDS / 呼気テスト / 13C / ナプロキセン / 呼気試験 / オミックス / グライコブロッティング法 / 極低出生体重児 / 予防医学 / エピゲノミクス / 予知医学 / N-グリカン / 不当軽量児 / 低出生体重児 / 胎児プログラミング / グリコブロッティング / グライコミクス / 薬物動態 / 血漿中薬物濃度 / 緑茶カテキン / 体内動態 / 血漿中濃度 / 日本人 / スタチン剤 / シトクロームP-450 / 相互作用 / シンバスタチン / カテキン類 / 緑茶 / 近赤外線 / 脳梗塞 / 近赤外時間分解分光法 / 脳血流 / 内皮バリア機能 / プラスミノゲンアクチベータインヒビター１ / 組織型プラスミノゲンアクチベータ / 組織プラスミノゲンアクチベータ / 可視化解析 / 近赤外線時間分解分光法 / 反応性充血 / 血管内皮機能 / H2S / 個別化療法 / 遺伝子多型 / 胃粘膜傷害 / 抗癌剤S1 / CYP2A6 / 肺癌 / 抗癌剤S-1 / 個別化治療 / 薬物治療学 / 血管トーヌス / プラスミノーゲンアクチベーターインヒビター1 / 反射蛍光顕微鏡 / 組織プラスミノーゲンアクチベーター / プラスミノゲンアクチベーターインヒビター1 / 全反射蛍光顕微鏡 / 開口放出 / 組織型プラスミノゲンアクチベーター / 遊離脂肪酸 / カルシウム / プロスタグランジンI2 / NO / 内皮依存性血管拡張因子 / 血管内皮 / 虚血性脳卒中 / 循環 Less

Development of the blood concentration measurement system and implementation of therapeutic drug monitoring (TDM) of a novel drug for treatment of pulmonary hypertension.
- Principal Investigator
  
  Odagiri Keiichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Clinical pharmacology study on drug-degrading esterase PON3, gene polymorphism and pharmacokinetic influencePrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
The Finding of Biomarker through the Study of Vascular Senescence and Diabetic Angiopathy
- Principal Investigator
  
  Hayashi Toshio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Nagoya University
The Study of Gender Based Medicine to Maintain the Healthy Life of Elderly
- Principal Investigator
  
  林登志雄
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Nagoya University
[13C]-naproxen breath test can predict the gastric mucosal injury induced by naproxen
- Principal Investigator
  
  FURUTA TAKAHISA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hamamatsu University School of Medicine
Exploratory Research for Fetal Programming Effects by Using Omics Analysis including Epigenomics
- Principal Investigator
  
  MAEKAWA Masato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hamamatsu University School of Medicine
Postural-related Cerebral Hemodynamic Responses Assessed by Near Infrared Spectroscopy in Patients with Chronic Cerebral Infarction
- Principal Investigator
  
  IRISAWA Hiroshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Hamamatsu University School of Medicine
Translational research of phama and food by greentea
- Principal Investigator
  
  YAMADA Shizuo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Shizuoka
Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological tool
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Imaging analysis of the role of newly proposed cell surface-associated fibrinolysis mechanism in the regulation of endothelial barrier function.
- Principal Investigator
  
  SUZUKI Yuko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hamamatsu University School of Medicine
The usefulness of chemotherapy with S-1 for Japanese patients with non-small-cell lung cancer based on CYP2A6*4 gene polymorphism
- Principal Investigator
  
  INUI Naoki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Development of genomics-based prophylaxis strategy for NSIAD ulcer
- Principal Investigator
  
  FURUTA Takahisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hamamatsu University School of Medicine
Involvement of free fatty acids and 20-hydroxyeicosatetraenoic acid(20-HETE)in ischemic stroke
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Unique secretory dynamics of tissue plasminogen activator and vascular function
- Principal Investigator
  
  SUZUKI Yuko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hamamatsu University School of Medicine
Calcium entry channel related gene expression profiles of endothelial cells by micro-bead array analysis and target gene identification for drug discoveryPrincipal Investigator
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Endothelial cell ER stress and Ca^<2+> signaling pathwayPrincipal Investigator
- Principal Investigator
  
  WATANABE Hirosi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hamamatsu University School of Medicine
ミオシン軽鎖キナーゼにより調節される細胞内Ca^<2+>流入機構の分子生物学的検討Principal Investigator
- Principal Investigator
  
  渡邊裕司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hamamatsu University School of Medicine
Role of Myosin Light-Chain Kinase in the Regulation of Endothelial Functions and Calcium SignalingPrincipal Investigator
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hamamatsu University School of Medicine
Intracellular Signal Transduction and Cytoskeleton in Endothelial CellsPrincipal Investigator
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hamamatsu University School of Medicine

[Book] 今日の治療指針20202020
- Author(s)
  越前宏俊、渡邉裕司
- Total Pages
  2192
- Publisher
  医学書院
- ISBN
  9784260039390
- Data Source
  KAKENHI-PROJECT-17K08949
[Book] 治療薬のデータブック2019
- Author(s)
  渡邉裕司
- Total Pages
  68
- Publisher
  日本医事新報
- Data Source
  KAKENHI-PROJECT-17K08949
[Book] 今日の治療指針20192019
- Author(s)
  越前宏俊、渡邉裕司
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17K08949
[Book] 今日の治療指針20182018
- Author(s)
  越前宏俊，渡邉裕司
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17K08949
[Book] 今日の治療指針　2年版［ポケット判］2017
- Author(s)
  越前宏俊,渡邉裕司
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17K08949
[Book] 内科学　第11版2017
- Author(s)
  渡邉裕司
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-17K08949
[Book] パーフェクトガイド検査値事典第2版2014
- Author(s)
  高木　康、〆谷直人、野村文夫、澤部祐司、吉田俊彦、清宮正徳、梅村啓史、戸塚　実、日野田裕治、杉浦哲郎、高橋延行、橋本直明、光井　洋、池田　均、中川勇人、高橋伯夫、渡辺　毅、浅井　淳、飯野和美、前川真人
- Total Pages
  707
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-24390144
[Book] AHA Highlights 2007, Cardiovascular Pharmacogenomics : Advances and Challenges in Personalized Medicine2007
- Author(s)
  渡邉裕司
- Publisher
  協和企画
- Data Source
  KAKENHI-PROJECT-18390074
[Book] The Vascular Endothelium I Calcium Signalling in the Endothelium2006
- Author(s)
  Tran QK, Watanabe H
- Publisher
  Springer,Handbook of Experimental Pharmacology
- Data Source
  KAKENHI-PROJECT-18390074
[Journal Article] 臨床研究法の現状における課題と運用改善に向けた提言：GCP・医学系指針及び海外制度との比較から－第1報　医薬品等の品質・安全性の確保－2019
- Author(s)
  栗原千絵子，鈴木千恵子，小池竜司，佐藤弥生，渡邉裕司
- Journal Title
  
  臨床評価
  
  Volume: 47(1) Pages: 127-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08949
[Journal Article] Transient Laterality of Cerebral Oxygenation Changes in Response to Head-of-Bed Manipulation in Acute Ischemic Stroke2019
- Author(s)
  Katayama、Odagiri、Hakamata、Inui、Yamauchi、Watanabe
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 8 Issue: 10 Pages: 1739-1739
- DOI
  10.3390/jcm8101739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08949
[Journal Article] Effect of rifampicin and clarithromycin on the CYP3A activity in patients with Mycobacterium avium complex,2019
- Author(s)
  Akiyama N, Inui N, Mori K, Nakamura Y, Hayakawa H, Tanaka S, Uchida S, Namiki N, Watanabe H, Suda T,
- Journal Title
  
  J Thorac Dis
  
  Volume: 11(9) Pages: 3814-3821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08949
[Journal Article] Clinical Outcomes and Treatment Options in Patients With Pulmonary Hypertension Who Received Pulmonary Hypertension-Specific Drugs－Single-Center Case Series－2019
- Author(s)
  Kamiya C, Odagiri K , Hakamata A, Inui N, Watanabe H
- Journal Title
  
  Circulation Reports
  
  Volume: 1 Pages: 389-395
- NAID
  130007705469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08949
[Journal Article] Napping Improves HRV in Older Patients wiith Cardiovascular Risk Factors.2019
- Author(s)
  Nakayama N, Hayashi T, Miyachi M, Negi K, Watanabe K, Hirai M.
- Journal Title
  
  Western Journal of Nursing Research
  
  Volume: - Issue: 9 Pages: 1241-1253
- DOI
  10.1177/0193945918824603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09297, KAKENHI-PROJECT-16K12081, KAKENHI-PROJECT-17H04500
[Journal Article] Recommended use of Cut-off Folate Concentration in Serum and Erythrocyte(Red Blood Cell) as Expressed by Folic Acid Equivalent for the Diagnosis of Deficiency in Deliberating the Creation on Dietary Reference Intakes.2015
- Author(s)
  Ihara H, Hirota K, Watanabe T, Totani M, Hashizume N, Aoki Y, Nagashima Y, Kamioka K, Onda K, Sunahara S, Suzuki T, Itabashi M, Ishibashi M, Ito S, Ohashi K, Ohta Y, Nobori T, Fujishiro K, Maekawa M, Miura M, Miyano H, Ando T, Nishimura K
- Journal Title
  
  Austin J Nutri Food Sci
  
  Volume: 3(1) Pages: 1055-1056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390144
[Journal Article] Eradication of H. pylori infection in patients allergic to penicillin by the triple therapy with a PPI, metronidazole and sitafloxacin2014
- Author(s)
  Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
- Journal Title
  
  Intern Med
  
  Volume: 53 Pages: 571-575
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460935
[Journal Article] Final height and cardiometabolic outcomes in young adults with very low birth weight (< 1500 g).2014
- Author(s)
  Sato R, Maekawa M, Genma R, Shirai K, Ohki S, Morita H, Suda T, Watanabe H
- Journal Title
  
  PLOS ONE
  
  Volume: 9 (11) Issue: 11 Pages: 1-9
- DOI
  10.1371/journal.pone.0112286
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390144, KAKENHI-PROJECT-26670275
[Journal Article] Cell line differences in replication timing of human glutamate receptor genes and other large genes associated with neuraldisease.2014
- Author(s)
  Watanabe Y, Shibata K, Maekawa M
- Journal Title
  
  Epigenetics.
  
  Volume: 9 (10) Pages: 1350-1359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390144
[Journal Article] Dosing Schemes of Amoxicillin on Eradication Rates of Helicobacter pylori With Amoxicillin-Based Triple Therapy2014
- Author(s)
  Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 54 Issue: 3 Pages: 258-266
- DOI
  10.1002/jcph.195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590913, KAKENHI-PROJECT-26460935
[Journal Article] Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan2014
- Author(s)
  Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani TSahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 29 Issue: 3 Pages: 487-493
- DOI
  10.1111/jgh.12442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590913, KAKENHI-PROJECT-25460948, KAKENHI-PROJECT-26460935
[Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes2013
- Author(s)
  Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Jose Pablo Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
- Journal Title
  
  Drug Metab. Pharmacokinet
  
  Volume: 28 Pages: 244-9
- NAID
  210000170598
- Data Source
  KAKENHI-PROJECT-23659287
[Journal Article] Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS2013
- Author(s)
  Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Sekihiro Tamaki, Jose P. Werba, Monica Giroli, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
- Journal Title
  
  Biomed.Chromatogr
  
  Volume: 27 Pages: 1-6
- Data Source
  KAKENHI-PROJECT-23659287
[Journal Article] Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6, and 3A activities in human liver and intestinal microsomes.2013
- Author(s)
  Shingen Misaka,Keisuke Kawabe,Satomi Onoue,Jose Pablo Werba,Monica Giroli,Sekimoto Tamaki,Toshiyuki Kan,Junko Kimura, Hiroshi Watanabe,Shizuo Yamada
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: in press
- NAID
  210000170598
- Data Source
  KAKENHI-PROJECT-23659287
[Journal Article] R/G-band boundaries: Genomic instability and human disease2013
- Author(s)
  Watanabe Y, Maekawa M
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 419 Pages: 108-112
- DOI
  10.1016/j.cca.2013.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659295, KAKENHI-PROJECT-24390144, KAKENHI-PROJECT-25430168
[Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes2013
- Author(s)
  22. Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José Pablo Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 28 Pages: 244-249
- NAID
  210000170598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659287
[Journal Article] Methods and Strategies to Determine Epigenetic Variati on in Human Disease2012
- Author(s)
  Watanabe Y, Maekawa M
- Journal Title
  
  Epigenetics in Human Disease
  
  Volume: 2 Pages: 2-27
- DOI
  10.1016/b978-0-12-388415-2.00002-0
- ISBN
  9780123884152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659295, KAKENHI-PROJECT-24390144
[Journal Article] Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS2012
- Author(s)
  Shingen Misaka,Keisuke Kawabe,Satomi Onoue,Jose Pablo Werba,Monica Giroli,Junko Kimura,Hiroshi Watanabe, Shizuo yamada
- Journal Title
  
  Biomed.Chromatogr
  
  Volume: 27 Pages: 1-6
- Data Source
  KAKENHI-PROJECT-23659287
[Journal Article] Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS2012
- Author(s)
  Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Jose Pablo Werba, Monica Giroli, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
- Journal Title
  
  Biomed. Chromatogr
  
  Volume: 27 Pages: 1-6
- Data Source
  KAKENHI-PROJECT-23659287
[Journal Article] Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [^<13>C]-aminopyrine breath test.2011
- Author(s)
  Kodaira C, Shinya Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T.
- Journal Title
  
  J Clin Pharmacol [Epub ahead of print].
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [^<13>C]-aminopyrine breath test2011
- Author(s)
  Kodaira C, Shinya Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T*
- Journal Title
  
  J Clin Pharmacol
  
  Volume: Mar 17(Epub ahead of prin)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole2009
- Author(s)
  Furuta T, Sugimoto M, Kodaira C, Nishino M, Ymade M, Ikutna M, Shirai N, Watanabe H, limemura K, Kimura M, Hishida A
- Journal Title
  
  Eur J Clin Pharmacol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole.2009
- Author(s)
  Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Ikuma M, Shirai N, Watanabe H, Umemura K, Kimura M, Hishida A.
- Journal Title
  
  Eur J Clin Pharmacol 65
  
  Pages: 693-698
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] [^<13>C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole.2009
- Author(s)
  Furuta T, Kodaira C, Nishino M, Yamade M, Sugiraoto M^<2)>, Ikuma M, Hishida A, Watanabe H, Umeniura K.
- Journal Title
  
  Aliment Pharmacol Ther (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] Effect of MDRI C3435T polymorphism on lansoprazole in healthy Japanese subjects.2009
- Author(s)
  Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T
- Journal Title
  
  Eur J Clin Pharmacol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] Effects of statins on the pharmacokinetics of midazolam in healthy volunteers.2009
- Author(s)
  Kokudai M, Inui N, Takeuchi K, Sakaeda T, Kagawa Y, Watanabe H.
- Journal Title
  
  J Clin Pharmacol. 49
  
  Pages: 568-573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] [^<13>C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole2009
- Author(s)
  Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M2), Ikuma M, Hishida A, Watanabe H, Umemura K.
- Journal Title
  
  Aliment Pharmacol Ther 30
  
  Pages: 294-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] [13C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole.2009
- Author(s)
  Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M2), Ikuma M, Hishida A, Watanabe H, Umemura K.
- Journal Title
  
  Aliment Pharmacol Ther 30
  
  Pages: 294-300
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects.2009
- Author(s)
  Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T.
- Journal Title
  
  Eur J Clin Pharmacol 65
  
  Pages: 593-600
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole2009
- Author(s)
  Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Ikuma M, Shirai N, Watanabe H, Umemura K, Kimura M, Hishida A
- Journal Title
  
  Eur J Clin Pharmacol 65
  
  Pages: 693-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects2009
- Author(s)
  Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T
- Journal Title
  
  Eur J Clin Pharmacol 65
  
  Pages: 593-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590718
[Journal Article] Effect of thyroid hormone on the activity of CYP3A enzyme in humans.2009
- Author(s)
  Takahashi N, Inui N, Morita H, Takeuchi K, Uchida S, Watanabe H, Nakamura H.
- Journal Title
  
  J Clin Pharmacol. 50
  
  Pages: 88-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] 非小細胞肺癌患者における薬物代謝酵素CYP2A6遺伝子多型の存在とS-1の薬物動態に及ぼす影響2008
- Author(s)
  貝田勇介, 乾直輝, 渡邉裕司
- Journal Title
  
  臨床薬理の進歩 29
  
  Pages: 81-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] 血管内皮細胞とERストレス2008
- Author(s)
  渡邉裕司
- Journal Title
  
  血管医学 9(4)
  
  Pages: 51-57
- Data Source
  KAKENHI-PROJECT-18390074
[Journal Article] Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis2008
- Author(s)
  Inui N, Enomoto N, Suda T, Kageyama Y, Watanabe H, Chida K.
- Journal Title
  
  Clin Biochem 41(13)
  
  Pages: 1074-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590858
[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Takeuchi K, Watanabe H
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology 377(4-6)
  
  Pages: 423-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590244
[Journal Article] Cyclooxygenase-dependent vasoconstricting factor(s) in remodeled rat femoral arteries2008
- Author(s)
  Hirao A, Kondo K, Takeuchi K, Inui N, Umemura K, Ohashi K, Watanabe H
- Journal Title
  
  Cardiovasc Res 79
  
  Pages: 161-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390074
[Journal Article] Cyclooxygenese-dependent vasoconstricting factor(s)in remodeled rat femoral arteries2008
- Author(s)
  Hirao A, Kondo K, Takeuchi K, Inui N, Umemura K, Ohashi K, Watanabe H
- Journal Title
  
  Cardiovasc Res 79(1)
  
  Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590858
[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Takeuchi K, Uchida S, Urushida T, Katoh H, Satoh H, Yamada S, Hayashi H, Watanabe H
- Journal Title
  
  Naunyn-Schiniedeberg's Arch Pharmacol 377
  
  Pages: 423-427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390074
[Journal Article] H:Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Takeuchi K, Uchida S, Urushida T, Katoh H, Satoh H, Yamada S, Hayashi H, Watanabe H
- Journal Title
  
  Naunyn-Schmiedeberg's Arch Pharmacol 377
  
  Pages: 423-427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390074
[Journal Article] Misinterpretation of the effect of amylodipine on systolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Watanabe H(他7名)
- Journal Title
  
  Naunun Schmiedebergs Arch Parmacol 377(4-6)
  
  Pages: 423-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590858
[Journal Article] The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer2008
- Author(s)
  Kaida Y, Inui N, Suda T, Nakamura H, Watanabe H, Chida K.
- Journal Title
  
  Clin Pharmacol Ther 83(4)
  
  Pages: 589-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590858
[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H.
- Journal Title
  
  Naunyn-Schmiede berg's Archives of Pharmacology 377(4-6)
  
  Pages: 423-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590244
[Journal Article] The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer2008
- Author(s)
  Kaida Y, Inui N, Suda T, Nakamura H, Watanabe H, Chida K
- Journal Title
  
  Clin Pharmacol Ther 83
  
  Pages: 589-594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] Response to "The Unanswered Question : What Is the Determinant of S-1 Pharmacokinetics?2008
- Author(s)
  Kaida Y, Inui N, Suda T, Watanabe H, Chida K.
- Journal Title
  
  Clin Pharmacol Ther 84
  
  Pages: 204-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590536
[Journal Article] Modification of sarcoplasmic reticulum (SR) Ca^<2+> release by FK506 induces defective excitationcontraction coupling only when SR Ca^<2+> recycling is disturbed2005
- Author(s)
  Yoshihara S, Satoh H, Saotome M, Katoh H, Terada H, Watanabe H, Hayashi H
- Journal Title
  
  Can.J.Physiol.Pharmacol. 83
  
  Pages: 357-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Akt and Ca^<2+> signaling in endothelial cells.2004
- Author(s)
  Ozeki M, Watanabe H, Luo JH, Nakan o T, Takeuchi K, Kureishi Y, Ito M, Na kano T, Ohashi K, Hayashi H.
- Journal Title
  
  MOLECULAR AND CELLULAR BIOCHEMISTRY 259
  
  Pages: 169-176
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Nitric oxide : inhibitory effects on endothelial cell calcium signaling, prostaglandin I_2 production and nitric oxide synthase expression.2004
- Author(s)
  Takeuchi K, Watanabe H, Tran QK, Ozeki M, Sumi D, Hayashi T, Iguchi A, Ignarro LJ, Ohashi K, Hayashi H
- Journal Title
  
  Cardiovascular Research 62
  
  Pages: 194-201
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Akt and Ca^<2+> signaling in endothelial cells.2004
- Author(s)
  Ozeki M, Watanabe H, Luo JH, Nakano T, Takeuchi K, Kureishi Y, Ito M, Nakano T, Ohashi K, Hayashi H.
- Journal Title
  
  Molecular and Cellular Biochemistry 259
  
  Pages: 169-176
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Akt and Ca^<2+> signaling in endothelial cells2004
- Author(s)
  Ozeki M, Watanabe H, Luo JH, Nakano T, Takeuchi K, Kureishi Y, Ito M, Nakano T, Ohashi K, Hayashi H.
- Journal Title
  
  Molecular and Cellular Biochemistry 259
  
  Pages: 169-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Nitric oxide : inhibitory effects on endothelial cell calcium signaling, prostaglandin 12 production and nitric oxide synthase expression.2004
- Author(s)
  Takeuchi K, Watanabe H, Tran QK, Ozeki M, Sumi D, Hayashi T, Iguchi A, Ignarro LJ, Ohashi K, Hayashi H
- Journal Title
  
  CARDIOVASCULAR RESEARCH 62
  
  Pages: 194-201
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Nitric oxide : inhibitory effects on endothelial cell calcium signaling, prostaglandin I_2 production and nitric oxide synthase expression2004
- Author(s)
  Takeuchi K, Watanabe H, Tran QK, Ozeki M, Sumi D, Hayashi T, Iguchi A, Ignarro LJ, Ohashi K, Hayashi H
- Journal Title
  
  Cardiovascular Research 62
  
  Pages: 194-201
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Effects of cytochrome P450 inhibitors on agonistinduced Ca^<2+> responses and production of NO and PGI_2 in vascular endothelial cells2003
- Author(s)
  Takeuchi K, Watanabe H, Tran QK, Ozeki M, Uehara A, Katoh H, Satoh H, Terada H, Ohashi K, Hayashi H
- Journal Title
  
  Molecular and Cellular Biochemistry 248
  
  Pages: 129-134
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570652
[Journal Article] Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca^<2+> entry via non-selective cation channels
- Author(s)
  Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H
- Journal Title
  
  Cardiovasc Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390074
[Journal Article] Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca^<2+> entry via nonselective cation channels
- Author(s)
  Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H.
- Journal Title
  
  Cardiovascular Research (in press)
- Data Source
  KAKENHI-PROJECT-19590244
[Journal Article] Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca^<2+> entry via non-selective cation channels Corresponding Author
- Author(s)
  Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H
- Journal Title
  
  Cardiovasc Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] 健常者におけるSelexipag とClopidogrel併用時の薬物動態について2019
- Author(s)
  神谷千明,袴田晃央,片山直紀,乾直輝, 小田切圭一,田中紫茉子,内田信也,並木徳之,渡邉裕司
- Organizer
  第4回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 成人肺高血圧患者における肺高血圧治療薬の母集団薬物動態解析2019
- Author(s)
  田中紫茉子、内田信也、中川篤毅、袴田晃央、神谷千明、小田切圭一、乾　直輝、渡邉裕司、並木徳之
- Organizer
  第4回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] ベラプロストをセレキシパグに変更したPAH患者での薬物濃度2019
- Author(s)
  小田切圭一,神谷千明,袴田晃央,乾直輝,田中紫茉子,内田信也,渡邉裕司
- Organizer
  第4回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 健常者におけるSelexipagとClopidogrel併用時の薬物動態について2019
- Author(s)
  神谷千明、袴田晃央、片山直紀、乾直輝、小田切圭一、田中紫茉子、内田信也、渡邉裕司
- Organizer
  第4回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] Role of NO-ｓGC-ｃGMP axis in Pulmonary Arterial Hypertension2019
- Author(s)
  Watanabe H
- Organizer
  2019 TPHA-Autumn conference -PCPHS-TPHA Joint PH Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 日本人肺高血圧患者における肺高血圧症治療薬の血中濃度に及ぼす影響因子の検討2019
- Author(s)
  田中紫茉子、内田信也、中川篤毅、袴田晃央、神谷千明、小田切圭一、乾直樹、中嶌八隅、森善樹、渡邉裕司、並木徳之
- Organizer
  日本臨床薬理学会東海・北陸地方会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] 健常成人におけるシトクロムP450 2C8阻害薬クロピドグレル併用時のセレキシパグの薬物動態について2019
- Author(s)
  片山直紀、小田切圭一、神谷千明、袴田晃央、乾直輝、田中紫茉子、内田信也、渡邉裕司
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] Impairment of cerebral blood flow autoregulation in patients with acute cerebral infarction recovered within 7-10 days after onset2019
- Author(s)
  Katayama N,Odagiri K, Hakamata A,Inui N, Yamauchi K,Watanabe H
- Organizer
  International Stroke Conference (AHA）2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 健常成人におけるシトクロムP4502C8阻害薬クロビドグレル併用時のセレキシパグの薬物動態について2019
- Author(s)
  片山直紀,小田切圭一,神谷千明,袴田晃央,乾直輝,田中紫茉子,内田信也,渡邉裕司
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 成人肺高血圧患者における肺高血圧症治療薬の母集団薬物動態解析2019
- Author(s)
  田中紫茉子,内田信也,中川篤毅,袴田晃央,神谷千明,小田切圭一,乾直輝,渡邉裕司,並木徳之
- Organizer
  第4回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] ベラプロストをセレキシパグに変更したPAH患者での薬物濃度2019
- Author(s)
  小田切圭一、神谷千明、袴田晃央、乾直輝、田中紫茉子、内田信也、渡邉裕司
- Organizer
  第4回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] 肺高血圧症患者におけるホスホジエステラーゼ5阻害薬およびエンドセリン受容体拮抗薬の血漿中濃度2019
- Author(s)
  中川篤毅、田中紫茉子、内田信也、佐藤実季、袴田晃央、神谷千明、石川貴充、小田切圭一、乾　直輝、渡邉裕司、並木徳之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] 肺高血圧症治療薬の日本人患者における血漿中濃度2018
- Author(s)
  佐藤実季、田中紫茉子、袴田晃央、野神優月、神谷千明、石川貴充、内田信也、小田切圭一、乾　直輝、並木徳之、渡邉裕司
- Organizer
  第3回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] TDMでの応用を目的とした経口肺高血圧症治療薬の6種同時定量法の検討2018
- Author(s)
  佐藤実季、田中紫茉子、野神優月、神谷千明、袴田晃央、小田切圭一、乾直輝、内田信也、渡邉裕司、並木徳之
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] The Analysis of Plasma Concentration of Sildenafil, Tadalafil and Ambrisentan in Japanese Childrenwith Pulmonary Arterial Hypertension2018
- Author(s)
  Akio Hakamata, Shimako Tanaka, Tomotaka Murakami, Nao Inoue, Sachie Kaneko, Yasumi Nakashima, Yoshiki Mori, Chiaki Kamiya, Shinya Uchida, Keiichi Odagiri, Naoki Inui and Hiroshi Watanabe
- Organizer
  American Heart Association Scientific session 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] TDMでの応用を目的とした経口肺高血圧症治療薬の6種同時定量法の検討2018
- Author(s)
  佐藤実季、田中紫茉子、野神優月、神谷千明、袴田晃央、小田切圭一、乾直輝、内田信也、渡邉裕司、並木徳之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] Genotype-specific effects of cytochrome P450 inducers and inhibitors on CYP2C19 enzyme activity.2018
- Author(s)
  Kamiya C,Watanabe H
- Organizer
  第39回日本臨床薬理学会学術総会・WCP2018(ポスター）
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 治療的薬物濃度モニタリング(TDM）を用いて薬剤調整を行った肝・腎機能障害合併肺高血圧症の1例2017
- Author(s)
  袴田晃央,石川貴充,田中紫茉子,神谷千明,小田切圭一,内田信也,乾直輝,渡邉裕司
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 新規肺高血圧症治療薬selexipag及び活性代謝物の血漿中薬物濃度測定法の確立2017
- Author(s)
  野神優月、田中紫茉子、渡邊龍矢、佐藤実季、小田切圭一、袴田晃央、内田信也、渡邉裕司、並木徳之
- Organizer
  第34回日本TDM学会・学術大会（京都）
- Data Source
  KAKENHI-PROJECT-17K08948
[Presentation] 肺高血圧症治療薬における薬物治療モニタリング(TDM）の検討2017
- Author(s)
  内田信也,袴田晃央,田中紫茉子,神谷千明,石川貴充,小田切圭一,乾直輝,森善樹,並木徳之,渡邉裕司
- Organizer
  第2回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] cytochrome P450における遺伝子多型と酵素誘導／阻害の関連2017
- Author(s)
  神谷千明,小田切圭一,宮川幸子,袴田晃央,乾直輝,田中紫茉子,内田信也,並木徳之,渡邉裕司
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] 薬物増量にTDMを用いた肝・腎機能障害合併肺高血圧症の例2017
- Author(s)
  袴田晃央，石川貴充,田中紫茉子,神谷千明,小田切圭一,内田信也,乾直輝，渡邉裕司
- Organizer
  第2回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08949
[Presentation] Dual therapy with vonoprazan and amoxicillin is as effective as those with standard PPI-based triple therapy with amoxicillin and clarithromycin or metronidazole in Japan2016
- Author(s)
  Furuta T, Sahara S, Ichikawa H, Kagami T, Nagata E, Odagiri K, Umemura K, Watanabe H
- Organizer
  ASCPT 2016 annual meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460935
[Presentation] Effect of comsumption of catechin-rich green tea on pharmacokinetics of simvastatin in helthy volunteers2013
- Author(s)
  S.Yamada, S.Misaka, K.Tanabe, A.osano, K.takeuchi, J.P.Werba, H.watanabe
- Organizer
  Pharma-nutrition 2013
- Place of Presentation
  シンガポール
- Data Source
  KAKENHI-PROJECT-23659287
[Presentation] 極低出生体重児(Very low birth weight infants ; VLBW<1500g)の若年成人期における耐糖能2012
- Author(s)
  佐藤亮介, 渡邉裕司, 白井憲司, 大木茂, 源馬理恵子, 森田浩, 井上永介, 竹内正弘, 前川真人, 中村浩淑
- Organizer
  日本糖尿病学会
- Place of Presentation
  横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-24390144
[Presentation] Biomarkers for Endothelial Function.2012
- Author(s)
  Takeuchi K, Watanabe H
- Organizer
  第33回日本臨床薬理学会学術総会 BPS/JSCPT Joint Symposium
- Place of Presentation
  那覇
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] 血管皮細胞機能に対する遊離脂肪酸の影響2011
- Author(s)
  竹内和彦, Wei Jiazhang, 渡邉裕司
- Organizer
  第4回静岡県血栓と血管フォーラム
- Place of Presentation
  静岡
- Year and Date
  2011-01-02
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] 健常人における臨床薬の体内動態に及ぼすカテキン類高含有緑茶の影響2011
- Author(s)
  川邉圭佑、三坂眞元、竹内和彦、田邉健樹、小佐野郁香、乾直輝、尾上誠良、Jose P. Werba、木村純子、渡邉裕司、山田静雄
- Organizer
  第32回日本臨床薬理学会 (講演要旨集 p.S271)
- Place of Presentation
  浜松
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23659287
[Presentation] Omega-6 PUFA- induced endothelial dysfunction2011
- Author(s)
  Wei J, Takeuchi K Watanabe H
- Organizer
  第75 日本循環器学会学術年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-20
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] 健常人における臨床薬の体内動態に及ぼすカテキン類高含有緑茶の影響2011
- Author(s)
  川邉圭佑、三坂眞元、竹内和彦、田邉健樹、小佐野郁香、乾直輝、尾上誠良、Jose P. Werba、木村純子、渡邉裕司、山田静雄
- Organizer
  第32回日本臨床薬理学会、講演要旨集　p.S271、
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23659287
[Presentation] Inhibitory effects of Omega-6 polyunsaturated fatty acids on endothelial function2011
- Author(s)
  Wei J, Takeuchi K, Inui N, Watanabe H
- Organizer
  The 5th China-Japan Joint Meeting of Basic and Clinical Pharmacology
- Place of Presentation
  Urumqi, China
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] ω6-polyunsatulated fatty acids, but not other free fatty acids, evoke endothelial dysfunction by inhibiting store-operated Caentries.2010
- Author(s)
  竹内和彦、Wei Jiazhang、乾直輝、渡邉裕司
- Organizer
  16th World congress on Basic and Clinical Pharmacology
- Place of Presentation
  デンマーク
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] The functional changes in regenerated endothelial cells.2010
- Author(s)
  竹内和彦、渡邉裕司
- Organizer
  XXth World Congress of the ISHR
- Place of Presentation
  京都
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] Omega-6 Ployunsaturated Fatty Acids, Arachidonic and Linoleic Acids, but not Other Free Fatty Acids, Suppress Endothelial Calcium Signaling and Functions2009
- Author(s)
  Takeuchi K, Watanabe H
- Organizer
  The73st Annual Scientific Meeting the Japanese Circulation Society/ P
- Place of Presentation
  大阪
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] 酸性環境下における血管内皮機能2009
- Author(s)
  竹内和彦、浅井正嘉、渡邉裕司
- Organizer
  第9回日本NO学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Omega-6 polyunsaturated fatty acids, arachidonic and linoleic acids, but not other free fatty acids, suppress endothelial Ca^<2+> signaling and functions2009
- Author(s)
  Takeuchi K, Watanabe H.
- Organizer
  第73回日本循環器学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Omega-6 Polyunsaturated Fatty Acids, Arachidonic and Linoleic acids, but not other Free Fatty Acids, Suppress Endothelial Ca2+ Signaling and Functions2009
- Author(s)
  Takeuchi K, Asai M, Watanabe H
- Organizer
  第73回日本循環器学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] [13C]-PANTOPRAZOLE BREATH TEST TO PREDICT EFFICACY OF PROTON PUMP INHIBITOR2009
- Author(s)
  Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M, Ikuma M, Hishida A, Watanabe H, Umemura K.
- Organizer
  UEGW 2009
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-20590718
[Presentation] Free Fatty Acids (FFAs), Arachidonic and Linoleic Acids but not other FFAs, Suppress Endothelial Function by lnhibiting Endothelial Ca2+ Responses2008
- Author(s)
  Takeuchi K , Iida K, Watanabe H
- Organizer
  The72st Annual Scientific Meeting the Japanese Circulation Society/P
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Extracellular but not Intracellular Acidosis Suppresses Endothelial Function by nhibiting Intracellular Calcium Responses2008
- Author(s)
  Asai M, Takeuchi K, Urushida T, Katou H, Satoh H, Hayashi H, Watanabe H
- Organizer
  The72st Annual Scientific Meeting the Japanese Circulation Society/P
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Free Fatty Acids (FFAs), Arachidonic and Linoleic Acids but not other FFAs,Suppress Endothelial Function by Inhibiting Endothelial Ca2+ Responses2008
- Author(s)
  Takeuchi K, Iida K, Watanabe H
- Organizer
  第72回日本循環器学会学術総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Endothelial Ca^<2+>-Control in health and disease2008
- Author(s)
  Watanabe H
- Organizer
  74th Anllual Meeting of the German Cardiac Society
- Place of Presentation
  Mannheim
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] H:Regenerated Endothelium Produces not Vasodilative but Vasoconstrictive Prostanoid(s) via Cyclooxygenase - dependent Pathway2008
- Author(s)
  Takeuchi K , Hirao A, Iida K, Ohashi K, Watanabe H
- Organizer
  The72st Annual Scientific Meeting the Japanese Circulation Society
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Extracellular but not Intracellular Acidosis Suppresses Endothelial Function by Inkibiting Intracellular Calcium Responses2008
- Author(s)
  Alai M, Takeuchi K, Urushida T, Katou H, Satoh H, Hayashi H, Watanabe H
- Organizer
  The 72st Annual Scientific Meeting the Japanese Circulation Society/P
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Free fatty acids(FFAs), arachidonic and linoleic acids but not other FFAs, suppress endothelial function by inhibiting endothelial Ca^<2+> responses2008
- Author(s)
  Takeuchi K, Watanabe H.
- Organizer
  第73回日本循環器学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Antiproliferative Effect of Cyclic AMP on Human Umbilical Vein Endothelial Cells through TGF-beta Inducing p21 (Cip1/Waf1) Expression2007
- Author(s)
  Takeuchi K, Yang Yingbao,Watanabe H
- Organizer
  The71st Annual Scientific Meeting the Japanese Circulation Society/P
- Place of Presentation
  神戸
- Year and Date
  2007-03-17
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] H : Biomarkers in cardiovascular diseases : A new tool to evaluate endothelial function2007
- Author(s)
  Takeuchi K, Utsumi A, Inui N, Watanabe H
- Organizer
  The 3rd China-Japan Joint Meeting of Basic and Clinical Pharmacology/P
- Place of Presentation
  Dalian(China)
- Year and Date
  2007-08-23
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Protease-activated receptor(PAR)を介する血管内皮細胞内カルシウム応答に対するブラジキニン(BK)およびBK受容体拮抗薬の作用2007
- Author(s)
  竹内和彦,内海明子,乾直輝,渡邉裕司
- Organizer
  第28回日本臨床薬理学会年会/P
- Place of Presentation
  栃木
- Year and Date
  2007-11-29
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Direct Effect of ACE Inhibitors on Endothelium : ACE Inhibitors Enhance Kallikrein-induced Ca2+ Responses via Endogenous Bradykinin Endothelial Cells2007
- Author(s)
  Takeuchi K, Watanabe H
- Organizer
  The71st Annual Scientific Meeting the Japanese Circulation Society/P
- Place of Presentation
  神戸
- Year and Date
  2007-03-17
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Regenerated endothelial cells produce vasoconstrictive prostanoid(s) rather than vasodilative prostanoid(s) through COX-1 and COX-2 dependent pathways2006
- Author(s)
  Hirao A, Kondo K, Takeuchi K, Umemura K, Watanabe H
- Organizer
  The 79th Scientific Sessions of American Heart Association
- Place of Presentation
  Chicago(USA)
- Year and Date
  2006-11-14
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] カリクレインによる血管内皮細胞内カルシウム応答の変化の検討2006
- Author(s)
  竹内和彦, 中村玲子, 影山美智代, 平尾晃子, 渡邉裕司
- Organizer
  日本循環器学会第128回東海・第113回北陸合同地方会
- Place of Presentation
  名古屋
- Year and Date
  2006-11-05
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] カリクレイン誘導性血管内皮細胞内カルシウム応答に対するACE阻害薬の作用2006
- Author(s)
  竹内和彦,渡邉裕司
- Organizer
  第27回日本臨床薬理学会年会/P
- Place of Presentation
  東京
- Year and Date
  2006-11-30
- Data Source
  KAKENHI-PROJECT-18390074
[Presentation] Assessment of Posture- Related Dynamic Changes in Cerebral Blood Flow Using Near-Infrared Time- Resolved Spectroscopy : A New Tool To Evaluate Effects of Antihypertensives on Cerebral Circulation2006
- Author(s)
  Takeuchi K, Nakamura R, Kageyama M, Watanabe H
- Organizer
  The 79th Scientific Sessions of American Heart Association
- Place of Presentation
  Chicago(USA)
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18390074

1. HAYASHI Hideharu (50135258)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. TAKEUCHI Kazuhiko (00419425)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. SATOH Hiroshi (30293632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. TERADA Hajime (50252177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KATOH Hideki (80314029)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. MOGAMI Hideo (90311604)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Yuko (20345812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. URANO Tetsumei (50193967)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. INUI Naoki (80402254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
10. FURUTA Takahisa (10303546)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
11. OGAWA Noriyoshi (80308618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. NANBA Hiroki (60198405)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. Hayashi Toshio (80303634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. 葛谷雅文 (10283441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. CHIDA Kingo (40197611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. IKUMA Mutsuhiro (00275108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
17. NISHINO Masafumi (10436975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
18. YAMADE Mihoko (10464124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
19. IRISAWA Hiroshi (70467231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MIZUSHIMA Takashi (80279348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YAMADA Shizuo (80106434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
22. MAEKAWA Masato (20190291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
23. TERAKAWA Susumu (50014246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Odagiri Keiichi (70529213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
25. 小平知世 (40436960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 大澤恵 (10397391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. 松山幸弘 (20312316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 杉本健 (20529507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. 杉本光繁 (80397398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. 田中紫茉子 (10559925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
31. 神谷千明 (30792692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
32. 袴田晃央 (60788280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
33. 内田信也 (80372522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
34. 三坂眞元 (10583635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. WATANABE Watanabe

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. UMEMURA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

WATANABE Hiroshi 渡邉 裕司

渡邉 裕司 ワタナベ ヒロシ

渡邊 裕司 ワタナベ ヒロシ

WATANABE Hirosi 渡邉 裕司

渡邉 浩司 ワタナベ ヒロシ

渡辺 裕司 ワタナベ ヒロシ

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Clinical pharmacology study on drug-degrading esterase PON3, gene polymorphism and pharmacokinetic influencePrincipal Investigator

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WATANABE Hiroshi 渡邉裕司

渡邉裕司ワタナベヒロシ

渡邊裕司ワタナベヒロシ

WATANABE Hirosi 渡邉裕司

渡邉浩司ワタナベヒロシ

渡辺裕司ワタナベヒロシ

[Book] 今日の治療指針　2年版［ポケット判］2017

[Book] 内科学　第11版2017