TADOKORO Seiji 田所誠司

Researcher Number	80403062
Affiliation (based on the past Project Information) *help	2016: 大阪大学, 医学系研究科, 助教 2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2013 – 2014: 大阪大学, 大学院医学系研究科, 助教 2009 – 2010: Osaka University, 医学系研究科, 助教 2006 – 2008: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Hematology
Keywords	Principal Investigator インテグリン / 血小板 / シグナル伝達 / targeted therapy / cancer / platelet / signal transduction / integrin / 抗腫瘍薬 / 抗血小板薬 … More / 活性化シグナル / 分子標的治療薬 / 腫瘍 / 血栓･止血学 / 血栓止血 / α-actinin … More Except Principal Investigator 多発性骨髄腫 / インテグリン / 骨髄腫 / インテグリンαIIｂβ3 / CMK細胞 / Inside-out signaling / キンドリン / タリン / 血小板 / kindlin-3 / talin-1 / inside-out signaling / CMK / インテグリンαIIbβ3 Less

インテグリンを制御する細胞骨格蛋白ネットワークの解明と造血器腫瘍治療への応用Principal Investigator
- Principal Investigator
  
  田所誠司
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
The role of integrin alpha 8 in the pathogenesis of multiple myeloma
- Principal Investigator
  
  ICHII Michiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Analysis of regulatory molecule in platelets for thrombosis employing CMK cell system
- Principal Investigator
  
  TOMIYAMA Yoshiaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Development of new therapy based on a molecular mechanism of integrin activation signaling via integrin activation complexPrincipal Investigator
- Principal Investigator
  
  TADOKORO Seiji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Development of new therapy based on a molecular mechanism of integrin activation signaling via integrin binding proteinsPrincipal Investigator
- Principal Investigator
  
  TADOKORO Seiji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Development of new targeted therapy ford thrombosis or cancer based on a molecudar mechanism of iniegrin activation signaling.Principal Investigator
- Principal Investigator
  
  TADOKORO Seiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] 血小板インテグリンの負の調節因子2013
- Author(s)
  田所誠司, (高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編)
- Total Pages
  247
- Publisher
  Annual Review
- Data Source
  KAKENHI-PROJECT-23591416
[Book] Annual Review血液2013（高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編）2013
- Author(s)
  田所誠司
- Total Pages
  247
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591416
[Journal Article] The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.2013
- Author(s)
  Honda S, Shirotani-Ikejima H, Tadokoro S, Tomiyama Y, Miyata T.
- Journal Title
  
  PLoS One
  
  Volume: 8(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416
[Journal Article] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK2013
- Author(s)
  Nakazawa T, Tadokoro S, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Exp Hematol.
  
  Volume: 41(1) Issue: 1 Pages: 79-90
- DOI
  10.1016/j.exphem.2012.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-23591430, KAKENHI-PROJECT-23659488, KAKENHI-PROJECT-24591422
[Journal Article] Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.2012
- Author(s)
  Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.
- Journal Title
  
  Cell Death Differ.
  
  Volume: 19(11) Issue: 11 Pages: 1856-1869
- DOI
  10.1038/cdd.2012.88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24591422, KAKENHI-PROJECT-24790694
[Journal Article] Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.2012
- Author(s)
  Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Blood
  
  Volume: 120(7) Issue: 7 Pages: 1499-1509
- DOI
  10.1182/blood-2012-02-409995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-23591430, KAKENHI-PROJECT-23659488, KAKENHI-PROJECT-24591422
[Journal Article] A potential role for α-actinin in inside-out αIIbβ3 signaling.2011
- Author(s)
  Tadokoro S, et al
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in thromboxane A2 receptor.2011
- Author(s)
  Kamae T, Tadokoro S(4番目), Kanakura Y(7番目), Tomiyama Y(8番目), 他4名
- Journal Title
  
  J Thromb Haemost prepublished online
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Molecular analysis opatient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies.2011
- Author(s)
  Kashiwagi H, Tadokoro S(5番目), Kanakura Y(8番目), Tomiyama Y(9番目), 他5名
- Journal Title
  
  Int J Hematol 93
  
  Pages: 106-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor2011
- Author(s)
  Kamae T, Kiyomizu K, Nakazawa T, Tadokoro S, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 9 Issue: 5 Pages: 1040-1048
- DOI
  10.1111/j.1538-7836.2011.04245.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591242, KAKENHI-PROJECT-22390194, KAKENHI-PROJECT-23591416
[Journal Article] A potential role for α-actinin in inside-out αIIbβ3 signaling2011
- Author(s)
  Tadokoro S, Nakazawa T, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416
[Journal Article] A potential role for α-actinin in inside-out αIIbβ3 signaling.2011
- Author(s)
  Tadokoro S(1番目), Kanakura Y(7番目), Tomiyama Y(8番目), 他5名
- Journal Title
  
  Blood 117
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Molecular analysis of a patient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies.2011
- Author(s)
  Kashiwagi H, Tadokoro S, et al
- Journal Title
  
  Int J Hematol.
  
  Volume: 93 Pages: 106-111
- NAID
  10029532736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Molecular analysis of a patient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies.2011
- Author(s)
  Kashiwagi H, Kiyomizu K, Kamae T, Nakazawa T, Tadokoro S, Takiguchi S, Doki Y, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Int J Hematol
  
  Volume: 93 Pages: 106-111
- NAID
  10029532736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416
[Journal Article] Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice.2010
- Author(s)
  Kodama T, Tadokoro S(10番目), Hayashi N, 他10名
- Journal Title
  
  Gastroenterology 138
  
  Pages: 2487-2498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice.2010
- Author(s)
  Kodama T, Tadokoro S, et al
- Journal Title
  
  Gastroenterology
  
  Volume: 138 Pages: 2487-2498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Integrin-linked kinase associated with integrin activation.2009
- Author(s)
  Honda S, Tadokoro S(3番目), Tomiyama Y(6番目), 他4名
- Journal Title
  
  Blood 113
  
  Pages: 5304-5313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] 血小板インテグリンαIIbβ3活性化の細胞内メカニズム2009
- Author(s)
  田所誠司
- Journal Title
  
  日本血栓止血学会誌 20
  
  Pages: 574-581
- NAID
  10026118241
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] 変異導入法を用いた血小板インテグリンαIIbβ3の機能調節にかかわる分子の検索2009
- Author(s)
  本田繁則, 田所誠司, ら
- Journal Title
  
  日本血栓止血学会誌 20
  
  Pages: 615-621
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Integrin-linked kinase associated with integrin activation2009
- Author(s)
  本田繁則, 田所誠司, et al
- Journal Title
  
  Blood 113
  
  Pages: 5304-5313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Journal Article] Adiponectin acts as an endogenous antithrombotic factor2006
- Author(s)
  Kato, H, Tadokoro, S, et. al.
- Journal Title
  
  Arterioscler Thromb Vase Biol 26
  
  Pages: 224-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Journal Article] Critical role of ADP interaction with P2Y_<12>, receptor in the maintenance of aIIbβ3 activation : association with Rap1B activation2006
- Author(s)
  Kamae, T, Tadokoro, S, et. al.
- Journal Title
  
  J Thromb Haemost 4
  
  Pages: 1379-1387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Journal Article] Critical role of ADP interaction with P2Y_<12> receptor in the maintenance of αIIbβ3 activation: association with Rap1B activation.2006
- Author(s)
  Kamae T, Tadokoro S, et. al.
- Journal Title
  
  J Thromb Haemost 4
  
  Pages: 1379-1387
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591057
[Journal Article] Adiponectin acts as an endogenous antithrombotic factor.2006
- Author(s)
  Kato H, Tadokoro S, et. al.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 26
  
  Pages: 224-230
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591057
[Journal Article] Integrin-linked kinase associated with integrin activation
- Author(s)
  Shigenori Honda, Seiji Tadokoro, et al
- Journal Title
  
  Blood in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] ITP患者における血小板機能評価：フローサイトメトリーを用いた検討2014
- Author(s)
  柏木浩和，清水一亘，加藤　恒，田所誠司，森川陽一郎，金倉　譲，冨山佳昭
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場, 大阪
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26461402
[Presentation] インテグリンαIIbβ3機能発現におけるIntegrin-linked kinaseの役割2014
- Author(s)
  本田繁則，池島裕子，田所誠司，冨山佳昭，宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター，大阪
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-26461402
[Presentation] αIIbβ3活性化変異、αIIb(R990W)ノックインマウスは巨大血小板減少症を伴う血小板無力症様の表現型を示す2014
- Author(s)
  清水一亘，柏木浩和，國島伸治，坂野史明，森川陽一郎，加藤　恒，田所誠司，小亀浩市，本田繁則，宮田敏行，金倉　譲，冨山佳昭
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場, 大阪
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-26461402
[Presentation] インテグリンαIIbβ3活性化変異、αIIb(R990W)ノックインマウスの解析2014
- Author(s)
  清水一亘，柏木浩和，國島伸治，坂野史明，森川陽一郎，加藤　恒，田所誠司，小亀浩市，本田繁則，宮田敏行，金倉　譲，冨山佳昭
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター，大阪
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-26461402
[Presentation] αIIb(R990W), a constitutive activating mutation of integrin αIIbβ3, knock-in mice show macrothrombocytopenia with impairment of platelet function2014
- Author(s)
  Kiyomizu K, Kashiwagi H, Kunishima S, Banno F, Kato H, Morikawa Y, Tadokoro S, Kokame K, Honda S, Miyata T, Kanakura Y, Tomiyama Y
- Organizer
  The American Society of Hematology 56th Annual Meeting
- Place of Presentation
  Moscone Center, San Francisco, CA, USA
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-26461402
[Presentation] αIIbβ3細胞内活性化変異と血小板顆粒放出異常2013
- Author(s)
  柏木浩和、田所誠司、冨山佳昭、金倉譲他1名
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Year and Date
  2013-05-30
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Primary ITP患者の血小板関連抗抗体のエピトープの同定と臨床経過に関する検討2013
- Author(s)
  清水一亘、田所誠司、金倉譲、冨山佳昭他2名
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] ヒト巨核系細胞株CMKにおけるαIIbβ3の活性化にはagonist, talin-1, kindlin-3が必須である2012
- Author(s)
  中澤剛士、田所誠司、金倉譲、冨山佳昭他3名
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] α-Actinin stabilizes integrins to a low-affinity ligand-binding state in resting platelets.2011
- Author(s)
  Tadokoro S, Nakazawa T, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Identification of epitopes and critical residues for binding of platelet-associated anti-GPIIbIIIa autoantibodies in patients with chronic immune thrombocytopenia.2011
- Author(s)
  Kiyomizu K, Kashiwagi H, Nakazawa T, Kamae T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y.
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK.2011
- Author(s)
  Nakazawa T, Tadokoro S, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Tomiyama Y, Kanakura Y.
- Organizer
  Special Symposium on the Basic Science, The American Society of Hematology 53rd Annual meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK.2011
- Author(s)
  Nakazawa T, Tadokoro S, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Tomiyama Y, Kanakura Y.
- Organizer
  The American Society of Hematology 53rd Annual meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Agonist induced αIIbβ3 activation in genetically engineered human megakaryoblastic cell line, CMK.2011
- Author(s)
  Nakazawa T, Kamae T, Kiyomizu K, Tadokoro S, Honda S, Kashiwagi H, Kanakura Y, Tomiyama Y.
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Agonist induced αIIactivation in genetically engineered human megakaryocytic cell line CMK.2010
- Author(s)
  Nakazawa T, Tadokoro S(4番目), 冨山佳昭(8番目), 金倉譲(9番目), 他4名
- Organizer
  第72回日本血液学会学術集会にて発表
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] FACSにて血小板輸血の有用性を検討しえた血小板抗体を有する胃癌合併Glanzmann血小板無力症例2010
- Author(s)
  柏木浩和, 田所誠司, ら
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  城山観光ホテル(鹿児島)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] FACにて血小板輸血の有用性を検討しえた血小板抗体を有する胃癌合併Glanzman血小板無力症例2010
- Author(s)
  柏木浩和, 田所誠司(6番目), 金倉譲(9番目), 冨山佳昭(10番目), 他6名
- Organizer
  第33回日本血栓止血学会学術集会にて発表
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 血小板トロンボキサン受容体異常症患者(Nt.167-8における1塩基挿入)の血小板機能解析2010
- Author(s)
  釜江剛, 田所誠司, ら
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  城山観光ホテル(鹿児島)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Agonist induced αIIβ3 activation in genetically engineered human megakaryocytic cell line CMK.2010
- Author(s)
  Nakazawa T, Tadokoro S, et al
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Role of integrin-linked kinase in supporting integrin activation.2010
- Author(s)
  Honda S, Tadokoro S, et al
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 血小板トロンボキサン受容体異常症患者(Nt.167-8における1塩基挿入)の血小板機能解析2010
- Author(s)
  釜江剛, 田所誠司(6番目), 金倉譲(9番目), 冨山佳昭(10番目), 他6名
- Organizer
  第33回日本血栓止血学会学術集会にて発表
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in thromboxane A2 receptor.2010
- Author(s)
  Kamae T, Tadokoro S, et al
- Organizer
  The American Society of Hematology 52nd Annual meeting
- Place of Presentation
  Orange County Convention Center (USA)
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Roleof integrin-linked kinase in supportinintegrin activation.2010
- Author(s)
  本田繁則, 田所誠司(3番目), 冨山佳昭(5番目), 他3名
- Organizer
  第72回日本血液学会学術集会にて発表
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Integrin-linked kinase associated with integrin activation.2009
- Author(s)
  本田繁則, 田所誠司(3番目), 冨山佳昭(6番目), 他4名
- Organizer
  The XXII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston, USA(にて発表)
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 血小板トロンボキサン受容体異常症における新規遺伝子異常-nt.167-8における1塩基挿入-2009
- Author(s)
  釜江剛, 田所誠司, ら
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 血小板トロンボキサン受容体異常症における新規遺伝子異常.nt.167-8における1塩基挿入2009
- Author(s)
  釜江剛, 田所誠司(5番目), 金倉譲(8番目), 冨山佳昭(9番目), 他5名
- Organizer
  第71回日本血液学会学術集会にて発表
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Integrin-linked kinase associated with integrin activation2009
- Author(s)
  Honda S, Tadokoro S., et al
- Organizer
  The XXII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 変異導入法を用いたインテグリン機能発現分子の同定2008
- Author(s)
  本田繁則, 田所誠司ら
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] インテグリンαIIbβ3機能におけるP2Y12の役割-αIIbβ3とRap1活性化の同期性-2008
- Author(s)
  白鹿正通, 田所誠司ら
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] A role for α-actinin in inside-out αIIbβ3 signaling2008
- Author(s)
  Seiji Tadokoro
- Organizer
  The American Society of hematology50th Annual meeting, Special symposium
- Place of Presentation
  San Francisco U.S.A.
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 抗GPVI抗体に起因すると思われるGPVI欠損症の一例2008
- Author(s)
  秋山正夫, 田所誠司, ら
- Organizer
  第56回日本輸血・細胞治療学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-04-27
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 発現クローニング法によるインテグリン機能発現分子の同定2008
- Author(s)
  本田繁則, 田所誠司(3番目), 冨山佳昭(6番目), 他4名
- Organizer
  第31回日本血栓止血学会学術集会学術推進SPCシンポジウム
- Place of Presentation
  大阪(にて発表)
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 発現クローニングによるインテグリン機能発現分子の同定2008
- Author(s)
  本田繁則, 田所誠司ら
- Organizer
  第31回日本血栓止血学会学術集会(学術推進SPCシンポジウム)
- Place of Presentation
  大阪
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 血小板インテグリンとRap1の機能におけるP2Y12の役割2008
- Author(s)
  白鹿正通, 田所誠司ら
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 変異導入法を用いたインテグリン機能発現分子の同定2008
- Author(s)
  本田繁則, 田所誠司(2番目), 冨山佳昭(5番目), 他3名
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都(にて発表)
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] A role for α-actinin in inside-out αIIbβ3 signaling2008
- Author(s)
  Seiji Tadokoro, et al
- Organizer
  The American Society of hematology50th Annual meeting
- Place of Presentation
  San Francisco U.S.A.
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] A role for α-actinin in inside-out αIIbβ3 signaling.2008
- Author(s)
  田所誠司(1番目), 金倉譲(7番目), 冨山佳昭(8番目), 他5名
- Organizer
  The American Society of Hematology 50th Annual meeting
- Place of Presentation
  San Feancisco U.S.A.(にて発表)
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] A role for α-actinin in inside-out αIIbβ3 signaling. Special Symposium on the Basic Science of Hemostasis and Thrombosis.2008
- Author(s)
  田所誠司
- Organizer
  The American Society of Hematology 50th Annual meeting
- Place of Presentation
  San Feancisco U.S.A.(にて発表)
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] 血小板インテグリンとRap1の機能におけるP2Y12の役割2008
- Author(s)
  白鹿正通, 田所誠司(5番目), 冨山佳昭(8番目), 金倉譲(9番目), 他5名
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪(にて発表)
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] ITP合併GPVI欠損例の解析-GPVI欠損発症メカニズムに関する検討2008
- Author(s)
  秋山正夫, 田所誠司ら
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-20591152
[Presentation] Semaphorin 3A inhibits platelet function via PI3 kinase-dependent pathways2007
- Author(s)
  Akiyama M, Tadokoro S, et. al.
- Organizer
  The 5th Aso International Meeting
- Place of Presentation
  Aso, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] Talinとα-acthninによる血小板インテグリンαIIbβ3活性化調節機構の解析2007
- Author(s)
  田所誠司, ら
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会合同開催
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] Semaphorin 3A antagonizes agonist-induced PI3 kinase pathway in platelets.2007
- Author(s)
  Akiyama M, Tadokoro S, et. al.
- Organizer
  XXI Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Geneva, Switzerland
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Poster) Semaphorin 3A inhibits platelet function via PI3 kinase-dependent pathways2007
- Author(s)
  Akiyama, M, Tadokoro, S, et. al.
- Organizer
  The 5th Aso International Meeting
- Place of Presentation
  Aso, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] Talinとα-actininによる血小板インテグリンαIIbβ3活性化調節機構の解析2007
- Author(s)
  田所誠司, ら
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会合同開催
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] α-Actininによる血小板インテグリンαIIbβ3活性化制御機構の解析2007
- Author(s)
  田所誠司, ら
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Oral) A role for a-actinin in platelet integrin aIIbβ3 activation2007
- Author(s)
  Tadokoro, S, et. al.
- Organizer
  The Japanese Society on Thrombosis and Haemostasis, 30th Annual meeting
- Place of Presentation
  Mie, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] Semaphorin 3A inhibits platelet function via PI3 kinase-dependent pathways.2007
- Author(s)
  Akiyama M, Tadokoro S., et. al.
- Organizer
  The 5th Aso International Meeting
- Place of Presentation
  Aso, Japan
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Oral) Dynamic regulation of platelet integrin aIIbβ3 activation by talin and a-actinin2007
- Author(s)
  Tadokoro, S, et. al.
- Organizer
  The Japanese Society of Hematology 69th Annual meeting
- Place of Presentation
  Yokohama, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Oral) Semaphorin 3A antagonizes agonist-induced PI3 kinase pathway in platelets2007
- Author(s)
  Akiyama, M, Tadokoro, S, et. al.
- Organizer
  XXI Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Geneva, Switzerland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Poster) Roles of P2Y_<12> for integrin activation in megakaryocytic cell line, CMK2006
- Author(s)
  Shiraga, M, Tadokoro, S, et. al.
- Organizer
  The Japanese Society of Hematology 68th Annual meeting
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Poster) Molecular genetic abnormalities in Glanzmann Thrombasthenia in Japan2006
- Author(s)
  Kamae, T, Tadokoro, S, et. al.
- Organizer
  The Japanese Society of Hematology 68th Annual meeting
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] P2Y_<12>-independent transient activation and P2Y12-dependnet prolonged activation of platelet integrin αIIbβ3.2006
- Author(s)
  Shiraga M, Tadokoro S, et. al.
- Organizer
  The American Society of Hematology 48th Annual meeting
- Place of Presentation
  Orlando, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] インテグリンαIIbβ3活性化におけるP2Y_<12>の重要性-巨核球系細胞株CMKを用いた解析-2006
- Author(s)
  白鹿正通, 田所誠司, ら
- Organizer
  第68回日木血液学会総会・第48回日本臨床血液学会総会合同開催
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] 本邦における血小板無力症の遺伝子異常2006
- Author(s)
  釜江剛, 田所誠司, ら
- Organizer
  第68回日本血液学会総会・第48回日本臨床血液学会総会合同開催
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Poster) Semaphorin 3A inhibits platelet function via PI3 kinase pathways2006
- Author(s)
  Akiyama, M, Tadokoro, S, et. al.
- Organizer
  The Japanese Society of Hematology 68th Annual meeting
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] (Poster) P2Y_<12>-independent transient activation and P2Y12-dependnet prolonged activation of platelet integrin aIIbβ32006
- Author(s)
  Shiraga, M, Tadokoro, S, et. al.
- Organizer
  The American Society of Hematology 48th Annual meeting
- Place of Presentation
  Orlando, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] Semaphorin 3AはPI3 kinase系を介して血小板機能を抑制する2006
- Author(s)
  秋山正夫, 田所誠司, ら
- Organizer
  第68回日本血液学会総会・第48回日本臨床血液学会総会合同開催
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591057
[Presentation] Identification of epitopes and critical residues for binding of platelet-associated anti-GPIIbIIIa autoantibodies in patients with chronic immune thrombocytopenia
- Author(s)
  Kiyomizu K, Tadokoro S, Kanakura Y, Tomiyama Y他4名
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] ITP患者のPA anti-GPIIｂ/IIIa抗体の多くはGPIIb　βプロペラ領域の極めて限定された部位に結合する
- Author(s)
  清水一亘、柏木浩和、中澤剛士、田所誠司、本田繁則、金倉　譲、冨山佳昭
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京、ハイアットリージェンシー東京
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] ヒト巨核系細胞株CMKにおけるαIIbβ3 の活性化にはagonist, talin-1, kindlin-3が必須である。
- Author(s)
  中澤剛士、田所誠司、清水一亘、柏木浩和、本田繁則、金倉　譲、冨山佳昭
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京、ハイアットリージェンシー東京
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Platelet-associated　anti-GPIIb/IIIa　antibodies　in　primary　immune　thrombocytopenia　recognize　highly　restricted regions in the beta-propeller of GPIIb with　clonality
- Author(s)
  Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y.
- Organizer
  The 17th Congress of the European Hematology Association
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] αIIbβ3細胞内活性化変異と血小板顆粒放出異常
- Author(s)
  柏木浩和、清水一亘、田所誠司、冨山佳昭、金倉譲
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形国際ホテル（山形県）
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] Primary ITP患者の血小板関連抗αIIbβ3抗体のエピトープの同定と臨床経過に関する検討
- Author(s)
  清水一亘、柏木浩和、加藤恒、田所誠司、本田繁則、金倉譲、冨山佳昭
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形国際ホテル（山形県）
- Data Source
  KAKENHI-PROJECT-23591416
[Presentation] A　anti-GPIIb/IIIa　Abs　in　primary　ITP　recognize　highly　restricted regions in GPIIb with　clonality
- Author(s)
  Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23591416

1. TOMIYAMA Yoshiaki (80252667)

# of Collaborated Projects: 5 results

# of Collaborated Products: 41 results
2. KANAKURA Yuzuru (20177489)

# of Collaborated Projects: 5 results

# of Collaborated Products: 33 results
3. KASHIWAGI Hirokazu (10432535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ICHII Michiko (30633010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOKOSAKI Yasuyuki (80210607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤恒 (20705214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横田貴史 (60403200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 織谷健司 (70324762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TADOKORO Seiji 田所 誠司

Research Projects

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Co-Researchers

インテグリンを制御する細胞骨格蛋白ネットワークの解明と造血器腫瘍治療への応用Principal Investigator

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The role of integrin alpha 8 in the pathogenesis of multiple myeloma

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Analysis of regulatory molecule in platelets for thrombosis employing CMK cell system

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Development of new therapy based on a molecular mechanism of integrin activation signaling via integrin activation complexPrincipal Investigator

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Development of new therapy based on a molecular mechanism of integrin activation signaling via integrin binding proteinsPrincipal Investigator

Principal Investigator

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Development of new targeted therapy ford thrombosis or cancer based on a molecudar mechanism of iniegrin activation signaling.Principal Investigator

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[Book] 血小板インテグリンの負の調節因子2013

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[Book] Annual Review血液2013（高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編）2013

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[Journal Article] The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.2013

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[Journal Article] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK2013

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DOI

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[Journal Article] Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.2012

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DOI

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[Journal Article] Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.2012

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DOI

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[Journal Article] A potential role for α-actinin in inside-out αIIbβ3 signaling.2011

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[Journal Article] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in thromboxane A2 receptor.2011

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[Journal Article] Molecular analysis opatient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies.2011

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TADOKORO Seiji 田所誠司