TAKAHASHI Kanako 高橋加奈子

Researcher Number	80403715
External Links
Affiliation (based on the past Project Information) *help	2015: 徳島大学, 大学院医歯薬学研究部, 助教 2015: 徳島大学, 病院, 特任講師 2014 – 2015: 徳島大学, 大学病院, 特任講師 2014: 徳島大学, 大学病院, 講師 2012 – 2013: 徳島大学, ヘルスバイオサイエンス研究部, 助教 … More 2007 – 2012: The University of Tokushima, Institute of Health Boisciences, Graduate School, Assistant professor 2009: 徳島大学, 大学院・ヘルスバイオサイェンス研究部, 助教 2007 – 2008: 徳島大学, 医学部・歯学部附属病院, 助教 2006: Tokushima University, Hospital, Research Associate, 医学部・歯学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Conservative dentistry Except Principal Investigator Conservative dentistry / Periodontal dentistry
Keywords	Principal Investigator 歯髄炎 / 自然免疫 / 免疫応答 / Alarmin / 感染症 / 象牙芽細胞 / 抗菌因子 / 細菌性因子 / リンパ球浸潤 / ケモカイン … More Except Principal Investigator … More 象牙細管 / フッ化ジアンミン銀 / フッ化ジアミンシリケート / フッ素 / 齲蝕 / 抗菌成分 / 象牙質知覚過敏症 / MMP / JAM-A / cadherin / claudin / adherence junction / 歯周病 / Bacterial Infection / 細菌感染 / 共培養 / シグナル伝達 / クローディン / 上皮細胞 / 線維芽細胞 / S. mutans / 塩化セチルピリジニウム / ハイドロキシアパタイト / フッ化カルシウム / シリカ / periodontal disease / epithelial cell / fight iunction / トランスフェクション / tight-junction / タイトジャンクション / tight junction / Immune Reaction / Gene_Expression / Macrophage / Inflammation / Periodontopathogen / Atherosclerosis / Periodontal Disease / スカベンジャーレセプター / 炎症性サイトカイン / 免疫応 / 遺伝子発現 / マクロファージ / 炎症 / 歯周病関連細菌 / 動脈硬化症 / Specific Gene Sequence / Gene Amplification / Refractory case / Periapical Periodontitis / 特異的遺伝子配列 / 遺伝子増幅 / 難治症例 / 根尖性歯周炎 / dentin tubule / calcium phosphate / silica / dental caries / dentin hypersensitivity / fluoride / diamine silver fluoride / ammonium hexafluorosilicate / 象牙細管内液 / 象牙質透過性 / 人工唾液 / 操作型電子顕微鏡 / イヌ生活歯 / リン酸カルシウム / 象牙質 / グルコン酸クロルヘキシジン / 酸蝕歯 / 抗菌性 / サホライド / 歯学 / 酸蝕症 / オクルーディン / ケモカイン / 歯周炎 / 齲蝕予防 / 粉末Ｘ線回折 / スメア層 / クオラムセンシング / バイオフィルム / 齲蝕原性細菌 / 象牙質齲蝕 / エナメル質 / アパタイト Less

歯髄炎の発症および進行における生体防御機構の解明Principal Investigator
- Principal Investigator
  
  高橋加奈子
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Development of the method for prevention of dental caries with antibacterial ammonium hexafluorosilicate
- Principal Investigator
  
  SUGE Toshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
The analyses of the immune system of odontoblast in the pathogenesis of pulpitisPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Kanako
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
歯周病変に発現するクローディンとケモカインによる歯周病原因子の上皮透過性制御機構
- Principal Investigator
  
  中江英明
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Development of the method for prevention of dental caries with antibacterial ammonium hexafluorosilicate
- Principal Investigator
  
  SUGE Toshiyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
The analyses of release and production of Alarmin in the pathogenesis of pulpitisPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Kanako
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
The analysis of innate immunity system in the pathogenesis of pulpitis.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Kanako
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Development of treatment method for the prevention of dental caries and dentin hypersensitivity with ammonium hexafluorosilicate
- Principal Investigator
  
  SUGE Toshiyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Study of quorum-sensing system of invading bacteria in dentinal caries
- Principal Investigator
  
  OZAKI Kazumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
歯髄炎の病態形成におけるリンパ球浸潤機構の解析Principal Investigator
- Principal Investigator
  
  高橋加奈子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Analysis of bacterial invasive lesion of refractory periapical periodontitis cases by genetic engineering technique
- Principal Investigator
  
  MATSUO Takashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
Clarification of the mechanism of periodontitis-initiated/accelerated atheroacleicsis and identification of its causal components
- Principal Investigator
  
  YUMOTO Hiromichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Analysis of the mechanisms that claudins expressed in periodontal diseased epithelium regulate the permeability of gingival epithelium
- Principal Investigator
  
  NAKAD Hideaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  The University of Tokushima
Development of treatment method for prevention of dental caries and dentin hypersensitivity with silica-fluoride compound
- Principal Investigator
  
  SUGE Toshiyuki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima

All 2015 2014 2013 2010 2009 2008 2006 Other

All Journal Article Presentation

[Journal Article] Electromagnetic wave irradiation promotes osteoblastic cell proliferation and up-regulates growth factor via activation of the ERK1/2 and p38 MAPK pathways2015
- Author(s)
  Yumoto H, Hirao K, Tominaga T, Bando N, Takahashi K, Matsuo T
- Journal Title
  
  Cellular Physiology and Biochemistry
  
  Volume: 35 Pages: 601-605
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592870
[Journal Article] Modulatory roles of interferon-γ through indoleamine 2, 3-dioxygenase induction in innate immune response of dental pulp cells2014
- Author(s)
  Takegawa D, Nakanishi T, Hirao K, Yumoto H, Takahashi K, Matsuo T
- Journal Title
  
  Journal of Endodontics
  
  Volume: 40 Pages: 1382-1387
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592870
[Journal Article] Effect of extracellular DNA and DNA-binding protein on the development of a Streptococcus intermedius biofilm2013
- Author(s)
  Nur A, Hirota K, Yumoto H, Hirao K, Liu D, Takahashi K, Murakami K, Matsuo T, Shu R, Miyake Y
- Journal Title
  
  Journal of Applied Microbiology
  
  Volume: 115 Pages: 260-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592870
[Journal Article] 歯髄疾患の病態と診断2013
- Author(s)
  松尾敬志, 中西正, 湯本浩通, 高橋加奈子, 平尾功治, 武川大輔
- Journal Title
  
  日本歯内療法学会雑誌
  
  Volume: ３４ Pages: 67-76
- NAID
  10031183916
- Data Source
  KAKENHI-PROJECT-24592870
[Journal Article] 培養歯髄細胞におけるStreptococcus mutansおよび炎症性サイトカインによるCCL20の発現2010
- Author(s)
  高橋加奈子
- Journal Title
  
  四国歯学会雑誌
  
  Volume: 22(2) Pages: 157-165
- NAID
  120005823503
- Data Source
  KAKENHI-PROJECT-22791838
[Journal Article] Tea catechins reduce inflammatory reaction via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells2010
- Author(s)
  Hirao K, Yumoto H, Nakanishi T, Mukai K, Takahashi K, Takegawa D, Matsuo T
- Journal Title
  
  Life Sciences
  
  Volume: 86 Issue: 17-18 Pages: 654-660
- DOI
  10.1016/j.lfs.2010.02.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791838
[Journal Article] Roles of TLR2, TLR4, NOD2 and NOD1 in pulp fibroblasts2009
- Author(s)
  Hirao K, Yumoto H, Takahashi K, Mukai K, Nakanashi T, Matsuo T
- Journal Title
  
  J Dent Res 88(8)
  
  Pages: 762-767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791386
[Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines2008
- Author(s)
  KANAKO TAKAHASHI, et.al.
- Journal Title
  
  Oral Microbiology Immunology 23
  
  Pages: 320-327
- NAID
  120005823503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791386
[Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines2008
- Author(s)
  Takahashi K, Nakanishi T, Yumoto H, Adachi T, Matsuo T
- Journal Title
  
  Oral Microbial Immunol 23(4)
  
  Pages: 320-32
- NAID
  120005823503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791386
[Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and pro-inflammatory cytokines2008
- Author(s)
  Kanako, Takahashi, et. al.
- Journal Title
  
  Oral Microbiology and Immunology (In press)
- NAID
  120005823503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592092
[Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and pro-inflammatory cytokines.2008
- Author(s)
  KANAKO TAKAHASHI, et. al.
- Journal Title
  
  Oral Microbiology and Immunology
- NAID
  120005823503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592092
[Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and pro-inflammatory cytokines.2008
- Author(s)
  KANAKO TAKAHASHI, et. al.
- Journal Title
  
  Oral Microbiology and Immunology (In press)
- NAID
  120005823503
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592092
[Journal Article] Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells.2006
- Author(s)
  YUSUKE TAKAHASHI et al.
- Journal Title
  
  Cellular Microbiology 8・5
  
  Pages: 738-757
- Data Source
  KAKENHI-PROJECT-18592263
[Journal Article] Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells2006
- Author(s)
  Yusuke, Takahashi, et. al.
- Journal Title
  
  Cellular Microbiology 8
  
  Pages: 738-757
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592263
[Journal Article] Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells.2006
- Author(s)
  YUSUKE TAKAHASHI, et. al.
- Journal Title
  
  Cellular Microbiology 8-5
  
  Pages: 738-757
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592263
[Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans, pro-inflammatory cytokines
- Author(s)
  KANAKO TAKAHASHI, et. al.
- Journal Title
  
  Oral Microbiology, Immunology (In press)
- NAID
  120005823503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791403
[Presentation] Streptococcus intermediusヒストン様タンパク質のPAMPSとしての解析2013
- Author(s)
  弘田克彦, 湯本浩通, 村上圭史, 平尾功治, 高橋加奈子, 松尾敬志, 三宅洋一郎
- Organizer
  第22回Lancefieldレンサ球菌研究会＆第45回レンサ球菌感染症研究会
- Place of Presentation
  ホテル島根イン青山パインコートI・II（東京都）
- Data Source
  KAKENHI-PROJECT-24592870
[Presentation] Homologous and heterologous extracellular DNAs affect Pseudomonas aeruginosa to produce more pyocyanin without inducing bacterial growth2013
- Author(s)
  Asikin Nur, Katsuhiko Hirota, Hiromichi Yumoto, Kouji Hirao, Kanako Takahashi, Keiji Murakami and Yoichiro Miyake
- Organizer
  第66回日本細菌学会中国・四国支部総会
- Place of Presentation
  広島国際大学メディアホール（広島県）
- Data Source
  KAKENHI-PROJECT-24592870
[Presentation] 培養歯髄細胞におけるAlarminの産生・放出機構の解析2010
- Author(s)
  高橋加奈子, 他
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20791386
[Presentation] 炎症性サイトカインやPAMP刺激によるヒト培養歯髄細胞におけるAlarminの産生・放出2009
- Author(s)
  高橋加奈子, 他
- Organizer
  第131回日本歯科保存学会秋季学術大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-20791386
[Presentation] 炎症性サイトカインやPAMP刺激によるヒト培養歯髄細胞におけるAlamlinの産生・放出2009
- Author(s)
  高橋加奈子, 他
- Organizer
  第131回日本歯科保存学会秋季学術大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-20791386
[Presentation] ラット象牙芽細胞様細胞（KN3）における細菌関連病原因子刺激に対する自然免疫反応の解析
- Author(s)
  平尾功治, 湯本浩通, 中西正, 篠原千尋, 高橋加奈子, 武川大輔, 細川由樹, 松尾敬志
- Organizer
  第140回　日本歯科保存学会
- Place of Presentation
  滋賀県立芸術劇場びわ湖ホール(滋賀県大津市）
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24592870
[Presentation] Effect of extracellular DNA on pyocyanin production from Pseudomonas aeruginosa
- Author(s)
  Asikin Nur, Katsuhiko Hirota, Hiromichi Yumoto, Kouji Hirao, Kanako Takahashi, Keiji Murakami, Takashi Matsuo and Yoichiro Miyake
- Organizer
  第27回Bacterial Adherence&biofilm学術集会
- Place of Presentation
  東京ガーデンパレス（東京都）
- Data Source
  KAKENHI-PROJECT-24592870
[Presentation] イグサ抽出液のオーラルヘルスケア製品への応用に関する研究
- Author(s)
  細川由樹, 湯本浩通, 平尾功治, 高橋加奈子, 松尾敬志
- Organizer
  第141回　日本歯科保存学会
- Place of Presentation
  山形県山形市　山形テルサ
- Year and Date
  2014-10-30 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24592870

1. SUGE Toshiyuki (60243713)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. YUMOTO Hiromichi (60284303)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
3. NAKAE Hideaki (30227730)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. ISHIKAWA Kunio (90202952)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. OZAKI Kazumi (90214121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKAMATSU Natsuko (90403716)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HIRAO Kouji (00581399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. HOSOKAWA Ikuko (50707908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUO Takashi (30173800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKANISHI Tadashi (00217770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIDA Yoshiko (20243727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 川崎有希子 (60294708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Kanako 高橋 加奈子

Research Projects

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Co-Researchers

歯髄炎の発症および進行における生体防御機構の解明Principal Investigator

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The analyses of the immune system of odontoblast in the pathogenesis of pulpitisPrincipal Investigator

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The analyses of release and production of Alarmin in the pathogenesis of pulpitisPrincipal Investigator

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The analysis of innate immunity system in the pathogenesis of pulpitis.Principal Investigator

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歯髄炎の病態形成におけるリンパ球浸潤機構の解析Principal Investigator

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[Journal Article] Electromagnetic wave irradiation promotes osteoblastic cell proliferation and up-regulates growth factor via activation of the ERK1/2 and p38 MAPK pathways2015

TAKAHASHI Kanako 高橋加奈子