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Hirota Takeshi  廣田 豪

… Alternative Names

HIROTA Takeshi  廣田 豪

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Researcher Number 80423573
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4846-3421
Affiliation (Current) 2022: 九州大学, 大学病院, 副薬剤部長
Affiliation (based on the past Project Information) *help 2021 – 2022: 九州大学, 大学病院, 副薬剤部長
2016 – 2020: 九州大学, 薬学研究院, 准教授
2016: 九州大学, 薬学研究科(研究院), 准教授
2011 – 2016: 九州大学, 薬学研究科(研究院), 助教
2014: 九州大学, 薬学研究院・薬物動態学分野, 助教 … More
2013: 九州大学, 大学院・薬学研究院, 助教
2010 – 2012: Kyushu University, 薬学研究院, 助教
2007 – 2010: Kyushu University, 大学院・薬学研究院, 助教
2006: 九州大学, 大学院薬学研究院, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Applied pharmacology / Basic Section 47060:Clinical pharmacy-related
Except Principal Investigator
Medical pharmacy / Applied pharmacology / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
microRNA / 発現制御 / バイオマーカー / 薬物トランスポーター / 薬剤反応性 / Pharmacogenomics / MDR1 / miRNA / SNPS / pharmacogenetics … More / inter-individual variability / エピジェネティクス / 薬物代謝酵素 / オーダーメード医療 / クルクミン / P糖タンパク質 / インスリン / 薬物動態予測 / エクソソーム / 生活習慣病 / 糖尿病 / 薬物動態 … More
Except Principal Investigator
miRNA / CYP3A4 / 薬剤反応性 / MDR1 / 発現制御 / 遺伝子 / 個人差解明 / コヒーシンモデル / DNAメチル化 / バイオマーカー / 薬物トランスポーター / コピーナンバー多型 / インプリンティング / SNPs / エピジェネティックス / 薬物動態 / コピー数多型 / CNV / PK / PD遺伝子 / 肺癌 / メトトレキセート / DHFR / 血球中内活性 / MTX / グルタミン付加体 / トランスポーター遺伝子 / 遺伝子多型 / 遺伝子空間的転写モデル / 臨床試験 / 立体空間的発現制御 / メチル化 / CpGアイランド / オーダーメード医療 / DMR / コヒーシン / microRNA / P-gp / p-糖タンパク質 / 転写制御 / 抗がん剤 / 耐性克服 / ゲノム / 薬剤応答性 / 活性評価 / 生体試料中濃度 / トランスポーター / 薬物代謝酵素 / 個別化医療 / メタボローム解析 / 臨床応用 / RNAメチル化 / エピトランスクリプトーム解析 / 生活習慣病 / 高血糖 / 発現変動機構 / 臓器特異的 / 体内動態変動 / 薬効動態変動 / TDM / 治療薬物モニタリング / 血漿中miRNA / 個別化 / 精度向上 Less
  • Research Projects

    (18 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (3 People)
  •  体液中臓器特異的miRNAに注目した病態時における体内・薬効動態変動の機序解明

    • Principal Investigator
      家入 一郎
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyushu University
  •  血漿中miRNA情報を付加した治療薬物モニタリングの個別化精度向上を目指す新展開

    • Principal Investigator
      家入 一郎
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kyushu University
  •  生活習慣病に伴う薬物動態変動を反映したバイオマーカーの定量的モデル解析Principal Investigator

    • Principal Investigator
      廣田 豪
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyushu University
  •  Mechanism of regulation of drug transporter expression in lifestyle-related diseases by epitranscriptomics

    • Principal Investigator
      Ieiri Ichiro
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kyushu University
  •  Elucidation of the mechanism of insulin-induced changes in the expression of drug transporters and the establishment of a method to predict the changes in genetic functionPrincipal Investigator

    • Principal Investigator
      Hirota Takeshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyushu University
  •  Evaluation between CYP3A4 activity and DNA methylation

    • Principal Investigator
      Ieiri Ichiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyushu University
  •  Analysis of miRNA as a novel biomarker for estimating transporter's function in the human organs

    • Principal Investigator
      Ieiri Ichiro
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  DNA methylation biomarkers for estimation of the activity of CYP3A4 in human livers

    • Principal Investigator
      Ieiri Ichiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyushu University
  •  Identification of endogenous biomarkers to predict the altered activities of drug transporters by environmental factorsPrincipal Investigator

    • Principal Investigator
      Hirota Takeshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  The role of miR-27a in regulation of P-gp expression

    • Principal Investigator
      IEIRI Ichiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  Analysis of cohesin model in CYP3A4 gene and individual phenotypic status

    • Principal Investigator
      IEIRI ICHIRO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  Biomarker strategies using blood microRNA to predict pharmacokineticsPrincipal Investigator

    • Principal Investigator
      HIROTA TAKESHI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  Cohesin-dependentregulation of the expression of drug transporter genes

    • Principal Investigator
      IEIRI Ichiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  Epigenetic regulation of CYP3A4 gene and individual phenotypic statusPrincipal Investigator

    • Principal Investigator
      HIROTA Takeshi
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  Investigation of clinical impacts of CNV in the pharmacokinetic-related genes

    • Principal Investigator
      IEIRI Ichiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  薬物トランスポーター遺伝子情報を駆使したリウマチ治療薬の個別適正化使用

    • Principal Investigator
      家入 一郎
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  Alternative mechanisms of gene regulation for pharmacokinetics related genes

    • Principal Investigator
      HIGUCHI Shun
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  ヒトMDR1遺伝子機能の制御を目指したmiRNA機能解析Principal Investigator

    • Principal Investigator
      廣田 豪
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University

All 2021 2020 2018 2016 2015 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Patent

  • [Journal Article] Effect of Curcumin on Sulfasalazine Pharmacokinetics in Healthy Volunteers2016

    • Author(s)
      Tomoko Tokumoto, Takeshi Hirota, Keisuke Gotanda, Miyuki Kimura, Shin Irie, Masato Fukae and Ichiro Ieiri
    • Journal Title

      Journal of Drug Metabolism & Toxicology

      Volume: 7 Pages: 1000206-1000206

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460199
  • [Journal Article] Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines2016

    • Author(s)
      Gotanda K, Hirota T, Saito J, Fukae M, Egashira Y, Izumi N, Deguchi M, Kimura M, Matsuki S, Irie S, Ieiri I
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 32299-32299

    • DOI

      10.1038/srep32299

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460199, KAKENHI-PROJECT-15K15004
  • [Journal Article] Sulfasalazine disposition in subject with 376C>T (nonsense mutation) and 421C>A variants in ABCG2 gene.2015

    • Author(s)
      Gotanda K, Tokumoto T, Hirota T, Fukae M, Ieiri I.
    • Journal Title

      British Journal of Clinical Pharmacology

      Volume: 未定 Pages: 1236-1237

    • DOI

      10.1111/bcp.12654

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460199, KAKENHI-PROJECT-15J00726
  • [Journal Article] Association between DNA methylation in the miR-328 5'-flanking region and inter-individual differences in miR-328 and BCRP expression in human placenta2013

    • Author(s)
      Saito J, Hirota T, Furuta S, Kobayashi D, Takane H, Ieiri I
    • Journal Title

      PLoS One

      Volume: 21;8(8)

    • DOI

      10.1371/journal.pone.0072906

    • Data Source
      KAKENHI-PROJECT-23590186
  • [Journal Article] Association between DNA methylation in the miR-328 5'-flanking region and inter-individual differences in miR-328 and BCRP expression in human placenta2013

    • Author(s)
      Saito J, Hirota T, Furuta S, Kobayashi D, Takane H, Ieiri I.
    • Journal Title

      PLoS One

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590186
  • [Journal Article] Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: relationship to epigenetic variations in the 5'-upstream regulatory region2011

    • Author(s)
      Saito J, Hirota T, Kikunaga N, Otsubo K, Ieiri I
    • Journal Title

      Journal of pharmaceutical sciences

      Volume: 100(9) Pages: 3875-83

    • DOI

      10.1002/jps.22595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659083
  • [Journal Article] Interindividual differences in placental expression of the SLC22A2(OCT2)gene: Relationship to epigenetic variations in the 5'-upstream regulatory region.Journal of Pharmaceutical Sciences2011

    • Author(s)
      Saito J, Hirota T, Kikunaga N, Otsubo K, Ieiri I.
    • Journal Title

      Epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790151
  • [Journal Article] Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.2011

    • Author(s)
      Sasaki T, Hirota T, Ryokai Y, Kobayashi D, Kimura M, Irie S, Higuchi S, Ieiri I.
    • Journal Title

      Drug Metab Pharmacokinet. Apr22

    • NAID

      130004463197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390048
  • [Journal Article] Novel large-scale deletion (whole exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome.2009

    • Author(s)
      Kanda D, Takagi H, Kawahara Y, Yata Y, Takakusagi T, Hatanaka T, Yoshinaga T, Iesaki K, Kashiwabara K, Higuchi T, Mori M, Hirota T, Higuchi S, Ieiri I.
    • Journal Title

      Drug Metab Pharmacokinet. 24(5)

      Pages: 464-468

    • NAID

      130004463097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390048
  • [Journal Article] Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters;DNA methylation and other mechanisms.2008

    • Author(s)
      Hirota, T・Takane, H・Higuchi, S・Ieiri I.
    • Journal Title

      Current Drug Metabolism 9(1)

      Pages: 34-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790122
  • [Patent] DNAメチル化解析方法ならびにCYP3A4発現量推定方法2018

    • Inventor(s)
      家入一郎、廣田 豪
    • Industrial Property Rights Holder
      国立大学法人九州大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Data Source
      KAKENHI-PROJECT-17H04103
  • [Presentation] リキッドバイオプシーを用いた薬物動態個人差の予測とテーラーメイド医療への応用2021

    • Author(s)
      廣田 豪
    • Organizer
      第28回HAB研究機構学術年会
    • Data Source
      KAKENHI-PROJECT-20H03405
  • [Presentation] RNA メチル化解析による高血糖時のトランスポーター発現変動メカニズムの解明2021

    • Author(s)
      廣田 豪, 香川 竜希, 家入 一郎
    • Organizer
      第9回日本くすりと糖尿病学会
    • Data Source
      KAKENHI-PROJECT-20H03405
  • [Presentation] リキッドバイオプシーを用いたエピジェネティクス解析の薬物動態個人差予測への応用2021

    • Author(s)
      廣田 豪, 家入 一郎
    • Organizer
      第5回日本臨床薬理学会 九州・沖縄地方会
    • Data Source
      KAKENHI-PROJECT-20H03405
  • [Presentation] RNAメチル化解析による糖尿病発症時のトランスポーター発現変動メカニズムの解明2020

    • Author(s)
      香川竜希, 清田将裕, 小野未央里, 廣田豪, 家入一郎
    • Organizer
      第41回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K22502
  • [Presentation] ABCG2遺伝子376C>T変異がスルファサラジンの体内動態に与える影響2016

    • Author(s)
      廣田豪、五反田圭介、徳本知子、深江真登、家入一郎
    • Organizer
      日本薬物動態学会 第31回年会
    • Place of Presentation
      長野県松本市
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K15004
  • [Presentation] Sulfasalazine disposition in subject with 376C>T (nonsense mutation) variant in ABCG2 gene2016

    • Author(s)
      Takeshi Hirota, Keisuke Gotanda, Tomoko Tokumoto, Masato Fukae and Ichiro Ieiri
    • Organizer
      International Society for the Study of Xenobiotics
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2016-06-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460199
  • [Presentation] ABCG2遺伝子376C>T変異がスルファサラジンの体内動態に与える影響2016

    • Author(s)
      廣田豪、五反田圭介、徳本知子、深江真登、家入一郎
    • Organizer
      日本薬物動態学会 第31回年会
    • Place of Presentation
      長野県松本市
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26460199
  • [Presentation] miR-27a 374aによるP-gpの発現制御機構の解明2015

    • Author(s)
      水永 茉梨, 廣田 豪, 安井 俊貴, 山口 晃平, 家入 一郎
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26
    • Data Source
      KAKENHI-PROJECT-25670078
  • [Presentation] クルクミンが消化管BCRP発現へ与える影響評価2015

    • Author(s)
      徳本 知子, 廣田 豪, 五反田 圭介, 深江 真登, 家入 一郎
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26
    • Data Source
      KAKENHI-PROJECT-26460199
  • [Presentation] ヒトCYP3A4 遺伝子発現のゲノム空間構造解析に基づく個人差解明2013

    • Author(s)
      江口 駿介, 廣田 豪, 舞 彩華, 家入一郎
    • Organizer
      日本薬学会 第133年会
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23390035
  • [Presentation] マイクロRNAによる薬物トランスポーターの発現制御とその機能予測バイオマーカーとしての可能性2013

    • Author(s)
      廣田豪、家入一郎
    • Organizer
      第30回日本TDM学会・学術大会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23590186
  • [Presentation] エピジェネティック制御機構に基づくCYP3A4遺伝子発現制御メカニズムの解析2013

    • Author(s)
      藤田 麻里絵、江口 駿介、廣田 豪、家入 一郎
    • Organizer
      第30回日本薬学会九州支部大会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-23390035
  • [Presentation] エピジェネティック制御機構に基づくCYP3A4 遺伝子発現制御メカニズムの解析2013

    • Author(s)
      藤田 麻里絵, 江口 駿介, 廣田 豪, 家入 一郎
    • Organizer
      第30回日本薬学会九州支部大会
    • Year and Date
      2013-12-08
    • Data Source
      KAKENHI-PROJECT-23390035
  • [Presentation] マイクロRNAによる薬物トランスポーターの発現制御とその機能予測バイオマーカーとしての可能性2013

    • Author(s)
      廣田豪, 家入一郎
    • Organizer
      第30回日本TDM学会・学術大会
    • Year and Date
      2013-05-25
    • Data Source
      KAKENHI-PROJECT-23590186
  • [Presentation] ヒトCYP3A4遺伝子発現のゲノム空間構造解析に基づく個人差解明2013

    • Author(s)
      江口駿介、廣田豪、舞彩華、家入一郎
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23659083
  • [Presentation] ヒトmiR-328発現に個体間変動をもたらすメカニズムの解明2012

    • Author(s)
      齋藤順平, 廣田豪, 古田真士, 家入一郎
    • Organizer
      第11回次世代を担う若手ファーマ・バイオフォーラム
    • Place of Presentation
      岩手
    • Year and Date
      2012-09-15
    • Data Source
      KAKENHI-PROJECT-23590186
  • [Presentation] DNAメチル化によるヒトmiR-328発現制御機構の解明2012

    • Author(s)
      古田真士, 齋藤順平, 廣田豪, 家入一郎
    • Organizer
      第29回日本薬学会九州支部大会
    • Year and Date
      2012-12-09
    • Data Source
      KAKENHI-PROJECT-23590186
  • [Presentation] DNA METHYLATION REGULATES miR-328 EXPRESSION WHICH IS ASSOCIATED WITH INTER-INDIVIDUAL DIFFERENCES IN BCRP EXPRESSION IN HUMAN PLACENTA2012

    • Author(s)
      齋藤順平, 廣田豪, 古田真士, 家入一郎
    • Organizer
      日本薬物動態学会第27回年会
    • Year and Date
      2012-11-22
    • Data Source
      KAKENHI-PROJECT-23590186
  • [Presentation] CYP3A4 遺伝子発現の個人差解明を指向したエピジェネティック解析2011

    • Author(s)
      江口 駿介, 廣田 豪, 家入 一郎
    • Organizer
      第28回日本薬学会九州支部大会
    • Year and Date
      2011-12-10
    • Data Source
      KAKENHI-PROJECT-23390035
  • [Presentation] Ichiro Ieiri Imprinting Analysis of OCTs Genes in Human Placenta2010

    • Author(s)
      Junpei Saitoh, Takeshi Hirota, Naomi Kikunaga
    • Organizer
      18^th International Symposium on Microsomes and Drug Oxidations
    • Place of Presentation
      Beijing, China
    • Data Source
      KAKENHI-PROJECT-21790151
  • [Presentation] 薬物動態関連遺伝子のCopy Number Variation解析とその活用における留意点日本薬学会2009

    • Author(s)
      家入一郎、木下智広、廣田豪、安東幸恵、樋口駿
    • Organizer
      第129回年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20390048
  • [Presentation] Determination of CYP2D6 copy number variation by real-time quantitative PCR in Japanese.2008

    • Author(s)
      安東幸恵, 木下智広, 廣田豪, 樋口駿, 家入一郎
    • Organizer
      2^<nd> Asian Pacific ISSX Regional Meeting
    • Place of Presentation
      School of pharmacy, Fudan University
    • Year and Date
      2008-05-13
    • Data Source
      KAKENHI-PROJECT-20390048
  • [Presentation] Real Time PCR法を用いた薬物動態関連遺伝子のCopy Number Variation (CNV)解析2008

    • Author(s)
      木下智広、廣田豪、安東幸恵、家入一郎、樋口駿
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学薬学部
    • Year and Date
      2008-12-07
    • Data Source
      KAKENHI-PROJECT-20390048
  • 1.  IEIRI Ichiro (60253473)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 20 results
  • 2.  HIGUCHI Shun (40218699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  田畑 香織 (90464388)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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