SHIMIZU SHUJI 清水秀二

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Shimizu Shuji 清水秀二

SHIMIZU Shuji 清水秀二

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Researcher Number	80443498
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2019 – 2020: 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 上席研究員 2015 – 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 研究員 2016: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 … More 2016: 独立行政法人国立循環器病研究センター, 循環動態制御部, 上級研究員 2013: 国立循環器病研究センター, 研究所, 特任研究員 2012 – 2013: 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 2010 – 2011: 独立行政法人国立循環器病研究センター, 循環動態制御部, 特任研究員 2009: 国立循環器病センター研究所, 循環動態機能部, 派遣研究員 2008: 国立循環器病センター(研究所), 循環動態機能部, 派遣研究員 2007: 国立循環器病センター研究所, 循環動態機能部, 派遣研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 55030:Cardiovascular surgery-related / Cardiovascular medicine / Thoracic surgery Except Principal Investigator Basic Section 55030:Cardiovascular surgery-related / Basic Section 55060:Emergency medicine-related / Biomedical engineering/Biological material science / Basic Section 90130:Medical systems-related / Emergency medicine / Anesthesiology/Resuscitation studies / Basic Section 90110:Biomedical engineering-related / Cardiovascular medicine
Keywords	Principal Investigator 血行動態 / シミュレーション / 先天性心疾患 / 植込み型補助人工心臓 / 植え込み型補助人工心臓 / ベッドサイド / α2アドレナリン受容体作動薬 / 心臓迷走神経 / 心臓交感神経 / デクスメデトミジン … More / α２アドレナリン受容体作動薬 / 心不全 / 心臓血管外科 / トレーニング / 胸部大動脈瘤 / シミュレータ / ステントグラフト / 心臓血管外科学 … More Except Principal Investigator 心不全 / 全ゲノム解析 / ゲノム解析 / 心移植 / 心停止ドナー / 心筋保護 / 心臓移植 / フォンタン循環 / ミオグロビン / 心筋粘弾性 / マイクロダイアリシス法 / 虚血・再灌流 / 心臓 / 迷走神経 / 心臓力学 / 制御工学 / 循環器 / 有効循環血液量 / Cardiac surgery / Etiological Analysis / NG sequencer / Whole genome sequence / TAPVC / 原因遺伝子 / 肺静脈狭窄予防 / トリオ解析 / 総肺静脈還流異常症 / タイチン / 心臓エナジェティクス / 心筋虚血 / 完全大血管転位症 / 先天性心疾患 / シングルセル解析 / 心臓手術 / 肺静脈狭窄 / 総肺静脈環流異常症 / 純型肺動脈閉鎖症 / 体外式搬送システム / 心機能評価 / 補助循環 / 右心不全 / 右心補助 / フォンタン不全 / β3アドレナリン受容体 / カテコラミン / β3受容体作動薬 / 心筋虚血再灌流障害 / 心筋虚血再還流障害 / β３受容体作動薬 / 心臓マイクロダイアリシス / 心虚血・再灌流 / モノアミンオキシダーゼ / ヒドロキシラジカル / モノアミン / 循環調節 / バイオメカニクス / 虚血心 / 心筋特性 / 拡張不全 / 収縮不全 / 循環動態 / 拡張特性 / 収縮特性 / 心機能 / Acute Myocardinal Infarction / Ventricular Remodeling / Cardiac Matrix Metalloproteinase / Vagal Nerve / Cardiac Oxigen Metabolism / Hemodynamics / Heart Failure / Automated control / 心臓間質酵素 / 心拡大 / 心臓酸素消費量 / 急性心筋梗塞 / 心室リモデリング / 心筋組織間質蛋白分解酵素 / 心臓酸素代謝 / 血行動態 / 自動制御 / 5-HIAA / セロトニン / 高血圧 / 動脈圧反射 / メデトミジン / システム生理学 / 生理学 / 薬理学 / 循環器・高血圧 / 循環生理学 / 循環器病学 / 医療・福祉 / 輸液療法 / 周術期管理 / 血行動態モデル / 血行動態管理 / 循環系平均充満圧 / オンラインシステム同定 / マクロ血行動態モデル / システム同定 / 自動治療 / リエントリ / 蛍光計測 / 心室細動 / シミュレーション / 不整脈 Less

Exploration of Therapeutic Targets for the Prevention of Pulmonary Vein Stenosis Following Surgical Repair of Total Anomalous Pulmonary Venous Connection
- Principal Investigator
  
  枝木大治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Okayama University
Identification of the gene responsible for transposition of the great arteries
- Principal Investigator
  
  加藤源太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Okayama University
フォンタン循環不全に対する最適な左心補助循環の検討
- Principal Investigator
  
  小谷恭弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Okayama University
Approach to the Development of New Therapeutic Agents for Myocardial Ischemia Focusing on Myocardial Viscosity
- Principal Investigator
  
  宍戸稔聡
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  National Cardiovascular Center Research Institute
両心室機能評価装置を搭載した体外式搬送システムによる心停止ドナー心の選別
- Principal Investigator
  
  廣田真規
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Okayama University
Cause analysis of TAPVC generation using whole-genome analysis by next-generation sequencer
- Principal Investigator
  
  辻龍典
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Iwate Medical University
Development of a hemodynamic simulator of implantable ventricular assist devices for congenital heart diseasesPrincipal Investigator
- Principal Investigator
  
  清水秀二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  National Cardiovascular Center Research Institute
Investigation of gene expression in pulmonary atresia and intact ventricular septum
- Principal Investigator
  
  木佐森永理
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Okayama University
Mechanical support for right heart failure in single ventricle physiology
- Principal Investigator
  
  Kotani Yasuhiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Okayama University
Development of an ex-vivo heart perfusion system to monitor pre-transplant cardiac function for a DCD donor heart
- Principal Investigator
  
  hirota masanori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Showa University
  Okayama University
Development of a bed-side hemodynamic simulator for complex congenital heart anomalyPrincipal Investigator
- Principal Investigator
  
  Shimizu Shuji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  National Cardiovascular Center Research Institute
Effects of beta3 adrenergic receptor agonist on Myocardial Ischemia and Reperfusion
- Principal Investigator
  
  Kuroko Yosuke
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Okayama University
Development of a new method to estimate the ventricular viscosity using an integrated macro-micro model
- Principal Investigator
  
  SHISHIDO Toshiaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of a new pharmacotherapy for heart failure using alpha-2 adrenergic agonistsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Shuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Monoamine oxidae-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion
- Principal Investigator
  
  AKIYAMA Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Cardiovascular Center Research Institute
Central and peripheral effects of dexmedetomidine on autonomic cardiovascular regulation
- Principal Investigator
  
  KAWADA Toru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  National Cardiovascular Center Research Institute
myocardial interstitial serotonin and 5-hydroxyindole acetic acid levels during ischemia-reperfusion
- Principal Investigator
  
  AKIYAMA Tsuyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of optimized hemodynamic therapy guided by mean circulatory filling pressure or stressed blood volume.
- Principal Investigator
  
  SHISHIDO Toshiaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  National Cardiovascular Center Research Institute
Development of simulator for training of thoracic endovascular aneurysm repairPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Shuji
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  National Cardiovascular Center Research Institute
Development of a pharmacological autopilot system for hemodynamics of heart failure using adaptive control
- Principal Investigator
  
  SUGIMACHI Masaru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute
新しい原理に基づく低エネルギー除細動法の開発に関する基礎研究
- Principal Investigator
  
  稲垣正司
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute
Development of a computational Management system of hemodynamics in patients with acute myocardial infarction
- Principal Investigator
  
  UEMURA Kazunori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute

[Journal Article] Impact of delayed ventricular wall area ratio on pathophysiology of mechanical dyssynchrony: implication from single-ventricle physiology and 0D modeling2020
- Author(s)
  Hayama Yohsuke、Shimizu Shuji、Kawada Toru、Negishi Jun、Sakaguchi Heima、Miyazaki Aya、Ohuchi Hideo、Yamada Osamu、Kurosaki Kenichi、Sugimachi Masaru
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 70 Issue: 1 Pages: 38-38
- DOI
  10.1186/s12576-020-00765-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09282, KAKENHI-PROJECT-18K16408
[Journal Article] Ivabradine does not acutely affect open-loop baroreflex static characteristics and spares sympathetic heart rate control in rats2018
- Author(s)
  Yamamoto Hiromi、Kawada Toru、Shimizu Shuji、Uemura Kazunori、Inagaki Masashi、Kakehi Kazuyoshi、Iwanaga Yoshitaka、Fukuda Kanji、Miyamoto Tadayoshi、Miyazaki Shunichi、Sugimachi Masaru
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 257 Pages: 255-261
- DOI
  10.1016/j.ijcard.2017.11.115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-18K12126, KAKENHI-PROJECT-15H03101, KAKENHI-PROJECT-16K13023, KAKENHI-PROJECT-15K09113
[Journal Article] Tonic aortic depressor nerve stimulation does not impede baroreflex dynamic characteristics concomitantly mediated by the stimulated nerve2018
- Author(s)
  Kawada Toru、Turner Michael J.、Shimizu Shuji、Kamiya Atsunori、Shishido Toshiaki、Sugimachi Masaru
- Journal Title
  
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  
  Volume: 314 Issue: 3 Pages: R459-R467
- DOI
  10.1152/ajpregu.00328.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09110
[Journal Article] Wave reflection correlates with pulmonary vascular wall thickening in rats with pulmonary arterial hypertension.2017
- Author(s)
  Fukumitsu M, Kawada T, Shimizu S, Turner MJ, Uemura K, Sugimachi M.
- Journal Title
  
  Int J Cardiol.
  
  Volume: 249 Pages: 396-401
- DOI
  10.1016/j.ijcard.2017.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01307, KAKENHI-PROJECT-15K09110
[Journal Article] Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation2017
- Author(s)
  Kawada Toru、Shimizu Shuji、Yamamoto Hiromi、Miyamoto Tadayoshi、Shishido Toshiaki、Sugimachi Masaru
- Journal Title
  
  Life Sciences
  
  Volume: 190 Pages: 103-109
- DOI
  10.1016/j.lfs.2017.09.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K13023, KAKENHI-PROJECT-15H03101, KAKENHI-PROJECT-15K09110
[Journal Article] Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation.2017
- Author(s)
  Zhan DY, Du CK, Akiyama T, Morimoto S, Shimizu S, Kawada T, Shirai M, Pearson JT.
- Journal Title
  
  Auton Neurosci.
  
  Volume: 205 Pages: 33-40
- DOI
  10.1016/j.autneu.2017.03.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-17K11604, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-16K15452
[Journal Article] Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases2017
- Author(s)
  Shigemi K, Fuke S, Une D, Saku K, Shimizu S, Kawada T, Shishido T, Sunagawa K, Sugimachi M
- Journal Title
  
  J Physiol Sci
  
  Volume: 67 Issue: 6 Pages: 655-672
- DOI
  10.1007/s12576-017-0554-8
- NAID
  40021363293
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10954, KAKENHI-PROJECT-15K09110
[Journal Article] Desipramine increases cardiac parasympathetic activity via alpha2-adrenergic mechanism in rats.2017
- Author(s)
  Kawada T, Akiyama T, Shimizu S,Fukumitsu M, Kamiya A, Sugimachi M.
- Journal Title
  
  Auton Neurosci
  
  Volume: 99 Pages: 999-999
- DOI
  10.1016/j.autneu.2017.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01401, KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-17K11604
[Journal Article] Effects of different input pressure waveforms on the carotid sinus baroreflex-mediated sympathetic arterial pressure response in rats2017
- Author(s)
  Kawada Toru、Shimizu Shuji、Yamamoto Hiromi、Miyamoto Tadayoshi、Kamiya Atsunori、Shishido Toshiaki、Sugimachi Masaru
- Journal Title
  
  Journal of Applied Physiology
  
  Volume: 123 Issue: 4 Pages: 914-921
- DOI
  10.1152/japplphysiol.00354.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K13023, KAKENHI-PROJECT-15H03101, KAKENHI-PROJECT-15K09110
[Journal Article] Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation2016
- Author(s)
  Kawada T, Shimizu S, Turner MJ, Fukumitsu M, Yamamoto H, Sugimachi M
- Journal Title
  
  Life Sci.
  
  Volume: 149 Pages: 72-78
- DOI
  10.1016/j.lfs.2016.02.051
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-26750153
[Journal Article] Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits.2016
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Turner MJ, Fukumitsu M, Yamamoto H, Kamiya A, Shishido T, Sugimachi M.
- Journal Title
  
  J Physiol Sci.
  
  Volume: 31 Issue: 5 Pages: 165-173
- DOI
  10.1007/s12576-016-0489-5
- NAID
  40021302055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293389, KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-16K12889
[Journal Article] Aortic depressor nerve stimulation does not impede dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats.2016
- Author(s)
  Kawada T, Turner MJ, Shimizu S, Fukumitsu M3, Kamiya A, Sugimachi M.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 99 Issue: 5 Pages: 999-999
- DOI
  10.1152/ajpregu.00530.2016
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01401, KAKENHI-PROJECT-15K09110
[Journal Article] Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits.2015
- Author(s)
  Shimizu S, Kawada T, Akiyama T, Turner MJ, Shishido T, Kamiya A, Shirai M, Sugimachi M.
- Journal Title
  
  Autonomic Neuroscience
  
  Volume: 187 Pages: 84-87
- DOI
  10.1016/j.autneu.2014.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-26750153
[Journal Article] – Analysis of an Open-Loop Baroreflex Equilibrium Diagram –2015
- Author(s)
  Sata Y, Kawada T, Shimizu S, Kamiya A, Akiyama T, and Sugimachi M.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 3 Pages: 592-599
- DOI
  10.1253/circj.CJ-14-1013
- NAID
  130004927116
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J05473, KAKENHI-PROJECT-26462774
[Journal Article] Open-loop characteristics of the arterial baroreflex after blockade of unmyelinated baroreceptors with resiniferatoxin2015
- Author(s)
  Turner MJ, Kawada T, Shimizu S, Fukumitsu M, Sugimachi M
- Journal Title
  
  Auton Neurosci.
  
  Volume: 193 Pages: 38-43
- DOI
  10.1016/j.autneu.2015.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-26750153
[Journal Article] Differences in the dynamic baroreflex characteristics of unmyelinated and myelinated central pathways are less evident in spontaneously hypertensive rats2015
- Author(s)
  Turner MJ, Kawada T, Shimizu S, Fukumitsu M, Sugimachi M
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 309 Issue: 11 Pages: 1397-1405
- DOI
  10.1152/ajpregu.00315.2015
- NAID
  130005163756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-26750153
[Journal Article] Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet2015
- Author(s)
  Abe C, Nagai Y, Yamaguchi A, Aoki H, Shimizu S, Akiyama T, Kawada T, Sugimachi M, Morita H
- Journal Title
  
  American Journal of Physiology
  
  Volume: in press Issue: 8 Pages: H942-H950
- DOI
  10.1152/ajpheart.00697.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590298, KAKENHI-PROJECT-26462774
[Journal Article] Chronic vagal nerve stimulation improves baroreflex neural arc function in heart failure rats2014
- Author(s)
  Kawada T, Li M, Zheng C, Shimizu S, Uemura K, Turner MJ, Yamamoto H, Sugimachi M
- Journal Title
  
  J Appl Physiol (1985)
  
  Volume: 116(10) Issue: 10 Pages: 1308-1314
- DOI
  10.1152/japplphysiol.00140.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-24500565, KAKENHI-PROJECT-26461099
[Journal Article] Sustained reduction in blood pressure from electrical activation of the baroreflex is mediated via the central pathway of unmyelinated baroreceptors2014
- Author(s)
  Turner MJ, Kawada T, Shimizu S, Sugimachi M
- Journal Title
  
  Life Sciences
  
  Volume: 未定 Issue: 1-2 Pages: 40-49
- DOI
  10.1016/j.lfs.2014.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592319
[Journal Article] Acute Effects of Arterial Baroreflex on Sympathetic Nerve Activity and Plasma Norepinephrine Concentration2014
- Author(s)
  Kawada T, Akiyama T, Shimizu S, Sata Y, Turner MJ, Shirai M and Sugimachi M
- Journal Title
  
  Autonomic Neuroscience
  
  Volume: 186 Pages: 62-68
- DOI
  10.1016/j.autneu.2014.10.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J05473, KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-26750153
[Journal Article] Medetomidine Suppresses Cardiac and Gastric Sympathetic Nerve Activities but Selectively Activates Cardiac Vagus Nerve2014
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Kamiya A, Turner MJ, Yamamoto H, Shishido T, Shirai M, Sugimachi M
- Journal Title
  
  Circ J
  
  Volume: 78 Issue: 6 Pages: 1405-1413
- DOI
  10.1253/circj.CJ-13-1456
- NAID
  130003391129
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-26462774
[Journal Article] Effects of intravenous cariporide on release of norepinephrine and myoglobin releases during myocardial ischemia/reperfusion in rabbits.2014
- Author(s)
  Sakurai S, Kuroko Y, Shimizu S, Kawada T, Akiyama T, Yamazaki T, Sugimachi M, Sano S.
- Journal Title
  
  Life Science
  
  Volume: 114 Issue: 2 Pages: 102-106
- DOI
  10.1016/j.lfs.2014.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462774
[Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anaesthetized mice.2013
- Author(s)
  Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shirai M.
- Journal Title
  
  Auton Neurosci
  
  Volume: 176(1-2) Issue: 1-2 Pages: 91-94
- DOI
  10.1016/j.autneu.2013.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790791
[Journal Article] Sympathetic Afferent Stimulation Inhibits Central Vagal Activation Induced by Intravenous Medetomidine in Rats2013
- Author(s)
  Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Turner Michael J, Shirai M, Sugimachi M
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: 10 Issue: 1 Pages: 100-110
- DOI
  10.1111/apha.12123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390415, KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-24249086
[Journal Article] High-frequency dominant depression of peripheral vagal control of heart rate in rats with chronic heart failure2013
- Author(s)
  Kawada T, Li M, Shimizu S, Kamiya A, Uemura K, Turner MJ, Mizuno M, Sugimachi M
- Journal Title
  
  Acta Physiologica (Oxford)
  
  Volume: 207 Issue: 3 Pages: 494-502
- DOI
  10.1111/apha.12055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01705, KAKENHI-PROJECT-22590799, KAKENHI-PROJECT-23390415, KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-24500565
[Journal Article] Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats2013
- Author(s)
  Yamamoto H, Kawada T, Shimizu S, Kamiya A, Miyazaki S, Sugimachi M
- Journal Title
  
  Life Sci
  
  Volume: 92(24-26) Issue: 24-26 Pages: 1202-7
- DOI
  10.1016/j.lfs.2013.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390415, KAKENHI-PROJECT-23592319
[Journal Article] Central vagal activation by alpha2-adrenergic stimulation is impaired in spontaneously hypertensive rats2012
- Author(s)
  Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, et al
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: (in press) Issue: 1 Pages: 72-79
- DOI
  10.1111/j.1748-1716.2012.02439.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01705, KAKENHI-PROJECT-23390415, KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-23700550, KAKENHI-PROJECT-24500565
[Journal Article] Medetomidine, an .ALPHA.2-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control2012
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M.2., Shimizu S, Akiyaraa T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M
- Journal Title
  
  Circ J
  
  Volume: 76 Issue: 1 Pages: 152-159
- DOI
  10.1253/circj.CJ-11-0574
- NAID
  10030034497
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590920, KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23700550
[Journal Article] Centrally administered ghrelin activates cardiac vasal nerve in anesthetized rabbits2011
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M
- Journal Title
  
  Auton Neurosci
  
  Volume: 162 Issue: 1-2 Pages: 60-65
- DOI
  10.1016/j.autneu.2011.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-21591190, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213
[Journal Article] Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats2011
- Author(s)
  Kawada T, Shimizu S, Li M, Kamiya A, Uemura K, Sata Y, et al
- Journal Title
  
  Life Sci
  
  Volume: 13-14 Issue: 13-14 Pages: 498-503
- DOI
  10.1016/j.lfs.2011.07.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01705, KAKENHI-PROJECT-23592319
[Journal Article] Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation : a theoretical analysis2011
- Author(s)
  Shimizu S, Une D, Shishido T, Kamiya A, Kawada T, Sano S, Sugimachi M
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: Vol.61 Issue: 6 Pages: 457-465
- DOI
  10.1007/s12576-011-0166-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791328
[Journal Article] 胸部大動脈緊急症に対するステントグラフト療法2011
- Author(s)
  中井幹三,奥山倫弘,清水秀二,加藤源太郎,越智吉樹,岡田正比呂
- Journal Title
  
  胸部外科
  
  Volume: 64巻 Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791328
[Journal Article] 胸部大動脈緊急症に対するステントグラフト療法2011
- Author(s)
  中井幹三、奥山倫弘、清水秀二、加藤源太郎、越智吉樹、岡田正比呂
- Journal Title
  
  胸部外科
  
  Volume: 64 Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791328
[Journal Article] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change.2010
- Author(s)
  Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
- Journal Title
  
  Conf Proc IEEE Eng Med Biol Soc
  
  Volume: 1 Pages: 5205-5208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300164
[Journal Article] Successful Open Surgery for Recurrent Pseudo-aneurysm after Endovascular Aneurysm Repair in a Patient with Behcet's Disease2010
- Author(s)
  Nakai M, Shimizu S, Kato G, Mitsui H, Sano S
- Journal Title
  
  European Journal of Vascular and Endovascular Surgery Extra
  
  Volume: Vol.20 Issue: 1 Pages: 8-10
- DOI
  10.1016/j.ejvsextra.2010.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791328
[Journal Article] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change.2010
- Author(s)
  Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
- Journal Title
  
  Conf Proc IEEE Eng Med Biol Soc.(peer-reviewed) Vol.1
  
  Pages: 5205-5208
- Data Source
  KAKENHI-PROJECT-20300164
[Journal Article] Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis.2010
- Author(s)
  Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M.
- Journal Title
  
  J Physiol Sci
  
  Volume: 60(3) Issue: 3 Pages: 205-12
- DOI
  10.1007/s12576-010-0086-y
- NAID
  10027711824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591758, KAKENHI-PROJECT-22791328
[Journal Article] Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle : a theoretical analysis2010
- Author(s)
  Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M
- Journal Title
  
  J Physiol Sci
  
  Volume: 60 Pages: 205-212
- NAID
  10027711824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591758
[Journal Article] Right ventricular stiffness constant as a predictor of postoperative hemo dynamics in patients with hypoplastic right ventricle : a theoretical analysis.2010
- Author(s)
  Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M.
- Journal Title
  
  J Physiol Sci
  
  Volume: 60 Pages: 205-212
- NAID
  10027711824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300164
[Journal Article] Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle : a theoretical analysis2010
- Author(s)
  Shimizu S, Shishido T, Une D.
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 60 Pages: 205-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791328
[Journal Article] Right ventricular stiffness constant as a predictor of postoperative hemody- namics in patients with hypoplasticright ventricle : a theoretical analysis.2010
- Author(s)
  Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M.
- Journal Title
  
  J Physiol Sci.(peer-reviewed) Vol.60
  
  Pages: 205-212
- Data Source
  KAKENHI-PROJECT-20300164
[Journal Article] Feedback control of multiple hemodynamic variables with multiplecardiovascular drugs.2009
- Author(s)
  Sugimachi M, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
- Journal Title
  
  Conf Proc IEEE Eng Med Biol Soc.(peer-reviewed) Vol.1
  
  Pages: 2030-2032
- Data Source
  KAKENHI-PROJECT-20300164
[Journal Article] Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model : high-resolution optical mapping study.2006
- Author(s)
  Aiba T, Shimizu W, Hidaka I, Uemura K, Noda T, Zheng C, Kamiya A, Inagaki M, Sugimachi M, Sunagawa K.
- Journal Title
  
  J Am Coll Cardiol. Reviwed 47
  
  Pages: 2074-2085
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500358
[Journal Article] Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure.2006
- Author(s)
  Uemura K, Kamiya A, Hidaka I, Kawada T, Shimizu S, Shishido T, Yoshizawa M, Sugimachi M, Sunagawa K.
- Journal Title
  
  J Appl Physiol. Reviwed 100
  
  Pages: 1278-1286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500358
[Journal Article] Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model : high-resolution optical mapping study2006
- Author(s)
  Aiba T, Shimizu W, Hidaka I, Uemura K, Noda T, Zheng C, Kamiya A, Inagaki M, Sugimachi M, Sunagawa K
- Journal Title
  
  J AM Coll Cardiol 47
  
  Pages: 2074-2085
- Data Source
  KAKENHI-PROJECT-18650129
[Presentation] Understanding of Fontan Circulation: The introduction of Hemodynamic Simulation2024
- Author(s)
  Shuji Shimizu, Yasuhiro Kotani, Koji Uemura, Shingo Kasahara, Toshiaki Shishido
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22K12794
[Presentation] コンピュータ・シミュレーションを用いたフォンタン循環における植え込み型補助人工心臓の効果の検証2023
- Author(s)
  清水秀二、木佐森永理、小谷恭弘、笠原真悟、宍戸稔聡
- Organizer
  第62回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-22K12794
[Presentation] Fenestration improves the hemodynamics in the failing Fontan patients under mechanical circulatory support2023
- Author(s)
  Shuji Shimizu, Yasuhiro Kotani, Toshiaki Shishido
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-22K12794
[Presentation] Fenestration improves the hemodynamics in the failing Fontan patients under mechanical circulatory support2023
- Author(s)
  Shuji Shimizu, Yasuhiro Kotani, Toshiaki Shishido
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-19K09282
[Presentation] フォンタン循環を理解する2023
- Author(s)
  清水秀二
- Organizer
  第101回日本生理学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09266
[Presentation] フォンタン不全における左心補助循環とフェネストレーションの有効性の検討2023
- Author(s)
  清水秀二、小谷恭弘、笠原真悟、宍戸稔聡
- Organizer
  第44回日本循環制御医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09266
[Presentation] フォンタン不全における左心補助循環とフェネストレーションの有効性の検討2023
- Author(s)
  清水秀二、小谷恭弘、笠原真悟、宍戸稔聡
- Organizer
  第44回日本循環制御医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K12794
[Presentation] Effects of ventricular assist device with a fenestration in the failing Fontan circulation: a theoretical analysis using a lumped parameter model2023
- Author(s)
  Shuji Shimizu, Yasuhiro Kotani, Naohiro Horio, Eiri Kisamori, Koji Uemura, Shingo Kasahara, Toshiaki Shishido
- Organizer
  ESC Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12794
[Presentation] 左室心筋粘性の存在は不全心の左室心筋弾性を見かけ上、低下させる2022
- Author(s)
  清水秀二、小谷恭弘、宍戸稔聡
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K09282
[Presentation] Effects of the left ventricular viscosity on a failed heart: An in-silico an alysis2020
- Author(s)
  Shimizu Shuji、Kotani Yasuhiro、Shishido Toshiaki
- Organizer
  第59回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-19K09282
[Presentation] α2C-adrenoceptors play a key role in α2-adrenergic agonist-induced cardiac autonomic nervous responses2018
- Author(s)
  清水秀二、秋山　剛、川田　徹、羽山陽介、宍戸稔聡、杉町　勝
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Detection of vagal component in baroreflex-mediated dynamic heart rate response in anesthetized rats2018
- Author(s)
  川田　徹、清水秀二、羽山陽介、宍戸稔聡、杉町　勝
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Cardiac-specific microRNAs significantly increase after myocardial reperfusion in the ischemic region2018
- Author(s)
  清水秀二、山崎　悟、川田　徹、秋山　剛、羽山陽介、宍戸稔聡、杉町　勝
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Statin enhances cardiac parasympathetic component of heart rate variability in patients with abdominal aortic aneurysm2018
- Author(s)
  中西浩之、福家聡一郎、溝渕朝子、津島　龍、田中正道、湯本晃久、齋藤博則、清水秀二、川田　徹、佐藤哲也
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Cardiac microdialysis enables us to monitor myocardial interstitial microRNA levels in an in-vivo beating rat heart during ischemia/reperfusion2017
- Author(s)
  Shuji Shimizu, Satoru Yamazaki, Tsuyoshi Akiyama, Toru Kawada, James T Pearson, Toshiaki Shishido, Masaru Sugimachi
- Organizer
  ESC Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] 腎内因性アセチルコリンへの介入は、食塩感受性高血圧ラットの腎組織障害を低減する2017
- Author(s)
  清水秀二、川田　徹、福満雅史、秋山　剛、宍戸稔聡、杉町　勝
- Organizer
  第38回日本循環制御医学会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Central α2-Adrenergic Receptors, but notα2A-Receptor, Play a Key Role in Aortic Depressor Nerve Stimulation-induced Cardiac Parasympathetic Activation2017
- Author(s)
  清水秀二、川田　徹、秋山　剛、福満雅史、宍戸稔聡、杉町　勝
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] 再灌流は、虚血心筋での血管内皮細胞特異的microRNA分泌を促す2017
- Author(s)
  清水秀二、山崎　悟、川田　徹、秋山　剛、羽山陽介、James T Pearson、宍戸稔聡、杉町　勝
- Organizer
  第110回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Central α2-Adrenergic Receptors, but notα2A-Receptor, Play a Key Role in Aortic Depressor Nerve Stimulation-induced Cardiac Parasympathetic Activation2017
- Author(s)
  清水秀二、川田　徹、秋山　剛、福満雅史、宍戸稔聡、杉町　勝
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢市
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26462774
[Presentation] The α2-adrenergic pathway enhances aortic depressor nerve stimulation-induced parasympathetic acetylcholine release to the heart2016
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Fukumitsu M, Turner MJ, Shishido T, Sugimachi M
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Medetomidine but not guanfacine enhances cardiac parasympathetic acetylcholine release during aortic depressor nerve stimulation2016
- Author(s)
  Shimizu S, Kawada T, Akiyama T, Fukumitsu M, Kamiya A, Shishido T, Sugimachi M
- Organizer
  ESC Congress 2016
- Place of Presentation
  Roma, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] 腹部大動脈瘤の増大は日中の心臓副交感神経活動を減弱させる2016
- Author(s)
  清水秀二、福家聡一郎、中西浩之、津島　龍、柏原悠也、守谷知香、田中正道、湯本晃久、齋藤博則、川田　徹、杉町　勝、佐藤哲也
- Organizer
  第37回日本循環制御医学会総会
- Place of Presentation
  東京
- Year and Date
  2016-07-08
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Cardiac vagal control in knock-in mouse model of dilated cardiomyopathy.2016
- Author(s)
  Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T Pearson.
- Organizer
  AHA Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462774
[Presentation] Medetomidine but not guanfacine enhances cardiac parasympathetic acetylcholine release during aortic depressor nerve stimulation.2016
- Author(s)
  Shimizu S, Kawada T, Akiyama T, Fukumitsu M, Kamiya A, Shishido T, Sugimachi M.
- Organizer
  ESC Congress 2016
- Place of Presentation
  Roma, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462774
[Presentation] メデトミジンは大動脈減圧神経刺激による心臓アセチルコリン分泌を増強する2015
- Author(s)
  清水秀二、川田　徹、秋山　剛、マイケル　ターナー、福満雅史、神谷厚範、宍戸稔聡、杉町　勝
- Organizer
  第36回日本循環制御医学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] 大動脈減圧神経刺激による心臓迷走神経活動の亢進は、α2アドレナリン受容体刺激により修飾される2015
- Author(s)
  清水秀二、川田　徹、マイケル　ターナー、秋山　剛、杉町　勝
- Organizer
  第108回近畿生理学談話会
- Place of Presentation
  大阪
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-15K09110
[Presentation] Baroreflex activation therapy in Wistar Kyoto and spontaneously hypertensive rats – responders and non-responders?2014
- Author(s)
  Turner M, Kawada T, Shimizu S, Sugimachi M
- Organizer
  The 78th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] 心不全および高血圧における動脈圧受容器反射の開ループ特性2014
- Author(s)
  川田徹,清水秀二,ターナーマイケルジェームズ,杉町勝
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] 「DCMノックインマウスにおける心臓迷走神経調節機構」Cardiac vagal control in a knock-in mouse of dilated cardiomyopathy with a troponin mutation2014
- Author(s)
  戦冬雲、杜成坤、秋山剛、森本幸生、清水秀二、川田徹、白井幹康
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] ノックインマウスにおける心臓迷走神経調節機構2014
- Author(s)
  戦冬雲, 杜成坤, 秋山剛, 森本幸生, 清水秀二, 川田徹, 白井幹康
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Sodium-dependent non-neuronal acetylcholine release in the kidney2014
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Turner MJ, Shishido T, Shirai M, Sugimachi M
- Organizer
  The 78th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] DCMノックインマウスにおける心臓迷走神経調節機構2014
- Author(s)
  戦　冬雲、杜　成坤、秋山　剛、森本　幸生、清水　秀二、川田　徹、白井　幹康
- Organizer
  第９１回日本生理学会大会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] Medetomidine can selectively activate cardiac vagal nerve without vagal activation in gastrointestinal tract2013
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Shishido T, Kamiya A, Sugimachi M
- Organizer
  ESC Congress 2013
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Medetomidine can selectively activate cardiac vagal nerve without vagal activation in gastrointestinal tract2013
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Shishido T, Kamiya A, Sugimachi M
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] An alpha2-adrenergic agonist, medetomidine, enhances cardiac vagal acetylcholine release without gastric vagal over-activation seen in electrical stimulation2013
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Kamiya A, Shishido T, Sugimachi M
- Organizer
  The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Effects of chronic vagal stimulation on open-loop baroreflex function in heart failure rats2013
- Author(s)
  Kawada T, Li M, Zheng C, Shimizu S, Kamiya A, Turner MJ, Sugimachi M
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Loss of high-frequency dynamic heart rate response to vagal stimulation in chronic heart failure rats2013
- Author(s)
  Kawada T, Li M, Shimizu S, Sata Y, Kamiya A, Uemura K, Yamamoto H, Sugimachi M
- Organizer
  The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] マイクロダイアリシス法による腎内因性アセチルコリン分泌機構の解明2013
- Author(s)
  清水秀二, 川田徹, マイケル・ジェームズ・ターナー, 神谷厚範, 秋山剛, 白井幹康, 杉町勝
- Organizer
  第106回近畿生理学談話会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] 「α_2Aアドレナリン受容体作動薬であるグアンファシンは、過度の交感神経抑制なしに心臓迷走神経活動を亢進する」α2A adrenergic agonist, Guanfacine, can activate cardic vagal nerve without sympathetic over-suppression2013
- Author(s)
  清水秀二、川田徹、秋山剛、神谷厚範、白井幹康、杉町勝
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] Effects of chronic vagal stimulation on open-loop baroreflex function in heart failure rats2013
- Author(s)
  Kawada T, Li M, Zheng C, Shimizu S, Kamiya A, Turner MJ, Sugimachi M
- Organizer
  AHA Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] alpha2A adrenergic agonist, Guanfacine, can activate cardic vagal nerve without sympathetic over-suppression2013
- Author(s)
  清水　秀二、川田　徹、秋山　剛、神谷　厚範、白井　幹康、杉町　勝
- Organizer
  第９０回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] Loss of high-frequency dynamic heart rate response to vagal stimulation in chronic heart failure rats2013
- Author(s)
  Kawada T, Li M, Shimizu S, Sata Y, Kamiya A, Uemura K, Yamamoto H, Sugimachi M
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Soceity
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Accentuated antagonism is different from increasing vagal stimulation intensity in its effect on dynamic heart rate control in rats2013
- Author(s)
  Kawada T, Shimizu S, Sata Y, Li M, Kamiya A, Uemura K, Yamamoto H, Sugimachi M
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Soceity
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Effects of L-type Ca2+ channel blocker nifedipine on dynamic arterial blood pressure control2013
- Author(s)
  Kawada T, Yamamoto H, Shimizu S, Turner MJ, Sugimachi M
- Organizer
  IEEE EMBC 2013
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] An alpha-2 adrenergic agonist, medetomidine, enhances cardiac vagal acetylcholine release without gastric vagal over-activation seen in electrical stimulation2013
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Kamiya A, Shishido T, Sugimachi M
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Soceity
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] 迷走神経刺激治療は心不全ラットの動脈圧受容器反射の中枢機能を改善する2013
- Author(s)
  川田徹,李梅花,鄭燦,清水秀二,ターナーマイケル,神谷厚範,上村和紀,杉町勝
- Organizer
  第34回日本循環制御医学会総会
- Place of Presentation
  Fukui
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] 迷走神経刺激治療は心不全ラットの動脈圧受容器反射の中枢機能を改善する2013
- Author(s)
  川田徹, 李梅花, 鄭燦, 清水秀二, ターナーマイケル, 神谷厚範, 上村和紀, 杉町勝
- Organizer
  第34回日本循環制御医学会総会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Differential unmyelinated baroreceptor central pathway of the arterial baroreflex between spontaneously hypertensive and normotensive rats2013
- Author(s)
  Turner MJ, Shimizu S, Kawada T, Sugimachi M
- Organizer
  第106回近畿生理学談話会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Stimulation frequency dependence of dynamic vagal control of heart rate in rats2013
- Author(s)
  Kawada T, Shimizu S, Kamiya A, Li M, Turner MJ, Sugimachi M
- Organizer
  The 90th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  船堀
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Hemodynamic simulation of bilateral pulmonary artery banding for hypoplastic left heart syndrome2012
- Author(s)
  Shimizu S, Kawada T, Kamiya A, Sugimachi M
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市総合体育館(松本)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Oxidative stress plays a significant role in baroreflex neural arc in both normotensive and spontaneously hypertensive rats2012
- Author(s)
  Kawada T, Shimizu S, Sata Y, Li M, Kamiya A, Uemura K, Sugimachi M
- Organizer
  The 76th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] A better transfer function model for vagally mediated dynamic heart rate control in rats2012
- Author(s)
  Kawada T, Zheng C, Uemura K, Turner MJ, Shimizu S, Kamiya A, Sugimachi M
- Organizer
  The 51st Annual Conference of Japanese Society of Medical and Biological Engineering
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] メデトミジンは心臓迷走神経活動を賦活化し、胃迷走神経活動を抑制する2012
- Author(s)
  清水秀二,川田徹,秋山剛,神谷厚範,杉町勝
- Organizer
  第105回近畿生理学談話会
- Place of Presentation
  大阪
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] ラットにおける迷走神経による動的心拍数調節の新しいモデル化2012
- Author(s)
  川田徹, 李梅花, 鄭燦, 清水秀二, 上村和紀, 神谷厚範, 杉町勝
- Organizer
  第33回日本循環制御医学会総会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Hemodynamic simulation of bilateral pulmonary artery banding for hypoplastic left heart syndrome2012
- Author(s)
  清水秀二,川田徹,神谷厚範,杉町勝
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市総合体育館,松本
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Consideration on parameter determination of a new model describing dynamic vagal heart rate control in rats2012
- Author(s)
  Kawada T, Uemura K, Shimizu S, Kamiya A, Turner M, Mizuno M, Sunagawa K, Sugimachi M
- Organizer
  IEEE EMBC 2012
- Place of Presentation
  米国サンディエゴ
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Alpha2 adrenergic agonists enhances baroreflex-induced cardiac vagal acetylcholine release2011
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Kamiya A, Shirai M, Sugimachi M
- Organizer
  The 75^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Cavopulmonary shunt after LVAD implantation improves haemodynamics in patients having relatively impared right heart : an in-silico analysis2011
- Author(s)
  Shimizu S, Shishido T, Kawada T, Sata Y, Kamiya A, Sugimachi M
- Organizer
  ESC congress 2011
- Place of Presentation
  Paris Nord Villepinte, France
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] 胸部大動脈瘤ステントグラフト内挿術のドライラボ・シミュレータの開発2011
- Author(s)
  清水秀二
- Organizer
  第41回日本心臓血管外科学会総会
- Place of Presentation
  東京ベイ舞浜ホテルクラブリゾート(千葉)
- Year and Date
  2011-02-23
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Alpha2-adrenergic stimulation-induced vagal activation is impaired in spontaneously hypertensive rats2011
- Author(s)
  Kawada T, Akiyama T, Shimizu S, Li M, Sata Y, Kamiya A, Shirai M, Sugimachi M
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  米国オーランド
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Alpha2 adrenergic agonists enhances baroreflex-induced cardiac vagal acetylcholine release2011
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sata Y, Kamiya A, Shirai M, Sugimachi M
- Organizer
  The 75th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Alpha2-adrenergic stimulation-induced vagal activation is impaired in spontaneously hypertensive rats2011
- Author(s)
  Kawada T, Akiyama T, Shimizu S, Li M, Sata Y, Kamiya A, Shirai M, Sugimachi M
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] Consideration on step duration to assess open-loop static characteristics of the carotid sinus baroreflex in rats2011
- Author(s)
  Kawada T, Sata Y, Shimizu S, Kamiya A, Sunagawa K, Sugimachi M
- Organizer
  33rd Annual International Conference of the IEEE Engineering in Medical and Biology Society
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-23592319
[Presentation] 胸部大動脈瘤ステントグラフト内挿術のドライラボ・シミュレータの開発2011
- Author(s)
  清水秀二,中井幹三,杉町勝
- Organizer
  第41回日本心臓血管外科学会総会
- Place of Presentation
  東京ベイ舞浜ホテルクラブリゾート,千葉
- Year and Date
  2011-02-23
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Cavopulmonary shunt after LVAD implantation improves haemodynamics in patients having relatively impared right heart : an in-silico analysis2011
- Author(s)
  Shimizu S, Shishido T, Kawada T, Sata Y, Kamiya A, Sugimachi M
- Organizer
  ESC congress 2011
- Place of Presentation
  Paris Nord Villepinte(フランス)
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Development of training device for endovascular aneurysm repair under pulsatile hydrodynamics2010
- Author(s)
  清水秀二,中井幹三,丸山良浩,町野圭司,川田徹,神谷厚範,宍戸稔聡,杉町勝
- Organizer
  第49回日本生体医工学会大会
- Place of Presentation
  大阪国際交流センター,大阪
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change2010
- Author(s)
  Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T
- Organizer
  IEEE Engineering in Medicine and Biology Society
- Place of Presentation
  Buenos Aires, Argentine
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22591758
[Presentation] Development of training device for endovascular aneurysm repair under pulsatile hydrodynamics2010
- Author(s)
  清水秀二
- Organizer
  第49回日本生体医工学会大会
- Place of Presentation
  大阪国際交流センター(大阪)
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change.2010
- Author(s)
  Sugimachi M, Sunagawa K, Uenmura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
- Organizer
  IEEE Engineering in Medicine and Biology Society.
- Place of Presentation
  Buenos Aires, Argentine.
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22591758
[Presentation] Effects of α_2-adrenergic agonist on cardiac sympathetic and parasympathetic nerve activities2010
- Author(s)
  清水秀二
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホールいわて県民情報交流センター(岩手)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Myocardial entropy : a new concept of mechano-energetico-informatics2010
- Author(s)
  Shimizu S, Suga H, Sugimachi M
- Organizer
  19^<th> International Conference of the Cardiovascular System Dynamics Society
- Place of Presentation
  Centennial Hall Kyushu University School of Medicine, Fukuoka
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Myocardial entropy: a new concept of mechano-energetico-informatics2010
- Author(s)
  清水秀二
- Organizer
  19^<th> International Conference of the Cardiovascular System Dynamics Society
- Place of Presentation
  Centennial Hall Kyushu University School of Medicine(福岡)
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Effects ofα_2-adrenergic agonist on cardiac sympathetic and para-sympathetic nerve activities2010
- Author(s)
  清水秀二,秋山剛,川田徹,神谷厚範,宍戸稔聡,白井幹康,杉町勝
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホール・いわて県民情報交流センター,岩手
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22791328
[Presentation] Autopilot system enables simultaneous hemodynamic normalization and cardiac protection.2010
- Author(s)
  Sugimachi M, Uemura K, Shishido T, Shimizu S, Sunagawa K.
- Organizer
  Cardiovascular System Dynamic Society.
- Place of Presentation
  福岡
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22591758
[Presentation] Autopilot system enables simultaneous hemodynamic normalization and cardiac protection.2010
- Author(s)
  Sugimachi M, Uemura K, Shishido T, Shimizu S, Sunagawa K
- Organizer
  Cardiovascular System Dynamics Society
- Place of Presentation
  福岡
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22591758
[Presentation] Macroscopic two-pumptwo-vasculature cardiovascular model to support treatment of acute heart failure.2009
- Author(s)
  Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
- Organizer
  IEEE Engineering in Medicine and Biology Society.
- Place of Presentation
  Minneapolis, Minnesota, USA
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20300164
[Presentation] Theoretical and experimental demonstration of minimizing O_2 consumption under preserved hemodynamics in heart failure.2008
- Author(s)
  Sugimachi M, Uemura K, Shishido T, Kamiya A, Shimizu S, Sunagawa K.
- Organizer
  18th Cardiovascular System Dynamics Society.
- Place of Presentation
  Saint Louis, Missouri, USA
- Year and Date
  2008-09-28
- Data Source
  KAKENHI-PROJECT-20300164
[Presentation] Automated drug infusion system can improve cardiac energetic efficiency while restoring normal hemodynamic condition in acute heart failure.2006
- Author(s)
  Uemura K, Kamiya A, Shimizu S, Sugimachi M, Sunagawa K.
- Organizer
  17th Cardiovascular System Dynamics Society
- Place of Presentation
  Vaals, Netherlands
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500358
[Presentation] 心房マイクロダイアリシス法による心臓自律神経活動の定量化と心不全治療のための心臓保護薬の検索
- Author(s)
  清水秀二、川田　徹、秋山　剛、神谷厚範、宍戸稔聡、白井幹康、杉町　勝
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26462774

1. Kotani Yasuhiro (90534678)

# of Collaborated Projects: 11 results

# of Collaborated Products: 9 results
2. 笠原真悟 (90233692)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
3. SHISHIDO Toshiaki (60300977)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
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# of Collaborated Products: 53 results
6. AKIYAMA Tsuyoshi (70202554)

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# of Collaborated Products: 20 results
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8. SUGIMACHI Masaru (40250261)

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16. LI Meihua (60443496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
17. SONOBE Takashi (70548289)

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18. UEMURA Kazunori (10344350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. KAMIYA Atsunori (30324370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
20. INAGAKI Tadakatsu (20638366)

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23. 木佐森永理 (60894954)

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24. 枝木大治 (90969205)

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25. 加藤源太郎 (10365744)

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26. 鈴木浩之 (80969204)

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# of Collaborated Products: 0 results
27. 辻龍典 (10839004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. FUKUMITSU Masafumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
29. TO Seikon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. Zhan Dong-Yun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. MORITA Hironobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 宮本忠吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 重見研司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. TURNER M.J.

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 安部力

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU SHUJI 清水 秀二

Shimizu Shuji 清水 秀二

SHIMIZU Shuji 清水 秀二

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Development of a hemodynamic simulator of implantable ventricular assist devices for congenital heart diseasesPrincipal Investigator

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Development of a bed-side hemodynamic simulator for complex congenital heart anomalyPrincipal Investigator

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Development of a new pharmacotherapy for heart failure using alpha-2 adrenergic agonistsPrincipal Investigator

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SHIMIZU SHUJI 清水秀二

Shimizu Shuji 清水秀二

SHIMIZU Shuji 清水秀二