Motegi Akira 茂木章

… Alternative Names

MOTEGI Akira 茂木章

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Researcher Number	80452332
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2016 – 2021: 京都大学, 医学研究科, 助教 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 大学院・医学研究科, 助教 2007 – 2011: Kyoto University, 医学研究科, 助教 2010: 京都大学, 大学院・医学研究科, 助教 2008: Kyoto University, 大学院・医学研究科, 助教
Review Section/Research Field	Principal Investigator Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals Except Principal Investigator Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 複製後修復 / ユビキチン / 相同組換え / DNA損傷トレランス / DNA修復 / 組換え修復 / Rad5 / 組替え修復 / 組み替え修復 / ユビキチン化 … More Except Principal Investigator … More ハイスループットスクリーニング / 有害化学物質 / 化審法 / 変異 / DNA修復 / 標的組み換え / DNA組み換え / ニワトリBリンパ細胞 / DT40 / 遺伝子治療 / 標的組換え / DNA組換え Less

English titlePrincipal Investigator
- Principal Investigator
  
  Motegi Akira
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Analysis of DNA-damage-tolerance mechanisms that facilitate restart of stalled DNA replicationPrincipal Investigator
- Principal Investigator
  
  MOTEGI AKIRA
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Analysis of regulatory mechanisms of DNA repair by ubiquitinationPrincipal Investigator
- Principal Investigator
  
  MOTEGI Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
Analysis of DNA damage response using gene-disrupted DT40 clones.
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
Ubiquitin-dependent regulation of DNA replication arrestPrincipal Investigator
- Principal Investigator
  
  MOTEGI Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University

All 2020 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] HDAC3 is required for XPC recruitment and nucleotide excision repair of DNA damage induced by UV irradiation2020
- Author(s)
  1.Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda, and Masatoshi Kitagawa
- Journal Title
  
  Mol. Cancer Res.
  
  Volume: 18 Issue: 9 Pages: 1367-1378
- DOI
  10.1158/1541-7786.mcr-20-0214
- NAID
  120007165672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00548, KAKENHI-PROJECT-20K07308, KAKENHI-PROJECT-18H02818
[Journal Article] Aberrations in DNA repair pathways in cancer and therapeutic significances2019
- Author(s)
  Akira Motegi, Mitsuko Masutani, Ken-ichi Yoshioka, and Tadashi Bessho
- Journal Title
  
  Seminars in Cancer Biology
  
  Volume: 58 Pages: 29-46
- DOI
  10.1016/j.semcancer.2019.02.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00548
[Journal Article] PARI regulates stalled replication fork proessing to maintain genome stability upon replication stress in mice2017
- Author(s)
  Ayako L. Mochizuki, Ami Katanaya, Eri Hayashi, Mihoko Hosokawa, Emiko Moribe, Akira Motegi, Masamichi Ishiai,Minoru Takata, Gen Kondoh, Hitomi Watanabe, Norio Nakatsuji, and Shinichiro Chuma
- Journal Title
  
  Mol. Cell. Biol
  
  Volume: 37 (23) Issue: 23
- DOI
  10.1128/mcb.00117-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00548, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112004, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-15K21098
[Journal Article] Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair2017
- Author(s)
  Niida, H., Matsunuma, R., Horiguchi, R., Uchida, C., Nakazawa, Y., Motegi, A., Nishimoto, K., Sakai, S., Ohhata, T., Kitagawa, K., Moriwaki, S., Nishitani, H., Ui, A., Ogi, T. and Kitagawa, M.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 16102-16102
- DOI
  10.1038/ncomms16102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06994, KAKENHI-PROJECT-16K08580, KAKENHI-PROJECT-17K00548, KAKENHI-PROJECT-17K19615
[Journal Article] Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.2016
- Author(s)
  Wang J, Ding Q, Fujimori H, Motegi A, Miki Y, Masutani M.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Issue: 7 Pages: 7701-7714
- DOI
  10.18632/oncotarget.6715
- NAID
  120005820856
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04693, KAKENHI-PROJECT-25340030, KAKENHI-PROJECT-15K14394
[Journal Article] Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end-joining2015
- Author(s)
  Shunsuke Kobayashi, Yohei Kasaishi, Shinichiro Nakada, Tokiyo Takagi, Saho Era, Akira Motegi, Roland K. Chiu, Shunichi Takeda, and Kouji Hirota
- Journal Title
  
  Oncogene
  
  Volume: 34 Issue: 33 Pages: 4403-4411
- DOI
  10.1038/onc.2014.371
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340030
[Journal Article] Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end-joining2015
- Author(s)
  Michael Schmid, Akira Motegi (ほか総計106名、代表者は前から63番目)
- Journal Title
  
  Cytogenet. Genome Res.
  
  Volume: 145 Issue: 2 Pages: 78-179
- DOI
  10.1159/000430927
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340030, KAKENHI-PLANNED-23114010, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-26550026
[Journal Article] Multiple genetic manipulations of DT40 cell line2014
- Author(s)
  Akira Motegi, Minoru Takata
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1114 Pages: 25-35
- DOI
  10.1007/978-1-62703-761-7_3
- ISBN
  9781627037600, 9781627037617
- Data Source
  KAKENHI-PROJECT-25340030
[Journal Article] Multiple genetic manipulations of DT40 cell line2013
- Author(s)
  Akira Motegi
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 未定
- Data Source
  KAKENHI-PROJECT-22510059
[Journal Article] The SUMO protease SENP1is required for cohesion maintenanceand mitotic arrest following spindlepoison treatment2012
- Author(s)
  Era S, Abe T, Arakawa H, Kobayashi S,Szakal B, Yoshikawa Y, Motegi A, TakedaS, Branzei D
- Journal Title
  
  Biochem Biophys ResCommun
  
  Volume: 426 Pages: 310-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510059
[Journal Article] Dpb11/TopBP1 plays distinct roles inDNA replication2011
- Author(s)
  Germann SM, Oestergaard VH, Haas C,Salis P, Motegi A, Lisby M.
- Journal Title
  
  checkpoint responseand homologous recombination
  
  Volume: 10 Pages: 210-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510059
[Journal Article] Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination2011
- Author(s)
  Germann SM, Oestergaard VH, Haas C, Salis P, Motegi A, Lisby M
- Journal Title
  
  DNA Repair
  
  Volume: 10 Pages: 201-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510059
[Journal Article] Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions2010
- Author(s)
  Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE, Lehmann A, Takeda S
- Journal Title
  
  PLoS Genetics
  
  Volume: 6(10)
- NAID
  120002661519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510059
[Journal Article] Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.2010
- Author(s)
  Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE, Lehmann A, Takeda S.
- Journal Title
  
  PLoS Genet.
  
  Volume: 6
- NAID
  120002661519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Simultaneous disruption of two DNApolymerases, Polη and Polζ, in avianDT40 cells unmasks the role of Polη incellular response to various DNAlesions2010
- Author(s)
  Hirota K, Sonoda E, Kawamoto T, MotegiA, Masutani C, Hanaoka F, Szuts D, IwaiS, Sale JE, Lehmann A, Takeda S
- Journal Title
  
  PLoS Genet
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510059
[Journal Article] Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.2010
- Author(s)
  Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE, Lehmann A, Takeda S.
- Journal Title
  
  PLoS Genet. 6
- NAID
  120002661519
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] The Vital Link between the Ubiquitin-Proteasome Pathway and DNA Repair : Impact on Cancer Therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] 抗がん剤で考えるDNA組み換えの制御機構2009
- Author(s)
  茂木章, 武田俊一
- Journal Title
  
  タンパク質・核酸・酵素別冊 54
  
  Pages: 450-458
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] The vital link between the ubiquitin-proteasome pathway and DNA repair : Impact on cancer therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett. VOL.283
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] 抗がん剤で考えるDNA組み換えの制御機構2009
- Author(s)
  茂木章, 武田俊一
- Journal Title
  
  タンパク質・核酸・酵素別冊 54(4)
  
  Pages: 450-458
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] Roles of proteasome in DNA repair : impacts of proteasome inhibiotors on cancer therapy2009
- Author(s)
  Akira Motegi, Yasuhiro Murakawa, Shunichi Takeda
- Journal Title
  
  Cancer Letters
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] The vital link between the ubiquitin-proteasome pathway and DNA repair : Impact on cancer therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett.(Review) 283
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks2008
- Author(s)
  Akira Motegi, Hung-jiun Liaw. Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu. Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, Kyungjae Myung
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 12411-12416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks2008
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, and Kyungjae Myung
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 12411-12416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] Mph1 promotes gross chromosomal rearrangement through partial inhibition of homologous recombination J2008
- Author(s)
  Soma Banerjee, Stephanie Smith, Ji-Hyun Oum, Hung-Jiun Liaw, Ji-Young Hwang, Nilabja Sikdar, Akira Motegi, Sang Eun Lee, and Kyungjae Myung
- Journal Title
  
  Cell Biol 181
  
  Pages: 1083-1093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] ユビキチン化によるDNA修復の制御機構2008
- Author(s)
  茂木章, 村川泰裕, 武田俊一
- Journal Title
  
  実験医学別冊 26(2)
  
  Pages: 62-70
- NAID
  40015691605
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] Mphl promotes gross chromosomal rearrangement through partial inhibition of homologous recombination2008
- Author(s)
  Soma Banerjee, Stephanie Smith, Ji-Hyun Oum, Hung-Jiun Liaw, Ji-Young Hwang, Nilabja Sikdar, Akira Motegi, Sang Eun Lee, Kyungjae Myung
- Journal Title
  
  J. Cell Biol. 181
  
  Pages: 1083-1093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] ユビキチン化によるDNA修復の制御機構2008
- Author(s)
  茂木章、村川泰裕、武田俊一
- Journal Title
  
  羊土社 26(2)
  
  Pages: 62-70
- NAID
  40015691605
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] Roles of proteasome in DNA repair : impacts of proteasome inhibiotors on cancer therapy2008
- Author(s)
  Akira Motegi, Yasuhiro Murakawa, and Shunichi Takeda
- Journal Title
  
  Cancer lett (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] ユビキチン化によるDNA修復の制御機構2007
- Author(s)
  茂木章、村川泰裕、武田俊一
- Journal Title
  
  細胞工学 26(11)
  
  Pages: 1290-1295
- NAID
  40015691605
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] ユビキチン化によるDNA修復の制御機構2007
- Author(s)
  茂木章, 村川泰裕, 武田俊一
- Journal Title
  
  細胞工学 26(11)
  
  Pages: 1290-1295
- NAID
  40015691605
- Data Source
  KAKENHI-PROJECT-19810007
[Journal Article] Multiple geneticmanipulations of DT40 cell line
- Author(s)
  Motegi A, Takata M
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22510059
[Presentation] ユビキチンリガーゼによるDNA損傷トレランスの制御機構2019
- Author(s)
  Akira Motegi
- Organizer
  日本核酸医薬学会生物セッション第4回サテライトシンポジウム2019
- Invited
- Data Source
  KAKENHI-PROJECT-17K00548
[Presentation] HDAC3 induces translocation of XPC from active gene promoters to DNA lesions alter UV irradiation to promote nucleotide excision repair2019
- Author(s)
  Hiroyuki Niida, Koji Nishimoto, Akira Motegi, Masatochi Kitagawa
- Organizer
  第62回日本影響学会大会
- Data Source
  KAKENHI-PROJECT-17K00548
[Presentation] PARI regulates stalled replication fork proessing to maintain genome stability upon replication stress in mice2017
- Author(s)
  Ayako L. Mochizuki, Ami Katanaya, Eri Hayashi, Mihoko Hosokawa, Emiko Moribe, Akira Motegi, Masamichi Ishiai,Minoru Takata, Gen Kondoh, Hitomi Watanabe, Norio Nakatsuji, and Shinichiro Chuma
- Organizer
  第89回日本遺伝学会大会
- Data Source
  KAKENHI-PROJECT-17K00548
[Presentation] CtIP is a novel biomarker for predicting the sensitivity of breast cancers to PARP inhibitors2016
- Author(s)
  Akira Motegi,Junhui Wang, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
- Organizer
  The 2nd RBC-CEA Joint Workshop
- Place of Presentation
  京都大学 (京都市)
- Year and Date
  2016-04-11
- Data Source
  KAKENHI-PROJECT-25340030
[Presentation] PARP-1 and PARG promote genomic integrity by regulating resection of DNA double-strand breaks2015
- Author(s)
  Akira Motegi,Junhui Wang, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25340030
[Presentation] PARP-1 and PARG regulate 53BP1 to control DNA end resection2015
- Author(s)
  Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25340030
[Presentation] PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP2013
- Author(s)
  Junhui Wang, Akira Motegi, HIroaki Fujimori, Yoshio Miki, Mitsuko Masutani
- Organizer
  The 72nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-25340030
[Presentation] DNA損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析2010
- Author(s)
  足立淳、鳴海良平、佐野聖三、久家貴寿、白水崇、松本雅記、中山敬一、茂木章、井倉毅、高田穣、朝長毅
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22510059
[Presentation] Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks, Gordon Research Conference2009
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, and Kyungjae Myung
- Organizer
  Mammalian DNA Repair
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human ubiquitin ligases HLTF and SHPRH prevents genomic instability from stalled replication forks, Gordon Research Conference2009
- Author(s)
  Hung-jiun Liaw, Akira Motegi, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, and Kyungjae Myung
- Organizer
  Mammalian DNA Repair
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks2009
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Dins, Jan H. J. Hoeijoakers, Kyungjae Myung
- Organizer
  Gordon Research Conference (Mammalian DNA Repair)
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Functional analysis of the ubiquitin ligase RNF8 in DNA repair2009
- Author(s)
  Saho Era, Yohei Kasaishi, Shunichi Takeda, Akira Motegi
- Organizer
  Keystone Symposia (Genome Instability and Repair)
- Place of Presentation
  Taos, NM, USA
- Year and Date
  2009-03-02
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks2009
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu. Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakprs, Shunichi Takeda, Kyungjae Myung
- Organizer
  The 6th International 3R Symposium 2008
- Place of Presentation
  Tsumagoi, Japan
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Chicken Rap80 promotes repair of toposiomerase II poison-induced DNA damage2009
- Author(s)
  Junko Iijima, Akira Motegi, Toru Fukushima, Yoshihito Taniguchi, Shunichi Takeda
- Organizer
  Gordon Research Conference (Mammalian DNA Repair)
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Chicken Rap80 promotes repair of toposiomerase II poison-induced DNA damage, Gordon Research Conference2009
- Author(s)
  Junko Iijima, Akira Motegi, Toru Fukushima, Yoshihito Taniguchi, and Shunichi Takeda
- Organizer
  Mammalian DNA Repair
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Functional analysis of the ubiquitin ligase RNF8 in DNA repair Keystone Symposia2009
- Author(s)
  Saho Era, Yohei Kasaishi, Shunichi Takeda, and Akira Motegi
- Organizer
  Genome Instability and Repair
- Place of Presentation
  Taos, NM, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human ubiquitin ligases HLTF and SHPRH prevents genomic instability from stalled replication forks2009
- Author(s)
  Hung-jiun Liaw, Akira Motegi, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova. Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, Kyungjae Myung
- Organizer
  Gordon Research Conference (Mammalian DNA Repair)
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human PTIP Is Implicated in a Late Step of Homologous Recombination-mediated Double Strand Breaks(DSBs)Repair2008
- Author(s)
  Xin Wang, Akira Motegi, and Shunichi Takeda
- Organizer
  The International Ataxia-Telangiectasia Workshop 2008
- Place of Presentation
  Otsu, Japan
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Lysine 63-linked polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks2008
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, Shunichi Takeda, and Kyungjae Myung
- Organizer
  The 6th International 3R Symposium 2008
- Place of Presentation
  Tsumagoi, Japan
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human post-replication repair pathway by the Rad5 homolog SHPRH in the suppression of genomic instability2008
- Author(s)
  Hungjiun Liaw, Akira Motegi, Kyoo-Young Lee, and Kyungjae Myung
- Organizer
  Keystone Symposia (Genome Instability and Repair)
- Place of Presentation
  Santa Fe, NM, USA
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human SHPRH and HLTF suppress genomic instability through the lysine-63-linked polyubiquitination of proliferating cell nuclear antigen(PCNA)2008
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Raman Sood, Helen Moinova, Sanford D. Markowitz, Pu Paul Liu, Kyungjae Myung, and Shunichi Takeda
- Organizer
  The International Ataxia-Telangiectasia Workshop2008
- Place of Presentation
  Otsu, Japan
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human SHPRH and HLTF suppress genomic instability through the lysine-63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA)2008
- Author(s)
  Akira Motegi, Hung-jiun Liaw, Raman Sood, Helen Moinova, Sanford D. Markowitz, Pu Paul Liu, Kyungjae Myung, Shumichi Takeda
- Organizer
  The International Ataxia-Telangiectasia Workshop
- Place of Presentation
  Otsu, Japan
- Year and Date
  2008-04-23
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] PTIP Is Implicated in a Late Step of Homologous Recombination-mediated Double Strand Breaks (DSBs) Repair2008
- Author(s)
  Xin Wang, Katsuya Takenaka, Akira Motegi, Shunichi Takeda
- Organizer
  The International Ataxia-Telangiectasia Workshop
- Place of Presentation
  Otsu, Japan
- Year and Date
  2008-04-24
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human SHPRH and HLTF suppress genome instability through PCNA polyubiquitination2007
- Author(s)
  Akira Motegi, Hungjiun Liaw, Kyoo-Young Lee, Shunichi Takeda, and Kyungjae Myung
- Organizer
  2007 Annual Meeting of Molecular Biology Society of Japan(Symposium)
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] Human SHPRH and HLTF suppress genomic instability through the lysine-63-linked polyubiquitination of PCNA2007
- Author(s)
  Akira Motegi
- Organizer
  The 30th Annual Meeting of MBSJ (BMB 2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-19810007
[Presentation] PARP-1 and PARG are both required for the regulation of 53BP1 after IR
- Author(s)
  Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
- Organizer
  The 73rd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25340030

1. TAKEDA Shunichi (60188191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. MASUTANI MITSUKO (60238904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Kitagawa Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 三木義男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 北川恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Motegi Akira 茂木 章

MOTEGI Akira 茂木 章

Research Projects

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Analysis of DNA-damage-tolerance mechanisms that facilitate restart of stalled DNA replicationPrincipal Investigator

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Analysis of regulatory mechanisms of DNA repair by ubiquitinationPrincipal Investigator

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Analysis of DNA damage response using gene-disrupted DT40 clones.

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Ubiquitin-dependent regulation of DNA replication arrestPrincipal Investigator

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[Journal Article] HDAC3 is required for XPC recruitment and nucleotide excision repair of DNA damage induced by UV irradiation2020

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[Journal Article] Aberrations in DNA repair pathways in cancer and therapeutic significances2019

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[Journal Article] PARI regulates stalled replication fork proessing to maintain genome stability upon replication stress in mice2017

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[Journal Article] Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair2017

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[Journal Article] Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.2016

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[Journal Article] Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end-joining2015

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[Journal Article] Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end-joining2015

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[Journal Article] Multiple genetic manipulations of DT40 cell line2014

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[Journal Article] Multiple genetic manipulations of DT40 cell line2013

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Motegi Akira 茂木章

MOTEGI Akira 茂木章