WANG Wei 王偉

Researcher Number	80467117
External Links
Affiliation (based on the past Project Information) *help	2010 – 2011: Kanazawa University, がん研究所, 博士研究員 2009 – 2010: Kanazawa University, がん研究所, 研究員
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 上皮成長因子受容体 / MET / ゲフィチニブ / 線維芽細胞 / 肝細胞増殖因子 / 薬剤耐性 / 分子標的治療 / 肺癌 Except Principal Investigator ゲフィチニブ / 上皮成長因子受容体 … More / 線維芽細胞 / MET / 肝細胞増殖因子 / 公子標的治療 / PI3K / バイオマーカー / EGFR遺伝子変異 / Met / HGF / 薬剤耐性 / EGFR-TKI / 肺癌 Less

Development of individual therapy for overcoming HGF-induced molecular targeted drug-resistance in EGFR-mutant lung cancer
- Principal Investigator
  
  YANO Seiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kanazawa University
Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorsPrincipal Investigator
- Principal Investigator
  
  WANG Wei
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kanazawa University

All 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] E7050, a Met kinase inhibitor, reverses three different mechanisms of hepatocyte growth factor-induced resistance to tyrosine kinase inhibitors in EGFR mutant lung cancer cells2012
- Author(s)
  Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Uenaka T, Yano S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18 Issue: 6 Pages: 1663-71
- DOI
  10.1158/1078-0432.ccr-11-1171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23790327, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-24390210
[Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer2011
- Author(s)
  Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Issue: 8 Pages: 2260-9
- DOI
  10.1158/1078-0432.ccr-10-1993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] Pleural mesothelioma instigates tumor associated fibroblasts to promote prog-ression via malignant cytokine network2011
- Author(s)
  Li Q, Wang W, Yamada T, Matsumoto K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yano S.
- Journal Title
  
  Am J Pathol
  
  Volume: 179 Issue: 3 Pages: 1483-93
- DOI
  10.1016/j.ajpath.2011.05.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23659434, KAKENHI-PROJECT-23790221, KAKENHI-PROJECT-23790902
[Journal Article] The EGFR ligands amphiregulin and heparin-binding EGF-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer2011
- Author(s)
  Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Takeuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Issue: 11 Pages: 3619-30
- DOI
  10.1158/1078-0432.ccr-10-2475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23591921, KAKENHI-PROJECT-23790902
[Journal Article] Genetically engineered humanized anti-ganglioside GM2 anti-body against multiple organ metastasis produced by GM2 expressing small cell lung cancer2011
- Author(s)
  Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W, Akinaga S, Nishioka Y, Sone S, Yano S.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 12 Pages: 2157-63
- DOI
  10.1111/j.1349-7006.2011.02093.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor2011
- Author(s)
  Ogino H, Hanibuchi M, Kakiuchi S, Trung Van The, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 10 Issue: 7 Pages: 1218-28
- DOI
  10.1158/1535-7163.mct-10-0707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.2011
- Author(s)
  Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S.
- Journal Title
  
  Clin Cancer Res(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer.2011
- Author(s)
  Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17 Pages: 2260-2269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.2010
- Author(s)
  Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sone S, Yano S.
- Journal Title
  
  Clin Cancer Res 16
  
  Pages: 174-83
- NAID
  120001939468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.2010
- Author(s)
  Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sekido Y, Sone S, Yano S.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 16 Pages: 174-183
- NAID
  120001939468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] Hepatocyte growth factor reduces susceptibility to irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer2010
- Author(s)
  Yamada T, Matsumoto K, Wang W, Li Q, NishiokaY, Sekido Y, Sone S, Yano S.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Issue: 1 Pages: 174-83
- DOI
  10.1158/1078-0432.ccr-09-1204
- NAID
  120001939468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] HM1.24 (CD317) is a novel target against lung cancer for immunothera py using anti-D41.24 antibody.2009
- Author(s)
  Wang W, et al.
- Journal Title
  
  Cancer Immunol Immunother 58
  
  Pages: 967-976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors2009
- Author(s)
  Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Issue: 21 Pages: 6630-8
- DOI
  10.1158/1078-0432.ccr-09-1001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Chimeric and humanized anti-HM1.24 antibodies mediate antibody-depe ndent cellular cytotoxicity against lung cancer cells.2009
- Author(s)
  Wang W, et al.
- Journal Title
  
  Lung Cancer 63
  
  Pages: 23-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] HM1.24(CD317)is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells.2009
- Author(s)
  Wang W, et al.
- Journal Title
  
  Lung Cancer 63
  
  Pages: 23-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EG FR tyrosine kinase inhibitors.2009
- Author(s)
  Wang W, et al.
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 6630-6638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  Wang W, et al.
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 6630-6638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S.
- Journal Title
  
  Clin Cancer Res. 15(21)
  
  Pages: 6630-6638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790768
[Journal Article] E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangio-genic cytokine production profiles2009
- Author(s)
  Ikuta K, Yano S, Trung TV, Hanibuchi M, Goto H, Li Q, Wang W, Yamada T, Ogino H, Kakiuchi S, Uehara H, Sekido Y, Uenaka T, Nishioka Y, Sone S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Issue: 23 Pages: 7229-37
- DOI
  10.1158/1078-0432.ccr-09-1980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] Stromal Fibroblasts Induce Resistance of Lung Cancer to EGFR Tyrosine Kinase Inhibitors.2010
- Author(s)
  Wei Wang, Qi Li, Tadaaki Yamada, Yasuhiko Nishioka, Saburo Sone, Seiji Yano
- Organizer
  第50回日本呼吸器学会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Novel gefitinib resistance mechanism and its therapeutic strategy for lung adenocarcinoma with EGF receptor activating mutations.2010
- Author(s)
  Wei Wang, Qi Li, Tadaaki Yamada, Yasuhiko Nishioka, Saburo Sone, Seiji Yano.
- Organizer
  第19回日本がん転移学会
- Place of Presentation
  金沢市文化ホール(石川県)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Therapeutic effect of HGF inhibitors against HGF-induced EGFR-TKI resistance in lung cancer harboring EGFR mutations.2010
- Author(s)
  Seiji Yano, Wei Wang, Qi Li, Ivan S.Donev, Shinji Takeuchi, Tadaaki Yamada, Kunio Matsumoto, Yasuhiko Nishioka, Saburo Sone
- Organizer
  AACR 101st Annual Meeting 2010.
- Place of Presentation
  Walter E.Washington Convension Center (USA)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Therapeutic effect of HGF inhibitors against HGF-induced EGFR-TKI resistance in lung cancer harboring EGFR mutations.2010
- Author(s)
  Seiji Yano, Wei Wang, Qi Li, Ivan S.Donev, Shinji Takeuchi, Tadaaki Yamada, Kunio Matsumoto, Yasuhiko Nishioka, Saburo Sone.
- Organizer
  AACR 101st Annual Meeting 2010.
- Place of Presentation
  WalterE.Washington Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Stromal Fibroblasts Induce Resistance of Lung Cancer to EGFR Tyrosine Kinase Inhibitors.2010
- Author(s)
  Wei Wang, Qi Li, Tadaaki Yamada, Yasuhiko Nishioka, Saburo Sone, Seiji Yano.
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] 宿主由来HGFによる変異型EGFR陽性肺癌のゲフィチニブ耐性機構解析とその克服.2009
- Author(s)
  王偉
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島市)
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] Stromal Fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  王偉
- Organizer
  2009 Asia-Paciffic Conference of Tumor Biology and Medicine
- Place of Presentation
  Hotel JianGuo, (Xian China)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] Stromal fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  Wei Wang, Qi Li, Tadaaki Yamada, Yasuhiko Nishioka, Saburo Sone, Seiji Yano.
- Organizer
  2009Asia-Pacific Conference of Tumor Biology and Medicine and Fourth Forum of Chinese Young and Middle-aged Oncologists.
- Place of Presentation
  Xi'An, Xian jianGuo Hotel (CHINA)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Stromal fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  王偉
- Organizer
  第13回日本がん分子標的治療学会
- Place of Presentation
  ホテルクレメント徳島(徳島市)
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Stromal fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  王偉
- Organizer
  第18回日本がん転移学会学術集会
- Place of Presentation
  旭川グランドホテル(旭川市)
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] Stromal fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  Wang W
- Organizer
  2009 Asia-Pacific Conference of Tumor Biology
- Place of Presentation
  JianGuo Hotel (Xi'An China)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Stromal fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.13^<th> Japanese Association for Molecular Target Therapy of Cancer.2009
- Author(s)
  Wei Wang, Qi Li, Tadaaki Yamada, Yasuhiko Nishioka, Saburo Sone, Seiji Yano.
- Organizer
  第13回日本がん分子標的治療学会
- Place of Presentation
  ホテルクレメント徳島(徳島県)
- Data Source
  KAKENHI-PROJECT-21790768
[Presentation] Stromal fibroblasts induce resistance of lung cancer to EGFR tyrosine kinase inhibitors.2009
- Author(s)
  Wei Wang, Qi Li, Tadaaki Yamada, Yasuhiko Nishioka, Saburo Sone, Seiji Yano.
- Organizer
  第18回日本がん転移学会
- Place of Presentation
  旭川グランドホテル(北海道)
- Data Source
  KAKENHI-PROJECT-21790768

1. YANO Seiji (30294672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. YAMADA Tadaaki (00507048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. TAKEUCHI Shinji (90565384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

WANG Wei 王 偉

Research Projects

Research Products

Co-Researchers

Development of individual therapy for overcoming HGF-induced molecular targeted drug-resistance in EGFR-mutant lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] E7050, a Met kinase inhibitor, reverses three different mechanisms of hepatocyte growth factor-induced resistance to tyrosine kinase inhibitors in EGFR mutant lung cancer cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pleural mesothelioma instigates tumor associated fibroblasts to promote prog-ression via malignant cytokine network2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The EGFR ligands amphiregulin and heparin-binding EGF-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetically engineered humanized anti-ganglioside GM2 anti-body against multiple organ metastasis produced by GM2 expressing small cell lung cancer2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.2011

Author(s)

Journal Title

Data Source

[Journal Article] Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer.2011

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Hepatocyte growth factor reduces susceptibility to irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer2010

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] HM1.24 (CD317) is a novel target against lung cancer for immunothera py using anti-D41.24 antibody.2009

Author(s)

Journal Title

Data Source

[Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors2009

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chimeric and humanized anti-HM1.24 antibodies mediate antibody-depe ndent cellular cytotoxicity against lung cancer cells.2009

WANG Wei 王偉