Oka Sugako 岡素雅子

… Alternative Names

OKA Sugako 岡素雅子

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Researcher Number	80467894
Other IDs
Affiliation (Current)	2025: 福岡国際医療福祉大学, 医療学部, 教授 2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 九州大学, 医学研究院, 共同研究員 2018 – 2019: 福岡歯科大学, 口腔歯学部, 客員准教授 2017: 九州大学, 生体防御医学研究所, 特任助教 2015: 九州大学, 生体防御医学研究所, 研究員 2014: 九州大学, 生体防御医学研究所, 学術研究員 … More 2010 – 2014: 九州大学, 生体防御医学研究所, 特任助教 2012: 九州大学, 生体防御医学研究所, その他 2010: 九州大学, 生体防御医学研究所, 学術研究員 2010: 九州大学, 生体防御研究所, 学術研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Neurology / Tumor biology Except Principal Investigator Risk sciences of radiation/Chemicals / Basic Section 59040:Nutrition science and health science-related / Sections That Are Subject to Joint Review: Basic Section45010:Genetics-related ,Basic Section45020:Evolutionary biology-related / Basic Section 45020:Evolutionary biology-related / Basic Section 45010:Genetics-related / Tumor biology
Keywords	Principal Investigator 酸化ストレス / ヒトiPS細胞 / 発がん / human iPS cell / Mitochondria / human iPS cell / ROS / Carcinogenesis / DNA酸化障害 / ミトコンドリア … More / 糖尿病 / インスリン抵抗性 / TFAM / アルツハイマー病 / ストレス / 癌 / 細胞死 / がん / シグナル伝達 / ゲノム / シグナル伝達と遺伝子発現 … More Except Principal Investigator DNA修復 / 酸化ストレス / 脱アミノ化ヌクレオチド / 酸化ヌクレオチド / 病態モデル / 化学物質 / 環境ストレス / ヌクレオチドプール / 放射線 / 心臓 / 幹細胞 / 老化 / DNA損傷 / 生殖細胞 / ゲノム変異 / 遺伝性腫瘍 / MUTYH / OGG1 / MTH1 / 8-オキソグアニン / エクソーム解析 / ミューテーターマウス / がんと遺伝 / 生殖細胞突然変異 / 環境スレス / アルツハイマー病 / 自然突然変異 / 細胞増殖阻害 / 酸化的損傷 / 神経変性 / 細胞死 / バイスタンダー効果 / 突然変異 / RNA / DNA / 活性酸素 Less

卵子が持つ精子DNA損傷を修復する能力の分子機構解明と次世代ゲノム影響の解析
- Principal Investigator
  
  大野みずき
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 45010:Genetics-related
  Basic Section 45020:Evolutionary biology-related
  Sections That Are Subject to Joint Review: Basic Section45010:Genetics-related ,Basic Section45020:Evolutionary biology-related
- Research Institution
  Kyushu University
心臓アンチエイジング薬の開発を目指したヒトiPS細胞由来老化心筋モデルの構築
- Principal Investigator
  
  日高京子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Kitakyushu
内在性酸化ストレス制御による発がん初期シグナル分子の同定Principal Investigator
- Principal Investigator
  
  岡素雅子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fukuoka Dental College
Clarification of the mechanism of germline mutation occurrence that causes familial tumor
- Principal Investigator
  
  SAKUMI KUNIHIKO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
hTFAM improves impaired insulin signaling in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  OKA SUGAKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress
- Principal Investigator
  
  NAKABEPPU YUSAKU
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
Regulation of MUTYH expression by p53 plays a critical role in cell deathPrincipal Investigator
- Principal Investigator
  
  OKA Sugako
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University

All 2023 2022 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression2022
- Author(s)
  Oka Sugako、Tsuzuki Teruhisa、Hidaka Masumi、Ohno Mizuki、Nakatsu Yoshimichi、Sekiguchi Mutsuo
- Journal Title
  
  Cell Death Discovery
  
  Volume: 8 Issue: 1 Pages: 150-150
- DOI
  10.1038/s41420-022-00961-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09915, KAKENHI-PROJECT-22K11733, KAKENHI-PROJECT-20H03254
[Journal Article] ROS control in human iPS cells reveals early events in spontaneous carcinogenesis2019
- Author(s)
  Sugako Oka, Michio Hayashi, Kenichi Taguchi, Masumi Hidaka, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Journal Title
  
  Carcinogenesis
  
  Volume: なし Pages: 1-8
- DOI
  10.1093/carcin/bgz081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07250
[Journal Article] Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis.2017
- Author(s)
  Takemori C, Kunisada M, Yogianti F, Oka S, Sakumi K, Ono R, Nakabeppu Y, Nishigori C.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 85 Issue: 2 Pages: 140-143
- DOI
  10.1016/j.jdermsci.2016.10.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10126, KAKENHI-PROJECT-17K19913, KAKENHI-PROJECT-15H04298
[Journal Article] Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.2016
- Author(s)
  S. Oka, J. Leon, K. Sakumi, T. Ide, D. Kang, F.M. LaFerla, and Y. Nakabeppu
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 37889-37889
- DOI
  10.1038/srep37889
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-15K15085
[Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016
- Author(s)
  Julio, Leon, Sakumi Kunihiko, Castillo Erika, Sheng Zijing, Oka Sugako, Nakabeppu Yusaku.
- Journal Title
  
  Scientific Reports
  
  Volume: 25 Issue: 1 Pages: 22086-22086
- DOI
  10.1038/srep22086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-25461281
[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.2015
- Author(s)
  Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 127 Issue: 4 Pages: 446-455
- DOI
  10.1016/j.jphs.2015.03.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-26340025, KAKENHI-PUBLICLY-15H00897, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25460334
[Journal Article] 8-oxoguanine causes spontaneous de novo germline mutations in mice.2014
- Author(s)
  Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., and Nakabeppu, Y.
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 4689-4689
- DOI
  10.1038/srep04689
- NAID
  120005703609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25241016
[Journal Article] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death2014
- Author(s)
  Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y
- Journal Title
  
  Oncogenesis
  
  Volume: 3 Issue: 10 Pages: 1-10
- DOI
  10.1038/oncsis.2014.35
- NAID
  120005703608
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281
[Journal Article] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice.2014
- Author(s)
  Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., and Sasaguri, T.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: N/A Issue: 3 Pages: 340-348
- DOI
  10.1016/j.bcp.2014.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26340025
[Journal Article] Altered expression of diabetes-related genes in Alzheimer's disease brains: the hisayama study2014
- Author(s)
  Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y
- Journal Title
  
  Cereb Cortex
  
  Volume: 24 Issue: 9 Pages: 2476-2488
- DOI
  10.1093/cercor/bht101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24591720, KAKENHI-PROJECT-25461281
[Journal Article] Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains.2014
- Author(s)
  Hamasaki, H., Honda, H., Suzuki, S.O., Hokama, M., Kiyohara, Y., Nakabeppu, Y., and Iwaki, T.
- Journal Title
  
  Neuropathology
  
  Volume: N/A Issue: 3 Pages: 284-290
- DOI
  10.1111/neup.12095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24650186, KAKENHI-PROJECT-25430050, KAKENHI-PROJECT-26290017
[Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB induced skin inflammatory responses and carcinogenesis.2014
- Author(s)
  Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., and Nishigori, C.
- Journal Title
  
  J Invest Dermatol
  
  Volume: N/A Issue: 10 Pages: 2610-2619
- DOI
  10.1038/jid.2014.188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281, KAKENHI-PROJECT-25461668
[Journal Article] Altered expression of diabetes-related genes in Alzheimer’s disease brains: The Hisayama study2013
- Author(s)
  Hokama, M., S. Oka, J. Leon, T. Ninomiya, H. Honda, K. Sasaki, T. Iwaki, T. Ohara, T. Sasaki, F.M. LaFerla, Y. Kiyohara, and Y. Nakabeppu.
- Journal Title
  
  Cereb Cortex
  
  Volume: 23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.2013
- Author(s)
  suji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M., and Sado, T.
- Journal Title
  
  J Radiat Res
  
  Volume: 54 Issue: 3 Pages: 453-466
- DOI
  10.1093/jrr/rrs128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration.2012
- Author(s)
  Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T.
- Journal Title
  
  Am J Pathol
  
  Volume: 181 Issue: 4 Pages: 1378-1386
- DOI
  10.1016/j.ajpath.2012.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24249083
[Journal Article] 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.2012
- Author(s)
  Sheng, Z., et. al.
- Journal Title
  
  The Journal of clinical investigation
  
  Volume: 122 Issue: 12 Pages: 4344-4361
- DOI
  10.1172/jci65053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004
[Journal Article] MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration2012
- Author(s)
  Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T
- Journal Title
  
  Am J Pathol
  
  Volume: 181(4) Pages: 1378-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501014
[Journal Article] 8-Oxoguanine causes neurodegeneration during Mutyh-mediated DNA base excision repair2012
- Author(s)
  Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K, Yamada H, Nakabeppu Y
- Journal Title
  
  J Clin Invest
  
  Volume: 12 Pages: 4344-4361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501014
[Journal Article] A DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.2011
- Author(s)
  Oka, S., Y.Nakabeppu.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 677-682
- NAID
  10029291748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis2011
- Author(s)
  Oka S, Nakabeppu Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 4 Pages: 677-682
- DOI
  10.1111/j.1349-7006.2011.01869.x
- NAID
  10029291748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22501014
[Journal Article] FosB Is Essential for the Enhancement of Stress Tolerance and Antagonizes Locomotor Sensitization by ΔFosB2011
- Author(s)
  Ohnishi YN, et.al.
- Journal Title
  
  Biological Psychiatry
  
  Volume: 70-5 Issue: 5 Pages: 487-495
- DOI
  10.1016/j.biopsych.2011.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23657116
[Journal Article] A Role for SNX1 in the Regulation of EGF-Dependent Phosphorylated EGFR Endocytosis Via the Early/Late Endocytic Pathway in a Gefitinib-Sensitive Human Lung Cancer Cells2011
- Author(s)
  Nishimura Y, Yoshioka K, Takiguchi S, Bereczky B, Nakabeppu Y, Itoh K
- Journal Title
  
  Curr.Signal Transduct.Ther.
  
  Volume: 6 Issue: 3 Pages: 383-395
- DOI
  10.2174/157436211797484047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
- Author(s)
  Nakabeppu, Y., S.Oka, Z.Sheng, D.Tsuchimoto, K.Sakumi.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 51-58
- NAID
  120005227112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
- Author(s)
  Sarah A. Martin, Nuala McCabe, Michelle Mullarkey, Robert Cummins, Darren J. Burgess, Y Nakabeppu, S Oka, Elaine Kay, Christopher J. Lord and Alan Ashworth
- Journal Title
  
  Cancer Cell
  
  Volume: 17 Pages: 235-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] 内在性酸化ストレス制御ヒトiPS細胞を用いた心筋細胞老化モデルの樹立2023
- Author(s)
  岡素雅子，李俊，王苑犁，鷹野典子，大野みずき，李鍾國，日高京子
- Organizer
  第46回日本生物学会年会
- Data Source
  KAKENHI-PROJECT-22K11733
[Presentation] DNA 修復欠損マウスを利用した心臓老化関連変異の探索2023
- Author(s)
  日高京子，岡寿雅子，鷹野典子，李鍾國，大野みずき
- Organizer
  日本環境変原ゲノム学会第52回大会
- Data Source
  KAKENHI-PROJECT-22K11733
[Presentation] Establishment of cancer cell models derived from human iPS cells based on mitochondrial complex II deficiency2018
- Author(s)
  Sugako Oka, Michio Hayashi, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] Establishment of cancer cell models derived from human iPS cells based on mitochondrial complex II deficiency2018
- Author(s)
  Sugako Oka, Michio Hayashi, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Organizer
  北京シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] ミトコンドリア複合体II不全によるヒトiPS細胞由来発がんモデルの構築2018
- Author(s)
  岡素雅子、林道夫、関口睦夫
- Organizer
  JEMS公開シンポジウム(日本環境変異学会主催)、「＜若手企画＞遺伝毒性研究の最前線と挑戦」
- Invited
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] ミトコンドリア複合体II不全によるヒトiPS細胞由来発がんモデルの構築2018
- Author(s)
  岡素雅子、林道夫、續輝久、関口睦夫
- Organizer
  第18回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] ミトコンドリア呼吸鎖複合体不全によるヒトiPS細胞由来がん細胞モデル2018
- Author(s)
  岡素雅子、林道夫、田口健一、續輝久、関口睦夫
- Organizer
  第41回日本分子生物学会ワークショップ企画［1PW2-14 ヒトiPS細胞を用いた発がん初期過程の解析］
- Invited
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] Cell death induced by MUTYH-initiated base excision repair plays a role in p53-mediated tumor suppression2016
- Author(s)
  岡素雅子、フリオレオン、土本大介、作見邦彦、中別府雄作
- Organizer
  平成 27 年度「個体レベルでのがん研究支援活動」ワークショップ
- Place of Presentation
  大津
- Year and Date
  2016-02-03
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016
- Author(s)
  岡素雅子, 盛子敬, フリオレオン, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs2015
- Author(s)
  Sugako Oka, Ohno Mizuki, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  BIT’ 8th, Annual World Cancer Congress-2015
- Place of Presentation
  Beijing, China
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) breaks the vicious circle of oxidative stress and amyloid β accumulation in triple-transgenic mouse model of Alzheimer’s disease2015
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  第38回日本分子生物学会年会, 第88回日本生化学会　合同大会　(神戸)
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] MUTYHによる塩基除去修復過程に依存して誘導される細胞死はp53の発がん抑制機構の１つとして機能する2015
- Author(s)
  岡素雅子, フリオレオン, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第44回日本環境変異学会
- Place of Presentation
  福岡
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] 活性酸素によるDNA損傷が引起こすさまざまな生命現象：突然変異から神経変性まで2015
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 大野みずき, 土本大介, 作見邦彦
- Organizer
  第17回日本進化学会年大会
- Place of Presentation
  東京
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] Cortical neurons isolated from adult Mth1/Ogg1-double-knockout mouse exhibit impaired neurite regeneration under conditions of oxidative stress2015
- Author(s)
  Julio Jesusu Leon Incio, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
- Organizer
  The 38th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] MUTYH-dependent programmed cell death triggered by 8-oxoguanine and its implication in tumor suppression and neurodegeneration2015
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  15th International Congress of Radition Research: ICRR2015
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2015-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] 8-Oxoguanine accumulated in mitochondrial DNA disturbs neuritic regeneration of cultured adult mouse cortical neurons under conditions of oxidative stress2015
- Author(s)
  Julio Leon, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
- Organizer
  45th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04298
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  EUROMIT2014 International Meeting on Mitochondrial Pathology
- Place of Presentation
  TAMPERE FINLAND
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] 8-oxo-dGTP generated in nucleotide pools is a major cause of neurodegeneration under oxidative stress.2014
- Author(s)
  Sheng Zijing, Sugako Oka, Yasuhiro Ikeda, Margherita Bignami, Yusaku Nakabeppu
- Organizer
  International symposium "New Frontier of Molecular Neuropathology 2014"
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer’s disease mouse model2013
- Author(s)
  Yoriko Akimoto, Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Striatal degeneration initiated by a mitochondrial toxin, 3-nitropropionic acid is dependent on MUTYH-initiated base excision repair of 8-oxoguanine-paired adenine.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair2013
- Author(s)
  38. Zing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Gordon research conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidative damage in brain genomes and neuroprotective mechanisms.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice.2013
- Author(s)
  岡素雅子, Julio Leon, 外間政朗, 加藤木敦央, 作見邦彦, 井手友美, Kang Dongchon, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常：久山町研究2013
- Author(s)
  外間政朗，岡素雅子，Julio Leon，二宮利治，本田裕之，佐々木健介，岩城徹，小原知之，清原裕，中別府雄作
- Organizer
  第18回日本神経精神医学会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study.2013
- Author(s)
  中別府雄作, 外間政朗, 岡素雅子, Julio Leon, 二宮利治, 本田裕之, 佐々木健介, 岩城徹, 小原知之, Frank M. LaFerla, 清原裕
- Organizer
  包括的脳科学研究推進支援ネットワーク平成25年度夏のワークショップ
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer's disease mouse model.2013
- Author(s)
  Yoriko Akimoto, Sugako Oka, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice.2013
- Author(s)
  Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi, Sakumi Kunihiko, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-dependent neurodegeneration initiated by mitochondrial accumulation of 8-oxoguanine in neurons is efficiently suppressed by MTH1 and OGG12013
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  10th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 核酸損傷と生体防御2013
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 土本大介, 作見邦彦
- Organizer
  第24回日本生体防御学会学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2013
- Author(s)
  Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via caspase-independent cell death pathway2013
- Author(s)
  岡素雅子, 中別府雄作
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cytotoxic effects of X-ray irradiation on proliferating and differentiated human neuroblastoma cell line SH-SY5Y, and their modulation by BDNF and inhibitors for CDK5 and calpains.2013
- Author(s)
  Erika Castillo, Julio Leon, 秋本頼子, 作見邦彦, 岡素雅子, 土本大介, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2013
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi & Yusaku Nakabeppu
- Organizer
  Gordon Research Conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cross-talk between insulin and other growth factors signaling regulate their neuroprotective functions.2013
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Erika Castillo, Yusaku Nakabeppu
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice2013
- Author(s)
  Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Synergistic interaction between insulin and other growth factors modulates their neuroprotective functions.2012
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine causes complex neurodegeneration in a MUTYH-dependent manner, which can be efficiently suppressed by MTH1 and/or OGG1.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  Yumebutai, Awaji, Hyogo
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスは MUTYH による塩基除去修復経路を介してcalpain/PARP 依存性の神経変性を引き起こす.2012
- Author(s)
  盛子敬，岡素雅子，土本大介，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cytotoxic effects of X-ray irradiation on proliferative and differentiated human neuroblastoma cell line, SH-SY5Y, and modulation by neurotrophic factors and CDK5 inhibitor.2012
- Author(s)
  Erika Castillo, Julio Leon, Yoriko Akimoto, Yasuto Yoneshima, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 9th ASMRM and Chinese Mit'2012
- Place of Presentation
  Beijing, China
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cooperative neuroprotection by insulin and neurotrophic factors.2012
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Obesity and altered expression of genes related to Diabetes-mellitus in Alzheimer’s disease mouse model.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2012
- Author(s)
  Sugako Oka, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本がん疫学分子疫学学会
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Obesity and altered expression of genes related to diabetes mellitus in a transgenic mouse model of Alzheimer's disease.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである.2012
- Author(s)
  岡素雅子，レオンフリオ，土本大介，作見邦彦，中別府雄作
- Organizer
  第35回日本がん疫学・分子疫学研究会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2012
- Author(s)
  岡　素雅子
- Organizer
  第35回日本がん疫学　分子疫学学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Alzheimer’s disease mouse model exhibits altered expression of genes related to diabetes-mellitus with obesity.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性酸素による核酸の修飾とゲノム応答の遺伝学.2012
- Author(s)
  中別府雄作，土本大介，盛子敬，岡素雅子，作見邦彦
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair by MUTYH initiates calpain/PARP-dependent neurodegeneration under oxidative stress.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2011
- Author(s)
  中別府雄作, 猪山輝昭, 岡素雅子, 盛子敬, 作見邦彦, 土本大介
- Organizer
  第2回 Molecular Cardiovascular Conference
- Place of Presentation
  余市(招待講演)
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本環境変異原学会第40回大会 (シンポジウム)
- Place of Presentation
  東京
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Roles of insulin in survival and proliferation of SH-SY5Y neuroblastoma cells under neuronal differentiation2011
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである2011
- Author(s)
  岡素雅子, レオンフリオ, 作見邦彦, 土木大介, 中別府雄作
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs2011
- Author(s)
  Sugako Oka
- Organizer
  Keystone Symposia Stem Cells, Cancer and Metastasis
- Place of Presentation
  Keystone, CO, USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本環境変異原学会第40回大会シンポジウム発表
- Place of Presentation
  東京一橋記念講堂
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAsKeystone Symposia Stem Cells2011
- Author(s)
  Sugako Oka, Yusaku Nakabeppu
- Organizer
  Cancer and Metastasis
- Place of Presentation
  USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Gene expression prefiling of postmortem brains of patients with Alzheimer's disease pathology : The Hisayama Study2011
- Author(s)
  M.Hokama, T.Iwaki, K.Sasaki, Y.Kiyohara, T.Sasaki, Y.Nakabeppu
- Organizer
  41^<st> Annual meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYHはp53による発がん抑制のメディエータである2011
- Author(s)
  岡素雅子, フリオレオン, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第40回日本環境変異原学会シンポジウム
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会口頭、ポスター
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2011
- Author(s)
  Sugako Oka, Yusaku Nakabeppu
- Organizer
  Keystone Symposia on Stem Cells, Cancer and Metastasis
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスはDNA修復酵素MUTYHに依存して神経変性を引き起こす2011
- Author(s)
  盛子敬, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第4回Kyushu CVD Conference
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs2010
- Author(s)
  Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  国際3R会議
- Place of Presentation
  富山
- Year and Date
  2010-10-27
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2010
- Author(s)
  Sugako Oka, Zijing Sheng, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2010
- Author(s)
  Sugako Oka
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪,大阪国際会議場(ポスター)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートピアアイランド(ポスター口頭発表)
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態2010
- Author(s)
  中別府雄作, 猪山輝昭, Nona Abolhassani, 太田詠子, 盛子敬, 岡素雅子, 作見邦彦, 土本大介
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子, 中別府雄作
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quality control in the purine nucleotide pools is essential for maintaining genomic integrity in mammals.2010
- Author(s)
  Yusaku Nakabeppu, Nona Abolhassani, Teruaki Iyama, Zijing Sheng, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair-mediated programmed cell death and neurodegeneration2010
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  3rd International Genome Dynamics in Neurosciences Conference "DNA Repair and Neurological disease"
- Place of Presentation
  Brighton, UK
- Year and Date
  2010-07-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs2010
- Author(s)
  Sugako Oka
- Organizer
  進化する国際3R会議
- Place of Presentation
  富山,富山国際会議場(ポスター)
- Year and Date
  2010-10-27
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子, フリオレオン, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mitochondrial toxin, 3-nitropropionic acid induces striatal degeneration through the two distinct MUTYH-dependent cell death pathways.2010
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子、レオンフリオ、中別府雄作
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2010
- Author(s)
  Sugako Oka, Yusaku Nakabeppu
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻に起因するゲノム障害とその防御機構2010
- Author(s)
  中別府雄作, Nona Abolhassani, 猪山輝昭, 太田詠子, 盛子敬, 岡素雅子, 土本大介, 作見邦彦
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 放射線照射によって生成される損傷プリンヌクレオシドの同定と定量
- Author(s)
  秋本頼子, Nona Abolhassani, Erika Castillo, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease
- Author(s)
  Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  第27回変異機構研究会
- Place of Presentation
  愛知
- Year and Date
  2014-06-21 – 2014-06-22
- Invited
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi1, Kunihiko Sakumi, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  日本　東京
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Dongchon Kang
- Organizer
  The 3rd International Conference and Exhibition on Neurology & Therapeutics
- Place of Presentation
  Philadelphia, PA，U. S. A.
- Year and Date
  2014-09-08 – 2014-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka1, Julio Leon, Masaaki Hokama, Atsuhisa Katogi1, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  日本　神戸
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  The 14th Annual Conference of Japanese Society of Mitochondrial Research and Medicine
- Place of Presentation
  福岡
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  岡素雅子, Julio Leon, 加藤木敦央, Erika Castillo, Nona Abolhassani, 作見邦彦, 井手友美, 康東天, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease
- Author(s)
  岡素雅子, 康東天, 中別府雄作
- Organizer
  変異機構研究会第27回夏の学校
- Place of Presentation
  小牧
- Year and Date
  2014-06-21 – 2014-06-22
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb遺伝子産物はマクロファージにおける補体C5a受容体遺伝子，C5ar1とC5ar2の発現を制御する
- Author(s)
  森岡紀子, 能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Interspecies comparative gene expression profiling revealed impaired insulin production and insulin signaling accompanied by mitochondrial dysfunction in Alzheimer's disease brains: The Hisayama Study
- Author(s)
  Sugako Oka, Julio Leon, Nona Abolhassani, Masaaki Hokama, Toru Iwaki, Yutaka Kiyohara, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  第88回薬理学会年会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanisms of genetic diversity and programed cell death induced by 8-oxoguanine in mammals
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  9th ３R (Replication, Repair, recombination) symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-11 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Impaired insulin production and insulin signaling accompanied by mitochondrial dysfunction in Alzheimer's disease brains: The Hisayama Study
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Julio Leon, Nona Abolhassani, Masaaki Hokama, Toru Iwaki, Yutaka Kiyohara, Dongchon Kang
- Organizer
  包括型脳科学研究推進支援ネットワーク・冬のシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease
- Author(s)
  Sugako Oka, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  The Alzheimer’s Association International Conference in Boston, United States, 2013.
- Place of Presentation
  BOSTON USA
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] MUTYH-dependent programed cell death induced by 8-oxoguanine accumulated in cellular DNAs and its implication in tumorigenesis and neruodegeneration
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  鳴門
- Year and Date
  2014-10-28 – 2014-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  Neuro2013
- Place of Presentation
  日本　京都
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Impaired insulin production/signaling accompanied by mitochondrial dysfunction and oxidative stress in Alzheimer's disease brains
- Author(s)
  Sugako Oka, Julio Leon, Masaaki Hokama, Toru Iwaki, Yutaka Kiyohara, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  Progress 100: Kyushu-U and Stanford-U Joint Research and Education Program: First Symposium: From Genes to Human Diseases
- Place of Presentation
  福岡
- Year and Date
  2015-03-16 – 2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Characterization of transcript variants expressed in Alzheimer’s disease brains with human transcriptome array and deep RNA sequencing analyses: The Hisayama Study
- Author(s)
  Nona Abolhassani, Masasaki Hokama, Toru Iwaki, Yutaka Kiyohara, Yusaku Nakabeppu
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  International Meeting on Mitochondrial Pathology
- Place of Presentation
  Tampere，Finland
- Year and Date
  2014-06-15 – 2014-06-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  EuroMit International Meeting on Mitochondrial Pathology 2014
- Place of Presentation
  Finland,
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常とその意義：久山町研究
- Author(s)
  外間正朗, 岡素雅子, Julio Leon, 二宮利治, 本田裕之, 佐々木健介, 岩城徹, 小原知之, 清原裕, 中別府雄作
- Organizer
  56回歯科基礎医学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物ゲノムにおける8-オキソグアニンの修復プロセッシングと細胞運命
- Author(s)
  岡素雅子, 盛子敬, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  岡素雅子, Julio Leon, 加藤木敦央, 作見邦彦, 井手友美, 康東天, 中別府雄作
- Organizer
  第14回日本ミトコンドリア学会年会
- Place of Presentation
  福岡
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHによって開始される塩基除去修復に依存した２つの独立したプログラム細胞死の経路
- Author(s)
  岡素雅子, 盛子敬, 中別府雄作
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-22221004

1. NAKABEPPU YUSAKU (30180350)

# of Collaborated Projects: 4 results

# of Collaborated Products: 98 results
2. SAKUMI Kunihiko (50211933)

# of Collaborated Projects: 3 results

# of Collaborated Products: 50 results
3. TSUCHIMOTO Daisuke (70363348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
4. SHENG Zijing (90467895)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
5. 大野みずき (70380524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 日高京子 (00216681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. AKIMOTO Yoriko (50613254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. OHYAGI Yasumasa (30301336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KANG DONGCHON (80214716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. 関口睦夫 (00037342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 林道夫 (40447371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 鷹野典子 (30840318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山内一己 (40415419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 香崎正宙 (90717977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 国定充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 日高真純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oka Sugako 岡 素雅子

OKA Sugako 岡 素雅子

Research Projects

Research Products

Co-Researchers

卵子が持つ精子DNA損傷を修復する能力の分子機構解明と次世代ゲノム影響の解析

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心臓アンチエイジング薬の開発を目指したヒトiPS細胞由来老化心筋モデルの構築

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内在性酸化ストレス制御による発がん初期シグナル分子の同定Principal Investigator

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Review Section

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Clarification of the mechanism of germline mutation occurrence that causes familial tumor

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hTFAM improves impaired insulin signaling in Alzheimer's diseasePrincipal Investigator

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Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress

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環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明

Principal Investigator

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Regulation of MUTYH expression by p53 plays a critical role in cell deathPrincipal Investigator

Principal Investigator

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[Journal Article] Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression2022

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[Journal Article] ROS control in human iPS cells reveals early events in spontaneous carcinogenesis2019

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[Journal Article] Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis.2017

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[Journal Article] Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.2016

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[Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016

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[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.2015

Author(s)

Oka Sugako 岡素雅子

OKA Sugako 岡素雅子