Hagihara Hideo 萩原英雄

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HAGIHARA Hideo 萩原英雄

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Researcher Number	80514504
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医科学研究センター, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 藤田医科大学, 医科学研究センター, 講師 2018 – 2021: 藤田医科大学, 総合医科学研究所, 講師 2017: 藤田保健衛生大学, 総合医科学研究所, 助教 2016 – 2017: 藤田保健衛生大学, 総合医科学研究所, 講師 2014 – 2015: 藤田保健衛生大学, 総合医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurophysiology / General neuroscience / Medium-sized Section 46:Neuroscience and related fields Except Principal Investigator Basic / Social brain science / Experimental psychology
Keywords	Principal Investigator 乳酸修飾 / 脳 / 精神神経疾患 / モデル動物 / 神経精神疾患 / 精神疾患 / 海馬 / 統合失調症 / 乳酸化 / 翻訳後修飾 … More / マウス / 神経細胞 / タンパク質乳酸修飾 / 精神疾患モデル動物 / 脳内中間表現型 / 精神疾患モデル / 乳酸 / pH / 脳pH / アストロサイト / マイクロアレイ / 精神疾患モデルマウス / モデルマウス / 神経細胞成熟異常 / 海馬歯状回 … More Except Principal Investigator 神経科学 / バイオテクノロジー / 遺伝学 / トランスレーショナルリサーチ / 細胞・組織 / 脳神経疾患 / 脳・神経 / 神経成熟度 / Shn2欠損マウス / 3D電顕コネクトーム / 網羅的行動解析 / バイオインフォマティクス / 非成熟歯状回 / 神経活動操作 / 光遺伝学 / 神経活動 / マウス / 脳機能行動解析 / 成熟 / 神経細胞 / 歯状回 Less

アストロサイトの炎症応答におけるタンパク質乳酸修飾の機能推定Principal Investigator
- Principal Investigator
  
  萩原英雄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Fujita Health University
Protein lactylation in the brains of animal models of neuropsychiatric disordersPrincipal Investigator
- Principal Investigator
  
  萩原英雄
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Fujita Health University
Brain pH in animal models of neuropsychiatric disordersPrincipal Investigator
- Principal Investigator
  
  Hagihara Hideo
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Fujita Health University
Maturation abnormalities of astrocytes in the brain of mouse model of psychiatric disordersPrincipal Investigator
- Principal Investigator
  
  Hagihara Hideo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Fujita Health University
Time-course analysis of gene expression patterns in the brain of a mouse model of schizophrenia during postnatal developmentPrincipal Investigator
- Principal Investigator
  
  HAGIHARA Hideo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Fujita Health University
Exploring the relationship between altered neuronal maturation state in the hippocampal dentate gyrus and behavior
- Principal Investigator
  
  SHOJI Hirotaka
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental psychology
- Research Institution
  Fujita Health University
Elucidation and regulation of bi-directional changes in neuronal maturation status
- Principal Investigator
  
  Miyakawa Tsuyoshi
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic / Social brain science
- Research Institution
  Fujita Health University

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment2024
- Author(s)
  Hideo Hagihara、Takao Keizo、他129名
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 89376-89376
- DOI
  10.7554/elife.89376
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17422, KAKENHI-PROJECT-21K19314, KAKENHI-PROJECT-23K18168, KAKENHI-PROJECT-22K06493, KAKENHI-PROJECT-23K05612, KAKENHI-PROJECT-23K05860, KAKENHI-PROJECT-23K06119, KAKENHI-PROJECT-23K06338, KAKENHI-PROJECT-23K06399, KAKENHI-PROJECT-22K19281, KAKENHI-PROJECT-18K15457, KAKENHI-PROJECT-18H04016, KAKENHI-PROJECT-20H00491, KAKENHI-PROJECT-20H00492, KAKENHI-PLANNED-20H05895, KAKENHI-PUBLICLY-22H05614, KAKENHI-PUBLICLY-23H04227, KAKENHI-PLANNED-23H04951, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-19H03538, KAKENHI-PROJECT-23K21457, KAKENHI-PROJECT-23K23801, KAKENHI-PROJECT-23K23816, KAKENHI-PROJECT-23K27324
[Journal Article] Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions2021
- Author(s)
  Hagihara Hideo、Shoji Hirotaka、Miyakawa Tsuyoshi、International Brain pH Project Consortium
- Journal Title
  
  bioRxiv
  
  Volume: 10.1101/2021.02.02.428362
- DOI
  10.1101/2021.02.02.428362
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378, KAKENHI-PROJECT-23K21400
[Journal Article] Protein lactylation induced by neural excitation2021
- Author(s)
  Hagihara Hideo、Shoji Hirotaka、Otabi Hikari、Toyoda Atsushi、Katoh Kaoru、Namihira Masakazu、Miyakawa Tsuyoshi
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 2 Pages: 109820-109820
- DOI
  10.1016/j.celrep.2021.109820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06462, KAKENHI-PROJECT-18K07378, KAKENHI-PROJECT-19K06502, KAKENHI-PROJECT-20H00522, KAKENHI-PLANNED-17H06417
[Journal Article] Protein lactylation induced by neural excitation2021
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Kaoru Katoh, Masakazu Namihira, Tsuyoshi Miyakawa
- Journal Title
  
  bioRxiv
  
  Volume: 10.1101/2021.02.02.428370 Pages: 428362-428362
- DOI
  10.1101/2021.02.02.428370
- Open Access
- Data Source
  KAKENHI-PROJECT-18K07378, KAKENHI-PROJECT-19K06502
[Journal Article] Decreased brain pH as a shared endophenotype of psychiatric disorders.2018
- Author(s)
  Hagihara H et al.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 43 Issue: 3 Pages: 459-468
- DOI
  10.1038/npp.2017.167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01413, KAKENHI-PLANNED-16H06462, KAKENHI-PROJECT-25242078, KAKENHI-PROJECT-15K18379, KAKENHI-PROJECT-16H06276
[Journal Article] Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism.2017
- Author(s)
  Murano T, Koshimizu H, Hagihara H, *Miyakawa T.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 44531-44531
- DOI
  10.1038/srep44531
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078, KAKENHI-PLANNED-16H06462
[Journal Article] Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability.2017
- Author(s)
  Nakao A et al.
- Journal Title
  
  Mol. Brain
  
  Volume: 10 Issue: 1 Pages: 60-67
- DOI
  10.1186/s13041-017-0339-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01413, KAKENHI-PLANNED-16H06462, KAKENHI-PROJECT-25242078, KAKENHI-PROJECT-15K18379, KAKENHI-PROJECT-16H06280
[Journal Article] Circadian gene circuitry predicts hyperactive behavior in a mood disorder mouse model.2016
- Author(s)
  Hagihara H, Horikawa T, Nakamura HK, Umemori J, Shoji H, Kamitani Y, Miyakawa T.
- Journal Title
  
  Cell Reports,
  
  Volume: 14(12) Issue: 12 Pages: 2784-96
- DOI
  10.1016/j.celrep.2016.02.067
- NAID
  120005829372
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01297, KAKENHI-PROJECT-25242078
[Journal Article] Immaturity of brain as an endophenotype of neuropsychiatric disorders2016
- Author(s)
  Hagihara H, Shoji H, Miyakawa T.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 148 Issue: 4 Pages: 168-175
- DOI
  10.1254/fpj.148.168
- NAID
  130005598203
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06462, KAKENHI-PROJECT-25242078
[Journal Article] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia.2014
- Author(s)
  Hagihara H, Ohira K, Takao K, Miyakawa T.
- Journal Title
  
  Mol Brain
  
  Volume: 7 Issue: 1 Pages: 41-41
- DOI
  10.1186/1756-6606-7-41
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25350989, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-25242078
[Journal Article] Reply to Davis et al. and Shay et al.: Commonalities across species do exist and are potentially important2014
- Author(s)
  Takao K, Hagihara H, Miyakawa T
- Journal Title
  
  Proceedings of the National Academy of Sciences USA
  
  Volume: 112 Issue: 4 Pages: 347-348
- DOI
  10.1073/pnas.1417369111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25350989, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-25242078
[Journal Article] In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI)2013
- Author(s)
  Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T.
- Journal Title
  
  Frontiers in Integrative Neuroscience
  
  Volume: 40 Pages: 125-132
- DOI
  10.3389/fnint.2013.00076
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24300167, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence of hyper-maturation in the mouse hippocampus induced by genetic and other factors2022
- Author(s)
  萩原英雄、小清水久嗣、服部聡子、田中美歩、池田和隆、宮川剛
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Transcriptomic evidence of hyper-maturation in the mouse hippocampus induced by genetic and other factors2022
- Author(s)
  萩原英雄、小清水久嗣、服部聡子、田中美歩、池田和隆、宮川剛
- Organizer
  BPCNPNPPP4学会合同年会
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Inhibition of brain lactate response to social defeat stress causes persistent exacerbation of anxiety-like behaviors and paradoxical increase of brain lactate levels2021
- Author(s)
  Hideo Hagihara, Yoshihiro Takamiya, Hirotaka Shoji, Tsuyoshi Miyakawa
- Organizer
  32nd CINP World Congress of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Systematic analysis of brain lactate and pH levels in 73 animal models related to neuropsychiatric conditions2021
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, International Brain pH Project Consortium, Tsuyoshi Miyakawa
- Organizer
  60th Annual Meeting of the American College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Protein lactylation induced by neural excitation2021
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Kaoru Katoh, Masakazu Namihira, Tsuyoshi Miyakawa
- Organizer
  60th Annual Meeting of the American College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19314
[Presentation] Protein lactylation induced by neural excitation2021
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Kaoru Katoh, Masakazu Namihira, Tsuyoshi Miyakawa
- Organizer
  60th Annual Meeting of the American College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] 慢性社会的挫折ストレスモデルマウスにおける乳酸産生阻害剤による不安様行動の悪化と脳内乳酸量の逆説的増加2020
- Author(s)
  萩原英雄, 昌子浩孝, 高宮義博, 宮川剛
- Organizer
  "第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第４回日本精神薬学会総会・学術集会（NPBPPP2020）合同年会"
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Endogenous brain lactate response to social defeat stress to reduce anxiety in mice2020
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Yoshihiro Takamiya, Tsuyoshi Miyakawa
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Anxiety-like behaviors are enhanced by lactate dehydrogenase inhibitor in a mouse model of chronic social defeat stress2019
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Yoshihiro Takamiya, Tsuyoshi Miyakawa
- Organizer
  49th Annual Meeting of Japanese Society of Neuropharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Decreased brain pH as a shared endophenotype of psychiatric disorders2019
- Author(s)
  Hideo Hagihara, Tsuyoshi Miyakawa
- Organizer
  6th Congress of Asian College of Neuropsychopharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Enhanced anxiety-like behaviors by lactate dehydrogenase inhibitor treatment in a mouse model of chronic social defeat stress2019
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Yoshihiro Takamiya, Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Decreased brain pH in patients with depression and in a social defeat mouse model2018
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Tsuyoshi Miyakawa
- Organizer
  総医研研究成果発表会
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Decreased brain pH in patients with depression and in a social defeat mouse model2018
- Author(s)
  Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Tsuyoshi Miyakawa
- Organizer
  The International College of Neuropsychopharmacology World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07378
[Presentation] Lower brain pH as a shared endophenotype of psychiatric disorders2017
- Author(s)
  Hideo Hagihara, Vibeke S Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L Huang, Kuo-Ping Huang, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Keiichi I Nakayama, Cynthia Shannon Weicker, Tsuyoshi Miyakawa
- Organizer
  Society for Neuroscience 47th Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Neurogranin deficiency causes behavioral and molecular phenotypes related to schizophrenia in mice2017
- Author(s)
  Satoko Hattori, Hideo Hagihara, Yoshihiro Takamiya, Toshiki Kameyama, Yuya Ouchi, Hidehito Inagaki, Hiroki Kurahashi, Freesia L Huang, Kuo-Ping Huang, Tsuyoshi Miyakawa
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Lower Brain pH as a Shared Endophenotype of Psychiatric Disorders2017
- Author(s)
  Hideo Hagihara, Vibeke Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L Huang, Kuo-Ping Huang, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Keiichi I Nakayama, Cynthia Shannon Weickert, Tsuyoshi Miyakawa
- Organizer
  5th Congress of Asian College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Lower brain pH as a shared endophenotype of psychotic disorders2017
- Author(s)
  Hideo Hagihara, Vibeke Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L Huang, Kuo-Ping Huang, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Keiichi I Nakayama, Cynthia Shannon Weickert, Tsuyoshi Miyakawa
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] 脳内中間表現型：遺伝子と行動をつなぐためのキーコンセプト2017
- Author(s)
  萩原英雄
- Organizer
  医療心理懇話会　第2回集会
- Invited
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Immature morphological properties in subcellular-scale structures in dentate gyrus of Schnurri-2 knockout mice, an animal model for schizophrenia and intellectual disability2017
- Author(s)
  Akito Nakao, Naoyuki Miyazaki, Koji Ohira, Hideo Hagihara, Tsuyoshi Takagi, Shunsuke Ishii, Nobuteru Usuda, Kazuyoshi Murata, Tsuyoshi Miyakawa
- Organizer
  第49回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] 脳内のエンドフェノタイプ: 遺伝子と行動の関係性を理解するためのキーコンセプト2017
- Author(s)
  萩原英雄、宮川剛
- Organizer
  ConBio2017 (2017年度生命科学系学会合同年次大会) 日本分子生物学会、日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns of inflammation-related genes in mouse models of depression and psychosis.2016
- Author(s)
  小清水久嗣, 萩原英雄, 宮川剛
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic immaturity of hippocampus and prefrontal cortex in patients with alcoholism.2016
- Author(s)
  Murano T., Hagihara H., Miyakawa T.
- Organizer
  30th CINP（The International College of Neuropsychopharmacology） World Congress of Neuropsychopharmacology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns of inflammation-related genes in mouse models of depression and psychosis2016
- Author(s)
  Koshimizu H., Hagihara H., Miyakawa T.
- Organizer
  15th Annual Molecular and Cellular Cognition Society Meeting
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence for dematuration of the mouse frontal cortex and hippocampus by chronic antidepressant treatment.2016
- Author(s)
  萩原英雄, 大平耕司, 宮川剛
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic immaturity of hippocampus and prefrontal cortex in patients with alcoholism.2016
- Author(s)
  Murano T., Hagihara H., Miyakawa T.
- Organizer
  (JSNP) 第46回日本神経精神薬理学会年会
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns of inflammation-related genes in mouse models of depression and psychosis.2016
- Author(s)
  Koshimizu H., Hagihara H., Miyakawa T.
- Organizer
  46th Annual meeting of Society for Neuroscience
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Deficiency of neurogranin, a susceptible gene for schizophrenia, causes behavioral phenotypes related to schizophrenia and immaturity of the dentate gyrus in mice.2016
- Author(s)
  Hattori S., Hagihara H., Takamiya Y., Kameyama T., Ouchi Y., Inagaki H., Kurahashi H., Huang F.L., Huang K.P., Miyakawa T.
- Organizer
  (JSNP) 第46回日本神経精神薬理学会年会
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Repeated restraint stress induces alteration in maturation makers of dentate gyrus neurons in BALB/c mice.2016
- Author(s)
  Shoji H, Hagihara H, Miyakawa T.
- Organizer
  30th CINP（The International College of Neuropsychopharmacology） World Congress of Neuropsychopharmacology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] CDKL5 controls postsynaptic NMDA receptor localization and regulates memory, emotion and seizure susceptibility.2016
- Author(s)
  村上拓冬, 奥田耕助, 小林静香, 深谷昌弘, 高雄啓三, 渡邉紀, 萩原舞, 阪上洋行, 水口雅, 宮川剛, 真鍋俊也, 田中輝幸
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Deficiency of neurogranin, a susceptible gene for schizophrenia, causes behavioral phenotypes related to schizophrenia and immaturity of the dentate gyrus in mice.2016
- Author(s)
  Hattori S., Hagihara H., Takamiya Y., Kameyama T., Ouchi Y., Inagaki H., Kurahashi H., Huang F.L., Huang K.P., Miyakawa T.
- Organizer
  30th CINP（The International College of Neuropsychopharmacology） World Congress of Neuropsychopharmacology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Genomic responses in mouse models greatly mimic human inflammatory / psychiatric diseases.2016
- Author(s)
  Miyakawa T., Takao K., Hagihara H.
- Organizer
  2016 IBANCS (International Behavioral and Neural Genetics Society) Meeting
- Place of Presentation
  Bar Harbor Maine, USA
- Year and Date
  2016-05-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns of inflammation-related genes in mouse models of depression and psychosis.2016
- Author(s)
  Koshimizu H., Hagihara H., Miyakawa T.
- Organizer
  (JSNP) 第46回日本神経精神薬理学会年会
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Lower Brain pH as a Shared Endophenotype of Psychiatric Disorders2016
- Author(s)
  Hagihara H., Catts V., Katayama Y., Takagi T., Huang F.L., Huang LP., Ishii S., Graef I.A., Crabtree G.R., Nakayama K.I., Weickert C.S., Miyakawa T.*
- Organizer
  55th Annual Meeting of American College of Neuropsychoparmacology (ACNP)
- Place of Presentation
  Hollywood, Florida, USA
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Repeated restraint stress causes alteration in neuronal maturation makers in the dentate gyrus in BALB/c mice.2016
- Author(s)
  Shoji H, Hagihara H, Miyakawa T.
- Organizer
  46th Annual meeting of Society for Neuroscience
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Repeated restraint stress-induced alterations in maturation makers of dentate gyrus neurons in BALB/c mice.2016
- Author(s)
  Shoji H, Hagihara H, Miyakawa T.
- Organizer
  (JSNP) 第46回日本神経精神薬理学会年会
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns of inflammation-related genes in mouse models of depression and psychosis.2016
- Author(s)
  Koshimizu H., Hagihara H., Miyakawa T.
- Organizer
  30th CINP（The International College of Neuropsychopharmacology） World Congress of Neuropsychopharmacology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Neurogranin-deficient mice reveal schizophrenia-related behaviors and immaturity of the dentate gyrus2015
- Author(s)
  Satoko Hattori, Hideo Hagihara, Hirotaka Shoji, Yoshihiro Takamiya, Freesia L Huang , Kuo-Ping Huang, Tsuyoshi Miyakawa
- Organizer
  Society for Neuroscience 2015 Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Neurogranin deficiency causes neuronal immaturity in the dentate gyrus and frontal cortex of adult mice2015
- Author(s)
  Hideo Hagihara, Satoko Hattori, Yoshihiro Takamiya, Freesia L Huang, Kuo-Ping Huang, Tsuyoshi Miyakawa
- Organizer
  Society for Neuroscience 2015 Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic “hyper-maturity” of the hippocampal dentate gyrus in mice2015
- Author(s)
  Hisatsugu Koshimizu, Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Alterations in diurnal expression patterns of circadian genes in the dentate gyrus of mice showing exaggerated infradian rhythm2015
- Author(s)
  Hideo Hagihara, Tsuyoshi Miyakawa
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Neurogranin deficiency causes schizophrenia-related behaviors and immaturityof the dentate gyrus in mice2015
- Author(s)
  Satoko Hattori, Hideo Hagihara, Hirotaka Shoji, Yoshihiro Takamiya, Freesia L. Huang, Kuo-Ping Huang, Tsuyoshi Miyakawa
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression pattern for immaturity and maturity marker genes in the dentate gyrus between mouse lines with “immature dentate gyrus” and mice overexpressing glucocorticoid receptor2014
- Author(s)
  Hisatsugu Koshimizu, Hideo Hagihara, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia2014
- Author(s)
  Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  29th CINP World Congress of Neuropsychopharmacology
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia2014
- Author(s)
  Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  Molecular and Cellular Cognition Society
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] ranscriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia2014
- Author(s)
  Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence for the immaturity in the frontal cortex of mice treated with antidepressants2014
- Author(s)
  Koji Ohira, Hideo Hagihara, Rika Takeuchi, Tsuyoshi Miyakawa
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns for immaturity and maturity marker genes in the dentate gyrus between mouse line with ‘immature dentate gyrus’ and mice overexpressing glucocorticoid receptor2014
- Author(s)
  Hisatsugu Koshimizu, Hideo Hagihara, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  Molecular and Cellular Cognition Society
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence for immaturity in the frontal cortex and dentate gyrus of mice treated with antidepressants2014
- Author(s)
  Koji Ohira, Hideo Hagihara, Rika Takeuchi, Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Retrospective prediction of behavioral state by hippocampal transcriptomes2014
- Author(s)
  Hideo Hagihara, Tomoyasu Horikawa, Hironori K. Nakamura, Hirotaka Shoji, Yukiyasu Kamitani, Tsuyoshi Miyakawa
- Organizer
  29th CINP World Congress of Neuropsychopharmacology
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia2014
- Author(s)
  Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Contrasting expression patterns for immaturity and maturity marker genes in the dentate gyrus between mouse line with ‘immature dentate gyrus’ and mice overexpressing glucocorticoid receptor2014
- Author(s)
  Hisatsugu Koshimizu, Hideo Hagihara, Keizo Takao, Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Dysregulation of BDNF-MAPK signaling pathway in the hippocampus of mice with “immature dentate gyrus.
- Author(s)
  Hisatsugu Koshimizu, Koji Ohira, Hideo Hagihara, Keizo Takao, Tsuyoshi Takagi, Masakazu Kataoka, Shunsuke Ishii, Masami Takahashi, Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego , USA
- Year and Date
  2013-11-09 – 2013-11-13
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Decreased parvalbumin immunoreactivity and altered perineuronal net labeling in the frontal cortex of schizophrenia model mice
- Author(s)
  Hideo Hagihara, Tsuyoshi Takagi, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, and Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego , USA
- Year and Date
  2013-11-09 – 2013-11-13
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] “Immature dentate gyrus”, a candidate endophenotype for psychotic disorders, emerges after adolescence in Schnurri-2 KO mice.
- Author(s)
  Keizo Takao, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego , USA
- Year and Date
  2013-11-09 – 2013-11-13
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Dysregulation of BDNF-MAPK signaling pathway in the hippocampus of mice with “immature dentate gyrus”
- Author(s)
  Hisatsugu Koshimizu, Koji Ohira, Hideo Hagihara, Keizo Takao, Tsuyoshi Takagi, Masakazu Kataoka, Shunsuke Ishii, Masami Takahashi, Tsuyoshi Miyakawa
- Organizer
  12th Annual Molecular and Cellular Congnition Society Meeting
- Place of Presentation
  San Diego , USA
- Year and Date
  2013-11-07 – 2013-11-08
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] Decreased parvalbumin immunoreactivity and altered perineuronal net labeling in the frontal cortex of schizophrenia model mice
- Author(s)
  Hideo Hagihara, Tsuyoshi Takagi, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Tsuyoshi Miyakawa
- Organizer
  12th Annual Molecular and Cellular Congnition Society Meeting
- Place of Presentation
  San Diego , USA
- Year and Date
  2013-11-07 – 2013-11-08
- Data Source
  KAKENHI-PROJECT-25242078
[Presentation] “Immature dentate gyrus”, a candidate endophenotype for psychotic disorders, emerges after adolescence in Schnurri-2 KO mice.
- Author(s)
  Keizo Takao, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa
- Organizer
  12th Annual Molecular and Cellular Congnition Society Meeting
- Place of Presentation
  San Diego , USA
- Year and Date
  2013-11-07 – 2013-11-08
- Data Source
  KAKENHI-PROJECT-25242078

1. TAKAO Keizo (80420397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. SHOJI Hirotaka (00466278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Miyakawa Tsuyoshi (10301780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 49 results
4. Ohira Koji (80402832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. Koshimizu Hisatsugu (10610842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. UMEMORI Juzoh (20462913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 須原哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hagihara Hideo 萩原 英雄

HAGIHARA Hideo 萩原 英雄

Research Projects

Research Products

Co-Researchers

アストロサイトの炎症応答におけるタンパク質乳酸修飾の機能推定Principal Investigator

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Protein lactylation in the brains of animal models of neuropsychiatric disordersPrincipal Investigator

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Brain pH in animal models of neuropsychiatric disordersPrincipal Investigator

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Maturation abnormalities of astrocytes in the brain of mouse model of psychiatric disordersPrincipal Investigator

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Time-course analysis of gene expression patterns in the brain of a mouse model of schizophrenia during postnatal developmentPrincipal Investigator

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Exploring the relationship between altered neuronal maturation state in the hippocampal dentate gyrus and behavior

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Elucidation and regulation of bi-directional changes in neuronal maturation status

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[Journal Article] Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment2024

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[Journal Article] Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions2021

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[Journal Article] Protein lactylation induced by neural excitation2021

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[Journal Article] Protein lactylation induced by neural excitation2021

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[Journal Article] Decreased brain pH as a shared endophenotype of psychiatric disorders.2018

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[Journal Article] Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism.2017

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[Journal Article] Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability.2017

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Hagihara Hideo 萩原英雄

HAGIHARA Hideo 萩原英雄