Sekiya Takashi 関谷高史

… Alternative Names

SEKIYA Takashi 関谷高史

関谷高史セキヤタカシ

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Researcher Number	80519207
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所肝炎・免疫研究センター, 室長
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立研究開発法人国立国際医療研究センター, その他部局等, 免疫応答修飾研究室長 2017: 国立研究開発法人国立国際医療研究センター, その他部局等, 肝炎・免疫研究センター免疫制御部免疫応答修飾研究室長 2017: 慶應義塾大学, 医学部, 講師 2016: 国立研究開発法人国立国際医療研究センター, その他部局等, 室長 2014 – 2015: 慶應義塾大学, 医学部, 講師 2011 – 2012: 慶應義塾大学, 医学部, 助教 2009: 慶應大, 医学部, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49070:Immunology-related / General medical chemistry / Complex systems / Biological Sciences / Complex Systems Disease Theory / Immunology Except Principal Investigator Immunology
Keywords	Principal Investigator 免疫学 / CD4T細胞 / 制御性T細胞 / 自己免疫疾患 / 細胞リプログラミング / 生体イメージング / T細胞 / エピジェネティクス / 免疫寛容 / IL-1b … More / ナイーブT細胞 / 腫瘍免疫 / ゲノム編集 / 癌免疫 / 抗腫瘍免疫 / 炎症性腸疾患 / in vivoイメージング / ネオセルフ / ネオ抗原 / 実験的自己免疫性脳脊髄炎 / 免疫 / アレルギー・ぜんそく / レポーターシステム / in vivoレポーター / 炎症性疾患 / アレルギー / 細胞分化 … More Except Principal Investigator チロシンキナーゼ / インフラマゾーム / 自然免疫 / 細菌 / 生体恒常性 / T細胞 / 組織傷害 / TGFβ / アレルギー・ぜんそく / 免疫学 / レチノイン酸受容体 / 転写因子 / スカベンジャー受容体 / 修復機構 / 組織損傷 / 脳梗塞 / 修復 / 組織障害 / 制御性T細胞 / マクロファージ / 炎症 / シグナル伝達 / サイトカイン Less

ナイーブT細胞の不均一性に着目した組織特異的免疫応答の解明および免疫制御法の開発Principal Investigator
- Principal Investigator
  
  関谷高史
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  National Center for Global Health and Medicine
Reprogramming of exhausted CTL by targeting enhancers with multi-dimensional regulatory activitiesPrincipal Investigator
- Principal Investigator
  
  Sekiya Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  National Center for Global Health and Medicine
Mechanisms and meanings of phenotypic alteration of naive CD4 T cellsPrincipal Investigator
- Principal Investigator
  
  Sekiya Takashi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  National Center for Global Health and Medicine
IBD発症過程で生じるTh/Treg imbalanceの動態解析Principal Investigator
- Principal Investigator
  
  関谷高史
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Center for Global Health and Medicine
CD4T細胞による「セルフ」の攻撃に作用する「ネオセルフ」抗原刺激の追求Principal Investigator
- Principal Investigator
  
  関谷高史
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center for Global Health and Medicine
Development of the novel screening method for reprogramming of inflammatory environmentPrincipal Investigator
- Principal Investigator
  
  Sekiya Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  National Center for Global Health and Medicine
Analysis of autoimmune diseases pathogenesis with a novel reporter systemPrincipal Investigator
- Principal Investigator
  
  Sekiya Takashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  National Center for Global Health and Medicine
Molecular mechanisms for CD4 T cell differentiation, aiming at generation of functional Treg cellsPrincipal Investigator
- Principal Investigator
  
  Sekiya Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  National Center for Global Health and Medicine
  Keio University
Identification of Cellular Signaling Mechanism that regulates inflammation and tissue repairing
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Analysis of the molecular mechanisms which underlies the dynamiccharacteristics of regulatory T cell functionPrincipal Investigator
- Principal Investigator
  
  SEKIYA Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Keio University
エピジェネティック解析による制御性T細胞分化メカニズムの解明および異分化誘導Principal Investigator
- Principal Investigator
  
  関谷高史
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] Nr4aによるTh/Tregのバランス制御と炎症性疾患2021
- Author(s)
  関谷　高史
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-21K19393
[Book] Nr4aによるTh/Tregのバランス制御と炎症性疾患2021
- Author(s)
  関谷　高史
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PUBLICLY-20H04958
[Book] Nr4aによるTh/Tregのバランス制御と炎症性疾患2021
- Author(s)
  関谷　高史
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PUBLICLY-19H04822
[Book] Nr4aによるTh/Tregのバランス制御と炎症性疾患2021
- Author(s)
  関谷　高史
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-21H02756
[Book] T細胞疲弊を制御するマスター転写因子2020
- Author(s)
  関谷　高史
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PUBLICLY-19H04822
[Book] 臨床免疫・アレルギー科2020
- Author(s)
  関谷　高史
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-18H02673
[Book] 医学のあゆみ制御性T細胞研究の現在2019
- Author(s)
  関谷　高史
- Total Pages
  6
- Publisher
  医歯薬出版
- ISBN
- Data Source
  KAKENHI-PROJECT-16KT0114
[Book] 医学のあゆみ　制御性T細胞研究の現在2019
- Author(s)
  関谷　高史
- Total Pages
  6
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16KT0114
[Book] 医学のあゆみ　制御性T細胞研究の現在2019
- Author(s)
  関谷　高史
- Total Pages
  6
- Publisher
  医歯薬出版
- ISBN
- Data Source
  KAKENHI-PROJECT-18H02673
[Book] 医学のあゆみ　制御性T細胞研究の現在2019
- Author(s)
  関谷　高史
- Total Pages
  6
- Publisher
  医歯薬出版
- ISBN
- Data Source
  KAKENHI-PUBLICLY-19H04822
[Book] Epigenetics of Autoimmunity2018
- Author(s)
  Takashi Sekiya
- Total Pages
  432
- Publisher
  Elsevir
- ISBN
  9780128099285
- Data Source
  KAKENHI-PROJECT-16KT0114
[Book] 臨床免疫・アレルギー2012
- Author(s)
  関谷　高史
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23790346
[Book] Nr4a2によるFoxp3の誘導機構臨床免疫・アレルギー、57 巻2012
- Author(s)
  関谷高史, 吉村昭彦
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23790346
[Journal Article] Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T?cells2024
- Author(s)
  Sekiya Takashi、Hidano Shinya、Takaki Satoshi
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 3 Pages: 113954-113954
- DOI
  10.1016/j.celrep.2024.113954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17417, KAKENHI-PROJECT-21H02756
[Journal Article] Estimation of Sensitization Status in Renal Transplant Recipients by Assessing Indirect Pathway CD4+ T Cell Response to Donor Cell-pulsed Dendritic Cell2023
- Author(s)
  Kenta Iwasaki、Toshihide Tomosugi、Takashi Sekiya、Shintaro Sakamoto、Yuko Miwa、Manabu Okada、Takahisa Hiramitsu、Norihiko Goto、Shunji Narumi、Yoshihiko Watarai、Mai Okumura、Satoshi Ashimine、Kohei Ishiyama、Ezzelarab Mohamed B.、Takaaki Kobayashi
- Journal Title
  
  Transplantation
  
  Volume: 107 Issue: 5 Pages: 1079-1088
- DOI
  10.1097/tp.0000000000004491
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03818, KAKENHI-PROJECT-21H02756, KAKENHI-PROJECT-20K20608, KAKENHI-PROJECT-21K19393, KAKENHI-PROJECT-21K09385
[Journal Article] Essential roles of the transcription factor NR4A1 in regulatory T cell differentiation under the influence of immunosuppressants2022
- Author(s)
  Takashi Sekiya, Hidenori Kasahara, Ryo Takemura, Shinya Fujita, Jun Kato, Noriko Doki, Yuta Katayama, Yukiyasu Ozawa, Satoru Takada, Tetsuya Eto, Takahiro Fukuda, Tatsuo Ichinohe, Minoko Takanashi, Makoto Onizuka, Yoshiko Atsuta, Shinichiro Okamoto, Akihiko Yoshimura, Satoshi Takaki, Takehiko Mori
- Journal Title
  
  The Journal of Immunology
  
  Volume: in press Issue: 9 Pages: 2122-2130
- DOI
  10.4049/jimmunol.2100808
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04822, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04958, KAKENHI-PROJECT-21H02756, KAKENHI-PROJECT-21K19393, KAKENHI-PROJECT-22K19444, KAKENHI-PROJECT-21H05044
[Journal Article] Comparison between Nr4a transcription factor regulation and function in lymphoid and tumor Treg cells2022
- Author(s)
  Takashi Sekiya
- Journal Title
  
  Frontiers in Immunology
  
  Volume: in press Pages: 866339-866339
- DOI
  10.3389/fimmu.2022.866339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04822, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04958, KAKENHI-PROJECT-21H02756, KAKENHI-PROJECT-21K19393
[Journal Article] Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors.2021
- Author(s)
  Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki .
- Journal Title
  
  iScience.
  
  Volume: 24 Issue: 3 Pages: 102166-102166
- DOI
  10.1016/j.isci.2021.102166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-20K20384, KAKENHI-PUBLICLY-19H04822
[Journal Article] RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-42019
- Author(s)
  Sekiya Takashi, Takaki Satoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 6984-6984
- DOI
  10.1038/s41598-019-43068-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04822, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-16KT0114
[Journal Article] miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity2019
- Author(s)
  Lyszkiewicz Marcin, Takashi Sekiya, Andreas Krueger et al.
- Journal Title
  
  PLOS Biology
  
  Volume: 17 Issue: 3 Pages: e2006716-e2006716
- DOI
  10.1371/journal.pbio.2006716
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04822, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-16KT0114
[Journal Article] NR4A transcription factors limit CAR T cell function in solid tumours2019
- Author(s)
  Chen Joyce、L?pez-Moyado Isaac F.、Seo Hyungseok、Lio Chan-Wang J.、Hempleman Laura J.、Sekiya Takashi、Yoshimura Akihiko、Scott-Browne James P.、Rao Anjana
- Journal Title
  
  Nature
  
  Volume: 567 Issue: 7749 Pages: 530-534
- DOI
  10.1038/s41586-019-0985-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-17H06175, KAKENHI-PUBLICLY-19H04822, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16KT0114
[Journal Article] Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells2018
- Author(s)
  Takashi Sekiya、Hibino Sana、Saeki Keita、Kanamori Mitsuhiro、Takaki Satoshi、Yoshimura Akihiko
- Journal Title
  
  Cell Reports
  
  Volume: 24 Issue: 6 Pages: 1627-1638.e6
- DOI
  10.1016/j.celrep.2018.07.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384
[Journal Article] Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy2017
- Author(s)
  Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, Hiroko Nakatsukasa, Takashi Sekiya, Shunsuke Chikuma, Takashi Shichita, Mitsuhiro Kanamori, Masato Kubo, Keiko Koga, Takahiro Miyazaki, Yoshiaki Kassai, Akihiko Yohimura
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15338-15338
- DOI
  10.1038/ncomms15338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-16H05178, KAKENHI-PROJECT-17H07088
[Journal Article] Generation of alloantigen-specific induced-Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model2017
- Author(s)
  Hidenori Kasahara, Taisuke Kondo, Hiroko Nakatsukasa, Shunsuke Chikuma, Minako Ito, Makoto Ando, Yutaka Kurebayashi, Takashi Sekiya, Taketo Yamada, Shinichiro Okamoto, Akihiko Yoshimura
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 10 Pages: 457-469
- DOI
  10.1093/intimm/dxx060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-16J07143
[Journal Article] Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells.2016
- Author(s)
  Sekiya T, Nakatsukasa H, Lu Q, and Yoshimura A.
- Journal Title
  
  Microbes Infect.
  
  Volume: 18 Issue: 6 Pages: 378-386
- DOI
  10.1016/j.micinf.2016.02.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-15K19135, KAKENHI-PROJECT-16KT0114
[Journal Article] Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells2015
- Author(s)
  Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A
- Journal Title
  
  J Exp Med.
  
  Volume: 212 Issue: 10 Pages: 1623-1640
- DOI
  10.1084/jem.20142088
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PUBLICLY-15H01422, KAKENHI-PROJECT-14J07006, KAKENHI-PROJECT-26670470, KAKENHI-PROJECT-26870571, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305
[Journal Article] ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.2015
- Author(s)
  Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 112 Issue: 1 Pages: 160-165
- DOI
  10.1073/pnas.1413234112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-26461137, KAKENHI-PROJECT-26670470
[Journal Article] Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22.2015
- Author(s)
  Sakaguchi R, Chikuma S, Shichita T, Morita R, Sekiya T, Ouyang W, Ueda T, Seki H, Morisaki H, Yoshimura A
- Journal Title
  
  Int Immunol.
  
  Volume: 28 Issue: 5 Pages: 233-243
- DOI
  10.1093/intimm/dxv070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-13J01369, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16H05178
[Journal Article] Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production2014
- Author(s)
  Kimura A, Abe H, Tsuruta S, Chiba S, Fujii-Kuriyama Y, Sekiya T, Morita R, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: 26 Issue: 4 Pages: 209-220
- DOI
  10.1093/intimm/dxt067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24117718, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-25860324, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305
[Journal Article] Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.2014
- Author(s)
  Takasato F, Morita R, Schichita T, Sekiya T, Morikawa Y, Kuroda T, Niimi M, Yoshimura A.
- Journal Title
  
  PLoS One.
  
  Volume: 9(2) Issue: 2 Pages: e87722-e87722
- DOI
  10.1371/journal.pone.0087722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-25221305
[Journal Article] Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-Y expression and inducing IL-222014
- Author(s)
  Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, et al.
- Journal Title
  
  Int Immunol.
  
  Volume: 26 Issue: 3 Pages: 129-137
- DOI
  10.1093/intimm/dxt049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J08459, KAKENHI-PUBLICLY-24117718, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-25221305
[Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.2013
- Author(s)
  Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
- Journal Title
  
  Nat Immunol.
  
  Volume: 14 Issue: 3 Pages: 230-237
- DOI
  10.1038/ni.2520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08459, KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23659242, KAKENHI-PROJECT-23790346, KAKENHI-PROJECT-23790545, KAKENHI-PROJECT-25670233
[Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells2011
- Author(s)
  Sekiya, T., et al
- Journal Title
  
  Nature Communications
  
  Volume: 2 Issue: 1 Pages: 269-269
- DOI
  10.1038/ncomms1272
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059014, KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23790346, KAKENHI-PROJECT-23390123
[Presentation] 免疫抑制剤存在下でのTreg分化における転写因子NR4A1の役割2023
- Author(s)
  関谷　高史
- Organizer
  第20回日本免疫治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02756
[Presentation] 免疫抑制剤存在下でのTreg分化における転写因子NR4A1の役割2023
- Author(s)
  関谷　高史
- Organizer
  第20回日本免疫治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K17417
[Presentation] Tonic TCR and IL-1b signaling mediate momentary and durable phenotypic alterations in naive CD4+ T cells2022
- Author(s)
  関谷　高史
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02756
[Presentation] Tonic TCR and IL-1b signaling mediate momentary and durable phenotypic alterations in naive CD4+ T cells2022
- Author(s)
  関谷　高史
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19393
[Presentation] Roles of the nuclear orphan receptor Nr4a in Th/Treg differentiation and in regulation of allergic asthma pathogenesis2019
- Author(s)
  Takashi Sekiya, Satoshi Takaki, and Akihiko Yoshimura
- Organizer
  The 17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04822
[Presentation] 制御性T細胞移入療法の進歩を導く基礎研究の現在2019
- Author(s)
  関谷　高史
- Organizer
  第55回日本移植学会総会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04822
[Presentation] 制御性T細胞移入療法の進歩を導く基礎研究の現在2019
- Author(s)
  関谷　高史
- Organizer
  第55回日本移植学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02673
[Presentation] 制御性T細胞移入療法の進歩を導く基礎研究の現在2019
- Author(s)
  関谷　高史
- Organizer
  第55回日本移植学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0114
[Presentation] Roles of the nuclear orphan receptor Nr4a in Th/Treg differentiation and in regulation of allergic asthma pathogenesis2019
- Author(s)
  Takashi Sekiya, Satoshi Takaki, and Akihiko Yoshimura
- Organizer
  The 17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114
[Presentation] Nr4aファミリー転写因子によるCD4T細胞の分化制御2019
- Author(s)
  関谷　高史
- Organizer
  第28回　東京免疫フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02673
[Presentation] Nr4aファミリー転写因子によるCD4T細胞の分化制御2019
- Author(s)
  関谷　高史
- Organizer
  第28回　東京免疫フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0114
[Presentation] Roles of the nuclear orphan receptor Nr4a in Th/Treg differentiation and in regulation of allergic asthma pathogenesis2019
- Author(s)
  Takashi Sekiya, Satoshi Takaki, and Akihiko Yoshimura
- Organizer
  The 17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02673
[Presentation] Roles of the nuclear orphan receptor Nr4a in Th/Treg differentiation and in regulation of allergic asthma pathogenesis2018
- Author(s)
  Takashi Sekiya, Satoshi Takaki, and Akihiko Yoshimura
- Organizer
  日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02673
[Presentation] Roles of the nuclear orphan receptor Nr4a in Th/Treg differentiation and in regulation of allergic asthma pathogenesis2018
- Author(s)
  Takashi Sekiya, Satoshi Takaki, and Akihiko Yoshimura
- Organizer
  日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16KT0114
[Presentation] Nr4a receptors promote completion of Treg cell developmental program and prevent conversion of labile Treg precursors into pathogenic cells2016
- Author(s)
  Takashi Sekiya and Akihiko Yoshimura
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114
[Presentation] Nr4a receptors promote completion of Treg cell developmental program and prevent conversion of labile Treg precursors into pathogenic cells2016
- Author(s)
  Takashi Sekiya and Akihiko Yoshimura
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713019
[Presentation] Regulation of CD4 T cell differentiationand inflammatory diseases by the nuclearorphan receptor Nr4a22012
- Author(s)
  関谷高史、吉村昭彦
- Organizer
  第41回日本免疫学会学術集会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790346
[Presentation] Roles of the nuclear orphan receptor Nr4a2 in regulation of CD4 T cell differentiation and inflammatory diseases2012
- Author(s)
  Takashi Sekiya, Akihiko Yoshimura
- Organizer
  Keystone symposia
- Place of Presentation
  Keystone resort (Colorado, USA)
- Data Source
  KAKENHI-PROJECT-23790346
[Presentation] Regulation of CD4 T cell differentiation and inflammatory diseases by the nuclear orphan receptor Nr4a22012
- Author(s)
  関谷　高史
- Organizer
  第41回日本免疫学会学術集会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790346
[Presentation] Roles of the nuclear orphan receptor Nr4a2in regulation of CD4+ T celldifferentiation and inflammatorydiseases2012
- Author(s)
  Takashi Sekiya and Akihiko Yoshimura
- Organizer
  Keystone Symposia: The Biology of Cytokines
- Place of Presentation
  Colorado (USA)
- Data Source
  KAKENHI-PROJECT-23790346
[Presentation] 核内オーファン受容体Nr4a2によるCD4T細胞分化と自己免疫疾患の制御2011
- Author(s)
  関谷高史、吉村昭彦
- Organizer
  第40回日本免疫学会学術集会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23790346
[Presentation] 核内オーファン受容体Nr4a2によるCD4T細胞分化と自己免疫疾患の制御2011
- Author(s)
  関谷　高史, 吉村　昭彦
- Organizer
  日本免疫学会総会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-23790346

1. YOSHIMURA Akihiko (90182815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. KIMURA Akihiro (20533318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SHICHITA Takashi (00598443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 杉山真也 (20612427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KURODA Tatsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KOBAYASHI Takaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. IWASAKI Kenta

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MIWA Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. ISHIYAMA Kohei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 森田林平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 森川康英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekiya Takashi 関谷 高史

SEKIYA Takashi 関谷 高史

関谷 高史 セキヤ タカシ

Research Projects

Research Products

Co-Researchers

ナイーブT細胞の不均一性に着目した組織特異的免疫応答の解明および免疫制御法の開発Principal Investigator

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Reprogramming of exhausted CTL by targeting enhancers with multi-dimensional regulatory activitiesPrincipal Investigator

Principal Investigator

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Mechanisms and meanings of phenotypic alteration of naive CD4 T cellsPrincipal Investigator

Principal Investigator

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IBD発症過程で生じるTh/Treg imbalanceの動態解析Principal Investigator

Principal Investigator

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Review Section

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CD4T細胞による「セルフ」の攻撃に作用する「ネオセルフ」抗原刺激の追求Principal Investigator

Principal Investigator

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Development of the novel screening method for reprogramming of inflammatory environmentPrincipal Investigator

Principal Investigator

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Analysis of autoimmune diseases pathogenesis with a novel reporter systemPrincipal Investigator

Principal Investigator

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Molecular mechanisms for CD4 T cell differentiation, aiming at generation of functional Treg cellsPrincipal Investigator

Principal Investigator

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Identification of Cellular Signaling Mechanism that regulates inflammation and tissue repairing

Principal Investigator

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Analysis of the molecular mechanisms which underlies the dynamiccharacteristics of regulatory T cell functionPrincipal Investigator

Principal Investigator

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エピジェネティック解析による制御性T細胞分化メカニズムの解明および異分化誘導Principal Investigator

Principal Investigator

Project Period (FY)

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[Book] Nr4aによるTh/Tregのバランス制御と炎症性疾患2021

Author(s)

Total Pages

Publisher

Data Source

[Book] Nr4aによるTh/Tregのバランス制御と炎症性疾患2021

Author(s)

Total Pages

Sekiya Takashi 関谷高史

SEKIYA Takashi 関谷高史

関谷高史セキヤタカシ

[Book] 医学のあゆみ制御性T細胞研究の現在2019

[Book] 医学のあゆみ　制御性T細胞研究の現在2019

[Book] 医学のあゆみ　制御性T細胞研究の現在2019

[Book] 医学のあゆみ　制御性T細胞研究の現在2019