Makino Tomoki 牧野知紀

… Alternative Names

Researcher Number	80528620
Other IDs
Affiliation (Current)	2019: 大阪大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2019: 大阪大学, 医学系研究科, 助教 2017: 大阪大学, 医学部附属病院, その他 2017: 大阪大学, 大学院医学系研究科, 助教 2016: 大阪大学, 医学系研究科, 助教 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2010: Osaka University, 医学部附属病院, その他 2009: Osaka University, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / General surgery / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 食道癌 / 化学療法 / 免疫組織染色 / RT-PCR / DNAマイクロアレイ / 蛋白発現解析 / 抗癌剤耐性 / ABCトランスポーター / 副作用 / MRP2 … More Except Principal Investigator 食道癌 / グレリン / 高齢者 / DNAマイクロアレイ / 化学療法感受性 / 放射線感受性 / P53 / 外科侵襲 / 胃癌 / 抗炎症 / 手術侵襲 / 抗炎症効果 / 気管再生 / 気管再建 / GIST / イマチニブ / 分子標的治療薬耐性 / imatinib / 耐性 / 消化管間質腫瘍 / 分子標的治療 / 薬剤耐性 / 腫瘍浸潤T細胞 / 制御性T細胞 / T細胞疲弊 / 免疫チェックポイント / 骨髄由来抑制細胞 / ghrelin / Oral Nutrition / mtDNA Less

Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunityOngoing
- Principal Investigator
  
  和田尚
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
上部消化管癌患者の予後向上を目指したグレリンによる周術期栄養療法の開発Ongoing
- Principal Investigator
  
  土岐祐一郎
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
ミトコンドリアDNAの動態制御による新規癌治療戦略の開発Ongoing
- Principal Investigator
  
  田中晃司
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
食道癌に対する化学+免疫療法の新規併用療法の確立に向けたバイオマーカー探索研究Principal InvestigatorOngoing
- Principal Investigator
  
  牧野知紀
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
気管浸潤食道癌に対する気管再生による合併切除再建Ongoing
- Principal Investigator
  
  山崎誠
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Development of a ghrelin supportive therapy for patients with high invasive surgery and highly morbidity risks
- Principal Investigator
  
  Takiguchi Shuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya City University
  Osaka University
Significance of ABC transporter in predicting response and adverse effect of chemotherapy for esophageal cancerPrincipal Investigator
- Principal Investigator
  
  Tomoki Makino
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Breakthrough in clinical application and optimization of ghrelin administration by clarifying the mechanism of alleviating surgical stress
- Principal Investigator
  
  Doki Yuichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
The mechanisms for acquired imatinib resistance beyond secondary KIT mutations in gastrointestinal stromal tumor
- Principal Investigator
  
  Takahashi Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Common経路とspecific経路による食道癌化学療法感受性の解析
- Principal Investigator
  
  Doki Yuichiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Osaka University
網羅的遺伝子発現解析を用いた食道癌に対する化学療法の感受性予測診断に関する研究Principal Investigator
- Principal Investigator
  
  牧野知紀
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University

All 2017 2016 2010 2009

All Journal Article Presentation

[Journal Article] 消化器がん特に上部消化管がん治療におけるグレリンの役割2017
- Author(s)
  宮﨑安弘、瀧口修司、高橋剛、黒川幸典、田中晃司、牧野知紀、山崎誠、中島清一、森正樹、土岐祐一郎
- Journal Title
  
  日本静脈経腸栄養学会雑誌
  
  Volume: 32 Pages: 811-816
- NAID
  130007040811
- Data Source
  KAKENHI-PROJECT-15H04930
[Journal Article] 消化器がん特に上部消化管がん治療におけるグレリンの役割2017
- Author(s)
  宮﨑安弘、瀧口修司、高橋剛、黒川幸典、田中晃司、牧野知紀、山崎誠、中島清一、森正樹、土岐祐一郎
- Journal Title
  
  日本静脈経腸栄養学会雑誌
  
  Volume: 32 Pages: 811-816
- NAID
  130007040811
- Data Source
  KAKENHI-PROJECT-15K10099
[Journal Article] Clinicopathological Characteristics, Surgery and Survival Outcomes of Patients with Duodenal Gastrointestinal Stromal Tumors.2016
- Author(s)
  Sugase T, Takahashi T, Nakajima K, Hirota S, Masuzawa T, Nishida T, Kimura Y, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Mori M, Doki Y.
- Journal Title
  
  Digestion
  
  Volume: 94 Pages: 30-36
- DOI
  10.1159/000447665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-15K10098
[Journal Article] Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial.2016
- Author(s)
  Yanagimoto Y, Takiguchi S, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Hosoda H, Kangawa K, Mori M, Doki Y
- Journal Title
  
  Br J Cancer
  
  Volume: 114 Pages: 1318-1325
- DOI
  10.1038/bjc.2016.160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04930, KAKENHI-PROJECT-15K10099, KAKENHI-PROJECT-16K10457
[Journal Article] Plasma ghrelin levels as a predictor of adverse renal events due to cisplatin-based chemotherapy in patients with esophageal cancer.2016
- Author(s)
  Yanagimoto Y, Takiguchi S, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Mori M, Doki Y
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 46 Pages: 21-426
- DOI
  10.1093/jjco/hyw004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04930, KAKENHI-PROJECT-15K10099, KAKENHI-PROJECT-16K10457
[Journal Article] Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in esophageal squamous cell carcinoma2010
- Author(s)
  Yamasaki M., Makino T., Masuzawa T., Kurokawa Y., Miyata H., Takiguchi S., Nakajima K., Fujiwara Y., Matsuura N., Mori M., Doki Y
- Journal Title
  
  Br J Cancer
  
  Volume: (in Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659302
[Journal Article] Utility of response evaluation to neo-adjuvant chemotherapy by (18)F-fluorodeoxyglucose-positron emission tomography in locally advanced esophageal squamous cell carcinoma2010
- Author(s)
  Makino T., Miyata H., Yamasaki M., Fujiwara Y., Takiguchi S., Nakajima K., Higuchi I., Hatazawa J., Mori M., Doki Y
- Journal Title
  
  Surgery
  
  Volume: 148(5) Pages: 908-918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659302
[Journal Article] :p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer2010
- Author(s)
  Makino T., Yamasaki M., Miyata H., Yoshioka S., Takiguchi S., Fujiwara Y., Nakajima K., Nishida T., Mori M., Doki Y
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 17(3) Pages: 804-811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659302
[Journal Article] 食道癌におけるDKK1発現の意義の研究2009
- Author(s)
  牧野知紀, ほか
- Journal Title
  
  Annals of Surgical Oncology 7
  
  Pages: 1298-1306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791286
[Journal Article] Dickkopf-1 expression as a marker for predicting clinical outcome in esophageal squamous cell carcinoma.2009
- Author(s)
  Makino T., et. al
- Journal Title
  
  Ann Surg Oncol. 16(17)
  
  Pages: 2058-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659302
[Journal Article] p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer.2009
- Author(s)
  Makino T., et. al
- Journal Title
  
  Ann Surg Oncol 17(3)
  
  Pages: 804-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659302
[Journal Article] 食道癌におけるCK18およびCK8発現の意義の研究2009
- Author(s)
  牧野知紀, ほか
- Journal Title
  
  British Journal of Cancer 8
  
  Pages: 2058-2064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791286
[Journal Article] Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus2009
- Author(s)
  Makino T., et. al
- Journal Title
  
  Br J Cancer 101(8)
  
  Pages: 1298-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659302
[Presentation] 消化管間葉系肉腫（GIST）に対する分子標的治療耐性メカニズムの検討2017
- Author(s)
  高橋剛、黒川幸典、西田俊朗、廣田誠一、西垣貴彦、和田範子、田中晃司、宮崎安弘、牧野知紀、山崎誠、中島清一、瀧口修司、森正樹、土岐祐一郎
- Organizer
  日本癌転移学会
- Data Source
  KAKENHI-PROJECT-15K10098
[Presentation] 消化管間葉系肉腫（GIST）に対する分子標的治療耐性メカニズムの検討2016
- Author(s)
  高橋剛、黒川幸典、西田俊朗、廣田誠一、西垣貴彦、和田範子、田中晃司、宮崎安弘、牧野知紀、山崎誠、中島清一、瀧口修司、森正樹、土岐祐一郎
- Organizer
  日本消化器癌発生学会
- Place of Presentation
  鹿児島
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-15K10098
[Presentation] 癌治療における六君子湯の役割～グレリンに対する作用から臨床への応用～消化器外科の立場から－胃切除後消化器関連合併症に対する六君子湯投与の影響－2016
- Author(s)
  宮崎安弘, 新野直樹, 額原敦, 黒川幸典, 高橋剛, 山崎誠, 牧野知紀, 瀧口修司, 中島清一, 森正樹, 土岐祐一郎
- Organizer
  第54回日本癌治療学会学術集会
- Place of Presentation
  横浜(パシフィコ横浜)
- Invited
- Data Source
  KAKENHI-PROJECT-15H04930
[Presentation] 食道扁平上皮癌におけるサイトケラチン18(CK18)発現の意義2009
- Author(s)
  牧野知紀, ほか
- Organizer
  日本外科学会
- Place of Presentation
  福岡
- Year and Date
  2009-04-02
- Data Source
  KAKENHI-PROJECT-21791286

1. Yamasaki Makoto (50444518)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. Kurokawa Yukinori (10470197)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
3. Takahashi Tsuyoshi (50452389)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
4. Miyazaki Yasuhiro (00571390)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
5. Doki Yuichiro (20291445)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. Tanaka Kouji (70621019)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
7. Takiguchi Shuji (00301268)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
8. 宮田博志 (80362713)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
9. 新野直樹 (10724122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 柳本喜智 (70645085)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. KANGAWA Kenji (00112417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 藤原義之 (40314330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 山本昌明 (20724280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中島清一 (30432537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小田切数基 (30781794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 百瀬洸太 (50749752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 和田尚 (70243459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐藤永一 (60408101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 垣見和宏 (80273358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岩堀幸太 (80566448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 森本晶子 (60601193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山下公太郎 (20747159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 山田萌 (00781717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 松浦記大 (90804477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 廣田誠一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Makino Tomoki 牧野 知紀

Tomoki Makino 牧野 知紀

牧野 知紀 マキノ トモキ

Research Projects

Research Products

Co-Researchers

Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunityOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

上部消化管癌患者の予後向上を目指したグレリンによる周術期栄養療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミトコンドリアDNAの動態制御による新規癌治療戦略の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

食道癌に対する化学+免疫療法の新規併用療法の確立に向けたバイオマーカー探索研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

気管浸潤食道癌に対する気管再生による合併切除再建Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a ghrelin supportive therapy for patients with high invasive surgery and highly morbidity risks

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of ABC transporter in predicting response and adverse effect of chemotherapy for esophageal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Breakthrough in clinical application and optimization of ghrelin administration by clarifying the mechanism of alleviating surgical stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms for acquired imatinib resistance beyond secondary KIT mutations in gastrointestinal stromal tumor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Common経路とspecific経路による食道癌化学療法感受性の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

網羅的遺伝子発現解析を用いた食道癌に対する化学療法の感受性予測診断に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 消化器がん特に上部消化管がん治療におけるグレリンの役割2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 消化器がん特に上部消化管がん治療におけるグレリンの役割2017

Author(s)

Journal Title

Makino Tomoki 牧野知紀

Tomoki Makino 牧野知紀

牧野知紀マキノトモキ

[Presentation] 癌治療における六君子湯の役割～グレリンに対する作用から臨床への応用～消化器外科の立場から－胃切除後消化器関連合併症に対する六君子湯投与の影響－2016