Kawahara Yukio 河原行郎

… Alternative Names

KAWAHARA Yukio 河原行郎

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Researcher Number	80542563
Other IDs
Affiliation (Current)	2023: 大阪大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 大学院医学系研究科, 教授 2016 – 2022: 大阪大学, 医学系研究科, 教授 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 教授 2012 – 2013: 大阪大学, 医学(系)研究科(研究院), 准教授 2012: 大阪大学, 大学院・医学系研究科, 特任准教授 (常勤) 2011: 大阪大学, 医学(系)研究科(研究院), 特任准教授(常勤) 2009 – 2011: Osaka University, 医学系研究科, 特任准教授(常勤)
Review Section/Research Field	Principal Investigator Neurology / Biological Sciences / Basic Section 46010:Neuroscience-general-related / Medium-sized Section 51:Brain sciences and related fields / Molecular and Genome biology and related fields Except Principal Investigator Basic Section 62010:Life, health and medical informatics-related / Structural biochemistry / Cardiovascular medicine
Keywords	Principal Investigator 遺伝子 / 脳神経疾患 / RNA / 痴呆 / 筋萎縮性側索硬化症 / 神経変性疾患 / ALS / 脳・神経 / RNA修飾 / 細胞死 … More / RNA結合タンパク質 / 脊髄小脳変性症 / 神経分子病態学 / 細胞・組織 / 神経科学 / 核酸 / エカルディ・グティエール症候群 / 自然免疫 / RNA編集 / 発生・分化 / 疾患モデルマウス / 神経細胞 / TU tagging / 中枢神経 / マウス / RNAラベリング / 遺伝子発現 / 肥満 / ガン / エピトランスクリプトーム / メチル化 / m6A / 脳神経組織 / RNA代謝 / 子宮筋腫 / 精神遅滞 / 非コードRNA / 転写 / アポトーシス / ネクローシス / 前頭側頭葉変性症 / カスパーゼ / ウイルス / 転写後修飾 / 糖尿病 … More Except Principal Investigator 深層学習 / ナノポアシークエンサー / RNA修飾 / RNA二次構造 / バイオインフォマティクス / ncRNA / CLIP法 / ノンコーディングRNA / Xist / RBM15 / NMR / XIST / SRA / SHARP / lncRNA / メタボロミクス / マイクロRNA / 虚血性心不全 Less

RNA編集不全に起因する自己免疫性脳症発症メカニムズの解明Principal Investigator
- Principal Investigator
  
  河原行郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Osaka University
修飾塩基を含むRNAの二次構造解析技術の確立
- Principal Investigator
  
  佐藤健吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Tokyo Denki University
RNA編集酵素ADAR1の脳特異的機能の解明Principal Investigator
- Principal Investigator
  
  河原行郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Osaka University
Establishment of the mothod for RNA labelling in a neuron subtype-specific manner in vivoPrincipal Investigator
- Principal Investigator
  
  Kawahara Yukio
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka University
RNA secondary structure prediction using nanopore sequencers
- Principal Investigator
  
  佐藤健吾
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Keio University
Establishment of the mothod to quantify methylation efficiency at a specific sitePrincipal Investigator
- Principal Investigator
  
  Kawahara Yukio
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Molecular and Genome biology and related fields
- Research Institution
  Osaka University
Eluciadation of the mechanism underlying selective neuronal death mediated by dysregulation of RNA-binding proteinsPrincipal Investigator
- Principal Investigator
  
  Kawahara Yukio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Exploration for microRNAs to predict prognosis in ishemic heart failure
- Principal Investigator
  
  SAKATA YASUHIKO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Tohoku University
非コードRNAとの結合を介したMediator複合体による転写制御機構の解明Principal Investigator
- Principal Investigator
  
  河原行郎
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Structural basis of transcriptional repression by SRA, a long non-coding RNA
- Principal Investigator
  
  MISHIMA Masaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Metropolitan University
ALSと脊髄小脳変性症に共通した発症病態の解明Principal Investigator
- Principal Investigator
  
  河原行郎
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Elucidation of Ataxin-2-mediated neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Kawahara Yukio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
The biological significance of the cleavage of ALS-associated protein TDP-43Principal Investigator
- Principal Investigator
  
  KAWAHARA Yukio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Osaka University
ＡＬＳの病態解明に向けたＲＮＡ結合蛋白質ＴＤＰ－４３及びＦＵＳの網羅的機能解析Principal Investigator
- Principal Investigator
  
  河原行郎
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Challenge for the identification of ALS-related virusesPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Yukio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Elucidation of the role of TDP-43 in microRNA biogenesis and ALS pathogenesisPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Yukio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
アミノ酸配列の置換を生じるRNA編集の生理的意義の解明Principal Investigator
- Principal Investigator
  
  河原行郎
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

[Book] Post-transcriptional gene regulation: RNA processing in eukaryotes.2013
- Author(s)
  2. Valente, L., Kawahara, Y., Zinshteyn, B., Iizasa, H., Nishikura, K.
- Total Pages
  42
- Publisher
  Wiley-VCH book
- Data Source
  KAKENHI-PUBLICLY-25110719
[Book] Post-transcriptional gene regulation2011
- Author(s)
  ルイスバレンチ、河原行郎
- Publisher
  Wiley-VCH book社(印刷中)
- Data Source
  KAKENHI-PROJECT-22390176
[Book] Post-transcriptional gene regulation2011
- Author(s)
  ルイスバレンチ、河原行郎
- Publisher
  Wiley-VCH book社(印刷中)
- Data Source
  KAKENHI-PUBLICLY-21112515
[Book] Post-transcriptional gene regulation2010
- Author(s)
  ルイスバレンチ、河原行郎
- Publisher
  Wiley-VCH book社(印刷中)
- Data Source
  KAKENHI-PUBLICLY-21112515
[Journal Article] RNAの巻き方を感知する自然免疫システム2022
- Author(s)
  中濱　泰祐、河原　行郎
- Volume
  40
- Pages
  544
- DOI
  10.18958/6991-00001-0000065-00
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20H03341
[Journal Article] RNA編集を応用した核酸医薬開発への展望2021
- Author(s)
  河原　行郎
- Journal Title
  
  実験医学（増刊）
  
  Volume: 39 Pages: 2772-2778
- Data Source
  KAKENHI-PROJECT-20H03341
[Journal Article] An Aicardi-Goutieres Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice2021
- Author(s)
  Inoue Maal、Nakahama Taisuke、Yamasaki Ryuichiro、Shibuya Toshiharu、Kim Jung In、Todo Hiroyuki、Xing Yanfang、Kato Yuki、Morii Eiichi、Kawahara Yukio
- Journal Title
  
  The Journal of Immunology
  
  Volume: 207 Issue: 12 Pages: 3016-3027
- DOI
  10.4049/jimmunol.2100526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03341, KAKENHI-PROJECT-20J11266, KAKENHI-PROJECT-18K11526, KAKENHI-PROJECT-21K07080, KAKENHI-PROJECT-21K12109
[Journal Article] Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutieres-syndrome-like encephalopathy2021
- Author(s)
  Nakahama Taisuke、Kato Yuki、Shibuya Toshiharu、Inoue Maal、Kim Jung In、Vongpipatana Tuangtong、Todo Hiroyuki、Xing Yanfang、Kawahara Yukio
- Journal Title
  
  Immunity
  
  Volume: 54 Issue: 9 Pages: 1976-1988
- DOI
  10.1016/j.immuni.2021.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03341, KAKENHI-PROJECT-20J11266, KAKENHI-PROJECT-18K11526, KAKENHI-PROJECT-21K07080, KAKENHI-PROJECT-21K12109
[Journal Article] RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain2021
- Author(s)
  Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
- Journal Title
  
  PLoS Genetics
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22580
[Journal Article] Deciphering the Biological Significance of ADAR1-Z-RNA Interactions2021
- Author(s)
  Nakahama Taisuke、Kawahara Yukio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11435-11435
- DOI
  10.3390/ijms222111435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03341, KAKENHI-PROJECT-21K07080
[Journal Article] RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain2021
- Author(s)
  Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
- Journal Title
  
  PLoS Genetics
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03341
[Journal Article] エピトランスクリプトーム2020
- Author(s)
  河原　行郎
- Journal Title
  
  炎症と免疫
  
  Volume: 28(6) Pages: 546-550
- Data Source
  KAKENHI-PROJECT-20H03341
[Journal Article] A Comparative Analysis of ADAR Mutant Mice Reveals Site-Specific Regulation of RNA Editing2020
- Author(s)
  Pedro Henrique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara
- Journal Title
  
  RNA
  
  Volume: 26(4) Issue: 4 Pages: 454-469
- DOI
  10.1261/rna.072728.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22580, KAKENHI-PROJECT-18K15186, KAKENHI-PROJECT-18K11526
[Journal Article] エピトランスクリプトーム2020
- Author(s)
  河原　行郎
- Journal Title
  
  炎症と免疫
  
  Volume: 28(6) Pages: 546-550
- Data Source
  KAKENHI-PROJECT-19K22580
[Journal Article] ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways2020
- Author(s)
  Vongpipatana T, Nakahama T, Shibuya T, Kato Y, Kawahara Y
- Journal Title
  
  The Jorunal of Immunology
  
  Volume: 204(8) Issue: 8 Pages: 2156-2168
- DOI
  10.4049/jimmunol.1900929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22580, KAKENHI-PROJECT-18K15186, KAKENHI-PROJECT-18J11733, KAKENHI-PROJECT-18K11526
[Journal Article] Quantification of methylation efficiency at a specific N6-methyladenosine position in rRNA by using BNA probes2018
- Author(s)
  Oshima Takuya、Ishiguro Kensuke、Suzuki Tsutomu、Kawahara Yukio
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 69 Pages: 9627-9630
- DOI
  10.1039/c8cc03713b
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-16H05320, KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-18H05272
[Journal Article] ADAR1-mediated RNA editing is required for thymic self-tolerance and prevention of autoimmunity2018
- Author(s)
  Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl Walkley and Yukio Kawahara
- Journal Title
  
  EMBO Reports
  
  Volume: 19 Issue: 12
- DOI
  10.15252/embr.201846303
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11526, KAKENHI-PROJECT-18K15186, KAKENHI-PROJECT-16H05320, KAKENHI-PROJECT-18J11733, KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H06279
[Journal Article] Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing2017
- Author(s)
  Uemura Y, Oshima T, Yamamoto M, Reyes CJ, Costa Cruz PH, Shibuya T, Kawahara Y
- Journal Title
  
  Genes to Cells
  
  Volume: 22(9) Issue: 9 Pages: 785-798
- DOI
  10.1111/gtc.12512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H05320
[Journal Article] RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin.2017
- Author(s)
  Gallego A, Hartasanchez DA, Braso-Vives M, Garcia-Ramallo E, Lopez-Valenzuela M, Baena N, Guitart M, Fernandez-Bellon H, Kondova I, Bontrop R, Kawahara Y, Espinosa-Parrilla Y
- Journal Title
  
  Gene
  
  Volume: 628 Pages: 109-116
- DOI
  10.1016/j.gene.2017.07.032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H05320
[Journal Article] The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain2017
- Author(s)
  Kanemitsu Y, Fujitani M, Fujita Y, Zhang S, Su YQ, Kawahara Y, Yamashita T
- Journal Title
  
  Scientific Reports
  
  Volume: 7(1) Issue: 1 Pages: 1155-1155
- DOI
  10.1038/s41598-017-01317-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H05320
[Journal Article] CLIP法とその改良法によるタンパク質結合RNAの高解像度解析2016
- Author(s)
  河原行郎
- Journal Title
  
  実験医学(別冊)
  
  Volume: 1 Pages: 149-158
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Journal Article] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016
- Author(s)
  Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
- Journal Title
  
  Cell Reports
  
  Volume: 17 Issue: 8 Pages: 2004-2014
- DOI
  10.1016/j.celrep.2016.10.073
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01471, KAKENHI-PUBLICLY-16H01615, KAKENHI-PLANNED-25117006, KAKENHI-PROJECT-16H05320, KAKENHI-PROJECT-26292150, KAKENHI-PROJECT-15K18342, KAKENHI-PROJECT-16K07100, KAKENHI-PROJECT-25000015
[Journal Article] CLIP法とその改良法によるタンパク質結合RNAの高解像度解析2016
- Author(s)
  河原行郎
- Journal Title
  
  実験医学(別冊)
  
  Volume: 1 Pages: 149-158
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] Cross-Linking and Immunopresipitation of Nuclear RNA-Binding Proteins2015
- Author(s)
  Li,Q., Uemura,Y., Kawahara,Y.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1262 Pages: 247-263
- DOI
  10.1007/978-1-4939-2253-6_15
- ISBN
  9781493922529, 9781493922536
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J01433, KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419
[Journal Article] RNA代謝異常を介した神経変性疾患の発症病態2015
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  ファルマシア
  
  Volume: 51(1) Pages: 37-41
- NAID
  130007447862
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] 自己免疫疾患とRNA編集2015
- Author(s)
  三宅浩太郎, 中濱泰祐, 河原行郎
- Journal Title
  
  実験医学(増刊)
  
  Volume: 33(20) Pages: 3339-3344
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] RNA代謝異常を介した神経変性疾患の発症病態2015
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  ファルマシア
  
  Volume: 51(1) Pages: 37-41
- NAID
  130007447862
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] マイクロRNA2015
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  生体の科学
  
  Volume: 66(5) Pages: 478-479
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Journal Article] The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.2015
- Author(s)
  Li, Q., Yokoshi, M., Okada, H., Kawahara, Y.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6183-6183
- DOI
  10.1038/ncomms7183
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419
[Journal Article] 自己免疫疾患とRNA編集2015
- Author(s)
  三宅浩太郎, 中濱泰祐, 河原行郎
- Journal Title
  
  実験医学(増刊)
  
  Volume: 33(20) Pages: 3339-3344
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Journal Article] 神経疾患をmicroRNAで診断する2015
- Author(s)
  河原行郎
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 33(11) Pages: 1302-1304
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Journal Article] マイクロRNA2015
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  生体の科学
  
  Volume: 66(5) Pages: 478-479
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] 神経疾患をmicroRNAで診断する2015
- Author(s)
  河原行郎
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 33(11) Pages: 1302-1304
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] RNA代謝異常を介した神経変性疾患の発症病態2015
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  ファルマシア
  
  Volume: 51(1) Pages: 37-41
- NAID
  130007447862
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] 神経変性疾患の発症メカニズムUp-to-Date2015
- Author(s)
  河原行郎
- Journal Title
  
  BIO Clinica
  
  Volume: 30(7) Pages: 705-708
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] RNA疾患研究の新展開2014
- Author(s)
  河原行郎, 塩見美喜子
- Journal Title
  
  Medical Science Digest
  
  Volume: 40(7) Pages: 324-325
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] RNA疾患研究の新展開2014
- Author(s)
  河原行郎, 塩見美喜子
- Journal Title
  
  Medical Science Digest
  
  Volume: 40(7) Pages: 324-325
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] RNA代謝と神経変性2014
- Author(s)
  植村有里, 河原行郎
- Journal Title
  
  Brain Medical
  
  Volume: 26(3) Pages: 209-215
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] RNA代謝と神経変性2014
- Author(s)
  植村有里, 河原行郎
- Journal Title
  
  Brain Medical
  
  Volume: 26(3) Pages: 209-215
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる2014
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  新着論文レビュー
  
  Volume: e9044
- Open Access
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.2014
- Author(s)
  Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., and Kawahara, Y.
- Journal Title
  
  Molecular cell
  
  Volume: 55 Issue: 2 Pages: 186-198
- DOI
  10.1016/j.molcel.2014.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J01452, KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419, KAKENHI-PROJECT-221S0002
[Journal Article] 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる2014
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  新着論文レビュー
  
  Volume: e9044
- Open Access
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] RNA代謝と神経変性2014
- Author(s)
  植村有里, 河原行郎
- Journal Title
  
  Brain Medical
  
  Volume: 26(3) Pages: 209-215
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes.2014
- Author(s)
  Kawahara, Y
- Journal Title
  
  Congenital Anomalies
  
  Volume: 54 Issue: 1 Pages: 12-21
- DOI
  10.1111/cga.12043
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419
[Journal Article] RNA疾患研究の新展開2014
- Author(s)
  河原行郎, 塩見美喜子
- Journal Title
  
  Medical Science Digest
  
  Volume: 40(7) Pages: 324-325
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる2014
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  新着論文レビュー
  
  Volume: e9044
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] microRNAの修飾とその機能2013
- Author(s)
  余越　萌、河原　行郎
- Journal Title
  
  実験医学（増刊）
  
  Volume: 31 Pages: 1124-1131
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] microRNA の機能とその修飾.2013
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  実験医学(増刊)
  
  Volume: 31(7) Pages: 160-167
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] ノンコーディングRNAと神経変性疾患2013
- Author(s)
  河原　行郎
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 421-426
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] microRNAの修飾とその機能2013
- Author(s)
  余越　萌、河原　行郎
- Journal Title
  
  実験医学（増刊）
  
  Volume: 31 Pages: 1124-1131
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] ノンコーディングRNAと神経変性疾患2013
- Author(s)
  河原　行郎
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 421-426
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] 筋萎縮性側索硬化症とRNA結合タンパク質2013
- Author(s)
  河原　行郎
- Journal Title
  
  領域融合レビュー
  
  Volume: e010 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25110719
[Journal Article] 筋萎縮性側索硬化症とRNA結合タンパク質2013
- Author(s)
  河原　行郎
- Journal Title
  
  領域融合レビュー
  
  Volume: e010 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] microRNAの修飾とその機能2013
- Author(s)
  余越　萌、河原　行郎
- Journal Title
  
  実験医学（増刊）
  
  Volume: 31 Pages: 1124-1131
- Data Source
  KAKENHI-PROJECT-25293201
[Journal Article] ノンコーディングRNAと神経変性疾患2013
- Author(s)
  河原　行郎
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 421-426
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] 筋萎縮性側索硬化症とRNA結合タンパク質2013
- Author(s)
  河原　行郎
- Journal Title
  
  領域融合レビュー
  
  Volume: e010 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670419
[Journal Article] microRNAの機能とその修飾2013
- Author(s)
  余越萌, 河原行郎
- Journal Title
  
  実験医学(増刊)
  
  Volume: 31(7) Pages: 160-167
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes2012
- Author(s)
  Kawahara Y and Mieda-Sato I
- Journal Title
  
  Proceedings of the National Academy of Sciences U.S.A.
  
  Volume: 109(9) Pages: 3347-3352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction2012
- Author(s)
  Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 427(2) Pages: 280-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes2012
- Author(s)
  河原行郎、佐藤愛
- Journal Title
  
  米国科学アカデミー紀要
  
  Volume: 109(9) Pages: 3347-3352
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112712
[Journal Article] Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm.2012
- Author(s)
  Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Kawahara Y, Daimon T, Kuratani T, Sawa Y
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] Quantification of A-to-I editing of microRNAs using aconventional method.2012
- Author(s)
  Kawahara Y
- Journal Title
  
  Nature Protocols
  
  Volume: 7(7) Pages: 1426-1437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes2012
- Author(s)
  河原行郎、佐藤愛
- Journal Title
  
  米国科学アカデミー紀要
  
  Volume: 109(9) Pages: 3347-3352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction2012
- Author(s)
  Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 427(2) Pages: 280-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] Quantification of A-to-I editing of microRNAs using a conventional method2012
- Author(s)
  Kawahara Y
- Journal Title
  
  Nature Protocols
  
  Volume: 7(7) Pages: 1426-1437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] microRNA2012
- Author(s)
  河原行郎
- Journal Title
  
  分子脳血管病
  
  Volume: 11(4) Pages: 431-434
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.2012
- Author(s)
  Kawahara Y and Mieda-Sato I.
- Journal Title
  
  Proceedings of the National Academy of Sciences U. S. A
  
  Volume: 109(9) Pages: 3347-3352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm.2012
- Author(s)
  Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Kawahara Y, Daimon T, Kuratani T, Sawa Y.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] Quantification of A-to-I editing of microRNAs using a conventional method.2012
- Author(s)
  Yukio Kawahara
- Journal Title
  
  Nature Protocols
  
  Volume: 7 Issue: 7 Pages: 1426-1437
- DOI
  10.1038/nprot.2012.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01413, KAKENHI-PROJECT-22390176, KAKENHI-PROJECT-23659453, KAKENHI-ORGANIZER-20112001, KAKENHI-PUBLICLY-23112712
[Journal Article] microRNA2012
- Author(s)
  河原行郎
- Journal Title
  
  分子脳血管病
  
  Volume: 11(4) Pages: 431-434
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] マイクロRNA2011
- Author(s)
  河原行郎
- Journal Title
  
  分子精神医学
  
  Volume: 11(3) Pages: 172-177
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] マイクロRNA2011
- Author(s)
  河原行郎
- Journal Title
  
  分子精神医学
  
  Volume: 11(3) Pages: 172-177
- Data Source
  KAKENHI-PUBLICLY-23112712
[Journal Article] マイクロ RNA2011
- Author(s)
  河原行郎
- Journal Title
  
  分子精神医学
  
  Volume: 11(3) Pages: 172-177
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] RNA編集の異常と関連する疾患2010
- Author(s)
  河原行郎
- Journal Title
  
  実験医学印刷中
- Data Source
  KAKENHI-PUBLICLY-21112515
[Journal Article] RNA編集の異常と関連する疾患2010
- Author(s)
  河原行郎
- Journal Title
  
  実験医学(増刊)
  
  Volume: 28 Pages: 1628-1635
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] microRNA 発現の転写後調節機構.2010
- Author(s)
  河原行郎
- Journal Title
  
  生体の科学
  
  Volume: 61(4) Pages: 308-314
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] RNA 編集の異常と関連する疾患2010
- Author(s)
  河原行郎
- Journal Title
  
  実験医学(増刊)
  
  Volume: 28 Pages: 1628-1635
- Data Source
  KAKENHI-PROJECT-23659453
[Journal Article] microRNA発現の転写後調節機構2010
- Author(s)
  河原行郎
- Journal Title
  
  生体の科学
  
  Volume: 61(4) Pages: 308-314
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] microRNA発現の転写後調節機構2010
- Author(s)
  河原行郎
- Journal Title
  
  生体の科学
  
  Volume: 61巻 Pages: 308-314
- Data Source
  KAKENHI-PUBLICLY-21112515
[Journal Article] RNA編集の異常と関連する疾患2010
- Author(s)
  河原行郎
- Journal Title
  
  実験医学
  
  Volume: 28巻 Pages: 1628-1635
- Data Source
  KAKENHI-PUBLICLY-21112515
[Journal Article] Functional relevance of serotonin 2C receptor mRNA editing in anti-depressant- and anxiety-like behabiors.2010
- Author(s)
  セドリックモンブリュー、河原行郎
- Journal Title
  
  Neuropharmacology
  
  Volume: 59巻 Pages: 468-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] Functional relevance of serotonin 2C receptor mRNA editing in anti-depressant- and anxiety-like bebabiors.2010
- Author(s)
  セドリックモンブリュー、河原行郎
- Journal Title
  
  Neuropharmacology
  
  Volume: 59巻 Pages: 468-473
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21112515
[Journal Article] RNA編集の異常と関連する疾患2010
- Author(s)
  河原行郎
- Journal Title
  
  実験医学
  
  Volume: 28巻 Pages: 1628-1635
- Data Source
  KAKENHI-PROJECT-22390176
[Journal Article] RNA編集によるmiRNAの機能調節2009
- Author(s)
  河原行郎、西倉和子
- Journal Title
  
  蛋白質核酸酵素 VOL.54
  
  Pages: 1133-1140
- NAID
  40016708050
- Data Source
  KAKENHI-PUBLICLY-21112515
[Journal Article] RNA編集から疾患治療へ2009
- Author(s)
  河原行郎、西倉和子
- Journal Title
  
  遺伝子医学MOOK 最新RNAと疾患研究 15巻
  
  Pages: 174-180
- Data Source
  KAKENHI-PUBLICLY-21112515
[Presentation] Deciphering the biological significance of ADAR1-Z-RNA interactions2021
- Author(s)
  Yukio Kawahara
- Organizer
  A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03341
[Presentation] RNA編集研究の最前線：基礎、病態、そして治療法への応用について2020
- Author(s)
  河原　行郎
- Organizer
  核酸医薬シンポジウム2020
- Invited
- Data Source
  KAKENHI-PROJECT-20H03341
[Presentation] The physiological significance of RNA editing in maintaining brain homeostasis2020
- Author(s)
  Yuko Kawahara
- Organizer
  第４３回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22580
[Presentation] The physiological significance of RNA editing in maintaining brain homeostasis2020
- Author(s)
  Yuko Kawahara
- Organizer
  第４３回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03341
[Presentation] RNA編集研究の最前線：基礎、病態、そして治療法への応用について2020
- Author(s)
  河原　行郎
- Organizer
  核酸医薬シンポジウム2020
- Invited
- Data Source
  KAKENHI-PROJECT-19K22580
[Presentation] Precise determination of responsible ADARs for each RNA editing site in vivo2019
- Author(s)
  Pedro Herique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara
- Organizer
  Gordon Research Conference & Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19352
[Presentation] ADAR1-mediated RNA editing is required for thymic selftolerance and inhibition of autoimmunity2019
- Author(s)
  Nakahama T, Kato Y, Kim JI, Vongpipatana T, Suzuki Y, Walkley CR, Kawahara Y
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19352
[Presentation] ADAR1 regulates early T cell development via MDA5-dependent and -independent pathways2019
- Author(s)
  Tuangtong Vogpipatana, Taisuke Nakahama, Yuki Kato, Carl Walkley and Yukio Kawahara
- Organizer
  Gordon Research Conference & Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19352
[Presentation] TDP-43ノックインマウスにおける神経変性病態2018
- Author(s)
  河原　行郎
- Organizer
  第３７回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] ALS発症機構の解明に向けたTDP-43ノックインマウスの作製と解析2018
- Author(s)
  河原　行郎
- Organizer
  第一回三融会・武田神経科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] TDP-43ノックインマウスを用いたALS発症病態の解析2018
- Author(s)
  河原　行郎
- Organizer
  第５９回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] The role of ADAR1-mediated RNA editing in development2017
- Author(s)
  Yukio Kawahara
- Organizer
  ConBio2017 (2017年度) 生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19352
[Presentation] The role of RNA editing in T cell development2017
- Author(s)
  Yukio Kawahara
- Organizer
  第４３回内藤カンファランス
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19352
[Presentation] Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing2017
- Author(s)
  Yuri Uemura, Takuya Oshima1, Munetaka Yamamoto, Charles Jourdan Reyes, Pedro Herique Costa Cruz, Toshiharu Shibuya, Yukio Kawahara
- Organizer
  RNA2017, The 22nd annual meeting of the RNA society
- Data Source
  KAKENHI-PROJECT-17K19352
[Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2017
- Author(s)
  Nakahama T, Walkley C, Kawahara Y.
- Organizer
  Gordon Research Conference on RNA editing
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2017
- Author(s)
  Nakahama T, Walkley C, Kawahara Y.
- Organizer
  Gordon Research Conference on RNA editing
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2017
- Author(s)
  Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
- Organizer
  Gordon Research Conference on RNA editing
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2017
- Author(s)
  Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
- Organizer
  Gordon Research Conference on RNA editing
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016
- Author(s)
  河原　行郎
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2016
- Author(s)
  Nakahama T, Walkley C, Kawahara Y.
- Organizer
  第４５回日本免疫学会学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16H05320
[Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016
- Author(s)
  河原　行郎
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2016
- Author(s)
  Nakahama T, Walkley C, Kawahara Y.
- Organizer
  第４５回日本免疫学会学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PUBLICLY-15H01471
[Presentation] 分泌型マイクロRNAの医療応用への期待と課題2015
- Author(s)
  河原　行郎
- Organizer
  第５５回臨床化学会
- Place of Presentation
  大阪
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] U-rich RNA 結合タンパク質Ataxin-2 はmRNA を安定化する2015
- Author(s)
  余越萌, 李全, 山本宗隆, 岡田ひとみ, 鈴木穣, 河原行郎
- Organizer
  RNAフロンティアミーティング2015
- Place of Presentation
  山形
- Year and Date
  2015-12-08
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] RNA binding proteins involved in neurodegeneration2014
- Author(s)
  Kawahara, Y
- Organizer
  第12回日本プロテオーム学会年会
- Place of Presentation
  筑波　茨城
- Year and Date
  2014-06-18
- Invited
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] Elucidation of Ataxin-2-mediated regulation of RNA metabolism2014
- Author(s)
  Kawahara, Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜　神奈川
- Year and Date
  2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] Identification of common targets of TDP-43 and FUS by PAR-CLIP.2014
- Author(s)
  1. Li, Q., Yamamoto, M., Yokoshi, M., Suzuki, Y., Kawahara Y.,
- Organizer
  New Frontier of Molecular Neruopathology 2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25670419
[Presentation] Toward a comprehensive analysis of Ataxin-2 functions for the understanding of a common mechanism underlying neurodegeneration2014
- Author(s)
  Kawahara, Y
- Organizer
  第91回日本生理学会年会
- Place of Presentation
  鹿児島
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Identification of common targets of TDP-43 and FUS by PAR-CLIP.2014
- Author(s)
  1. Li, Q., Yamamoto, M., Yokoshi, M., Suzuki, Y., Kawahara Y.
- Organizer
  New Frontier of Molecular Neruopathology 2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Toward a comprehensive analysis of Ataxin-2 functions for the understanding of a common mechanism underlying neurodegeneration2014
- Author(s)
  Kawahara, Y
- Organizer
  第91回日本生理学会年会
- Place of Presentation
  鹿児島
- Invited
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] TDP-43断片化の生理的意義について2014
- Author(s)
  河原　行郎
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  博多　福岡
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25670419
[Presentation] Identification of common targets of TDP-43 and FUS by PAR-CLIP.2014
- Author(s)
  Li, Q., Yamamoto, M., Yokoshi, M., Suzuki, Y., Kawahara Y.
- Organizer
  New Frontier of Molecular Neruopathology 2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] Elucidation of Ataxin-2-mediated regulation of RNA metabolism2014
- Author(s)
  Kawahara, Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜　神奈川
- Year and Date
  2014-09-11
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Ataxin-2の生理的機能とpolyQ鎖伸長の病的意義について2014
- Author(s)
  河原　行郎
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  名古屋　愛知
- Year and Date
  2014-07-23
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Ataxin-2の生理的機能とpolyQ鎖伸長の病的意義について2014
- Author(s)
  河原　行郎
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  名古屋　愛知
- Year and Date
  2014-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] RNA binding proteins involved in neurodegeneration2014
- Author(s)
  Kawahara, Y
- Organizer
  第12回日本プロテオーム学会年会
- Place of Presentation
  筑波　茨城
- Year and Date
  2014-06-18
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] PAR-CLIP法を用いたTDP-43とFUSに共通するターゲットの同定2013
- Author(s)
  山本　宗隆、李　全、鈴木　穣、河原　行郎
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PROJECT-25670419
[Presentation] Comprehensive analysis of the roles of TDP-43 and FUS in RNA processing2013
- Author(s)
  Li, Q., Yamamoto, M., Seno, S., Matsuda, H., Suzuki, Y., Kawahara Y.
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] PAR-CLIP法を用いたTDP-43とFUSに共通するターゲットの同定2013
- Author(s)
  山本　宗隆、李　全、鈴木　穣、河原　行郎
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] Toward a comprehensive functional analysis of Ataxin-2 for the understanding of a common mechanism underlying neurodegeneration2013
- Author(s)
  Kawahara, Y
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Comprehensive analysis of the roles of TDP-43 and FUS in RNA processing2013
- Author(s)
  2. Li, Q., Yamamoto, M., Seno, S., Matsuda, H., Suzuki, Y., Kawahara Y.
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] PAR-CLIP法を用いたTDP-43とFUSに共通するターゲットの同定2013
- Author(s)
  山本　宗隆、李　全、鈴木　穣、河原　行郎
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] small RNAs2013
- Author(s)
  KAWAHARA Yukio
- Organizer
  第７回日仏先端シンポジウム
- Place of Presentation
  ロイヤルオークホテル (滋賀)
- Year and Date
  2013-01-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-23112712
[Presentation] Comprehensive analysis of the roles of TDP-43 and FUS in RNA processing2013
- Author(s)
  Li, Q., Yamamoto, M., Seno, S., Matsuda, H., Suzuki, Y., Kawahara Y
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25670419
[Presentation] Small RNAs2013
- Author(s)
  Kawahara Y.
- Organizer
  The 7thJapanese-French Frontiers of Science Symposium
- Place of Presentation
  Shiga, Japan
- Data Source
  KAKENHI-PROJECT-23659453
[Presentation] Small RNAs2013
- Author(s)
  Kawahara Y
- Organizer
  The 7th Japanese-French Frontiers of Science Symposium
- Place of Presentation
  Shiga, Japan
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] A common RNA targets of TDP-43 and FUS: an investigation into the disease mechanism of ALS.2013
- Author(s)
  Yamamoto M, Li Q, Seno S, Matsuda H, Suzuki Y, Kawahara Y.
- Organizer
  International Symposium on Genome Science
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2013-01-09
- Data Source
  KAKENHI-PROJECT-23659453
[Presentation] Toward a comprehensive functional analysis of Ataxin-2 for the understanding of a common mechanism underlying neurodegeneration2013
- Author(s)
  Kawahara, Y
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] TDP-43 promotes neurite outgrowth through the regulation of microRNA biogenesis2012
- Author(s)
  Kawahara Y
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] TDP-43 promotes neurite outgrowth through the regulation of microRNA biogenesis.2012
- Author(s)
  Kawahara Y.
- Organizer
  The 35thAnnual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-23659453
[Presentation] A message from TDP-43/FUS complexes: narrow down the ALS-associated RNA targets2012
- Author(s)
  Li Q, Suzuki Y, Kawahara Y
- Organizer
  NGS 現場の会第二回研究会
- Place of Presentation
  大阪
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-23659453
[Presentation] ALS関連蛋白質TDP-43は転写後のマイクロRNA生成を促進する2012
- Author(s)
  河原行郎, 佐藤愛
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] Implication of microRNA dysfunction in the pathogenesis of ALS.2010
- Author(s)
  河原行郎
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] Implication of microRNA dysfunction in the pathogenesis of ALS.2010
- Author(s)
  河原行郎
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PUBLICLY-21112515
[Presentation] ALS関連蛋白質TDP-43は転写後のマイクロRNA生成を促進する
- Author(s)
  河原　行郎
- Organizer
  第５３回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム (東京)
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.
- Author(s)
  Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., *Kawahara, Y
- Organizer
  Joint Australia and Japan RNA Meeting 2014
- Place of Presentation
  Sydney, Australia
- Year and Date
  2014-11-02 – 2014-11-05
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] TDP-43 promotes neurite outgrowth through the regulation of microRNA biogenesis
- Author(s)
  KAWAHARA Yukio
- Organizer
  第３５回日本神経科学学会大会
- Place of Presentation
  名古屋国際会議場 (愛知)
- Invited
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] 神経変性疾患に関連するTDP-43の断片化機構とその生理的意義について
- Author(s)
  河原　行郎
- Organizer
  第5回神経科学と構造生物学の融合研究会
- Place of Presentation
  吹田　大阪
- Year and Date
  2014-12-04 – 2014-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-25670419
[Presentation] 神経変性疾患関連タンパク質Ataxin-2によるmRNA安定化機構の解明
- Author(s)
  余越　萌、李　全、山本　宗隆、河原　行郎
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  名古屋　愛知
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.
- Author(s)
  Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., Kawahara, Y
- Organizer
  EMBL Symposium “Complex Life of mRNA”
- Place of Presentation
  Heidelberg, Germany
- Year and Date
  2014-10-05 – 2014-10-08
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] Ataxin-2 stabilizes mRNA through the direct binding to the distinct motifs in 3’UTRs.
- Author(s)
  Yamamoto, M., Yokoshi, M., Li, Q., Okada, H., Suzuki, Y., Kawahara, Y
- Organizer
  NCI Symposium “RNA Biology 2015”
- Place of Presentation
  Bethesda, MA, USA
- Year and Date
  2015-03-11 – 2015-03-12
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] 複数の神経変性疾患に関与するAtaxin-2の生理的・病理的役割について
- Author(s)
  余越　萌、李　全、山本　宗隆、河原　行郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜　神奈川
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25293201
[Presentation] 複数の神経変性疾患に関与するAtaxin-2の生理的・病理的役割について
- Author(s)
  余越　萌、李　全、山本　宗隆、河原　行郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜　神奈川
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.
- Author(s)
  Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., *Kawahara, Y
- Organizer
  Joint Australia and Japan RNA Meeting 2014
- Place of Presentation
  Sydney, Australia
- Year and Date
  2014-11-02 – 2014-11-05
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] Ataxin-2 stabilizes mRNA through the direct binding to the distinct motifs in 3’UTRs.
- Author(s)
  Yamamoto, M., Yokoshi, M., Li, Q., Okada, H., Suzuki, Y., Kawahara, Y
- Organizer
  NCI Symposium “RNA Biology 2015”
- Place of Presentation
  Bethesda, MA, USA
- Year and Date
  2015-03-11 – 2015-03-12
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] small RNAs
- Author(s)
  KAWAHARA Yukio
- Organizer
  第７回日仏先端シンポジウム
- Place of Presentation
  ロイヤルオークホテル (滋賀)
- Invited
- Data Source
  KAKENHI-PROJECT-22390176
[Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.
- Author(s)
  Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., Kawahara, Y
- Organizer
  EMBL Symposium “Complex Life of mRNA”
- Place of Presentation
  Heidelberg, Germany
- Year and Date
  2014-10-05 – 2014-10-08
- Data Source
  KAKENHI-PUBLICLY-25110719
[Presentation] small RNAs
- Author(s)
  KAWAHARA Yukio
- Organizer
  第７回日仏先端シンポジウム
- Place of Presentation
  ロイヤルオークホテル (滋賀)
- Invited
- Data Source
  KAKENHI-PROJECT-23659453
[Presentation] 神経変性疾患関連タンパク質Ataxin-2によるmRNA安定化機構の解明
- Author(s)
  余越　萌、李　全、山本　宗隆、河原　行郎
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  名古屋　愛知
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25293201

1. 加藤有己 (10511280)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. 佐藤健吾 (20365472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SAKATA YASUHIKO (90379206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MISHIMA Masaki (70346310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 宮田敏 (60360343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 杉村宏一郎 (60375079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三浦正暢 (70647677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田岡万悟 (60271160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤原俊伸 (80362804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鈴木勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawahara Yukio 河原 行郎

KAWAHARA Yukio 河原 行郎

Research Projects

Research Products

Co-Researchers

RNA編集不全に起因する自己免疫性脳症発症メカニムズの解明Principal Investigator

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修飾塩基を含むRNAの二次構造解析技術の確立

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RNA編集酵素ADAR1の脳特異的機能の解明Principal Investigator

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Establishment of the mothod for RNA labelling in a neuron subtype-specific manner in vivoPrincipal Investigator

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RNA secondary structure prediction using nanopore sequencers

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Establishment of the mothod to quantify methylation efficiency at a specific sitePrincipal Investigator

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Eluciadation of the mechanism underlying selective neuronal death mediated by dysregulation of RNA-binding proteinsPrincipal Investigator

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Exploration for microRNAs to predict prognosis in ishemic heart failure

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非コードRNAとの結合を介したMediator複合体による転写制御機構の解明Principal Investigator

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Structural basis of transcriptional repression by SRA, a long non-coding RNA

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ALSと脊髄小脳変性症に共通した発症病態の解明Principal Investigator

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Elucidation of Ataxin-2-mediated neurodegenerationPrincipal Investigator

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The biological significance of the cleavage of ALS-associated protein TDP-43Principal Investigator

Principal Investigator

Project Period (FY)

Kawahara Yukio 河原行郎

KAWAHARA Yukio 河原行郎