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Kawahara Yukio  河原 行郎

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KAWAHARA Yukio  河原 行郎

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Researcher Number 80542563
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2021 – 2025: 大阪大学, 大学院医学系研究科, 教授
2016 – 2021: 大阪大学, 医学系研究科, 教授
2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 教授
2012 – 2013: 大阪大学, 医学(系)研究科(研究院), 准教授
2012: 大阪大学, 大学院・医学系研究科, 特任准教授 (常勤)
2011: 大阪大学, 医学(系)研究科(研究院), 特任准教授(常勤)
2009 – 2011: Osaka University, 医学系研究科, 特任准教授(常勤)
Review Section/Research Field
Principal Investigator
Neurology / Biological Sciences / Transformative Research Areas, Section (III) / Basic Section 46010:Neuroscience-general-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Medium-sized Section 51:Brain sciences and related fields / Molecular and Genome biology and related fields
Except Principal Investigator
Basic Section 62010:Life, health and medical informatics-related / Structural biochemistry / Cardiovascular medicine
Keywords
Principal Investigator
遺伝子 / 脳神経疾患 / RNA / 痴呆 / 筋萎縮性側索硬化症 / 神経変性疾患 / ALS / 脳・神経 / RNA修飾 / 細胞死 … More / RNA結合タンパク質 / 脊髄小脳変性症 / 神経分子病態学 / 細胞・組織 / 神経科学 / 核酸 / 核酸プローブ / 蛍光核酸類縁体 / ZBP1 / ADAR1 / Z型RNA / 自然免疫 / エカルディ・グティエール症候群 / RNA編集 / 発生・分化 / 疾患モデルマウス / 神経細胞 / TU tagging / 中枢神経 / マウス / RNAラベリング / 遺伝子発現 / 肥満 / ガン / エピトランスクリプトーム / メチル化 / m6A / 脳神経組織 / RNA代謝 / 子宮筋腫 / 精神遅滞 / 非コードRNA / 転写 / アポトーシス / ネクローシス / 前頭側頭葉変性症 / カスパーゼ / ウイルス / 転写後修飾 / 糖尿病 … More
Except Principal Investigator
深層学習 / RNA修飾 / ナノポアシークエンサー / RNA二次構造 / バイオインフォマティクス / ncRNA / CLIP法 / ノンコーディングRNA / Xist / RBM15 / NMR / XIST / SRA / SHARP / lncRNA / メタボロミクス / マイクロRNA / 虚血性心不全 Less
  • Research Projects

    (21 results)
  • Research Products

    (165 results)
  • Co-Researchers

    (13 People)
  •  Integrated understanding of RNA-induced perturbations in living systems and their adaptive mechanismsArea Organizer

    • Area Organizer
      河原 行郎
    • Project Period (FY)
      2025 – 2029
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
  •  攪乱RNA学創成領域の総括班活動Principal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2025 – 2029
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Osaka
  •  免疫サーベランスをすり抜ける攪乱RNAの修飾トポロジーの解明Principal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2025 – 2029
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Osaka
  •  Development of a method to visualize the formation and dynamics of left-handed RNAs in living cellsPrincipal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Osaka University
  •  Elucidating the pathological mechanisms underlying dysregulation of RNA editing-induced autoimmune-mediated encephalopathyPrincipal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Osaka University
  •  修飾塩基を含むRNAの二次構造解析技術の確立

    • Principal Investigator
      佐藤 健吾
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Tokyo Denki University
  •  Investigation of bain-specific roles of ADAR1Principal Investigator

    • Principal Investigator
      Kawahara Yukio
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Osaka University
  •  Establishment of the mothod for RNA labelling in a neuron subtype-specific manner in vivoPrincipal Investigator

    • Principal Investigator
      Kawahara Yukio
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 51:Brain sciences and related fields
    • Research Institution
      Osaka University
  •  RNA secondary structure prediction using nanopore sequencers

    • Principal Investigator
      Sato Kengo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Tokyo Denki University
      Keio University
  •  Establishment of the mothod to quantify methylation efficiency at a specific sitePrincipal Investigator

    • Principal Investigator
      Kawahara Yukio
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Molecular and Genome biology and related fields
    • Research Institution
      Osaka University
  •  Eluciadation of the mechanism underlying selective neuronal death mediated by dysregulation of RNA-binding proteinsPrincipal Investigator

    • Principal Investigator
      Kawahara Yukio
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Osaka University
  •  Exploration for microRNAs to predict prognosis in ishemic heart failure

    • Principal Investigator
      SAKATA YASUHIKO
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Tohoku University
  •  非コードRNAとの結合を介したMediator複合体による転写制御機構の解明Principal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Structural basis of transcriptional repression by SRA, a long non-coding RNA

    • Principal Investigator
      MISHIMA Masaki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokyo Metropolitan University
  •  ALSと脊髄小脳変性症に共通した発症病態の解明Principal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Elucidation of Ataxin-2-mediated neurodegenerationPrincipal Investigator

    • Principal Investigator
      Kawahara Yukio
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Osaka University
  •  The biological significance of the cleavage of ALS-associated protein TDP-43Principal Investigator

    • Principal Investigator
      KAWAHARA Yukio
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Osaka University
  •  ALSの病態解明に向けたRNA結合蛋白質TDP-43及びFUSの網羅的機能解析Principal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Challenge for the identification of ALS-related virusesPrincipal Investigator

    • Principal Investigator
      KAWAHARA Yukio
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Osaka University
  •  Elucidation of the role of TDP-43 in microRNA biogenesis and ALS pathogenesisPrincipal Investigator

    • Principal Investigator
      KAWAHARA Yukio
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Osaka University
  •  アミノ酸配列の置換を生じるRNA編集の生理的意義の解明Principal Investigator

    • Principal Investigator
      河原 行郎
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] Post-transcriptional gene regulation: RNA processing in eukaryotes.2013

    • Author(s)
      2. Valente, L., Kawahara, Y., Zinshteyn, B., Iizasa, H., Nishikura, K.
    • Total Pages
      42
    • Publisher
      Wiley-VCH book
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Book] Post-transcriptional gene regulation2011

    • Author(s)
      ルイスバレンチ、河原行郎
    • Publisher
      Wiley-VCH book社(印刷中)
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Book] Post-transcriptional gene regulation2011

    • Author(s)
      ルイスバレンチ、河原行郎
    • Publisher
      Wiley-VCH book社(印刷中)
    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Book] Post-transcriptional gene regulation2010

    • Author(s)
      ルイスバレンチ、河原行郎
    • Publisher
      Wiley-VCH book社(印刷中)
    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Journal Article] A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth2023

    • Author(s)
      Miyake Kotaro、Costa Cruz Pedro Henrique、Nagatomo Izumi、Kato Yuki、Motooka Daisuke、Satoh Shingo、Adachi Yuichi、Takeda Yoshito、Kawahara Yukio、Kumanogoh Atsushi
    • Journal Title

      Cell Reports

      Volume: 42 Issue: 7 Pages: 112688-112688

    • DOI

      10.1016/j.celrep.2023.112688

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K12109, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-23K27267
  • [Journal Article] RNA編集を応用した疾患治療の展望2023

    • Author(s)
      河原 行郎
    • Journal Title

      Clinical Neuroscience

      Volume: 41(5) Pages: 684-686

    • Data Source
      KAKENHI-PROJECT-23K27267
  • [Journal Article] RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing2023

    • Author(s)
      Xing Yanfang、Nakahama Taisuke、Wu Yuke、Inoue Maal、Kim Jung In、Todo Hiroyuki、Shibuya Toshiharu、Kato Yuki、Kawahara Yukio
    • Journal Title

      Journal of Biological Chemistry

      Volume: 299 Issue: 7 Pages: 104840-104840

    • DOI

      10.1016/j.jbc.2023.104840

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K12109, KAKENHI-PROJECT-21K07080, KAKENHI-PROJECT-23K27267
  • [Journal Article] The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways2022

    • Author(s)
      Nakahama Taisuke、Kawahara Yukio
    • Journal Title

      International Immunology

      Volume: 35 Issue: 3 Pages: 123-133

    • DOI

      10.1093/intimm/dxac056

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07080, KAKENHI-PROJECT-20H03341
  • [Journal Article] 左巻きRNAを認識する自然免疫機構2022

    • Author(s)
      河原行郎
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 78(1) Pages: 111-117

    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] RNAのイノシン化修飾の破綻はエカルディ・グティエール症候群様症状を引き起こす2022

    • Author(s)
      中濱泰祐, 河原行郎
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 77(6) Pages: 737-743

    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] RNAの巻き方を感知する自然免疫システム2022

    • Author(s)
      中濱 泰祐、河原 行郎
    • Volume
      40
    • Pages
      544
    • DOI

      10.18958/6991-00001-0000065-00

    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] RNA制御とI型インターフェロノパシー2022

    • Author(s)
      中濱泰祐, 河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 40(15) Pages: 2505-2512

    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] RNA編集を応用した核酸医薬開発への展望2021

    • Author(s)
      河原 行郎
    • Journal Title

      実験医学(増刊)

      Volume: 39 Pages: 2772-2778

    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] An Aicardi-Goutieres Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice2021

    • Author(s)
      Inoue Maal、Nakahama Taisuke、Yamasaki Ryuichiro、Shibuya Toshiharu、Kim Jung In、Todo Hiroyuki、Xing Yanfang、Kato Yuki、Morii Eiichi、Kawahara Yukio
    • Journal Title

      The Journal of Immunology

      Volume: 207 Issue: 12 Pages: 3016-3027

    • DOI

      10.4049/jimmunol.2100526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03341, KAKENHI-PROJECT-20J11266, KAKENHI-PROJECT-18K11526, KAKENHI-PROJECT-21K07080, KAKENHI-PROJECT-21K12109
  • [Journal Article] Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutieres-syndrome-like encephalopathy2021

    • Author(s)
      Nakahama Taisuke、Kato Yuki、Shibuya Toshiharu、Inoue Maal、Kim Jung In、Vongpipatana Tuangtong、Todo Hiroyuki、Xing Yanfang、Kawahara Yukio
    • Journal Title

      Immunity

      Volume: 54 Issue: 9 Pages: 1976-1988

    • DOI

      10.1016/j.immuni.2021.08.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03341, KAKENHI-PROJECT-20J11266, KAKENHI-PROJECT-18K11526, KAKENHI-PROJECT-21K07080, KAKENHI-PROJECT-21K12109
  • [Journal Article] RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain2021

    • Author(s)
      Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
    • Journal Title

      PLoS Genetics

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22580
  • [Journal Article] Deciphering the Biological Significance of ADAR1-Z-RNA Interactions2021

    • Author(s)
      Nakahama Taisuke、Kawahara Yukio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 21 Pages: 11435-11435

    • DOI

      10.3390/ijms222111435

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03341, KAKENHI-PROJECT-21K07080
  • [Journal Article] RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain2021

    • Author(s)
      Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
    • Journal Title

      PLoS Genetics

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] エピトランスクリプトーム2020

    • Author(s)
      河原 行郎
    • Journal Title

      炎症と免疫

      Volume: 28(6) Pages: 546-550

    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Journal Article] A Comparative Analysis of ADAR Mutant Mice Reveals Site-Specific Regulation of RNA Editing2020

    • Author(s)
      Pedro Henrique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara
    • Journal Title

      RNA

      Volume: 26(4) Issue: 4 Pages: 454-469

    • DOI

      10.1261/rna.072728.119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22580, KAKENHI-PROJECT-18K15186, KAKENHI-PROJECT-18K11526
  • [Journal Article] エピトランスクリプトーム2020

    • Author(s)
      河原 行郎
    • Journal Title

      炎症と免疫

      Volume: 28(6) Pages: 546-550

    • Data Source
      KAKENHI-PROJECT-19K22580
  • [Journal Article] ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways2020

    • Author(s)
      Vongpipatana T, Nakahama T, Shibuya T, Kato Y, Kawahara Y
    • Journal Title

      The Jorunal of Immunology

      Volume: 204(8) Issue: 8 Pages: 2156-2168

    • DOI

      10.4049/jimmunol.1900929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22580, KAKENHI-PROJECT-18K15186, KAKENHI-PROJECT-18J11733, KAKENHI-PROJECT-18K11526
  • [Journal Article] Quantification of methylation efficiency at a specific N6-methyladenosine position in rRNA by using BNA probes2018

    • Author(s)
      Oshima Takuya、Ishiguro Kensuke、Suzuki Tsutomu、Kawahara Yukio
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 69 Pages: 9627-9630

    • DOI

      10.1039/c8cc03713b

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-16H05320, KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-18H05272
  • [Journal Article] ADAR1-mediated RNA editing is required for thymic self-tolerance and prevention of autoimmunity2018

    • Author(s)
      Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl Walkley and Yukio Kawahara
    • Journal Title

      EMBO Reports

      Volume: 19 Issue: 12

    • DOI

      10.15252/embr.201846303

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11526, KAKENHI-PROJECT-18K15186, KAKENHI-PROJECT-16H05320, KAKENHI-PROJECT-18J11733, KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H06279
  • [Journal Article] Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing2017

    • Author(s)
      Uemura Y, Oshima T, Yamamoto M, Reyes CJ, Costa Cruz PH, Shibuya T, Kawahara Y
    • Journal Title

      Genes to Cells

      Volume: 22(9) Issue: 9 Pages: 785-798

    • DOI

      10.1111/gtc.12512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H05320
  • [Journal Article] RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin.2017

    • Author(s)
      Gallego A, Hartasanchez DA, Braso-Vives M, Garcia-Ramallo E, Lopez-Valenzuela M, Baena N, Guitart M, Fernandez-Bellon H, Kondova I, Bontrop R, Kawahara Y, Espinosa-Parrilla Y
    • Journal Title

      Gene

      Volume: 628 Pages: 109-116

    • DOI

      10.1016/j.gene.2017.07.032

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H05320
  • [Journal Article] The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain2017

    • Author(s)
      Kanemitsu Y, Fujitani M, Fujita Y, Zhang S, Su YQ, Kawahara Y, Yamashita T
    • Journal Title

      Scientific Reports

      Volume: 7(1) Issue: 1 Pages: 1155-1155

    • DOI

      10.1038/s41598-017-01317-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19352, KAKENHI-PROJECT-16H05320
  • [Journal Article] CLIP法とその改良法によるタンパク質結合RNAの高解像度解析2016

    • Author(s)
      河原行郎
    • Journal Title

      実験医学(別冊)

      Volume: 1 Pages: 149-158

    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Journal Article] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016

    • Author(s)
      Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
    • Journal Title

      Cell Reports

      Volume: 17 Issue: 8 Pages: 2004-2014

    • DOI

      10.1016/j.celrep.2016.10.073

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01471, KAKENHI-PUBLICLY-16H01615, KAKENHI-PLANNED-25117006, KAKENHI-PROJECT-16H05320, KAKENHI-PROJECT-26292150, KAKENHI-PROJECT-15K18342, KAKENHI-PROJECT-16K07100, KAKENHI-PROJECT-25000015
  • [Journal Article] CLIP法とその改良法によるタンパク質結合RNAの高解像度解析2016

    • Author(s)
      河原行郎
    • Journal Title

      実験医学(別冊)

      Volume: 1 Pages: 149-158

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] Cross-Linking and Immunopresipitation of Nuclear RNA-Binding Proteins2015

    • Author(s)
      Li,Q., Uemura,Y., Kawahara,Y.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1262 Pages: 247-263

    • DOI

      10.1007/978-1-4939-2253-6_15

    • ISBN
      9781493922529, 9781493922536
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-14J01433, KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419
  • [Journal Article] RNA代謝異常を介した神経変性疾患の発症病態2015

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      ファルマシア

      Volume: 51(1) Pages: 37-41

    • NAID

      130007447862

    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] 自己免疫疾患とRNA編集2015

    • Author(s)
      三宅浩太郎, 中濱泰祐, 河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 33(20) Pages: 3339-3344

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] RNA代謝異常を介した神経変性疾患の発症病態2015

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      ファルマシア

      Volume: 51(1) Pages: 37-41

    • NAID

      130007447862

    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] マイクロRNA2015

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      生体の科学

      Volume: 66(5) Pages: 478-479

    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Journal Article] The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.2015

    • Author(s)
      Li, Q., Yokoshi, M., Okada, H., Kawahara, Y.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6183-6183

    • DOI

      10.1038/ncomms7183

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419
  • [Journal Article] 自己免疫疾患とRNA編集2015

    • Author(s)
      三宅浩太郎, 中濱泰祐, 河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 33(20) Pages: 3339-3344

    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Journal Article] 神経疾患をmicroRNAで診断する2015

    • Author(s)
      河原行郎
    • Journal Title

      Clinical Neuroscience

      Volume: 33(11) Pages: 1302-1304

    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Journal Article] マイクロRNA2015

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      生体の科学

      Volume: 66(5) Pages: 478-479

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] 神経疾患をmicroRNAで診断する2015

    • Author(s)
      河原行郎
    • Journal Title

      Clinical Neuroscience

      Volume: 33(11) Pages: 1302-1304

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] RNA代謝異常を介した神経変性疾患の発症病態2015

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      ファルマシア

      Volume: 51(1) Pages: 37-41

    • NAID

      130007447862

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] 神経変性疾患の発症メカニズムUp-to-Date2015

    • Author(s)
      河原行郎
    • Journal Title

      BIO Clinica

      Volume: 30(7) Pages: 705-708

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] RNA疾患研究の新展開2014

    • Author(s)
      河原行郎, 塩見美喜子
    • Journal Title

      Medical Science Digest

      Volume: 40(7) Pages: 324-325

    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] RNA疾患研究の新展開2014

    • Author(s)
      河原行郎, 塩見美喜子
    • Journal Title

      Medical Science Digest

      Volume: 40(7) Pages: 324-325

    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] RNA代謝と神経変性2014

    • Author(s)
      植村有里, 河原行郎
    • Journal Title

      Brain Medical

      Volume: 26(3) Pages: 209-215

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] RNA代謝と神経変性2014

    • Author(s)
      植村有里, 河原行郎
    • Journal Title

      Brain Medical

      Volume: 26(3) Pages: 209-215

    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる2014

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      新着論文レビュー

      Volume: e9044

    • Open Access
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.2014

    • Author(s)
      Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., and Kawahara, Y.
    • Journal Title

      Molecular cell

      Volume: 55 Issue: 2 Pages: 186-198

    • DOI

      10.1016/j.molcel.2014.05.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14J01452, KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419, KAKENHI-PROJECT-221S0002
  • [Journal Article] 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる2014

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      新着論文レビュー

      Volume: e9044

    • Open Access
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] RNA代謝と神経変性2014

    • Author(s)
      植村有里, 河原行郎
    • Journal Title

      Brain Medical

      Volume: 26(3) Pages: 209-215

    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes.2014

    • Author(s)
      Kawahara, Y
    • Journal Title

      Congenital Anomalies

      Volume: 54 Issue: 1 Pages: 12-21

    • DOI

      10.1111/cga.12043

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25110719, KAKENHI-PROJECT-25293201, KAKENHI-PROJECT-25670419
  • [Journal Article] RNA疾患研究の新展開2014

    • Author(s)
      河原行郎, 塩見美喜子
    • Journal Title

      Medical Science Digest

      Volume: 40(7) Pages: 324-325

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] 神経変性疾患関連タンパク質Ataxin-2は3’非翻訳領域にある特定の配列に直接結合することによって、mRNAの安定性を促進しタンパク質発現を増加させる2014

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      新着論文レビュー

      Volume: e9044

    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] microRNAの修飾とその機能2013

    • Author(s)
      余越 萌、河原 行郎
    • Journal Title

      実験医学(増刊)

      Volume: 31 Pages: 1124-1131

    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] microRNA の機能とその修飾.2013

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 31(7) Pages: 160-167

    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] ノンコーディングRNAと神経変性疾患2013

    • Author(s)
      河原 行郎
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 421-426

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] microRNAの修飾とその機能2013

    • Author(s)
      余越 萌、河原 行郎
    • Journal Title

      実験医学(増刊)

      Volume: 31 Pages: 1124-1131

    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] ノンコーディングRNAと神経変性疾患2013

    • Author(s)
      河原 行郎
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 421-426

    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] 筋萎縮性側索硬化症とRNA結合タンパク質2013

    • Author(s)
      河原 行郎
    • Journal Title

      領域融合レビュー

      Volume: e010 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Journal Article] 筋萎縮性側索硬化症とRNA結合タンパク質2013

    • Author(s)
      河原 行郎
    • Journal Title

      領域融合レビュー

      Volume: e010 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] microRNAの修飾とその機能2013

    • Author(s)
      余越 萌、河原 行郎
    • Journal Title

      実験医学(増刊)

      Volume: 31 Pages: 1124-1131

    • Data Source
      KAKENHI-PROJECT-25293201
  • [Journal Article] ノンコーディングRNAと神経変性疾患2013

    • Author(s)
      河原 行郎
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 421-426

    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] 筋萎縮性側索硬化症とRNA結合タンパク質2013

    • Author(s)
      河原 行郎
    • Journal Title

      領域融合レビュー

      Volume: e010 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Journal Article] microRNAの機能とその修飾2013

    • Author(s)
      余越萌, 河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 31(7) Pages: 160-167

    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes2012

    • Author(s)
      Kawahara Y and Mieda-Sato I
    • Journal Title

      Proceedings of the National Academy of Sciences U.S.A.

      Volume: 109(9) Pages: 3347-3352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction2012

    • Author(s)
      Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 427(2) Pages: 280-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes2012

    • Author(s)
      河原行郎、佐藤愛
    • Journal Title

      米国科学アカデミー紀要

      Volume: 109(9) Pages: 3347-3352

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23112712
  • [Journal Article] Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm.2012

    • Author(s)
      Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Kawahara Y, Daimon T, Kuratani T, Sawa Y
    • Journal Title

      Journal of the American Heart Association

      Volume: 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] Quantification of A-to-I editing of microRNAs using aconventional method.2012

    • Author(s)
      Kawahara Y
    • Journal Title

      Nature Protocols

      Volume: 7(7) Pages: 1426-1437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes2012

    • Author(s)
      河原行郎、佐藤愛
    • Journal Title

      米国科学アカデミー紀要

      Volume: 109(9) Pages: 3347-3352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction2012

    • Author(s)
      Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 427(2) Pages: 280-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] Quantification of A-to-I editing of microRNAs using a conventional method2012

    • Author(s)
      Kawahara Y
    • Journal Title

      Nature Protocols

      Volume: 7(7) Pages: 1426-1437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] microRNA2012

    • Author(s)
      河原行郎
    • Journal Title

      分子脳血管病

      Volume: 11(4) Pages: 431-434

    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.2012

    • Author(s)
      Kawahara Y and Mieda-Sato I.
    • Journal Title

      Proceedings of the National Academy of Sciences U. S. A

      Volume: 109(9) Pages: 3347-3352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm.2012

    • Author(s)
      Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Kawahara Y, Daimon T, Kuratani T, Sawa Y.
    • Journal Title

      Journal of the American Heart Association

      Volume: 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] Quantification of A-to-I editing of microRNAs using a conventional method.2012

    • Author(s)
      Yukio Kawahara
    • Journal Title

      Nature Protocols

      Volume: 7 Issue: 7 Pages: 1426-1437

    • DOI

      10.1038/nprot.2012.073

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11F01413, KAKENHI-PROJECT-22390176, KAKENHI-PROJECT-23659453, KAKENHI-ORGANIZER-20112001, KAKENHI-PUBLICLY-23112712
  • [Journal Article] microRNA2012

    • Author(s)
      河原 行郎
    • Journal Title

      分子 脳血管病

      Volume: 11(4) Pages: 431-434

    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] マイクロRNA2011

    • Author(s)
      河原行郎
    • Journal Title

      分子精神医学

      Volume: 11(3) Pages: 172-177

    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] マイクロRNA2011

    • Author(s)
      河原行郎
    • Journal Title

      分子精神医学

      Volume: 11(3) Pages: 172-177

    • Data Source
      KAKENHI-PUBLICLY-23112712
  • [Journal Article] マイクロ RNA2011

    • Author(s)
      河原行郎
    • Journal Title

      分子精神医学

      Volume: 11(3) Pages: 172-177

    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] RNA編集の異常と関連する疾患2010

    • Author(s)
      河原行郎
    • Journal Title

      実験医学 印刷中

    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Journal Article] RNA編集の異常と関連する疾患2010

    • Author(s)
      河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 28 Pages: 1628-1635

    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] microRNA 発現の転写後調節機構.2010

    • Author(s)
      河原行郎
    • Journal Title

      生体の科学

      Volume: 61(4) Pages: 308-314

    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] RNA 編集の異常と関連する疾患2010

    • Author(s)
      河原行郎
    • Journal Title

      実験医学(増刊)

      Volume: 28 Pages: 1628-1635

    • Data Source
      KAKENHI-PROJECT-23659453
  • [Journal Article] microRNA発現の転写後調節機構2010

    • Author(s)
      河原行郎
    • Journal Title

      生体の科学

      Volume: 61(4) Pages: 308-314

    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] microRNA発現の転写後調節機構2010

    • Author(s)
      河原行郎
    • Journal Title

      生体の科学

      Volume: 61巻 Pages: 308-314

    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Journal Article] RNA編集の異常と関連する疾患2010

    • Author(s)
      河原行郎
    • Journal Title

      実験医学

      Volume: 28巻 Pages: 1628-1635

    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Journal Article] Functional relevance of serotonin 2C receptor mRNA editing in anti-depressant- and anxiety-like behabiors.2010

    • Author(s)
      セドリック モンブリュー、河原行郎
    • Journal Title

      Neuropharmacology

      Volume: 59巻 Pages: 468-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] Functional relevance of serotonin 2C receptor mRNA editing in anti-depressant- and anxiety-like bebabiors.2010

    • Author(s)
      セドリック モンブリュー、河原行郎
    • Journal Title

      Neuropharmacology

      Volume: 59巻 Pages: 468-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Journal Article] RNA編集の異常と関連する疾患2010

    • Author(s)
      河原行郎
    • Journal Title

      実験医学

      Volume: 28巻 Pages: 1628-1635

    • Data Source
      KAKENHI-PROJECT-22390176
  • [Journal Article] RNA編集によるmiRNAの機能調節2009

    • Author(s)
      河原行郎、西倉和子
    • Journal Title

      蛋白質核酸酵素 VOL.54

      Pages: 1133-1140

    • NAID

      40016708050

    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Journal Article] RNA編集から疾患治療へ2009

    • Author(s)
      河原行郎、西倉和子
    • Journal Title

      遺伝子医学MOOK 最新RNAと疾患研究 15巻

      Pages: 174-180

    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Presentation] RNA編集による免疫恒常性維持とその破綻による脳内炎症2023

    • Author(s)
      河原 行郎
    • Organizer
      第35回日本神経免疫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K27267
  • [Presentation] 神経変性疾患研究におけるシングルセル解析の現状と課題2023

    • Author(s)
      河原 行郎
    • Organizer
      第64回日本神経病理学会総会学術研究会・第66回日本神経化学学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K27267
  • [Presentation] RNA編集酵素ADAR1による自然免疫制御の新たな展開2022

    • Author(s)
      河原 行郎
    • Organizer
      第7回日本骨免疫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Presentation] Regulatory Mechanisms underlying ADAR1 p150-mediated RNA editing2022

    • Author(s)
      Nakahama Taisuke、Kawahara Yukio
    • Organizer
      A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA 2022 fall
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Presentation] Deciphering the biological significance of ADAR1-Z-RNA interactions2021

    • Author(s)
      Yukio Kawahara
    • Organizer
      A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA 2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Presentation] RNA編集研究の最前線:基礎、病態、そして治療法への応用について2020

    • Author(s)
      河原 行郎
    • Organizer
      核酸医薬シンポジウム2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Presentation] The physiological significance of RNA editing in maintaining brain homeostasis2020

    • Author(s)
      Yuko Kawahara
    • Organizer
      第43回日本神経科学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22580
  • [Presentation] The physiological significance of RNA editing in maintaining brain homeostasis2020

    • Author(s)
      Yuko Kawahara
    • Organizer
      第43回日本神経科学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03341
  • [Presentation] RNA編集研究の最前線:基礎、病態、そして治療法への応用について2020

    • Author(s)
      河原 行郎
    • Organizer
      核酸医薬シンポジウム2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22580
  • [Presentation] Precise determination of responsible ADARs for each RNA editing site in vivo2019

    • Author(s)
      Pedro Herique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara
    • Organizer
      Gordon Research Conference & Seminar
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19352
  • [Presentation] ADAR1-mediated RNA editing is required for thymic selftolerance and inhibition of autoimmunity2019

    • Author(s)
      Nakahama T, Kato Y, Kim JI, Vongpipatana T, Suzuki Y, Walkley CR, Kawahara Y
    • Organizer
      Gordon Research Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19352
  • [Presentation] ADAR1 regulates early T cell development via MDA5-dependent and -independent pathways2019

    • Author(s)
      Tuangtong Vogpipatana, Taisuke Nakahama, Yuki Kato, Carl Walkley and Yukio Kawahara
    • Organizer
      Gordon Research Conference & Seminar
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19352
  • [Presentation] TDP-43ノックインマウスにおける神経変性病態2018

    • Author(s)
      河原 行郎
    • Organizer
      第37回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] ALS発症機構の解明に向けたTDP-43ノックインマウスの作製と解析2018

    • Author(s)
      河原 行郎
    • Organizer
      第一回 三融会・武田神経科学シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] TDP-43ノックインマウスを用いたALS発症病態の解析2018

    • Author(s)
      河原 行郎
    • Organizer
      第59回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] The role of ADAR1-mediated RNA editing in development2017

    • Author(s)
      Yukio Kawahara
    • Organizer
      ConBio2017 (2017年度) 生命科学系学会合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19352
  • [Presentation] The role of RNA editing in T cell development2017

    • Author(s)
      Yukio Kawahara
    • Organizer
      第43回内藤カンファランス
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19352
  • [Presentation] Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing2017

    • Author(s)
      Yuri Uemura, Takuya Oshima1, Munetaka Yamamoto, Charles Jourdan Reyes, Pedro Herique Costa Cruz, Toshiharu Shibuya, Yukio Kawahara
    • Organizer
      RNA2017, The 22nd annual meeting of the RNA society
    • Data Source
      KAKENHI-PROJECT-17K19352
  • [Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2017

    • Author(s)
      Nakahama T, Walkley C, Kawahara Y.
    • Organizer
      Gordon Research Conference on RNA editing
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2017-03-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2017

    • Author(s)
      Nakahama T, Walkley C, Kawahara Y.
    • Organizer
      Gordon Research Conference on RNA editing
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2017-03-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2017

    • Author(s)
      Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
    • Organizer
      Gordon Research Conference on RNA editing
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2017-03-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2017

    • Author(s)
      Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
    • Organizer
      Gordon Research Conference on RNA editing
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2017-03-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016

    • Author(s)
      河原 行郎
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2016

    • Author(s)
      Nakahama T, Walkley C, Kawahara Y.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16H05320
  • [Presentation] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016

    • Author(s)
      河原 行郎
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Presentation] RNA editing-mediated prevention of activating MDA5 pathway is required for early T cell development2016

    • Author(s)
      Nakahama T, Walkley C, Kawahara Y.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PUBLICLY-15H01471
  • [Presentation] 分泌型マイクロRNAの医療応用への期待と課題2015

    • Author(s)
      河原 行郎
    • Organizer
      第55回臨床化学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] U-rich RNA 結合タンパク質Ataxin-2 はmRNA を安定化する2015

    • Author(s)
      余越 萌, 李 全, 山本 宗隆, 岡田 ひとみ, 鈴木 穣, 河原 行郎
    • Organizer
      RNAフロンティアミーティング2015
    • Place of Presentation
      山形
    • Year and Date
      2015-12-08
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] RNA binding proteins involved in neurodegeneration2014

    • Author(s)
      Kawahara, Y
    • Organizer
      第12回日本プロテオーム学会年会
    • Place of Presentation
      筑波 茨城
    • Year and Date
      2014-06-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] Elucidation of Ataxin-2-mediated regulation of RNA metabolism2014

    • Author(s)
      Kawahara, Y
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜 神奈川
    • Year and Date
      2014-09-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] Identification of common targets of TDP-43 and FUS by PAR-CLIP.2014

    • Author(s)
      1. Li, Q., Yamamoto, M., Yokoshi, M., Suzuki, Y., Kawahara Y.,
    • Organizer
      New Frontier of Molecular Neruopathology 2014
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Presentation] Toward a comprehensive analysis of Ataxin-2 functions for the understanding of a common mechanism underlying neurodegeneration2014

    • Author(s)
      Kawahara, Y
    • Organizer
      第91回日本生理学会年会
    • Place of Presentation
      鹿児島
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Identification of common targets of TDP-43 and FUS by PAR-CLIP.2014

    • Author(s)
      1. Li, Q., Yamamoto, M., Yokoshi, M., Suzuki, Y., Kawahara Y.
    • Organizer
      New Frontier of Molecular Neruopathology 2014
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Toward a comprehensive analysis of Ataxin-2 functions for the understanding of a common mechanism underlying neurodegeneration2014

    • Author(s)
      Kawahara, Y
    • Organizer
      第91回日本生理学会年会
    • Place of Presentation
      鹿児島
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] TDP-43断片化の生理的意義について2014

    • Author(s)
      河原 行郎
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      博多 福岡
    • Year and Date
      2014-05-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Presentation] Identification of common targets of TDP-43 and FUS by PAR-CLIP.2014

    • Author(s)
      Li, Q., Yamamoto, M., Yokoshi, M., Suzuki, Y., Kawahara Y.
    • Organizer
      New Frontier of Molecular Neruopathology 2014
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] Elucidation of Ataxin-2-mediated regulation of RNA metabolism2014

    • Author(s)
      Kawahara, Y
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜 神奈川
    • Year and Date
      2014-09-11
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Ataxin-2の生理的機能とpolyQ鎖伸長の病的意義について2014

    • Author(s)
      河原 行郎
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      名古屋 愛知
    • Year and Date
      2014-07-23
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Ataxin-2の生理的機能とpolyQ鎖伸長の病的意義について2014

    • Author(s)
      河原 行郎
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      名古屋 愛知
    • Year and Date
      2014-07-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] RNA binding proteins involved in neurodegeneration2014

    • Author(s)
      Kawahara, Y
    • Organizer
      第12回日本プロテオーム学会年会
    • Place of Presentation
      筑波 茨城
    • Year and Date
      2014-06-18
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] PAR-CLIP法を用いたTDP-43とFUSに共通するターゲットの同定2013

    • Author(s)
      山本 宗隆、李 全、鈴木 穣、河原 行郎
    • Organizer
      第15回RNAミーティング
    • Place of Presentation
      愛媛
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Presentation] Comprehensive analysis of the roles of TDP-43 and FUS in RNA processing2013

    • Author(s)
      Li, Q., Yamamoto, M., Seno, S., Matsuda, H., Suzuki, Y., Kawahara Y.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] PAR-CLIP法を用いたTDP-43とFUSに共通するターゲットの同定2013

    • Author(s)
      山本 宗隆、李 全、鈴木 穣、河原 行郎
    • Organizer
      第15回RNAミーティング
    • Place of Presentation
      愛媛
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] Toward a comprehensive functional analysis of Ataxin-2 for the understanding of a common mechanism underlying neurodegeneration2013

    • Author(s)
      Kawahara, Y
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Comprehensive analysis of the roles of TDP-43 and FUS in RNA processing2013

    • Author(s)
      2. Li, Q., Yamamoto, M., Seno, S., Matsuda, H., Suzuki, Y., Kawahara Y.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] PAR-CLIP法を用いたTDP-43とFUSに共通するターゲットの同定2013

    • Author(s)
      山本 宗隆、李 全、鈴木 穣、河原 行郎
    • Organizer
      第15回RNAミーティング
    • Place of Presentation
      愛媛
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] small RNAs2013

    • Author(s)
      KAWAHARA Yukio
    • Organizer
      第7回日仏先端シンポジウム
    • Place of Presentation
      ロイヤルオークホテル (滋賀)
    • Year and Date
      2013-01-25
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23112712
  • [Presentation] Comprehensive analysis of the roles of TDP-43 and FUS in RNA processing2013

    • Author(s)
      Li, Q., Yamamoto, M., Seno, S., Matsuda, H., Suzuki, Y., Kawahara Y
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Presentation] Small RNAs2013

    • Author(s)
      Kawahara Y.
    • Organizer
      The 7thJapanese-French Frontiers of Science Symposium
    • Place of Presentation
      Shiga, Japan
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Presentation] Small RNAs2013

    • Author(s)
      Kawahara Y
    • Organizer
      The 7th Japanese-French Frontiers of Science Symposium
    • Place of Presentation
      Shiga, Japan
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] A common RNA targets of TDP-43 and FUS: an investigation into the disease mechanism of ALS.2013

    • Author(s)
      Yamamoto M, Li Q, Seno S, Matsuda H, Suzuki Y, Kawahara Y.
    • Organizer
      International Symposium on Genome Science
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2013-01-09
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Presentation] Toward a comprehensive functional analysis of Ataxin-2 for the understanding of a common mechanism underlying neurodegeneration2013

    • Author(s)
      Kawahara, Y
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] TDP-43 promotes neurite outgrowth through the regulation of microRNA biogenesis2012

    • Author(s)
      Kawahara Y
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya, Japan
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] TDP-43 promotes neurite outgrowth through the regulation of microRNA biogenesis.2012

    • Author(s)
      Kawahara Y.
    • Organizer
      The 35thAnnual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya, Japan
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Presentation] A message from TDP-43/FUS complexes: narrow down the ALS-associated RNA targets2012

    • Author(s)
      Li Q, Suzuki Y, Kawahara Y
    • Organizer
      NGS 現場の会第二回研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-25
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Presentation] ALS関連蛋白質TDP-43は転写後のマイクロRNA生成を促進する2012

    • Author(s)
      河原行郎, 佐藤愛
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-23
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] Implication of microRNA dysfunction in the pathogenesis of ALS.2010

    • Author(s)
      河原行郎
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] Implication of microRNA dysfunction in the pathogenesis of ALS.2010

    • Author(s)
      河原行郎
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PUBLICLY-21112515
  • [Presentation] ALS関連蛋白質TDP-43は転写後のマイクロRNA生成を促進する

    • Author(s)
      河原 行郎
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.

    • Author(s)
      Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., *Kawahara, Y
    • Organizer
      Joint Australia and Japan RNA Meeting 2014
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-11-02 – 2014-11-05
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] TDP-43 promotes neurite outgrowth through the regulation of microRNA biogenesis

    • Author(s)
      KAWAHARA Yukio
    • Organizer
      第35回日本神経科学学会大会
    • Place of Presentation
      名古屋国際会議場 (愛知)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] 神経変性疾患に関連するTDP-43の断片化機構とその生理的意義について

    • Author(s)
      河原 行郎
    • Organizer
      第5回神経科学と構造生物学の融合研究会
    • Place of Presentation
      吹田 大阪
    • Year and Date
      2014-12-04 – 2014-12-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670419
  • [Presentation] 神経変性疾患関連タンパク質Ataxin-2によるmRNA安定化機構の解明

    • Author(s)
      余越 萌、李 全、山本 宗隆、河原 行郎
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      名古屋 愛知
    • Year and Date
      2014-07-23 – 2014-07-25
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.

    • Author(s)
      Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., Kawahara, Y
    • Organizer
      EMBL Symposium “Complex Life of mRNA”
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2014-10-05 – 2014-10-08
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] Ataxin-2 stabilizes mRNA through the direct binding to the distinct motifs in 3’UTRs.

    • Author(s)
      Yamamoto, M., Yokoshi, M., Li, Q., Okada, H., Suzuki, Y., Kawahara, Y
    • Organizer
      NCI Symposium “RNA Biology 2015”
    • Place of Presentation
      Bethesda, MA, USA
    • Year and Date
      2015-03-11 – 2015-03-12
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] 複数の神経変性疾患に関与するAtaxin-2の生理的・病理的役割について

    • Author(s)
      余越 萌、李 全、山本 宗隆、河原 行郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜 神奈川
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25293201
  • [Presentation] 複数の神経変性疾患に関与するAtaxin-2の生理的・病理的役割について

    • Author(s)
      余越 萌、李 全、山本 宗隆、河原 行郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜 神奈川
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.

    • Author(s)
      Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., *Kawahara, Y
    • Organizer
      Joint Australia and Japan RNA Meeting 2014
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-11-02 – 2014-11-05
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] Ataxin-2 stabilizes mRNA through the direct binding to the distinct motifs in 3’UTRs.

    • Author(s)
      Yamamoto, M., Yokoshi, M., Li, Q., Okada, H., Suzuki, Y., Kawahara, Y
    • Organizer
      NCI Symposium “RNA Biology 2015”
    • Place of Presentation
      Bethesda, MA, USA
    • Year and Date
      2015-03-11 – 2015-03-12
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] small RNAs

    • Author(s)
      KAWAHARA Yukio
    • Organizer
      第7回日仏先端シンポジウム
    • Place of Presentation
      ロイヤルオークホテル (滋賀)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390176
  • [Presentation] Ataxin-2 promotes the stability of mRNA through the direct binding to the distinct motifs.

    • Author(s)
      Yokoshi, M., Li, Q., Yamamoto, M., Okada, H., Suzuki, Y., Kawahara, Y
    • Organizer
      EMBL Symposium “Complex Life of mRNA”
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2014-10-05 – 2014-10-08
    • Data Source
      KAKENHI-PUBLICLY-25110719
  • [Presentation] small RNAs

    • Author(s)
      KAWAHARA Yukio
    • Organizer
      第7回日仏先端シンポジウム
    • Place of Presentation
      ロイヤルオークホテル (滋賀)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659453
  • [Presentation] 神経変性疾患関連タンパク質Ataxin-2によるmRNA安定化機構の解明

    • Author(s)
      余越 萌、李 全、山本 宗隆、河原 行郎
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      名古屋 愛知
    • Year and Date
      2014-07-23 – 2014-07-25
    • Data Source
      KAKENHI-PROJECT-25293201
  • 1.  加藤 有己 (10511280)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 9 results
  • 2.  Sato Kengo (20365472)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  SAKATA YASUHIKO (90379206)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MISHIMA Masaki (70346310)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  宮田 敏 (60360343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  杉村 宏一郎 (60375079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  三浦 正暢 (70647677)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  田岡 万悟 (60271160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  藤原 俊伸 (80362804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  鈴木 穣 (40323646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  朴 昭映 (10628556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  中濱 泰祐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  鈴木 勉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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