Iwahori Kota 岩堀幸太

… Alternative Names

IWAHORI KOTA 岩堀幸太

IWAHORI Kota 岩堀幸太

Less

Researcher Number	80566448
Other IDs	https://orcid.org/0000-0002-9891-6003
Affiliation (Current)	2025: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 研究所がん免疫療法開発部部長 2025: 独立行政法人国立病院機構大阪刀根山医療センター(臨床研究部), 独立行政法人国立病院機構大阪刀根山医療センター, 研究員(移行)
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 特任講師(常勤) 2016 – 2021: 大阪大学, 医学系研究科, 特任講師(常勤) 2015: 大阪大学, 医学(系)研究科(研究院), 特任講師(常勤) 2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 2010: 独立行政法人医薬基盤研究所, 創薬基盤研究部・免疫シグナルプロジェクト, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator がん免疫療法 / Tリンパ球 / 肺がん / リキッドバイオプシー / 肺癌 / PD-1 / コンパニオン診断薬 / T細胞 / BiTE / SOCS(Suppressor of cytokine signaling) / SOCS / 遺伝子治療 / 悪性胸膜中皮腫 … More Except Principal Investigator … More 骨髄由来抑制細胞 / 免疫チェックポイント / T細胞疲弊 / 腫瘍浸潤T細胞 / ImmunoScore / ImmunoGram / TAM / Treg / MDSC / 効果T細胞 / 制御性T細胞 / 免疫抑制因子 / 腫瘍組織浸潤効果T細胞 / 腫瘍内浸潤免疫担当細胞 / 免疫チェックポイント阻害剤 / RNAシークエンス / 多重蛍光免疫組織化学染色 / フローサイトメトリー / 腫瘍内浸潤免疫細胞 / 癌 / がん Less

T細胞抑制分子を標的とした新規がん免疫療法の開発Principal Investigator
- Principal Investigator
  
  岩堀幸太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka University
Development of T-cell immunotherapy for cancer and viral diseasePrincipal Investigator
- Principal Investigator
  
  Iwahori Kota
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka University
Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunity
- Principal Investigator
  
  Wada Hisashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Development of companion diagnostics for cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Iwahori Kota
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka University
Development of Engager T cells for immunotherapy of lung cancerPrincipal Investigator
- Principal Investigator
  
  IWAHORI KOTA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University
Development of SOCS gene therapy for malignant pleural mesotheliomaPrincipal Investigator
- Principal Investigator
  
  IWAHORI Kota
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  独立行政法人医薬基盤研究所

All 2023 2022 2021 2020 2019 2018 2017 2011 2010 Other

All Journal Article Presentation

[Journal Article] A randomized phase 2 study on demeclocycline in patients with mild-to-moderate COVID-192023
- Author(s)
  Iwahori Kota、Nii Takuro、Yamaguchi Norihiko、Kawasaki Takahiro、Okamura Satomi、Hashimoto Kazuki、Matsuki Takanori、Tsujino Kazuyuki、Miki Keisuke、Osa Akio、Goya Sho、Abe Kinya、Mori Masahide、Takeda Yoshito、Yamada Tomomi、Kida Hiroshi、Kumanogoh Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-41051-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08153
[Journal Article] Impact of minocycline on outcomes of EGFR-mutant non-small cell lung cancer patients treated with EGFR-TKIs2023
- Author(s)
  Tone Mari、Iwahori Kota、Shiroyama Takayuki、Futami Shinji、Naito Yujiro、Fukushima Kiyoharu、Miyake Kotaro、Koyama Shohei、Hirata Haruhiko、Nagatomo Izumi、Wada Hisashi、Takeda Yoshito、Kumanogoh Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-35519-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08153
[Journal Article] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer2022
- Author(s)
  Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura and Hisashi Wada
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-022-09458-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Tumor-infiltrating ICOS+ Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and ‘Hot’ Tumor2022
- Author(s)
  HITOMI KAJIKAWA, MICHINARI HIRATA, MIYA HARUNA, AZUMI UEYAMA, KATSUTOSHI HIROSE, ATSUNARI KAWASHIMA, KOTA IWAHORI, KAZUHIDE MATSUNAGA, SATORU TOYOSAWA, NARIKAZU UZAWA and HISASHI WADA
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 5 Pages: 2383-2393
- DOI
  10.21873/anticanres.15717
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Tetracyclines Enhance Anti-tumor T-Cell Responses Induced by a Bispecific T-Cell Engager2022
- Author(s)
  Noguchi Yuki、Yamamoto Yoko、Iwahori Kota、Matsumoto Mitsunobu、Hirata Michinari、Okuyama Hiroomi、Shintani Yasushi、Kumanogoh Atsushi、Wada Hisashi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 4 Pages: 429-437
- DOI
  10.1248/bpb.b21-00806
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08153
[Journal Article] The impact of ICOS+ regulatory T cells and Helicobacter pylori infection on the prognosis of patients with gastric and colorectal cancer: potential prognostic benefit of pre-operative eradication therapy2021
- Author(s)
  Urakawa Shinya、Yamasaki Makoto、Makino Tomoki、Kurokawa Yukinori、Yamamoto Kei、Goto Kumiko、Haruna Miya、Hirata Michinari、Morimoto-Okazawa Akiko、Kawashima Atsunari、Iwahori Kota、Mizushima Tsunekazu、Sato Eiichi、Mori Masaki、Doki Yuichiro、Wada Hisashi
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 70 Issue: 2 Pages: 443-452
- DOI
  10.1007/s00262-020-02696-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors2020
- Author(s)
  Yoko Yamamoto, Kota Iwahori, Soichiro Funaki, Mitsunobu Matsumoto, Michinari Hirata, Tetsuya Yoshida, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Masato Minami, Eiichi Sato, Atsushi Kumanogoh, Yasushi Shintani, Meinoshin Okumura, Hisashi Wada
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 4064-4064
- DOI
  10.1038/s41598-020-61053-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-18K16419, KAKENHI-PROJECT-18K08143
[Journal Article] Tumour Grade Significantly Correlates With Total Dysfunction of Tumour Tissue-Infiltrating Lymphocytes in Renal Cell Carcinoma2020
- Author(s)
  Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Nishida K, Nojima S, Yamamoto Y, Kato T, Hatano K, Ujike T, Nagahara A, Fujita K, Morimoto-Okazawa A, Iwahori K, Uemura M, Imamura R, Ohkura N, Morii E, Sakaguchi S, Wada H, Nonomura N.
- Journal Title
  
  Sci Rep .
  
  Volume: 10 Issue: 1 Pages: 6220-6220
- DOI
  10.1038/s41598-020-63060-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-17K19555, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-19K16557
[Journal Article] Cytotoxic CD8+ Lymphocytes in the Tumor Microenvironment2020
- Author(s)
  Iwahori Kota
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 1224 Pages: 53-62
- DOI
  10.1007/978-3-030-35723-8_4
- ISBN
  9783030357221, 9783030357238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08143
[Journal Article] Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer2020
- Author(s)
  Haruna Miya、Hirata Michinari、Iwahori Kota、Kanazawa Takayuki、Yamamoto Yoko、Goto Kumiko、Kawashima Atsunari、Morimoto-Okazawa Akiko、Funaki Soichiro、Shintani Yasushi、Kumanogoh Atsushi、Wada Hisashi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 3 Pages: 399-403
- DOI
  10.1248/bpb.b19-00702
- NAID
  130007804428
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Clinical importance of the expression of CD4+CD8+ T cells in Renal Cell Carcinoma.2020
- Author(s)
  Nishida K, Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Yamamoto K, Yamamoto Y, Sawada M, Kato R, Kato T, Hatano K, Ujike T, Fujita K, Uemura M, Morimoto-Okazawa A, Iwahori K, Yamasaki M, Ohkura N, Sakaguchi S, Nonomura N, Doki Y, Wada H.
- Journal Title
  
  Int Immunol
  
  Volume: Jan24 Issue: 5 Pages: 347-357
- DOI
  10.1093/intimm/dxaa004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-16H06295
[Journal Article] PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer2020
- Author(s)
  Sawada Masaaki、Goto Kumiko、Morimoto-Okazawa Akiko、Haruna Miya、Yamamoto Kei、Yamamoto Yoko、Nakagawa Satoshi、Hiramatsu Kosuke、Matsuzaki Shinya、Kobayashi Eiji、Kawashima Atsunari、Hirata Michinari、Iwahori Kota、Kimura Toshihiro、Ueda Yutaka、Kimura Tadashi、Wada Hisashi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 6 Pages: 397-405
- DOI
  10.1093/intimm/dxaa010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Peri-operative monocyte count is a marker of poor prognosis in gastric cancer: increased monocytes are a characteristic of myeloid-derived suppressor cells.2019
- Author(s)
  Shinya Urakawa, Makoto Yamasaki, Kumiko Goto, Miya Haruna, Michinari Hirata, Akiko Morimoto-Okazawa, Atsunari Kawashima, Kota Iwahori, Tomoki Makino, Yukinori Kurokawa, Tomomi Yamada, Masaki Mori, Yuichiro Doki, Hisashi Wada.
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 68 Issue: 8 Pages: 1341-1350
- DOI
  10.1007/s00262-019-02366-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03729
[Journal Article] Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment2019
- Author(s)
  Iwahori Kota、Shintani Yasushi、Funaki Soichiro、Yamamoto Yoko、Matsumoto Mitsunobu、Yoshida Tetsuya、Morimoto-Okazawa Akiko、Kawashima Atsunari、Sato Eiichi、Gottschalk Stephen、Okumura Meinoshin、Kumanogoh Atsushi、Wada Hisashi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2636-2636
- DOI
  10.1038/s41598-019-39345-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08143, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-19H03745
[Journal Article] Phenotypic Analysis of Tumor Tissue?Infiltrating Lymphocytes in Tumor Microenvironment of Bladder Cancer and Upper Urinary Tract Carcinoma2019
- Author(s)
  Kawashima Atsunari、Kanazawa Takayuki、Jingushi Kentaro、Kato Taigo、Ujike Takeshi、Nagahara Akira、Fujita Kazutoshi、Morimoto-Okazawa Akiko、Iwahori Kota、Uemura Motohide、Imamura Ryoichi、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Clinical Genitourinary Cancer
  
  Volume: 17 Issue: 2 Pages: 114-124
- DOI
  10.1016/j.clgc.2018.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16790, KAKENHI-PROJECT-19H03729
[Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma2011
- Author(s)
  Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T
- Journal Title
  
  Int J Cancer
  
  Volume: 129(4) Issue: 4 Pages: 993-1005
- DOI
  10.1002/ijc.25716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101, KAKENHI-PROJECT-22790775
[Journal Article] Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells2011
- Author(s)
  Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T
- Journal Title
  
  Int J Cancer
  
  Volume: (in press) Issue: 6 Pages: 1287-96
- DOI
  10.1002/ijc.27350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101, KAKENHI-PROJECT-22790775
[Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma
- Author(s)
  Iwahori K, et al.
- Journal Title
  
  International Journal of Cancer
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790775
[Presentation] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer2022
- Author(s)
  Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura and Hisashi Wada
- Organizer
  JSMO2022
- Data Source
  KAKENHI-PROJECT-19H03729
[Presentation] 末梢血T細胞活性測定による腫瘍免疫効果予測2018
- Author(s)
  岩堀幸太、新谷康、舟木壮一郎、山本陽子、奥村明之進、熊ノ郷淳
- Organizer
  第59回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08143
[Presentation] 肺癌組織における免疫プロファイリング2017
- Author(s)
  岩堀幸太、新谷康、舟木壮一郎、松本光史、後藤久充子、金沢崇之、奥村明之進、熊ノ郷淳、和田尚
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09218
[Presentation] SOCS1 gene delivery, in combination with pemetrexed and cisplatin treatment, enhances therapeutic efficacy in malignant mesothelioma2011
- Author(s)
  Kota Iwahori, Satoshi Serada, Minoru Fujimoto, Hiroyuki Mizuguchi, Tetsuji Naka
- Organizer
  第17回日本遺伝子治療学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-22790775
[Presentation] SOCS-3 protein exhibits activity in malignant pleural mesothelioma2010
- Author(s)
  Iwahori K, Serada S, Shimada K, Suzuki H, Hirashima T, Kawase I, Naka T
- Organizer
  The 10th International Conference of the International Mesothelioma Interest Group
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22790775
[Presentation] SOCS-3 protein exhibits preclinical anti-tumor activity in malignant pleural mesothelioma2010
- Author(s)
  Iwahori K, et al.
- Organizer
  The 10th International Conference of the International Mesothelioma Interrest Group
- Place of Presentation
  京都
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22790775

1. Wada Hisashi (70243459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 佐藤永一 (60408101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 垣見和宏 (80273358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 牧野知紀 (80528620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 森本晶子 (60601193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 藤本穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 森井英一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 河嶋厚成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iwahori Kota 岩堀 幸太

IWAHORI KOTA 岩堀 幸太

IWAHORI Kota 岩堀 幸太

Research Projects

Research Products

Co-Researchers

T細胞抑制分子を標的とした新規がん免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of T-cell immunotherapy for cancer and viral diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of companion diagnostics for cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Engager T cells for immunotherapy of lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of SOCS gene therapy for malignant pleural mesotheliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A randomized phase 2 study on demeclocycline in patients with mild-to-moderate COVID-192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of minocycline on outcomes of EGFR-mutant non-small cell lung cancer patients treated with EGFR-TKIs2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-infiltrating ICOS+ Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and ‘Hot’ Tumor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tetracyclines Enhance Anti-tumor T-Cell Responses Induced by a Bispecific T-Cell Engager2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The impact of ICOS+ regulatory T cells and Helicobacter pylori infection on the prognosis of patients with gastric and colorectal cancer: potential prognostic benefit of pre-operative eradication therapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors2020

Author(s)

Journal Title

DOI

Data Source

Iwahori Kota 岩堀幸太

IWAHORI KOTA 岩堀幸太

IWAHORI Kota 岩堀幸太