Kina Mika 喜名美香

Researcher Number	80578914
Other IDs
Affiliation (Current)	2025: 群馬大学, 医学部附属病院, 医員 2025: 琉球大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 群馬大学, 医学部附属病院, 医員 2015 – 2018: 琉球大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Eating habits Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator BMI / 組織学的分化度 / 口腔癌 / 内臓脂肪型肥満 / 口腔扁平上皮癌 / 内臓肥満 / PPAR-γ / 腫瘍微小環境 / 抗がん剤感受性 / nitrate / メタボリックシンドローム … More Except Principal Investigator … More 口腔癌 / メトロノーム化学療法 / 抗癌剤耐性 / EphA4 / 高分化型腫瘍 / 頭頸部癌 / 術前メトロノーム化学療法 / 術前化学療法 / 分子生学的メカニズム / 高分化型口腔癌 / 抗がん剤 / チロシンリン酸化 / 高分化型 Less

口腔癌と内臓脂肪型肥満の間に生じる組織学的分化度依存的なネットワークの解明Principal Investigator
- Principal Investigator
  
  喜名美香
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Gunma University
Investigation of the mechanism for metronomic chemotherapy resistance in well-differentiated oral cancer driven by EphA4 activation
- Principal Investigator
  
  Kina Shinichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Gunma University
Elucidation of the mechanism of chemotherapy resistance relating the obese signaling pathwayPrincipal Investigator
- Principal Investigator
  
  Kina Mika
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Gunma University
Clarification of molecular biological mechanism targeting EphA4 against the anticancer drug resistance well-differentiated oral squamous cell carcinoma
- Principal Investigator
  
  Nakasone Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of the Ryukyus
Construction of new therapy method that targets EphA4 which is activated by chemotherapeutic reagents
- Principal Investigator
  
  Kina Shinichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Gunma University
  University of the Ryukyus
Elucidation of the molecular mechanism of the metabolic syndrome induced by long-term dietary nitrite and nitrate deficiency and development of the new treatmentPrincipal Investigator
- Principal Investigator
  
  Kina Mika
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Eating habits
- Research Institution
  University of the Ryukyus

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Higher overall survival rates of oral squamous cell carcinoma treated with metronomic neoadjuvant chemotherapy2024
- Author(s)
  Shinichiro Kina , Sho Miyamoto , Reika Kawabata-Iwakawa , Mika Kina-Tanada , Masaru Ogawa , Satoshi Yokoo
- Journal Title
  
  American Journal of Cancer Research
  
  Volume: 14 Issue: 3 Pages: 1033-1051
- DOI
  10.62347/eynt8387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16141, KAKENHI-PROJECT-21K10084
[Journal Article] EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity2023
- Author(s)
  Kina Shinichiro、Kawabata-Iwakawa Reika、Miyamoto Sho、Kato Tomoki、Kina-Tanada Mika、Arasaki Akira
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 945 Pages: 175611-175611
- DOI
  10.1016/j.ejphar.2023.175611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-19K19171
[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy2023
- Author(s)
  Miyamoto Sho、Hirohashi Yoshihiko、Morita Rena、Miyazaki Akihiro、Ogi Kazuhiro、Kanaseki Takayuki、Ide Kentaro、Shirakawa Jumpei、Tsukahara Tomohide、Murai Aiko、Sasaya Takashi、Koike Kazushige、Kina Shinichiro、Kawano Toshihiro、Goto Takahiro、Ntege Edward Hosea、Shimizu Yusuke、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 9 Pages: 3496-3508
- DOI
  10.1111/cas.15873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-23K27794
[Journal Article] Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis2022
- Author(s)
  Sugisawa Akiyuki、Toyoda Zensei、Tanabe Yasuka、Uehara Karina、Oshiro Aya、Yamazato Reo、Sakamoto Chiharu、Yogi Shohei、Kurima Kiyoto、Kina Shinichiro、Sakiyama Michiyo、Kinjo Takao
- Journal Title
  
  Menopause
  
  Volume: 30 Issue: 2 Pages: 193-200
- DOI
  10.1097/gme.0000000000002125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10084, KAKENHI-PROJECT-20K08655
[Journal Article] Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage2021
- Author(s)
  Uehara K, Tanabe Y, Hirota S, Higa S, Toyoda Z, Kurima K, Kina S, Nakasone T, Arasaki A, Kinjo T.
- Journal Title
  
  BMC Cancer.
  
  Volume: 21 Issue: 1 Pages: 688-688
- DOI
  10.1186/s12885-021-08397-0
- NAID
  120007168809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08655, KAKENHI-PROJECT-21K10084
[Journal Article] A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates2021
- Author(s)
  Kina S, Kawabata-Iwakawa R, Miyamoto S, Arasaki A, Sunakawa H, Kinjo T.
- Journal Title
  
  J Drug Target.
  
  Volume: 29 Issue: 10 Pages: 1118-1127
- DOI
  10.1080/1061186x.2021.1929256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08655, KAKENHI-PROJECT-21K10084
[Journal Article] Fyn‐mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin‐releasing hormone receptor2020
- Author(s)
  Higa‐Nakamine Sayomi、Okitsu‐Sakurayama Shiho、Kina Shinichiro、Yamamoto Hideyuki
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 16 Pages: 1-12
- DOI
  10.1111/febs.15231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07112, KAKENHI-PROJECT-17K11881
[Journal Article] K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation2019
- Author(s)
  Tamanaha-Nakasone Ayumi、Uehara Karina、Tanabe Yasuka、Ishikawa Haruna、Yamakawa Natsuko、Toyoda Zensei、Kurima Kiyoto、Kina Shinichiro、Tsuneki Masayuki、Okubo Yuko、Yamaguchi Sayaka、Utsumi Daisuke、Takahashi Kenzo、Arakawa Hirofumi、Arasaki Akira、Kinjo Takao
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-019-42763-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17030, KAKENHI-PROJECT-16K10167, KAKENHI-PROJECT-16K10436, KAKENHI-PROJECT-18K08303, KAKENHI-PROJECT-18K09773, KAKENHI-PROJECT-19K08778, KAKENHI-PROJECT-17K11881, KAKENHI-PROJECT-19K21277, KAKENHI-PROJECT-20K20305
[Journal Article] Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma2018
- Author(s)
  Kina Shinichiro、Nakasone Toshiyuki、Kinjo Takao、Nimura Fumikazu、Sunagawa Nao、Arasaki Akira
- Journal Title
  
  Clinical Oral Investigations
  
  Volume: - Issue: 6 Pages: 1-6
- DOI
  10.1007/s00784-018-2689-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11881, KAKENHI-PROJECT-18K09729
[Journal Article] Targeting EphA4 abrogates intrinsic resistance to chemotherapy in well-differentiated cervical cancer cell line.2018
- Author(s)
  Kina S, Kinjo T, Liang F, Nakasone T, Yamamoto H, Arasaki A.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 840 Pages: 70-78
- DOI
  10.1016/j.ejphar.2018.09.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11881, KAKENHI-PROJECT-18K09729
[Journal Article] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.2017
- Author(s)
  Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
- Journal Title
  
  Diabetologia.
  
  Volume: 60 Issue: 6 Pages: 1138-1152
- DOI
  10.1007/s00125-017-4259-6
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04816, KAKENHI-PROJECT-15H06519, KAKENHI-PROJECT-15K15046, KAKENHI-PROJECT-15K21251, KAKENHI-PROJECT-15K08238, KAKENHI-PROJECT-15K10644, KAKENHI-PROJECT-16K09519, KAKENHI-PROJECT-16H00594, KAKENHI-PROJECT-17K09839
[Presentation] 耳下腺の基底細胞腺腫摘出から長期経過後に上唇に認められた基底細胞腺腫の一例　ーWnt/β-cateninシグナル経路異常の観点からー2023
- Author(s)
  喜名美香，高山　優，金　舞，齋藤恵実,近松一朗,横尾　聡
- Organizer
  第77回NPO法人　日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-23K16141
[Presentation] 高分化型口腔扁平上皮癌が有するメトロノーム化学療法耐性機構の解明2022
- Author(s)
  喜名振一郎、宮本昇、加藤大貴
- Organizer
  第４０回口腔腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K10084
[Presentation] 早期舌扁平上皮癌患者に対してUFT およびS-1 を投与した術前化学療法2019
- Author(s)
  喜名振一郎、仁村文和、金城貴夫、砂川奈穂、喜名美香、新崎章、仲宗根敏幸
- Organizer
  第５７回日本癌治療学会　福岡国際会議場
- Data Source
  KAKENHI-PROJECT-19K19171
[Presentation] 食事中のnitriteおよびnitrateの不足は代謝症候群、内皮機能不全、および心血管死を惹起する2017
- Author(s)
  喜名美香　坂梨まゆ子　谷本昭英　松﨑俊博　野口克彦　仲宗根淳子　下川宏明　喜名振一郎　砂川　元　大屋祐輔　新崎　章　筒井正人
- Organizer
  第46回日本心脈管作動物質学会
- Place of Presentation
  琉球大学　（沖縄県中頭郡西原町）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-15H06519
[Presentation] 低 NO2- / NO3- 食の長期的な摂取はメタボリックシンドロームを惹起する2017
- Author(s)
  坂梨まゆ子, 喜名美香, 野口克彦, 松崎俊博, 仲宗根淳子, 平良雄司, 久保田陽秋, 戸塚裕一,　筒井正人
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター　（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H06519
[Presentation] 受容体型チロシンキナーゼEphA4 の高分化型腫瘍における抗癌剤耐性能について2017
- Author(s)
  喜名振一郎、山本秀幸、仲嶺三代美、鳥原英嗣、金城貴夫、新崎章
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K11881
[Presentation] Long-Term Dietary Nitrite and Nitrate Deficiency Causes Metabolic Syndrome in Mice.2016
- Author(s)
  Tsutsui M, Kina-Tanada M, Sakanashi M, Ishida M, Uchida T, Kubota H, Matsuzaki T, Noguchi K, Nakasone J, Shimokawa H, Ohya Y, Arasaki A.
- Organizer
  American Heart Association, Scientific Sessions 2016.
- Place of Presentation
  Ernest N. Morial Convention Center, New Orleans, Lousiana, USA.
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06519
[Presentation] Long-term dietary nitrite and nitrate deficiency causes metabolic syndrome in mice.2016
- Author(s)
  Tsutsui M, Kina-Tanada M, Sakanashi M, Ishida M, Ohya Y, Shimokawa H, Arasaki A.
- Organizer
  The 9th Interbnational Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.
- Place of Presentation
  Sendai International Center, Sendai, Japan
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06519
[Presentation] Pathogenetic Role of the Exogenous NO Production System in Metabolic Syndrome.2016
- Author(s)
  Tsutsui M, Kina-Tanada M, Sakanashi M, Otsuji Y, Shimokawa H, Arasaki A.
- Organizer
  The 9th Interbnational Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Sendai International Center, Sendai, Japan
- Year and Date
  2016-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06519

1. Kina Shinichiro (40422422)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 金城貴夫 (30284962)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. Nakasone Toshiyuki (40381214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 宮本昇 (80749565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 川端麗香 (90721928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SAKANASHI Mayuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. KANAME Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUZAKI Toshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. NOGUCHI Katsuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. NAKASONE Junko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. TAIRA Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. ARASAKI Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. TSUTSUI Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. SATOH Kimio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 上原佳里奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 比嘉三代美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山本秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kina Mika 喜名 美香

Research Projects

Research Products

Co-Researchers

口腔癌と内臓脂肪型肥満の間に生じる組織学的分化度依存的なネットワークの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism for metronomic chemotherapy resistance in well-differentiated oral cancer driven by EphA4 activation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of chemotherapy resistance relating the obese signaling pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of molecular biological mechanism targeting EphA4 against the anticancer drug resistance well-differentiated oral squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of new therapy method that targets EphA4 which is activated by chemotherapeutic reagents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanism of the metabolic syndrome induced by long-term dietary nitrite and nitrate deficiency and development of the new treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Higher overall survival rates of oral squamous cell carcinoma treated with metronomic neoadjuvant chemotherapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fyn‐mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin‐releasing hormone receptor2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation2019

Author(s)

Journal Title

DOI

Kina Mika 喜名美香

[Presentation] 耳下腺の基底細胞腺腫摘出から長期経過後に上唇に認められた基底細胞腺腫の一例　ーWnt/β-cateninシグナル経路異常の観点からー2023