Tsuboi Hiroto 坪井洋人

… Alternative Names

TSUBOI Hiroto 坪井洋人

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Researcher Number	80580505
Affiliation (Current)	2025: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 筑波大学, 医学医療系, 准教授 2011 – 2021: 筑波大学, 医学医療系, 講師
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology / Pathobiological dentistry/Dental radiology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Surgical dentistry / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator IgG4関連疾患 / シェーグレン症候群 / CCL18 / 口唇唾液腺 / CCR8 / ケモカイン / single cell RNA-Seq / パスウェイ解析 / 主成分分析 / B細胞 … More / T細胞 / 末梢血単核球 / 顎下腺 / RNA-Seq / モデルマウス / CCL8 / 涙腺 / DNAマイクロアレイ / 自己免疫疾患 / インターフェロンγ / 自己反応性T細胞 / 自己抗体 / M3ムスカリン作働性アセチルコリン受容体 … More Except Principal Investigator IgG4関連疾患 / モデルマウス / マクロファージ / Toll様受容体 / 自然免疫 / B細胞 / T細胞サブセット / 疾患モデルマウス / TLR8 / シェーグレン症候群 / Toll 様受容体 / Toll様受容体8 / 病因 / IgG4疾患モデルマウス / IgG4産生B細胞 / TLR7 / T細胞 / 多様性 / 抗自律神経節アセチルコリン受容体抗体 / 自律神経外障害 / 小児神経 / サルコイドーシス / 膠原病 / 能動免疫 / 自律神経節アセチルコリン受容体 / 自律神経障害 / 動物モデル / 自己抗体 / 自律神経節 / 自己免疫性自律神経節障害 / マクロファージサブセット / CCL16 / M2マクロファージ / B細胞サブセット / 濾胞性T細胞 / TNF-α / Toll 様受容体 8 / ヒトTLR8 Tg/マウスTLR8 KO マウス / 単球/マクロファージ / ミクリッツ病 / M2 マクロファージ / IL-33 Less

IgG4陽性形質細胞の多寡に着目したsingle cell RNA-SeqによるIgG4関連疾患の病態解明Principal Investigator
- Principal Investigator
  
  坪井洋人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Tsukuba
Toll様受容体8に着目したシェーグレン症候群の新たな診断・治療戦略
- Principal Investigator
  
  森山雅文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Gene expression analysis by RNA-Seq and development of novel therapeutic target in IgG4-related diseasePrincipal Investigator
- Principal Investigator
  
  Tsuboi Hiroto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Tsukuba
Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Multidisciplinary analysis of heterogeneity in autoimmune autonomic ganglionopathy
- Principal Investigator
  
  Nakane Shunya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nippon Medical School
  Kumamoto University
Analysis of CCL18-CCR8 signal for developing new therapeutic strategy in IgG4-related diseasePrincipal Investigator
- Principal Investigator
  
  Tsuboi Hiroto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Tsukuba
Novel therapeutic strategies for Sjogren's syndrome targeting Toll-like receptors.
- Principal Investigator
  
  Moriyama Masafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Elucidation of mechanism on IgG4-related disease and establishment of disease model mouse
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
CCL18-CCR8 axis and novel disease specific therapeutic targets for IgG4-related diseasePrincipal Investigator
- Principal Investigator
  
  Tsuboi Hiroto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  University of Tsukuba
New strategy targeted at innate immunity for the pathologic clarification of new disease concept "IgG4-related disease"
- Principal Investigator
  
  Moriyama Masafumi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Immuno-genetic approaches for investigation of pathogenesis of new disease entity "IgG4-related disease"Principal Investigator
- Principal Investigator
  
  TSUBOI Hiroto
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  University of Tsukuba
Autoimmune response to M3 muscarinic acetylcholine receptor in Sjogren's syndromePrincipal Investigator
- Principal Investigator
  
  TSUBOI Hiroto
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  University of Tsukuba

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] ケモカインとIgG4関連疾患、IgG4研究会モノグラフ2015
- Author(s)
  坪井洋人、中井雄治、飯塚麻菜、森山雅文、吉原俊雄、中村誠司、阿部啓子、住田孝之
- Total Pages
  6
- Publisher
  前田書店
- Data Source
  KAKENHI-PROJECT-25870087
[Book] IgG4関連疾患　実践的臨床から病因へ　IgG4研究会モノグラフ　ケモカインとIgG4関連疾患2015
- Author(s)
  坪井洋人、中井雄治、飯塚麻菜、森山雅文、吉原俊雄、中村誠司、阿部啓子、住田孝之
- Total Pages
  206
- Publisher
  前田書店
- Data Source
  KAKENHI-PROJECT-15K09519
[Journal Article] RORγt antagonist improves Sj?gren's syndrome‐like sialadenitis through downregulation of CD252020
- Author(s)
  Ono Yuko、Tsuboi Hiroto、Moriyama Masafumi、Asashima Hiromitsu、Kudo Hanae、Takahashi Hiroyuki、Honda Fumika、Abe Saori、Kondo Yuya、Takahashi Satoru、Matsumoto Isao、Nakamura Seiji、Sumida Takayuki
- Journal Title
  
  Oral Diseases
  
  Volume: - Issue: 4 Pages: 766-777
- DOI
  10.1111/odi.13255
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-17K09966, KAKENHI-PROJECT-18K16137, KAKENHI-PROJECT-17H04671
[Journal Article] Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases.2020
- Author(s)
  Imamura M, Mukaino A, Takamatsu K, Tsuboi H, Higuchi O, Nakamura H, Abe S, Ando Y, Matsuo H, Nakamura T, Sumida T, Kawakami A, Nakane S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 4 Pages: 1332-1332
- DOI
  10.3390/ijms21041332
- NAID
  120007132699
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17012, KAKENHI-PROJECT-19H03549
[Journal Article] IgG4-related pleural disease with aortitis and submandibular glands involvement successfully treated with corticosteroid: case-based review2020
- Author(s)
  Okamoto S, Tsuboi H, Sato R, Terasaki M, Terasaki T, Toko H, Shimizu M, Honda F, Yagishita M, Ohyama A, Kurata I, Abe S, Takahashi H, Osada A, Hagiwara S, Kondo Y, Matsumoto I, Sumida T
- Journal Title
  
  Rheumatol Int
  
  Volume: Epub Issue: 10 Pages: 1725-1732
- DOI
  10.1007/s00296-020-04555-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08381
[Journal Article] Pathogenesis of IgG4-related disease. Comparison with Sjogren's syndrome2020
- Author(s)
  Tsuboi H, Honda F, Takahashi H, Ono Y, Abe S, Kondo Y, Matsumoto I, Sumida T
- Journal Title
  
  Mod Rheumatol
  
  Volume: 30 Issue: 1 Pages: 7-16
- DOI
  10.1080/14397595.2019.1650694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08381
[Journal Article] Upregulation and pathogenic roles of CCL18-CCR8 axis in IgG4-related disease2019
- Author(s)
  Tsuboi Hiroto、Iizuka-Koga Mana、Asashima Hiromitsu、Takahashi Hiroyuki、Kudo Hanae、Ono Yuko、Honda Fumika、Iizuka Akira、Segawa Seiji、Abe Saori、Yagishita Mizuki、Yokosawa Masahiro、Kondo Yuya、Moriyama Masafumi、Matsumoto Isao、Nakamura Seiji、Sumida Takayuki
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 4 Pages: 1-9
- DOI
  10.1080/14397595.2019.1632061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-18K08381
[Journal Article] Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease.2017
- Author(s)
  Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T, Iizuka-Koga M, Tsuboi H, Hayashida JN, Ishiguro N, Yamauchi M, Sumida T, Nakamura S
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 42413-42413
- DOI
  10.1038/srep42413
- NAID
  120007135019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-17K18092, KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-16J07704, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-17H04671
[Journal Article] Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjogren’s syndrome with other sets of criteria in Japanese patients.2017
- Author(s)
  Tsuboi H., Hagiwara S., Asashima H., Takahashi H., Harota T., Noma H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ozawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., Sumida T.
- Journal Title
  
  Ann. Rheum. Dis.
  
  Volume: 3 Issue: 12 Pages: 2016-210758
- DOI
  10.1136/annrheumdis-2016-210758
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05020, KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-26670869, KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-16K11463, KAKENHI-PROJECT-26293430
[Journal Article] cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjogren's syndrome2017
- Author(s)
  Takahashi H, Tsuboi H, Asashima H, Hirota T, Kondo Y, Moriyama M, Matsumoto, Nakamura S, Sumida T.
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: 190 Issue: 1 Pages: 96-109
- DOI
  10.1111/cei.13000
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-16K20934, KAKENHI-PROJECT-17H01603
[Journal Article] A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease2017
- Author(s)
  Masaki Y, Matsui S, Saeki T, Tsuboi H, et al
- Journal Title
  
  Modern Rheumatology
  
  Volume: 27 Pages: 849-854
- Data Source
  KAKENHI-PROJECT-15K09519
[Journal Article] IgG4関連疾患の病因-分子生物学的アプローチ2017
- Author(s)
  坪井洋人、飯塚麻菜、高橋広行、浅島弘充、廣田智哉、近藤裕也、中井雄治、阿部啓子、田中昭彦、森山雅文、中村誠司、吉原俊雄、松本功、住田孝之
- Journal Title
  
  日本臨床リウマチ学会雑誌
  
  Volume: 29 Pages: 128-139
- NAID
  130006068221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09519
[Journal Article] Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease2017
- Author(s)
  Furukawa S, Moriyama N, Miyake K, Nakashima H, Tanaka A, Maehara T, Iizuka-Koga M, Tsuboi H, Hayashida JN, Ishiguro N, Yamauchi M, Sumida T, Nakamura S
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 42413-42413
- NAID
  120007135019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09519
[Journal Article] DNA microarray analysis of submandibular glands in IgG4-related disease indicates a role for MARCO and other innate immune related proteins2016
- Author(s)
  Ohta M, Moriyama M, Maehara T, Gion Y, Furukawa S, Tanaka A, Hayashida JN, Yamauchi M, Ishiguro N, Mikami Y, Tsuboi H, Iizuka-Koga M, Kawano S, Sato Y, Kiyoshima T, Sumida T, Nakamura S.
- Journal Title
  
  Medicine
  
  Volume: 97 Issue: 7 Pages: e2853-e2853
- DOI
  10.1097/md.0000000000002853
- NAID
  120007135530
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-26670869, KAKENHI-PROJECT-15K11075
[Journal Article] Clinical features of patients with IgG4-related disease complicated with perivascular lesions2015
- Author(s)
  Ebe H, Tsuboi H, Hagiya C, Takahashi H, Yokosawa M, Hagiwara S, Hirota T, Kurashima Y, Takai C, Miki H, Asashima H, Umeda N, Kondo Y, Ogishima H, Suzuki T, Chino Y, Matsumoto I, Sumida T
- Journal Title
  
  Modern Rheumatology
  
  Volume: 25 Pages: 105-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870087
[Journal Article] Clinicopathological features of IgG4-related disease complicated with orbital involvement2014
- Author(s)
  Hagiya C, Tsuboi H, Yokosawa M, Hagiwara S, Takai C, Hirota T, Asashima H, Miki H, Umeda N, Horikoshi M, Kondo Y, Sugihara M, Ogishima H, Suzuki T, Hiraoka T, Kaji Y, Matsumoto I, Ohshika T, Sumida T
- Journal Title
  
  Modern Rheumatology
  
  Volume: 24 Pages: 471-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870087
[Journal Article] Clinical features of patients with IgG4-related disease complicated with perivascular lesions2014
- Author(s)
  Ebe H, Tsuboi H, Hagiya C, Takahashi H, Yokosawa M, Hagiwara S, Hirota T, Kurashima Y, Takai C, Miki H, Asashima H, Umeda N, Kondo Y, Ogishima H, Suzuki T, Chino Y, Matsumoto I, Sumida T
- Journal Title
  
  Mod Rheumatol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870087
[Journal Article] DNA microarray analysis of labial salivary glands in IgG4-related disease. Comparison with Sjögren’s syndrome.2014
- Author(s)
  Tsuboi H, Nakai Y, Iizuka1 M, Asashima H, Hagiya C, Tsuzuki S, Hirota T, Miki H, Hagiwara S, Kondo Y, Tanaka A, Moriyama M, Matsumoto I, Nakamura S, Yoshihara T, Abe K, Sumida T.
- Journal Title
  
  Arthritis and Rheumatology
  
  Volume: 66 Issue: 10 Pages: 2892-2899
- DOI
  10.1002/art.38748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-26670869
[Journal Article] Clinicopathological features of IgG4-related disease complicated with orbital involvement2014
- Author(s)
  Hagiya C, Tsuboi H, Yokosawa M, Hagiwara S, Takai C, Hirota T, Asashima H, Miki H, Umeda N, Horikoshi M, Kondo Y, Sugihara M, Ogishima H, Suzuki T, Hiraoka T, Kaji Y, Matsumoto I, Ohshika T, Sumida T
- Journal Title
  
  Mod Rheumatol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870087
[Journal Article] DNA microarray analysis of labial salivary glands in IgG4-related disease. Comparison with Sjogren's syndrome2014
- Author(s)
  Tsuboi H, Nakai Y, Iizuka M, Asashima H, Hagiya C, Tsuzuki S, Hirota T, Miki H, Hagiwara S, Kondo Y, Tanaka A, Moriyama M, Matsumoto I, Nakamura S, Yoshihara T, Abe K, Sumida T
- Journal Title
  
  Arthritis and Rheumatology
  
  Volume: 66 Pages: 2892-2899
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870087
[Journal Article] Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease.2014
- Author(s)
  Furukawa S, Moriyama M, Tanaka A, Maehara T, Tsuboi H, Iizuka M, Hayashida JN, Ohta M, Saeki T, Notohara K, Nakamura S.
- Journal Title
  
  Clinical Immnology
  
  Volume: 156 Issue: 1 Pages: 9-18
- DOI
  10.1016/j.clim.2014.10.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-26670869, KAKENHI-PROJECT-26861733
[Journal Article] Validation of different sets of criteria for the diagnosis of Sjogren's syndrome in Japanese patients2013
- Author(s)
  Tsuboi H, Hagiwara S, Asashima H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, Takeuchi T, Tanaka Y, Hirata S, Mimori T, Matsumoto I, Sumida T
- Journal Title
  
  Mod Rheumatol
  
  Volume: 23 Pages: 219-225
- NAID
  10031167692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] The crucial roles of IFN-g in the development of M3 muscarinic acetylcholine receptor induced Sjogren's syndrome-like sialadenitis2013
- Author(s)
  Iizuka M, Tsuboi H, Matsuo N, Kondo Y, Asashima H, Matsui M, Matsumoto I, Sumida T
- Journal Title
  
  Mod. Rheumatol
  
  Volume: 23 Pages: 614-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] Analysis of IgG4 class switch-related molecules in IgG4-related disease2012
- Author(s)
  Tsuboi H, Matsuo N, Iizuka M, Tsuzuki S, Kondo Y, Tanaka A, Moriyama M, Matsumoto I, Nakamura S, Sumida T
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 14
- NAID
  120007137060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] Pathogenic role of anti-M3 muscarinic acetylcholine receptor immune response in Sjogren's syndrome2012
- Author(s)
  Sumida T, Iizuka M, Asashima H, Tsuboi H, Matsumoto I
- Journal Title
  
  Presse Med
  
  Volume: 41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] シェーグレン症候群における抗M3ムスカリン作働性アセチルコリン受容体抗体2012
- Author(s)
  坪井　洋人
- Journal Title
  
  医学のあゆみ
  
  Volume: 242 Pages: 573-578
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] Generation and functional analysis of monoclonal antibodies against the second extracellular loop of human M3 muscarinic acetylcholine receptor2012
- Author(s)
  Tsuboi H, Nakamura Y, Iizuka M, Matsuo N, Matsumoto I, Sumida T
- Journal Title
  
  Mod. Rheumatol
  
  Volume: 22 Pages: 264-271
- NAID
  10030615200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjogren's syndrome2012
- Author(s)
  Sumida T, Tsuboi H, Iizuka M, AsashimaH, Matsumoto I
- Journal Title
  
  Mod. Rheumatol
- NAID
  40019381268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791100
[Journal Article] シェーグレン症候群の病態と抗M3ムスカリン作働性アセチルコリン受容体抗体2011
- Author(s)
  坪井　洋人、飯塚　麻菜、住田　孝之
- Journal Title
  
  Medical Practice
  
  Volume: 28 Pages: 1247-1250
- Data Source
  KAKENHI-PROJECT-23791100
[Presentation] RNA-Seqを用いたIgG4関連唾液腺炎病変局所と末梢血間のT/B細胞特異的遺伝子発現比較とパスウェイ解析2023
- Author(s)
  坪井洋人、浅島弘充、本田文香、東光裕史、安部沙織、北田彩子、三木春香、近藤裕也、住田孝之、松本功
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08471
[Presentation] RNA-Seqを用いたIgG4関連唾液腺炎病変局所のT/B細胞特異的発現変動遺伝子の同定とパスウェイ解析2022
- Author(s)
  坪井洋人、浅島弘充、東光裕史、本田文香、安部沙織、高橋広行、近藤裕也、松本功、住田孝之
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08471
[Presentation] New era of molecular targeted therapy for IgG4-related disease2022
- Author(s)
  Hiroto Tsuboi, Fumika Honda, Hirofumi Toko, Ayako Kitada, Yuya Kondo, Takayuki Sumida, and Isao Matsumoto
- Organizer
  Federation of Clinical Immunology Societies (FOCIS) 2022 Annual Meeting Member Society Symposium hosted by Japanese Society of Clinical Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08471
[Presentation] IgG4関連疾患におけるステロイド治療後の再燃例の検討2021
- Author(s)
  田渕大貴、坪井洋人、杉田稔貴、西山泰平、寺崎真由、岡本翔太、寺崎俊彦、清水優、本田文香、栁下瑞希、藏田泉、大山綾子、安部沙織、長田侑、髙橋広行、萩原晋也、近藤裕也、住田孝之、松本功
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08471
[Presentation] RNA-Seqを用いたIgG4関連疾患病変局所のT/B細胞特異的発現変動遺伝子の同定2021
- Author(s)
  坪井洋人、本田文香、安部沙織、高橋広行、近藤裕也、松本功、住田孝之
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08471
[Presentation] IgG4関連疾患モデルマウス（LATマウス）におけるCCL8/CCL1-CCR8経路の解析2020
- Author(s)
  本田文香、坪井洋人、小野由湖、安部沙織、高橋広行、伊藤清亮、山田和徳、川野充弘、近藤裕也、松本功、住田孝之
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08381
[Presentation] IgG4関連疾患におけるCCL18-CCR8経路の意義2019
- Author(s)
  坪井洋人、本田文香、小野由湖、安部沙織、高橋広行、近藤裕也、松本功、住田孝之
- Organizer
  第28回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08381
[Presentation] IgG4関連疾患におけるCCL18-CCR8経路の意義2019
- Author(s)
  坪井洋人、本田文香、工藤華枝、小野由湖、安部沙織、高橋広行、近藤裕也、松本功、住田孝之
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08381
[Presentation] IgG4関連疾患の病変局所におけるCCL18-CCR8シグナルの発現解析2018
- Author(s)
  坪井洋人、浅島弘充、高橋広行、工藤華枝、小野由湖、安部沙織、近藤裕也、松本功、住田孝之
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08381
[Presentation] IgG4関連疾患の新規治療標的開発に向けたCCL18-CCR8経路の発現と機能解析2018
- Author(s)
  坪井洋人、瀬川誠司、飯塚晃、浅島弘充、高橋広行、工藤華枝、小野由湖、本田文香、安部沙織、近藤裕也、松本功、住田孝之
- Organizer
  第27回日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08381
[Presentation] IgG4関連疾患の病因・病態の解明：シェーグレン症候群との比較から見えてきたもの2017
- Author(s)
  坪井洋人、飯塚麻菜、高橋広行、浅島弘充、工藤華枝、小野由湖、安部沙織、近藤裕也、中井雄治、阿部啓子、田中昭彦、森山雅文、中村誠司、松本功、住田孝之
- Organizer
  2017年第4回日本リウマチ学会、ベーシックリサーチカンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-15K09519
[Presentation] IgG4関連疾患の病因-分子生物学的アプローチ-2016
- Author(s)
  坪井洋人、飯塚麻菜、高橋広行、浅島弘充、廣田智哉、近藤裕也、中井雄治、阿部啓子、田中昭彦、森山雅文、中村誠司、吉原俊雄、松本功、住田孝之
- Organizer
  第31回日本臨床リウマチ学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-15K09519
[Presentation] IgG4関連疾患の病変局所におけるCCL18-CCR8シグナルの発現亢進2016
- Author(s)
  坪井洋人、飯塚麻菜、浅島弘充、高橋広行、廣田智哉、近藤裕也、松本功、住田孝之
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15K09519
[Presentation] IgG4関連疾患 vs シェーグレン症候群：遺伝子発現比較からみた病因・病態の違い2016
- Author(s)
  坪井洋人、高橋広行、飯塚麻菜、浅島弘充、廣田智哉、近藤裕也、中井雄治、阿部啓子、田中昭彦、森山雅文、中村誠司、吉原俊雄、松本功、住田孝之
- Organizer
  第25回日本シェーグレン症候群学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-15K09519
[Presentation] Up-regulation of CCL18-CCR8 signaling in patients with IgG4-related disease2015
- Author(s)
  Tsuboi H, Iizuka M, Asashima H, Takahashi H, Hirota T, Kondo Y, Matsumoto I, Sumida T
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09519
[Presentation] Up-regulation of CCL18-CCR8 signaling in affected tissues of patients with IgG4-related disease2015
- Author(s)
  Tsuboi H, Iizuka M, Asashima H, Takahashi H, Hirota T, Kondo Y, Matsumoto I, Sumida T
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K09519
[Presentation] IgG4関連疾患とシェーグレン症候群の口唇唾液腺におけるDNAマイクロアレイによる遺伝子発現2014
- Author(s)
  坪井洋人、中井雄治、飯塚麻菜、浅島弘充、萩谷千裕、都築清歌、廣田智哉、近藤裕也、田中昭彦、森山雅文、松本功、中村誠司、吉原俊雄、阿部啓子、住田孝之
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25870087
[Presentation] 抗M3ムスカリン作働性アセチルコリン受容体抗体とシェーグレン症候群2012
- Author(s)
  坪井　洋人
- Organizer
  第40回　日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23791100
[Presentation] 日本人シェーグレン症候群患者の診断における3つの診断基準の比較2012
- Author(s)
  坪井洋人
- Organizer
  第21回日本シェーグレン症候群学会
- Place of Presentation
  シンポジウム2(京都)
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-23791100
[Presentation] 抗M3ムスカリン作働性アセチルコリン受容体(M3R)抗体とシェーグレン症候群(SS)2012
- Author(s)
  坪井洋人
- Organizer
  第40回日本臨床免疫学会総会
- Place of Presentation
  スポンサードシンポジウム自己抗体(東京)
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-23791100
[Presentation] シェーグレン症候群（SS）における抗M3ムスカリン作働性アセチルコリン受容体（M3R）抗体の機能解析2011
- Author(s)
  坪井　洋人、中村　友美、松尾　直美、飯塚　麻菜、松本　功、住田　孝之
- Organizer
  第39回日本臨床免疫学会総会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791100
[Presentation] Up-regulation of CCL18-CCR8 signaling in patients with IgG4-related disease
- Author(s)
  Hiroto Tsuboi, Mana Iizuka, Hiromitsu Asashima, Hiroyuki Takahashi, Tomoya Hirota, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-25870087
[Presentation] DNAマイクロアレイによるIgG4関連疾患の口唇唾液腺における遺伝子発現解析
- Author(s)
  坪井洋人、中井雄治、飯塚麻菜、浅島弘充、高橋広行、廣田智哉、近藤裕也、古川祥子、田中昭彦、森山雅文、松本功、吉原俊雄、中村誠司、阿部啓子、住田孝之
- Organizer
  第23回日本シェーグレン症候群学会
- Place of Presentation
  長崎
- Year and Date
  2014-09-12 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25870087

1. Moriyama Masafumi (20452774)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. Nakamura Seiji (60189040)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
3. 柴田琢磨 (30554505)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 新納宏昭 (20380636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 安河内友世 (70507813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKAI Yuji (10321788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Nakane Shunya (70398022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中島衡 (70188960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 三宅健介 (60229812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 池田徳典 (00613530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐藤伸一 (20215792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 田村直人 (20227284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 樋口理 (50361720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 鈴木隆二 (70373470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 伊原栄吉 (80612390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 宋文杰 (90216573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 川上純 (90325639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐藤和貴郎 (90469990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 前原隆 (10637333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MATSUMOTO Naoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 井上裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 斎藤一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 向野晃弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuboi Hiroto 坪井 洋人

TSUBOI Hiroto 坪井 洋人

Research Projects

Research Products

Co-Researchers

IgG4陽性形質細胞の多寡に着目したsingle cell RNA-SeqによるIgG4関連疾患の病態解明Principal Investigator

Principal Investigator

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Toll様受容体8に着目したシェーグレン症候群の新たな診断・治療戦略

Principal Investigator

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Gene expression analysis by RNA-Seq and development of novel therapeutic target in IgG4-related diseasePrincipal Investigator

Principal Investigator

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Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease

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Multidisciplinary analysis of heterogeneity in autoimmune autonomic ganglionopathy

Principal Investigator

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Analysis of CCL18-CCR8 signal for developing new therapeutic strategy in IgG4-related diseasePrincipal Investigator

Principal Investigator

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Novel therapeutic strategies for Sjogren's syndrome targeting Toll-like receptors.

Principal Investigator

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Elucidation of mechanism on IgG4-related disease and establishment of disease model mouse

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CCL18-CCR8 axis and novel disease specific therapeutic targets for IgG4-related diseasePrincipal Investigator

Principal Investigator

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New strategy targeted at innate immunity for the pathologic clarification of new disease concept "IgG4-related disease"

Principal Investigator

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Immuno-genetic approaches for investigation of pathogenesis of new disease entity "IgG4-related disease"Principal Investigator

Principal Investigator

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Autoimmune response to M3 muscarinic acetylcholine receptor in Sjogren's syndromePrincipal Investigator

Principal Investigator

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Research Institution

[Book] ケモカインとIgG4関連疾患、IgG4研究会モノグラフ2015

Author(s)

Total Pages

Tsuboi Hiroto 坪井洋人

TSUBOI Hiroto 坪井洋人

[Book] IgG4関連疾患　実践的臨床から病因へ　IgG4研究会モノグラフ　ケモカインとIgG4関連疾患2015