NAKAHARA Fumio 中原史雄

… Alternative Names

Nakahara Fumio 中原史雄

中原史雄ナカハラフミオ

Less

Researcher Number	80581181
Other IDs	https://orcid.org/0000-0003-1515-8284
Affiliation (Current)	2025: 自治医科大学, 医学部, 准教授 2025: 東京大学, 医科学研究所, 特任研究員
Affiliation (based on the past Project Information) *help	2023: 自治医科大学, 医学部, 准教授 2020: 東京大学, 医学部附属病院, 講師 2010 – 2013: The University of Tokyo, 医科学研究所, 助教 2010: 東京大学, 医科学研究, 助教
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Hematology
Keywords	Principal Investigator 急性転化 / 慢性骨髄性白血病 / 白血病幹細胞 / 白血病 / 再賦活化骨髄間葉系幹細胞 / 微小環境 / 造血幹細胞 / 間葉系幹細胞 Except Principal Investigator マウス骨髄移植モデル / EZH2 … More / ASXL1 / miRNA / エピジェネティクス / 骨随意形成症候群 / 白血病 / 遺伝子 / 内科 / 発現制御 / シグナル伝達 / 癌 / 血液腫瘍学 Less

Development of artificial bone marrow graft using revitalized bone marrow mesenchymal stem cells.Principal Investigator
- Principal Investigator
  
  Nakahara Fumio
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
  The University of Tokyo
Integrative elucidation of molecular mechanisms for leukemogenesis: Identification and analyses of mutations with novel categories.
- Principal Investigator
  
  KITAMURA Toshio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Molecular mechanisms of blast crisis transition and maintenance of leukemic stem cells in chronic myelogenous leukemiaPrincipal Investigator
- Principal Investigator
  
  NAKAHARA Fumio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Molecular mechanisms of blast crisis transition and maintenance of leukemic stem cells in chronic myelogenous leukemiaPrincipal Investigator
- Principal Investigator
  
  NAKAHARA Fumio
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

All 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis.2014
- Author(s)
  Uchida T, Kawabata KC, Kitamura T., et al.
- Journal Title
  
  Exp Hematol.
  
  Volume: S0301-472X(14) Issue: 5 Pages: 56-3
- DOI
  10.1016/j.exphem.2014.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J09414, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-25461422
[Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.2014
- Author(s)
  Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
- Journal Title
  
  Blood
  
  Volume: 123(25) Issue: 25 Pages: 3932-42
- DOI
  10.1182/blood-2013-01-476747
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09414, KAKENHI-PLANNED-22112007, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24591382, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-25461422, KAKENHI-PROJECT-25860521, KAKENHI-PROJECT-26293231, KAKENHI-PROJECT-26461415
[Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells2014
- Author(s)
  Nakahara, F
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249051
[Journal Article] Human CD300C Delivers an Fc Receptor-gamma-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition2013
- Author(s)
  Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T and Kitaura J
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 7662-75
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations.2013
- Author(s)
  Inoue, D
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 123 Issue: 11 Pages: 4627-4640
- DOI
  10.1172/jci70739
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-23310183, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-25461422
[Journal Article] Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models2012
- Author(s)
  Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H and Kitamura T
- Journal Title
  
  Int JHematol
  
  Volume: 95 Pages: 167-75
- NAID
  10030267340
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.2012
- Author(s)
  Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H and Kitamura T
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 1038-45
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning2012
- Author(s)
  Shibata-Minoshima F, Oki T, Doki N,Nakahara F, Kageyama S, Kitaura J, Fukuoka J and Kitamura T
- Journal Title
  
  Int J Oncol
  
  Volume: 40 Pages: 93-8
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide2012
- Author(s)
  Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F,Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T and Kitaura J
- Journal Title
  
  Immunity
  
  Volume: 37 Pages: 827-39
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Transforming growth factor-beta-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis2012
- Author(s)
  Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, Kume H, Homma Y and Kitamura T
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 26-33
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice2012
- Author(s)
  Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H and Kitamura T
- Journal Title
  
  Int J Hematol
  
  Volume: 96 Pages: 638-48
- NAID
  10031126762
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML)2012
- Author(s)
  Kitamura T, Watanabe-Okochi N, InoueD, Togami K, Uchida T, Kagiyama Y, Kawabata K, Chiba S, Harada Y, Harada H, Kitaura J and Nakahara F
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 53 Pages: 734-9
- NAID
  130004501712
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis2012
- Author(s)
  Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T
- Journal Title
  
  Leukemia
  
  Volume: (in press) Issue: 5 Pages: 1038-1045
- DOI
  10.1038/leu.2011.328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591206, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-22591038, KAKENHI-PUBLICLY-23118518, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-23390257, KAKENHI-PROJECT-23791074, KAKENHI-PROJECT-24591398
[Journal Article] A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis2012
- Author(s)
  Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T and Kitaura J
- Journal Title
  
  J Immuno
  
  Volume: l189 Pages: 1773-9
- Data Source
  KAKENHI-PROJECT-23791074
[Journal Article] 慢性骨髄性白血病の急性転化におけるHeslの関与2011
- Author(s)
  中原史雄
- Journal Title
  
  臨床血液
  
  Volume: in press掲載確定
- Data Source
  KAKENHI-PROJECT-22890043
[Journal Article] Two types of C/EBPa mutations play distinct roles in leukemogenesis : Lessons from clinical data and BMT models2011
- Author(s)
  Kato, N
- Journal Title
  
  Blood
  
  Volume: 117 Issue: 1 Pages: 221-233
- DOI
  10.1182/blood-2010-02-270181
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-22591038, KAKENHI-PROJECT-23249051
[Journal Article] Two types of C/EBPalpha mutations play distinct but collaborative roles in leukemogenesis : lessons from clinical data and BMT models.2011
- Author(s)
  Kato N., J.Kitaura, N.Doki, Y.Komeno, N.Watanabe-Okochi, K.Togami, F.Nakahara, T.Oki, Y.Enomoto, Y.Fukuchi, H.Nakajima, Y.Harada, H.Harada, T.Kitamura
- Journal Title
  
  Blood 117
  
  Pages: 221-233
- Data Source
  KAKENHI-PROJECT-22890043
[Journal Article] One-year low-dose valacyclovir as prophylaxis for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation. A prospective study of the Japan Hematology and Oncology Clinical Study Group.2010
- Author(s)
  Oshima K., T.Takahashi, T.Mori, T.Matsuyama, K.Usuki, Y.Asano-Mori, F.Nakahara, S.Okamoto, M.Kurokawa, Y.Kanda
- Journal Title
  
  Transpl Infect Dis 12
  
  Pages: 421-427
- Data Source
  KAKENHI-PROJECT-22890043
[Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.2010
- Author(s)
  Nakahara F., M.Sakata-Yanagimoto, Y.Komeno, N.Kato, T.Uchida, K.Haraguchi, K.Kumano, Y.Harada, H.Harada, J.Kitaura, S.Ogawa, M.Kurokawa, T.Kitamura, S.Chiba
- Journal Title
  
  Blood 115
  
  Pages: 2872-2881
- NAID
  10029425017
- Data Source
  KAKENHI-PROJECT-22890043
[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010
- Author(s)
  Komeno Y., J.Kitaura, N.Watanabe-Okochi, N.Kato, T.Oki, F.Nakahara, Y.Harada, H.Harada, R.Shinkura, H.Nagaoka, Y.Hayashi, T.Honjo, T.Kitamura
- Journal Title
  
  Leukemia 24
  
  Pages: 1018-1024
- Data Source
  KAKENHI-PROJECT-22890043
[Journal Article] Hesl immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.2010
- Author(s)
  Nakahara F
- Journal Title
  
  Blood
  
  Volume: 115(14) Pages: 2872-2881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890043
[Presentation] Molecular mechanisms of blast crisis in chronic myelogenous leukemia caused by upregulation of Hes12012
- Author(s)
  Fumio Nakahara, Toshio Kitamura
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23791074
[Presentation] Leukemogenesis induced by C-terminal mutations in the basic leucine zipper domain of C/EBPα2012
- Author(s)
  戸上勝仁, 北浦次郎, 井上大地, 鍵山侑希, 内田智之, 西村耕太郎, 土岐典子, 加藤菜穂子, 中原史雄, 沖俊彦, 原田結花, 原田浩徳, 北村俊雄
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都国際会館
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23249051
[Presentation] Molecular Mechanisms of blast crisis in chronic myelogenous leukemia caused by upregulation of Hes12012
- Author(s)
  中原史雄, 北浦次郎, 川畑公人, 内田智之,鍵山侑希, 井上大地, 戸上勝仁, 沖俊彦, 原田結花 , 原田浩徳 , 北村俊雄
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都国際会館
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23249051
[Presentation] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myeloid leukemia.2011
- Author(s)
  Fumio Nakahara, Toshio Kitamura, 他
- Organizer
  日米血液腫瘍セミナー2011
- Place of Presentation
  神奈川県葉山湘南国際村センター
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-22890043
[Presentation] Hesl immortalizes committed progenitors and plays a role in blast crisis transition in chronic myeloid leukemia.2011
- Author(s)
  中原史雄
- Organizer
  日米血液腫瘍セミナー2011
- Place of Presentation
  葉山湘南国際村センター
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-22890043
[Presentation] Hairy enhance of split1 (Hes1)による造血前駆細胞の不死化と慢性骨髄性白血病の急性転化誘導2011
- Author(s)
  中原史雄
- Organizer
  「個体レベルでのがん研究支援活動」ワークショップ
- Place of Presentation
  滋賀県琵琶湖ホテル
- Year and Date
  2011-02-03
- Data Source
  KAKENHI-PROJECT-22890043
[Presentation] Molecular mechanisms of blast crisis in chronic myelogenous leukemia2011
- Author(s)
  中原史雄
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23249051
[Presentation] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myeloid leukemia.2011
- Author(s)
  Fumio Nakahara, Toshio Kitamura, 他
- Organizer
  「個体レベルでのがん研究支援活動」ワークショップ
- Place of Presentation
  滋賀県琵琶湖ホテル
- Year and Date
  2011-02-03
- Data Source
  KAKENHI-PROJECT-22890043
[Presentation] Molecular Mechanisms of blast crisis in chronic myelogenous leukemia caused by upregulation of Hes1.
- Author(s)
  中原史雄
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-23249051

1. KITAMURA Toshio (20282527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. KITAURA Jiro (30282651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAHARA Fumio 中原 史雄

Nakahara Fumio 中原 史雄

中原 史雄 ナカハラ フミオ

Research Projects

Research Products

Co-Researchers

Development of artificial bone marrow graft using revitalized bone marrow mesenchymal stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrative elucidation of molecular mechanisms for leukemogenesis: Identification and analyses of mutations with novel categories.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of blast crisis transition and maintenance of leukemic stem cells in chronic myelogenous leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of blast crisis transition and maintenance of leukemic stem cells in chronic myelogenous leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells2014

Author(s)

Journal Title

Data Source

[Journal Article] Human CD300C Delivers an Fc Receptor-gamma-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition2013

Author(s)

Journal Title

Data Source

[Journal Article] Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.2012

Author(s)

Journal Title

Data Source

[Journal Article] Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning2012

Author(s)

Journal Title

Data Source

[Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide2012

Author(s)

Journal Title

Data Source

[Journal Article] Transforming growth factor-beta-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis2012

Author(s)

Journal Title

Data Source

[Journal Article] Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML)2012

NAKAHARA Fumio 中原史雄

Nakahara Fumio 中原史雄

中原史雄ナカハラフミオ