Yoshimoto Yuya 吉本由哉

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YOSHIMOTO Yuya 吉本由哉

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Researcher Number	80594390
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 公私立大学の部局等, 教授
Affiliation (based on the past Project Information) *help	2024: 福島県立医科大学, 公私立大学の部局等, 准教授 2021 – 2023: 福島県立医科大学, 医学部, 准教授 2022: 福島県立医科大学, 公私立大学の部局等, 准教授 2019 – 2020: 福島県立医科大学, 医学部, 講師 2017 – 2018: 群馬大学, 重粒子線医学推進機構, 助教 2017: 群馬大学, 医学部附属病院, 助教 2011 – 2012: 群馬大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 52040:Radiological sciences-related / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 抗腫瘍免疫 / 放射線治療抵抗性 / 子宮頸癌 / 放射線治療 / 個別化医療 / 分子標的 / 免疫回避 / 腫瘍免疫学 / 放射線腫瘍学 / 腫瘍免疫 … More / 腫瘍浸潤T細胞 / 変異解析 / precision medicine / 分子標的薬 / リキッドバイオプシー / 網羅的遺伝子解析 / 癌精巣抗原 … More Except Principal Investigator 放射線治療 / PD-L1 / 免疫チェックポイント阻害剤 / 乳癌 / 免疫放射線治療 / 腫瘍免疫 / 抗腫瘍免疫 / 体細胞変異 / 子宮頸癌 / anti-PD-L1抗体薬 / コロニー形成法 / 抗PD-L1抗体 / 免疫逃避機構 / 放射線増感効果 / 抗PD-L1抗体薬 / 免疫放射線療法 / 腫瘍関連マクロファージ / 脳神経疾患 / 病理学 / 疾患モデル動物 / グリオーマ / 脳腫瘍 Less

Enhancing Anti-Tumor Immunity in Radiation Therapy through Molecular Targeted DrugsPrincipal Investigator
- Principal Investigator
  
  吉本由哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
放射線治療と免疫チェックポイント阻害剤併用療法患者における腫瘍免疫学的解析
- Principal Investigator
  
  鈴木義行
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
Prediction of radiotherapy/immunotherapy treatment outcome of cervical cancer by liquid biopsyPrincipal Investigator
- Principal Investigator
  
  Yoshimoto Yuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
The translational research of somatic mutations related to immune responsiveness in radiation therapy
- Principal Investigator
  
  Murata Kazutoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Basic study of immunoradiation therapy using anti-PD-L1 antibody
- Principal Investigator
  
  Hara Takamitsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Gunma Prefectural College of Health Sciences
Translational Research and Immunoradiotherapy in Advanced CancerPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO YUYA
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
  Gunma University
Analysis of transgenic rats prone to brain tumors.
- Principal Investigator
  
  YOKOO HIDEAKI
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Gunma University
Study for radiotherapy-induced tumor specific immunity.Principal Investigator
- Principal Investigator
  
  YOSHIMOTO Yuya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Gunma University

All 2024 2023 2020 2019 2018 2017 2012 Other

All Journal Article Presentation

[Journal Article] Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer2024
- Author(s)
  １．Mimura K, Ogata T, Nguyen P, Roy S, Kared H, Yuan YC, Fehlings M, Yoshimoto Y, Yoshida D, Nakajima S, Sato H, Machida N, Yamada T, Watanabe Y, Tamaki T, Fujikawa H, Inokuchi Y, Hayase S, Hanayama H, Saze Z, Katoh H, Takahashi F, Oshima T, Goel A, Nardin A, Suzuki Y, Kono K.
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 12 Issue: 1 Pages: e008385-e008385
- DOI
  10.1136/jitc-2023-008385
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07799, KAKENHI-PROJECT-23K08114, KAKENHI-PROJECT-23K24410
[Journal Article] Immunological Responses Associated With Neoadjuvant Therapy in the Tumor Microenvironment of Esophageal Squamous Cell Carcinoma2023
- Author(s)
  Yuka Takehara, Tomoaki Tamaki, Kosaku Mimura, Katsuharu Saito, Prajwal Neupane, Takeshi Tada, Yohei Watanabe, Suguru Hayase, Zenichiro Saze, Yuya Yoshimoto, Hisashi Sato, Koji Kono, Yoshiyuki Suzuki
- Journal Title
  
  Anticancer Res .
  
  Volume: 43 Issue: 10 Pages: 4691-4700
- DOI
  10.21873/anticanres.16665
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07799, KAKENHI-PROJECT-20K09083
[Journal Article] Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer2023
- Author(s)
  ３．Mimura K, Ogata T, Yoshimoto Y, Yoshida D, Nakajima S, Sato H, Machida N, Yamada T, Watanabe Y, Tamaki T, Fujikawa H, Inokuchi Y, Hayase S, Hanayama H, Saze Z, Katoh H, Takahashi F, Oshima T, Suzuki Y, Kono K.
- Journal Title
  
  Commun Med (Lond) .
  
  Volume: 15 Issue: 1 Pages: 111-111
- DOI
  10.1038/s43856-023-00343-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07799, KAKENHI-PROJECT-20K09083, KAKENHI-PROJECT-23K24410
[Journal Article] Treatment outcomes of patients with adenocarcinoma of the uterine cervix after definitive radiotherapy and the prognostic impact of tumor-infiltrating CD8+ lymphocytes in pre-treatment biopsy specimens: a multi-institutional retrospective study2020
- Author(s)
  Miyasaka Yuhei、Yoshimoto Yuya、Murata Kazutoshi、Noda Shin-ei、Ando Ken、Ebara Takeshi、Okonogi Noriyuki、Kaminuma Takuya、Yamada Seiji、Ikota Hayato、Yokoo Hideaki、Ohno Tatsuya、Nakano Takashi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 61 Issue: 2 Pages: 275-284
- DOI
  10.1093/jrr/rrz106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10469, KAKENHI-PROJECT-18K07767
[Journal Article] Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.2018
- Author(s)
  Nuryadi E, Sasaki Y, Hagiwara Y, Permata TBM, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda SE, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, Nakano T
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 32642-32652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10469
[Journal Article] A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades.2017
- Author(s)
  Nakata S, Horiguchi K, Ishiuchi I, Yoshimoto Y, Yamada S, Nobusawa S, Ikota H, Hirato J, Yokoo H.
- Journal Title
  
  Neuropathology
  
  Volume: 37 Issue: 4 Pages: 351-357
- DOI
  10.1111/neup.12370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290017
[Journal Article] Histone H3 K27M mutations in adult cerebellar high-grade gliomas.2017
- Author(s)
  Nakata S, Nobusawa S, Yamazaki T, Osawa T, Horiguchi K, Hashiba Y, Yaoita H, Matsumura N, Ikota H, Hirato J, Yoshimoto Y, Yokoo H.
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: 34 Issue: 3 Pages: 113-119
- DOI
  10.1007/s10014-017-0288-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290017
[Journal Article] Immunogenic tumor cell death induced by chemoradiotherapy in patients with esophageal squamous cell carcinoma2012
- Author(s)
  Suzuki Y, Mimura K, Yoshimoto Y, Watanabe M, Ohkubo Y, Izawa S, Murata K, Fujii H, Nakano T, Kono K
- Journal Title
  
  Cancer Res
  
  Volume: 72(16) Pages: 3967-3976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791393
[Presentation] がん関連遺伝子ターゲットシークエンスによる子宮頸癌放射線治療感受性因子の探索2019
- Author(s)
  吉本由哉、尾池貴洋、佐々木泰史、村田和俊、宮坂勇平、野田真永、大野達也、時野隆至、鈴木義行、中野隆史
- Organizer
  日本放射線腫瘍学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-17K10469
[Presentation] Mutational Profiling of Japanese Cervical Cancer Patients Treated with Radiotherapy2019
- Author(s)
  Yuya Yoshimoto, Takahiro Oike, Yasushi Sasaki, Endang Nuryadi, Kazutoshi Murata, Takuya Kaminuma, Daisuke Irie, Daijiro Kobayashi, Tatsuya Ohno, Takashi Tokino, Takashi Nakano
- Organizer
  The 9th Annual Meeting of The International Society of Radiation Neurobiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10469
[Presentation] 放射線による抗腫瘍免疫誘導に関する検討2012
- Author(s)
  吉本由哉、鈴木義行、三村耕作、河野浩二、中野隆史
- Organizer
  第21回日本癌病態治療研究会
- Place of Presentation
  前橋テルサ(前橋)
- Year and Date
  2012-07-07
- Data Source
  KAKENHI-PROJECT-23791393
[Presentation] 放射線による抗腫瘍免疫の活性化2012
- Author(s)
  吉本由哉、鈴木義行、三村耕筰、河野浩二、中野隆史
- Organizer
  第50回日本放射線腫瘍学会生物部会学術大会
- Place of Presentation
  カルチャーリゾートフェストーネ(沖縄)
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-23791393
[Presentation] Requirement of Anti-tumor Immunity and Enhancement by CTL-associated Antigen-4 Blockade on Therapeutic Efficacy of Radiation Therapy in a Mouse Tumor Model2012
- Author(s)
  Yuya Yoshimoto
- Organizer
  54th ASTRO
- Place of Presentation
  Boston, US
- Data Source
  KAKENHI-PROJECT-23791393
[Presentation] 放射線と免疫細胞療法の併用療法2012
- Author(s)
  吉本由哉
- Organizer
  第9会日本免疫治療学研究会学術集会(招待講演)
- Place of Presentation
  東京ガーデンパレス（東京都）
- Data Source
  KAKENHI-PROJECT-23791393
[Presentation] Requirement of Anti- tumor Immunity and Enhancement byCTL-associated Antigen-4 Blockade on Therapeutic Efficacy of Radiation Therapy in a Mouse Tumor Model2012
- Author(s)
  Yoshimoto Y, Suzuki Y, Mimura K, Kono K and Nakano T
- Organizer
  54th Annual meeting for American Society for Radiation Oncology
- Place of Presentation
  Boston Convention Center, Boston
- Data Source
  KAKENHI-PROJECT-23791393
[Presentation] Therapeutic Impact Of Intravenous-injection Of Microglia On Radiotherapy For Malignant Glioma Arising In S100beta-v-erbB Transgenic Rat.
- Author(s)
  N. Okonogi, Y. Suzuki, H. Yokoo, H. Ohgaki, H. Sato, T. Oike, Y. Yoshimoto, S. Noda, M. Okamoto, T. Nakano.
- Organizer
  American Society for Radiation Oncology (ASTRO), 56th annual meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2014-09-14 – 2014-09-17
- Data Source
  KAKENHI-PROJECT-25290017

1. 鈴木義行 (60334116)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. 尾池貴洋 (10643471)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. Murata Kazutoshi (60644557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 三村耕作 (90568031)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 佐藤浩央 (90750571)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. YOKOO HIDEAKI (40282389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. SUGAWARA Kenichi (50375573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Hara Takamitsu (70464542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐々木惇 (80225862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊古田勇人 (90420116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 信澤純人 (80635318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 村上孝 (00326852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 田巻倫明 (20400749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中神佳宏 (80347301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 川村拓 (80424050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 野田真永 (60396645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 竹本靖 (50453543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OHGAKI Hiroko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Yoshimoto Yuya 吉本 由哉

YOSHIMOTO Yuya 吉本 由哉

Research Projects

Research Products

Co-Researchers

Enhancing Anti-Tumor Immunity in Radiation Therapy through Molecular Targeted DrugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

放射線治療と免疫チェックポイント阻害剤併用療法患者における腫瘍免疫学的解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of radiotherapy/immunotherapy treatment outcome of cervical cancer by liquid biopsyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The translational research of somatic mutations related to immune responsiveness in radiation therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic study of immunoradiation therapy using anti-PD-L1 antibody

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Translational Research and Immunoradiotherapy in Advanced CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of transgenic rats prone to brain tumors.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for radiotherapy-induced tumor specific immunity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunological Responses Associated With Neoadjuvant Therapy in the Tumor Microenvironment of Esophageal Squamous Cell Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment outcomes of patients with adenocarcinoma of the uterine cervix after definitive radiotherapy and the prognostic impact of tumor-infiltrating CD8+ lymphocytes in pre-treatment biopsy specimens: a multi-institutional retrospective study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.2018

Author(s)

Journal Title

Data Source

[Journal Article] A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades.2017

Author(s)

Journal Title

Yoshimoto Yuya 吉本由哉

YOSHIMOTO Yuya 吉本由哉