Yamano Shotaro 山野荘太郎

… Alternative Names

YAMANO Shotaro 山野荘太郎

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Researcher Number	80614528
Other IDs	https://orcid.org/0000-0002-3611-622X
Affiliation (Current)	2025: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 有害性試験研究領域病理グループ, 上席試験研究員
Affiliation (based on the past Project Information) *help	2024: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 有害性試験研究領域病理グループ, 上席試験研究員 2022 – 2023: 独立行政法人労働者健康安全機構日本バイオアッセイ研究センター(試験管理部、病理検査部), その他部局等, 室長補佐 2019 – 2021: 独立行政法人労働者健康安全機構日本バイオアッセイ研究センター(試験管理部、病理検査部), その他部局等, 主任研究員 2017: 独立行政法人労働者健康安全機構日本バイオアッセイ研究センター(試験管理部、病理検査部), その他部局等, 研究員 2016: 国立研究開発法人国立がん研究センター, 研究所, 特任研究員 2015: 大阪市立大学, 大学院医学研究科, 助教 2013 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 53030:Respiratory medicine-related / Dermatology / Urology / Respiratory surgery Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator 肺疾患 / scRNAseq / シングルセル解析 / じん肺 / pneumoconiosis / single-cell RNAseq / マイクロミニピッグ / ブタ / 1細胞解析 / 職業性肺疾患 … More / 職業性呼吸器疾患 / シングルセルアトラス / 病理 / 肺がん / 肺線維症 / 肺線維化 / 肺胞蛋白症 / 呼吸器疾患 / TAS-Seq / 酸化インジウムスズ / 結晶質シリカ / 塵肺 / 職業性疾患 / RCS / シリカ / SITO / インジウム / 皮膚メラノーマ / 悪性黒色腫 / 皮膚腫瘍 / NLS / melanoma / HSF1 / IER5 / クラスター / 高転移株 / 腎細胞癌 / 癌細胞塊 / 肺転移 / TET/on / lung / TET/On / deltaNp63 … More Except Principal Investigator スクリーニング / 発がんメカニズム / 職業性膀胱がん / oncomodulin / 短期予測モデル / 膀胱発がん性 / 芳香族アミン / 動物モデル / 呼吸細気管支 / インジウム / 職業性肺疾患 / ブタ / 職業性呼吸器疾患 / シングルセル解析 / アスベスト肺 / MWCNT Less

Elucidating the pathology of MWCNT lung disease using pigs and a scRNA-seq
- Principal Investigator
  
  梅田ゆみ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  National Institute of Occupational Safety and Health,Japan
Redefining dust-induced lung disease with reference to ILA
- Principal Investigator
  
  菅沼成文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kochi University
Generation of pneumoconiosis atlas unraveling at 1-cell resolutionPrincipal Investigator
- Principal Investigator
  
  山野荘太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  National Institute of Occupational Safety and Health,Japan
  Japan Organization of Occupational Health and Safety Japan Bioassay Research Center
職業性膀胱がんの予防に資する短期尿路上皮発がんスクリーニングシステムの開発
- Principal Investigator
  
  魏民
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Osaka Metropolitan University
Comprehensive Fundamental Research on the Onset and Development of Pneumoconiosis Using TAS-SeqPrincipal Investigator
- Principal Investigator
  
  Yamano Shotaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Japan Organization of Occupational Health and Safety Japan Bioassay Research Center
Role of IER5-HSF1 axis in malignant melanoma carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Yamano Shotaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Japan Organization of Occupational Health and Safety Japan Bioassay Research Center
Elucidation of tumor microenvironment formation mechanism in metastatic lesion using new metastatic renal carcinoma model and its application to therapyPrincipal Investigator
- Principal Investigator
  
  Yamano Shotaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  National Cancer Center Japan
  Osaka City University
Establishment of novel lung SCC model using deltaNp63 inducible systemPrincipal Investigator
- Principal Investigator
  
  YAMANO Shotaro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Osaka City University

All 2023 2022 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model2023
- Author(s)
  Goto Yuko、Saito Arata、Takanobu Kenji、Senoh Hideki、Saito Misae、Umeda Yumi、Yamano Shotaro
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-28825-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08556
[Journal Article] Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers2023
- Author(s)
  Yamano Shotaro、Takeda Tomoki、Goto Yuko、Hirai Shigeyuki、Furukawa Yusuke、Kikuchi Yoshinori、Misumi Kyohei、Suzuki Masaaki、Takanobu Kenji、Senoh Hideki、Saito Misae、Kondo Hitomi、Kobashi Yoichiro、Okamoto Kenzo、Kishimoto Takumi、Umeda Yumi
- Journal Title
  
  Respiratory Research
  
  Volume: 24 Issue: 1
- DOI
  10.1186/s12931-023-02355-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08556
[Journal Article] Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats2022
- Author(s)
  Takeda T, Yamano S, Goto Y, Hirai S, Furukawa Y, Kikuchi Y, Misumi K, Suzuki M, Takanobu K, Senoh H, Saito M, Kondo H, Daghlian G, Hong YK, Yoshimatsu Y, et al.
- Journal Title
  
  Particle Fibre and Toxicology
  
  Volume: 19 Issue: 1
- DOI
  10.1186/s12989-022-00468-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07094, KAKENHI-PROJECT-20K08556
[Journal Article] No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model2022
- Author(s)
  Yamano Shotaro、Takeda Tomoki、Goto Yuko、Hirai Shigeyuki、Furukawa Yusuke、Kikuchi Yoshinori、Kasai Tatsuya、Misumi Kyohei、Suzuki Masaaki、Takanobu Kenji、Senoh Hideki、Saito Misae、Kondo Hitomi、Umeda Yumi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-19139-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08556
[Journal Article] Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study2022
- Author(s)
  Yamano Shotaro、Goto Yuko、Takeda Tomoki、Hirai Shigeyuki、Furukawa Yusuke、Kikuchi Yoshinori、Kasai Tatsuya、Misumi Kyohei、Suzuki Masaaki、Takanobu Kenji、Senoh Hideki、Saito Misae、Kondo Hitomi、Umeda Yumi
- Journal Title
  
  Particle and Fibre Toxicology
  
  Volume: 19 Issue: 1
- DOI
  10.1186/s12989-022-00498-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08556
[Journal Article] Non-degradable autophagic vacuoles are indispensable for cell competition2022
- Author(s)
  Akter Eilma、Tasaki Yukihiro、Mori Yusuke、Nakai Kazuki、Hachiya Kazuki、Lin Hancheng、Konno Masamitsu、Kamasaki Tomoko、Tanabe Kenji、Umeda Yumi、Yamano Shotaro、Fujita Yasuyuki、Kon Shunsuke
- Journal Title
  
  Cell Reports
  
  Volume: 40 Issue: 9 Pages: 111292-111292
- DOI
  10.1016/j.celrep.2022.111292
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05285, KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-20K07559, KAKENHI-PROJECT-20K08556
[Journal Article] A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks.2017
- Author(s)
  Yamaguchi T, Gi M, Yamano S, Fujioka M, Tatsumi K, Kawachi S, Ishii N, Doi K, Kakehashi A, Wanibuchi H.
- Journal Title
  
  Exp Toxicol Pathol
  
  Volume: 69 Issue: 1 Pages: 1-7
- DOI
  10.1016/j.etp.2016.10.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H06550, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-15K20105, KAKENHI-PROJECT-16K20158
[Journal Article] Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers.2017
- Author(s)
  Tachibana H, Gi M, Kato M, Yamano S, Fujioka M, Kakehashi A, Hirayama Y, Koyama Y, Tamada S, Nakatani T, Wanibuchi H.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 3 Pages: 331-337
- DOI
  10.1111/cas.13143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-15K20105, KAKENHI-PROJECT-16K20158
[Journal Article] Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay2017
- Author(s)
  Ishii N, Gi M, Fujioka M, Yamano S, Okumura M, Kakehashi A, Wanibuchi H.
- Journal Title
  
  Journal of Toxicologic Pathology
  
  Volume: 30 Issue: 1 Pages: 39-45
- DOI
  10.1293/tox.2016-0049
- NAID
  130005297205
- ISSN
  0914-9198, 1881-915X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-15K20105, KAKENHI-PROJECT-16K20158
[Journal Article] Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.2016
- Author(s)
  Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
- Journal Title
  
  J Cell Biol.
  
  Volume: 212 Issue: 4 Pages: 409-423
- DOI
  10.1083/jcb.201507046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15KT0086, KAKENHI-PROJECT-15K08324, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-26440111, KAKENHI-ORGANIZER-24113001, KAKENHI-PLANNED-24113005, KAKENHI-PLANNED-24113007, KAKENHI-PROJECT-25460089, KAKENHI-PROJECT-26650071, KAKENHI-PROJECT-15K20105, KAKENHI-PROJECT-15H02398
[Journal Article] Anti-PD-L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma.2016
- Author(s)
  Hirayama Y, Gi M, Yamano S, Tachibana H, Okuno T, Tamada S, Nakatani T, Wanibuchi H.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 12 Pages: 1736-1744
- DOI
  10.1111/cas.13099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-15K20105, KAKENHI-PROJECT-16K20157
[Journal Article] The role of deltaNp63pos CD44vpos cells in the development of NTCU-induced peripheral type of mouse lung squamous cell carcinomas..2016
- Author(s)
  Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama S, Tachibana H, Ishii N, Fujioka M, Tatsumi K,Wanibuchi H.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 2 Pages: 123-132
- DOI
  10.1111/cas.12855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-25462499, KAKENHI-PROJECT-15H06550, KAKENHI-PROJECT-15K20105
[Journal Article] Determination of Hepatotoxicity and its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.2015
- Author(s)
  Gi M, Fujioka M, Yamano S, Shimomura E, Ishii N, Kakehashi A, Takeshita M, Wanibuchi H.
- Journal Title
  
  Toxicol Sci.
  
  Volume: 145 Pages: 196-208
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861248
[Journal Article] Clinicopathological significance of combined analysis of cytokeratin19 expression and preoperative serum CYFRA21-1 levels in human lung squamous cell carcinoma.2013
- Author(s)
  Hanada S, Nishiyama N, Mizuguchi S, Yamano S, Kakehashi A, Wei M, Inoue H, Komatsu H, Chung K, Suehiro S, Wanibuchi H.
- Journal Title
  
  Osaka City Med J
  
  Volume: 59 Pages: 35-44
- NAID
  120006493288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861248
[Journal Article] Evaluation of the Modifying Effect of Inhalation of Mainstream Cigarette Smoke on Mouse Bladder Carcinogenesis2013
- Author(s)
  kato M, Wei M, Yamano S, et al.
- Journal Title
  
  Journal of Toxicologic Pathology
  
  Volume: 26 Issue: 4 Pages: 447-451
- DOI
  10.1293/tox.2013-0039
- NAID
  130003382468
- ISSN
  0914-9198, 1881-915X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592406, KAKENHI-PROJECT-25861248, KAKENHI-PROJECT-25893206
[Journal Article] Insulin-ameliorated peripheral motor neuropathy in spontaneously diabetic WBN/Kob rats.2013
- Author(s)
  Ozaki K, Yamano S, Matsuura T, Narama I.
- Journal Title
  
  J Vet Med Sci
  
  Volume: 75 Pages: 1323-1328
- NAID
  130003362226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861248
[Journal Article] Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.2013
- Author(s)
  Wei M, Yamada T, Yamano S, Kato M, Kakehashi A, Fujioka M, Tago Y, Kitano M, Wanibuchi H.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 253 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861248
[Journal Article] L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes.2013
- Author(s)
  Xie XL, Kakehashi A, Wei M, Yamano S, Takeshita M, Yunoki T, Wanibuchi H.
- Journal Title
  
  Food Chem Toxicol.
  
  Volume: 59 Pages: 137-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861248
[Journal Article] Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors.2013
- Author(s)
  Komatsu H, Kakehashi A, Nishiyama N, Izumi N, Mizuguchi S, Yamano S, Inoue H, Hanada S, Chung K, Wei M, Suehiro S, Wanibuchi H.
- Journal Title
  
  Cancer Biomark
  
  Volume: 13 Pages: 171-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861248
[Presentation] p53標的遺伝子IER5は新規の低リン酸化型の活性化HSF1を作り出し、がん化を促進する2017
- Author(s)
  山野荘太郎
- Organizer
  第11回臨床ストレス応答学会
- Place of Presentation
  山口大学医学部（山口県宇部市）
- Year and Date
  2017-11-11
- Data Source
  KAKENHI-PROJECT-15K20105
[Presentation] ラット腎癌肺高転移株を用いた転移亢進に寄与するCAMsに関する検討2016
- Author(s)
  山野荘太郎
- Organizer
  第25回日本がん転移学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-07-21
- Data Source
  KAKENHI-PROJECT-15K20105
[Presentation] EHEN誘発ラット腎発がんにおいて内因性NADPH oxidase 阻害剤 apocyninは抑制作用を有する2014
- Author(s)
  三島胡桃、山野荘太郎、魏民、藤岡正喜、鰐渕英機
- Organizer
  第30回日本毒性病理学会総会および学術集会
- Place of Presentation
  あわぎんホール（徳島県）
- Data Source
  KAKENHI-PROJECT-25861248
[Presentation] EHEN投与ラットの前腸由来臓器への分化多能性を示す肝芽腫の一例2014
- Author(s)
  山野荘太郎、尾崎清和、武田周二、串田昌彦、井澤武史、山手丈至、平田暁大、藤岡正喜、魏民、鰐渕英機
- Organizer
  第30回日本毒性病理学会総会および学術集会
- Place of Presentation
  あわぎんホール（徳島県）
- Data Source
  KAKENHI-PROJECT-25861248
[Presentation] 内因性NADPHオキシダーゼインヒビターであるアポサイニンはラット腎発がんにおいて発がん抑制作用を有する2013
- Author(s)
  山野荘太郎、魏民、藤岡正喜、多胡義幸、北野光明、三島胡桃、鰐渕英機
- Organizer
  第７２回に本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-25861248

1. 高須正規 (00503327)

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2. 杉原英志 (50464996)

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3. 七野成之 (70822435)

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4. 新井佐知子 (10409831)

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5. 山本雄介 (60768117)

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6. 風間啓 (80845298)

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7. 大木理恵子 (70356252)

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8. 梅田ゆみ (00792300)

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9. 菅沼成文 (50313747)

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10. 佐野有司 (50162524)

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11. 栄徳勝光 (50552733)

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12. 小廣和哉 (60170370)

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13. 西村泰光 (90360271)

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14. 魏民 (70336783)

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15. 塩田正之 (30381990)

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16. 米村重信

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17. 吉松康裕

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18. 土井賢一郎

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19. 鰐渕英機

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20. 藤田恭之

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Yamano Shotaro 山野 荘太郎

YAMANO Shotaro 山野 荘太郎

Research Projects

Research Products

Co-Researchers

Elucidating the pathology of MWCNT lung disease using pigs and a scRNA-seq

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Redefining dust-induced lung disease with reference to ILA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of pneumoconiosis atlas unraveling at 1-cell resolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

職業性膀胱がんの予防に資する短期尿路上皮発がんスクリーニングシステムの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive Fundamental Research on the Onset and Development of Pneumoconiosis Using TAS-SeqPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of IER5-HSF1 axis in malignant melanoma carcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of tumor microenvironment formation mechanism in metastatic lesion using new metastatic renal carcinoma model and its application to therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel lung SCC model using deltaNp63 inducible systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-degradable autophagic vacuoles are indispensable for cell competition2022

Author(s)

Yamano Shotaro 山野荘太郎

YAMANO Shotaro 山野荘太郎