AKIYAMA Hisako 秋山央子

… Alternative Names

秋山央子アキヤマヒサコ

Akiyama Hisako 秋山央子

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Researcher Number	80623462
Other IDs
Affiliation (Current)	2025: 順天堂大学, 健康総合科学先端研究機構, 特任助教
Affiliation (based on the past Project Information) *help	2023: 順天堂大学, 健康総合科学先端研究機構, 特任助教 2018 – 2020: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 2016 – 2018: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 2017: 国立研究開発法人理化学研究所, その他部局等, 研究員 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 … More 2016: 国立研究開発法人理化学研究所, 脳科学総合研究センター・神経膜機能研究チーム, 研究員 2015: 国立研究開発法人理化学研究所, その他部局等, 研究員 2015: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / General medical chemistry / Neurology
Keywords	Principal Investigator グルコシルセラミド分解酵素 / 糖脂質 / 糖化ステロール / グルコシルセラミド / コレステロール / GBA / パーキンソン病 / 中性グルコシルセラミド分解酵素 / エクソソーム / 神経変性疾患 … More / GBA2 / 糖化 / ステロール / GBA1 / 糖化コレステロール / コレステリルグルコシド … More Except Principal Investigator αシヌクレイン / パーキンソン病 / glucocerebrosidase / 多系統萎縮症 / 神経変性疾患 / アフィテニティクロマトグラフィー / 異性体分離 / 脂質メタボローム解析 / イオンモビリティーシステム / 腎疾患 / 肥満 / 神経新生 / 脂質メタボローム / 気相分離 / 親水性相互作用クロマトグラフィー / 固相抽出 / グルコース化脂質 / 脳神経疾患 / ゴーシェ病 / マウス / メダカ / GBA1 / 脂質 Less

中性グルコシルセラミド分解酵素を介した神経変性疾患発症機構の解明Principal Investigator
- Principal Investigator
  
  秋山央子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Juntendo University
Development of a histochemical analytical system for metabolic enzymes of novel brain glycosylated sterolsPrincipal Investigator
- Principal Investigator
  
  Akiyama Hisako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research
Investigating the pathogenesis and development of therapeutics of alpha-synucleinopathy
- Principal Investigator
  
  Takahashi Ryosuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
Development of an analytical platform for novel brain glycosylated sterols toward applying for the treatment of neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Akiyama Hisako
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research
Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations
- Principal Investigator
  
  Takahashi Ryosuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Development of glycosylated lipid metabolomics system for clarifying their neuronal function
- Principal Investigator
  
  Nakajima Kazuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Fujita Health University
  Institute of Physical and Chemical Research
Parkinson's disease pathogenesis mediated by glycosylation of cholesterolPrincipal Investigator
- Principal Investigator
  
  Akiyama Hisako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] モデル動物利用マニュアル　疾患モデルの作製と利用－脂質代謝異常と関連疾患2015
- Author(s)
  秋山央子, 香山綾子, 平林義雄
- Total Pages
  16
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-26860199
[Book] 生命を支える脂質―最新の研究と臨床2014
- Author(s)
  秋山央子、平林義雄
- Total Pages
  1228
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26860199
[Journal Article] Impact of GBA2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)2021
- Author(s)
  Nakanishi, E., Uemura, N., Akiyama, H., Kinoshita, M., Sawamura, M., Taruno, Y., Yamakado, H., Matsuzawa, S., Takeda, S., Hirabayashi, Y., and Takahashi, R.
- Journal Title
  
  Molecular Brain
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KK0147
[Journal Article] Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol2020
- Author(s)
  Akiyama, H., Ide, M., Nagatsuka, Y., Sayano, T., Nakanishi, E., Uemura, N., Yuyama, K., Yamaguchi, Y., Kamiguchi, H., Takahashi, R., Aerts, J. M. F. G., Greimel, P. and Hirabayashi, Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 16 Pages: 5257-5277
- DOI
  10.1074/jbc.ra119.012502
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0147, KAKENHI-PROJECT-16K14687, KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-18K06456, KAKENHI-PROJECT-18H04041, KAKENHI-PROJECT-16H06290, KAKENHI-PROJECT-19H03362
[Journal Article] Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish2019
- Author(s)
  Lelieveld, L. T., Mirzaian, M, Kuo, C-L., Artola M., Ferraz, M. J., Peter, R. E. A., Akiyama, H., Greimel, P., van den Berg, R. J. B. H. N., Overkleeft, H. S., Boot, R. G., Meijer, A. H., and Aerts, J. M. F. G.
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 60 Issue: 11 Pages: 1851-1867
- DOI
  10.1194/jlr.ra119000154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0147
[Journal Article] GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson’s disease2019
- Author(s)
  Ikuno Masashi、Yamakado Hodaka、Akiyama Hisako、Parajuli Laxmi Kumar、Taguchi Katsutoshi、Hara Junko、Uemura Norihito、Hatanaka Yusuke、Higaki Katsumi、Ohno Kousaku、Tanaka Masaki、Koike Masato、Hirabayashi Yoshio、Takahashi Ryosuke
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Issue: 11 Pages: 1894-1904
- DOI
  10.1093/hmg/ddz030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-17KK0147, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-17H03553, KAKENHI-PROJECT-18H04041, KAKENHI-PROJECT-16K09672
[Journal Article] Pathological Structural Conversion of α-Synuclein Mediated by Glycosphingolipids2018
- Author(s)
  秋山央子
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 30 Issue: 174 Pages: J85-J86
- DOI
  10.4052/tigg.1813.6J
- NAID
  130006744117
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2018-05-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-17KK0147
[Journal Article] Regulatory mechanism of sterylglucoside metabolism by glucocerebrosidase2018
- Author(s)
  秋山央子, 平林義雄
- Journal Title
  
  生化学
  
  Volume: 90 Issue: 3 Pages: 399-402
- DOI
  10.14952/SEIKAGAKU.2018.900399
- NAID
  40021622671
- ISSN
  0037-1017
- Year and Date
  2018-06-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16K14687, KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-17KK0147
[Journal Article] Pathological Structural Conversion of α-Synuclein Mediated by Glycosphingolipids2018
- Author(s)
  秋山央子
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 30 Issue: 174 Pages: E111-E112
- DOI
  10.4052/tigg.1813.6E
- NAID
  130006744118
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2018-05-25
- Language
  English
- Data Source
  KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-17KK0147
[Journal Article] A novel function for glucocerebrosidase as a regulator of sterylglucoside metabolism2017
- Author(s)
  Akiyama H. and Hirabayashi Y
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1861 Issue: 10 Pages: 2507-2514
- DOI
  10.1016/j.bbagen.2017.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14687, KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-16H06290, KAKENHI-PROJECT-15H02540
[Journal Article] 脳における新たなステロール代謝経路：糖化ステロール群の発見2016
- Author(s)
  秋山央子，平林義雄
- Journal Title
  
  JSBMS Letters
  
  Volume: 41 Pages: 43-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02540
[Journal Article] Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular beta-glucosidases2016
- Author(s)
  Marques, A. R. Mirzaian, M. Akiyama, H. Wisse, P. Ferraz, M. J. Gaspar, P. Ghauharali-van der Vlugt, K. Meijer, R. Giraldo, P. Alfonso, P. Irun, P. Dahl, M. Karlsson, S. Pavlova, E. V. Cox, T. M. Scheij, S. Verhoek, M. Ottenhoff, R. van Roomen, C. P. Pannu, N. S. van Eijk, M. Dekker, N. Boot, R. G., et al.
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 57 Issue: 3 Pages: 451-463
- DOI
  10.1194/jlr.m064923
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860199, KAKENHI-PROJECT-16H06290
[Journal Article] Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety.2016
- Author(s)
  Nakajima K, Akiyama H, Tanaka K, Kohyama-Koganeya A, Greimel P, Hirabayashi Y.
- Journal Title
  
  J Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  
  Volume: 1031 Pages: 146-53
- DOI
  10.1016/j.jchromb.2016.07.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-26860199, KAKENHI-PROJECT-16H06290
[Journal Article] Aglycon diversity of brain sterylglucosides: Structure determination of cholesteryl- and sitosterylglucoside.2016
- Author(s)
  Akiyama H, Nakajima K, Itoh Y, Sayano T, Ohashi Y, Yamaguchi Y, Greimel, P, Hirabayashi Y.
- Journal Title
  
  J Lipid Res.
  
  Volume: 57 Issue: 11 Pages: 2061-72
- DOI
  10.1194/jlr.m071480
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-26860199, KAKENHI-PROJECT-16K14687, KAKENHI-PROJECT-16H06290, KAKENHI-PROJECT-16H04758
[Journal Article] . 脳における新たなステロール代謝経路：糖化ステロール群の発見2016
- Author(s)
  秋山央子、平林義雄
- Journal Title
  
  JSBMS Letters
  
  Volume: 41 Pages: 43-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860199
[Journal Article] 糖脂質の新機能－多様な脂質のグルコース修飾機構と意義2014
- Author(s)
  平林義雄、秋山央子、中嶋和紀
- Journal Title
  
  生化学
  
  Volume: 86 Pages: 735-743
- NAID
  40020314088
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] 親水性相互作用クロマトグラフィー-質量分析法を用いた新規脳内糖脂質異性体の発見2021
- Author(s)
  秋山央子
- Organizer
  大阪大学蛋白質研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] Flexible activity of glucocerebrosidase generates a unique glycolipid metabolic network2020
- Author(s)
  秋山央子
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] Glucocerebrosidase mediates a crosstalk between glycosphingolipid and sterol2019
- Author(s)
  Hisako Akiyama
- Organizer
  1st Japan-Europe Workshop on Glycosphingolipids and Membrane Homeostasis, Strasbourg, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04041
[Presentation] グルコシルセラミド分解酵素による新規脳内ステロール代謝物・ステロール配糖体の代謝制御2019
- Author(s)
  秋山央子、井手三津子、中西悦郎、上村紀仁、山口芳樹、Peter Greimel、上口裕之、高橋良輔、平林義雄
- Organizer
  第92回日本生化学会大会、横浜市、神奈川県
- Data Source
  KAKENHI-PROJECT-18H04041
[Presentation] Glucocerebrosidase mediates a crosstalk between glycosphingolipid and sterol2019
- Author(s)
  Hisako Akiyama
- Organizer
  Japan-Europe Workshop on Glycosphingolipids and Membrane Homeostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] グルコシルセラミド分解酵素はステロールとガラクトシルセラミド間のトランスガラクトシレーション反応を触媒する2019
- Author(s)
  秋山央子、井手三津子、Peter Greimel、Hans Aerts、上口裕之、平林義雄
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] Newly identified brain sterol metabolite glycosylated sterols are metabolized by β-glucocerebrosidase 1 and 2 in vivo2019
- Author(s)
  Hisako Akiyama, Mitsuko Ide, Etsuro Nakanishi, Norihito Uemura, Yoshiki Yamaguchi, Hiroyuki Kamiguchi, Ryosuke Takahashi, Peter Greimel and Yoshio Hirabayashi
- Organizer
  25th International Symposium on Glycoconjugates
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] グルコシルセラミド分解酵素による新規脳内ステロール代謝物・ステロール配糖体の代謝制御2019
- Author(s)
  秋山央子、井手三津子、中西悦郎、上村紀仁、山口芳樹、Peter Greimel、上口裕之、高橋良輔、平林義雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] Glucocerebrosidase mediates a crosstalk between glycosphingolipid and sterol2019
- Author(s)
  Hisako Akiyama
- Organizer
  Japan-Europe Workshop on Glycosphingolipids and Membrane Homeostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] Newly identified brain sterol metabolite glycosylated sterols are metabolized by β-glucocerebrosidase 1 and 2 in vivo2019
- Author(s)
  Hisako Akiyama, Mitsuko Ide, Etsuro Nakanishi, Norihito Uemura, Yoshiki Yamaguchi, Hiroyuki Kamiguchi, Ryosuke Takahashi, Peter Greimel and Yoshio Hirabayashi
- Organizer
  25th International Symposium on Glycoconjugates
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] グルコシルセラミド分解酵素はステロールとガラクトシルセラミド間のトランスガラクトシレーション反応を触媒する2019
- Author(s)
  秋山央子、井手三津子、Peter Greimel、Hans Aerts、上口裕之、平林義雄
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] Newly identified brain sterol metabolite glycosylated sterols are metabolized by α-glucocerebrosidase 1 and 2 in vivo2019
- Author(s)
  Hisako Akiyama, Mitsuko Ide, Etsuro Nakanishi, Norihito Uemura, Yoshiki Yamaguchi, Hiroyuki Kamiguchi, Ryosuke Takahashi, Peter Greimel and Yoshio Hirabayashi
- Organizer
  25th International Symposium on Glycoconjugates, Milan, Italy,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04041
[Presentation] グルコシルセラミド分解酵素による新規脳内ステロール代謝物・ステロール配糖体の代謝制御2019
- Author(s)
  秋山央子、井手三津子、中西悦郎、上村紀仁、山口芳樹、Peter Greimel、上口裕之、高橋良輔、平林義雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] Identification of novel brain sterol metabolite galactosylated cholesterol synthesized by glucocerebrosidases2018
- Author(s)
  Hisako Akiyama, Yasuko Nagatsuka, Tomoko Sayano, Mitsuko Ide, Yoshiki Yamaguchi, Peter Greimel, Yoshio Hirabayashi
- Organizer
  Glycolipid & Sphingolipid Biology, Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] グルコシルセラミド分解酵素による脳内ステロール配糖体群の代謝制御2018
- Author(s)
  秋山央子、井手三津子、佐矢野智子、中西悦郎、上村紀仁、Peter Greimel、高橋良輔、平林義雄
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] グルコシルセラミド分解酵素による脳内ステロール配糖体群の代謝制御2018
- Author(s)
  秋山央子、井手三津子、佐矢野智子、中西悦郎、上村紀仁、Peter Greimel、高橋良輔、平林義雄
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17KK0147
[Presentation] Identification of novel brain sterol metabolite galactosylated cholesterol synthesized by glucocerebrosidases2018
- Author(s)
  Hisako Akiyama, Yasuko Nagatsuka, Tomoko Sayano, Mitsuko Ide, Yoshiki Yamaguchi, Peter Greimel, Yoshio Hirabayashi
- Organizer
  Glycolipid & Sphingolipid Biology, Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] ステロールとスフィンゴ脂質の代謝的クロストークが生み出す新たな糖脂質2017
- Author(s)
  秋山央子、中嶋和紀、佐矢野智子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2017
- Author(s)
  中西悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
- Organizer
  第40回神経科学学会
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2017
- Author(s)
  Etsuro Nakanishi, Norihito Uemura, Satoko Akiyama, Masato Kinoshita, Hodaka Yamakado, Shun-ichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
- Organizer
  WCN2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] 脳における多様なステリルグリコシド：コレステロールおよび植物ステロール配糖体の完全構造決定2017
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第65回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] 新規脳内糖化ステロール群の発見：多様なステロールおよび糖鎖構造2017
- Author(s)
  秋山央子、中嶋和紀、佐矢野智子、長塚靖子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第36回日本糖質学会
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] ステロールとスフィンゴ脂質の代謝的クロストークが生み出す新たな糖脂質2017
- Author(s)
  秋山央子、中嶋和紀、佐矢野智子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] 新規脳内糖化ステロール群の発見：多様なステロールおよび糖鎖構造2017
- Author(s)
  秋山央子、中嶋和紀、佐矢野智子、長塚靖子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第36回日本糖質学会
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] Is the GBA2 a new modifier for Gauchers’s disease and GBA1-related Parkinson’s disease?2017
- Author(s)
  Etsuro Nakanishi, Norihito Uemura, Satoko Akiyama, Masato Kinoshita, Hodaka Yamakado, Shun-ichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
- Organizer
  MDS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] 脳における多様なステリルグリコシド：コレステロールおよび植物ステロール配糖体の完全構造決定2017
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第65回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-17K15608
[Presentation] パーキンソン病発症因子・酸性グルコシルセラミド分解酵素GBA1の新規糖脂質代謝産物の発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第35回日本糖質学会年会
- Place of Presentation
  高知市文化プラザかるぽーと (高知県高知市)
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] HILIC-MS/MSを用いたパーキンソン病に関与する新規脳内糖脂質の発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel 、平林義雄
- Organizer
  第41回日本医用マススペクトル学会年会
- Place of Presentation
  名古屋
- Year and Date
  2016-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] HILIC-MS/MSを用いたパーキンソン病に関与する新規脳内糖脂質の発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第41回日本医用マススペクトル学会年会
- Place of Presentation
  ウインクあいち (愛知県名古屋市)
- Year and Date
  2016-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] 新規脂質メタボローム解析技術を用いた微量グルコース化脂質の神経疾患・腎疾患における役割解明2016
- Author(s)
  中嶋和紀、秋山央子、長塚靖子、岩渕和久、高橋和男、湯澤由紀夫、平林義雄
- Organizer
  糖鎖科学中部拠点「第13回若手の力フォーラム」
- Place of Presentation
  岐阜大学応用生物科学部
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2016
- Author(s)
  E Nakanishi, N Uemura, H Akiyama, M Kinoshita, H Yamakado, T Shunichi, Y Hirabayashi, R Takahashi
- Organizer
  第39回神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] HILIC-ESI-MSによるグルコース化異性体の定性・定量分析とその臨床応用2016
- Author(s)
  中嶋和紀、秋山央子、長塚靖子、岩渕和久、高橋和男、湯澤由紀夫、平林義雄
- Organizer
  第35回日本糖質学会年会
- Place of Presentation
  高知市文化プラザかるぽーと
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] Novel glycosylated sterol metabolite in vertebrate brain possible linked to Parkinson's disease2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  Gordon Research Conference, Glycolipid & Sphingolipid Biology
- Place of Presentation
  Lucca, Italy
- Year and Date
  2016-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] パーキンソン病に関与する新規脳内糖化ステロールの発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  にぎわい交流館AU (秋田県秋田市)
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] パーキンソン病発症因子・酸性グルコシルセラミド分解酵素GBA1の新規糖脂質代謝産物の発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel 、平林義雄
- Organizer
  第35回日本糖質学会
- Place of Presentation
  高知
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] HILIC-ESI-MSによるグルコース化異性体の定性・定量分析とその臨床応用2016
- Author(s)
  中嶋和紀、秋山央子、長塚靖子、岩渕和久、高橋和男、湯澤由紀夫、平林義雄
- Organizer
  第41回医用マススペクトル会議年会
- Place of Presentation
  ウィンク愛知
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] パーキンソン病に関与する新規脳内糖化ステロールの発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel 、平林義雄
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] 神経変性疾患発症の新たな分子基盤の解明2016
- Author(s)
  秋山央子
- Organizer
  第15回ホスファチジルセリン研究会
- Place of Presentation
  東京
- Year and Date
  2016-11-18
- Invited
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] 神経型ゴーシェ病モデルメダカの中枢神経におけるGBA2の役割2016
- Author(s)
  中西悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
- Organizer
  第10回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2016
- Author(s)
  E Nakanishi, N Uemura, H Akiyama, M Kinoshita, H Yamakado, T Shunichi, Y Hirabayashi, R Takahashi
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] 新規脳内糖化ステロールの発見 - 神経変性疾患発症の新たな分子基盤の解明 -2016
- Author(s)
  秋山央子
- Organizer
  第15回ホスファチジルセリン研究会
- Place of Presentation
  早稲田大学日本橋キャンパス大ホール(東京都中央区)
- Year and Date
  2016-11-18
- Invited
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2015
- Author(s)
  中西悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-15H02540
[Presentation] Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1
- Author(s)
  秋山央子、中嶋和紀、小林進、室伏きみ子、平林義雄
- Organizer
  第37回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] 酸性グルコシダーゼGBA1の新機能‘コレステロールへのグルコース転移活性’の発見
- Author(s)
  秋山央子、中嶋和紀、小林進、室伏きみ子、平林義雄
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] 両性イオン型(ZIC)-HILIC-ESI-MS/MSによる脳グルコース化脂質の定量解析
- Author(s)
  中嶋和紀、秋山央子、田中香織、平林義雄
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] 双性イオイ性カラム(ZIC)-HILIC-ESI-MSによる脳内グルコース化分子の異性体定量
- Author(s)
  中嶋和紀、秋山央子、田中香織、谷口直之、平林義雄
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋大学
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-26860199
[Presentation] 親水性相互作用クロマトグラフィーを用いたLC/MS/MSによるグルコース化脂質の異性体定量
- Author(s)
  中嶋和紀、秋山央子、田中香織、平林義雄
- Organizer
  セラミド研究会第7回学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS
- Year and Date
  2014-10-30 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-26860199

1. Takahashi Ryosuke (90216771)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. YAMAKADO Hodaka (10378771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. UEMURA Norihito (90749045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. Nakajima Kazuki (10442998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Hirabayashi Yoshio (90106435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Tohda Koji (60212065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Iwabuchi Kazuhisa (10184897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. Kamiguchi Hiroyuki (10233933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 木下政人 (60263125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. Ikuno Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Nakanishi Etsuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. Nagatsuka Yasuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 山門穗高

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
14. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIYAMA Hisako 秋山 央子

秋山 央子 アキヤマ ヒサコ

Akiyama Hisako 秋山 央子

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Co-Researchers

中性グルコシルセラミド分解酵素を介した神経変性疾患発症機構の解明Principal Investigator

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Development of a histochemical analytical system for metabolic enzymes of novel brain glycosylated sterolsPrincipal Investigator

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Investigating the pathogenesis and development of therapeutics of alpha-synucleinopathy

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Development of an analytical platform for novel brain glycosylated sterols toward applying for the treatment of neurodegenerative diseasesPrincipal Investigator

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Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations

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Development of glycosylated lipid metabolomics system for clarifying their neuronal function

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Parkinson's disease pathogenesis mediated by glycosylation of cholesterolPrincipal Investigator

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[Book] モデル動物利用マニュアル 疾患モデルの作製と利用－脂質代謝異常と関連疾患2015

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[Book] 生命を支える脂質―最新の研究と臨床2014

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[Journal Article] Impact of GBA2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)2021

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[Journal Article] Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol2020

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[Journal Article] Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish2019

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[Journal Article] GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson’s disease2019

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[Journal Article] Pathological Structural Conversion of α-Synuclein Mediated by Glycosphingolipids2018

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AKIYAMA Hisako 秋山央子

秋山央子アキヤマヒサコ

Akiyama Hisako 秋山央子

[Book] モデル動物利用マニュアル　疾患モデルの作製と利用－脂質代謝異常と関連疾患2015