• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

MIZUTANI TOMOHIRO  水谷 知裕

… Alternative Names

Mizutani Tomohiro  水谷 知裕

MIZUTANI Tomohiro  水谷 知裕

Less
Researcher Number 80632588
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8373-7969
Affiliation (Current) 2025: 東京科学大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help 2022 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
2020 – 2021: 東京医科歯科大学, 医学部附属病院, 助教
2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / 0903:Organ-based internal medicine and related fields / Gastroenterology
Except Principal Investigator
Medium-sized Section 52:General internal medicine and related fields / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords
Principal Investigator
自己組織化 / 腸管グラフト / iPS細胞 / 腸管スフェロイド / 難治性腸炎 / 炎症性腸疾患 / 短腸症候群 / 人工ペプチド / 下部消化管学(小腸、大腸) / 再生医療 / GMP規格 / 低分子化合物 / 腸管上皮培養 … More
Except Principal Investigator
… More 炎症性腸疾患 / オルガノイド / グラフト / iPS細胞 / 体性幹細胞 / 多能性幹細胞 / 短腸症候群 / 移植 / ディスプラジア / オルガノイド移植 / 炎症性発癌 / Dysplasia / 潰瘍性大腸炎 / 腸上皮オルガノイド / アナジー / 腸管免疫 / 抗原提示細胞 / double negative T細胞 Less
  • Research Projects

    (6 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (12 People)
  •  疾患/臓器/領域レベルでのアナジー誘導性抗原提示細胞;DNT細胞研究の拡大

    • Principal Investigator
      根本 泰宏
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  患者由来大腸オルガノイド移植法を用いたdysplasia-PDOXモデルの開発

    • Principal Investigator
      福田 将義
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  難治性消化管疾患に対する統合オルガノイド医療の創成

    • Principal Investigator
      岡本 隆一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment of refractory inflammatory bowel disease model using human iPS cell-derived self-organizing complex intestinal tissuePrincipal Investigator

    • Principal Investigator
      Mizutani Tomohiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of intestinal graft production and transplantation method using human iPS cell-derived self-organization intestinal organoids.Principal Investigator

    • Principal Investigator
      Mizutani Tomohiro
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0903:Organ-based internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment of a xeno-free primary culture method for human colonic epithelial stem cellsPrincipal Investigator

    • Principal Investigator
      MIZUTANI Tomohiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

All 2023 2022 2021 2014 2013

All Journal Article Presentation

  • [Journal Article] Protocol to generate large human intestinal organoids using a rotating bioreactor2023

    • Author(s)
      Takahashi Junichi、Sugihara Hady Yuki、Kato Shu、Nagata Sayaka、Okamoto Ryuichi、Mizutani Tomohiro
    • Journal Title

      STAR Protocols

      Volume: 4 Issue: 3 Pages: 102374-102374

    • DOI

      10.1016/j.xpro.2023.102374

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19519, KAKENHI-PROJECT-22H00465
  • [Journal Article] Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment2023

    • Author(s)
      Watanabe Satoshi、Ogasawara Nobuhiko、Kobayashi Sakurako、Kirino Sakura、Inoue Masami、Hiraguri Yui、Nagata Sayaka、Shimizu Hiromichi、Ito Go、Mizutani Tomohiro、Nemoto Yasuhiro、Tsuchiya Kiichiro、Okamoto Ryuichi、Watanabe Mamoru、Yui Shiro
    • Journal Title

      Journal of Gastroenterology

      Volume: 58 Issue: 4 Pages: 379-393

    • DOI

      10.1007/s00535-023-01959-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08048, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-23K07394, KAKENHI-PROJECT-22K19519, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-23K27578
  • [Journal Article] Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids2022

    • Author(s)
      Takahashi Junichi、Mizutani Tomohiro、Sugihara Hady Yuki、Nagata Sayaka、Kato Shu、Hiraguri Yui、Takeoka Sayaka、Tsuchiya Mao、Kuno Reiko、Kakinuma Sei、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Cell Reports Methods

      Volume: 2 Issue: 11 Pages: 100337-100337

    • DOI

      10.1016/j.crmeth.2022.100337

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02896
  • [Journal Article] Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation2022

    • Author(s)
      Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S.
    • Journal Title

      Inflammation and Regeneration

      Volume: 42 Issue: 1 Pages: 49-49

    • DOI

      10.1186/s41232-022-00237-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06544, KAKENHI-PROJECT-22K06923, KAKENHI-PROJECT-22K08048, KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02898
  • [Journal Article] Development and Application of Regenerative Medicine in Inflammatory Bowel Disease2022

    • Author(s)
      Okamoto Ryuichi、Mizutani Tomohiro、Shimizu Hiromichi
    • Journal Title

      Digestion

      Volume: 104 Issue: 1 Pages: 24-29

    • DOI

      10.1159/000527423

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-22K19519, KAKENHI-PROJECT-22H00465
  • [Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021

    • Author(s)
      Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
    • Journal Title

      Cell Mol Gastroenterol Hepatol.

      Volume: 11 Issue: 5 Pages: 1483-1503

    • DOI

      10.1016/j.jcmgh.2021.01.014

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898
  • [Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021

    • Author(s)
      Tsuchiya Mao、Ito Go、Hama Minami、Nagata Sayaka、Kawamoto Ami、Suzuki Kohei、Shimizu Hiromichi、Anzai Sho、Takahashi Junichi、Kuno Reiko、Takeoka Sayaka、Hiraguri Yui、Sugihara Hady Yuki、Mizutani Tomohiro、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 542 Pages: 40-47

    • DOI

      10.1016/j.bbrc.2021.01.021

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
  • [Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021

    • Author(s)
      Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 25 Pages: 100906-100906

    • DOI

      10.1016/j.bbrep.2020.100906

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
  • [Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014

    • Author(s)
      Shimizu H, Okamoto R, Ito G, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.
    • Journal Title

      PeerJ

      Volume: 2 Pages: e370-e370

    • DOI

      10.7717/peerj.370

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25860524
  • [Journal Article] Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon2014

    • Author(s)
      Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T
    • Journal Title

      Genes & Development

      Volume: 28(16) Issue: 16 Pages: 1752-1757

    • DOI

      10.1101/gad.245233.114

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-25670106, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PUBLICLY-26112705, KAKENHI-PROJECT-26221307
  • [Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014

    • Author(s)
      N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 454 Issue: 4 Pages: 493-499

    • DOI

      10.1016/j.bbrc.2014.10.091

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
  • [Journal Article] Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells2014

    • Author(s)
      Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 443 Issue: 3 Pages: 840-846

    • DOI

      10.1016/j.bbrc.2013.12.061

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
  • [Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells.2013

    • Author(s)
      Ito G, Okamoto R, Nakamura T, Watanabe M et al
    • Journal Title

      PloS One.

      Volume: 8 Issue: 11 Pages: e79693-e79693

    • DOI

      10.1371/journal.pone.0079693

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524
  • [Presentation] 炎症性腸疾患に対する再生医療2023

    • Author(s)
      岡本隆一,水谷知裕, 清水寛路, 永田紗矢香, 平栗優衣, 杉原ハディ優樹, 加藤周, 髙橋純一, 福田将義, 大塚和明
    • Organizer
      第22回日本再生医療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02895
  • [Presentation] 炎症性腸疾患に対する再生医療の現状2023

    • Author(s)
      清水 寛路, 水谷 知裕, 岡本 隆一
    • Organizer
      第109回消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-22H00465
  • [Presentation] A suspension method for efficient induction and maturation of human intestinal organoids using a rotational bioreactor.2023

    • Author(s)
      Junichi Takahashi, Tomohiro Mizutani, Ryuichi Okamoto
    • Organizer
      2023 RIKEN BDR-CuSTOM Joint Organoid Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02895
  • [Presentation] オルガノイドによる腸組織再生医療のアプローチ2023

    • Author(s)
      水谷知裕, 髙橋純一, 杉原ハディ優樹, 加藤周, 永田紗矢香, 渡辺守, 岡本隆一
    • Organizer
      第22回日本再生医療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02895
  • [Presentation] Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation.2014

    • Author(s)
      Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Ichinose S, Watanabe M, Nakamura T.
    • Organizer
      ISSCR 12th Annual Meeting
    • Place of Presentation
      Vancouver,Canada
    • Year and Date
      2014-06-19
    • Data Source
      KAKENHI-PROJECT-25860524
  • [Presentation] Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation.2014

    • Author(s)
      Mizutani T, Fukuda M, Mochizuki W, Matsumoto T, Nozaki K, Ichinose S, Watanabe M, Nakamura T.
    • Organizer
      DDW2014
    • Place of Presentation
      Chicago,USA
    • Year and Date
      2014-05-03
    • Data Source
      KAKENHI-PROJECT-25860524
  • 1.  岡本 隆一 (50451935)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 2.  根本 泰宏 (20456213)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  森川 亮 (60910122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  福田 将義 (00733627)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  竹中 健人 (10783368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  武部 貴則 (20612625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOFUJI Satoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  中村 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 9.  渡辺 守
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 10.  永石 宇治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  小林 真理子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  土屋 輝一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi