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JINGUSHI KENTARO  神宮司 健太郎

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Jingushi Kentaro  神宮司 健太郎

JINGUSHI Kentaro  神宮司 健太郎

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Researcher Number 80707571
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院薬学研究科, 講師
Affiliation (based on the past Project Information) *help 2022 – 2025: 大阪大学, 大学院薬学研究科, 特任講師(常勤)
2019 – 2021: 大阪大学, 薬学研究科, 特任講師(常勤)
2017: 大阪大学, 医学系研究科, 寄附講座助教
2016: 大阪大学, 大学院薬学研究科・分子細胞生理学, 招へい教員
2013 – 2014: 大阪大学, 薬学研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 47040:Pharmacology-related / Basic Section 56030:Urology-related / Pathological medical chemistry / Biological pharmacy
Except Principal Investigator
Basic Section 56030:Urology-related / Urology
Keywords
Principal Investigator
腎癌 / 腫瘍免疫 / EV抗体 / 癌組織放出細胞外小胞 / 抗癌EV抗体 / 大腸癌 / 癌組織EV / 癌EV / 癌EV抗体 / 細胞外小胞 … More / 癌 / 癌微小環境 / 癌抑制性miRNA / バイオマーカー / エクソソーム / 血清エクソソーム / TGF-β/Smadシグナル伝達経路 / EMT / ccRCC / TGF-bシグナル伝達経路 / miR-629 … More
Except Principal Investigator
腎細胞癌 / 尿路上皮癌 / 細胞外小胞 / エクソソーム / 血液 / 細菌叢 / Dアミノ酸 / CD31 / 血管新生 / Cutibacterium acnes / 制御性T細胞 / Firmicutes / 癌免疫療法 / 細菌関連代謝物 / 血液内細菌叢 / 血液細菌叢 / 腫瘍微小環境 / 腫瘍免疫 / 腫瘍代謝 / Dアラニン / 早期血液診断薬 / Dアミノ酸 / 腎癌組織内免疫 / 血液内細菌情報 / 細菌遺伝情報 / 再発予測因子 / マイクロアレイ解析 / マイクロRNA / miRNA Less
  • Research Projects

    (9 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (12 People)
  •  血液細胞外小胞を基軸とした腸-腫瘍連関メカニズムの解明Principal Investigator

    • Principal Investigator
      神宮司 健太郎
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      The University of Osaka
  •  腎細胞癌局所内免疫状態を構築する血液内細菌叢の同定

    • Principal Investigator
      植村 俊彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Osaka University
  •  尿路上皮癌患者におけるD-アミノ酸発現意義の解明

    • Principal Investigator
      山本 顕生
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Osaka University
  •  Elucidation of the cancer local immune status constructed by the systemic circulating microbiome and bacterial-related metabolism in urogenital cancer

    • Principal Investigator
      河嶋 厚成
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Osaka University
  •  Development of humanized anti-Te-EVs antibody for novel cancer therapyPrincipal Investigator

    • Principal Investigator
      Jingushi Kentaro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Osaka University
  •  Identification and analysis of tumor suppressive miRNAs in RCCPrincipal Investigator

    • Principal Investigator
      Jingushi Kentaro
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Osaka University
  •  血清エクソソームバイオマーカーによる腎癌早期診断実現に向けた研究Principal Investigator

    • Principal Investigator
      神宮司 健太郎
    • Project Period (FY)
      2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  Development of a novel method to analyze cancer-derived circulating exosomes

    • Principal Investigator
      Uemura Motohide
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Osaka University
  •  Analysis of highly expressed miR-629 in clear cell renal cell carcinomaPrincipal Investigator

    • Principal Investigator
      JINGUSHI Kentaro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Biological pharmacy
    • Research Institution
      Osaka University

All 2024 2023 2022 2021 2019 2017 2015 2014 Other

All Journal Article Presentation Patent

  • [Journal Article] Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma2024

    • Author(s)
      Jingushi Kentaro、Kawashima Atsunari、Tanikawa Sayaka、Saito Takuro、Yamamoto Akinaru、Uemura Toshihiro、Sassi Nesrine、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Hase Hiroaki、Nonomura Norio、Tsujikawa Kazutake
    • Journal Title

      Cancer Science

      Volume: 1 Issue: 8 Pages: 1-1

    • DOI

      10.1111/cas.16202

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K24472
  • [Journal Article] Bacteria-derived DNA in serum extracellular vesicles are biomarkers for renal cell carcinoma2023

    • Author(s)
      Uemura Toshihiro、Kawashima Atsunari、Jingushi Kentaro、Motooka Daisuke、Saito Takuro、Nesrine Sassi、Oka Toshiki、Okuda Yohei、Yamamoto Akinaru、Yamamichi Gaku、Tomiyama Eisuke、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Tsujikawa Kazutake、Wada Hisashi、Nonomura Norio
    • Journal Title

      Heliyon

      Volume: 9 Issue: 9 Pages: e19800-e19800

    • DOI

      10.1016/j.heliyon.2023.e19800

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09469, KAKENHI-PROJECT-23K24472
  • [Journal Article] Circulating extracellular vesicles carrying Firmicutes reflective of the local immune status may predict clinical response to pembrolizumab in urothelial carcinoma patients2022

    • Author(s)
      Jingushi Kentaro,Kawashima Atsunari、Saito Takuro、Kanazawa Takayuki、Motooka Daisuke、Kimura Tomonori、Mita Masashi、Yamamoto Akinaru、Uemura Toshihiro、Yamamichi Gaku、Okada Koichi、Tomiyama Eisuke、Koh Yoko、Matsushita Makoto、Kato Taigo、Hatano Koji、Uemura Motohide、Tsujikawa Kazutake、Wada Hisashi、Nonomura Norio
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 71 Issue: 12 Pages: 2999-3011

    • DOI

      10.1007/s00262-022-03213-5

    • Data Source
      KAKENHI-PROJECT-21K20968, KAKENHI-PROJECT-23K24472
  • [Journal Article] Extracellular vesicles isolated from human renal cell carcinoma tissues disrupt vascular endothelial cell morphology via azurocidin2017

    • Author(s)
      Jingushi Kentaro、Uemura Motohide、Ohnishi Naomi、Nakata Wataru、Fujita Kazutoshi、Naito Takuya、Fujii Risa、Saichi Naomi、Nonomura Norio、Tsujikawa Kazutake、Ueda Koji
    • Journal Title

      International Journal of Cancer

      Volume: 142 Issue: 3 Pages: 607-617

    • DOI

      10.1002/ijc.31080

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16KT0116, KAKENHI-PROJECT-17K14999, KAKENHI-PROJECT-26710007, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17K17848
  • [Journal Article] miR-629 Targets TRIM33 to Promote TGFb/Smad Signaling and Metastatic Phenotypes in ccRCC2015

    • Author(s)
      Kentaro Jingushi, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Hiroshi Egawa, Ikumi Ohshio, Ryoji Kawakami, Yuri Kashiwagi, Yohei Tsukada, Takumi Kobayashi, Wataru Nakata, Kazutoshi Fujita, Motohide Uemura, Norio Nonomura, and Kazutake Tsujikawa
    • Journal Title

      Molecular Cancer Research

      Volume: 13 Issue: 3 Pages: 565-574

    • DOI

      10.1158/1541-7786.mcr-14-0300

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25893113
  • [Patent] がん検査方法及びがん治療剤2023

    • Inventor(s)
      辻川和丈、神宮司健太郎
    • Industrial Property Rights Holder
      辻川和丈、神宮司健太郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-107773
    • Filing Date
      2023
    • Acquisition Date
      2023
    • Data Source
      KAKENHI-PROJECT-21K06575
  • [Presentation] Colorectal cancer-derived Te-EVs function as tumor promoter by targeting monocytes via EVs-tRNA2022

    • Author(s)
      Yuya Monoe, Kentaro Jingushi, Yoshiaki Takano, Kohei Taniguchi, Kazumasa Komura, Kazutake Tsujikawa
    • Organizer
      ISEV2022 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06575
  • [Presentation] Colorectal cancer derived Te-EVs function as tumor promoter by targeting monocytes via EVs-RNA2021

    • Author(s)
      Yuya Monoe, Kentaro Jingushi, Yoshiaki Takano, Kohei Taniguchi, Komura Kazumasa, Hiroaki Hase, Kazutake Tsujikawa
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06575
  • [Presentation] 大腸癌放出細胞外小胞に内包されるsmall RNA は単球におけるToll-like Receptor 8を介して腫瘍促進的に働く2021

    • Author(s)
      物江祐弥, 神宮司健太郎, 内藤拓也, 高野義章, 谷口高平, 小村和正, 長谷拓明, 辻川和丈
    • Organizer
      第8回日本細胞外小胞学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K06575
  • [Presentation] 腎癌予後不良性遺伝子群を包括的に標的とする 癌抑制性miRNAの探索と評価2019

    • Author(s)
      服部 功、神宮司 健太郎、長谷 拓明、北惠 郁緒里、上田 裕子、植村 元秀、野々村 祝夫、辻川 和丈
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K18583
  • [Presentation] Glycosylation promotes azurocidin sorting into EVs in clear cell renal cell carcinoma cells.2017

    • Author(s)
      Jingushi K, Naito T, Uemura M, Ueda K, Fujita K, Nonomura N, Tsujikawa K
    • Organizer
      ISEV 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17848
  • [Presentation] 糖鎖修飾はazurocidinのEVへの搭載に重要である2017

    • Author(s)
      神宮司 健太郎、植村 元秀、植田 幸嗣、藤田 和利、河嶋 厚成、氏家 剛、辻川 和丈、野々村 祝夫
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K17848
  • [Presentation] MiR-629 targets TRIM33 to promote TGF-β/Smad signaling in clear cell renal cell carcinoma2014

    • Author(s)
      Kentaro Jingushi, Wataru Nakata, Yuko Ueda, Kaori Kitae, Kazutoshi Fujita, Motohide Uemura, Norio Nonomura, Kazutake Tsujikawa
    • Organizer
      American Association for Cancer Research Annual Meeting 2014
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-25893113
  • [Presentation] 淡明細胞型腎細胞癌においてmiR-629はTRIM33を介してTGF-b/Smadシグナルを促進する

    • Author(s)
      神宮司 健太郎、江川 博、中田 渡、藤田和利、植村 元秀、野々村 祝夫、辻川 和丈
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25893113
  • [Presentation] MiR-629 targets TRIM33 to promote TGF-b/Smad signaling in clear cell renal cell carcinoma

    • Author(s)
      Kentaro Jingushi, Wataru Nakata, Yuko Ueda, Kaori Kitae, Kazutoshi Fujita, Motohide Uemura, Norio Nonomura, Kazutake Tsujikawa
    • Organizer
      AACR annual meeting 2014
    • Place of Presentation
      San Diego Convention Center (San Diego)
    • Year and Date
      2014-04-05 – 2014-04-09
    • Data Source
      KAKENHI-PROJECT-25893113
  • 1.  NONOMURA Norio (30263263)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 6 results
  • 2.  河嶋 厚成 (50746568)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  Uemura Motohide (40631015)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  TSUJIKAWA Kazutake (10207376)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 5.  藤田 和利 (50636181)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 6.  木村 友則 (00631300)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  植村 俊彦 (60905941)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  山本 顕生 (50909653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  元岡 大祐 (10636830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  西塔 拓郎 (20646468)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  和田 尚 (70243459)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  UEDA Koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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