Ikushima Hiroaki 生島弘彬

… Alternative Names

IKUSHIMA Hiroaki 生島弘彬

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Researcher Number	80719154
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2023: 東京大学, 医学部附属病院, 助教 2021 – 2022: 東京大学, 医学部附属病院, 届出研究員 2020: 東京大学, 医学部附属病院, 特任臨床医 2019: 東京大学, 生産技術研究所, 特任助教 2015: 東京大学, 生産技術研究所, 特任助教 2014 – 2015: 東京大学, 生産技術研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / 0903:Organ-based internal medicine and related fields / Immunology Except Principal Investigator Immunology
Keywords	Principal Investigator 肺癌 / 機械学習 / 単一細胞遺伝子発現解析 / リキッドバイオプシー / 自然免疫 / 抗腫瘍免疫 Except Principal Investigator 炎症・がん / DAMP / 免疫原性核酸 / 自己免疫疾患 … More / がん / HMGB1 / 自然免疫受容体 / 炎症 / 自然免疫 / 恒常性維持 / 免疫シグナル伝達 Less

単一細胞遺伝子発現解析の機械学習に基づく腫瘍進展中間段階の解明とモデル化Principal Investigator
- Principal Investigator
  
  生島弘彬
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  The University of Tokyo
Exploration of tissue-specific selective pressure on tumors; integration of time-course analysis by liquid biopsyPrincipal Investigator
- Principal Investigator
  
  IKUSHIMA Hiroaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
- Principal Investigator
  
  Taniguchi Tadatsugu
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Cancer immunosurveillance mediated by innate immune receptorsPrincipal Investigator
- Principal Investigator
  
  Ikushima Hiroaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2015 2014 Other

All Journal Article Presentation Book

[Book] Innate Immune Receptor Signaling and IRF Family of Transcription Factors: Good Deeds and Mis-deeds in Oncogenesis. In Inflammation and Immunity in Cancer (ed. Seya T, Matsumoto M, Udaka K, Sato N)2015
- Author(s)
  Ikushima H, Yanai H, Taniguchi T.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26860316
[Journal Article] Identification of age-dependent features of human bronchi using explainable artificial intelligence2023
- Author(s)
  Ikushima Hiroaki、Usui Kazuhiro
- Journal Title
  
  ERJ Open Research
  
  Volume: 9 Issue: 5 Pages: 00362-2023
- DOI
  10.1183/23120541.00362-2023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08173
[Journal Article] Transdifferentiation of cervical squamous cell carcinoma with ERBB2 amplification to adenocarcinoma: whole genome sequence analysis and successful control by anti-HER2 therapy2023
- Author(s)
  Ikushima Hiroaki、Yamaguchi Kiyoshi、Furukawa Yoichi、Imoto Seiya、Koda Hirotomo、Mizukami Takuro、Morikawa Teppei、Uchino Keita
- Journal Title
  
  BJC Reports
  
  Volume: 1 Issue: 1 Pages: 12-12
- DOI
  10.1038/s44276-023-00015-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08173
[Journal Article] Successful control of intestinal bleeding from metastasis of pulmonary pleomorphic carcinoma with pembrolizumab2022
- Author(s)
  Hiroaki Ikushima, Reina Asaga, Toshio Sakatani, Yoshio Masuda, Teppei Morikawa, Kazuhiro Usui
- Journal Title
  
  Medicine
  
  Volume: 101 Issue: 42 Pages: e31220-e31220
- DOI
  10.1097/md.0000000000031220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08173
[Journal Article] Multidisciplinary Therapy Including Insertion of Two Stents, Photodynamic Therapy, and Nine-line Chemotherapy Against Lung Squamous Cell Carcinoma2021
- Author(s)
  生島弘彬、平石尚久、田宮浩之、天野陽介、鹿毛秀宣、田中剛、佐藤雅昭、松元祐司、土田敬明、長瀬隆英
- Journal Title
  
  The Journal of the Japan Society for Respiratory Endoscopy
  
  Volume: 43 Issue: 5 Pages: 473-479
- DOI
  10.18907/jjsre.43.5_473
- NAID
  130008105738
- ISSN
  0287-2137, 2186-0149
- Year and Date
  2021-09-25
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22918, KAKENHI-PROJECT-21K08173
[Journal Article] Multiple cerebral infarctions in ROS1‐rearranged lung adenocarcinoma2021
- Author(s)
  Ikushima Hiroaki, Hiraishi Yoshihisa, Toriumi Kanto, Ando Takahiro, Tamiya Hiroyuki, Ishida Junichi, Amano Yosuke, Kage Hidenori, Tanaka Goh, Nagase Takahide
- Journal Title
  
  Respirology Case Reports
  
  Volume: 9 Issue: 9
- DOI
  10.1002/rcr2.831
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22918, KAKENHI-PROJECT-21K08173
[Journal Article] Histopathological heterogeneity in an atypical type A thymoma variant with pulmonary metastases2021
- Author(s)
  Yanagiya Masahiro, Horiuchi Hajime, Hiyama Noriko, Matsumoto Jun, Ikushima Hiroaki, Sakatani Toshio, Hara Kei, Morikawa Teppei
- Journal Title
  
  Pathology International
  
  Volume: 71 Issue: 6 Pages: 438-440
- DOI
  10.1111/pin.13089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22918, KAKENHI-PROJECT-21K08173
[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses2015
- Author(s)
  Ikushima H, Taniguchi T.
- Journal Title
  
  Cancer Research
  
  Volume: 75 Issue: 15_Supplement Pages: 4056-4056
- DOI
  10.1158/1538-7445.am2015-4056
- NAID
  40020640495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860316
[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014
- Author(s)
  Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
- Journal Title
  
  eLife
  
  Volume: 04177 Pages: 04177-04177
- DOI
  10.7554/elife.04177
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J04120, KAKENHI-PROJECT-13J05883, KAKENHI-PROJECT-14F04416, KAKENHI-PROJECT-14J04316, KAKENHI-PROJECT-14J12292, KAKENHI-PLANNED-22114007, KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24590574, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-26860316
[Presentation] Meta-analysis of single-cell gene expression data of NSCLC integrated by variational inference and a neural network2024
- Author(s)
  Hiroaki Ikushima
- Organizer
  第21回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] EGFR遺伝子変異陽性肺がん診断時におけるLiquid biopsy の有用性について2023
- Author(s)
  臼井　一裕、吉田　敬士、生島　弘彬、渡邉　かおる、小原　さやか、竹島　英之、酒谷　俊雄
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] Trends in the treatment and the survival of the patients with stage IV non-small cell lung cancer according to the underlying pulmonary diseases, 2002-2021.2023
- Author(s)
  吉田　敬士、竹島　英之、朝賀　玲奈、西村　拓、生島　弘彬、渡邉　かおる、小原　さやか、酒谷　俊雄、臼井　一裕
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] Explainable artificial intelligence (XAI) approach for age-dependent features in bronchoscopy images2023
- Author(s)
  Hiroaki Ikushima
- Organizer
  Asian Pacific Society of Respirology (APSR) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 家屋調査からトリコスポロンを検出した母子同時発症の夏型過敏性肺炎の1例2023
- Author(s)
  生島　弘彬、酒谷　俊雄、吉田　敬士、渡邉　かおる、小原　さやか、竹島　英之、臼井　一裕
- Organizer
  第254回日本呼吸器学会関東地方会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] Schizophyllum commune（スエヒロタケ）によるアレルギー性気管支肺真菌症の一例2023
- Author(s)
  大下　冬馬、小原　さやか、吉田　敬士、生島　弘彬、渡邉　かおる、竹島　英之、酒谷　俊雄、臼井　一裕
- Organizer
  第255回日本呼吸器学会関東地方会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] Explainable AI (XAI) を用いた気管支鏡検査画像からの気管支内腔所見の特徴量抽出2023
- Author(s)
  生島　弘彬、臼井　一裕
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 血胸で発症した胸膜血管肉腫の1例2022
- Author(s)
  仲村　実花子、渡邉　かおる、吉田　敬士、西村　拓、生島　弘彬、小原　さやか、竹島　英之、酒谷　俊雄、臼井　一裕、福元　健人、檜山　紀子、松本　順、増田　芳雄、森川　鉄平
- Organizer
  第251回日本呼吸器学会関東地方会・第182日本結核・非結核性抗酸菌症学会関東支部学会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] Real-world evaluation of the safety and efficacy of mFOLFOX6 for unresectable advanced gastric cancer2022
- Author(s)
  Hiroaki Ikushima, Kazuhiro Usui, Ken Ohata, Tamaki Noie, Nobuyuki Matsuhashi, Keita Uchino
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] Real-world evaluation of the safety and efficacy of mFOLFOX6 for unresectable advanced gastric cancer2022
- Author(s)
  Hiroaki Ikushima, Kazuhiro Usui, Ken Ohata, Tamaki Noie, Nobuyuki Matsuhashi, Keita Uchino
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20K22918
[Presentation] WGS analysis of Erbb2-amplified cervical cancer with two simultaneous histologic types: Transdifferentiation hypothesis2022
- Author(s)
  Hiroaki Ikushima, Keita Uchino, Kiyoshi Yamaguchi, Seiya Imoto, Hirotomo Koda, Takuro Mizukami, Teppei Morikawa, Yoichi Furukawa
- Organizer
  第20回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 非HIV患者におけるニューモシスチス肺炎の予後予測因子の検討2022
- Author(s)
  藤井　洸希、竹島　英之、吉田　敬士、西村　拓、生島　弘彬、渡邉　かおる、小原　さやか、酒谷　俊雄、臼井　一裕
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 単発隆起病変の生検により診断を得た気管・気管支型アミロイドーシスの1例2022
- Author(s)
  藤井　洸希、酒谷　俊雄、吉田　敬士、西村　拓、生島　弘彬、渡邉　かおる、竹島　英之、臼井　一裕
- Organizer
  第45回日本呼吸器内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 肺多形癌小腸転移による小腸出血をペムブロリズマブにてコントロールし得た一例2022
- Author(s)
  朝賀　玲奈、生島　弘彬、酒谷　俊雄、吉田　敬士、西村　拓、渡邉　かおる、小原　さやか、竹島　英之、臼井　一裕
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 喀血を契機に発見された肺放線菌症の一例2022
- Author(s)
  酒谷　俊雄、吉田　敬士、藤井　洸希、西村　拓、渡邉　かおる、生島　弘彬、竹島　英之、福元　健人、檜山　紀子、松本　順、臼井　一裕
- Organizer
  第45回日本呼吸器内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 肺血管拡張を伴った急性好酸球性肺炎の1例2021
- Author(s)
  吉田　敬士、竹島　英之、藤井　洸希、西村　拓、渡邉　かおる、生島　弘彬、小原　さやか、酒谷　俊雄、臼井　一裕
- Organizer
  第246回日本呼吸器学会関東地方会・第180日本結核・非結核性抗酸菌症学会関東支部学会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 肺血管拡張を伴った急性好酸球性肺炎の1例2021
- Author(s)
  吉田　敬士、竹島　英之、藤井　洸希、西村　拓、渡邉　かおる、生島　弘彬、小原　さやか、酒谷　俊雄、臼井　一裕
- Organizer
  第246回日本呼吸器学会関東地方会・第180日本結核・非結核性抗酸菌症学会関東支部学会
- Data Source
  KAKENHI-PROJECT-20K22918
[Presentation] Machine learning-based clustering of scRNAseq data from normal lung tissue and application to lung cancer2021
- Author(s)
  生島弘彬、鹿毛秀宣、長瀬隆英
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20K22918
[Presentation] 確定診断に難渋した結核性リンパ節炎・心膜炎・胸膜炎の1例2021
- Author(s)
  岡崎　俊祐、竹島　英之、吉田　敬士、藤井　洸希、西村　拓、生島　弘彬、渡邉　かおる、酒谷　俊雄、臼井　一裕
- Organizer
  第246回日本呼吸器学会関東地方会・第180日本結核・非結核性抗酸菌症学会関東支部学会
- Data Source
  KAKENHI-PROJECT-21K08173
[Presentation] 確定診断に難渋した結核性リンパ節炎・心膜炎・胸膜炎の1例2021
- Author(s)
  岡崎　俊祐、竹島　英之、吉田　敬士、藤井　洸希、西村　拓、生島　弘彬、渡邉　かおる、酒谷　俊雄、臼井　一裕
- Organizer
  第246回日本呼吸器学会関東地方会・第180日本結核・非結核性抗酸菌症学会関東支部学会
- Data Source
  KAKENHI-PROJECT-20K22918
[Presentation] PDTを含む集学的治療を行い、化学療法9th-lineに至るまでの治療継続を行っている肺扁平上皮癌の一例2020
- Author(s)
  中川紅葉、生島弘彬、宮下直也、平石尚久、田宮浩之、天野陽介、鹿毛秀宣、田中剛、佐藤雅昭、松元祐司、土田敬明、長瀬隆英
- Organizer
  第174回日本呼吸器内視鏡学会関東支部会
- Data Source
  KAKENHI-PROJECT-20K22918
[Presentation] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses2015
- Author(s)
  Ikushima H, Taniguchi T.
- Organizer
  American Association for Cancer Research, Annual Meeting 2015
- Place of Presentation
  Philadelphia (USA)
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860316
[Presentation] Cancer immunosurveillance mediated by innate immune pattern recognition receptors2015
- Author(s)
  Ikushima H.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860316
[Presentation] Recognition of tumor cells by pattern-recognition receptors for anti-tumor innate immune responses
- Author(s)
  生島　弘彬
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  愛媛県
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26860316
[Presentation] Recognition of tumor cells by pattern recognition receptors (PRRs) orchestrates anti-tumor innate immune responses
- Author(s)
  生島　弘彬
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860316
[Presentation] Pattern recognition receptor signaling in anti-tumor immunity
- Author(s)
  Hiroaki Ikushima
- Organizer
  1st Symposium of Max Planck-The University of Tokyo Center for Integrative Inflammology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2014-12-16 – 2014-12-18
- Data Source
  KAKENHI-PROJECT-26860316
[Presentation] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses
- Author(s)
  Hiroaki Ikushima
- Organizer
  FEBS-EMBO Meeting 2014
- Place of Presentation
  Paris, France
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-26860316
[Presentation] がん関連分子パターンの認識による自然免疫受容体活性化を介したがん免疫監視機構
- Author(s)
  生島　弘彬
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  宮城県
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26860316

1. Taniguchi Tadatsugu (50133616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 岩倉洋一郎 (10089120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 西尾純子 (40598679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤尾圭志 (70401114)

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5. 柳井秀元 (70431765)

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6. 根岸英雄 (60514297)

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7. 山本一彦 (80191394)

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Ikushima Hiroaki 生島 弘彬

IKUSHIMA Hiroaki 生島 弘彬

Research Projects

Research Products

Co-Researchers

単一細胞遺伝子発現解析の機械学習に基づく腫瘍進展中間段階の解明とモデル化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of tissue-specific selective pressure on tumors; integration of time-course analysis by liquid biopsyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cancer immunosurveillance mediated by innate immune receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Innate Immune Receptor Signaling and IRF Family of Transcription Factors: Good Deeds and Mis-deeds in Oncogenesis. In Inflammation and Immunity in Cancer (ed. Seya T, Matsumoto M, Udaka K, Sato N)2015

Author(s)

Publisher

Data Source

[Journal Article] Identification of age-dependent features of human bronchi using explainable artificial intelligence2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transdifferentiation of cervical squamous cell carcinoma with ERBB2 amplification to adenocarcinoma: whole genome sequence analysis and successful control by anti-HER2 therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful control of intestinal bleeding from metastasis of pulmonary pleomorphic carcinoma with pembrolizumab2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multidisciplinary Therapy Including Insertion of Two Stents, Photodynamic Therapy, and Nine-line Chemotherapy Against Lung Squamous Cell Carcinoma2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Multiple cerebral infarctions in ROS1‐rearranged lung adenocarcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histopathological heterogeneity in an atypical type A thymoma variant with pulmonary metastases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Meta-analysis of single-cell gene expression data of NSCLC integrated by variational inference and a neural network2024

Author(s)

Ikushima Hiroaki 生島弘彬

IKUSHIMA Hiroaki 生島弘彬