Kunisaki Yuya 国崎祐哉

Researcher Number	80737099
Affiliation (Current)	2025: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 九州大学, 医学研究院, 教授 2019 – 2021: 九州大学, 大学病院, 准教授 2017 – 2019: 九州大学, 大学病院, 講師 2017: 九州大学, 病院, 講師 2016 – 2017: 九州大学, 医学研究院, 助教 2015 – 2016: 九州大学, 医学(系)研究科(研究院), 助教 2014: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Hematology / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 骨髄微小環境 / 造血幹細胞 / 癌微小環境 / 造血器腫瘍 / 間葉系幹細胞 / 白血病 / 微小環境 / 幹細胞 / 加齢 / 造血微小環境 … More / がん幹細胞 / 概日リズム / 腫瘍微小環境 / ニッチ / シングルセル解析 / 癌幹細胞 / 癌 / がん微小環境 / 白血病ニッチ / 白血病幹細胞 / 交感神経 / 光化学技術 / 骨髄環境 / 生体イメージング / ３次元イメージング … More Except Principal Investigator 微小環境 / 白血病幹細胞 / シングルセル遺伝子発現解析 / 組織幹細胞 / 再生医療 / 糖尿病 / 幹細胞ニッチ / 再生医学 / 対称・非対称分裂 / 自己複製分裂 / 機械学習モデル / 人工ニューラルネットワーク / 人工ニッチ / 間葉系幹細胞 / ニッチ分子 / ニッチ / 非対称分裂 / 造血幹細胞 / 白血病幹細胞ニッチ / 血管新生 / 骨芽細胞 / 骨髄造血微小環境 / 癌微小環境 / 血液学 / 幹細胞 / AML / エピゲノム / がん幹細胞 / 代謝 / 自己複製能力 / 骨髄系腫瘍 / シグナル / アミノ酸代謝 / メタボローム / 微小残存病変 / メタボロミクス / 治療抵抗性残存白血病 / TIM-3 Less

膵組織幹細胞のインスリン産生細胞への分化機構とその分化を支持する微小環境の解明
- Principal Investigator
  
  勝田仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kyushu University
Development of novel therapies targeting the interaction between tumor cells and their unique microenvironments for hematological malignanciesPrincipal Investigator
- Principal Investigator
  
  Kunisaki Yuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
Investigation of mechanisms for leukemia developments and progress by single cell profiling of mesenchymal nichesPrincipal Investigator
- Principal Investigator
  
  Kunisaki Yuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
analysis of the regulatory mechanism for the vascular niche to protect leukemia stem cells.
- Principal Investigator
  
  Nakayama Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Medical University
Elucidation of the mechanism of asymmetric division of hematopoietic stem cells using the next-generation artificial niche
- Principal Investigator
  
  Arai Fumio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Elucidation of molecular machineries for the regulation of myeloid leukemia stem cells
- Principal Investigator
  
  AKASHI KOICHI
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
ヒト骨髄性白血病における「静と動」の幹細胞維持・進展メカニズム
- Principal Investigator
  
  赤司浩一
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Mechanisms by which sympathetic nerves regulate functions of hematopoietic stem cell niches by in vivo imaging techniquesPrincipal Investigator
- Principal Investigator
  
  Kunisaki Yuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Roles of functionally disrupted niches on hematological malignancyPrincipal Investigator
- Principal Investigator
  
  Kunisaki Yuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
３次元イメージングによる骨髄造血幹細胞ニッチの同定Principal Investigator
- Principal Investigator
  
  国崎祐哉
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug?induced thromboembolism2024
- Author(s)
  Hatakeyama Kiwamu、Kikushige Yoshikane、Ishihara Daisuke、Yamamoto Shunsuke、Kawano Gentaro、Tochigi Taro、Miyamoto Toshihiro、Sakoda Teppei、Christoforou Andy、Kunisaki Yuya、Fukata Mitsuhiro、Kato Koji、Ito Takumi、Handa Hiroshi、Akashi Koichi
- Journal Title
  
  Blood Advances
  
  Volume: 8 Issue: 3 Pages: 785-796
- DOI
  10.1182/bloodadvances.2023010080
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364
[Journal Article] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis2023
- Author(s)
  Nakashima Kentaro、Kunisaki Yuya、Hosokawa Kentaro、Gotoh Kazuhito、Yao Hisayuki、Yuta Ryosuke、Semba Yuichiro、Nogami Jumpei、Kikushige Yoshikane、Stumpf Patrick S.、MacArthur Ben D.、Kang Dongchon、Akashi Koichi、Ohga Shouichi、Arai Fumio
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/s42003-023-05374-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18301, KAKENHI-PROJECT-23K07861, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K27626
[Journal Article] <scp>GPAM</scp> mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia2023
- Author(s)
  Irifune Hidetoshi、Kochi Yu、Miyamoto Toshihiro、Sakoda Teppei、Kato Koji、Kunisaki Yuya、Akashi Koichi、Kikushige Yoshikane
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 8 Pages: 3247-3258
- DOI
  10.1111/cas.15835
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-23K24364
[Journal Article] Exploring the Role of Desmoplastic Physical Stroma in Pancreatic Cancer Progression Using a Three-Dimensional Collagen Matrix Model2023
- Author(s)
  Song Xiaoyu、Nihashi Yuma、Yamamoto Masamichi、Setoyama Daiki、Kunisaki Yuya、Kida Yasuyuki S.
- Journal Title
  
  Bioengineering
  
  Volume: 10 Issue: 12 Pages: 1437-1437
- DOI
  10.3390/bioengineering10121437
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13919, KAKENHI-PROJECT-21H02950
[Journal Article] Generation of functional oocytes from male mice in vitro2023
- Author(s)
  Murakami Kenta、Hamazaki Nobuhiko、Hamada Norio、Nagamatsu Go、Okamoto Ikuhiro、Ohta Hiroshi、Nosaka Yoshiaki、Ishikura Yukiko、Kitajima Tomoya S.、Semba Yuichiro、Kunisaki Yuya、Arai Fumio、Akashi Koichi、Saitou Mitinori、Kato Kiyoko、Hayashi Katsuhiko
- Journal Title
  
  Nature
  
  Volume: 615 Issue: 7954 Pages: 900-906
- DOI
  10.1038/s41586-023-05834-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-21H02407, KAKENHI-PROJECT-20K21500, KAKENHI-ORGANIZER-18H05544, KAKENHI-PLANNED-18H05545, KAKENHI-PLANNED-18H05549, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-22K19604, KAKENHI-PROJECT-21H02950
[Journal Article] TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia2023
- Author(s)
  Sakoda Teppei、Kikushige Yoshikane、Miyamoto Toshihiro、Irifune Hidetoshi、Harada Takuya、Hatakeyama Kiwamu、Kunisaki Yuya、Kato Koji、Akashi Koichi
- Journal Title
  
  Blood Advances
  
  Volume: - Issue: 10 Pages: 2053-2065
- DOI
  10.1182/bloodadvances.2022008405
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08479, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-23K24364
[Journal Article] A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL.2022
- Author(s)
  Miyawaki K, Kato K, Sugio T, Sasaki K, Miyoshi H, Semba Y, Kikushige Y, Mori Y, Kunisaki Y, Iwasaki H, Miyamoto T, Kuo FC, Aster JC, Ohshima K, Maeda T, Akashi K.
- Journal Title
  
  Blood Adv.
  
  Volume: 6 Issue: 7 Pages: 2388-2402
- DOI
  10.1182/bloodadvances.2021004618
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08818, KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-22K19544, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-20K07381, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-20K17403
[Journal Article] Human acute leukemia utilizes branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function2022
- Author(s)
  Kikushige Yoshikane、Miyamoto Toshihiro、Kochi Yu、Semba Yuichiro、Ohishi Maki、Irifune Hidetoshi、Hatakeyama Kiwamu、Kunisaki Yuya、Sugio Takeshi、Sakoda Teppei、Miyawaki Kohta、Kato Koji、Soga Tomoyoshi、Akashi Koichi
- Journal Title
  
  Blood Advances
  
  Volume: - Issue: 14 Pages: 3592-3603
- DOI
  10.1182/bloodadvances.2022008242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08479, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-20K17403
[Journal Article] Risk factors for late cytomegalovirus infection after completing letermovir prophylaxis2022
- Author(s)
  Mori Yasuo、Harada Takuya、Yoshimoto Goichi、Shima Takahiro、Numata Akihiko、Jinnouchi Fumiaki、Yamauchi Takuji、Kikushige Yoshikane、Kunisaki Yuya、Kato Koji、Takenaka Katsuto、Akashi Koichi、Miyamoto Toshihiro
- Journal Title
  
  International Journal of Hematology
  
  Volume: 116 Issue: 2 Pages: 258-265
- DOI
  10.1007/s12185-022-03348-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364
[Journal Article] Optimization of lymphapheresis for manufacturing autologous CAR-T cells2021
- Author(s)
  Yamanaka Ikumi、Yamauchi Takuji、Henzan Tomoko、Sakoda Teppei、Miyamoto Kyoko、Mishima Hiroyuki、Ono Hiroaki、Koga Yuhki、Nakashima Yasuhiro、Kato Koji、Miyamoto Toshihiro、Mizuno Shinichi、Ogawa Yoshihiro、Ohga Shouichi、Akashi Koichi、Maeda Takahiro、Kunisaki Yuya
- Journal Title
  
  International Journal of Hematology
  
  Volume: 114 Issue: 4 Pages: 449-458
- DOI
  10.1007/s12185-021-03191-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02950
[Journal Article] Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch2021
- Author(s)
  Henzan Tomoko、Yamauchi Takuji、Yamanaka Ikumi、Sakoda Teppei、Semba Yuichiro、Hayashi Masayasu、Kikushige Yoshikane、Mishima Hiroyuki、Ishimura Masataka、Koga Yuhki、Miyamoto Toshihiro、Ohga Shouichi、Akashi Koichi、Maeda Takahiro、Kunisaki Yuya
- Journal Title
  
  International Journal of Hematology
  
  Volume: 114 Issue: 6 Pages: 691-700
- DOI
  10.1007/s12185-021-03207-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-21H02950
[Journal Article] Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45? TER119?Erythroid and Lymphoid Progenitors2020
- Author(s)
  Gotoh Kazuhito、Kunisaki Yuya、Mizuguchi Soichi、Setoyama Daiki、Hosokawa Kentaro、Yao Hisayuki、Nakashima Yuya、Yagi Mikako、Uchiumi Takeshi、Semba Yuichiro、Nogami Jumpei、Akashi Koichi、Arai Fumio、Kang Dongchon
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 11 Pages: 101654-101654
- DOI
  10.1016/j.isci.2020.101654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08733, KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-18K11077, KAKENHI-PROJECT-19K22638
[Journal Article] Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing2020
- Author(s)
  Stumpf Patrick S.、Du Xin、Imanishi Haruka、Kunisaki Yuya、Semba Yuichiro、Noble Timothy、Smith Rosanna C. G.、Rose-Zerili Matthew、West Jonathan J.、Oreffo Richard O. C.、Farrahi Katayoun、Niranjan Mahesan、Akashi Koichi、Arai Fumio、MacArthur Ben D.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 736-746
- DOI
  10.1038/s42003-020-01463-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.2019
- Author(s)
  Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
- Journal Title
  
  Science Advance
  
  Volume: 23 Issue: 1 Pages: 9060-9060
- DOI
  10.1126/sciadv.aau9060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06338, KAKENHI-PROJECT-18K19171, KAKENHI-PLANNED-26119006, KAKENHI-PROJECT-16H04148, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-16J04435, KAKENHI-PROJECT-16KT0175, KAKENHI-PROJECT-19K07288, KAKENHI-PLANNED-17H06350, KAKENHI-PUBLICLY-18H04428, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-16K15193
[Journal Article] Pericytes in Bone Marrow2019
- Author(s)
  Kunisaki Yuya
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 1122 Pages: 101-114
- DOI
  10.1007/978-3-030-11093-2_6
- ISBN
  9783030110925, 9783030110932
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02841
[Journal Article] Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis2019
- Author(s)
  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S., Takakura N.
- Journal Title
  
  Nature Commun,
  
  Volume: 10 Issue: 1 Pages: 1072-1072
- DOI
  10.1038/s41467-019-09028-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04797, KAKENHI-PUBLICLY-18H04897, KAKENHI-PROJECT-16H02470, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-15H05325, KAKENHI-PROJECT-26710005, KAKENHI-PROJECT-19K22553, KAKENHI-PROJECT-19K16742, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-19H05210, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-19H03496
[Journal Article] Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer2018
- Author(s)
  Nakano Michitaka、Kikushige Yoshikane、Miyawaki Kohta、Kunisaki Yuya、Mizuno Shinichi、Takenaka Katsuto、Tamura Shingo、Okumura Yuta、Ito Mamoru、Ariyama Hiroshi、Kusaba Hitoshi、Nakamura Masafumi、Maeda Takahiro、Baba Eishi、Akashi Koichi
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 6 Pages: 780-793
- DOI
  10.1038/s41388-018-0480-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-16H06250, KAKENHI-PROJECT-18H02840
[Journal Article] Identification of unipotent megakaryocyte progenitors in human hematopoiesis.2017
- Author(s)
  K. Miyawaki. Iwasaki, T. Jiromaru, H. Kusumoto, A. Yurino, T. Sugio, Y. Uehara, J. Odawara, S. Daitoku, Y. Kunisaki, Y. Mori, Y. Arinobu, H. Tsuzuki, Y. Kikushige, T. Iino, K. Kato, K. Takenaka, T. Miyamoto, T. Maeda, *K. Akashi
- Journal Title
  
  Blood
  
  Volume: 印刷中 Issue: 25 Pages: 3332-3343
- DOI
  10.1182/blood-2016-09-741611
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-15H04859, KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-16K09897, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-17H01567, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-16H06250, KAKENHI-PROJECT-15K15365, KAKENHI-PROJECT-16K19578
[Journal Article] Differential cytokine contributions of perivascular haematopoietic stem cell niches.2017
- Author(s)
  Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma'ayan A, Frenette PS.
- Journal Title
  
  Nature Cell Biology
  
  Volume: 3 Issue: 3 Pages: 142-223
- DOI
  10.1038/ncb3475
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04859, KAKENHI-PROJECT-15K15364
[Journal Article] Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations.2016
- Author(s)
  A. Yurino, K. Takenaka, T. Yamauchi, T. Nunomura, Y. Uehara, F. Jinnouchi, K. Miyawaki, Y. Kikushige, K. Kato, T. Miyamoto, H. Iwasaki, Y. Kunisaki, *K. Akashi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 7 Issue: 3 Pages: 425-438
- DOI
  10.1016/j.stemcr.2016.07.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-15H04859, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-16H06250, KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-16K09875, KAKENHI-PROJECT-15K15365
[Journal Article] Fetal liver hematopoietic stem cell niches associate with portal vessels2016
- Author(s)
  Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estapé A, Pinho S, Ciero P, Nakahara F, Ma'ayan A, Bergman A, Merad M, Frenette PS.
- Journal Title
  
  Science
  
  Volume: 351 Issue: 6269 Pages: 176-180
- DOI
  10.1126/science.aad0084
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-15H04859
[Journal Article] Cancer stem cells and the niches2015
- Author(s)
  Kunisaki Y.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 73 Pages: 739-744
- Data Source
  KAKENHI-PROJECT-15K15364
[Journal Article] Distinct vascular niches determine hematopoietic stem cell fate2015
- Author(s)
  Kunisaki Y.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 56 Issue: 6 Pages: 606-613
- DOI
  10.11406/rinketsu.56.606
- NAID
  130005093086
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-15H04859
[Journal Article] Cancer stem cells and the niches2015
- Author(s)
  Kunisaki Y.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 73 Pages: 739-744
- Data Source
  KAKENHI-PROJECT-15H04859
[Journal Article] Neutrophil ageing is regulated by the microbiome2015
- Author(s)
  Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang JE, Scheiermann C, Merad M, Frenette PS.
- Journal Title
  
  Nature
  
  Volume: 525 Issue: 7570 Pages: 528-532
- DOI
  10.1038/nature15367
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-15H04859
[Journal Article] Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.2014
- Author(s)
  Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS.
- Journal Title
  
  Nature Medicine
  
  Volume: 20 Issue: 11 Pages: 1315-1320
- DOI
  10.1038/nm.3707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893185
[Journal Article] Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.2014
- Author(s)
  Hanoun M, Zhang D, Mizoguchi T, Pinho S, Pierce H, Kunisaki Y, Lacombe J, Armstrong SA, Dührsen U, Frenette PS.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 4 Issue: 3 Pages: 365-375
- DOI
  10.1016/j.stem.2014.06.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893185
[Journal Article] Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.2014
- Author(s)
  Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS.
- Journal Title
  
  Developmental Cell
  
  Volume: 29 Issue: 3 Pages: 340-349
- DOI
  10.1016/j.devcel.2014.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893185
[Presentation] Imaging of the bone marrow and hematopoietic stem cells2015
- Author(s)
  Yuya Kunisaki
- Organizer
  44th International society of experimental hematology annual meeting
- Place of Presentation
  Kyoto
- Year and Date
  2015-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-15K15364
[Presentation] Imaging of the bone marrow and hematopoietic stem cells2015
- Author(s)
  Yuya Kunisaki
- Organizer
  44th International society of experimental hematology annual meeting
- Place of Presentation
  Kyoto
- Year and Date
  2015-09-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04859
[Presentation] The distinct vascular niches determine hematopoietic stem cell fate
- Author(s)
  Yuya Kunisaki
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪、日本
- Year and Date
  2014-10-30 – 2014-11-01
- Invited
- Data Source
  KAKENHI-PROJECT-26893185
[Presentation] Hematopoietic stem cell niches and haematological neoplasms
- Author(s)
  Yuya Kunisaki
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜、日本
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26893185
[Presentation] Arteriolar niches for hematopoietic stem cells
- Author(s)
  Yuya Kunisaki
- Organizer
  第24回Hot Spring Harbor Symposium
- Place of Presentation
  福岡、日本
- Year and Date
  2014-11-07 – 2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-26893185
[Presentation] NG2+ arteriolar pericytes form niches for dormant hematopoietic stem cells
- Author(s)
  Yuya Kunisaki
- Organizer
  2015 US-Japan Meeting on Malignant Hematopoiesis and Stem Cells
- Place of Presentation
  ハワイ、アメリカ
- Year and Date
  2015-03-16 – 2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26893185
[Presentation] 血管性ニッチによる造血幹細胞制御機構
- Author(s)
  Yuya Kunisaki
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都、日本
- Year and Date
  2014-10-15 – 2014-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-26893185

1. AKASHI KOICHI (80380385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 竹中克斗 (30301295)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 菊繁吉謙 (40619706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. Nakayama Takayuki (00456659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Arai Fumio (90365403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 曽我朋義 (60338217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宮本敏浩 (70343324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 細川健太郎 (90569584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 勝田仁 (50333240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
11. 森康雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 土谷佳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 大澤毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大田浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kunisaki Yuya 国崎 祐哉

Research Projects

Research Products

Co-Researchers

膵組織幹細胞のインスリン産生細胞への分化機構とその分化を支持する微小環境の解明

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Development of novel therapies targeting the interaction between tumor cells and their unique microenvironments for hematological malignanciesPrincipal Investigator

Principal Investigator

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Investigation of mechanisms for leukemia developments and progress by single cell profiling of mesenchymal nichesPrincipal Investigator

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Review Section

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analysis of the regulatory mechanism for the vascular niche to protect leukemia stem cells.

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Elucidation of the mechanism of asymmetric division of hematopoietic stem cells using the next-generation artificial niche

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Elucidation of molecular machineries for the regulation of myeloid leukemia stem cells

Principal Investigator

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ヒト骨髄性白血病における「静と動」の幹細胞維持・進展メカニズム

Principal Investigator

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Mechanisms by which sympathetic nerves regulate functions of hematopoietic stem cell niches by in vivo imaging techniquesPrincipal Investigator

Principal Investigator

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Roles of functionally disrupted niches on hematological malignancyPrincipal Investigator

Principal Investigator

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３次元イメージングによる骨髄造血幹細胞ニッチの同定Principal Investigator

Principal Investigator

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[Journal Article] Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug?induced thromboembolism2024

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[Journal Article] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis2023

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[Journal Article] <scp>GPAM</scp> mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia2023

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[Journal Article] Exploring the Role of Desmoplastic Physical Stroma in Pancreatic Cancer Progression Using a Three-Dimensional Collagen Matrix Model2023

Kunisaki Yuya 国崎祐哉