Tojo Kentaro 東條健太郎

… Alternative Names

TOJO Kentaro 東條健太郎

Less

Researcher Number	80737552
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 横浜市立大学, 医学部, 准教授 2019 – 2023: 横浜市立大学, 医学部, 講師 2017 – 2018: 横浜市立大学, 医学部, 助教 2016: 横浜市立大学, 医学研究科, 特任講師 2015: 横浜市立大学, 附属病院, 指導診療医
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related / Emergency medicine / Anesthesiology Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 55050:Anesthesiology-related / Emergency medicine
Keywords	Principal Investigator 細胞死 / ARDS / 敗血症 / 免疫代謝 / 好中球 / トランスレーショナルリサーチ / 臓器障害 / ネクロプトーシス / アポトーシス / ネクローシス … More / プロリルヒドロキシラーゼ阻害 / 肺傷害 / 代謝リプログラミング / 肺胞上皮細胞 / プロリルヒドロキシラーゼ / 急性呼吸促迫症候群 / 解糖系 / 低酸素誘導性因子 / エネルギー代謝 … More Except Principal Investigator 敗血症 / ARDS / 集中治療 / PICS / 臓器不全 / サルフェン硫黄 / 超硫黄分子 / 硫黄代謝 / 臓器障害 / 周術期医学 / ICU / 集中治療医 / TITIN / エコー / 筋肉 / ICU-AW / インスリン / 肺胞上皮細胞 / 免疫 / 免疫応答 / 肺炎 / 人工呼吸関連肺炎 / せん妄 / 集中治療後症候群 / メタ解析 / 系統的レビュー / 術後睡眠障害 / ラメルテオン / メラトニン / 肺循環 / 肺高血圧症 / 肺高血圧 / アポトーシス / ネクローシス / 細胞死 / 人工呼吸 / 敗血症性多臓器不全 / 敗血症性臓器不全 / 低酸素誘導性因子 / トランスレーショナルリサーチ / メタボロミクス / 細胞代謝 / 急性呼吸促迫症候群 / エネルギー代謝 Less

大侵襲手術後PIICSの実態解明と予防的治療標的同定のための病態解析
- Principal Investigator
  
  後藤隆久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Cell-free RNAを用いた全身の細胞の状態を反映した多臓器障害サブフェノタイピング
- Principal Investigator
  
  菅原陽
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
Can sulfane sulfur protect lung in a mouse model of ARDS by modifying sulfide metabolism?
- Principal Investigator
  
  金丸栄樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
好中球の包括的な免疫代謝解析に立脚した好中球機能の回復による敗血症治療法の開発Principal Investigator
- Principal Investigator
  
  東條健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
肺胞上皮細胞の自然免疫応答を標的とした院内肺炎予防法開発に向けた基盤研究
- Principal Investigator
  
  柏木静
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
敗血症におけるインスリン抵抗性の生物学的意義の解析と治療応用に向けた基盤研究
- Principal Investigator
  
  太田周平
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
Analysis of muscle injury in severe condition focusing on TITIN
- Principal Investigator
  
  中村謙介
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
  Teikyo University
メラトニン/ラメルテオン投与による術後睡眠障害予防効果の検討
- Principal Investigator
  
  水原敬洋
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Exploration of New Therapeutic Targets for Pulmonary Circulatory Dysfunction in ARDS
- Principal Investigator
  
  KANEMARU Eiki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yokohama City University
The trial to elucidate the mechanism underlying PICS after sepsis with stratified metabolome analysis.
- Principal Investigator
  
  GOTO Takahisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Types of alveolar epithlial cell death during ARDS
- Principal Investigator
  
  Uchimoto Kazuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Saitama Children's Medical Center
  Yokohama City University
Role of programmed necrosis in ARDS and the following remote organ injuryPrincipal Investigator
- Principal Investigator
  
  Tojo Kentaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Yokohama City University
Analysis of energy metabolism of injured lung and its application
- Principal Investigator
  
  Ota Shuhei
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Yokohama City University
Hypoxia-Inducible Factor as a Therapeutic Target for Acute Respiratory Distress SyndromePrincipal Investigator
- Principal Investigator
  
  TOJO Kentaro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Analysis of HIF-1 mediated energy metabolism during septic multiple organ dysfunction syndrome
- Principal Investigator
  
  YAMAGUCHI Osamu
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Yokohama City University

All 2024 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Early alveolar epithelial cell necrosis is a potential driver of COVID-19-induced acute respiratory distress syndrome2023
- Author(s)
  Tojo Kentaro、Yamamoto Natsuhiro、Tamada Nao、Mihara Takahiro、Abe Miyo、Nishii Mototsugu、Takeuchi Ichiro、Goto Takahisa
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 1 Pages: 105748-105748
- DOI
  10.1016/j.isci.2022.105748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09146, KAKENHI-PROJECT-21K16575
[Journal Article] 敗血症Up-to-date 敗血症性ARDS研究Up-to-date:基礎・トランスレーショナル研究からわかってきたこと2023
- Author(s)
  東條健太郎
- Journal Title
  
  ICUとCCU
  
  Volume: 47(11) Pages: 725-733
- Data Source
  KAKENHI-PROJECT-22K09146
[Journal Article] 肺胞上皮細胞死からみたARDS2020
- Author(s)
  玉田尚，東條健太郎
- Journal Title
  
  臨床麻酔
  
  Volume: 44 Pages: 535-544
- Data Source
  KAKENHI-PROJECT-17K17062
[Journal Article] Necrosis Rather Than Apoptosis is the Dominant form of Alveolar Epithelial Cell Death in Lipopolysaccharide-Induced Experimental Acute Respiratory Distress Syndrome Model2020
- Author(s)
  Tamada Nao、Tojo Kentaro、Yazawa Takuya、Goto Takahisa
- Journal Title
  
  Shock
  
  Volume: 54 Issue: 1 Pages: 128-139
- DOI
  10.1097/shk.0000000000001425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11582, KAKENHI-PROJECT-17K17062
[Journal Article] Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury2018
- Author(s)
  Tojo Kentaro、Tamada Nao、Nagamine Yusuke、Yazawa Takuya、Ota Shuhei、Goto Takahisa
- Journal Title
  
  The FASEB Journal
  
  Volume: 32 Issue: 4 Pages: 2258-2268
- DOI
  10.1096/fj.201700888r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11414, KAKENHI-PROJECT-15K08360, KAKENHI-PROJECT-15K20054
[Journal Article] Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand-Induced Apoptosis and Lung Injury in Mice2016
- Author(s)
  Yusuke Nagamine, Kentaro Tojo, Takuya Yazawa, Shunsuke Takaki, Yasuko Baba, Takahisa Goto, Kiyoyasu Kurahashi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 55 Issue: 6 Pages: 878-888
- DOI
  10.1165/rcmb.2015-0266oc
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20054
[Presentation] これからは基礎研究の時代!? 集中治療領域における実験生物学的アプローチの実践2024
- Author(s)
  東條健太郎
- Organizer
  第51回日本集中治療医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09146
[Presentation] ARDSにおける過剰炎症の謎:肺胞上皮細胞のネクローシスを起点とした炎症増幅機構2024
- Author(s)
  東條健太郎
- Organizer
  第51回日本集中治療医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09146
[Presentation] 敗血症性ショックの初期蘇生における早期血管収縮薬投与がもたらす生物学的影響の実験的検討2023
- Author(s)
  杜紗矢香，山本夏啓，伊藤慎也，東條健太郎
- Organizer
  第50回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09146
[Presentation] ICU 急性期の筋肉量減少と長期生存の関係―クレアチニン産生量を用いた解析2023
- Author(s)
  山本夏啓，東條健太郎，水原敬洋，後藤隆久
- Organizer
  第50回日本集中治療医学会総会
- Data Source
  KAKENHI-PROJECT-19H03753
[Presentation] 敗血症が筋力，及びマイオカイン遺伝子発現に与える経時的影響の解析:モデルマウスを用いた検討2023
- Author(s)
  山下真，山本夏啓，新倉怜，東條健太郎
- Organizer
  第50回日本集中治療医学会総会
- Data Source
  KAKENHI-PROJECT-19H03753
[Presentation] 肺高血圧症がARDS病態に与える影響についての動物モデルを用いた実験的検討2022
- Author(s)
  安達健雄，東條健太郎，奥真哉，金丸栄樹，菅原陽，後藤隆久
- Organizer
  第49回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09422
[Presentation] 高容量換気はARDSにおける肺胞上皮細胞ネクローシスを増強する2020
- Author(s)
  鶴雄斗，玉田尚，東條健太郎，後藤隆久
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11582
[Presentation] ARDSにおける肺胞上皮細胞死はアポトーシスorネクローシス？-LPS誘導性ARDSモデルを用いた検討-2019
- Author(s)
  玉田尚，東條健太郎，後藤隆久
- Organizer
  第46回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11582
[Presentation] Necrosis rather than apoptosis is the dominant type of alveolar epithelial cell death in LPS-induced experimental ARDS2019
- Author(s)
  Tamada Nao, Tojo Kentaro, Goto Takahisa
- Organizer
  39th International Symposium on Intensive Care and Emergency Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11582
[Presentation] 高容量換気はARDSにおける肺胞上皮細胞ネクローシスを増強する2019
- Author(s)
  鶴雄斗，玉田尚，東條健太郎，後藤隆久
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17062
[Presentation] Necrosis, rather than apoptosis, is the dominant type of alveolar epithelial cell death in LPS-induced experimental ARDS2018
- Author(s)
  Nao Tamada, Kentaro Tojo, Takahisa Goto
- Organizer
  39th International Symposium on Intensive Care and Emergency Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11582
[Presentation] Necrosis, rather than apoptosis, is the dominant type of alveolar epithelial cell death in LPS-induced experimental ARDS2018
- Author(s)
  Nao Tmada, Kentaro Tojo, Takahisa Goto
- Organizer
  39th International Symposium on Intensive Care and Emergency Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17062
[Presentation] ARDS における肺胞上皮細胞死はアポトーシス or ネクローシス?:LPS 誘導性 ARDS モデルを用いた検討2018
- Author(s)
  玉田尚，東條健太郎，後藤隆久
- Organizer
  第４６回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17062
[Presentation] ARDS における肺胞上皮細胞死はアポトーシス or ネクローシス?:LPS 誘導性 ARDS モデルを用いた検討2018
- Author(s)
  玉田尚，東條健太郎，後藤隆久
- Organizer
  第４６回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11582
[Presentation] Metabolic reprogramming by inhibition of prolyl hydroxylases protects alveolar epithelial cells from LPS-neutrophil-induced energy derangements and cell death2017
- Author(s)
  Kentaro Tojo, Nao Tamada, Yusuke Nagamine, Shuhei Ota, Takahisa Goto
- Organizer
  Euroanaesthesia 2017, The European Anesthesiology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20054
[Presentation] Prolyl hydroxylase阻害は肺胞上皮細胞の代謝リプログラミングを介してLPS誘導性肺傷害を軽減する2017
- Author(s)
  東條　健太郎，玉田　尚，長嶺　祐介，矢澤　卓也，太田　周平，後藤　隆久
- Organizer
  第６４回日本麻酔科学会総会
- Data Source
  KAKENHI-PROJECT-15K20054
[Presentation] Prolyl hydroxylase阻害は肺胞上皮細胞の代謝リプログラミングを介してLPS誘導性肺傷害を軽減する2017
- Author(s)
  東條健太郎，玉田尚，長嶺祐介，矢澤卓也，太田周平，後藤隆久
- Organizer
  第64回日本麻酔科学会総会
- Data Source
  KAKENHI-PROJECT-16K11414
[Presentation] Metabolic reprogramming by inhibition of prolyl hydroxylases protects alveolar epithelial cells from LPS-neutrophil-induced energy derangements and cell death2017
- Author(s)
  Kentaro Tojo, Nao Tamada, Yusuke Nagamine, Shuhei Ota, Takahisa Goto
- Organizer
  Euroanaesthesia 2017, The European Anesthesiology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11414
[Presentation] The hydroxylase inhibitor dimethyloxallyl glycine protects lung epithelial barriers from LPS-induced injury in mice2016
- Author(s)
  Kentaro Tojo
- Organizer
  Euroanaesthesia 2016
- Place of Presentation
  London, UK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20054
[Presentation] Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand-induced Apoptosis and Lung Injury in Mice2016
- Author(s)
  Yusuke Nagamine, Kentaro Tojo, Takuya Yazawa, Shunsuke Takaki, Yasuko Baba, Takahisa Goto, Kiyoyasu Kurahashi
- Organizer
  ATS International Conference 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20054

1. 高木俊介 (90644823)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 中村謙介 (50466760)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. GOTO Takahisa (00256075)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 水原敬洋 (00637712)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 杉浦悠毅 (30590202)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. Ota Shuhei (20381478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. KANEMARU Eiki (50793494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 宮崎智之 (30580724)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 菅原陽 (00596413)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. YAMAGUCHI Osamu (20174609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Uchimoto Kazuhiro (50710951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 馬場靖子 (80453041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 柳大介 (80638586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 倉橋清泰 (50234539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 窪田和巳 (50728946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 新倉怜 (70760750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 高瀬堅吉 (80381474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 柏木静 (20596150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 下條信威 (20462210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山川一馬 (50597507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 土井研人 (80505892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 川上英良 (30725338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tojo Kentaro 東條 健太郎

TOJO Kentaro 東條 健太郎

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

好中球の包括的な免疫代謝解析に立脚した好中球機能の回復による敗血症治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of programmed necrosis in ARDS and the following remote organ injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hypoxia-Inducible Factor as a Therapeutic Target for Acute Respiratory Distress SyndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Tojo Kentaro 東條健太郎

TOJO Kentaro 東條健太郎

[Presentation] 敗血症性ショックの初期蘇生における早期血管収縮薬投与がもたらす生物学的影響の実験的検討2023

[Presentation] 敗血症が筋力，及びマイオカイン遺伝子発現に与える経時的影響の解析:モデルマウスを用いた検討2023