Hara Satoshi 原聡史

Researcher Number	80739582
Other IDs
Affiliation (Current)	2025: 佐賀大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 佐賀大学, 医学部, 助教 2015 – 2018: 国立研究開発法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Human genetics / System genome science Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator ゲノム編集 / ゲノムインプリンティング / CRISPR/Cas9 / IG-DMR / Dlk1-Dio3ドメイン / Beckwith-Wiedemann症候群 / Igf2-H19 / 2細胞期インジェクション / エピジェネティクス / 遺伝学 / ヒト-マウス配列置換 / ゲノムインプリント … More Except Principal Investigator … More ソトス症候群 / NSD1 / 空間遺伝子発現 / 一細胞マルチオミクス / 核－細胞質間物質輸送 / 不妊症 / Importin / 配偶子形成 / クロマチン / インポーティン / 核輸送 / 卵 / 女性不妊症 / 精子細胞形成 Less

Elucidation of molecular pathogenesis and establishment of therapeutic foundations for intellectual disabilities based on single-cell multiomics and spatial gene expression
- Principal Investigator
  
  副島英伸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Saga University
Investigation of molecular mechanisms for overgrowth and aberrant hypermethylation using H19-ICR mutant mouse panelPrincipal Investigator
- Principal Investigator
  
  原聡史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Saga University
Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism
- Principal Investigator
  
  宮本洋一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Exploration of the responsible sequence causing perinatal lethality in mice with maternal deletion of IG-DMRPrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Saga University
Regulatory mechanisms of human IG-DMR in knock-in micePrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  National Center for Child Health and Development
Mechanisms of DNA repair involved in the genome editing efficiencies in mouse zygotesPrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  National Center for Child Health and Development

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse<i>Dlk1</i>-<i>Dio3</i>domain2021
- Author(s)
  Hara Satoshi、Terao Miho、Tsuji-Hosokawa Atsumi、Ogawa Yuya、Takada Shuji
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 7 Pages: 564-574
- DOI
  10.1093/hmg/ddab071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06451
[Journal Article] Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith?Wiedemann syndrome2021
- Author(s)
  Sun Feifei、Hara Satoshi、Tomita Chiyoko、Tanoue Yuka、Yatsuki Hitomi、Higashimoto Ken、Soejima Hidenobu
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 185 Issue: 10 Pages: 3062-3067
- DOI
  10.1002/ajmg.a.62364
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06451, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451
[Journal Article] Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method2019
- Author(s)
  Hara Satoshi、Terao Miho、Muramatsu Akari、Takada Shuji
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 20202-20202
- DOI
  10.1038/s41598-019-56676-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06451
[Journal Article] A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1/Dio3 domain during embryonic development.2018
- Author(s)
  Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H and Takada S.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 27 Issue: 18 Pages: 3283-3292
- DOI
  10.1093/hmg/ddy235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664, KAKENHI-PROJECT-17K18403
[Presentation] マウスIG-DMRの母方アレルにおけるインプリント制御領域のスクリーニング2021
- Author(s)
  原聡史、村松あかり、寺尾美穂、高田修治
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K06451
[Presentation] マウスIG-DMRの母方アレルにおけるインプリント制御領域のスクリーニング2020
- Author(s)
  原聡史、村松あかり、寺尾美穂、高田修治
- Organizer
  第113回日本繁殖生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06451
[Presentation] 2細胞期胚へのインジェクションによるインプリント制御領域IG-DMRへのゲノム編集2019
- Author(s)
  原聡史、寺尾美穂、村松あかり、高田修治
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06451
[Presentation] ヒト-マウス間におけるIG-DMRによるインプリント制御機構の違い2018
- Author(s)
  原聡史、高田修治
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K18403
[Presentation] 欠失および配列置換マウスを用いたIG-DMRによる発現制御機構の解析2018
- Author(s)
  原聡史、村松あかり、高田修治
- Organizer
  第111回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-17K18403
[Presentation] 配列置換マウスを用いたDlk1-Dio3領域におけるインプリント制御配列の機能解析2017
- Author(s)
  原聡史、齋藤剛志、高田修治
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K18403

1. 宮本洋一 (10379084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 岡田由紀 (60546430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小井土大 (40787561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 副島英伸 (30304885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 首浦武作志 (20827977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤朋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Satoshi 原 聡史

Research Projects

Research Products

Co-Researchers

Elucidation of molecular pathogenesis and establishment of therapeutic foundations for intellectual disabilities based on single-cell multiomics and spatial gene expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of molecular mechanisms for overgrowth and aberrant hypermethylation using H19-ICR mutant mouse panelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of the responsible sequence causing perinatal lethality in mice with maternal deletion of IG-DMRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of human IG-DMR in knock-in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of DNA repair involved in the genome editing efficiencies in mouse zygotesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse<i>Dlk1</i>-<i>Dio3</i>domain2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith?Wiedemann syndrome2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1/Dio3 domain during embryonic development.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] マウスIG-DMRの母方アレルにおけるインプリント制御領域のスクリーニング2021

Author(s)

Organizer

Data Source

[Presentation] マウスIG-DMRの母方アレルにおけるインプリント制御領域のスクリーニング2020

Author(s)

Organizer

Data Source

[Presentation] 2細胞期胚へのインジェクションによるインプリント制御領域IG-DMRへのゲノム編集2019

Author(s)

Organizer

Data Source

[Presentation] ヒト-マウス間におけるIG-DMRによるインプリント制御機構の違い2018

Author(s)

Organizer

Data Source

[Presentation] 欠失および配列置換マウスを用いたIG-DMRによる発現制御機構の解析2018

Author(s)

Organizer

Data Source

Hara Satoshi 原聡史