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Okada Yuki  岡田 由紀

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OKADA Yuki  岡田 由紀

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Researcher Number 60546430
Other IDs
Affiliation (Current) 2022: 東京大学, 定量生命科学研究所, 教授
Affiliation (based on the past Project Information) *help 2018 – 2022: 東京大学, 定量生命科学研究所, 教授
2018 – 2019: 東京大学, 定量生命科学研究所, 准教授
2011 – 2017: 東京大学, 分子細胞生物学研究所, 准教授
2015: 東京大学, 分子細胞生物学研究所, 特任准教授
2010: 京都大学, 生命科学系キャリアパス形成ユニット, 助教
2010: 東京大学, 分子細胞生物学研究所, 特任准教授
Review Section/Research Field
Principal Investigator
Biological Sciences / Experimental pathology / Biology of Cells to Organisms, and related fields / Basic Section 43010:Molecular biology-related / Transformative Research Areas, Section (III)
Except Principal Investigator
Biological Sciences / Experimental pathology / Transformative Research Areas, Section (III) / Medium-sized Section 48:Biomedical structure and function and related fields
Keywords
Principal Investigator
エピゲノム / クロマチン / 精子クロマチン / 初期胚発生 / リプログラミング / 精子 / 男性不妊 / ATAC-seq / 発生生物学 / ゲノム … More / リモデリング / クロマチンダイナミクス / ChIP-seq / 受精卵 / 転写 / ゲノムアダプテーション / ストレス / 染色体構造 / 遺伝 / エピドラッグ / 白血病 / ペプチドライブラリ / ヒストンメチル化 / トランスレーショナルリサーチ / 癌 / 遺伝子 / スクリーニング / クロマチン構造 / 全能性 / 初期胚 / エピジェネティクス / 経世代効果 / 切断型ヒストン / 精子形成 / XY body / 精子残存ヒストン / 精子特異的ヒストン切断 / 精子ヒストン / クロマチン凝縮 / in vitro再構成 / プロタミン / CUT&Tag / ヒト精子 / シングルセル解析 / ChIL-seq / マスサイトメトリー … More
Except Principal Investigator
染色体 / ゲノム / エピゲノム / エピジェネティクス / 精子形成 / ヒストンメチル化酵素 / 染色体適応 / ゲノムアダプテーション / 減数分裂 / 生殖細胞 / 環境ストレス / 組換え / ゲノム解析 / 相同組換え / シナプトネマ複合体 / コヒーシン / 染色体構造 / 転写制御 / アセチル化 / ゲノム構造制御 / 希少疾患 / 染色体構築 / 染色体動態 / 発現制御 / 発生・分化 / 生体生命情報学 / ゲノム高次構造 / 染色体構築原理 / DNA物性 / 配偶子形成 / Importin / 不妊症 / 核-細胞質間物質輸送 Less
  • Research Projects

    (11 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (37 People)
  •  Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism

    • Principal Investigator
      宮本 洋一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Genome modality: understanding physical properties of the genome

    • Principal Investigator
      西山 朋子
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Nagoya University
  •  Genome modality in germ cells and its implications in diseasesPrincipal Investigator

    • Principal Investigator
      岡田 由紀
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokyo
  •  シングルセル解析によるヒト精子エピゲノムプロフィール多様性の検討Principal Investigator

    • Principal Investigator
      岡田 由紀
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Investigating the function and transgenerational effects of sperm-retained histonesPrincipal Investigator

    • Principal Investigator
      岡田 由紀
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      The University of Tokyo
  •  Qualitative analyses of totipotency-related chromatin structurePrincipal Investigator

    • Principal Investigator
      Okada Yuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Biology of Cells to Organisms, and related fields
    • Research Institution
      The University of Tokyo
  •  4D Chromosome structural information during differentiation

    • Principal Investigator
      Shirahige Katsuhiko
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of PPIs for a histone methyltransferase for leukemia therapyPrincipal Investigator

    • Principal Investigator
      OKADA YUKI
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      The University of Tokyo
  •  Systematic understanding of genome adaptation

    • Principal Investigator
      SHINOHARA Akira
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Understanding the "genome adaptation" in fertilized embryoPrincipal Investigator

    • Principal Investigator
      OKADA Yuki
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Analysis on the roles of DOT1L histone methyltransferase in spermatogenesis

    • Principal Investigator
      MAKINO Yoshinori
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyoto University

All 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Book

  • [Book] 実験医学特集「世代を超えるエピゲノム」2021

    • Author(s)
      岡田由紀
    • Total Pages
      6
    • Publisher
      羊土社
    • ISBN
      9784758125420
    • Data Source
      KAKENHI-PUBLICLY-19H05254
  • [Journal Article] Sperm chromatin structure: Insights from in vitro to in situ experiments.2022

    • Author(s)
      Yuki okada
    • Journal Title

      Current Opinion in Cell Biology

      Volume: 75

    • DOI

      10.1016/j.ceb.2022.102075

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05939
  • [Journal Article] Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions2018

    • Author(s)
      Yamaguchi K, Hada M, Fukuda Y, Inoue E, Makino Y, Katou Y, Shirahige K, Okada Y.
    • Journal Title

      Cell Reports

      Volume: 23(13) Pages: 3920-3932

    • DOI

      10.1016/j.celrep.2018.05.094

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-INTERNATIONAL-15K21761, KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05976, KAKENHI-PROJECT-17J09467, KAKENHI-PROJECT-18J00122
  • [Journal Article] Identification of a variant-specific phosphorylation of TH2A during spermiogenesis.2017

    • Author(s)
      Hada M, Masuda K, Yamaguchi K, Shirahige K, Okada Y.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 46228-46228

    • DOI

      10.1038/srep46228

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-15H05970, KAKENHI-INTERNATIONAL-15K21761, KAKENHI-PLANNED-15H05976
  • [Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.2017

    • Author(s)
      Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
    • Journal Title

      Cell Report

      Volume: 18(3) Pages: 593-600

    • DOI

      10.1016/j.celrep.2016.12.065

    • NAID

      120006957416

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05976, KAKENHI-PUBLICLY-16H01219, KAKENHI-PUBLICLY-16H01550, KAKENHI-PUBLICLY-16H01577, KAKENHI-PLANNED-25112007, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15J06922, KAKENHI-PROJECT-16J09361, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-15K18457, KAKENHI-PROJECT-16K08748, KAKENHI-PROJECT-16K18473, KAKENHI-PROJECT-16K18479, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16K07099, KAKENHI-PUBLICLY-16H01319, KAKENHI-PROJECT-17J06605
  • [Journal Article] Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond.2017

    • Author(s)
      Okada Y, Yamaguchi K
    • Journal Title

      Cell Mol Life Sci.

      Volume: -

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05976
  • [Journal Article] Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages.2015

    • Author(s)
      Yoshida K, Renard-Guillet C, Inoue K, Shirahige K, Okada-Hatakeyama M, Ishii S.
    • Journal Title

      Genomics Data

      Volume: 7 Pages: 90-1

    • DOI

      10.1016/j.gdata.2015.11.028

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-INTERNATIONAL-15K21761, KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05976, KAKENHI-PROJECT-26291006
  • [Journal Article] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory2015

    • Author(s)
      Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Ishibashi K,Chatton B, Inoue K, Uchiyama T, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.
    • Journal Title

      Nat. Immunol.

      Volume: 16(10) Pages: 1034-1043

    • DOI

      10.1038/ni.3257

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05976, KAKENHI-PROJECT-25460377, KAKENHI-PROJECT-26291006
  • [Journal Article] Paternal H3K4 methylation is essential for minor zygotic gene activation and early embryonic development2015

    • Author(s)
      K. Aoshima, E. Inoue, H. Sawa, and Y. Okada
    • Journal Title

      EMBO Reports

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-22125001
  • [Journal Article] Paternal H3K4 methylation is essential for minor zygotic gene activation and early embryonic development2015

    • Author(s)
      Keisuke Aoshima, Erina Inoue, Hirofumi Sawa, Yuki Okada
    • Journal Title

      EMBO reports

      Volume: -

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22125007
  • [Journal Article] The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.2015

    • Author(s)
      Shu-Ting Chen, Maiko Okada, Ryuichiro Nakato, Kosuke Izumi, Masashige Bando and Katsuhiko Shirahige
    • Journal Title

      J Biol Chem.

      Volume: 290 Pages: 21713-21723

    • DOI

      10.1074/jbc.m114.628255

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18465, KAKENHI-PUBLICLY-15H01347, KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05976, KAKENHI-PUBLICLY-26102741, KAKENHI-PROJECT-15H02369, KAKENHI-PROJECT-25290065
  • [Journal Article] ヒストン制御とエピジェネティクス2014

    • Author(s)
      羽田政司、岡田由紀
    • Journal Title

      生体の科学

      Volume: 65

    • Data Source
      KAKENHI-PLANNED-22125007
  • [Journal Article] Generation of a dual-color reporter mouse line to monitor spermatogenesis in vivo2014

    • Author(s)
      Yoshinori Makino, Erina Inoue, Masashi Hada, Keisuke Aoshima, Satsuki Kitano, Hitoshi Miyachi and Yuki Okada
    • Journal Title

      Front Cell Dev Biol.

      Volume: 2 Pages: 1-9

    • DOI

      10.3389/fcell.2014.00030

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J10178, KAKENHI-PLANNED-22125007
  • [Journal Article] Establishment of Alternative Culture Method for Spermatogonial Stem Cells Using Knockout Serum Replacement2013

    • Author(s)
      Aoshima K, Baba A, Makino Y, Okada Y.
    • Journal Title

      PLoS ONE

      Volume: 8-10

    • DOI

      10.1371/journal.pone.0077715

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J01051, KAKENHI-PLANNED-22125007
  • [Journal Article] マウス受精卵前核期におけるクロマチンダイナミクス2013

    • Author(s)
      青島圭佑、岡田由紀
    • Journal Title

      生化学

      Volume: 85-4 Pages: 278-283

    • NAID

      10031169571

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22125007
  • [Journal Article] Understanding paternal genome demethylation through live-cell imaging and siRNA2011

    • Author(s)
      Kazuo Yamagata, Yuki Okada
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 68(10) Pages: 1669-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22125007
  • [Presentation] Investigation of human sperm chromatin heterogeneity and sperm quality using ATAC-seq2021

    • Author(s)
      岡田由紀
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-20H05939
  • [Presentation] ATAC-seq法およびCUT&TAG法を用いたヒト精子エピゲノムプロフィールの解析2021

    • Author(s)
      牧野吉倫、中戸隆一郎、有馬隆博、鈴木譲、兼子智、岡田由紀
    • Organizer
      第14回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PUBLICLY-19H05254
  • [Presentation] 精子クロマチンの操作と測定2021

    • Author(s)
      岡田由紀
    • Organizer
      第59回生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05939
  • [Presentation] ヒト精子におけるエピゲノムプロフィールの検討2020

    • Author(s)
      岡田由紀、牧野吉倫
    • Organizer
      第93回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-19H05254
  • [Presentation] Sperm epigenomics for quantitative analyses of their heterogeneity2020

    • Author(s)
      岡田由紀、牧野吉倫
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PUBLICLY-19H05254
  • [Presentation] 精子におけるN末端テイル切断型ヒストンH3の切断部位とそのゲノム局在の同定2019

    • Author(s)
      岸本 かの子、牧野 吉倫、根岸 瑠美、岡田 由紀
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02369
  • [Presentation] NPMを用いた精子残存ヒストンの再評価と加齢性変化の検討2018

    • Author(s)
      岡田由紀
    • Organizer
      第49回 精子研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-15H05976
  • [Presentation] マウス受精卵前核期におけるクロマチンダイナミクスの解析2013

    • Author(s)
      青島圭佑、岡田由紀
    • Organizer
      第36回分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PLANNED-22125007
  • [Presentation] 受精卵のゲノムアダプテーションの理解2012

    • Author(s)
      岡田由紀
    • Organizer
      新学術領域「ゲノムアダプテーションのシステム的理解」H24班会議
    • Place of Presentation
      東京大学 山上会館
    • Year and Date
      2012-07-04
    • Data Source
      KAKENHI-PLANNED-22125007
  • [Presentation] Investigation of the role of H3K79 Methylation in Spermatogonial Stem Cells2011

    • Author(s)
      岡田由紀
    • Organizer
      CDB symposium 2011
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PLANNED-22125007
  • [Presentation] DOT1L/KMT4, an H3K79 methyltransferase, is required for the mainte nance of spermatogonial stem cells2010

    • Author(s)
      岡田由紀
    • Organizer
      第34回分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PLANNED-22125007
  • 1.  SHIRAHIGE Katsuhiko (90273854)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 2.  MAKINO Yoshinori (60431334)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  SHIRAHIGE Katsuhiko (90501106)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 4.  SHINOHARA Akira (00252578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SUGA HIROAKI (00361668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  石井 俊輔 (00124785)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  井澤 毅 (10263443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  渡邉 日出海 (30322754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  石井 浩二郎 (40360276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  岩崎 博史 (60232659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  永江 玄太 (10587348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  西山 朋子 (90615535)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  前島 一博 (00392118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  瀧ノ上 正浩 (20511249)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  元池 育子 (70347178)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  宮本 洋一 (10379084)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  原 聡史 (80739582)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  小井土 大 (40787561)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  PARK Sung-Joon
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  AOSHIMA Keisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 21.  HADA Masashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  ISOTANI Ayako
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  HORI Tetsuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  OHKAWA Yasuyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  UEDA Jun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  NAKATO Ryuichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  前川 利男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  原田 哲仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  前原 一満
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  胡桃坂 仁志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  山縣 一夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  木村 宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  岩本 隆司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  町田 晋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  坂東 優篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  岡田 麻衣子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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