Ishii Jun 石井順

Researcher Number	80749599
Other IDs
Affiliation (Current)	2025: 獨協医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 獨協医科大学, 医学部, 助教 2015 – 2017: 杏林大学, 医学部, 助教 2015: 杏林大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / Basic Section 49020:Human pathology-related / Human pathology Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 49020:Human pathology-related / Basic Section 49030:Experimental pathology-related / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 細胞増殖 / 肺癌 / 神経内分泌形質 / 内分泌顆粒 / PROX1 / 超微形態学的解析 / 内分泌マーカー / 細胞内オルガネラ / 分化制御 / 内分泌顆粒, secretory granule … More / 抗利尿ホルモン / カルシトニン / H1299細胞 / INSM1 / H1299 / vasopressin / calcitonin / POMC / ホルモン / REST / 3/4型POU遺伝子 / 腫瘍内不均一性 / Delta-Notch / Growth factor / 小細胞肺癌 / 増殖活性 / 増殖因子 / DLK1 / 悪性形質 / マスター遺伝子 / 転写因子 / 甲状腺ホルモン / 転移 / 甲状腺癌 / 内分泌腫瘍 … More Except Principal Investigator 分化 / 肺癌 / 転写因子 / 腺癌 / 形質転換現象 / 神経内分泌癌 / 腫瘍発生 / 希少型 / 細胞分化 / 希少肺腺癌 / リプログラミング / 肝型肺腺癌 / 腸型肺腺癌 / 希少型肺腺癌 / 細胞間接着 / 小細胞癌 / 肺がん / がんの遊走 / がんの増殖 / タイト結合 / クローディン / 小細胞肺癌 / 結節性甲状腺腫 / SLC26A7 / 甲状腺 / ヨウ素貯蔵調節 / 腺腫様甲状腺腫 / Pendrin / SLC26A4 / Isidrin / SLC２6 A4 / ヨウ素輸送蛋白 / 甲状腺濾胞 / 肺癌発生 / 増殖 / RB1遺伝子ファミリー / 神経内分泌肺癌 / agnoprotein / 腫瘍抑制 / PML-NBｓ / JCウイルス / 細胞変性 / 細胞周期 / 脱髄 / PML-NBs / JC virus / 進行性多巣性白質脳症 Less

Analysis of molecular basis in association with transformation from lung adenocarcinoma to neuroendocrine carcinoma
- Principal Investigator
  
  矢澤卓也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Dokkyo Medical University
Elucidation of molecular mechanism that endocrine secretory granule biogenesisPrincipal Investigator
- Principal Investigator
  
  Ishii Jun
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Dokkyo Medical University
The regulatory mechanism of malignant phenotype for small cell lung cancer through the interplay between Claudins
- Principal Investigator
  
  Kashiwagi Korehito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Dokkyo Medical University
Molecular basis of tumorigenesis in pulmonary adenocarcinomas of rare histologic types
- Principal Investigator
  
  Yazawa Hanako
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Dokkyo Medical University
Regulatory mechanism of SLC26A7 and Pendrin in relation to the pathogenesis of multinodular goiter
- Principal Investigator
  
  Kamma Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kyorin University
Molecular basis of neuroendocrine lung carcinogenesis in association with dysfunction of RB1-family proteins
- Principal Investigator
  
  YAZAWA TAKUYA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Dokkyo Medical University
Is DLK gene a trigger for neuroendocrine differentiation of lung cancer?Principal Investigator
- Principal Investigator
  
  Ishii Jun
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Dokkyo Medical University
Progressive multifocal leukoencephalopathy: Dynamics of PML-NBs of JC virus-infected glial cells
- Principal Investigator
  
  Hara Yukiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Medical University
Elucidation of the role of PROX1 gene in endocrine granule formationPrincipal Investigator
- Principal Investigator
  
  Ishii Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Dokkyo Medical University
  Kyorin University

All 2024 2023 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] 肺癌におけるリプログラミング現象2023
- Author(s)
  矢澤(佐藤)華子, 柏木維人, 石井順, 矢澤卓也
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 789-793
- Data Source
  KAKENHI-PROJECT-21K08210
[Journal Article] Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX12022
- Author(s)
  Ishii, J., Sato-Yazawa, H., Kashiwagi, K., Nakadate, K., Iwamoto, M., Kohno, K., Miyata-Hiramatsu, C., Masawa, M., Onozaki, M., Noda, S., Miyazawa, T., Takagi, M., & Yazawa, T.
- Journal Title
  
  Journal of molecular histology
  
  Volume: 10 Issue: 2 Pages: 437-448
- DOI
  10.1007/s10735-021-10055-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06742, KAKENHI-PROJECT-21K16820, KAKENHI-PROJECT-21K06893, KAKENHI-PROJECT-21K08210
[Journal Article] LXRβ activation inhibits proliferation of small cell lung cancer cells through depletion of cellular cholesterol2022
- Author(s)
  Kashiwagi K, Sato-Yazawa H, Ishii J, Kohno K, Tatsuka I, Miyazawa T, Takagi M, Chiba H, Yazawa T
- Journal Title
  
  Anticancer Res
  
  Volume: 42 Issue: 6 Pages: 2923-2930
- DOI
  10.21873/anticanres.15774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06893, KAKENHI-PROJECT-21K08164, KAKENHI-PROJECT-21K08210
[Journal Article] REST inactivation and coexpression of ASCL1 and POU3F4 are necessary for the complete transformation of RB1/TP53-inactivated lung adenocarcinoma into neuroendocrine carcinoma2022
- Author(s)
  Masawa M, Sato-Yazawa H, Kashiwagi K, Ishii J, Miyata-Hiramatsu C, Iwamoto M, Kohno K, Miyazawa T, Onozaki M, Noda S, Shimizu Y, Niho S, Yazawa T
- Journal Title
  
  America Journal of Pathology
  
  Volume: - Issue: 6 Pages: 847-861
- DOI
  10.1016/j.ajpath.2022.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08210, KAKENHI-PROJECT-21K16820, KAKENHI-PROJECT-21K06893
[Journal Article] Histopathological evaluation of the effectiveness of oral Eppikajutsuto treatment for lymphatic malformation2021
- Author(s)
  Matsudera S, Sato-Yazawa H, Terada M, Yamaguchi T, Tani Y, Watanabe S, Kashiwagi K, Ishii J, Ito Y, Ogino K, Okamoto K, Nakajima M, Morita S, Yamaguchi S, Kuroda H, Tsuchioka T, Kojima K, Yazawa T
- Journal Title
  
  Journal of Pediatric Surgery
  
  Volume: 56 Issue: 9 Pages: 1668-1672
- DOI
  10.1016/j.jpedsurg.2020.09.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08210
[Journal Article] Utility of a single particle isolation system in genome-editing and gene-transfection experiments2021
- Author(s)
  Sato-Yazawa H, Kashiwagi K, Ishii J, Masawa M, Onozaki J, Miyata-Hiramatsu C, Miyazawa T, Sakaguchi M, Yazawa T
- Journal Title
  
  Dokkyo Journal of Medical Sciences
  
  Volume: 48 Pages: 75-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08210
[Journal Article] A Punctate Magnetic Resonance Imaging Pattern in a Patient with Systemic Lupus Erythematosus Is an Early Sign of Progressive Multifocal Leukoencephalopathy: A Clinicopathological Study2018
- Author(s)
  Ishii J, Shishido-Hara Y, Kawamoto M, Fujiwara S, Imai Y, Nakamichi K, Kohara N
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 18 Pages: 2727-2734
- DOI
  10.2169/internalmedicine.0696-17
- NAID
  130007484368
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2018-09-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06759, KAKENHI-PROJECT-17K09768
[Journal Article] Two patients with progressive multifocal leukoencephalopathy with immune response against JC virus showing good long-term outcome by combination therapy of mefloquine, mirtazapine, and risperidone2018
- Author(s)
  赤川優美、上野晃弘、池田淳司、石井亘、宍戸-原由紀子、関島良樹
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 58 Issue: 5 Pages: 324-331
- DOI
  10.5692/clinicalneurol.cn-001166
- NAID
  130006744292
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06759
[Journal Article] PROX1 Promotes Secretory Granule Formation in Medullary Thyroid Cancer Cells.2016
- Author(s)
  Ishii J, Yazawa T, Chiba T, Shishido-Hara Y, Arimasu Y, Sato H, Kamma H.
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 3 Pages: 1289-1298
- DOI
  10.1210/en.2015-1973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08408, KAKENHI-PROJECT-15K19056
[Presentation] Claudin-4 regulates the malignant characteristics in small-cell lung cancer cell lines.2024
- Author(s)
  Korehito Kashiwagi, Hanako Sato-Yazawa, Jun Ishii, Tadasuke Miyazawa, Tamotsu Kamimura, Shunsuke Miyata, Hideki Chiba, Takuya Yazawa
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K08164
[Presentation] Investigation of the effect of granule contents on the formation of endocrine granules2024
- Author(s)
  宮澤公輔、宮田隼輔、髙梨歩夢、石井順、矢澤華子、柏木維人、平松千恵、矢澤卓也
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06742
[Presentation] 内分泌顆粒の形成における顆粒内容物質の検討2023
- Author(s)
  宮田隼輔、髙梨歩夢、郷州夏菜、杉山瑠理、宮澤公輔、石井順、矢澤華子、柏木維人、平松千恵、矢澤卓也
- Organizer
  第51回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06742
[Presentation] 内分泌顆粒の形成における顆粒内容物質の検討2023
- Author(s)
  宮田隼輔、髙梨歩夢、郷州夏菜、杉山瑠理、宮澤公輔、石井　順、矢澤華子、柏木維人、平松千恵、矢澤卓也
- Organizer
  第51回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 内分泌顆粒はREST抑制およびPROX1・顆粒内容物質の発現により形成される2023
- Author(s)
  石井　順、矢澤華子、柏木維人、河野　翔、宮澤公輔、平松千恵、小野崎聖人、金野晃大、野田修平、矢澤卓也
- Organizer
  第27回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 分子病理学的解析から見えてくる肺神経内分泌腫瘍の組織発生機序2023
- Author(s)
  矢澤卓也、矢澤華子、柏木維人、石井　順
- Organizer
  第27回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] RB1/TP53不活化肺腺癌細胞はREST不活化と神経特異的転写因子共発現により神経内分泌癌に形質転換する2022
- Author(s)
  矢澤華子、柏木維人、石井　順、河野　翔、小野崎聖人、野田修平、金野晃大、宮澤公輔、矢澤卓也
- Organizer
  第26回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 肺腺癌から神経内分泌癌への形質転換現象に関わる分子メカニズム2021
- Author(s)
  正和明哲, 矢澤華子, 柏木維人, 石井順, 宮澤公輔, 清水泰生, 仁保誠治, 矢澤卓也
- Organizer
  第49回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 肺腺癌細胞への腸上皮マーカーCDX2遺伝子導入に伴う形質変化2021
- Author(s)
  小野崎聖人, 矢澤華子, 柏木維人, 石井順, 平松千恵, 野田修平, 野沢友美, 石田和之, 矢澤卓也
- Organizer
  第49回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] REST遺伝子の抑制およびPROX1、POMC遺伝子の強制発現は非内分泌細胞株H1299に内分泌顆粒様構造物の形成を誘導する2021
- Author(s)
  髙木恵美, 宮澤公輔, 上村　任, 石井　順, 矢澤華子, 柏木維人, 河野翔, 平松千恵, 鈴木盛一朗, 矢澤卓也
- Organizer
  第25回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] REST遺伝子の抑制およびPROX1、POMC遺伝子の強制発現は非内分泌細胞株H1299に内分泌顆粒様構造物の形成を誘導する2021
- Author(s)
  高木恵美、宮澤公輔、上村　任、石井順、矢澤華子、柏木維人、河野翔、平松千恵、鈴木盛一朗、矢澤卓也.
- Organizer
  第25回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06742
[Presentation] 小細胞肺癌細胞の増殖にDLK1が増殖因子を介して関与する可能性について2021
- Author(s)
  石井順, 矢澤華子, 柏木維人, 河野翔, 平松千恵, 鈴木盛一朗, 矢澤卓也
- Organizer
  第25回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 小細胞肺癌細胞集団中のDLK1強陽性細胞は幼若神経マーカーを発現する2020
- Author(s)
  石井順, 矢澤華子, 柏木維人, 平松千恵, 岩本雅美, 正和明哲, 矢澤卓也
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15091
[Presentation] 小細胞肺癌細胞集団中のDLK1強陽性細胞は幼若神経マーカーを発現する2020
- Author(s)
  石井順、矢澤華子、柏木維人、平松千恵、岩本雅美、正和明哲、矢澤卓也
- Organizer
  第109回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15091
[Presentation] REST/PROX1遺伝子発現変化はクロモグラニン高発現細胞を増加させる2020
- Author(s)
  宮澤公輔、辰田功顕、石井　順、矢澤華子、柏木維人、矢澤卓也
- Organizer
  第48回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] REST/PROX1遺伝子発現変化はクロモグラニン高発現細胞を増加させる2020
- Author(s)
  宮澤公輔、辰田功顕、村井　陸、石井　順、矢澤華子、柏木維人、岩本雅美、平松千恵、正和明哲、矢澤卓也
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 硬化性肺上皮腫の遺伝子変異解析2019
- Author(s)
  太田昌幸、河村大輔、矢澤華子、柏木維人、石井順、矢澤卓也、石川俊平、吉野一郎、池田純一郎、中谷行雄
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] Liver X receptor (LXR) βは小細胞肺癌治療の新規標的分子になり得る2019
- Author(s)
  辰田功顕、宮澤公輔、柏木維人、矢澤華子、石井順、岩本雅美、正和明哲、太田昌幸、千葉英樹、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 小細胞肺癌細胞集団におけるDLK1陽性細胞は増殖に寄与する2019
- Author(s)
  石井順、矢澤華子、柏木維人、鈴木盛一朗、平松千恵、岩本雅美、太田昌幸、正和明哲、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 小細胞肺癌細胞集団におけるDLK1陽性細胞は増殖に寄与する2019
- Author(s)
  石井順、矢澤華子、柏木維人、鈴木清一朗、平松千恵、岩本雅美、太田昌幸、正和明哲、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 内分泌顆粒形成を制御する２遺伝子：PROX1およびREST2019
- Author(s)
  内藤美桜、原田慎也、石井順、矢澤華子、柏木維人、鈴木盛一朗、岩本雅美、正和明哲、太田昌幸、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 小細胞肺癌細胞集団におけるDLK1陽性細胞は増殖に寄与する2019
- Author(s)
  石井順、矢澤華子、柏木維人、鈴木盛一郎、平松千恵、岩本雅美、太田昌幸、正和明哲、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15091
[Presentation] RB1ファミリーの活性化が細胞増殖やEMTに及ぼす影響2019
- Author(s)
  正和明哲、矢澤卓也、矢澤華子、石井順、柏木維人、石井芳樹
- Organizer
  第59回日本呼吸器病学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] CDX2遺伝子導入による腸型肺腺癌細胞作製の試み2019
- Author(s)
  谷口有寿佳、坂口舞、江島一志、矢澤華子、石井順、柏木維人、平松千恵、正和明哲、太田昌幸、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] POU3F4およびPOU4F2強制発現に伴い共通して活性化する転写因子HES5の制御による神経内分泌形質の減弱化2018
- Author(s)
  矢澤華子、柏木維人、石井順、平松千恵、菅間博、矢澤卓也
- Organizer
  第22回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] PROX1は甲状腺髄様癌の内分泌顆粒形成に関与する2015
- Author(s)
  石井順、矢澤卓也、千葉知宏、有益優、菅間博
- Organizer
  第19回日本内分泌病理学会学術総会
- Place of Presentation
  佐賀
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-15K19056

1. YAZAWA TAKUYA (50251054)

# of Collaborated Projects: 6 results

# of Collaborated Products: 24 results
2. Yazawa Hanako (60438132)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. Kashiwagi Korehito (50722451)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
4. Kamma Hiroshi (10195191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. Hara Yukiko (40313267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 千葉知宏 (60398617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 平野浩一 (30189849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中里陽子 (60424115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SATO Hanako

# of Collaborated Projects: 0 results

# of Collaborated Products: 28 results

Ishii Jun 石井 順

Research Projects

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Analysis of molecular basis in association with transformation from lung adenocarcinoma to neuroendocrine carcinoma

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Elucidation of molecular mechanism that endocrine secretory granule biogenesisPrincipal Investigator

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The regulatory mechanism of malignant phenotype for small cell lung cancer through the interplay between Claudins

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Molecular basis of tumorigenesis in pulmonary adenocarcinomas of rare histologic types

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Regulatory mechanism of SLC26A7 and Pendrin in relation to the pathogenesis of multinodular goiter

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Molecular basis of neuroendocrine lung carcinogenesis in association with dysfunction of RB1-family proteins

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Is DLK gene a trigger for neuroendocrine differentiation of lung cancer?Principal Investigator

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Progressive multifocal leukoencephalopathy: Dynamics of PML-NBs of JC virus-infected glial cells

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Elucidation of the role of PROX1 gene in endocrine granule formationPrincipal Investigator

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[Journal Article] 肺癌におけるリプログラミング現象2023

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[Journal Article] Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX12022

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[Journal Article] LXRβ activation inhibits proliferation of small cell lung cancer cells through depletion of cellular cholesterol2022

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[Journal Article] REST inactivation and coexpression of ASCL1 and POU3F4 are necessary for the complete transformation of RB1/TP53-inactivated lung adenocarcinoma into neuroendocrine carcinoma2022

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[Journal Article] Histopathological evaluation of the effectiveness of oral Eppikajutsuto treatment for lymphatic malformation2021

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Ishii Jun 石井順