Ono Atsushi 大野敦司

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ONO ATSUSHI 大野敦司

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Researcher Number	80774645
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(医), 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 広島大学, 医系科学研究科(医), 助教 2019 – 2021: 広島大学, 医系科学研究科(医), 助教 2018: 広島大学, 医歯薬保健学研究科(医), 助教 2017: 広島大学, 病院(医), 病院助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50010:Tumor biology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝細胞癌 / バイオマーカー / レンバチニブ / 肝癌 / ベバシズマブ / アテゾリズマブ / がん免疫 / リンパ球 / 免疫療法 / 癌免疫 … More / 微小環境 / 抗PD-L1抗体 / シンジェニックマウスモデル / 腫瘍免疫 / 腫瘍免疫微小環境 / circulating tumor DNA / 血中循環腫瘍DNA / 肝がん / サイトカイン … More Except Principal Investigator 腫瘍免疫 / 空間的RNA解析 / がんゲノム / 肝胆膵がん / ゲノム不安定 / シークエンス解析 / 膵がん / 胆道がん / 空間的発現解析 / ゲノム / 肝臓がん Less

Identification of molecules associated with response to atezolizumab plus bevacizumab therapy in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  大野敦司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Genomic instability and immunology of hepato-biliary cancer
- Principal Investigator
  
  中川英刀
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Institute of Physical and Chemical Research
A Study of the Effect of Lenvatinib on the Immune Microenvironment of Hepatocellular CarcinomaPrincipal Investigator
- Principal Investigator
  
  Atsushi Ono
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hiroshima University
Elucidation of the mechanism of therapeutic resistance in liver cancer using circulating tumor DNAPrincipal Investigator
- Principal Investigator
  
  ONO ATSUSHI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University

All 2024 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma2024
- Author(s)
  Shirane Yuki、Fujii Yasutoshi、Ono Atsushi、Nakahara Hikaru、Hayes Clair Nelson、Miura Ryoichi、Murakami Serami、Sakamoto Naoya、Uchikawa Shinsuke、Fujino Hatsue、Nakahara Takashi、Murakami Eisuke、Yamauchi Masami、Miki Daiki、Kawaoka Tomokazu、Arihiro Koji、Tsuge Masataka、Oka Shiro
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 7 Pages: 1328-1328
- DOI
  10.3390/cancers16071328
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15582, KAKENHI-PROJECT-23K07463
[Journal Article] Association of hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI imaging with immune microenvironment and response to atezolizumab plus bevacizumab treatment.2023
- Author(s)
  Tamura Y, Ono A, Nakahara H, Hayes N, Fujii Y, Zhang P, Yamauchi M, Uchikawa S, Kodama K, Teraoka Y, Fujimo H, Nakahara T, Murakami E, Serikawa M, Miki D, Kawaoka T, Okamoto W, Imamura M, Nakamura Y, Awai T, Ohdan H, Fujita M, Nakagawa H, Chayama K, Aikata H, and Oka S
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 17 Pages: 4234-4234
- DOI
  10.3390/cancers15174234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24324
[Journal Article] The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.2022
- Author(s)
  Zhang P, Ono A, Fujii Y, Hayes CN, Tamura Y, Miura R, Shirane Y, Nakahara H, Yamauchi M, Uchikawa S, Uchida T, Teraoka Y, Fujino H, Nakahara T, Murakami E, Miki D, Kawaoka T, Okamoto W, Makokha GN, Imamura M, Arihiro K, Kobayashi T, Ohdan H, Fujita M, Nakagawa H, Chayama K, and Aikata H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 151 Issue: 12 Pages: 2278-2290
- DOI
  10.1002/ijc.34247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24324
[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022
- Author(s)
  Fujita Masashi、Chen Mei-Ju May、Siwak Doris Rieko、Sasagawa Shota、Oosawa-Tatsuguchi Ayako、Arihiro Koji、Ono Atsushi、Miura Ryoichi、Maejima Kazuhiro、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Lee Ju-Seog、Lu Yiling、Mills Gordon B.、Liang Han、Nishizuka Satoshi S.、Nakagawa Hidewaki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6481-6481
- DOI
  10.1038/s41467-022-34249-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer2022
- Author(s)
  Kiyose Hiroki、Nakagawa Hidewaki、Ono Atsushi、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Shimada Mihoko、Wong Jing Hao、Fujimoto Akihiro
- Journal Title
  
  PLOS Genetics
  
  Volume: 18 Issue: 8 Pages: e1010342-e1010342
- DOI
  10.1371/journal.pgen.1010342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib2020
- Author(s)
  Ono A, Aikata H, Yamauchi M, Kodama K, Ohishi W, Takeshi K, Ohya K, Teraoka Y, Osawa M, Fujino H, Nakahara T, Murakami E, Miki D, Kawaoka T, Abe-Chayama H, Zhang P, Liu S, Makokha , Tsuge M, Imamura M, Hayes CN, Chayama K
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15948
[Presentation] 進行肝細胞癌に対するAtezolizumab+Bevacizumab治療前の末梢T細胞サブポピュレーションの解析～治療効果との関連に着目して～2023
- Author(s)
  白根佑樹、藤井康智、大野敦司、柘植雅貴、岡志郎
- Organizer
  第8回Gastro-PLUS
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] 肝細胞癌に対するatezolizumab+bevacizumab治療効果予測のバイオマーカーとなりうる末梢T細胞サブポピュレーション2023
- Author(s)
  白根佑樹、大野敦司、岡　志郎
- Organizer
  第45回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] Lenvatinib activates potential anti-tumor immunity by increasing infiltration of immune cells and interferon response in tumor microenvironment of advanced hepatocellular carcinoma2022
- Author(s)
  Yamauchi Masami, Atsushi Ono, et al.
- Organizer
  ESMO 24th World Congress on Gastrointestinal Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16332
[Presentation] EXPLORATORY ANALYSIS OF BIOMARKERS ASSOCIATED WITH CLINICAL OUTCOMES OF LENVATINIB IN HEPATOCELLULAR CARCINOMA2019
- Author(s)
  Atsushi Ono, Hiroshi Aikata, Masami Yamauchi, Kenichiro Kodama, Daiki Miki, Waka Ohishi, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Hiromi Abe-Chayama, Masataka Tsuge, Michio Imamura, Clair Nelson Hayes, Kazuaki Chayama
- Organizer
  The Liver Meeting 2019, American Association for the Study of Liver Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15948
[Presentation] 進行肝癌におけるレンバチニブ治療のバイオマーカーの探索2019
- Author(s)
  大野　敦司
- Organizer
  第56回　日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15948
[Presentation] 進行肝癌におけるレンバチニブ治療のバイオマーカーの探索,2019
- Author(s)
  大野　敦司
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15948

1. 中川英刀 (50361621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 中村透 (70645796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 相方浩 (30403512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 山上裕機

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 速水晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山内理海

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ono Atsushi 大野 敦司

ONO ATSUSHI 大野 敦司

Research Projects

Research Products

Co-Researchers

Identification of molecules associated with response to atezolizumab plus bevacizumab therapy in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic instability and immunology of hepato-biliary cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A Study of the Effect of Lenvatinib on the Immune Microenvironment of Hepatocellular CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of therapeutic resistance in liver cancer using circulating tumor DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI imaging with immune microenvironment and response to atezolizumab plus bevacizumab treatment.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib2020

Author(s)

Journal Title

Data Source

[Presentation] 進行肝細胞癌に対するAtezolizumab+Bevacizumab治療前の 末梢T細胞サブポピュレーションの解析 ～治療効果との関連に着目して～2023

Author(s)

Organizer

Data Source

[Presentation] 肝細胞癌に対するatezolizumab+bevacizumab治療効果予測のバイオマーカーとなりうる末梢T細胞サブポピュレーション2023

Author(s)

Organizer

Data Source

[Presentation] Lenvatinib activates potential anti-tumor immunity by increasing infiltration of immune cells and interferon response in tumor microenvironment of advanced hepatocellular carcinoma2022

Author(s)

Organizer

Data Source

[Presentation] EXPLORATORY ANALYSIS OF BIOMARKERS ASSOCIATED WITH CLINICAL OUTCOMES OF LENVATINIB IN HEPATOCELLULAR CARCINOMA2019

Author(s)

Organizer

Data Source

[Presentation] 進行肝癌におけるレンバチニブ治療のバイオマーカーの探索2019

Author(s)

Organizer

Data Source

[Presentation] 進行肝癌におけるレンバチニブ治療のバイオマーカーの探索,2019

Author(s)

Ono Atsushi 大野敦司

ONO ATSUSHI 大野敦司

[Presentation] 進行肝細胞癌に対するAtezolizumab+Bevacizumab治療前の末梢T細胞サブポピュレーションの解析～治療効果との関連に着目して～2023