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Ohashi Akihiro  大橋 紹宏

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Akihiro Ohashi  大橋 紹宏

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Researcher Number 80835249
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Affiliation (based on the past Project Information) *help 2020 – 2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 59040:Nutrition science and health science-related
Keywords
Principal Investigator
ボトルネック効果 / 一細胞解析・空間解析 / fitness cost / CINパラドクス / 染色体不安定性(CIN) / 家族性乳がん・卵巣がん / 新規生殖細胞突然変異 / スプライシング異常 / 5’非翻訳領域に位置する新規BRCA2変異 / 家族性乳癌・卵巣癌症候群(HBOC) … More / 意義不明変異(VUS) / BRCA2 / 新規併用療法の開発戦略 / オミックス統合解析 / DNA損傷反応 / CDC7阻害剤TAK-931 / マルチオミックス解析 / 併用療法戦略 / がん治療薬 / 複製ストレス / TAK-931 / CDC7阻害剤 / 薬効・薬理研究 / バイオマーカー / トランスクリプトーム解析 / 橋渡し研究 / Drug Discovery / 低分子阻害剤 / CDC7キナーゼ / DNA複製ストレス … More
Except Principal Investigator
double nicking / Cas9 / Cancer / Adenovirus vector / Human Papillomavirus / 低分子化合物 / 炎症 / 老化 Less
  • Research Projects

    (5 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (15 People)
  •  Study on the Elucidation of the Cancer Chromosomal Instability (CIN) Paradox and the Development of Novel Therapeutic Strategies Targeting CIN VulnerabilitiesPrincipal Investigator

    • Principal Investigator
      大橋 紹宏
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  Development of an Oncolytic Adenoviral Vector Targeting the Synergistic Effects of HPV Genome-Editing Disruption and Tumor Lysis for Cancer Therapy

    • Principal Investigator
      清野 透
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Sasaki Foundation
  •  Development of preventive and therapeutic strategies for age-related chronic inflammation by targeting senescence-associated T cells

    • Principal Investigator
      錦見 昭彦
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Combination treatment with CDC7 inhibitor and DNA damage agents enhances antiproliferative activity in multiple preclinical modelsPrincipal Investigator

    • Principal Investigator
      Akihiro Ohashi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancerPrincipal Investigator

    • Principal Investigator
      Ohashi Akihiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      National Cancer Center Japan

All 2023 2022 2021

All Journal Article Presentation

  • [Journal Article] Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation2022

    • Author(s)
      Du Junyan、Kageyama Shun‐Ichiro、Yamashita Riu、Hirata Hidenari、Hakozaki Yumi、Okumura Masayuki、Motegi Atsushi、Hojo Hidehiro、Nakamura Masaki、Hirano Yasuhiro、Sunakawa Hironori、Minamide Tatsunori、Kotani Daisuke、Tanaka Kosuke、Yano Tomonori、Kojima Takashi、Ohashi Akihiro、Tsuchihara Katsuya、Akimoto Tetsuo
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 4 Pages: 1352-1361

    • DOI

      10.1111/cas.15297

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08190, KAKENHI-PROJECT-21K07582, KAKENHI-PROJECT-20H03541
  • [Journal Article] A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery2021

    • Author(s)
      Iwai Kenichi、Nambu Tadahiro、Kashima Yukie、Yu Jie、Eng Kurt、Miyamoto Kazumasa、Kakoi Kazuyo、Gotou Masamitsu、Takeuchi Toshiyuki、Kogame Akifumi、Sappal Jessica、Murai Saomi、Haeno Hiroshi、Kageyama Shun-Ichiro、Kurasawa Osamu、Niu Huifeng、Kannan Karuppiah、Ohashi Akihiro
    • Journal Title

      Science Advances

      Volume: 7 Issue: 21 Pages: 0-0

    • DOI

      10.1126/sciadv.abf0197

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Journal Article] Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer2021

    • Author(s)
      Kashima Yukie、Shibahara Daisuke、Suzuki Ayako、Muto Kyoko、Kobayashi Ikei S.、Plotnick David、Udagawa Hibiki、Izumi Hiroki、Shibata Yuji、Tanaka Kosuke、Fujii Masanori、Ohashi Akihiro、Seki Masahide、Goto Koichi、Tsuchihara Katsuya、Suzuki Yutaka、Kobayashi Susumu S.
    • Journal Title

      Cancer Research

      Volume: 81 Issue: 18 Pages: 4835-4848

    • DOI

      10.1158/0008-5472.can-20-2811

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16879, KAKENHI-PROJECT-20H03541
  • [Presentation] CENP-E inhibitors activate cGAS-STING pathway by inducing chromosome misalignment and micronucleation after mitotic slippage2023

    • Author(s)
      大橋 紹宏
    • Organizer
      AACR Annual Meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] CENP-E inhibitor potently activates cGAS-STING pathway through misaligned chromosome-mediated micronucleation after mitotic slippage2022

    • Author(s)
      大橋 紹宏
    • Organizer
      The 34th EORTC-NCI-AACR Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] Property analysis of chromosomal instability adapted cells using multi omics approaches.2021

    • Author(s)
      Morita T.M., Haeno H, Makinoshima H, Suzuki A, Kobayashi S.S. and Ohashi A.
    • Organizer
      AACR Annual meeting, 2021.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] A CDC7-selective inhibitor, TAK-931, induces replication stress-mediated mitotic aberration and leads to antiproliferation in a broad range of cancer cells2021

    • Author(s)
      Akihiro Ohashi
    • Organizer
      The 94th Annual Meeting of the Japanese Biochemical Society 2021
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors2021

    • Author(s)
      Morita T.Y., Yu J., Kashima Y., Tanaka K., Hakozaki Y., Kageyama S., Nakamura A., Lightcap E., Niu H., Kannan K., and Ohashi A.
    • Organizer
      The 32nd EORTC-NCI-AACR symposium, 2021.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cell.2021

    • Author(s)
      Hakozaki Y., Kashima Y., Morita T.Y., Tanaka K, Kobayashi S.S. and Ohashi A.
    • Organizer
      AACR Annual meeting, 2021.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors2021

    • Author(s)
      Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, and Akihiro Ohashi
    • Organizer
      The 44th Annual Meeting of the Molecular Biology Society of Japan., 2021
    • Data Source
      KAKENHI-PROJECT-20H03541
  • [Presentation] Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitors2021

    • Author(s)
      Akihiro Ohashi
    • Organizer
      The 80th Annual Meeting of the Japanese Cancer Association 2021
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03541
  • 1.  鹿島 幸恵 (80831883)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 2.  影山 俊一郎 (60644979)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  小林 進 (70792836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  向原 徹 (80435718)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  桑田 健 (00327321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  堀居 拓郎 (00361387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  錦見 昭彦 (70404019)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  中井 一貴 (21003063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  山下 大生 (40970835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  鎌田 諒 (60801420)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  波江野 洋 (70706754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  清野 透 (10186356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  中西 友子 (10344863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  北條 秀博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  秋元 哲夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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