MARUYAMA Yukio 丸山幸夫

… Alternative Names

丸山幸夫マルヤマユキオ

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Researcher Number	90004712
External Links
Affiliation (based on the past Project Information) *help	1993 – 2005: 福島県立医科大学, 医学部, 教授 1995: 1st.Dept.of Int.Med, Fukushima Medical College, Prof., 医学部・第一内科, 教授 1994: 福島県立医科大学, 医学部・(第一内科), 教授 1993: 福島県立医科大学, 医学部(第一内科), 教授 1992: 福島県立医科大学, 医学部・第一内科, 教授 … More 1991: 1st Dep. Int. Med. Fukushima Medical College, 第一内科, 教授 1988: 東北大学, 医学部, 助教授 1987: 東北大学, 医学部・付属病院, 講師 1986: 東北大, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Hematology / Circulatory organs internal medicine
Keywords	Principal Investigator RhoA / L-arginine / 冠狭窄度 / 圧・心筋長関係 / ラグラジアン・ストレイン / 心内圧関係 / 心筋長 / 左室圧下降時定数 / 心機能 / 拡張期心筋コンプライアンス … More / 二枝狭窄 / 心筋虚血 / 肺血管容量 / 肺血管コンダクタンス / 肺動脈圧 / 肺静脈圧 / 左室拡張末期圧 / 運動負荷 / calcium / NF-κB / plasminogen activator inhibitor-1 / tissue factor / oxidized LDL / monocyteadhesion / geranylgeranylation / endothelial dysfunction / 血管内皮細胞 / 組織因子 / 活性酸素種 / 酸化LDL / eNOS / カルシウム / NF-kB / PAI-1 / ゲラニルゲラニル化 / 単球 / 血管内皮細胞機能不全 / Ion channel / Nitric oxide / Mitochondria / Ischemic heart disease / Ca過負荷 / リモデリング / ラット / 慢性虚血 / 冠動脈狭窄 / 一酸化窒素 / イオンチャネル / 一酸化窒素合成酵素 / ミトコンドリア / 虚血性心疾患 / ACE inhibitor / Nitric Oxide / intimal hyperplasia / PTCA / L-NAME / D-Arginine / L-Arginino / 動脈硬化 / ACE-inhibitor / NO / 内膜肥厚 / 経皮的冠動脈形成術 / 右室肥大 / 一酸化炭素 / 肺高血圧 / 心不全 / ヘムオキシゲナーゼ / 運動負荷モデル / 骨格筋求心線維 / 交感神経活動 / 脊髄電気刺激 / ノルエピネフリン / 心筋酸素消費量 / 冠循環 / 変力作用 / 変時作用 / 交感神経 … More Except Principal Investigator 血管内皮細胞 / heme oxygenase / 酸化ストレス / 動脈硬化 / ヘムオキシゲナーゼ / CD59 / 心不全 / RhoA / macrophage / マクロファージ / Rho / atherosclerosis / bilirubin / 7-AAD / TUNEL / アセチルコリン / 顆粒球 / 発作性夜間血色素尿症(PNH) / CD34陽性細胞 / CD55 / GPIアンカー膜蛋白 / PNH / トロンボポエチン / アポトーシス / 一酸化窒素 / 自律神経 / 非アドレナリン性非コリン性神経 / knockout mouse / oxidative stress / cardiomyopathy / endothelium / carbon monoxide / 抗酸化反応 / ノックアウトマウス / PAI-1 / 低酸素 / ミトコンドリア / 心筋症 / endothelin / endothelial injury / coronary vasospasm / Coronary microcirculation / 攣縮 / ヘンドセリン / エンドセリン / 内皮損傷 / 冠攣縮 / 冠微小循環 / vascular endothelial cell / oxidized LDL / oxygen radical / vascular injury / 急性心筋梗塞 / 虚血心筋 / 酸化LDL / 活性酸素 / 血管傷害 / statins / geranylgeranylation / lipid modification / nonselective cation current / Reactive oxygen species / Calcium / Endothelial cells / HMG-CoA還元酵素阻害薬 / リゾフォスファチジルコリン / パッチクランプ / 膜電流 / H_2O_2 / スタチン / ゲラニルゲラニル化 / 脂質修飾 / 非選択的カチオン電流 / 活性酸素種 / カルシウム / rabbit / mouse / Carbon Monoxide / ウサギ / マウス / 一酸化炭素 / ビリルビン / K-ATP channel / nitric oxide / metabolic vasodilation / exercise hyperemia / chronic heart failure / vasodilatory dysfunction / 血管拡張機序 / 骨格筋血管拡張 / 運動 / 骨格筋血管拡張機序 / ATP感受性Kチャンネル / 代謝性血管拡張 / 運動時血流 / 慢性心不全 / 血管拡張機能障害 / syndrome / Myelodysplastic / Granulocytes / Erythroblasts / Annexin V / GPI-anchored proteins / 赤血球前駆細胞 / 先天性CD59欠損症 / Inab phenotype / Apo 2.7 / TUNEL法 / 発作性夜間ヘモグロビン尿症(PNH) / 骨髄異形成症候群 / 赤芽球 / AnnexinV / 発作性夜間血色素尿症(PHN) / rats / angiotensin II / ACE inhibitor / coronary stenosis / remodeling / 血管内皮 / 好中球 / 冠狭窄 / リモデリング / 心筋虚血 / Sympathetic Nerve / Nitric Oxide / Coronary Circulation / Heart Failure / アデノシン / Nitric oxide / α受容体 / NO / 冠循環 / Phenotype / Flow cytometry / CD34^+ cells / Phosphatidylinositol glycan-class A (PIG-A) gene / Glycosylphosphatidylinositol (GPI)-anchored membrane proteins / Paroxysmal nocturnal hemoglobinuria (PNH) / 補体防御膜蛋白 / Tリンパ球 / 多核好中球 / PIG-A / phenotype / フローサイトメトリー / PIG-A遺伝子 / thrombopoietin / thrombocytopoiesis / megakaryocytopoiesis / cytokines / Interleukin 6 / Thrombopoietic factor / 巨核球 / 血小板造血 / Interleukinー6 / 血小板産産 / 血小板産生 / 巨核球造血 / サイトカイン / インタ-ロイキン6 / トロンボポエチン受容体 / 血管平滑筋細胞 / 再灌流傷害 / IL-6 / カルチトニン遺伝子関連ペプチド / 神経ペプチド / 冠血流量 / CGRP / カプサイシン / wpw syndrome / soura locarization / magnefocardography / 心磁図 / WPW syndrome / source localizadion / SQUID / magnetocardiogram Less

Analysis of defense mechanism of heme oxygenase against cardiovascular disorders and its clinical application
- Principal Investigator
  
  ISHIKAWA Kazunobu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel porcine model.
- Principal Investigator
  
  ISHIBASHI Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Signaling pathway and therapeutic strategy of endothelial dysfunction : role of small GTP-binding protein RhoA and beneficial effects of HMG-CoA reductase inhibitorPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yukio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Heme oxygenases, intrinsic defense system, as a novel therapeutic target for atherosclerotic disorders
- Principal Investigator
  
  ISHIKAWA Kazunobu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
ヘムオキシゲナーゼ1の心不全への関与の検討と臨床診断への応用Principal Investigator
- Principal Investigator
  
  丸山幸夫
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Role of Ca^<2+> signaling and reactive oxygen species in endothelial dysfunction induced by lysophosphatidylcholine
- Principal Investigator
  
  ISHIBASHI Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
ANALYSES OF ANTI-ATHEROGENIC PROPERTIES OF HEME OXYGENASE-1
- Principal Investigator
  
  ISHIKAWA Kazunobu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  FUKUSHMA MEDICAL UNIVERSITY
Therapeutic strategies for coronary stenosis-induced cardiac dysfunction and remodelingPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yukio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Mechanisms of peripheral vasodilatory dysfunction during exercise in chronic heart failure
- Principal Investigator
  
  MAEHARA Kazuhira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  FUKUSHIMA MEDICAL UNIVERSITY
Left ventricular remodeling in a rat model of hibernating myocardium
- Principal Investigator
  
  YAOITA Hiroyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Relationship between the expression of GPI-anchored proteins and apoptosis in PNH erythroid precursors.
- Principal Investigator
  
  SHICHISHIMA Tsutomu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Fukushima Medical University
サイトカインと接着分子の制御による心筋虚血・再灌流障害の軽減の新しい試み
- Principal Investigator
  
  矢尾板裕幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
トロンボポエチンの血管内皮細胞および血管平滑筋細胞に及ぼす作用
- Principal Investigator
  
  ISHIBASHI Toshiyuki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Fukushima Medical University
交感神経活動調節における平滑筋からの求心性インパルスの役割Principal Investigator
- Principal Investigator
  
  丸山幸夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Coronary Circulation in the Failing Heart
- Principal Investigator
  
  SAITO Tomiyoshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical College
心不全の病態において非アドレナリン性非コリン性神経系が果たす抗心不全作用の検討
- Principal Investigator
  
  YAOITA Hiroyuki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
Effects of nitric oxide on neointima formation after balloon arterial injury.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yukio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  FUKUSHIMA MEDICAL COLLEGE
Relationship between the expression of complement regulatory proteins and PIG-A gene abnormalities in CD34^+ cells of PNH.
- Principal Investigator
  
  SHICHISHIMA Tsutomu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Fukushima Medical College
正常及び病的心に於ける心・血管反応の自律神経調節Principal Investigator
- Principal Investigator
  
  丸山幸夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
非交感非副交感神経による心臓の神経性調節に関する実験的研究
- Principal Investigator
  
  渡辺直彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
超伝導素子を用いた心磁界計測技術の開発とその医学応用に関する研究
- Principal Investigator
  
  粟野直行
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukushima Medical University
The study on thrombopoietic activity of interleukin 6
- Principal Investigator
  
  KIMURA Hideo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Fukushima Medical College
運動負荷モデル犬による虚血心の病態解明について-特に,Anaerobic thresholdの意義の拡散機能障害を中心として-Principal Investigator
- Principal Investigator
  
  丸山幸夫
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tohoku University

All 2006 2005 2004

All Journal Article

[Journal Article] Hypoxemia and attenuated hypoxic ventilatory responses in mice lacking heme oxygenase-2 : evidence for a novel role of heme oxygenase-2 as an oxygen sensor.2006
- Author(s)
  Zhang Y, Furuyama K, Adachi T, Ishikawa K, Matsumoto H, Masuda T, Ogawa K, Takeda K, Yoshizawa M, Ogawa H, Maruyama Y, Hida W, Shibahara S.
- Journal Title
  
  Adv Exp Med Biol 580
  
  Pages: 161-166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590703
[Journal Article] Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction.2006
- Author(s)
  Matsumoto H, Ishikawa K, Itabe H, Maruyama Y.
- Journal Title
  
  Mol Cell Biochem (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590703
[Journal Article] Increased reactive oxygen species and anti-oxidative response in mitochondrial cardiomyopathy.2005
- Author(s)
  Ishikawa K, Kimura S, Kobayashi A, Sato T, Matsumoto H, UJ.iie Y, Nakazato K, Mitsugi M, Maruyama Y.
- Journal Title
  
  Circ J 69
  
  Pages: 617-620
- NAID
  110002696150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590703
[Journal Article] Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction.2005
- Author(s)
  Kawamura K, Ishikawa K, Wada Y, Kimura S, Matsumoto H, Kohro T, Itabe H, Kodama T, Maruyama Y.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590703
[Journal Article] Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.2005
- Author(s)
  Hiroshi Ohkawara, Toshiyuki Ishibashi, Takayuki Sakamoto, Koichi Sugimoto, Kenji Nagata, Keiko Yokoyama, Nobuo Sakamoto, Masashi Kamioka, Isao Matsuoka, Shigetomo Fukuhara, Naotoshi Sugimoto, Yoh Takuwa, Yukio Maruyama.
- Journal Title
  
  Journal of Biological Chemistry 280 (11)
  
  Pages: 10182-10188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590762
[Journal Article] Role of small GTP-binding proteins in endothelial dysfunction.2004
- Author(s)
  Toshiyuki Ishibashi, Yukio Maruyama.
- Journal Title
  
  Journal of Adaptation Medicine 8 (2)
  
  Pages: 23-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590762
[Journal Article] 血管内皮機能不全における低分子GTP結合蛋白質の役割2004
- Author(s)
  石橋敏幸, 丸山幸夫
- Journal Title
  
  適応医学 8(2)
  
  Pages: 23-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590762
[Journal Article] Repeated epicardial coronary artery endothelial injuries lead to a global spontaneous coronary artery spasm2004
- Author(s)
  Saitoh S, Ishibashi T, Maruyama Y, et al.
- Journal Title
  
  Coronary Artery Disease 15
  
  Pages: 137-145
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590762
[Journal Article] Repeated epicardial coronary artery endothelial injuries lead to a global spontaneous coronary artery spasm.2004
- Author(s)
  Shu-ichi Saitoh, Mitsuru Muto, Taku Osugi, Kazuhiko Aikawa, Ken Matsumoto, Futoshi Onogi, Kazuhira Maehara, Toshiyuki Ishibashi, Yukio Maruyama.
- Journal Title
  
  Coronary Artery Disease 15 (3)
  
  Pages: 137-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590762
[Journal Article] Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2.2004
- Author(s)
  Adachi T, Ishikawa K, Hida W, Matsumoto H, Masuda T, Date F, Ogawa K, Takeda K, Furuyama K, Zhang Y, Kitamuro T, Ogawa H, Maruyama Y, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 514-522
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590703

1. YAOITA Hiroyuki (50264544)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MAEHARA Kazuhira (90181817)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. ISHIBASHI Toshiyuki (00223024)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
4. ISHIKAWA Kazunobu (80222959)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
5. SAITO Tomiyoshi (30235056)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SAITO Shu-ichi (20274962)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SHICHISHIMA Tsutomu (10192105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KIMURA Hideo (00128547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TERASAWA Takashi (40083422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIKAMA Yayoi (40291562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 粟野直行 (00193095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 渡辺直彦 (20230980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 大谷弘 (80281236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAMOTO Tetsuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OGAWA Kazuei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SAITOH Yurie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 賀戸久

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 甲斐龍幸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 野地秀義

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MARUYAMA Yukio 丸山 幸夫

丸山 幸夫 マルヤマ ユキオ

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Signaling pathway and therapeutic strategy of endothelial dysfunction : role of small GTP-binding protein RhoA and beneficial effects of HMG-CoA reductase inhibitorPrincipal Investigator

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ヘムオキシゲナーゼ1の心不全への関与の検討と臨床診断への応用Principal Investigator

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Therapeutic strategies for coronary stenosis-induced cardiac dysfunction and remodelingPrincipal Investigator

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交感神経活動調節における平滑筋からの求心性インパルスの役割Principal Investigator

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MARUYAMA Yukio 丸山幸夫

丸山幸夫マルヤマユキオ