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KITADA Kouichi  北田 光一

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KITADA Mitsukazu  北田 光一

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Researcher Number 90110345
Other IDs
Affiliation (based on the past Project Information) *help 2006 – 2011: 千葉大学, 医学部附属病院, 教授
2008: 千葉大学, 医学部・附属病院, 教授
2002 – 2004: 千葉大学, 医学部附属病院, 教授
1997 – 1999: 千葉大学, 医学部, 教授
1998: 千葉大学, 医学部附属病院, 教授 … More
1993 – 1998: 千葉大学, 医学部・附属病院, 教授
1997: 千葉大学, 医学部・付属病院, 教授
1994: 千葉大学, 医学部附属病院, 教授
1992: 千葉大学, 医学部, 教授
1991: 千葉大学, 医学部・附属病院, 副薬剤部長
1988 – 1990: 北海道大学, 薬学部, 助教授 Less
Review Section/Research Field
Principal Investigator
応用薬理学・医療系薬学 / Medical pharmacy / Applied pharmacology / Biological pharmacy
Except Principal Investigator
応用薬理学・医療系薬学 / Medical pharmacy / 広領域 / Applied pharmacology / Conservative dentistry / Biological pharmacy / Biological pharmacy
Keywords
Principal Investigator
CYP3A7 / drug metabolism / 薬物代謝 / 胎児毒性 / 遺伝子多型 / CYP3A4 / CYP / steroid metabolism / ステロイド代謝 / 新生児 … More / 小児 / ブスルファン / 薬物代謝酵素 / C ratio / urinary 6β-OHF / endogenous steroids / neonate / C比 / 尿中6β-OHF / 内因性ステロイド / fetal toxicity / CYP3A / expression in COS-7 cells and TN-5 cells / CYP enzymes / ヒト胎児肝P450 / スラロイド代謝 / CYP3A酵素 / 心機能とステロイド / STS / DHEA-S / 心臓停止 / 薬物相互作用 / 医薬品副作用 / 母集団解析 / 薬物血中濃度モニタリング / 個別最適化 / グルタチオンS-転移酵素 / 薬物動態 / 造血幹細胞移植 / 血液がん / 血中濃度 / シクロフォスファミド / GST-π / GST-α / GST / 腎障害 / グルタチオン / グルタチオンS-トランスフェラ-ゼ / ヒト胎児肝 … More
Except Principal Investigator
alternative splicing / CYP2C9 / サル / 肝ミクロゾーム / チトクロームP-450 / 脳 / 遺伝子多型 / 薬物代謝 / チトクロムP450 / 相互作用 / 漢方薬 / P450 / 肝 / チトクロ-ムPー450 / Purification / Sex difference / Drug Metabolizing enzyme / Liver microsomes / Hamster / Cytochrome P-450 / ハムスター / チトクロ-ムP-450 / 精製 / 性差 / 薬物代謝酵素 / 肝ミクロゾ-ム / ハムスタ- / hepatic steatosis / Interindividual difference in ability of drug metabolism / 異種細胞発現系 / スプライシング / 遺伝的多型 / 脂肪肝 / 薬物代謝能の個体差 / Cytokine / Lipopolysaccharide / Gingival fibroblast / Proteoglycan / Gingival hyperplasia / Nifedipine / 高血圧 / 歯肉肥大 / ヘパラン硫酸プロテオグリカン / コンドロイチン硫酸プロテオグリカン / インターロイキン-4 / サイトカイン / リボポリサッカライド / 歯肉線維芽細胞 / プロテオグリカン / 歯肉増殖 / ニフェジピン / Microsomes / Drug metabolism / Cytochrome P450 / Liver / Brain / Monkey / チトクロームP450 / ミクロゾーム / シクロゾーム / イヌ / ヒト / 変異原物質活性化 / HLA ハプロタイプ / チエノピリじン / チエノピリジン / 遺伝子診断 / HLAハプロタイプ / 薬物誘発性肝障害 / オーダーメード医療 / 臨床研究 / 簡易遺伝子診断 / HLA allele / Idiosyncratic / 重篤肝障害 / チェノピリジン / オーダーメイド医療 / ヒト肝臓 / 発現系 / 医薬品代謝 / CYP1A1 / 微量発現 / マウス / 中性コレステロールエステラーゼ / スタチン / 中性コレステロールエスエラーゼ / コレステロール / SNP / 固体差 / CYP3A / PXR遺伝子 / ノトプテロール / ラット / ビリルビン尿症 / Pー450IA / 胎児肝 Less
  • Research Projects

    (21 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (13 People)
  •  Development of a system, which can pre-avoid anti-platelet agents-induced severe hepatic disfunction that is difficult to predict

    • Principal Investigator
      ARIYOSHI Noritaka
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  Study on the mechanism of lethal and serious drug-induced adverse event in fetusPrincipal Investigator

    • Principal Investigator
      KITADA Mitsukazu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Chiba University
  •  A role of the neutral cholesterol esterase in the cholesterol metabolism in the brain

    • Principal Investigator
      ITSUKO Ishii
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Chiba University
  •  超微量発現酵素が薬物の全身的代謝に果たす役割に関する常識を覆す研究

    • Principal Investigator
      有吉 範高
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  小児におけるがん化学療法の至適個別化に関する研究Principal Investigator

    • Principal Investigator
      北田 光一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  小児における遺伝子情報を考慮した抗癌剤の個別投与設計Principal Investigator

    • Principal Investigator
      北田 光一
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  Characterization of CYP2C9-splicing variant isolated from human liver

    • Principal Investigator
      ARIYOSHI Noritaka
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Chiba University
  •  CYP3A4の誘導的発現倍率を制御する遺伝要因の探索的臨床研究

    • Principal Investigator
      ARIYOSHI Noritaka
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  Study of medication design considering the drug metabolic activities in neonatal period.Principal Investigator

    • Principal Investigator
      KITADA Mitsukazu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  医薬品適正使用を指向した診断マーカーとしての薬物代謝酵素の有用性に関する研究Principal Investigator

    • Principal Investigator
      北田 光一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  Studies on the prediction of fetal toxicity caused by drugsPrincipal Investigator

    • Principal Investigator
      KITADA Mitsukazu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  Cytological and pharmacological studies on the pathogenesis of nifedipine-associated gingival hyperplasia

    • Principal Investigator
      NOGUCHI Kazuyuki, 魚島 マリコ
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  薬物間相互作用の予測に関する研究:漢方薬との相互作用を中心として

    • Principal Investigator
      大森 栄
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  最適な薬物投与設計を目指した薬物相互作用の予測に関する研究

    • Principal Investigator
      大森 栄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  Studies on prediction of fetal toxicity caused by drugs.Principal Investigator

    • Principal Investigator
      KITADA Mitsukazu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  Studies on the structure and function of cytochrome P450 in monkey brain

    • Principal Investigator
      OHMORI Shigeru
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Chiba University
  •  高ビリルビン尿症ラットの肝シトクロムP-450分子種変動機構の解明

    • Principal Investigator
      大森 栄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  胎児性肝チトクロ-ムPー450に関する薬理学的・毒性学的研究

    • Principal Investigator
      金久保 好男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Chiba University
  •  ヒト胎児肝に特異的に存在するグルタチオンS-トランスフェラ-ゼに関する研究Principal Investigator

    • Principal Investigator
      北田 光一
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  癌原・変異原物質を活性化するチトクロームP-450の発現と発癌リスクの予測

    • Principal Investigator
      鎌滝 哲也
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Regulation of Sex-Specific Forms of Cytochrome P-450 : Cytochrome P-450 in Liver Microsomes of Hamsters

    • Principal Investigator
      KAMATAKI Tetsuya
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      Hokkaido University

All 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese.2010

    • Author(s)
      Ariyoshi N, Iga Y, Hirata K, Sato Y, Miura G, Ishii I, Nagamori S, Kitada M.
    • Journal Title

      Drug Metab Pharmacokinet. 25

      Pages: 298-306

    • NAID

      10027583017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390045
  • [Journal Article] Six Novel Single Nucleotide Polymorphisms of the Steroid Sulfatase Geneina Japanese Population.2010

    • Author(s)
      Matsumoto J, Ariyoshi N, Ishii I, Kitada M.
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 25 Pages: 403-407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390157
  • [Journal Article] Enhanced susceptibility of HLA-mediated ticlo-pidine-induced idiosyncratic hepato-toxicity by CYP2B6 polymorphism in Japanese2010

    • Author(s)
      Ariyoshi N, Iga Y, Hirata K, Sato Y, Miura G, Ishii I, Nagamori S, Kitada M.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25(3) Pages: 298-306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390045
  • [Journal Article] Six Novel Single Nucleotide Polymorphisms of the Steroid Sulfatase Gene in a Japanese Population.2010

    • Author(s)
      Matsumoto J, Ariyoshi N, Ishii I, Kitada M
    • Journal Title

      Drug Metab Pharmacokinet. 25(4)

      Pages: 403-407

    • NAID

      10027583501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390157
  • [Journal Article] Growth inhibition and differentiation of cultured smooth muscle cells depend on cellular crossbridges across the tubular lumen of type I collagen matrix honeycombs2009

    • Author(s)
      Suzuki T, Ishii I, Kotani A, Masuda M, Hirata K, Ueda M, Ogata T, Sakai T, Ariyoshi N, Kitada M
    • Journal Title

      Microvasc Res 77(2)

      Pages: 143-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590056
  • [Journal Article] Growth inhibition and differentiation of cultured smooth muscle cells depend on sellular crossbridges across the tubular lumen of type I collagen matrix honeycombs.2009

    • Author(s)
      Suzuki T, Ishii I, Kotani A, Masuda M, Hirata K, Ueda M, Ogata T, Sakai T, Ariyoshi N, Kitada M
    • Journal Title

      Microvasc Res. 77(2)

      Pages: 143-149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590056
  • [Journal Article] Effect of pitavastatin on macrophage cholesterol metabolism2008

    • Author(s)
      Akisato Y, Ishii I, Kitahara M, Tamaki T, Saito Y, Kitada M
    • Journal Title

      Yakugaku Zasshi 128(3)

      Pages: 357-63

    • NAID

      110006646588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590056
  • [Journal Article] Effect of pitavastatin on macrophage cholesterol metabolism.2008

    • Author(s)
      Akisato Y, ishii I, Kitahara M, Tamaki T, Saito Y, Kitada M
    • Journal Title

      Yakugaku Zasshi 128(3)

      Pages: 357-363

    • NAID

      110006646588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590056
  • [Presentation] タウリンクロラミンのコレステロール蓄積抑制作用2009

    • Author(s)
      宮崎宏史、石井伊都子、有吉範高、北田光一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-19590056
  • 1.  ITSUKO Ishii (00202929)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 9 results
  • 2.  ARIYOSHI Noritaka (00243957)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 7 results
  • 3.  OHMORI Shigeru (70169069)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  OHI Hiroaki (60194065)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  KOMORI Masayuki (40183347)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KAMATAKI Tetsuya (00009177)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  NOGUCHI Kazuyuki (90218298)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  仲佐 啓詳 (60260478)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  CHIBA Kan (40159033)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  YANAGISHITA Masaki (70132793)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  金久保 好男 (30004873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  力久 忠昭 (70012622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  魚島 マリコ (50228425)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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