HORIE Toshiharu 堀江利治

Researcher Number	90120154
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2017: 帝京平成大学, 薬学部, 教授 2011 – 2012: 千葉大学, 薬学研究科(研究院), 教授 2009 – 2012: Chiba University, 大学院・薬学研究院, 教授 2007: Chiba University, Graduate school of pharmaceutical sciences, Professor 2006: 千葉大学, 大学院薬学研究院, 教授 … More 2001 – 2005: 千葉大学, 大学院・薬学研究院, 教授 2004: 千葉大学, 薬学研究科(研究院), 教授 1997 – 1999: 千葉大学, 薬学部, 教授 1993 – 1995: Faculty of Pharmaceutical Sciences, Chiba Univ. Professor, 薬学部, 教授 1992 – 1993: 東京薬科大学, 薬学部, 助教授 1988 – 1991: 東京薬科大学, 薬学部, 講師 1990: 東京薬科大学, 薬学部 1986: Tokyo College of Pharmacy, 薬学部, 講師 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Medical pharmacy / Physical pharmacy / Biological pharmacy Except Principal Investigator 応用薬理学・医療系薬学 / Biological pharmacy / Physical pharmacy / Medical pharmacy
Keywords	Principal Investigator グルタチオン / MRP2 / glutathione / oxidative stress / 化学発光 / 肝細胞 / 脂質過酸化 / 酸化的ストレス / chemiluminescence / hepatocyte … More / hepatotoxicity / 肝毒性 / 肝障害 / 薬学 / 酸化ストレス / lipid peroxidation / アセトアミノフェン / ミトコンドリア / 国際情報交換 / ヘム生合成 / ヘムオキシゲナーゼ / ヘム / 薬剤性肝障害 / C型肝炎 / Acetaminophen / Fluorescent Substance / Liver Microsome / Hepatocyte / Glutathione / Lipid Peroxidation / Hepatotoxicity / Drug Toxicity / 蛍光寿命 / 肝ミクロゾーム / 蛍光物質 / 肝ミクロゾ-ム / 四塩化炭素 / 蛋白重合体 / 蛍光性物質 / 肝ミクロソ-ム / 薬物毒性 / Protein / Drug reactivity / Signal transduction / Biophysical / 蛋自質 / 蛋白質 / 薬剤反応性 / シグナル伝達 / 生物物理 / nitric oxide / protein kinase C / transporter / biliary excretion / cholestasis / 一酸化窒素 / Protein kinase C / トランスポーター / 胆汁排泄 / 胆汁うっ滞 / reactive oxygens / 4-hydroxynonenal / エタクリン酸 / 活性酸素 / 4-ヒドロキシノネナール / cytochrome P450 / reactive metabolite / ジヒドララジン / サリチル酸 / ATP / ジクロフェナック / 非ステロイド系抗炎症薬 / シトクロムP450 / 活性代謝物 / naproxen / acetaminophen / ナプロキセン / cell culture / crypt cell / L1210 murine leukemia cell / intestinal absorption / intestinal damage / D-glucose / methotrexate / vitamin A / Dーグルコ-ス / メトトレキサ-ト / L-ロイシン / 小腸培養細胞IEC-6 / 抗癌作用 / 小腸粘膜 / マウス肉腫細胞ザルコーマ180 / 細胞培養 / 小腸クリプト細胞 / マウス白血病細胞L1210 / 腸管吸収 / 消化器障害 / D-グルコース / メトトレキサート / ビタミンA / 特異体質性薬物毒性 / 薬物感受性 / 糖尿病 / 酸素消費 / MPT / 医薬品毒性 / 毒性予測 / 医薬品 / ミトコンドリア毒性 / 生活習慣病 / 薬剤反応生 / 代謝学 / 薬物動態 / 臨床 / 放射線 / プロテオーム … More Except Principal Investigator 吸収促進剤 / 細胞内ルート / 細胞間ルート / transcellular route / paracellular route / absorption promoter / Drug-induced liver injury / アセトアミノフェン / 薬剤性肝障害 / インピ-ダンス解析 / 結腸 / 空腸 / パイエル板 / Caco-2細胞 / Simultaneous Luminal and Vascular Perfusion / Blood Flow Dependence / Membrane Perturbation / Impedance Analysis / Equivalent Pore Radius / Absorptive Site Difference / Transcellular Route / Intercellular Route / 膜透過律速 / 血流律速 / 膜perturbation / Eguivalent Pore半径 / 血管壁透過性 / 吸収部位血流 / Voltage Clamp法 / 腸管血菅同時潅流法 / アクチン-ミオシンリング / Tight junction / 腸管血管同時潅流法 / 血流依存性 / 膜Perturbation / Equivalent ポア-半径 / 吸収部位差 / 細胞内ル-ト / 細胞間ル-ト / fluorescence polarization / pore radius / water absorption / 膜流動性 / 蛍光偏光解消法 / 細孔サイズ / 血流 / 水の吸収 / binding protein / membrane permeability / Albumin / hepatocyte / 骨格筋 / 結合タンパク / 膜透過性 / アルブミン / 肝細胞 / Idiosyncratic hepatotoxicity / Cyclosporin A / Thiazolidinediones / Troglitazone / Antidiabetic agent / Mitochondrial permeability transition / Mitochondria / シトクロムc / グルタチオン / 酸化ストレス / 特異体質性肝障害 / シクロスポリンA / チアゾリジンジオン / トログリタゾン / 糖尿病治療薬 / ミトコンドリア透過性遷移 / ミトコンドリア / Toll-like receptor 4 / Endotoxin / Indomethacin / Heat shock proteins / Interleukin-6 / Acetaminophen / Cytokines / シトクロムP450 / ジクロフェナック / インターロイキン-10 / TNF-α / Toll様受容体4 / エンドトキシン / インドメタシン / 熱ショックタンパク質 / インターロイキン-6 / サイトカイン / Enkephalin / VitaminA / Glucose transporter / Peptide / Intracellular calcium / Tight iunction / Caco-2 / Absorption enhancement / 糖付加 / レクチン / 吸収改善 / エンケファリン / ビタミンA / グルコース輸送担体 / ペプチド / 細胞内カルシウム / タイトジャンクション / 吸収促進 / Adsorptive Endocytosis / Peyer's Patches / Caprate / Caco-2 Cells / Actomyosin / Polypeptide / Paracellular Pathway / Absorption Enhancer / 高分子量物質 / 細胞内経路 / Caco‐2細胞 / M細胞 / 細胞間隙 / 高分子ペプチド / カルモジュリン / 吸着性エンドサイトーシス / カプリン酸 / アクトミオシン / ポリペプチド / 細胞間隙経路 Less

C型肝炎時の肝細胞内ヘム代謝に着目した薬剤性肝障害メカニズムの解明Principal Investigator
- Principal Investigator
  
  堀江利治
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo Heisei University
Analysis of idiosyncratic drug toxicity using mitochondria isolated from an animal model of metabolic syndromePrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo Heisei University
Quantitative analysis of drugs induced BSEP inhibition and cholestatic hepatotoxicityPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Molecular analysis of localization of biliary transporters in chronic hepatitisPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Intrahepatic imaging and molecular analysis of MRP2 localization regulated by the intracellular redox statusPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
MRP2 mediated defense against oxidative stress in liverPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Role of Mitochondria as Signal Sensors in Drug-Induced Liver Injury
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  CHIBA INSTITUTE OF SCIENCE
  Chiba University
Involvement of cytokines in drug-induced liver injury
- Principal Investigator
  
  MASUBUCHI Yasuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  CHIBA UNIVERSITY
Evaluation of drug-induced hepatotoxicity by chemiluminescence and the role of MRP2 in the hepatotoxicityPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
The drug-induced hepatotoxicityPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Pharmacokinetics and Hepatotoxicity due to the oxidative stressPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Improvemrnt of Drug Absorption in Gastro intestinal Tract
- Principal Investigator
  
  AWAZU Shoji
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
A Study on Protective Effect of Vitamin A against Antitumour Drug-Induced Damage to Small IntestinePrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo College of Pharmacy
Membrane Permeability and Its Improvement in Intestinal Absorption of Macromolecular Drugs
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
  Tokyo University of Pharmacy and Life Science
Quantitative Evaluation and Prediction of Drug-Toxicity Due to Lipid PeroxidationPrincipal Investigator
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Physiological and Anatomical Factors Controlling Intestinal Drug Absorption Mechanism
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanism for the Enhancement of Intestinal Paracellular and Transcellular Permeability by Absorption Promoters
- Principal Investigator
  
  MASAHIRO Hayashi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo College of Pharmacy
Factors in Cell Membrane Transport and Tissue Distribution of Drugs
- Principal Investigator
  
  AWAZU Shoji
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo College of Pharmacy

[Book] (分担執筆)「新有機医薬品合成化学」、田口武夫、小林進、東山公男編薬物代謝2012
- Author(s)
  堀江利治
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-21249003
[Book] 「最新薬剤学第10版」、林正弘、尾関哲也、乾賢一編2012
- Author(s)
  堀江利治
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-23659073
[Book] 「新有機医薬品合成化学」、田口武夫、小林進、東山公男編2012
- Author(s)
  堀江利治
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-23659073
[Book] Extrapolationod In vitro Metabolic and P-Glycoprotein-mediated Transport data to In vivo by Modeling and Simulations, in "Enzyme- and Transporter-Based drug-drug interactions"2010
- Author(s)
  Kato M, Shitara Y, Kitajima M, Tachibana T, Igarashi M, Horie T, Sugiyama Y
- Publisher
  Springer, NY, USA
- Data Source
  KAKENHI-PROJECT-23659073
[Book] Web-Based Database as a Tool to examine drug-drug interactions involving transporters in Enzyme- and Transporter-Based drug-drug interactions"2010
- Author(s)
  Maeda K, Shitara Y, Horie T, Sugiyama Y.
- Publisher
  Springer, NY, USA
- Data Source
  KAKENHI-PROJECT-23659073
[Book] Extrapolationod In vitro Metabolic and P-Glycoprotein-mediated Transport data to In vivo by Modeling and Simulations, in "Enzyme- and Transporter-Based drug-drug interactions"2010
- Author(s)
  Kato M, Shitara Y, Kitajima M, Tachibana T, Igarashi M, Horie T, Sugiyama Y.
- Publisher
  Springer, NY, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Book] Drug-drug interactions in pharmaceutical development2007
- Author(s)
  Shitara Y, Horie T, Sugiyama Y
- Total Pages
  244
- Publisher
  John Wiley and Sons
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Establishment of a drug-induced, bile acid-dependent hepatotoxicity model using HepaRG cells2016
- Author(s)
  Susukida T, Sekine S, Nozaki M, Tokizono M, Oizumi K, Horie T, Ito K
- Journal Title
  
  J Pharm Sci
  
  Volume: 43 Issue: 4 Pages: 1550-1560
- DOI
  10.1016/j.xphs.2016.01.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084, KAKENHI-PROJECT-24390037, KAKENHI-PROJECT-16K08377
[Journal Article] Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences.2016
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Eur J Drug Metab Pharmacokinet.
  
  Volume: 41 Issue: 2 Pages: 93-108
- DOI
  10.1007/s13318-015-0296-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
[Journal Article] Metabolic activation of hepatotoxic drug (benzbromarone) induced mitochondrial membrane permeability transition.2015
- Author(s)
  Shirakawa M, Sekine S, Tanaka A, Horie T, Ito K.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 288 Issue: 1 Pages: 12-18
- DOI
  10.1016/j.taap.2015.06.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084, KAKENHI-PROJECT-24390037
[Journal Article] Mitochondrial iron accumulation exacerbates hepatic toxicity caused by hepatitis C virus core protein2015
- Author(s)
  Sekine S, Ito K, Watanabe H, Nakano T, Moriya K, Shintani Y, Fujie H, Tsutsumi T, Miyoshi H, Fujinaga H, Shinzawa S, Koike K, Horie T.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 282 Issue: 3 Pages: 237-243
- DOI
  10.1016/j.taap.2014.12.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
[Journal Article] Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes.2015
- Author(s)
  Susukida T, Sekine S, Ogimura E, Aoki S, Oizumi K, Horie T, Ito K.
- Journal Title
  
  Toxicol In Vitro
  
  Volume: 29 Issue: 7 Pages: 1454-1463
- DOI
  10.1016/j.tiv.2015.06.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
[Journal Article] Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect oncomplex I respiration in mitochondria.2013
- Author(s)
  Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T.
- Journal Title
  
  Toxicol Sci.
  
  Volume: 132(1) Pages: 32-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibitory effects of saquinavir and ritonavir on OATP1B1-mediated uptake2013
- Author(s)
  Shitara Y, Takeuchi K, Horie T.
- Journal Title
  
  J Pharm Sci
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibitory effects of saquinavir and ritonavir on OATP1B1-mediated uptake.2013
- Author(s)
  Shitara Y, Takeuchi K, Horie T.
- Journal Title
  
  J Pharm Sci.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Clinical significanceof organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.2013
- Author(s)
  Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 34(1) Pages: 45-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The Mechanism of the Down-Regulation of Hepatic Transporters in Rats with Indomethacin-Induced Intestinal Injury2013
- Author(s)
  Fujiyama N, Shitara Y, Horie T.
- Journal Title
  
  Dig Dis Sci
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina2013
- Author(s)
  Oga EF, Sekine S, Horie T.
- Journal Title
  
  Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics: Assessing the significance on rat intestinalP-glycoprotein efflux. Drug Metab Pharmacokinet
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption2013
- Author(s)
  Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y.
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 34(1) Pages: 45-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics: Assessing the significance on rat intestinal P-glycoprotein efflux.2013
- Author(s)
  Oga EF, Sekine S, Horie T.
- Journal Title
  
  Drug Metab Pharmacokinet.
- NAID
  50008758069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Ex Vivo and In Vivo Investigations of the Effects of Extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on Digoxin Transport and Pharmacokinetics: Assessing the Significance on Rat Intestinal P-glycoprotein Efflux2013
- Author(s)
 Oga EF, Sekine S, Horie T.
- Journal Title
 
 Drug Metabolism and Pharmacokinetics
 
 Volume: 28 Issue: 4 Pages: 314-320
- DOI
 10.2133/dmpk.DMPK-12-RG-117
- NAID
 130004463319
- ISSN
 1347-4367, 1880-0920
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] The Mechanism of the Down-Regulation of Hepatic Transporters in Rats with Indomethacin-Induced Intestinal Injury.2013
- Author(s)
  Fujiyama N, Shitara Y, Horie T.
- Journal Title
  
  DigDis Sci.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect oncomplex I respiration in mitochondria2013
- Author(s)
  Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T.
- Journal Title
  
  Toxicol Sci
  
  Volume: 132(1) Pages: 32-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 in rat liver.2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1822(6) Pages: 980-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol Pharm
  
  Volume: 9(11) Pages: 3023-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting Inhibitory Effects of Cyclosporin A, but Not Tacrolimus, on OATP1B1- and OATP1B3-mediated Uptake2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 27 Issue: 4 Pages: 368-378
- DOI
  10.2133/dmpk.DMPK-11-RG-096
- NAID
  130004463264
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats2012
- Author(s)
  Suzuki K, Shitara Y, Fukuda K, Horie T.
- Journal Title
  
  J Pharm Sci
  
  Volume: 101(7) Pages: 2606-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- andOATP1B3-mediated uptake.2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug MetabPharmacokinet.
  
  Volume: 27(4) Pages: 368-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistanceassociated protein 2 in rat liver.2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1822 Issue: 6 Pages: 980-987
- DOI
  10.1016/j.bbadis.2012.01.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-22790146, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements.2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol Pharm.
  
  Volume: 9(11) Pages: 3023-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- andOATP1B3-mediated uptake2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27(4) Pages: 368-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats.2012
- Author(s)
  Suzuki K, Shitara Y, Fukuda K, Horie T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101 Issue: 7 Pages: 2606-2615
- DOI
  10.1002/jps.23174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 inrat liver2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1822(6) Pages: 980-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake2012
- Author(s)
  Shitara Y, Takeuchi K, Nagamatsu Y, Wada S, Sugiyama Y, Horie T
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: (In press)
- NAID
  130004463264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 144 Issue: 3 Pages: 612-617
- DOI
  10.1016/j.jep.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporinA in rats.2012
- Author(s)
  Suzuki K, Shitara Y, Fukuda K, Horie T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101(7) Pages: 2606-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Potential P-glycoprotein-mediateddrug-drug interactions of antimalarial agents in Caco-2 cells.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 87(1) Pages: 64-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements.2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol. Pharm.
  
  Volume: 9 Issue: 11 Pages: 3023-3033
- DOI
  10.1021/mp300083e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172, KAKENHI-PROJECT-24590045
[Journal Article] Potential P-glycoprotein-mediateddrug-drug interactions of antimalarial agents in Caco-2 cells2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg
  
  Volume: 87(1) Pages: 64-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistanceassociated protein 2 in rat liver2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Potential P-glycoprotein-mediated drug-drug interactions of antimalarial agents in Caco-2 cells.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 87 Issue: 1 Pages: 64-69
- DOI
  10.4269/ajtmh.2012.11-0817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes2011
- Author(s)
  Ogimura E, Sekine S, Horie T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 81(1) Pages: 178-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1812(11) Pages: 1427-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status.2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  BiochemBiophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2(Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Yano K, Hashimoto N, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81 Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women.2011
- Author(s)
  Tanii H, Shitara Y, Horie T.
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 67(10) Pages: 1017-1025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women.2011
- Author(s)
  Tanii H, Shitara Y, Horie T.
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 67(10) Pages: 1017-25
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] LPS-induced dissociation of multidrugresistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 416(3-4) Pages: 313-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women2011
- Author(s)
  Tanii H, Shitara Y, Horie T.
- Journal Title
  
  Eur J Clin Pharmacol
  
  Volume: 67(10) Pages: 1017-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women2011
- Author(s)
  Tanii H, Shitara Y, Horie T
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 67(10) Pages: 1017-1025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats2011
- Author(s)
  Saeki J, Sekine S, Horie T
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status.2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.2010
- Author(s)
  Maeda, T., Miyazono, Y., Ito.K., Hamada, K., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. 65
  
  Pages: 1117-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada, K., Shitara, Y., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Salicylic acid-induced hepatotoxicity triggered by oxidative stress.2010
- Author(s)
  Doi, H., Horie, T.
- Journal Title
  
  Chem Biol Interact. 183
  
  Pages: 363-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition.2010
- Author(s)
  Okuda T, Norioka M, Shitara Y, Horie T.
- Journal Title
  
  Toxicol ApplPharmacol.
  
  Volume: 248(3) Pages: 242-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.2010
- Author(s)
  Maeda T, Miyazono Y, Ito K, Hamada K, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 65(6) Pages: 1117-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition2010
- Author(s)
  Okuda T, Norioka M, Shitara Y, Horie T.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 248 Pages: 242-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat.2010
- Author(s)
  Yano K, Sekine S, Nemoto K, Fuwa T, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 80 Pages: 533-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Involevement of advanced glycation end-products, pentosidine and N(epsilon)-(carboxymethyl)lysine, in doxorubicin-induced cardiomyopathy in rats.2010
- Author(s)
  Moriyama, T., Kemi, M., Okumura, C., Yoshihira, K., Horie, T
- Journal Title
  
  Toxicology 31
  
  Pages: 89-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada K, Shitara Y, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 66(6) Pages: 1031-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in therat.2010
- Author(s)
  Yano K, Sekine S, Nemoto K, Fuwa T, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 80(4) Pages: 533-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Salicylic acid-induced hepatotoxicity triggered by oxidative stress.2010
- Author(s)
  Doi H, Horie T.
- Journal Title
  
  Chem Biol Interact.
  
  Volume: 183(3) Pages: 363-8
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Involvement of advanced glycation end-products, pentosidine andN(epsilon)-(carboxymethyl)lysine, in doxorubicin-induced cardiomyopathy in rats.2010
- Author(s)
  Moriyama T, Kemi M, Okumura C, Yoshihara K, Horie T.
- Journal Title
  
  Toxicology.
  
  Volume: 268(1-2) Pages: 89-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Oxidative stress is a triggering factor for LPS-induced Mrp2 internali zation in the cryopreserved rat and human liver slices.2010
- Author(s)
  Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 399 Pages: 279-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.2010
- Author(s)
  Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T.
- Journal Title
  
  Biochem Biophys ResCommun.
  
  Volume: 399(2) Pages: 279-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine.2009
- Author(s)
  Nakano, T., Sekine, S., Ito, K., Horie, T.
- Journal Title
  
  Drug.Metab.Dispos. 37
  
  Pages: 1521-1527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Protective effect of aged garlic extract (AGE) on the apotosis of intestinal epithelial cells caused by methotrexate.2009
- Author(s)
  Li, T., Ito, K., Sumi, S., Fuwa, T., Horie, T.
- Journal Title
  
  Cancer Chemother Pharmacol. 63
  
  Pages: 873-880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibition of the transporter-mediated hepatic up atake of sulfobromophthalein by cyclosporine A in rats.2009
- Author(s)
  Shitara, Y., Nagamatsu, Y., Wada, S., Sugiyama, Y., Horie, T.
- Journal Title
  
  Drug.Metab.Dispos. 37
  
  Pages: 1172-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats.2009
- Author(s)
  Shitara Y, Nagamatsu Y, Wada S, Sugiyama Y, Horie T.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 37(6) Pages: 1172-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine.2009
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 37(7) Pages: 1521-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.2008
- Author(s)
  Masubuchi Y, Enoki K, Horie T.
- Journal Title
  
  Drug Metab Dispos. 36(3)
  
  Pages: 597-603
- NAID
  130005024164
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis2008
- Author(s)
  Masubuchi Y, Enoki K, Horie T.
- Journal Title
  
  Drug Metab Dispos. 36 (3)
  
  Pages: 597-603
- NAID
  130005024164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic cytochrome P450 enzymes in ratswith trinitrobenzene sulfonic acid-induced colitis2008
- Author(s)
  Masubuchi Y, Enoki K, Horie T.
- Journal Title
  
  Drug Metab Dispos 36(3)
  
  Pages: 597-603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T.
- Journal Title
  
  Biol Pharm Bull. 30(3)
  
  Pages: 556-61
- NAID
  110006239203
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T.
- Journal Title
  
  Biol Pharm Bull. 30 (3)
  
  Pages: 556-561
- NAID
  110006239203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic transporters for BSP in rats withindomethacin-induced intestinal injury2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T.
- Journal Title
  
  Biol Pharm Bull 30(3)
  
  Pages: 556-561
- NAID
  110006239203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.2007
- Author(s)
  Masubuchi Y, Horie T.
- Journal Title
  
  Crit Rev Toxicol. 37(5)
  
  Pages: 389-412
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes.2007
- Author(s)
  Yamashiro JI, Shiraishi S, Fuwa T, Horie T.
- Journal Title
  
  Cell Biol Toxicol. (Epub ahead of print)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs2007
- Author(s)
  Masubuchi Y, Horie T.
- Journal Title
  
  Crit Rev Toxicol 37(5)
  
  Pages: 389-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs2007
- Author(s)
  Masubuchi Y, Horie T.
- Journal Title
  
  Crit Rev Toxicol. 37 (5)
  
  Pages: 389-412
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes2007
- Author(s)
  Yamashiro JI, Shiraishi S, Fuwa T, Horie T.
- Journal Title
  
  Cell Biol Toxicol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Drug-drug interactions in pharmaceutical development2007
- Author(s)
  Shitara Y, Horie T, Sugiyama Y.
- Journal Title
  
  John Wiley and Sons 244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes2007
- Author(s)
  Yamashiro JI, Shiraishi S, Fuwa T, Horie T.
- Journal Title
  
  Cell Biol Toxicol [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.2007
- Author(s)
  Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T
- Journal Title
  
  Biol Pharm Bull. 30(3)
  
  Pages: 556-61
- NAID
  110006239203
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Oxidative stress and Mrp2 internalization.2006
- Author(s)
  Sekine S, Ito K, Horie T.
- Journal Title
  
  Free Radic Biol Med. 40(12)
  
  Pages: 2166-74
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Functional analysis of mouse and monkey multidrug resistance-associated protein 2(Mrp2).2006
- Author(s)
  Ninomiya M, Ito K, Hiramatsu R, Horie T
- Journal Title
  
  Drug Metab Dispos. 34(12)
  
  Pages: 2056-63
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Naproxen-induced oxidative stress in the isolated perfused rat liver2006
- Author(s)
  Yokoyama H, Horie T, Awazu S
- Journal Title
  
  Chem.Biol.Interact. 160(2)
  
  Pages: 150-158
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport2006
- Author(s)
  Ito K, Suzuki H, Horie T, Sugiyama Y
- Journal Title
  
  Pharm.Res. 22(10)
  
  Pages: 1559-1577
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Naproxen-induced oxidative stress in the isolated per fused rat liver2006
- Author(s)
  Yokoyama H, Horie T, Awazu S
- Journal Title
  
  Chem.Biol.Interact. 160-2
  
  Pages: 150-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Naproxen-induced oxidative stress in the isolated perfused rat liver2006
- Author(s)
  Yokoyama H, Horie T, Awazu S
- Journal Title
  
  Chem. Biol. Interact. 160 (2)
  
  Pages: 150-158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice2005
- Author(s)
  Masubuchi Y, Suda C, Horie T
- Journal Title
  
  J.Hepatol. 42(1)
  
  Pages: 110-116
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Functional analysis of dog multidrug resistance associated protein 2(Mrp2) in comparison with rat Mrp22005
- Author(s)
  Ninomiya M, Ito K, Horie T
- Journal Title
  
  Drug Metab.Dispos. 33(2)
  
  Pages: 225-232
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Mrp2/Abcc2 transport activity is stimulated by Protein kinase C alpha in a bacula virus co-expression system2005
- Author(s)
  Ito K, Wakabayashi T, Horie T
- Journal Title
  
  Life Sci. 77 (5)
  
  Pages: 539-550
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Mrp2/Abcc2 transport activity is stimulated by Protein kinase C alpha in a bacula virus co-expression system2005
- Author(s)
  Ito K, Wakabayashi T, Horie T
- Journal Title
  
  Life Sci. 77(5)
  
  Pages: 539-550
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Functional analysis of dog raultidrug resistance associated protein 2 (Mrp2) in comparison with rat Mrp22005
- Author(s)
  Ninomiya M, Ito K, Horie T
- Journal Title
  
  Drug Metab.Dispos. 33(2)
  
  Pages: 225-232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport2005
- Author(s)
  Ito K, Suzuki H, Horie T, Sugiyama Y
- Journal Title
  
  Pharm. Res. 22 (10)
  
  Pages: 1559-1577
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Functional analysis of dog multidrug resistance associated 2(Mrp2) in Comparison with rat Mrp22005
- Author(s)
  Ninomiya M, Ito K, Horie T
- Journal Title
  
  Drug Metab. Dispos. 33 (2)
  
  Pages: 225-232
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in rat model of dextran sulfate sodium-induced experimental colitis2004
- Author(s)
  Masubuchi Y, Horie T
- Journal Title
  
  Drug Metab.Dispos. 32(4)
  
  Pages: 437-441
- Data Source
  KAKENHI-PROJECT-16390014
[Journal Article] Ethacrynic acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver2004
- Author(s)
  Ji B, Ito K, Sekine S, Tajima A, Horie T
- Journal Title
  
  Free Radic.Biol.Med. 37(11)
  
  Pages: 1718-1729
- Data Source
  KAKENHI-PROJECT-16390014
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-21249003
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23659073
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  関根秀一、堀江利治
- Industrial Property Rights Type
  特許
- Filing Date
  2011-05-08
- Acquisition Date
  2012-07-03
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎モデル細胞におけるエタノールのヘム生合成経路への影響の検討2018
- Author(s)
  中埜貴文，磯崎泰也，三浦美香，濱田和真，森屋恭爾，小池和彦，堀江利治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08377
[Presentation] 薬剤性肝障害感受性決定因子としての2型糖尿病肝ミトコンドリア薬物毒性の解析2018
- Author(s)
  濱田和真,中埜貴文, 堀江利治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08377
[Presentation] 肥満・糖尿病時における薬物性肝障害リスク上昇メカニズムの解析2017
- Author(s)
  濱田和真, 武石麗菜, 瀧川めぐみ, 上野聡彦, 中埜貴文, 堀江利治
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学（宮城県・仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08377
[Presentation] The effect of HCV core protein on heme synthesis pathway in human hepatocellular carcinoma cells2016
- Author(s)
  Takafumi Nakano, Kazuma Hamada, Kyoji Moriya, Kazuhiko Koike and Toshiharu Horie
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール／松本市総合体育館（長野県・松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08377
[Presentation] HCVコア蛋白質が惹起する細胞内ポルフィリン代謝異常に関する検討2016
- Author(s)
  中埜貴文、濱田和真、森屋恭爾、小池和彦、堀江利治
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26670084
[Presentation] 2型糖尿病時の肝臓ミトコンドリアにおける薬物障害性の解析2016
- Author(s)
  濱田和真、桜田啓広、齋藤希衣、中埜貴文、堀江利治
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26670084
[Presentation] C型肝炎ウイルスが惹起する細胞内ポルフィリン代謝異常についての検討2015
- Author(s)
  中埜貴文, 濱田和真, 森屋恭爾, 小池和彦, 堀江利治
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26670084
[Presentation] Interspecies differences in glibenclamide induced bile acid dependent hepatotoxicity between rat and human sandwich cultured hepatocytes2012
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Ken-ichi Kaneko, Takafumi Nakano, Tomoharu Osada, Hiroshi Iwata, Toshiharu Horie,
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich-cultured hepatocytes enable a predictive evaluation of BSEP/Bsep dysfunction-mediated2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  drug-inducedhepatotoxicity SOT
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Interspecies differences in glibenclamide induced bile acid dependent hepatotoxicity between rat and human sandwich cultured hepatocytes2012
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Ken-ichi Kaneko, Takafumi Nakano, Tomoharu Osada, Hiroshi Iwata, Toshiharu Horie,
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根　秀一、薄田　健史、荻村　栄一郎、堀江利治
- Organizer
  日本薬剤学会　第２７年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation]2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  C型肝炎の病態悪化に対するミトコンドリア鉄蓄積と鉄取り込み機構の関与肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス誘発性胆汁っ滞時における排泄輸送体の局在制御機構の解明2012
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes2012
- Author(s)
  Sekine S, Ogimura E, Horie T
- Organizer
  51th Society of Toxicology meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸における薬物トランスポーターMRP2/ABCC2、MDR1/ABCB1 の細胞膜局在制御機構の解明2012
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根秀一、薄田健史、荻村栄一郎、堀江利治
- Organizer
  第27年会日本薬剤学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 小腸における薬物トランスポーターMRP2/ABCC2、MDR1/ABCB1 の細胞膜局在制御機構の解明2012
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Inhibitory effects of high-dose tea cathechins on multidrug resistance associated protein 2 (MRP2) function,2012
- Author(s)
  Emi Okubo, Kenichi Wakabayashi, Toshio Kasamatsu, Naohiro Nishiyama, Shuichi Sekine, Toshiharu Horie
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Evaluation of bile acid dependent drug induced liver injury in sandwich cultured hapatocytes2012
- Author(s)
  Sekine, S, Ogimura E, Horie T.
- Organizer
  The 19th International Synposium on Microsomes and Drug Oxidations
- Place of Presentation
  Noordwijik aan Zee、the Netherlands
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Evaluation of bile acid dependent drug induced liver injury in sandwich cultured hapatocytes2012
- Author(s)
  Sekine, S, Ogimura E, Horie T.
- Organizer
  The 19th International Synposium on Microsomes and Drug Oxidations
- Place of Presentation
  Noordwijik aan Zee, the Netherlands
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎の病態悪化に対するミトコンドリア鉄蓄積と鉄取り込み機構の関与2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子, 藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation]2012
- Author(s)
  関根秀一、薄田健史、荻村栄一郎、堀江利治
- Organizer
  BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立第27年会日本薬剤学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation]2012
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  酸化ストレス誘発性胆汁っ滞時における胆汁排泄輸送体の局在制御機構の解明肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込みの関与2012
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第２０回　肝病態生理研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich-cultured hepatocytes enable a predictive evaluation of BSEP/Bsep dysfunction-mediated2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  drug-induced hepatotoxicity SOT
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子, 藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Inhibitory effects of high-dose tea cathechins on multidrug resistance associated protein 2 (MRP2) function,2012
- Author(s)
  Emi Okubo, Kenichi Wakabayashi, Toshio Kasamatsu, Naohiro Nishiyama, Shuichi Sekine, Toshiharu Horie
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwich cultured rat hepatocytes2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  MDO-ISSX
- Place of Presentation
  Noordwijk aan Zee, The Netherlands
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与2012
- Author(s)
  小澤口尚子,関根秀一,堀江利治
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根　秀一、薄田　健史、荻村　栄一郎、堀江利治
- Organizer
  日本薬剤学会　第２７年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwich cultured rathepatocytes2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  Noordwijk aan Zee
- Place of Presentation
  The Netherlands
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与2012
- Author(s)
  小澤口尚子、関根秀一、堀江利治
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込みの関与2012
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第２０回　肝病態生理研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation]2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛
- Organizer
  新澤靖子C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与2012
- Author(s)
  伊藤好美、関根秀一、堀江利治
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 生体成分共存下におけるカテキンの安定性とROSの生成2012
- Author(s)
  大久保江美、関根秀一、若林賢一、笠松俊夫、西山直宏、堀江利治
- Organizer
  第20回年会日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  仙台
- Year and Date
  2012-08-25
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich culutured rat hepatocytes を用いた胆汁酸依存性薬剤肝障害の定量的評価法2011
- Author(s)
  荻村栄一朗, 関根秀一,堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサート誘発性消化管バリア機能障害における好中球浸潤の関与2011
- Author(s)
  書川尚子,関根秀一,浅田千晶、前田智子、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵、関根秀一、三ツ木香織、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Fexofenadineとcyclosporin Aの消化管吸収過程で生じるトランスポーターを介した薬物間相互作用2011
- Author(s)
  鈴木敬,設楽悦久,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス誘発性胆汁鬱滞におけるMRP2の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス誘発性胆汁うっ滞時におけるMRP2の局在制御機構の解明2011
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗, 関根秀一, 堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝炎時の胆汁排泄輸送体Mrp2の内在化機構の解明2011
- Author(s)
  佐伯淳二郎、関根秀一、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与2011
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Quantitative evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes2011
- Author(s)
  荻村栄一朗, 関根秀一, 堀江利治
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵,関根秀一,三ツ木香織、伊藤晃成、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与2011
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Phenforminによる毒性に対するミトコンドリア輸送担体の関与の解明2011
- Author(s)
  則岡美咲、設楽悦久、中道範隆、加藤将夫、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Sandwich culutured rat hepatocytesを用いた胆汁酸依存性薬剤肝障害の定量的評価法2011
- Author(s)
  荻村栄一朗, 関根秀一, 堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 癌細胞の多剤耐性におけるPDZタンパク質の関与2011
- Author(s)
  長里美希,関根秀一、日比野翔、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する鉄蓄積の関与2011
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子, 藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Phenforminによる毒性に対するミトコンドリア輸送担体の関与の解明2011
- Author(s)
  則岡美咲,設楽悦久,中道範隆,加藤将夫,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗,関根秀一,堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する鉄蓄積の関与2011
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Sandwich cultured rat hepatocytes を用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗, 関根秀一,堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] POTENTIAL P-GLYCOPROTEIN MEDIATED DRUG-DRUG INTERACTIONS OF SOME ANTI-MALARIALS2011
- Author(s)
  Enoche F.Oga、関根秀一、設楽悦久、堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵,関根秀一,三ツ木香織、伊藤晃成、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  日東
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝障害誘発性薬物による肝毒性に対する肝ミトコンドリア中のグルタチオン量の関与2011
- Author(s)
  小澤口尚子,関根秀一,堀江利治
- Organizer
  第19年会日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  仙台
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Fexofenadineとcyclosporin Aの消化管吸収過程で生じるトランスポーターを介した薬物間相互作用2011
- Author(s)
  鈴木敬、設楽悦久、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス誘発性胆汁鬱滞におけるMRP2の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝炎症時の胆汁排泄輸送体Mrp2の内在化機構解明2011
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] フェンホルミンによって引き起こされるミトコンドリア障害に対するOCTN1/Octn1の関与2011
- Author(s)
  菊田奈津子、設楽悦久、則岡美咲、中道範孝、加藤将夫、堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 肝炎症時の胆汁排泄輸送体Mrp2の内在化機構解明2011
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する徹蓄積の関与2011
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] シクロスポリンAによる肝トランスポータ-OATPの阻害機序の解析2010
- Author(s)
  竹内久美子、設楽悦久、永松佳子、和田怜美、杉山雄一、堀江利治
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Bsep局在スクリーニング系構築による薬剤誘発性Bsep内在化機構の解明2010
- Author(s)
  荻村栄一朗,関根秀一,堀江利治
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝臓及び小腸におけるEstradiol 17β-glucuronide誘発性Mrp2機能低下機構の解明.2010
- Author(s)
  松尾玲子, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Regulatory mechanism of drug-induced Bsep internalization by construction of screening system for Bsep internalization2010
- Author(s)
  Eiichiro Ogimura, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Mitochondrial uptake of organic cations as one of determinants of liver specific toxicity by phenformin2010
- Author(s)
  Misaki Norioka, Yoshihisa Shitara, Toshiharu Horie
- Organizer
  Pharmaceutical Sciences 2010 World Congress/AAPS annual meeting and exposition
- Place of Presentation
  Morial Convention Center, New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸におけるMRP2,MDR1発現部位差に対するezrinの関与2010
- Author(s)
  中埜貴文,関根秀一,伊藤晃成,堀江利治
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬剤性ミトコンドリア障害感受性における動物種差の検討2010
- Author(s)
  本山碧、関根秀一、木村友映、堀江利治
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山国際会議場
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサートによる小腸上皮バリア機能障害の機序解析.2010
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS-induced Mrp2 internalization is due to the dissociation of Mrp2 and radixin2010
- Author(s)
  Junjiro Saeki, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] The effect of dimerumic acid on LPS-induced internalization of MRP2 inhuman liver2010
- Author(s)
  Toshiharu Horie, Shuichi Sekine
- Organizer
  International Conference on Gastroenterology(Gastroenterology'10)
- Place of Presentation
  Malta
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆汁うっ滞時のMrp2機能低下に対するジメルミン酸の抑制効果について2010
- Author(s)
  矢野健太郎,関根秀一,根本華奈子,不破亨,堀江利治
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸におけるMrp2, Mdrl発現部位差とezrinの発現、リン酸化状態の部位差との関連2010
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆汁うっ滯時のMrp2機能低下に対するジメルミン酸の抑制効果について.2010
- Author(s)
  矢野健太郎, 関根秀一, 根本華奈子, 不破亨, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Canalicular Mrp2 localization is reversibly regulated by the phosphorylation status of its anchoring protein_2010
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  9th International ISSX meeting
- Place of Presentation
  Istanbul, Tukery
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2010
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] ラットにおけるclofibrate投与による有機アニオントランスポーターOatpの活性変動の機序解析2010
- Author(s)
  和田怜美, 設楽悦久, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性Mrp2内在化におけるMrp2-radixin間相互作用解消の関与2010
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸炎症時における薬剤排泄トランスポーターMrp2の機能制御機構の解明.2010
- Author(s)
  小島亮人, 関根秀一, 中埜貴文, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2010
- Author(s)
  関根秀一、設楽悦久、堀江利治
- Organizer
  37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Effect of CYP3A inhibitors on troglitazone-induced mitochondrial toxicity2010
- Author(s)
  Yoshihisa Shitara, Toshiharu Horie
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Long-lasting inhibition of human organic anion transporting polypeptides 1B1 and 1B3 by cyclosporin A2010
- Author(s)
  Yoshihisa Shitara, Kumiko Takeuchi, Satomi Wada, Yoshiko Nagamatsu, Yuichi Sugiyama, Toshiharu Horie
- Organizer
  Pharmaceutical Sciences 2010 World Congress/AAPS annual meeting and exposition
- Place of Presentation
  Morial Convention Center, New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] ラット肝ミトコンドリアにおける有機アニオン性化合物取り込みの解析2010
- Author(s)
  藤野亮、設楽悦久、堀江利治
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Ezrin has a key role in the expression profile of MRP2 and MDR1 along intestinal tract2010
- Author(s)
  Shuichi Sekine, Kousei Ito, Takafumi, Nakano, Toshiharu Horie
- Organizer
  9th International ISSX meeting
- Place of Presentation
  Istanbul, Tukery
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Mitochondrial uptake of organic cations as one of determinants of phenformin-induced lactic acidosis2010
- Author(s)
  Misaki Norioka, Yoshihisa Shitara, Noritaka Nakamichi, Yukio Kato, Toshiharu Horie
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] The role of Nrf2 on multidrug resistance2010
- Author(s)
  Masahiro Ono, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質により誘発される酸化ストレスに対する鉄蓄積の関与2010
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第18回生体パーオキサイド研究会
- Place of Presentation
  仙台
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Intracellular redox status reversibly regulates the localization of Mrp2-radixin complex.2009
- Author(s)
  Sekine, S., Ito, K., Horie, T.
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサートによる小腸上皮透過性亢進の機序検討.2009
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬剤学会第24年会講演要旨集
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] The mechanisms of enhanced paracellular permability in the small intestine of MTX-treated rats.2009
- Author(s)
  Hamada, K, Shitara, Y, Sekine, S, Horie, T.
- Organizer
  Advances in Inframmatory Bowel Diseases Crohn's & Colitis Foundation's & Clinical Conference
- Place of Presentation
  Hollywood, USA
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性Mrp2局在変化へのRadixinの脱リン酸化の関与2009
- Author(s)
  佐伯淳二郎,関根秀一,月田早智子,堀江利治
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2009
- Author(s)
  三ツ木香織、関根秀一、堀江利治
- Organizer
  第129年会日本薬学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] フェンホルミンのミトコンドリア毒性に対する有機カチオン輸送系の関与.2009
- Author(s)
  則岡美咲, 設楽悦久, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 免疫仰制薬シクロスポリンおよびタクロリムによるOATP1B1およびOATP1B3に対する阻害効果の比較検討.2009
- Author(s)
  設楽悦久, 竹内久美子, 和田怜美, 永松佳子, 杉山雄一, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] フェンホルミンの肝毒性に対するミトコンドリア有機カチオン輸送担体の関与2009
- Author(s)
  則岡美咲, 設楽悦久, 堀江利治
- Organizer
  第3回次世代を担う若手医療科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] シクロスポリンによるOATP1B1およびOATP1B3の持続的阻害2009
- Author(s)
  設楽悦久, 竹内久美子, 和田怜美, 永松佳子, 杉山雄一, 堀江利治
- Organizer
  第3回次世代を担う若手医療科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性Mrp局在変化へのRadixinの脱リン酸化の関与.2009
- Author(s)
  佐伯淳二郎, 関根秀一, 月田早智子, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸におけるMrp2発現部位差とezrinリン酸化状態との関連.2009
- Author(s)
  中埜貴文, 関根秀一, 伊藤晃成, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Oxidative stress contributes to Methotrexate-induced small intestinal in jury caused by neutrophil infiltration.2009
- Author(s)
  Asada, C., Sekine, S., Miyazono, Y., Maeda, T., Horie, T
- Organizer
  The 1st International Conference on Lipid Hydroperoxide Byology and Medicine Sendai (ICLH2009)
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆汁うっ滯におけるDimerumic acidの抑制効果について.2009
- Author(s)
  矢野健太郎, 関根秀一, 根本華奈子, 不破亨, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Mrp2 localization is reversibly regulated by protein kinases2007
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Mrp2 localization is reversibly regulated by protein kinases2007
- Author(s)
  Sekine S, Ito K, Horie T
- Organizer
  8th International ISSX
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Tha phosphorylation status of ezrin regulates MrP2 localization in rat intestine2007
- Author(s)
  Takahumi Nakano, Shuichi Sekine.Kousei Ito, Toshiharu Horie
- Organizer
  8th Intemational ISSX
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] PKA/PKC活性化平衡の変動によるMrp2の可逆的膜動輸送制御について2007
- Author(s)
  関根秀一, 伊藤晃成, 堀江利治
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Tha phosphorylation status of ezrin regulates Mrp2 localization in rat intestine2007
- Author(s)
  Takahumi Nakano, Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] 小腸上皮Mrp2の膜局在と膜裏打ち蛋白質Ezrinのリン酸化状態との関連2007
- Author(s)
  中埜貴文, 関根秀一, 伊藤晃成, 堀江利治
- Organizer
  日本薬学会第126年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Tha phosphorylation status of ezrin regulates Mrp2 localization in rat intestine2007
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T
- Organizer
  8th International ISSX
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Phosphorylation status of ezrin correlates with membrane localization of Mrp2 in intestine2007
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Organizer
  126th meeting of pharmaceutical society of japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Mrp2 localization is reversibly regulated by protein kinases.2007
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] The balance of PKA/PKC activation reversibly regulates vesicular trafficking of Mrp22007
- Author(s)
  Sekine S, Ito K, Horie T
- Organizer
  29th Symposium on biomembrane-drug interaction
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与
- Author(s)
  釘岡里恵、関根秀一、三ツ木香織、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会　第２６年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与
- Author(s)
  小澤口尚子、関根秀一、堀江利治
- Organizer
  日本薬学会　第１３２年会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes
- Author(s)
  Sekine S, Ogimura E, Horie T.
- Organizer
  51th　Society of Toxicology meeting
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Quantitative evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes
- Author(s)
  荻村栄一朗，関根秀一，堀江利治
- Organizer
  日本薬物動態学会　第２６回年会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 生活習慣病モデル動物を用いたミトコンドリア薬物感受性の解析
- Author(s)
  濱田　和真、中埜　貴文、堀江　利治
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール(兵庫県神戸市)
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26670084
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第３８回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価
- Author(s)
  荻村栄一朗，関根秀一，堀江利治
- Organizer
  第３８回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス誘発性胆汁うっ滞時におけるMRP2の局在制御機構の解明
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  第３３回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎とポルフィリン症の関連性についての解析
- Author(s)
  中埜　貴文、濱田　和真、森屋　恭爾、小池　和彦、堀江　利治
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール(兵庫県神戸市)
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26670084

1. HAYASHI Masahiro (20012669)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. AWAZU Shoji (60012621)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. MASUBUCHI Yasuhiro (10209455)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
4. SHITARA Yoshihisa (00306656)

# of Collaborated Projects: 4 results

# of Collaborated Products: 60 results
5. SEKINE Shuichi (70401007)

# of Collaborated Projects: 4 results

# of Collaborated Products: 144 results
6. ITO Kousei (30323405)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
7. HAMADA Kazuma (90596884)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. NAKANO Takafumi (40720793)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
9. MIZUMA Takashi (80229715)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TOMITA Mikio (60207610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KAIHO Fusao (10120180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 森屋恭爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HORIE Toshiharu 堀江 利治

Research Projects

Research Products

Co-Researchers

C型肝炎時の肝細胞内ヘム代謝に着目した薬剤性肝障害メカニズムの解明Principal Investigator

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Analysis of idiosyncratic drug toxicity using mitochondria isolated from an animal model of metabolic syndromePrincipal Investigator

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Quantitative analysis of drugs induced BSEP inhibition and cholestatic hepatotoxicityPrincipal Investigator

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Molecular analysis of localization of biliary transporters in chronic hepatitisPrincipal Investigator

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Intrahepatic imaging and molecular analysis of MRP2 localization regulated by the intracellular redox statusPrincipal Investigator

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MRP2 mediated defense against oxidative stress in liverPrincipal Investigator

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Role of Mitochondria as Signal Sensors in Drug-Induced Liver Injury

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Involvement of cytokines in drug-induced liver injury

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Evaluation of drug-induced hepatotoxicity by chemiluminescence and the role of MRP2 in the hepatotoxicityPrincipal Investigator

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The drug-induced hepatotoxicityPrincipal Investigator

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Pharmacokinetics and Hepatotoxicity due to the oxidative stressPrincipal Investigator

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Improvemrnt of Drug Absorption in Gastro intestinal Tract

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A Study on Protective Effect of Vitamin A against Antitumour Drug-Induced Damage to Small IntestinePrincipal Investigator

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HORIE Toshiharu 堀江利治

[Book] 「最新薬剤学第10版」、林正弘、尾関哲也、乾賢一編2012