FUKAI Fumio 深井文雄

Researcher Number	90124487
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016: 東京理科大学, 薬学部・生命創薬科学科, 教授 2012: 東京理科大学, 薬学部・生命創薬科学科, 教授 2010 – 2012: 東京理科大学, 薬学部, 教授 2004 – 2008: Tokyo University of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 2001 – 2003: Tokyo University of Science, Fac. ofPharm., Asso. Prof., 薬学部, 助教授 … More 1999 – 2000: 東京理科大学, 薬学部, 講師 1993 – 1995: Science Univ.of Tokyo, 薬学部, 講師 1993: 東京理科大学, 薬学部・臨床病態学, 講師 1992: 東京理科大学, 薬学部・臨床病態学教室, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / 医薬分子機能学 / Structural biochemistry / Cell biology / 物質生物化学 Except Principal Investigator Pathological medical chemistry / Chemistry related to living body / 高分子構造・物性(含繊維) / Hematology / Biomedical engineering/Biological material science / Biological Sciences
Keywords	Principal Investigator フィブロネクチン / インテグリン / 接着 / fibronectin / MAPK / Ras / アポトーシス / 細胞死 / adhesion / Integrin … More / Fibronectin / receptor / レセプター / フィブロネクチンフラグメント / 細胞増殖 / 悪性腫瘍 / 細胞接着 / Apoptosis / Programmed cell death / Adhesion / Tenascin / MAP-Kinase pathway / シンデカン / M / G2 / MAPキナーゼ / テネシン / anoikis / extracellular marti* / apoptosis / cell death / integrin / anticancer drug / 抗癌剤 / アノイキス / 細胞外マトリックス / 抗がん剤 / phosphorylation / peptide / antiadhesion / ペプチド / 受容体 / 反接着 / Glycosaminoglycan / Proteoglycan / Cell adhesion / Adhesion molecule / Fibronectin receptor / Adipocyte differentiation / コンドロイチン硫酸 / グリコサミノグリカン / プロテオグリカン / 接着分子 / 分化 / 脂肪細胞 / calpain / cell differentiation / matrix metalloproteinase / protease / cell migration / fibrofnectin fragment / 炎症 / マトリックスメタロプロティナーゼ / カルパイン / 細胞分化 / マトリックスメタロプロテイナーゼ / プロテアーゼ / 細胞遊走 / がん / テネイシン / 悪性転換 / PDGF / 神経膠芽腫 / テネイシンC / 細胞生物学 … More Except Principal Investigator ナノ粒子 / ABCG1 / ABCA1 / 泡沫化 / インテグリン / 動脈硬化病態形成 / 炎症 / 動脈硬化 / マクロファージ / 細胞外マトリックス / テネイシンC / Antimicrobial activities / Biological activities / Physicochemical properties / Self-assembly / Supramolecular complexes / Iodine / Nanoparticles / Chitosan / 抗腫瘍効果 / 抗菌作用 / 生理活性 / 物理化学的性質 / 自己集合 / 超分子錯体 / ヨウ素 / キトサン / Biological Functionality / Molecular Assembly / Thermal Hystereisis Behavior / Molecular Simulation / Structural Analysis / Spectroscopic Properties / Chitosan-Iodine Compley / Polysaccharide / 温度履歴挙動 / 生理機能 / 分子集合 / 熱履歴挙動 / 分子シミュレーション / 構造解析 / 分光特性 / キトサン・ヨウ素錯体 / 多糖類 / テネシンーC / 輸血製剤 / 造血幹細胞 / ペプチド / テネシン－Ｃ / 輸血学 / 制癌剤 / トレハロース / PLGA / ナノコンポジット微粒子 / 経肺吸収 / 肺がん / 経気道投与 / DDS / 経肺吸収製剤 / がん / 薬学 / 薬物送達システム / 分子標的療法 / 急性骨随性白血病 / フィブロネクチン由来ペプチド Less

Macrophage Foam Cell Formation Induced by the Peptide Derived from Tenascin-C
- Principal Investigator
  
  IYODA Takuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo University of Science
Molecular mechanism for malignant cell transformationinduced by a peptide derived from tenascin C through integrin activationPrincipal Investigator
- Principal Investigator
  
  FUKAI Fumio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Science
Development of transfusion products derived from hematopoietic stem cells using TNIII14 peptide
- Principal Investigator
  
  KUBUKI Yohko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Miyazaki
Pulmonary delivery of nanocomposite particles for the treatment oflung carcinoma
- Principal Investigator
  
  MAKINO Kimiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo University of Science
フィブロネクチン由来ペプチドを用いた急性骨髄性白血病の新しい分子標的療法の開発
- Principal Investigator
  
  MATSUNAGA Takuya
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Induction of programmed death of tumor cells by activation of betal integrin.Principal Investigator
- Principal Investigator
  
  FUKAI Fumio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Science
Self-assembly of the Supramolecular Complexes of Chitosan-Nanoparticles Hybrid Composites with Iodine and Their Biological activities
- Principal Investigator
  
  YAJIMA Hirofumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tokyo University of Science
Sensitization of cancer cells to anti-cancer drugs by the integrin function-suppressing peptide FNIII14.Principal Investigator
- Principal Investigator
  
  HUKAI Humio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Science
Investigation of the Supramolecular Formation and Temperature Hysteresis Behavior of Chitosan-Iodine Complex and the Evaluation of Its Biological functionality
- Principal Investigator
  
  HIROFUMI Yajima
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  高分子構造・物性(含繊維)
- Research Institution
  Tokyo University of Science
Identification of a membrane receptor mediating the biological effects of the fibronectin-derivedantiadhesive peptide FNIII 14.Principal Investigator
- Principal Investigator
  
  FUKAI Fumio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Science University of Tokyo
Adipocyte differentiation of ST-13 cells induced by fibronectin fragmentPrincipal Investigator
- Principal Investigator
  
  FUKAI Fumio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
Molecular mechanism of fibronectin-induced chemotactic migrationPrincipal Investigator
- Principal Investigator
  
  FUKAI Fumio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo

All 2016 2015 2012 2011 2010 2006 2005

All Journal Article Presentation Book Patent

[Book] Cell regulation through membrane raft/caveolae in Electrical Phenomena at Interfaces and Biointerfaces: Fundamentals and Applications in Nano-, Bio-, and Environmental Sciences2012
- Author(s)
  Yohei Saito, Toshiyuki Owaki, and Fumio Fukai
- Publisher
  John Wiley & Son
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article] Promotion of Macrophage Foam Cell Formation by the Peptide Derived from Tenascin-C2016
- Author(s)
  Iyoda T, Fukai F
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 203-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19034
[Journal Article] Modulation of tumor cell survival, proliferation, and differentiation by the peptide derived from tenascin-C2012
- Author(s)
  Iyoda, T., and Fukai, F
- Journal Title
  
  Int. J Cell Biol. 2012
  
  Volume: Article ID 647594 Pages: 10-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article]2012
- Author(s)
  Matsunaga T, Fukai F, Kameda T, Shide K, Shimoda H, Torii E, Kamiunten A, Sekine M, Yamamoto S, Hidaka T, Kubuki Y, Yokokura S, Uemura M, Matsuoka A, Waki F, Matsumoto K, Kanaji N, Ishii T, Imataki O, Dobashi H, Bandoh S, Shimoda K.
- Journal Title
  
  Ann Hamatol
  
  Volume: 91(10) Pages: 1633-1643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article] Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment2012
- Author(s)
  Itagaki, K., Naito, T., Iwakiri, R., Haga, M., Miura S., Saito Y., Owaki, T., Kamiya, S., Iyoda, T., Yajima, H., Iwashita, S., Ejiri, S., and Fukai, F.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 16037-16046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article] The cell adhesion and proliferation activities of a peptide derived from human tenascin-C are dependent on two Ile residues2012
- Author(s)
  Hayashi R., Miura, S., Saito Y., Osada S., Iyoda, T., Fukai, F., and Kodama H
- Journal Title
  
  Bioorg. Med Chem
  
  Volume: 20 Pages: 4608-4613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article] Elevated HIF-1αexpression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy2012
- Author(s)
  Matsunaga T, Imataki O, Torii E, Kameda T, Shide K, Shimoda H, Kamiunten A, Sekine M, Taniguchi Y, Yamamoto S, Hidaka T, Katayose K, Kubuki Y, Dobashi H, Bandoh S, Ohnishi H, Fukai F, Shimoda K.
- Journal Title
  
  Leukemia Res
  
  Volume: 36 Pages: 122-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article] Modulation of tumor cell survival, proliferation, and differentiation by the peptide derived from tenascin-C.2012
- Author(s)
  Iyoda, T., and Fukai, F.
- Journal Title
  
  Int. J. Cell Biol.
  
  Volume: 2012
- Data Source
  KAKENHI-PROJECT-23590090
[Journal Article] Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation.2012
- Author(s)
  MatsunagaT, FukaiF, KamedaT, ShideK, ShimodaH, Torii E, KamiuntenA, SekineM, YamamotoS, HidakaT, KubukiY, YokokuraS, UemuraM, MatsuokaA, WakiF, MatsumotoK, KanajiN, IshiiT, ImatakiO, DobashiH, BandohS, ShimodaK
- Journal Title
  
  Ann Hematol
  
  Volume: 91 (10) Pages: 1633-1643
- Data Source
  KAKENHI-PROJECT-22591066
[Patent] 抗白血病活性増強剤2006
- Inventor(s)
  深井文雄, 新津洋司郎
- Industrial Property Rights Holder
  学校法人東京理科大学
- Filing Date
  2006-12-07
- Data Source
  KAKENHI-PROJECT-17590074
[Patent] 抗がん剤2006
- Inventor(s)
  深井文雄
- Industrial Property Rights Holder
  学校法人東京理科大学
- Patent Publication Number
  2006-249031
- Filing Date
  2006-09-21
- Data Source
  KAKENHI-PROJECT-17590074
[Patent] シンデカン-4の活性化剤2005
- Inventor(s)
  深井文雄
- Industrial Property Rights Holder
  学校法人東京理科大学
- Industrial Property Number
  2005-217756
- Filing Date
  2005-07-27
- Data Source
  KAKENHI-PROJECT-17590074
[Patent] 抗癌剤2005
- Inventor(s)
  深井文雄
- Industrial Property Rights Holder
  東京理科大学
- Filing Date
  2005-03-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590074
[Presentation] 微小接着環境の変化に伴うマクロファージの機能調節と動脈硬化病態の形成2016
- Author(s)
  伊豫田拓也，深井文雄
- Organizer
  再生医療とDDSの融合研究部門シンポジウム
- Place of Presentation
  東京（東京理科大学森戸記念館）
- Year and Date
  2016-12-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] テネイシンC分子内領域 TNIIIA2 によるマクロファージの機能調節と泡沫細胞化2016
- Author(s)
  伊豫田拓也，深井文雄
- Organizer
  MatriCell フォーラム
- Place of Presentation
  東京（Porta神楽坂）
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] 細胞外マトリックス環境と生活習慣病2016
- Author(s)
  伊豫田拓也，深井文雄
- Organizer
  日本医科大学・東京理科大学合同シンポジウム
- Place of Presentation
  東京（日本医科大学橘桜会館）
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] ROLE OF THE TNIIIA2 SITE IN TENASCIN-C IN THE PROGRESSION OF ATHEROSCLEROSIS2016
- Author(s)
  Iyoda T, Fukai F
- Organizer
  The 4th International Postgraduate Conference on Pharmaceutical Sciences 2016
- Place of Presentation
  Noda, Chiba
- Year and Date
  2016-02-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] テネイシンC分子内領域によるマクロファージ泡沫化の亢進2015
- Author(s)
  伊豫田拓也，深井文雄
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  船橋、千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] 細胞外マトリックス由来ペプチドによるマクロファージ機能と動脈硬化病態の調節2015
- Author(s)
  伊豫田拓也，深井文雄
- Organizer
  第133回日本薬理学会関東支部会
- Place of Presentation
  柏、千葉
- Year and Date
  2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] テネイシンC由来ペプチド TNIIIA2 によるマクロファージ泡沫細胞化の亢進2015
- Author(s)
  伊豫田拓也，深井文雄
- Organizer
  第47回日本結合組織学会学術大会
- Place of Presentation
  品川、東京
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] Promotion of macrophage foam cell formation by the peptide derived from tenascin-C2015
- Author(s)
  Iyoda T, Fukai F
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚、神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K19034
[Presentation] 細胞接着分子を標的とした新しい治療薬の開発2012
- Author(s)
  深井文雄
- Organizer
  第23回新薬創製談話会
- Place of Presentation
  熱海
- Year and Date
  2012-09-11
- Data Source
  KAKENHI-PROJECT-23590090
[Presentation] テネイシンC分子由来のインテグリン活性化ペプチドによる神経膠芽腫細胞のPDGF依存性増殖、移動能の過剰増強2012
- Author(s)
  藤田元道、藤澤達也、伊豫田拓也、深井文雄
- Organizer
  日本薬学会第132年会(北海道大学
- Place of Presentation
  札幌(横浜)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23590090
[Presentation] テネイシンC分子由来のインテグリン活性化ペプチドによる神経膠芽腫細胞のPDGF依存性増殖、移動能の過剰増強2012
- Author(s)
  藤田元道、藤澤達也、伊豫田拓也、深井文雄
- Organizer
  第2回テネイシンフォーラム
- Place of Presentation
  東京理科大学・森戸記念館
- Year and Date
  2012-11-10
- Data Source
  KAKENHI-PROJECT-23590090
[Presentation] Cell Regulation by Cryptic Functional Sites in Fibronectin and Tenascin-C Molecules2011
- Author(s)
  Fumio Fukai
- Organizer
  10th Osteopontin Meeting(招待講演)
- Place of Presentation
  Hokkaido University
- Data Source
  KAKENHI-PROJECT-23590090
[Presentation] Cell regulation by cryptic functional sites in fibronectin and tenascin-C molecules2011
- Author(s)
  Fumio Fukai
- Organizer
  10th Osteoponchin meeting
- Place of Presentation
  北海道大学医学部、札幌
- Year and Date
  2011-06-19
- Data Source
  KAKENHI-PROJECT-23590090
[Presentation] テネイシン C 由来のペプチドTNIIIA2 は PDGF 依存性の細胞増殖を過度に促進する2011
- Author(s)
  大塚一樹、藤澤達也、伊豫田拓也、深井文雄
- Organizer
  第1回テネイシンフォーラム
- Place of Presentation
  三重大学医学部
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-23590090
[Presentation] VLA4とVLA5を介したフィブロネクチンへの接着は巨核球のproplatelet形成を促進する2010
- Author(s)
  松永卓也, 深井文雄, 久冨木庸子, 下田和哉, 他
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22591066
[Presentation] VLA4 と VLA5 を介したフィブロネクチンへの接着は巨核球の proplatelet 形成を促進する2010
- Author(s)
  松永卓也,深井文雄,久冨木庸子,下田和哉,他
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22591066

1. KATAYAMA Takashi (00013897)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. HIROFUMI Yajima (10147506)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MATSUNAGA Takuya (70260768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. TERADA Hiroshi (00035544)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. IYODA Takuya (80465715)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. 杣源一郎 (00158990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MAKINO Kimiko (40147509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUBUKI Yohko (00284836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SHIMODA Kazuya (90311844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. HITOSHI Sashiwa (20205884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKESHI Kikuchi (90195206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KAWAI Takeshi (10224718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KODAMA Hiroaki (80205418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAGAWA Yoshimi (80361351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 友田敬士郎 (70516400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 廣田慶司 (50516359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 伊藤史典 (10366429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SONAVANE Ganeshchandra (90449231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

FUKAI Fumio 深井 文雄

Research Projects

Research Products

Co-Researchers

Macrophage Foam Cell Formation Induced by the Peptide Derived from Tenascin-C

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism for malignant cell transformationinduced by a peptide derived from tenascin C through integrin activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of transfusion products derived from hematopoietic stem cells using TNIII14 peptide

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pulmonary delivery of nanocomposite particles for the treatment oflung carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

フィブロネクチン由来ペプチドを用いた急性骨髄性白血病の新しい分子標的療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of programmed death of tumor cells by activation of betal integrin.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Self-assembly of the Supramolecular Complexes of Chitosan-Nanoparticles Hybrid Composites with Iodine and Their Biological activities

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sensitization of cancer cells to anti-cancer drugs by the integrin function-suppressing peptide FNIII14.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the Supramolecular Formation and Temperature Hysteresis Behavior of Chitosan-Iodine Complex and the Evaluation of Its Biological functionality

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a membrane receptor mediating the biological effects of the fibronectin-derivedantiadhesive peptide FNIII 14.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adipocyte differentiation of ST-13 cells induced by fibronectin fragmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of fibronectin-induced chemotactic migrationPrincipal Investigator

Principal Investigator

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[Book] Cell regulation through membrane raft/caveolae in Electrical Phenomena at Interfaces and Biointerfaces: Fundamentals and Applications in Nano-, Bio-, and Environmental Sciences2012

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FUKAI Fumio 深井文雄