ISHI Kunio 石井邦雄

… Alternative Names

Researcher Number	90137993
Affiliation (Current)	2021: 北里大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 横浜薬科大学, 薬学部, 教授 2009 – 2014: Kitasato University, 薬学部, 教授 2005 – 2006: 北里大学, 薬学部, 教授 1997 – 2001: Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Sh, 薬学部, 教授 1997: 北里大学, 薬学部, 助教授(教授) … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy / Medical pharmacy / General pharmacology Except Principal Investigator Biological pharmacy / General pharmacology / 医薬分子機能学
Keywords	Principal Investigator 糖尿病 / 微小循環 / 薬理学 / 網膜 / 血管生物学 / 網膜循環 / fura 2 / ラット / 網膜細動静脈 / 血管径 … More Except Principal Investigator バイオメカニクス / 血管 / 筋原性収縮 / セロトニン / ニューロペプチドY / プロテインキナーゼC / Ca^<2+>チャネル / 脳・冠動脈 / 物理受容 / ストレッチ / 血管収縮 / 物理受容・応答 / tyrosine kinase / stretch / myogenic contraction / ブタ冠動脈 / イヌ脳動脈 / エンドセリン-1 / 急速伸展刺激 / エンドセリン / カルシウム感受性 / ミオシン軽鎖リン酸化 / 複合刺激 / ストレッチ反応 / カルシウムイオン / イノシトール3リン酸 / ホスホリパーゼC / 細胞内遊離【Ca^(2+)】濃度,【Ca^(2+)】取り込み,脱感作,C-キナーゼ,副腎髄質クロマフィン細胞. / 腫瘍プロモーション / C-キナーゼ / 合成ジアシルグリセロール / ホルボールエステル / HL-60細胞 / 伸展刺激 / フォスフォリパーゼC / カルシウムシグナリング / 物理情報 / 圧負荷 / 筋原性収縮反応 / アーテリオグラフ / モノクロタリン肺高血圧 / Cerebral and Coronary Artery / Biomechanics / Stretch / Stretch Activation / Mechanical Receptor / Vascontraction / Phopspholipase C / Ca^<2+> Signaling / チロシンキナーゼ / チロシンリン酸化 / 接着因子 / 細胞情報伝達 / cerebral artery / myogenic tone / tyrosine kinase inhbitor / genistein / tyrphostin 23 / herbimycin A / intracellular signaling / mechano-reception / vascular tissue / protein tyrosyl phosphorylation / adhesion molecule / cellar signal transduction / 循環 / 血行力学刺激 / チロシンリン酸化酵素 / 実験治療学 / 細胞シグナリング / 循環系 / チロシンキナーゼ阻害薬 / 細胞内情報伝達 / 接着班キナーゼ活性 / mechano-transduction / biomechanics / tyrosine kinase inhibitor / protein tyosyl phosphorylation / cardiovascular system / hemodynamics / pressure Less

Mechanisms of neuronal-glial-vascular interactions in the retina and the development of novel strategies for treating retinal diseasesPrincipal Investigator
- Principal Investigator
  
  ISHII Kunio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama College of Pharmacy
Elucidation of mechanisms for regulating retinal circulation and identification of target molecule for novel preventive and/or therapeutic drugs for retinopathyPrincipal Investigator
- Principal Investigator
  
  ISHII Kunio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Elucidation of the molecular basis attributed to onset of abnormal retinal hemodynamics and strategy of novel prevention drugs for retinopathyPrincipal Investigator
- Principal Investigator
  
  ISHII Kunio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
動的光散乱法を中心とした糖尿病性白内障進展過程の解析と予防薬/治療薬開発への応用Principal Investigator
- Principal Investigator
  
  石井邦雄
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kitasato University
Development of high-resolution digital fundus camera for small animals and application of it to studies on analysis of responsiveness of retinal blood vesselsPrincipal Investigator
- Principal Investigator
  
  ISHII Kunio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Studies on responsiveness of rat retial blood vessels with a newly developed digital funduscope system for small animalsPrincipal Investigator
- Principal Investigator
  
  ISHII Kunio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Development of the modulator drug specifically targeting biomechanical reaction in the circulatory system and the application for experimental therapeutics.
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  University of Shizuoka
Studies on changes in the pancreatic B cell function during development and aging assessed by computer-aided fluorescent microscopyPrincipal Investigator
- Principal Investigator
  
  ISHI Kunio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
  University of Shizuoka
Specific role of tyrosine kinase in the vascular contraction produced by stretch.
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Shizuoka
脈管系におけるバイオメカニクス反応と薬物による制御
- Principal Investigator
  
  中山貢一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
血管〓縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序
- Principal Investigator
  
  中山貢一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Shizuoka
Reguratory mechanism of hypotensive responses to muscarinic cholinergic stimulation through the adrenergic receptor system.Principal Investigator
- Principal Investigator
  
  ISHII Kunio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
血管攣縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Shizuoka
Sutudy of vascular reactions in response to hemodynamic factors assessed by stretch activation
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Uuniversity of Shizuoka
副腎クロマフィン細胞における受容体刺激に伴うカルシウムイオン流入の急速脱感作機構
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Keio University
腫瘍プロモーターTPAの作用機序に関する研究
- Principal Investigator
  
  山本慧
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University

All 2018 2017 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] Elucidation of Dysfunctional Mechanisms of Retinal Circulation in the Rat Models of Glaucoma and Exploration of Novel Therapeutic Drugs2018
- Author(s)
  Mori A, Nakahara T, Kurauchi Y, Sakamoto K, Ishii K.
- Journal Title
  
  薬学雑誌
  
  Volume: 133 Issue: 12 Pages: 1343-1350
- DOI
  10.1248/yakushi.13-00228-2
- NAID
  130003382289
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-09-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24790261
[Journal Article] Stimulation of β1- and β2-adrenoceptors dilates retinal blood vessels in rats.2017
- Author(s)
  Mori A, Sekito A, Sakamoto K, Ishii K, Nakahara T
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol.
  
  Volume: 390 Pages: 527-533
- DOI
  10.1007/s00210-017-1349-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460103, KAKENHI-PROJECT-16K08554, KAKENHI-PROJECT-15K07971, KAKENHI-PROJECT-15K08242
[Journal Article] Probucol prevents the attenuation of β2-adrenoceptor-mediated vasodilation of retinal arterioles in diabetic rats.2017
- Author(s)
  Mori A, Higashi K, Wakao S, Sakamoto K, Ishii K, Nakahara T.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol.
  
  Volume: 390 Pages: 1247-1253
- DOI
  10.1007/s00210-017-1423-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08554, KAKENHI-PROJECT-15K07971, KAKENHI-PROJECT-15K08242
[Journal Article] Stimulation of μ-opioid receptors dilates retinal arterioles by neuronal nitric oxide synthase-derived nitric oxide in rats.2017
- Author(s)
  Someya E, Mori A, Sakamoto K, Ishii K, Nakahara T
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 803 Pages: 124-129
- DOI
  10.1016/j.ejphar.2017.03.043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460103, KAKENHI-PROJECT-16K08554, KAKENHI-PROJECT-15K07971, KAKENHI-PROJECT-15K08242
[Journal Article] Mechanisms underlying dysfunction of retinal blood vessels in diabetic rats2015
- Author(s)
  Mori A, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  Folia Pharmacol. Jpn.
  
  Volume: 145 Issue: 2 Pages: 70-73
- DOI
  10.1254/fpj.145.70
- NAID
  130004827720
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24790261
[Journal Article] Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina2015
- Author(s)
  Asano D, Nakahara T, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  J Neurosci Res
  
  Volume: 93 Pages: 380-390
- DOI
  10.1002/jnr.23492
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712
[Journal Article] Effect of Long-Term Treatment of L-Ornithine on Visual Function and Retinal Histology in the Rats2015
- Author(s)
  Sakamoto K, Mori A, Nakahara T, Morita M, Ishii K.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 38 Issue: 1 Pages: 139-143
- DOI
  10.1248/bpb.b14-00491
- NAID
  130004872232
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329
[Journal Article] 4-Hydroxy-2-nonenal attenuates β2-adrenoceptor-mediated vasodilation of rat retinal arterioles2015
- Author(s)
  Mori A, Takei T, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume: 388 Pages: 575-582
- DOI
  10.1007/s00210-015-1099-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PROJECT-24790261, KAKENHI-PUBLICLY-25122712
[Journal Article] Preventive Effects of Rapamycin on Inflammation and Capillary Degeneration in a Rat Model of NMDA-Induced Retinal Injury2015
- Author(s)
  Aoki Y, Nakahara T, Asano D, Ushikubo H, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 38 Issue: 2 Pages: 321-324
- DOI
  10.1248/bpb.b14-00631
- NAID
  130004872255
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PROJECT-26460103
[Journal Article] Impaired retinal vasodilator response to acetylcholine in a rat model of NMDA-induced retinal degeneration2015
- Author(s)
  Mori A, Hanada M, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 127 Pages: 211-216
- DOI
  10.1016/j.jphs.2014.12.014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PROJECT-24790261, KAKENHI-PUBLICLY-25122712
[Journal Article] P2X7 receptor antagonists protect against N-methyl-D-aspartic acid-induced neuronal injury in the rat retina.2015
- Author(s)
  Sakamoto K, Endo K, Suzuki T, Fujimura K, Kurauchi Y, Mori A, Nakahara T, Ishii K.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 756 Pages: 52-58
- DOI
  10.1016/j.ejphar.2015.03.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PROJECT-15K07971, KAKENHI-PROJECT-15K18865
[Journal Article] Age-dependent changes in the severity of capillary degeneration in rat retina following N-methyl-D-aspartate-induced neurotoxicity2015
- Author(s)
  Asami Y, Nakahara T, Asano D, Kurauchi Y, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  Curr Eye Res
  
  Volume: 30 Pages: 1-5
- DOI
  10.3109/02713683.2014.933851
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712
[Journal Article] Treatment of mid-pregnant mice with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces abnormal retinal vascular patterning in their newborn pups2014
- Author(s)
  Morita A, Nakahara T, Abe N, Kurauchi Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K.
- Journal Title
  
  Birth Defects Res B Dev Reprod Toxicol
  
  Volume: 101 Pages: 293-299
- DOI
  10.1002/bdrb.21112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712
[Journal Article] Effects of mTOR inhibition on normal retinal vascular development in the mouse2014
- Author(s)
  Yagasaki R, Nakahara T, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  Exp Eye Res
  
  Volume: 129 Pages: 127-134
- DOI
  10.1016/j.exer.2014.11.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712
[Journal Article] Activation of the TRPV1 channel attenuates N-methyl-D-aspartic acid-induced neuronal injury in the rat retina.2014
- Author(s)
  Sakamoto K, Kuroki T, Okuno Y, Sekiya H, Watanabe A, Sagawa T, Ito H, Mizuta A, Mori A, Nakahara T, Ishii K.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 733 Pages: 13-22
- DOI
  10.1016/j.ejphar.2014.03.035
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329
[Journal Article] Anti-angiogenic Effects of Mammalian Target of Rapamycin Inhibitors in a Mouse Model of Oxygen-Induced Retinopathy2014
- Author(s)
  Yagasaki R, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37 Issue: 11 Pages: 1838-1842
- DOI
  10.1248/bpb.b14-00487
- NAID
  130004703901
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712
[Journal Article] Rapamycin prevents N-methyl-D-aspartate-induced retinal damage through an ERK-dependent mechanism in rats.2014
- Author(s)
  Ichikawa A, Nakahara T, Kurauchi Y, Mori A, Sakamoto K, Ishii K
- Journal Title
  
  J Neurosci Res.
  
  Volume: 92(6) Pages: 692-702
- DOI
  10.1002/jnr.23358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590112, KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PROJECT-24890225
[Journal Article] Treatment of Newborn Mice with Inhibitors of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Induces Abnormal Retinal Vascular Patterning2014
- Author(s)
  Morita A, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37 Issue: 12 Pages: 1986-1989
- DOI
  10.1248/bpb.b14-00540
- NAID
  130004703916
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712, KAKENHI-PROJECT-26460103
[Journal Article] Noradrenaline contracts r at retinal arterioles via stimulation ofα(1A)-andα(1D)-adrenoceptors2011
- Author(s)
  Mori A, Hanada M, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 673 Pages: 65-69
- DOI
  10.1016/j.ejphar.2011.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102, KAKENHI-PROJECT-21790249
[Journal Article] Role of calcium-activated potassium channels in acetylcholine-induced vasodilation of rat retinal arterioles in vivo.2011
- Author(s)
  Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol.
  
  Volume: 383 Pages: 27-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] BMS-191011, an opener of large-conductance Ca^<2+>-activated potassium channels, dilates rat retinal arterioles in vivo.2011
- Author(s)
  Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 34 Pages: 150-152
- NAID
  130000402279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Role of calcium-activated potassium channels in acetylcholine-induced vasodilation of rat retinal arterioles in vivo2011
- Author(s)
  Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume: 383 Pages: 27-34
- URL
  http://dx.doi.org/10.1007/s00210-010-0570-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Role of ss_3-adrenoceptors in regulation of retinal vascular tone in rats2011
- Author(s)
  Mori A, Nakahara T, Sakamoto K, Ishii K
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume: 384 Pages: 603-608
- URL
  http://dx.doi.org/10.1007/s00210-011-0682-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Vasodilation of retinal arterioles induced by activation of BK_<Ca> channels is attenuated in diabetic rats2011
- Author(s)
  Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 669 Pages: 94-99
- URL
  http://dx.doi.org/10.1016/j.ejphar.2011.07.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Noradrenaline contracts rat retinal arterioles via stimulation ofα_<1A-> andα_<1D-> adrenoceptors2011
- Author(s)
  Mori A, Hanada M, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 673 Pages: 65-69
- URL
  http://dx.doi.org/10.1016/j.ejphar.2011.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] BMS-191011, an opener of large-conductance Ca^<2+>-activated potassium channels, dilates rat retinal arterioles in vivo2011
- Author(s)
  Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34 Pages: 150-152
- NAID
  130000402279
- URL
  http://dx.doi.org/10.1248/bpb.34.150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Role ofβ_3-adrenoceptors in regulation of retinal vascular tone in rats2011
- Author(s)
  Mori A, Nakahara T, Sakamoto K, Ishii K
- Journal Title
  
  Naunyn- Schmiedeberg's Arch Pharmacol
  
  Volume: 384 Pages: 603-608
- DOI
  10.1007/s00210-011-0682-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102, KAKENHI-PROJECT-21790249, KAKENHI-PROJECT-23590112
[Journal Article] Drugs for improving retinal circulation : current status and future perspectives.2010
- Author(s)
  Nakahara T, Mori A, Sakamoto K, Ishii K.
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 135 Pages: 146-148
- NAID
  10029416613
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Hyperglycemia impairs acetylcholine-induced vasodilation of retinal arterioles through polyol pathway-independent mechanisms in rats.2010
- Author(s)
  Mori A, Saigo O, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  J Pharmacol Sci. 112(3)
  
  Pages: 336-342
- NAID
  10027744548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Pharmacological evidence for the presence of functional ss_3-adrenoceptors in rat retinal blood vessels2010
- Author(s)
  Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume: 382 Pages: 119-126
- URL
  http://dx.doi.org/10.1007/s00210-010-0526-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Drugs for improving retinal circulation : current status and future perspectives2010
- Author(s)
  Nakahara T, Mori A, Sakamoto K, Ishii K
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 135(4) Pages: 146-148
- NAID
  10029416613
- URL
  http://dx.doi.org/10.1254/fpj.135.146
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Hyperglycemia impairs acetylcholine-induced vasodilation of retinal arterioles through polyol pathway-independent mechanisms in rats2010
- Author(s)
  Mori A, Saigo O, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 112 Pages: 336-342
- NAID
  10027744548
- URL
  http://dx.doi.org/10.1254/jphs.09312FP
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Pharmacological evidence for the presence of functional β_3-adrenoceptors in ratretinal blood vessels.2010
- Author(s)
  Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol.
  
  Volume: 382 Pages: 119-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590102
[Journal Article] Attenuation of nitric oxide- and prostaglandin-independent vasodilation of retinal arterioles induced by acetylcholine in streptozotocin-treated rats.2007
- Author(s)
  Nakazawa T, Kaneko Y, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Vascular Pharmacology 46(3)
  
  Pages: 153-159
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Establishment of a precise methods for evaluating rat cataract by using two types pf digital camera systems that are equipped with a non-reflecting illuminator or a slit lamp.2007
- Author(s)
  Ueo M, Saito M, Takenaka M, Saigo O, Nakatani H, Hayashi K, Nakahara T, Sakamoto K, Ishii K
- Journal Title
  
  Journal of Pharmacological Sciences 103 (Suppl. I)
  
  Pages: 270-270
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Stimulation of EP_2 receptor dilates retinal blood vessels and increses fundus blood flow in rats.2007
- Author(s)
  Mori A, Saito M, Sakamoto K, Narita M, Nakahara T, Ishii K
- Journal Title
  
  Journal of Pharmacological Sciences 103(Suppl. I)
  
  Pages: 248-248
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats.2007
- Author(s)
  Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Journal of Pharmacological Sciences 103(1)
  
  Pages: 103-112
- NAID
  10024312187
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats.2006
- Author(s)
  Kaneko Y, Saito M, Mori A, Sakamoto K, Nakahara T, Ishii K
- Journal Title
  
  Journal of Ocular Pharmacology 22(5)
  
  Pages: 317-322
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Cilnidipine reduces neuronal cell death induced by intravitreous injection of NMDA in the rat retina.2006
- Author(s)
  Kawakami T, Saito M, Nakahara T, Sakamoto K, Ishii K.
- Journal Title
  
  Journal of Pharmaceutical Sciences 100(suppl.I)
  
  Pages: 150-150
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Differential mechanisms of bradykinin-induced vasodilation in retinal and peripheral blood vessels of rats.2006
- Author(s)
  Kojima N, Saito M, Mori A, Nakahara T, Sakamoto K., Ishii K.
- Journal Title
  
  Journal of Pharmaceutical Sciences 100(suppl.I)
  
  Pages: 67-67
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Modulation of cell cycle reduces neuronal cell death observed after ischemia-reperfusion in the rat retina.2006
- Author(s)
  Ohki K, Saito M, Nakahara T, Sakamoto K, Ishii K.
- Journal Title
  
  Journal of Pharmaceutical Sciences 100(suppl.I)
  
  Pages: 259-259
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Disappearance of glibenclamide-induced hypoglycemia in wistar-kyoto rats.2006
- Author(s)
  Sakamoto K.他8名(9番目の著者:Ishii K.)
- Journal Title
  
  Biological and Pharmaceutical Bulletin 29(3)
  
  Pages: 574-576
- NAID
  110005602148
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retina.2006
- Author(s)
  Sakamoto K.他6名(7番目の著者:Ishii K.)
- Journal Title
  
  Experimental Eye Research 82(3)(In press)
- Data Source
  KAKENHI-PROJECT-17659048
[Journal Article] Involvement of the βγ subunits of G proteins in the cAMP response induced by stimulation of the histamine H_1 receptor.2005
- Author(s)
  Maruko T.他6名(7番目の著者:Ishii K.)
- Journal Title
  
  Naunyn-Schmiedebergs Archives of Pharmacology 372(2)
  
  Pages: 153-159
- Data Source
  KAKENHI-PROJECT-17659048
[Patent] 特許権2007
- Inventor(s)
  石井邦雄他
- Industrial Property Rights Holder
  北里学園
- Industrial Property Number
  2007-032923
- Filing Date
  2007-02-15
- Data Source
  KAKENHI-PROJECT-17659048
[Presentation] ラット網膜においてオピオイド μ 受容体刺激は神経由来の NO 産生を介して血管を拡張させる2017
- Author(s)
  染谷英理子，森　麻美，坂本謙司，石井邦雄，中原　努
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08554
[Presentation] Probucol ameliorates dydfunction of retinal circulation in diabetes rats.2014
- Author(s)
  Kentaro Higashi, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
- Organizer
  第 87 回日本薬理学会年会
- Place of Presentation
  宮城県仙台市（仙台国際センター）
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] NO は電位依存性カリウムチャネルを介してラット網膜血管を拡張させる2014
- Author(s)
  森麻美，滑川　諒，坂本謙司，中原努，石井邦雄
- Organizer
  日本薬学会第 134 年会
- Place of Presentation
  熊本県熊本市（熊本市総合体育館）
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] Mechanisms underlying dysfunction of retinal blood vessels in diabetes rats.2014
- Author(s)
  Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
- Organizer
  第 87 回日本薬理学会年会
- Place of Presentation
  宮城県仙台市（仙台国際センター）
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] ラット網膜血管における gap junction を介した拡張機序の解明2014
- Author(s)
  森　麻美，滑川　諒，坂本　謙司，中原　努，石井　邦雄
- Organizer
  第 130 回日本薬理学会関東部会
- Place of Presentation
  星薬科大学　百年記念館（東京都品川区）
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] NO による網膜血管拡張反応における PGI2 の役割2013
- Author(s)
  滑川　諒，森　麻美，坂本　謙司，中原　努，石井　邦雄
- Organizer
  第 128 回日本薬理学会関東部会
- Place of Presentation
  東京都新宿区（早稲田大学国際会議場）
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] L-Citrulline dilates retinal blood vessels in rats2012
- Author(s)
  Mori A, Takei T, Morita M, Nakagawa S, Sakamoto K, Nakahara T, Ishii K
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  (京都)日本薬理学会
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] L-Citrulline ameliorates dysfunction of retinal circulation in diabetic rats2012
- Author(s)
  Takei T, Mori A, Morita M, Nakagawa S, Sakamoto K, Nakahara T, Ishii K
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  (京都)日本薬理学会
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] NMDA誘発緑内障モデルにおける網膜血管反応性の変化2011
- Author(s)
  森麻美、花田真幸、坂本謙司、中原努、石井邦雄
- Organizer
  第124回日本薬理学会関東部会
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] Changes in responsiveness of the retinal blood vessels induced by intravitreal injection of NMDA in rats2011
- Author(s)
  Hanada M, Mori A, Sakamoto K, Nakahara T, Ishii K
- Organizer
  第84回日本薬理学会年会
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] EDHFはBKCaチャネルを介してラット網膜血管を拡張させる2011
- Author(s)
  森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2011
- Place of Presentation
  (東京)日本薬学会薬理系薬学部会
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] EDHFはBK_<Ca>チャネルを介してラット網膜血管を拡張させる2011
- Author(s)
  森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2011
- Place of Presentation
  東京
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] NMDA誘発緑内障モデルにおける網膜血管反応性の変化2011
- Author(s)
  森麻美, 花田真幸, 坂本謙司, 中原努, 石井邦雄
- Organizer
  第124回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 新規網膜血流量測定システムの構築とそれによる網膜循環改善薬の探索2011
- Author(s)
  森麻美、花田真幸、坂本謙司、中原努、石井邦雄
- Organizer
  第12回Pharmaco-Hematologyシンポジウム
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 新規網膜血流量測定システムの構築とそれによる網膜循環改善薬の探索2011
- Author(s)
  森麻美, 花田真幸, 坂本謙司, 中原努, 石井邦雄
- Organizer
  第12回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  富山
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 高血糖はポリオール経路非依存性機序を介してアセチルコリンによるラット網膜細動脈拡張を障害する2010
- Author(s)
  森麻美, 西郷織江, 坂本謙司, 中原努, 石井邦雄
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] ACh誘発EDHF様ラット網膜血管拡張反応におけるBKCaチャネルの役割2010
- Author(s)
  森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
- Organizer
  第20回日本循環薬理学会,第38回薬物活性シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] ACh誘発EDHF様ラット網膜血管拡張反応におけるBK_<ca>チャネルの役割2010
- Author(s)
  森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
- Organizer
  第20回日本循環薬理学会
- Place of Presentation
  札幌
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] Drugs for improving retinal circulation : Current status and future.2010
- Author(s)
  Ishii K, Mori A, Sakamoto Nakahara T.
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 高血糖はポリオール経路非依存性機序を介してアセチルコリンによるラット網膜細動脈拡張を障害する2010
- Author(s)
  森麻美, 西郷織江, 坂本謙司, 中原努, 石井邦雄
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  (岡山)日本薬学会
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] NO dilates retinal arterioles through the COX-1 derived prostanoids-cAMP signaling pathway in rats in vivo.2010
- Author(s)
  Mori A, Nakahara T, Hoshino M, Sakamoto K, Ishii K.
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] Drugs for improving retinal circulation : Current status and future2010
- Author(s)
  Ishii K, Mori A, Sakamoto K, Nakahara T
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  (大阪)日本薬理学会
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] NO dilates retinal arterioles through the COX-1 derived prostanoids-cAMP signaling pathway in rats in vivo2010
- Author(s)
  Mori A, Nakahara T, Hoshino M, Sakamoto K, Ishii K
- Organizer
  第83回日本薬理学会年会日本薬理学会
- Place of Presentation
  大阪
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] NO dilates rat retinal blood vessels through the COX-1-dependent prostanoids-cAMP signalling pathway in vivo2010
- Author(s)
  Kunio Ishii, A Mori, K Sakamoto, T Nakahara
- Organizer
  16th World Congress on Basic and Clinical Pharmacology World Pharma 2010
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] ACh誘発ラット網膜血管拡張反応におけるK_<ca> channelの関与2009
- Author(s)
  鈴木佐知, 森麻美, 中原努, 坂本謙司, 石井邦雄
- Organizer
  第120回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 糖尿病モデルラットを用いた糖尿病性眼合併症の発症・進行機序の解析:ポリオール経路の意義2009
- Author(s)
  石井邦雄、中原努、坂本謙司、森麻美
- Organizer
  第121回日本薬理学会関東部会日本薬理学会
- Place of Presentation
  東京
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 1型糖尿病モデルラットを用いた網膜循環障害発症機序の解析2009
- Author(s)
  石井邦雄
- Organizer
  日本薬学会関東支部第34回学術講演会日本薬学会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 1型糖尿病モデルラットを用いた網膜循環障害発症機序の解析2009
- Author(s)
  石井邦雄
- Organizer
  日本薬学会関東支部第34回学術講演会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] ACh誘発ラット網膜血管拡張反応におけるK_<Ca> channelの関与2009
- Author(s)
  鈴木佐知, 森麻美, 中原努, 坂本謙司, 石井邦雄
- Organizer
  第120回日本薬理学会関東部会日本薬理学会
- Place of Presentation
  東京
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 糖尿病モデルラットを用いた糖尿病性眼合併症の発症・進行機序の解析:ポリオール経路の意義2009
- Author(s)
  石井邦雄
- Organizer
  第121回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590102
[Presentation] 網膜循環調節機構の基礎的研究と糖尿病性眼疾患に対する新規予防治療戦略開拓の試み
- Author(s)
  石井　邦雄
- Organizer
  第 32 回日本眼薬理学会学術集会（招待講演）
- Place of Presentation
  滋賀県大津市（ピアザ淡海）
- Invited
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] 4-ヒドロキシ 2-ノネナールはアドレナリン β2 受容体刺激薬によるラット網膜細動脈拡張反応を減弱させる
- Author(s)
  森麻美, 武井俊明, 坂本謙司, 中原努, 石井邦雄
- Organizer
  第 88 回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] プロスタノイド EP2 受容体刺激薬の緑内障予防・治療薬としての可能性
- Author(s)
  森麻美，黒崎航平，牛久保裕子，坂本謙司，中原努，石井邦雄
- Organizer
  第 34 回日本眼薬理学会
- Place of Presentation
  長谷川国際会議場（岐阜県岐阜市）
- Year and Date
  2014-09-13 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] Role of beta3-adrenoceptors in the regulatory mechanism of retinal vascular tone in rats.
- Author(s)
  Mori A, Nakahara T, Kurauchi Y, Sakamoto K, Ishii K.
- Organizer
  第86 回日本薬理学会年会
- Place of Presentation
  福岡県福岡市（福岡国際会議場）
- Data Source
  KAKENHI-PROJECT-24590122
[Presentation] エルカトニンのラット網膜循環に及ぼす影響
- Author(s)
  森麻美，須澤弘典，坂本謙司，中原努，石井邦雄
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザインクリエイティブセンター神戸（兵庫県神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590122

1. NAKAYAMA Koichi (50112769)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. NAKAHARA Tsutomu (10296519)

# of Collaborated Projects: 6 results

# of Collaborated Products: 72 results
3. TASNAKA Yoshio (60188349)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. MORI Asami (80453504)

# of Collaborated Projects: 3 results

# of Collaborated Products: 64 results
5. TANABE Yoshiyuki (10275109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山本慧 (50138129)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OBARA Kazuo (60117611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKEISHI Keiichi (90012608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 斉藤麻希 (40365185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. 加藤隆一 (40112685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中木敏夫 (30164148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ASANO Toshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 浅井敏雄

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KURAUCHI Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 坂本謙司

# of Collaborated Projects: 0 results

# of Collaborated Products: 18 results

ISHI Kunio 石井 邦雄

ISHII Kunio 石井 邦雄

石井 邦雄 イシイ クニオ

Research Projects

Research Products

Co-Researchers

Mechanisms of neuronal-glial-vascular interactions in the retina and the development of novel strategies for treating retinal diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Elucidation of mechanisms for regulating retinal circulation and identification of target molecule for novel preventive and/or therapeutic drugs for retinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular basis attributed to onset of abnormal retinal hemodynamics and strategy of novel prevention drugs for retinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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動的光散乱法を中心とした糖尿病性白内障進展過程の解析と予防薬/治療薬開発への応用Principal Investigator

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Development of high-resolution digital fundus camera for small animals and application of it to studies on analysis of responsiveness of retinal blood vesselsPrincipal Investigator

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Studies on responsiveness of rat retial blood vessels with a newly developed digital funduscope system for small animalsPrincipal Investigator

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Studies on changes in the pancreatic B cell function during development and aging assessed by computer-aided fluorescent microscopyPrincipal Investigator

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Reguratory mechanism of hypotensive responses to muscarinic cholinergic stimulation through the adrenergic receptor system.Principal Investigator

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ISHI Kunio 石井邦雄

ISHII Kunio 石井邦雄

石井邦雄イシイクニオ