NAKAKI Toshio 中木敏夫

Researcher Number	30164148
Other IDs
External Links
Affiliation (Current)	2019: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2017: Teikyo University, 医学部, 教授 2005 – 2006: 帝京大学, 医学部, 教授 2000 – 2003: Medicine, Pharmacology, Professor, 医学部, 教授 1997 – 1998: 帝京大学, 医学部, 助教授 1997 – 1998: 帝京大学, 医学部・薬理学講座, 助教授 … More
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator General pharmacology / Psychiatric science
Keywords	Principal Investigator 一酸化窒素 / ノルエピネフリン / GTRAP3-18 / パーキンソン病 / NO / EAAC1 / EDRF / システイン / hydrogen peroxide / neurodegeneration … More Except Principal Investigator 細菌内毒素 / 一酸化窒素 / 脱感作 / COMT / ノルエピネフリン / 血管平滑筋細胞 / 細胞内遊離Ca^<2+> / Perfusion / インターフェロン / ラット / NC合成酵素 / 抗6-ニトロノルエピネフリン抗体 / 牛副腎髄質培養クロマフィン細胞 / inositol phosphate / ラット大動脈 / 腫瘍壊死因子 / Catecholamine release / 副腎髄質クロマフィン細胞 / nicotinic receptor / Anti 6-nitronorepinephrine antibody / サイクリックGMP / Ca^<++> mobilization / Adrenal chromaffin cells / N-メチルアルギニン / 培養日数 / 細胞内Ca^<2+>濃度 / ピュ-ロマイシン / Intracellular Ca^<2+> concentration / イノシトール三リン酸 / 細胞内カルシウム濃度 / 6-nitronorepinephrine / アクチノマイシンD / Norepinephrine / Desensitization / NO生成酵素 / 平滑筋細胞 / Microcarrier beads / イノシトール三隣酸 / デキサメサゾン / ニコチン受容体 / 潅流 / 内皮 / PC12 / mRNA / PC 12 / PC 12 cells / Nitric Oxide / メチルアルギニン / 副腎髄質細胞 / インターロイキン / 分泌 / TNF-α / ムスカリン受容体 / カテコラミン分泌 / IL-1β / 細胞内Ca^<++>動員 / chromaffin cells / マイクロキャリア-ビ-ズ / 血管内皮細胞 / 細胞内遊離【Ca^(2+)】濃度,【Ca^(2+)】取り込み,脱感作,C-キナーゼ,副腎髄質クロマフィン細胞. / 6-ニトロノルエピネフリン Less

micro RNA as the master key for protection of oxidative stressPrincipal Investigator
- Principal Investigator
  
  Nakaki Toshio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Teikyo University
A study on mice with hypoglycemia and high cognitive abilityPrincipal Investigator
- Principal Investigator
  
  Nakaki Toshio
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Teikyo University
A study on CNS oxidative stress-resistant mousePrincipal Investigator
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Teikyo University
Effect of an alpha-lb adrenoceptor antagonist on methamphetamine-induced neuronal toxicityPrincipal Investigator
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Teikyo University
Rotenone-Induced ParkinsonismPrincipal Investigator
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Teikyo University
Implications of nitrocathecholamines in Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Teikyo University
Regulation of Monoaminergic Neurons in the Brain through Both Nitiric Oxide and Superoxide Anion
- Principal Investigator
  
  SHINTANI Futoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Keio University
Research on a novel endogenous catecholamine, 6-nitronorepinephrinePrincipal Investigator
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Teikyo University
血管平滑筋の新しい増殖促進機構:壁内外圧力差Principal Investigator
- Principal Investigator
  
  中木敏夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
血管における内皮依存性NO生成酵素誘導の機構
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
血管平滑筋細胞における腫瘍壊死因子によるNO生成酵素誘導の特異性Principal Investigator
- Principal Investigator
  
  中木敏夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
内皮からの新しいNO遊離調節機構:血管壁内外圧力差Principal Investigator
- Principal Investigator
  
  中木敏夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
Lーアルギニンの血圧降下作用機序の解明Principal Investigator
- Principal Investigator
  
  中木敏夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
Development of antihypertensive drugs: L-arginine and its derivatives as a precursor of endothelium-derived relaxing factorPrincipal Investigator
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KEIO UNIVERSITY
血管収縮の内皮細胞依存性脱感作に関与する物質の解析Principal Investigator
- Principal Investigator
  
  中木敏夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
Simultaneous Monitoring of Intracellular Calcium Concentration and Catecholamine Release from Superfused PC 12 Cells and Adrenal Chromaffin Cells Cultured on Microcarrier Beads.
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
Menbrane phospholipase c activation and signal transduction in relation to change of receptor-linkage mechanism
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University
副腎クロマフィン細胞における受容体刺激に伴うカルシウムイオン流入の急速脱感作機構
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Keio University

All 2018 2017 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Rosenberg RN, Pascal JM, editor. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease2015
- Author(s)
  Aoyama K. and Nakaki T. Disorders of Glutathione Metabolism.
- Total Pages
  1424
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24590333
[Book] Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease2014
- Author(s)
  Aoyama K. and Nakaki, T.
- Total Pages
  1464
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24590333
[Journal Article] A simple and effective method for detecting precipitated proteins in MALDI-TOF MS.2018
- Author(s)
  Oshikane H, Watabe M, Nakaki T.
- Journal Title
  
  Anal Biochem.
  
  Volume: 546 Pages: 1-4
- DOI
  10.1016/j.ab.2018.01.020
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08244
[Journal Article] Facilitation of yeast-lethal membrane protein production by detoxifying with GFP tagging.2018
- Author(s)
  Oshikane H, Watabe M, Nakaki T.
- Journal Title
  
  Protein Expr Purif.
  
  Volume: 140 Pages: 40-45
- DOI
  10.1016/j.pep.2018.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08244
[Journal Article] Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs.2018
- Author(s)
  Kinoshita C, Aoyama K, Nakaki T.
- Journal Title
  
  FASEB J.
  
  Volume: 32 Pages: 330-341
- DOI
  10.1096/fj.201700421r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08244
[Journal Article] Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1).2015
- Author(s)
  Aoyama, K. Nakaki, T.
- Journal Title
  
  Molecules (Basel, Switzerland)
  
  Volume: 20 Pages: 8742-8758
- DOI
  10.3390/molecules20058742
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08244, KAKENHI-PROJECT-24590333
[Journal Article] microRNA as a new agent for regulating neuronal glutathione synthesis and metabolism2015
- Author(s)
  Kinoshita C, Aoyama K and Nakaki T
- Journal Title
  
  AIMS Molecular Science
  
  Volume: 2 Pages: 124-143
- DOI
  10.3934/molsci.2015.2.124
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590333
[Journal Article] Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels2014
- Author(s)
  Kinoshita, C. Aoyama, K. Matsumura, N. Kikuchi-Utsumi, K. Watabe, M. Nakaki, T.
- Journal Title
  
  Nature Comminucations
  
  Volume: 5:3823 Pages: 3823-3823
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590333
[Journal Article] Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1)2013
- Author(s)
  Aoyama K and Nakaki T
- Journal Title
  
  Amino Acids
  
  Volume: 45 Pages: 133-142
- DOI
  10.1007/s00726-013-1481-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500454, KAKENHI-PROJECT-24590333
[Journal Article] Impaired glutathione synthesis in neurodegeneration2013
- Author(s)
  Aoyama K and Nakaki T
- Journal Title
  
  Int J Mol Sci
  
  Volume: 14 Pages: 21021-21044
- DOI
  10.3390/ijms141021021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500454, KAKENHI-PROJECT-24590333
[Journal Article] Inhibition of GTRAP3-18 May Increase Neuroprotective Glutathione (GSH) Synthesis2012
- Author(s)
  Aoyama K and Nakaki T
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 13 Pages: 12017-12035
- DOI
  10.3390/ijms130912017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500454, KAKENHI-PROJECT-24590333
[Journal Article] Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice2012
- Author(s)
  Aoyama K, Wang F, Matsumura N, Kiyonari H, Shioi G, Tanaka K, Kinoshita C, Kikuchi-Utsumi K, Watabe M and Nakaki T
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Pages: 973-982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590291
[Journal Article] reased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mi2012
- Author(s)
  Aoyama K, Wang F, Matsumura N, Kiyonari H, Shioi G, Tanaka K, Kinoshita C, Kikuchi-Utsumi K, Watabe M, Nakaki T
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 45 Pages: 973-982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590291
[Journal Article] Caffeine and uric acid mediate glutathione synthesis for neuroprotection2011
- Author(s)
  Aoyama K, Matsumura N, Watabe M, Wang F, Kikuchi-Utsumi K, and Nakaki T
- Journal Title
  
  Neuroscience
  
  Volume: 181 Pages: 206-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590291
[Journal Article] Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAF2011
- Author(s)
  Aoyama K, Nakaki T
- Journal Title
  
  Amino Acids
  
  Volume: 3月5日号
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590291
[Journal Article] Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-182011
- Author(s)
  Aoyama K and Nakaki T
- Journal Title
  
  Amino Acids
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590291
[Journal Article] Caffeine and uric acid mediate glutathione synthesis for neuroprotection.2011
- Author(s)
  Aoyama K, Nakaki T
- Journal Title
  
  Neurosciense
  
  Volume: 181 Pages: 206-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590291
[Presentation] microRNA制御を受けるRNAタンパク質群によるGTRAP3-18の調節2017
- Author(s)
  木下千智、押鐘浩之、渡部正彦、内海　計、中木　敏夫
- Organizer
  第90回　日本薬理学会年会
- Place of Presentation
  長崎市、長崎ブリックホール
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K08244
[Presentation] 日内リズムを呈する miR-96-5p によるグルタチオン量調節と神経保護作用2015
- Author(s)
  木下千智青山晃治松村暢子内海計渡部正彦中木敏夫
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] AMPK活性化が神経グルタチオン産生に及ぼす影響2015
- Author(s)
  青山晃治角田ワッタナポン中木敏夫
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] 神経変性疾患に於けるタンパク質間相互作用（PPI)を基礎とした薬剤スクリーニング系の構築の試み2015
- Author(s)
  押鐘浩之, 有坂文雄, 渡部正彦, 青山晃治,中木敏夫
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2015-04-01
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] アイソボログラム解析が示す抗てんかん薬の作用機序依存的な併用効果2015
- Author(s)
  松村暢子中木敏夫
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] 酸化ストレス誘発性Parkinタンパク質活性化に及ぼすタンパク質リン酸化酵素CK2の影響2015
- Author(s)
  渡部正彦中木敏夫
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] メタンフェタミン投与ラットにおける線条体グルタミン酸およびシトルリンレベルに及ぼすα1Dアドレナリン受容体拮抗薬の影響2015
- Author(s)
  内海計松村暢子渡部正彦中木敏夫
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] 神経変性疾患に於けるタンパク質間相互作用（PPI)を基礎とした薬剤スクリーニング系の構築の試み2015
- Author(s)
  押鐘浩之有坂文雄渡部正彦青山晃治中木敏夫
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] GTRAP3-18欠損マウスにおける記憶学習能力の行動学的解析2013
- Author(s)
  青山晃治、中木敏夫　他
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590333
[Presentation] GTRAP3-18欠損マウスにおける神経グルタチオン増加と神経保護作用2012
- Author(s)
  青山晃治, 王凡, 松村暢子, 清成寛, 塩井剛, 田中かろ, 木下千智, 内海計, 渡部正彦, 中木敏夫
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590291
[Presentation] プリン誘導体による神経グルタチオン増加2012
- Author(s)
  青山晃治、松村暢子、渡部正彦、王凡、中木敏夫
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2012-03-22
- Data Source
  KAKENHI-PROJECT-21590291
[Presentation] プリン誘導体による神経グルタチオン増加2011
- Author(s)
  青山晃治、松村暢子、渡部正彦、王凡、中木敏夫
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜(誌上発表)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-21590291
[Presentation] Modulation of neuronal glutathione synthesis2011
- Author(s)
  Nakaki T
- Organizer
  11th National Sino-Western Joint Conference on Microcirculation
- Place of Presentation
  Yentai, China
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-21590291
[Presentation] マウスの摂食行動が海馬グルタチオン産生に及ぼす影響
- Author(s)
  青山晃治、角田ワッタナポン、押鐘浩之、中木敏夫
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24590333

1. KATO Ryuichi (40112685)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. SASAKAWA Nobuyuki (20187107)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MATSUMURA Nobuko (30317698)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. AOYAMA Koji (00420943)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
5. YAMAMOTO Satoshi (50138129)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SUZUKI Hiromichi (80129494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SARUTA Takao (70051571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHINTANI Futoshi (90276379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UTSUMI Kazue (90271759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 石井邦雄 (90137993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 押鐘浩之 (10727283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. SONAKA Ichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 日比清勝

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 真砂央

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAKI Toshio 中木 敏夫

Research Projects

Research Products

Co-Researchers

micro RNA as the master key for protection of oxidative stressPrincipal Investigator

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A study on mice with hypoglycemia and high cognitive abilityPrincipal Investigator

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A study on CNS oxidative stress-resistant mousePrincipal Investigator

Principal Investigator

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Effect of an alpha-lb adrenoceptor antagonist on methamphetamine-induced neuronal toxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

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Rotenone-Induced ParkinsonismPrincipal Investigator

Principal Investigator

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Implications of nitrocathecholamines in Parkinson's diseasePrincipal Investigator

Principal Investigator

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Research Institution

Regulation of Monoaminergic Neurons in the Brain through Both Nitiric Oxide and Superoxide Anion

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Research on a novel endogenous catecholamine, 6-nitronorepinephrinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管平滑筋の新しい増殖促進機構:壁内外圧力差Principal Investigator

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血管における内皮依存性NO生成酵素誘導の機構

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血管平滑筋細胞における腫瘍壊死因子によるNO生成酵素誘導の特異性Principal Investigator

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アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構

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内皮からの新しいNO遊離調節機構:血管壁内外圧力差Principal Investigator

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NAKAKI Toshio 中木敏夫