SARUTA Takao 猿田享男

Researcher Number	70051571
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Affiliation (based on the past Project Information) *help	1991 – 2004: 慶應義塾大学, 医学部, 教授 1998: Keio University School of Medicine, Dean, 医学部, 医学部長 1995 – 1997: 慶応大学, 医学部, 教授 1996: Keio University, School of Medicine, Associate Professor, 医学部, 教授 1992 – 1993: 慶応義塾大学, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator 内科学一般 / Biological Sciences / Kidney internal medicine / Endocrinology Except Principal Investigator General pharmacology / 内科学一般 / Laboratory animal science / 医学一般 / Laboratory medicine / Biomedical engineering/Biological material science / Circulatory organs internal medicine
Keywords	Principal Investigator 高血圧 / インスリン抵抗性 / hypertension / Pressure natriuresis curve / Intracellular calcium / Protein kinase C / Nitric oxide / Hypertension / SNP / COUP-TF … More Except Principal Investigator エンドセリン / バゾプレッシン / 一酸化窒素(NO) / メサンジウム細胞 / 国際学術集会 / 生物学 / 国際交流 / 高血圧 / EDRF / 本態性高血圧 / Ca-ATPase / 糸球体限外濾過 / 溶質輸送 / TGF機構 / 副甲状腺ホルモン / 心房性ナトリウム利尿ホルモン / メサンギウム細胞 / 血小板由来成長因子(PDGF) / TGFーβ / 細胞外基質 / 糸球体内皮細胞 / 熱ショック蛋白 / CNP / NO / アクチビンA / PD-ECGF / Rho / 胎児型ミオシン重鎖 / リゾフォスファチジルコリン / 血管内皮 / 血管平滑筋 / ナトリウム利尿ペプチドファミリー / エンドセリンファミリー / 血管内皮由来弛緩因子 / 低分子量G蛋白質 / リポ蛋白 / リポ蛋白リパーゼ / 自然発症ラット(SHR) / 脳卒中易発症ラット(SHRSP) / 正常血圧Wistar Kyoto rat / 自動調節機構 / 腎機能 / ホルモン / 体液 / 尿細管 / 情報伝達 / 水チャネル / レセプター / オ-トクリン / カルシウムイオン / 腎尿細管 / cAMP / 体液調節 / 腎 / 内分泌 / 利尿 / autoregulation / renal function / hormones / body fluid / mesangium cell / tubular cell / signal transduction / water channel / L-アルギニン / 抗高血圧薬 / 一酸化窒素 / 血漿cGMP / 亜硝酸塩、硝酸塩 / シトルリン / 内皮 / 本態性高血圧症 / 原発性アルドステロン症 / 腎血管性高血圧症 / L-arginine / Antihypertensive drug / Nitric oxide / Plasma cGMP / Nitrite / nitrate / Citrulline / Endothelium / 第3因子 / ジギタリス様物質 / Na,K-ATPase / essential hypertention / the third factor / digitalis-like substance / Na^+, K^+-ATPase / 卒後臨床研修 / 到達目標 / 研修実施体制 / 評価体制 / 研修プログラム / 大学附属病院 / Postgraduate clinical training / Objectives to be achieved / Training systems / Evaluation systems / Training programs / University hospital / 心内膜側細動脈 / 冠動脈slosh現象 / 高速度CCD生体顕微鏡 / niobium microsphere / 血管拍動性 / 高血圧肥大心 / 冠予備 / 心内膜側冠細動脈 / 心筋虚血 / 内皮依存性血管拡張反応 / 内皮非依存性血管拡張反応 / ACE阻害剤 / Subendocardial Arterioles / Coronary Slosh Phenomenon / High-speed CCD Intravital microscope / Niobium microsphere / Vascular Pulsation / カルシウム / ミオシン軽鎖 / Cキナ-ゼ / イノシト-ルリン酸 / 血管反応性 / キナ-ゼII / Ca ATPase / プロスタサイクリン / ナトリウム / 高血圧自然発症ラット / Ca / Mg / ミオンシン軽鎖 / Cキナーゼ / イノシトールリン脂質 / Ca-ATPaseブラジキニン / プロスタグランディン / 血清由来成長因子 / ビタミンD / 本熊性高血圧 / カルモデュリン / Hypertension / Calcium / Myosin light chain / Protein kinase C / Inositol phosphate / Endothelin / Vascular responsiveness Less

Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese menPrincipal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Department of Internal Medicine, Keio University School of Medicine
INVESTIGATION OF MECHANISM OF PREVENTION OF ATHEROSCLEROSIS BY SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERM)Principal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  KEIO UNIVERSITY
若年性遺伝性高血圧におけるインスリン抵抗性関連遺伝子の追究-不死化リンパ芽球を用いた細胞レベルのインスリン抵抗性-Principal Investigator
- Principal Investigator
  
  猿田享男
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
第5回「NOの生物学」国際学術集会の研究内容に関する企画
- Principal Investigator
  
  戸田昇
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Study of constitution of postgraduate clinical training programs in the university hospital
- Principal Investigator
  
  ISONO Kaichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Institution
  Chiba University
Clinical Relevance of Novel Angiotensin II Generation Pathway within the KidneyPrincipal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Evaluation of time sequential changes in subendocardial arteioles in the hypertensive hypertrophic canine heart by using needle-lens CCD intravital microscope
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
第5回「NOの生物学」国際学術集会の研究内容に関する企画
- Principal Investigator
  
  戸田昇
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Shiga University of Medical Science
Genetic Background and Underlying Mechanism in the Development of Postmenopausal HypertensionPrincipal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Keio University
Structural analysis of digitalis-like substance for the promoter of essential hypertention
- Principal Investigator
  
  ITOH Hajime
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kitasato University School of Allied Health Sciences
高血圧・脳卒中モデルとその対照系統の遺伝的標準化に関する研究
- Principal Investigator
  
  家森幸男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
血管機能における神経・体液性因子の相関・病態
- Principal Investigator
  
  北徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
腎臓の構造と機能の分子生物学的解析
- Principal Investigator
  
  黒川清
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Studies on protection of progression of renal impairment.Principal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Keio University
Development of antihypertensive drugs: L-arginine and its derivatives as a precursor of endothelium-derived relaxing factor
- Principal Investigator
  
  NAKAKI Toshio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KEIO UNIVERSITY
腎における限外濾過と溶質輸送に関する基礎的・臨床的研究
- Principal Investigator
  
  KUROKAWA K
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Study on Autoregulatory Mechanism of Body Fluid with Special Emphasis on Kidney and Hormones
- Principal Investigator
  
  MARUMO Fumiaki
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  医学一般
- Research Institution
  Tokyo Medical and Dental University
Roles of Vartous Natriuretic Factors in Essential HypertensivesPrincipal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Keio University
The Roles of Calcium in the Pathogenesis of Hypertension.
- Principal Investigator
  
  MASUYAMA Yoshiaki
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Wakayama Medical University
STUDIES ON THE INCIDENCE AND MECHANISM OF HYPERTENSION IN HEMI-NEPHRECTOMIZED SUBJECTS.Principal Investigator
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The Keio University

All 2005 2001 2000

All Journal Article

[Journal Article] Quantitative Trait Loci Mapping for intracellular Ca2+ in Spontaneously Hypertensive Rats.2005
- Author(s)
  Y Ohno, T Morii, T Saruta et al.
- Journal Title
  
  American Journal of Hypertension (In press)
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese men2005
- Author(s)
  T Morii, Y Ohno, T Saruta et al.
- Journal Title
  
  Metabolism Volume54,Issue 3
  
  Pages: 370-375
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Quantitative Trait Loci Mapping for intracellular Ca2+ in Spontaneously Hypertensive Rats.2005
- Author(s)
  Y Ohno, T Morii, T Saruta et al.
- Journal Title
  
  American Journal of Hypertension 18
  
  Pages: 666-671
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese men2005
- Author(s)
  T Morii, Y Ohno, T Saruta et al.
- Journal Title
  
  Metabolism 54-3
  
  Pages: 370-375
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Correlation of sodium-related factors with insulin sensitivity in young, lean, male offspring of hypertensive and normotensive subjects.2001
- Author(s)
  Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Saruta T.
- Journal Title
  
  J Hum Hypertens. 15
  
  Pages: 393-399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Correlation of sodium-related factors with insulin sensitivity in young, lean, male offspring of hypertensive and normotensive subjects.2001
- Author(s)
  Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Saruta T
- Journal Title
  
  J Hum Hypertens. 15
  
  Pages: 393-399
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in rats.2000
- Author(s)
  Ohno Y, Tanase H, Nabika T, Morii T, Yamori Y, Saruta T.
- Journal Title
  
  Genetics 155(2)
  
  Pages: 785-792
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in rats.2000
- Author(s)
  Ohno Y, Tanase H, Nabika T, Morii T, Yamori Y, Saruta T
- Journal Title
  
  Genetics 155(2)
  
  Pages: 785-792
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Insulin sensitivity and calcium homeostasis in young, lean, normotensive male subjects.2000
- Author(s)
  Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Saruta T.
- Journal Title
  
  Hypertens Res. 23(5)
  
  Pages: 433-440
- NAID
  130003456455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204076
[Journal Article] Insulin sensitivity and calcium homeostasis in young, lean, normotensive male subjects.2000
- Author(s)
  Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Saruta T
- Journal Title
  
  Hypertens Res. 23(5)
  
  Pages: 433-440
- NAID
  130003456455
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204076

1. HAYASHI Koichi (80164937)

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2. KUROKAWA K (30167390)

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3. HAYASHI Matsuhiko (60129608)

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4. SUZUKI Hiromichi (80129494)

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5. MARUMO Fumiaki (00050443)

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6. IMAI M (40049010)

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7. 井村裕夫 (10025570)

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14. SAITO T (10048994)

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15. ORITA Y (70028398)

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16. ENDO H (20101115)

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17. NAKAMOTO Hidetomo (90180421)

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18. NAKAKI Toshio (30164148)

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19. SASAKI Takayuki (40235255)

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20. HAYASHIDA Tomoko (20228604)

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21. OHNO Yoichi (10203895)

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22. ITOH Hajime (10104564)

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23. OGAWA Zensuke (50152385)

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24. ISONO Kaichi (70009489)

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31. MATSUDA Hiroto (80245498)

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32. KAJIYA Fumihiko (70029114)

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37. MORII Toshiyuki (60348654)

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38. KURIHARA Isao (90338038)

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39. SHIBATA Hirotaka (20245484)

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40. MASUYAMA Yoshiaki (30089164)

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41. IMAI Shoichi (60013869)

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67. SONAKA Ichiro

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SARUTA Takao 猿田 享男

Research Projects

Research Products

Co-Researchers

Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese menPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

INVESTIGATION OF MECHANISM OF PREVENTION OF ATHEROSCLEROSIS BY SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERM)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

若年性遺伝性高血圧におけるインスリン抵抗性関連遺伝子の追究-不死化リンパ芽球を用いた細胞レベルのインスリン抵抗性-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

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Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Clinical Relevance of Novel Angiotensin II Generation Pathway within the KidneyPrincipal Investigator

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Principal Investigator

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Genetic Background and Underlying Mechanism in the Development of Postmenopausal HypertensionPrincipal Investigator

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Principal Investigator

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Studies on protection of progression of renal impairment.Principal Investigator

Principal Investigator

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Principal Investigator

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SARUTA Takao 猿田享男