OGIHARA Toshio 荻原俊男

… Alternative Names

萩原俊男ハギワラトシオ

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Researcher Number	60107042
Other IDs
External Links
Affiliation (Current)	2025: 大阪大学, その他部局等, 名誉教授 2025: 森ノ宮医療大学, 保健医療学研究科, 教授
Affiliation (based on the past Project Information) *help	2016: 大阪大学, 医学系研究科, 名誉教授 2013 – 2015: 森ノ宮医療大学, 保健医療学部, その他 2013: 大阪大学, 医学系研究科, 名誉教授 2008: 大阪大学, 大学院・医学系研究科, 名誉教授 2007 – 2008: 大阪大学, 医学系研究科, 名誉教授 … More 2007: Osaka University, Professor Emeritus 1999 – 2006: 大阪大学, 医学系研究科, 教授 1988 – 1998: 大阪大学, 医学部, 教授 1987: Osaka University Medical School, 医学部, 助教授 1986: 阪大, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Biological Sciences / 内分泌・代謝学 / Applied health science / Kidney internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / General internal medicine(including psychosomatic medicine) / Experimental pathology / 内分泌・代謝学 / General internal medicine (including Psychosomatic medicine) / General medical chemistry / Laboratory animal science
Keywords	Principal Investigator 高血圧 / SNPs / hypertension / 疾患感受性 / 遺伝子多型 / NFkB / 遺伝子治療 / レニンーアンジオテンシン系 / TaqMan / デコイ … More / 薬剤反応性 / レニン-アンジオテンシン系 / HGF / gene therapy / 対立遺伝子 / E2F / 遺伝子導入 / obesity / salt sensitivity / gene environmental interaction / cardiovascular disease / disease susceptibility / gene polymorphism / 環境・遺伝相互作用 / テーラーメイド医療 / 食塩感受性 / 循環器疾患 / 遺伝疫学 / restenosis / ベクター / アンチセンス / 閉塞性動脈硬化症 / 再狭窄 / gene analysis / gene / 遺伝子解析 / 遺伝子 / 内因性ジギタリス様物質 / 本態性高血圧症 / HVJ-liposome法 / プローブ / がん / Potassium / Catacholamines / renin-angiotensin system Prostaglandins / Vasoactive hormone / Sodium chloride / Essental Hypertension / ビタミンD3 / PTH / Na-KATPaseインヒビター / 心房性ナトリウム利尿ペプチド / カテコラミン / アルドステロン / レニン / ナトリウム / 本態性高血圧 / カルシウム / カリウム / プロスタグランデイン, カテコラミン / 血圧調節ホルモン / 食塩 / 本能性高血圧 / tailored medicine / 候補遺伝子 / 肥満 / 遺伝・環境相互作用 / personalized medicine / 環境・遺伝子相互作用 / ゲノムスキャン / 環境因子 / genetic susceptibility / lacunar infarction / cohort study / renin-angiotensin system / pharamacogenetics / polymorphism / 疾患感受性遺伝子 / 地域住民検診 / アンジオテンシン変換酵素 / 遺伝的異質性 / 老年者 / レニンーアンジオテンシン系 / ラクナ梗塞 / コホート研究 / decoy oligonucleotides / atherosclerosis / vector / HVJ-liposome method / Gene therapy / 心筋梗塞 / 血管新生 / 動脈硬化 / peripheral arterial disease / decoy / vascular remodeling / アンジオテンシノジェン / レニン・アンジオテンシン系 / hepertension / angiotensinogen / GENE ANALYSIS / MOLECULAR BIOLOGY / GENE THERAPY / GENE DIAGNOSIS / MOLECULAR GENETICS / GENE / HYPERTENSION / フォスフォリパーゼ / 多因子疾患 / 高血圧自然発症ラット / 高血圧症 / 分離生理学 / 成因 / 分子生物学 / 遺伝子診断 / 分子遺伝学 / Na^+, K^+-ATPase / Prostaglandin derivative / Anti-ouabain antibody / Natriuretic factor / Essential hypertension / 立体特異性 / 抗ウワバインモノクロナル抗体 / ウワバイン様免疫活性 / 抗ウアドインモノクロナル抗体 / ウアバイン様免疫活性 / 内因性ジキタリス様物質 / Na^++K^+ーATPase / プロスタグランディン誘導体 / 抗ウアバインモノクロナル抗体 / ナトリウム利尿因子 / 国際情報交換 / 社会体育 / 高等学校 / 中学校 / 保健体育教育 / 医療系大学・学部 / 国際研究者交流　米・中・韓国 / 韓国の大学 / アメリカの大学 / 中国の大学 / 教員養成制度 / 教員養成大学・学部 / 現職教員 / カリキュラム / 教育実習 / 教員教育大学院 / 教員養成大学 / 高等学校教員 / 中学校教員 / 教員養成教育 / 医療系大学 / 保健体育科教員 / 保健体育科 / 教員養成 / 教員 / 分子治療 / HVJ-envelope法 / 核酸医薬 / 食塩感受性高血圧モデルラット / NKCC2遺伝子 / TSC遺伝子 / ASO / マイクロアレイ / 悪えき質 / 転写因子 / 転移 / サイトカイン / 悪疫質 / プロテオグリカン合成 / 細胞増殖 / エンドセリン1 / インタ-ロイキン2 / 細胞間相互作用 / Tリンパ球 / 血管平滑筋細胞 / 血管内皮細胞 … More Except Principal Investigator Klotho / 高血圧 / ACE2 / NO / SOD / hypertension / 遺伝子多型 / アンジオテンシンII / 遺伝子解析 / 軟骨細胞 / レニンーアンジオテンシン系 / 老化 / 血管内皮細胞 / 分子遺伝学 / 連鎖分析 / リバ-スジェネティクス / 家族性アルツハイマ-病 / アンジョテンシン受容体拮抗薬 / アンジオテンシン受容体拮抗薬 / 軟骨代謝 / アポトーシス / 軟骨変性 / 軟骨細胞代謝 / 変形性関節症 / アンジオテンシン受容体拮抗剤 / endothelial cells / 3T3-L1 cells / adhesion molecle / adipocyte differentiation / siRNA / klotho / 3T3-L1 / 接着因子 / 脂肪分化 / heart failure death / local RA system / MAP kinase / AT1 receptor / survival ratio / heart failure / knockout mice / 収縮障害 / AT1受容体拮抗薬 / JNK / ERK / 予後曲線 / TAC / 心不全死 / 局所RA系 / MAP Kinase / AT1受容体 / 死亡率 / 心不全 / ノックアウトマウス / blood pressure / oxidative stress / 血管 / cAMP / 内皮細胞 / 一酸化窒素 / MnSOD / 血管老化 / PKC / Ca代謝 / ビタミンD / 血圧 / 酸化ストレス / tailor-made medicine / renin-angiotensin system / gene-environmental interaction / genetic epidemiology / genetic dissection / アンジオテンシノージェン遺伝子 / 遺伝子 / レニン-アンジオテンシン系 / 遺伝子-環境相互作用 / テーラーメイド医療 / レニン・アンジオテンシン系 / 遺伝-環境相互作用 / 遺伝疫学 / vascular endothelial function / pulse wave velocity / gene polymorphism / atherosclerosis / 脳波速度 / 血管内皮機能 / 脈波速度 / 動脈硬化 / macrophages / immunocytochemistry / ischemic heart disease / chymase / angiotensin / angiotensin-converting / マクロファージ / 免疫組織化学 / 虚血性心疾患 / キマ-ゼ / アンジオテンシン変換酵素 / gene mapping / animal model / genetic analysis / diabetes / hypertinsion / SSLP marker / microsatellite marker / rat / 遺伝解析 / 遺伝子マッピング / 疾患モデル / 糖尿病 / SSLPマーカー / マイクロサテライトマーカー / ラット / 細胞内カルシウム / DIC / 血小板凝集阻止因子 / PAF / 血管内凝固症候群 / 食塩 / 本態性高血圧症 / 血中PAF濃度 / 質量分析 / 血中PAF微量測定法 / 血小板活性化因子 / 老年医学 / 骨折修復 / 骨芽細胞 / ARB / RA系 / アンジオテンシンII受容体拮抗薬 / 骨リモデリング / 骨粗鬆症 / テロメラーゼ / テロメア / hTERT / 正常血圧Wistar Kyoto rat / 脳卒中易発症ラット(SHRSP) / 自然発症ラット(SHR) / 遺伝的 / ヒト染色体 Less

Angiotensin II Modulates Hypertrophic Differentiation and Apoptosis of Chondrocytes: Relationship of hypertension to Osteoarthrosis
- Principal Investigator
  
  Aoki Motokuni
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Morinomiya University of Medical Sciences
A comprehensive study on teacher training in medical and health science universities:Principal Investigator
- Principal Investigator
  
  ogihara toshio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Morinomiya University of Medical Sciences
Role of RAS in bone remodeling and protective effect of ARB on bone density
- Principal Investigator
  
  AOKI Motokuni
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Morinomiya University of Medical Sciences
The establishment of telomerase control technology and applicationfor medical regeneration
- Principal Investigator
  
  ISHIKAWA Kazuhiko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
The protective effect of Klotho protein from vascular senescence adipocyte differentiation and endothelial function
- Principal Investigator
  
  RAKUGI Hiromi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Naチャンネル制御遺伝子導入システムによる高血圧症に対する革新的分子治療法の開発Principal Investigator
- Principal Investigator
  
  荻原俊男
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Osaka University
Establishment of a new treatment target for ischemia-related heart failure and arrhythmia-related sudden death
- Principal Investigator
  
  OHISHI Mitsuru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Functional analysis of senescence related Klotho gene and its application for the therapy
- Principal Investigator
  
  RAKUGI Hiromi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Osaka University
Identification of the susceptible gene responsible for essential hypertension and establishment of tailored medicinePrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Gene-Enviromental Interaction of Hypertension
- Principal Investigator
  
  HIGAKI Jitsuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Ehime University
Identification of genetic factors responsible for the pathogenesis of essential hypertensionPrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  OSAKA UNIVERSITY
Cell biological study on the genetic contribution in human atherosclerosis
- Principal Investigator
  
  RAKUGI Hiromi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OSAKA UNIVERSITY
本態性高血圧症の発症、進展に関与する遺伝因子の解明Principal Investigator
- Principal Investigator
  
  荻原俊男
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
多因子遺伝子性循環器疾患の遺伝子解析へのDNAチップ技術の応用Principal Investigator
- Principal Investigator
  
  荻原俊男
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
転写因子NFkBをターゲットとしたおとり型核酸医療薬を用いたがん遺伝子治療の開発Principal Investigator
- Principal Investigator
  
  荻原俊男
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Identification of genetic susceptibility for cardiovascular disease : two large genetic epidemiological study with cohort basePrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OSAKA UNIVERSITY
Gene Therapy in the Cardiovascular DiseasePrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Gene therapy for cardiovascular diseases : Development of newvector and evaluation of clinical strategyPrincipal Investigator
- Principal Investigator
  
  TOSHIO Ogihara
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OSAKA University
抗原利用型遺伝子導入法の開発とおとり型核酸医薬を用いたがん遺伝子治療に関する研究Principal Investigator
- Principal Investigator
  
  荻原俊男
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Role of vascular angiotensin-generating system in atherosclerosis and acute coronary syndrome : Specifoc role of macrophages and smooth muscle cells
- Principal Investigator
  
  RAKUGI Hiromi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Gene analysis of hypertension and development of new therapyPrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of SSLP markers in rat models for diabetes and hypertension.
- Principal Investigator
  
  SERIKAWA Tadao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
高血圧・脳卒中モデルとその対照系統の遺伝的標準化に関する研究
- Principal Investigator
  
  家森幸男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
Molecular Research of the Etiology and Treatment of HypertensionPrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
エンドセリンの動脈硬化発症および進展に果たす病態生理的役割の解明(特に血球系細胞ー血管内皮ー血管平滑筋相互作用の観点から)Principal Investigator
- Principal Investigator
  
  荻原俊男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
アルツハイマ-病家系の分子遺伝学的研究
- Principal Investigator
  
  三木哲郎
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
アルツハイマ-病家系の分子遺伝学的研究
- Principal Investigator
  
  MIKI Tetsuro
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ヒト内因性血小板凝集阻止因子の構造解明と梗塞性循環器疾患の病態に関する研究
- Principal Investigator
  
  MASUGI Fuminori (真枝文紀)
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
EndogenousPrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Pathogenesis of hypertension and interraction of vasoactive hormonesPrincipal Investigator
- Principal Investigator
  
  OGIHARA Toshio
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University

All 2015 2013 2012 2007 2006 2005 2004 2003 2002

All Journal Article Presentation Book Patent

[Book] 高血圧の遺伝子治療と再生医学2005
- Author(s)
  青木元邦, 荻原俊男
- Publisher
  日医雑誌
- Data Source
  KAKENHI-PROJECT-16659224
[Journal Article] Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse2015
- Author(s)
  Kawahata H, Sotobayashi D, Aoki M, Shimizu H, Nakagami H, Ogihara T, Morishita R.
- Journal Title
  
  Hypertension Research
  
  Volume: 38(6) Issue: 6 Pages: 382-393
- DOI
  10.1038/hr.2015.18
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460928
[Journal Article] Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse.2015
- Author(s)
  Kawahata H, Sotobayashi D, Aoki M, Shimizu H, Nakagami H, Ogihara T, Morishita R.
- Journal Title
  
  Ｈｙｐｅｒｔｅｎｓｉｏｎ　Ｒｅｓｅａｒｃｈ
  
  Volume: 19
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460928
[Journal Article] Klotho gene delivery suppresses oxidative stress in vivo2007
- Author(s)
  Ohta J, Rakugi H, Ishikawa K, Ogihara T et.al.
- Journal Title
  
  Geriatrics & Gerontology International 7(3)
  
  Pages: 293-299
- NAID
  10020021335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590265
[Journal Article] Anti-oxidative effect of Klotho on endothelial cells through cAMP activation2007
- Author(s)
  H Rakugi, Ishikawa K, Ogihara T et.al.
- Journal Title
  
  Endocrine 31(1)
  
  Pages: 82-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590265
[Journal Article] Klotho protein promotes adipocyte differentiation2006
- Author(s)
  Chihara Y, Rakugi H, Ishikawa K, Ogihara T et.al.
- Journal Title
  
  Endocrinology 147(8)
  
  Pages: 3835-3842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590265
[Journal Article] Deletion of ACE2 accelerates pressure-overload-induced cardiac dysfunction by increasing local angiotensin II2006
- Author(s)
  Yamamoto K, Ohishi M, Katsuya T, Ito N, Ikushima M, Kaibe M, Tatara Y, Shiota A, Sugano S, Takeda S, Rakugi H, Ogihara T.
- Journal Title
  
  Hypertension 47
  
  Pages: 718-726
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Deletion of ACE2 accelerates pressure-overload-induced cardiac dysfunction by increasing local angiotensin II2006
- Author(s)
  Yamamoto K, Ohishi M, Katsuya T, Rakugi H, Ogihara T, et al.
- Journal Title
  
  Hypertension 47
  
  Pages: 718-726
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells2006
- Author(s)
  Ikushima M, Rakugi H, Ishikawa K, Ogihara T et.al.
- Journal Title
  
  Biochem Biophys Res Commun 339(3)
  
  Pages: 827-832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590265
[Journal Article] Serum interleukin 15 concentration in patients with essential hypertension.2005
- Author(s)
  Kaibe M, Ohishi M, Ito N, Yuan M, Takagi T, Terai M, Tatara Y, Komai N, Rakugi H, Ogihara T.
- Journal Title
  
  Am J Hypertens 18
  
  Pages: 1019-1025
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Association of Hypoadiponectinemia With Smoking Habit in Men.2005
- Author(s)
  Iwashima Y, Katusya T, Ishikawa K, Kida I, Ohishi M, Horio T, Ouchi N, Ohashi K, Kihara S, Funahashi T, Rakugi H, Ogihara T.
- Journal Title
  
  Hypertension 45
  
  Pages: 1094-1100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Beta2-and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years.2005
- Author(s)
  Masuo A, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Circulation 111
  
  Pages: 3429-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years2005
- Author(s)
  Masuo K, Katsuya T, Fu Y, Rakugi H, Ogihara T, Tuck ML
- Journal Title
  
  Circulation 111
  
  Pages: 3429-3434
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] G2736A polymorphism of thiazide-sensitive Na-C1 cotransporter gene predisposes to hypertension in young women.2004
- Author(s)
  Masuo K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease.2004
- Author(s)
  Ohashi K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Am Coll Cardiol 43
  
  Pages: 1195-1200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Association between Angiotensin II Type 1 Receptor Gene Polymorphism and Essential Hypertension : the Ohasama Study.2004
- Author(s)
  Sugimoto K, Katsuva T, Ogihara T. et al.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 551-556
- NAID
  10013604128
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease.2004
- Author(s)
  Ohashi K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Am Coll Cardiol. 43
  
  Pages: 1195-1200
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Hypoadiponectinemia is an Independent Risk Factor for Hypertension2004
- Author(s)
  Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T.
- Journal Title
  
  Hypertension 43
  
  Pages: 1318-1323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy.2004
- Author(s)
  Fu Y, Katsuya T, Matsuo A, Yamamoto K, Akasaka H, Takami Y, Iwashima Y, Sugimoto K, Ishikawa K, Ohishi M, Rakugi H, Ogihara T.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 933-938
- NAID
  10014466755
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension2004
- Author(s)
  Iwashima Y, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertension 43
  
  Pages: 1318-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene Predisposes to hypertension in young women.2004
- Author(s)
  Matsuo A, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-2127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] A common polymorphism of uncoupling protein 2 gene is associated with hypertension.2004
- Author(s)
  Ji Q, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 97-102
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Association between hepatocyte growth factor gene polymorphism and essential hypertension.2004
- Author(s)
  Motone M, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertens Res. 27
  
  Pages: 247-251
- NAID
  10012925825
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension : the Ohasama Study.2004
- Author(s)
  Sugimoto K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertens Res. 27
  
  Pages: 551-556
- NAID
  10013604128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] A common polymorphism of uncoupling protein 2gene is associated with hypertension independent of obesity.2004
- Author(s)
  Ji Q, Ikegami H, Ohishi M, Ogihara et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 97-102
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.2004
- Author(s)
  Matsuo A, Katsuya T, Ishikawa K, Sugimoto K, Iwashima Y, Yamamoto K, Ohishi M, Rakugi H, Ogihara T
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-2127
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Association between Angiotensin II Type 1 Receptor Gene Polymorphism and Essential Hypertension : the Ohasama Study.2004
- Author(s)
  Sugimoto K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 551-556
- NAID
  10013604128
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Adiponectin I1647 mutation is associated with the metabolic syndrome and coronary artery disease.2004
- Author(s)
  Ohashi K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Am Coll Cardiol. 43
  
  Pages: 1195-2000
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population.2004
- Author(s)
  Takiuchi S, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Atherosclerosis 173
  
  Pages: 301-307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] A common polymorphism of uncoupling protein 2gene is associated with hypertension independent of obesity.2004
- Author(s)
  Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, Ohishi M, Katsuya T, Rakugi H, Ogihara T.
- Journal Title
  
  J Hypertens 22
  
  Pages: 97-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Association between hepatocyte growth factor gene polymorphism and essential hypertension.2004
- Author(s)
  Motone M, Katsuya T, Ishikawa K, Iwashima Y, Sugimoto K, Yamamoto K, Fu Y, Matsuo A, Ohishi M, Rakugi H, Ogihara T.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 247-252
- NAID
  10012925825
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.2004
- Author(s)
  Masuo A, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-2127
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Association between hepatocyte growth factor gene polymorphism and essential hypertension.2004
- Author(s)
  Motone M, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 247-251
- NAID
  10012925825
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Effect of nefedipine on endothelial function in normotensive smokers : potential contribution of increase in circulating hepatocyte growth factor.2004
- Author(s)
  Yamasaki K, Aoki M, Makino H, Hashiya N, Shimizu H, Ohishi M, Ogihara T, Morishita R.
- Journal Title
  
  J Hum Hypertens 18
  
  Pages: 701-705
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Green coffee beans extract improves human vasoreactivity2004
- Author(s)
  Ochiai R, Jyokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, Rakugi H, Ogihara T.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 731-737
- NAID
  10014224398
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.2004
- Author(s)
  Masuo A, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-2127
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension.2004
- Author(s)
  Iwashima Y, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertension 43
  
  Pages: 1318-1323
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] A common polymorphism of uncoupling protein 2 gene is associated with hypertension.2004
- Author(s)
  Ji Q, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 97-102
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] G2736A polymorphism of thiiazide-sensitive Na-CL cotransporter gene predisnoses to hypertension in young women.2004
- Author(s)
  Matsuo A, Katsuya T, Ishikawa K, Sugimoto K, Iwashima Y, Yamamoto K, Ohishi M, Rakugi H, Ogihara T.
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-2127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Insulin-mediated regulation of the endothelial renin-angiotensin system and vascular cell growth.2004
- Author(s)
  Kamide K, Rakugi H, Higaki J, Ogihara T, Tuck M, et al.
- Journal Title
  
  Journal of Hypertension 22
  
  Pages: 121-127
- Data Source
  KAKENHI-PROJECT-14370226
[Journal Article] Association between hepatocyte growth factor gene polymorphism and essential hypertension.2004
- Author(s)
  Motone M, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 247-251
- NAID
  10012925825
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension2004
- Author(s)
  Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T
- Journal Title
  
  Hypertension 43
  
  Pages: 1318-1323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension.2004
- Author(s)
  Iwashima Y, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertension 43
  
  Pages: 1318-1323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Hypertension in a patient with Gitelman's syndrome.2004
- Author(s)
  Ogihara T
- Journal Title
  
  Journal of Human Hypertension 18
  
  Pages: 677-679
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590342
[Journal Article] Adiponectin 1164T mutation is associated with the metabolic syndrome and coronary artery disease.2004
- Author(s)
  Ohashi K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Am Coll Cardiol. 43
  
  Pages: 1195-2000
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension : the Ohasama Study.2004
- Author(s)
  Sugimoto K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 551-556
- NAID
  10013604128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.2004
- Author(s)
  Matsuo A, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 22
  
  Pages: 2123-2127
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Journal Article] Adiponectin 1164T mutation is associated with the metabolic syndrome and coronary artery disease.2004
- Author(s)
  Ohashi K, Ouchi N, Kihara S, Funahashi T, Nakamura T, Sumitsuji S, Kawamoto T, Matsumoto S, Nagaretani H, Kumada M, Okamoto Y, Nishizawa H, Kishida K, Maeda N, Hiraoka H, Iwashima Y, Ishikawa K, Ohishi M, Katsuya T, Rakugi H, Ogihara T, Matsuzawa Y.
- Journal Title
  
  J Am Coll Cardiol 43
  
  Pages: 1198-1200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Association between hepatocyte growth factor gene polymorphism and essential hypertension.2004
- Author(s)
  Motone M, Katsuya T, Ohishi M, Ogihara T et al.
- Journal Title
  
  Hypertens Res 27
  
  Pages: 247-252
- NAID
  10012925825
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590684
[Journal Article] Association of methylenetetrabydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population2003
- Author(s)
  Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, Ogata J, Tomoike H, Ogihara T
- Journal Title
  
  Stroke 34
  
  Pages: 1628-1633
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population.2003
- Author(s)
  Inamoto N, Katsuya T, Ogihara T, et al.
- Journal Title
  
  Stroke 34
  
  Pages: 1628-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Candesartan antihypertensive survival evaluation in Japan(CASE-J). Trial of cardiovascular events in high-risk hypertensive patients : Rationale, design, and methods.2003
- Author(s)
  Fukui T, Rahman M, Hayashi K, Takeda K, Higaki J, Sato T, Fukushima M, Sakamoto J, Morita S, Ogihara T, Fukiyama K, Fujishima M, Saruta T.
- Journal Title
  
  Hypertension Research 26
  
  Pages: 979-990
- NAID
  10011999082
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370226
[Journal Article] 「研究成果報告書概要(欧文)」より2003
- Author(s)
  Fukui T, Rahman M, Hayashi K, Takeda K, Higaki J, Sato T, Fukushima M, Sakamoto J, Morita S, Ogihara T, Fukiyama K, Fujishima M, Saruta T.
- Journal Title
  
  Hypertension Research 26
  
  Pages: 979-990
- Data Source
  KAKENHI-PROJECT-14370226
[Journal Article] Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects : the Suita Study2002
- Author(s)
  Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, Asai T, Fukuda M, Higaki J, Ogata J, Ogihara T
- Journal Title
  
  J Hypertens 20
  
  Pages: 2017-2021
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects : the Suita Study.2002
- Author(s)
  Katsuya T, Ogihara T, et al.
- Journal Title
  
  JHypertens 20
  
  Pages: 2017-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study2002
- Author(s)
  Sugimoto K, Hozawa A, Katsuya T, Matsubara M, Ohkubo T, Tsuji I, Motone M, Higaki J, Hisamachi S, Imai Y, Ogihara T
- Journal Title
  
  J Hypertens 20
  
  Pages: 1779-1784
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Journal Article] Alpha-Adducin Gly460Trp polymorphism is associated with low rennin hypertension in younger subjects in the Ohasama study.2002
- Author(s)
  Sugimoto K, Katsuya T, Ogihara T, et al.
- Journal Title
  
  J Hypertens 20
  
  Pages: 1779-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Patent] アシジオテンシン変換酵素遺伝子の挿入/欠失多型の効率的タイピング方法2004
- Inventor(s)
  勝谷友宏, 杉本研, 赤坂憲, 荻原俊男
- Industrial Property Rights Holder
  勝谷友宏, 杉本研, 赤坂憲, 荻原俊男
- Industrial Property Number
  2004-119417
- Filing Date
  2004-04-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Patent] アンジオテンシン変換酵素遺伝子の挿入/欠失多型の効率的タイピング方法2004
- Inventor(s)
  勝谷友宏, 杉本研, 赤坂憲, 荻原俊男
- Industrial Property Rights Holder
  勝谷友宏, 荻原俊男, イビーエス(株)
- Industrial Property Number
  2004-119417
- Filing Date
  2004-04-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207035
[Patent] エンドセリン1遺伝子中の多型を利用した高血圧症の遺伝子診断およびこれに用いるための核酸分子2002
- Inventor(s)
  荻原俊男, 河野雄平, 万波俊文, 宮田敏行, 友池仁暢
- Industrial Property Rights Holder
  荻原俊男, 河野雄平, 万波俊文, 宮田敏行, 友池仁暢
- Industrial Property Number
  2002-263015
- Filing Date
  2002-09-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204050
[Presentation] Effect of angiotensin II on differentiation and apoptosis of chondrocytes in cartilage formation in the process of fracture healing2015
- Author(s)
  26.Hirohisa Kawahata, Motokuni Aoki, Ryuichi Morishita, Toshio Ogihara
- Organizer
  11th Asia Pacific Congress of Hypertension
- Place of Presentation
  Bali, Indonesia
- Year and Date
  2015-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460928
[Presentation] レニン―アンジオテンシン系が骨折修復過程に与える影響についての検討2013
- Author(s)
  青木元邦,川畑浩久,森下竜,荻原俊男
- Organizer
  第55回日本老年医学会
- Place of Presentation
  大阪国際会議場．大阪
- Data Source
  KAKENHI-PROJECT-23590902
[Presentation] レニンーアンジオテンシン系が骨折修復過程に与える影響についての検討2013
- Author(s)
  青木元邦、川畑浩久、荻原俊男
- Organizer
  第55回日本老年医学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23590902
[Presentation] 高齢者高血圧患者におけるアンジオテンシン受容体拮抗薬による骨密度減少の抑制効果2012
- Author(s)
  青木元邦、湯久浩、守口篤、志水秀朗、中神啓徳、荻原俊男、森下竜一
- Organizer
  日本高血圧学会第一回臨床高血圧フォーラム
- Place of Presentation
  大阪
- Year and Date
  2012-05-12
- Data Source
  KAKENHI-PROJECT-23590902

1. HIGAKI Jitsuo (70189744)

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2. RAKUGI Hiromi (20252679)

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24. KOJIMA Yoshihisa (40454681)

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25. NAKAHARA Hidehiro (90514000)

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26. UEDA Shinya (40616926)

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27. NABETA Tomoyuki (00597817)

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28. MATSUKUMA Hideaki (70518638)

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29. YOSHIKAWA Yuki (20614085)

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30. NABETA Rie (60249464)

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31. YASUDA Minoru (80454693)

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32. SERIKAWA Tadao (30025655)

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33. KOMEDA Kajyuro (90074533)

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34. UEDA Makiko (10137193)

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35. OKURA Takafumi (40260385)

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36. 家森幸男 (80025600)

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37. 三須良実 (10025687)

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38. 西尾一郎 (40089165)

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39. 猿田享男 (70051571)

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40. 黒川清 (30167390)

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41. 長野正広 (50228045)

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42. 池上博司 (20221062)

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43. 東森浩一 (70238278)

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44. DZAU Victor J

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45. HASEGAWA Mamoru

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46. 野間喜彦

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47. 紙野晃人

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48. 名倉潤

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49. 坂口勝彦

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50. 山本浩一

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51. 橋爪喜代子

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52. 原宏子

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53. 田渕義勝

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54. 樂木宏美

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# of Collaborated Products: 5 results

OGIHARA Toshio 荻原 俊男

萩原 俊男 ハギワラ トシオ

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A comprehensive study on teacher training in medical and health science universities:Principal Investigator

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Naチャンネル制御遺伝子導入システムによる高血圧症に対する革新的分子治療法の開発Principal Investigator

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Identification of the susceptible gene responsible for essential hypertension and establishment of tailored medicinePrincipal Investigator

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Identification of genetic factors responsible for the pathogenesis of essential hypertensionPrincipal Investigator

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本態性高血圧症の発症、進展に関与する遺伝因子の解明Principal Investigator

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多因子遺伝子性循環器疾患の遺伝子解析へのDNAチップ技術の応用Principal Investigator

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OGIHARA Toshio 荻原俊男

萩原俊男ハギワラトシオ