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HARA Akiyoshi  原 明義

ORCIDConnect your ORCID iD *help
Researcher Number 90164988
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2006 – 2008: 国際医療福祉大学, 薬学部, 教授
1999 – 2005: 旭川医科大学, 医学部, 助教授
1994 – 1996: 旭川医科大学, 医学部, 助手
1994: Asahikawa Medical College, School of Medicine, Assistant, 医学部・薬理学講座, 助手
Review Section/Research Field
Principal Investigator
General pharmacology / Pathological medical chemistry / General pharmacology
Except Principal Investigator
General pharmacology / Pathological medical chemistry
Keywords
Principal Investigator
ラット / 心臓 / アデノシン / エネルギー代謝 / 心機能 / プロスタグランジンI_2 / マウス / 心肥大 / 心筋リモデリング / プロスタノイド … More / ジラゼップ / mice / cardiac remodeling / cardiac fibrosis / cardiac hypertrophy / prostanoid receptors / prostaglandin I_2 / prostanoids / プロスタグランジン I_2 / 線維化 / 受容体 / 心筋細胞 / アスピリン / 寒冷ストレス / 非ステロイド性抗炎症薬 / K-7259 / 長鎖アシルカルニチン / 脂質過酸化 / フリーラジカル / Hydrogen peroxide / ATP感受性Kチャネル / 低酸素 … More
Except Principal Investigator
prostaglandin / 虚血・再潅流 / トロンボキサン / プロスタグランジン / プロスタノイド / platelets / prostanoid receptor / knockout mice / thromboxane / prostanoids / 血小板 / プロスタノイド受容体 / ノックアウトマウス / 心筋 / 虚血・再潅流障害 / dilazep / 活性酸素 / prostanoid / 血管 / 心臓 / ischemia-reperfusipn / allergic asthma / fertilization / 大腸癌 / 気管支喘息 / 肺高血圧症 / 中枢神経機能 / アレルギー性喘息 / 受精 / ischemia-reperfusion / cardiovascular system / 心肥大 / 心筋虚血 / 循環器 / 循環器系 / Nitric oxide / Palmitoylcarnitin / Lysophosphatidylcholine / oxygen radicals / reperfusion damage / ischemia / Myocardium / L-NAME / 摘出心臓 / ラット / NO / K-7259 / 心筋保護 / 虚血-再潅流障害 / 一酸化窒素 / パルミトイル-L-カルニチン / リゾホスファチジルコリン / DILAZEP / d-PROPRANOLOL / LYSOPHOPHATIDYLCHOLINE / INTRACELLULAR CALCIUM / HYDROGEN PEROXIDE / OXYGEN RADICAL / リドカイン / propranolol / Na^+チャネル / veratridine / [Ca^<2+>]_<in> / ラット心室筋細胞 / d-propranolol / lysophosphatidylcholine / 細胞内Ca^<2+>濃度 / 過酸化水素 Less
  • Research Projects

    (10 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (11 People)
  •  A study of the roles of prostanoids and its therapeutic application in cardiovascular remodelingPrincipal Investigator

    • Principal Investigator
      HARA Akiyoshi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      International University of Health and Welfare
  •  A study of roles of the prostanoids in cardiovascular remodeling using mice lacking deficient in prostanoid receptorsPrincipal Investigator

    • Principal Investigator
      HARA Akiyoshi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Asahikawa Medical College
  •  Roles of prostanoids in cardiovascular system revealed from studies using knockout mice

    • Principal Investigator
      USHIKUBI Fumitaka
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Asahikawa Medical College
  •  Roles of prostanoids in cardiovascularsystem revealed from studies using knockout mice

    • Principal Investigator
      USHIKUBI Fumitaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College
  •  Physiological and Pathophysiological roles of prostanoids revealed from studies using mice lacking their receptors

    • Principal Investigator
      USHIKUBI Fumitaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College
  •  長鎖アシルカルニチンによる心筋障害とその防御に関する薬理学的研究Principal Investigator

    • Principal Investigator
      原 明義
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College
  •  フリーラジカルによる心筋障害を防御する薬物とその作用機構に関する研究Principal Investigator

    • Principal Investigator
      原 明義
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College
  •  The role of nitric oxide in ischemia/reperfusion damage in the heart

    • Principal Investigator
      ABIKO Yasushi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College
  •  フリーラジカルによる心筋障害に対する生体内防御機構の解明Principal Investigator

    • Principal Investigator
      原 明義
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College
  •  Pharmacological study on the derangements of myocardial cells induced by oxygen radicals, and protection from the derangements

    • Principal Investigator
      ABIKO Yasushi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Asahikawa Medical College

All 2009 2007 2005

All Journal Article Presentation

  • [Journal Article] Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I_2 receptor2005

    • Author(s)
      Akiyoshi Hara
    • Journal Title

      Circulation 112・1

      Pages: 84-92

    • Data Source
      KAKENHI-PROJECT-15590265
  • [Journal Article] Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor2005

    • Author(s)
      Akiyoshi Hara
    • Journal Title

      Circulation 112・1

      Pages: 84-92

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590265
  • [Presentation] 寒冷ストレスによる心肥大形成に対するアスピリンの作用2009

    • Author(s)
      原 明義, 花開孝宏, 近藤祐樹, 柳沢照史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-18590229
  • [Presentation] 寒冷ストレスによる心肥大形成に対するアスピリンの作用2009

    • Author(s)
      原 明義、花開 孝宏、近藤 祐樹、柳沢 照史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-18590229
  • [Presentation] プロスタグランジンE_2はその受容体EP_3を介して虚血-再灌流障害から心臓を保護する2007

    • Author(s)
      結城幸一、肖 春陽、原 明義、川辺純一、成宮 周、牛首文隆
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2007-03-16
    • Data Source
      KAKENHI-PROJECT-18590229
  • 1.  YUHKI Koh-ichi (80302420)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 2.  USHIKUBI Fumitaka (50243035)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 3.  ABIKO Yasushi (90041821)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  HASHIZUME Hiroko (00154021)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  藤野 貴行 (70322914)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  YAZAWA Kazuto (90212274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOBAYASHI Takuya (20311730)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  BITO Haruhiko (00291964)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  HANAKAI Takahiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  KONDO Yuhki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  YANAGISAWA Terufumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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